-- dump date 20140618_185105 -- class Genbank::misc_feature -- table misc_feature_note -- id note 380394000001 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 380394000002 DnaA N-terminal domain; Region: DnaA_N; pfam11638 380394000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 380394000004 Walker A motif; other site 380394000005 ATP binding site [chemical binding]; other site 380394000006 Walker B motif; other site 380394000007 arginine finger; other site 380394000008 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 380394000009 DnaA box-binding interface [nucleotide binding]; other site 380394000010 DNA polymerase III subunit beta; Validated; Region: PRK05643 380394000011 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 380394000012 putative DNA binding surface [nucleotide binding]; other site 380394000013 dimer interface [polypeptide binding]; other site 380394000014 beta-clamp/clamp loader binding surface; other site 380394000015 beta-clamp/translesion DNA polymerase binding surface; other site 380394000016 recombination protein F; Reviewed; Region: recF; PRK00064 380394000017 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 380394000018 Walker A/P-loop; other site 380394000019 ATP binding site [chemical binding]; other site 380394000020 Q-loop/lid; other site 380394000021 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 380394000022 ABC transporter signature motif; other site 380394000023 Walker B; other site 380394000024 D-loop; other site 380394000025 H-loop/switch region; other site 380394000026 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 380394000027 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 380394000028 ATP binding site [chemical binding]; other site 380394000029 Mg2+ binding site [ion binding]; other site 380394000030 G-X-G motif; other site 380394000031 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 380394000032 anchoring element; other site 380394000033 dimer interface [polypeptide binding]; other site 380394000034 ATP binding site [chemical binding]; other site 380394000035 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 380394000036 active site 380394000037 putative metal-binding site [ion binding]; other site 380394000038 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 380394000039 putative bifunctional glutamate synthase subunit beta/2-polyprenylphenol hydroxylase; Validated; Region: PRK06567 380394000040 FAD/NAD binding domain (electron transfer subunit) of dihydroorotate dehydrogenase-like proteins. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate...; Region: DHOD_e_trans_like; cd06192 380394000041 FAD binding pocket [chemical binding]; other site 380394000042 FAD binding motif [chemical binding]; other site 380394000043 phosphate binding motif [ion binding]; other site 380394000044 beta-alpha-beta structure motif; other site 380394000045 NAD binding pocket [chemical binding]; other site 380394000046 Iron coordination center [ion binding]; other site 380394000047 Uncharacterized secreted protein [Function unknown]; Region: COG5430 380394000048 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 380394000049 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 380394000050 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 380394000051 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 380394000052 PapC C-terminal domain; Region: PapC_C; pfam13953 380394000053 Spore Coat Protein U domain; Region: SCPU; pfam05229 380394000054 Septum formation topological specificity factor MinE; Region: MinE; cl00538 380394000055 Protein of unknown function (DUF2442); Region: DUF2442; pfam10387 380394000056 cell division topological specificity factor MinE; Reviewed; Region: minE; PRK00296 380394000057 Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894 380394000058 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 380394000059 Switch I; other site 380394000060 Switch II; other site 380394000061 Septum formation inhibitor MinC, N-terminal domain; Region: MinC_N; pfam05209 380394000062 septum site-determining protein MinC; Region: minC; TIGR01222 380394000063 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 380394000064 Ferredoxin [Energy production and conversion]; Region: COG1146 380394000065 Domain of unknown function (DUF3470); Region: DUF3470; pfam11953 380394000066 DNA topoisomerase I; Validated; Region: PRK06599 380394000067 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 380394000068 active site 380394000069 interdomain interaction site; other site 380394000070 putative metal-binding site [ion binding]; other site 380394000071 nucleotide binding site [chemical binding]; other site 380394000072 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 380394000073 domain I; other site 380394000074 DNA binding groove [nucleotide binding] 380394000075 phosphate binding site [ion binding]; other site 380394000076 domain II; other site 380394000077 domain III; other site 380394000078 nucleotide binding site [chemical binding]; other site 380394000079 catalytic site [active] 380394000080 domain IV; other site 380394000081 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 380394000082 Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551 380394000083 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 380394000084 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 380394000085 Protein of unknown function (DUF494); Region: DUF494; cl01103 380394000086 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758 380394000087 DNA protecting protein DprA; Region: dprA; TIGR00732 380394000088 Uncharacterized protein containing LysM domain [Function unknown]; Region: XkdP; COG1652 380394000089 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 380394000090 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 380394000091 active site 380394000092 catalytic residues [active] 380394000093 metal binding site [ion binding]; metal-binding site 380394000094 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 380394000095 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 380394000096 putative active site [active] 380394000097 substrate binding site [chemical binding]; other site 380394000098 putative cosubstrate binding site; other site 380394000099 catalytic site [active] 380394000100 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 380394000101 substrate binding site [chemical binding]; other site 380394000102 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223 380394000103 putative RNA binding site [nucleotide binding]; other site 380394000104 16S rRNA methyltransferase B; Provisional; Region: PRK10901 380394000105 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 380394000106 S-adenosylmethionine binding site [chemical binding]; other site 380394000107 Domain of unknown function (DUF4390); Region: DUF4390; pfam14334 380394000108 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 380394000109 dimerization interface [polypeptide binding]; other site 380394000110 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 380394000111 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 380394000112 dimer interface [polypeptide binding]; other site 380394000113 phosphorylation site [posttranslational modification] 380394000114 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 380394000115 ATP binding site [chemical binding]; other site 380394000116 G-X-G motif; other site 380394000117 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 380394000118 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 380394000119 active site 380394000120 phosphorylation site [posttranslational modification] 380394000121 intermolecular recognition site; other site 380394000122 dimerization interface [polypeptide binding]; other site 380394000123 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 380394000124 Walker A motif; other site 380394000125 ATP binding site [chemical binding]; other site 380394000126 Walker B motif; other site 380394000127 arginine finger; other site 380394000128 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 380394000129 HAMP domain; Region: HAMP; pfam00672 380394000130 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 380394000131 dimer interface [polypeptide binding]; other site 380394000132 phosphorylation site [posttranslational modification] 380394000133 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 380394000134 ATP binding site [chemical binding]; other site 380394000135 Mg2+ binding site [ion binding]; other site 380394000136 G-X-G motif; other site 380394000137 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 380394000138 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 380394000139 active site 380394000140 phosphorylation site [posttranslational modification] 380394000141 intermolecular recognition site; other site 380394000142 dimerization interface [polypeptide binding]; other site 380394000143 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 380394000144 Walker A motif; other site 380394000145 ATP binding site [chemical binding]; other site 380394000146 Walker B motif; other site 380394000147 arginine finger; other site 380394000148 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 380394000149 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 380394000150 active site 380394000151 Trp docking motif [polypeptide binding]; other site 380394000152 PQQ-like domain; Region: PQQ_2; pfam13360 380394000153 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 380394000154 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 380394000155 trmE is a tRNA modification GTPase; Region: trmE; cd04164 380394000156 G1 box; other site 380394000157 GTP/Mg2+ binding site [chemical binding]; other site 380394000158 Switch I region; other site 380394000159 G2 box; other site 380394000160 Switch II region; other site 380394000161 G3 box; other site 380394000162 G4 box; other site 380394000163 G5 box; other site 380394000164 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 380394000165 membrane protein insertase; Provisional; Region: PRK01318 380394000166 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 380394000167 Haemolytic domain; Region: Haemolytic; pfam01809 380394000168 Ribonuclease P; Region: Ribonuclease_P; pfam00825 380394000169 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 380394000170 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 380394000171 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 380394000172 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 380394000173 ABC transporter; Region: ABC_tran_2; pfam12848 380394000174 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 380394000175 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 380394000176 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 380394000177 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 380394000178 dimerization interface [polypeptide binding]; other site 380394000179 substrate binding pocket [chemical binding]; other site 380394000180 efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998 380394000181 HlyD family secretion protein; Region: HlyD_3; pfam13437 380394000182 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 380394000183 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 380394000184 Major Facilitator Superfamily; Region: MFS_1; pfam07690 380394000185 Tellurite-resistance/Dicarboxylate Transporter (TDT) family includes sulfite sensitivity protein (sulfite efflux pump; SSU1); Region: TDT_SSU1; cd09318 380394000186 Tellurite resistance protein and related permeases [Inorganic ion transport and metabolism]; Region: TehA; COG1275 380394000187 gating phenylalanine in ion channel; other site 380394000188 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 380394000189 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 380394000190 TQO small subunit DoxD; Region: DoxD; pfam04173 380394000191 TQO small subunit DoxA; Region: DoxA; pfam07680 380394000192 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 380394000193 active site residue [active] 380394000194 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 380394000195 active site residue [active] 380394000196 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 380394000197 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 380394000198 catalytic residues [active] 380394000199 TQO small subunit DoxD; Region: DoxD; pfam04173 380394000200 TQO small subunit DoxA; Region: DoxA; pfam07680 380394000201 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 380394000202 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 380394000203 Sulphur transport; Region: Sulf_transp; pfam04143 380394000204 MarC family integral membrane protein; Region: MarC; cl00919 380394000205 putative regulatory protein, FmdB family; Region: CxxC_CxxC_SSSS; TIGR02605 380394000206 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 380394000207 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 380394000208 dimer interface [polypeptide binding]; other site 380394000209 anticodon binding site; other site 380394000210 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 380394000211 homodimer interface [polypeptide binding]; other site 380394000212 motif 1; other site 380394000213 active site 380394000214 motif 2; other site 380394000215 GAD domain; Region: GAD; pfam02938 380394000216 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 380394000217 motif 3; other site 380394000218 quinolinate synthetase; Provisional; Region: PRK09375 380394000219 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 380394000220 putative acyl-acceptor binding pocket; other site 380394000221 hypothetical protein; Validated; Region: PRK00110 380394000222 Holliday junction resolvase; Reviewed; Region: ruvC; PRK00039 380394000223 active site 380394000224 putative DNA-binding cleft [nucleotide binding]; other site 380394000225 dimer interface [polypeptide binding]; other site 380394000226 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 380394000227 RuvA N terminal domain; Region: RuvA_N; pfam01330 380394000228 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 380394000229 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 380394000230 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 380394000231 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 380394000232 Walker A motif; other site 380394000233 ATP binding site [chemical binding]; other site 380394000234 Walker B motif; other site 380394000235 arginine finger; other site 380394000236 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 380394000237 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 380394000238 active site 380394000239 TolQ protein; Region: tolQ; TIGR02796 380394000240 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 380394000241 TolR protein; Region: tolR; TIGR02801 380394000242 TolA protein; Region: tolA_full; TIGR02794 380394000243 TolA protein; Region: tolA_full; TIGR02794 380394000244 Gram-negative bacterial tonB protein; Region: TonB; cl10048 380394000245 tol-pal system beta propeller repeat protein TolB; Region: propeller_TolB; TIGR02800 380394000246 TolB amino-terminal domain; Region: TolB_N; pfam04052 380394000247 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 380394000248 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 380394000249 Ligand Binding Site [chemical binding]; other site 380394000250 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE, gammaproteobacterial type; Region: rSAM_QueE_gams; TIGR04349 380394000251 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 380394000252 FeS/SAM binding site; other site 380394000253 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 380394000254 Tetratricopeptide repeat; Region: TPR_6; pfam13174 380394000255 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 380394000256 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 380394000257 ligand binding site [chemical binding]; other site 380394000258 Undecaprenyl-phosphate galactose phosphotransferase, WbaP; Region: WbaP_sugtrans; TIGR03022 380394000259 Bacterial sugar transferase; Region: Bac_transf; pfam02397 380394000260 Chain length determinant protein; Region: Wzz; pfam02706 380394000261 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 380394000262 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 380394000263 putative DNA binding site [nucleotide binding]; other site 380394000264 putative Zn2+ binding site [ion binding]; other site 380394000265 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 380394000266 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 380394000267 Methyltransferase domain; Region: Methyltransf_23; pfam13489 380394000268 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 380394000269 S-adenosylmethionine binding site [chemical binding]; other site 380394000270 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 380394000271 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 380394000272 active site 380394000273 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 380394000274 This family is most closely related to the GT1 family of glycosyltransferases. ExpE7 in Sinorhizobium meliloti has been shown to be involved in the biosynthesis of galactoglucans (exopolysaccharide II); Region: GT1_ExpE7_like; cd03823 380394000275 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 380394000276 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 380394000277 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 380394000278 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 380394000279 active site 380394000280 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 380394000281 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 380394000282 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 380394000283 PIN domain of the hypothetical protein MT3492 of Mycobacterium tuberculosis CDC1551 and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MT3492; cd09874 380394000284 putative active site [active] 380394000285 Plasmid maintenance system killer protein; Region: Plasmid_killer; cl01422 380394000286 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 380394000287 non-specific DNA binding site [nucleotide binding]; other site 380394000288 salt bridge; other site 380394000289 sequence-specific DNA binding site [nucleotide binding]; other site 380394000290 Fic family protein [Function unknown]; Region: COG3177 380394000291 Fic/DOC family N-terminal; Region: Fic_N; pfam13784 380394000292 Fic/DOC family; Region: Fic; pfam02661 380394000293 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 380394000294 putative DNA binding site [nucleotide binding]; other site 380394000295 putative Zn2+ binding site [ion binding]; other site 380394000296 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 380394000297 Proto-chlorophyllide reductase 57 kD subunit; Region: PCP_red; pfam08369 380394000298 Predicted membrane protein [Function unknown]; Region: COG2259 380394000299 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 380394000300 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 380394000301 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 380394000302 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 380394000303 catalytic triad [active] 380394000304 conserved cis-peptide bond; other site 380394000305 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 380394000306 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 380394000307 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 380394000308 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 380394000309 Walker A/P-loop; other site 380394000310 ATP binding site [chemical binding]; other site 380394000311 Q-loop/lid; other site 380394000312 ABC transporter signature motif; other site 380394000313 Walker B; other site 380394000314 D-loop; other site 380394000315 H-loop/switch region; other site 380394000316 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 380394000317 DevC protein; Region: devC; TIGR01185 380394000318 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 380394000319 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 380394000320 osmolarity sensor protein; Provisional; Region: envZ; PRK09467 380394000321 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 380394000322 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 380394000323 ATP binding site [chemical binding]; other site 380394000324 Mg2+ binding site [ion binding]; other site 380394000325 G-X-G motif; other site 380394000326 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 380394000327 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 380394000328 active site 380394000329 phosphorylation site [posttranslational modification] 380394000330 intermolecular recognition site; other site 380394000331 dimerization interface [polypeptide binding]; other site 380394000332 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 380394000333 DNA binding site [nucleotide binding] 380394000334 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 380394000335 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 380394000336 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 380394000337 HlyD family secretion protein; Region: HlyD_3; pfam13437 380394000338 multidrug efflux protein; Reviewed; Region: PRK09579 380394000339 Bacterial protein of unknown function (DUF924); Region: DUF924; pfam06041 380394000340 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 380394000341 Type III secretion system lipoprotein chaperone (YscW); Region: YscW; cl15825 380394000342 lipoprotein involved with copper homeostasis and adhesion; Provisional; Region: PRK10523 380394000343 META domain; Region: META; pfam03724 380394000344 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 380394000345 Sel1-like repeats; Region: SEL1; smart00671 380394000346 Sel1-like repeats; Region: SEL1; smart00671 380394000347 Sel1-like repeats; Region: SEL1; smart00671 380394000348 Sel1-like repeats; Region: SEL1; smart00671 380394000349 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880 380394000350 Domain of unknown function (DUF4338); Region: DUF4338; pfam14236 380394000351 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 380394000352 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 380394000353 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 380394000354 ligand binding site [chemical binding]; other site 380394000355 flexible hinge region; other site 380394000356 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 380394000357 non-specific DNA interactions [nucleotide binding]; other site 380394000358 DNA binding site [nucleotide binding] 380394000359 sequence specific DNA binding site [nucleotide binding]; other site 380394000360 putative cAMP binding site [chemical binding]; other site 380394000361 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 380394000362 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 380394000363 UGMP family protein; Validated; Region: PRK09604 380394000364 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 380394000365 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 380394000366 binding surface 380394000367 TPR motif; other site 380394000368 Glycerol-3-phosphate acyltransferase; Region: G3P_acyltransf; cl00410 380394000369 Dihydroneopterin aldolase; Region: FolB; smart00905 380394000370 active site 380394000371 ribosomal protein S12 methylthiotransferase; Provisional; Region: rimO; PRK14862 380394000372 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 380394000373 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 380394000374 FeS/SAM binding site; other site 380394000375 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 380394000376 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 380394000377 catalytic residues [active] 380394000378 catalytic nucleophile [active] 380394000379 Recombinase; Region: Recombinase; pfam07508 380394000380 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 380394000381 transcriptional repressor DicA; Reviewed; Region: PRK09706 380394000382 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 380394000383 non-specific DNA binding site [nucleotide binding]; other site 380394000384 salt bridge; other site 380394000385 sequence-specific DNA binding site [nucleotide binding]; other site 380394000386 Protein of unknown function (DUF1376); Region: DUF1376; cl01531 380394000387 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 380394000388 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 380394000389 Walker A motif; other site 380394000390 ATP binding site [chemical binding]; other site 380394000391 Walker B motif; other site 380394000392 arginine finger; other site 380394000393 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dam; COG0338 380394000394 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 380394000395 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 380394000396 dimer interface [polypeptide binding]; other site 380394000397 ssDNA binding site [nucleotide binding]; other site 380394000398 tetramer (dimer of dimers) interface [polypeptide binding]; other site 380394000399 AAA domain; Region: AAA_22; pfam13401 380394000400 DDE superfamily endonuclease; Region: DDE_3; pfam13358 380394000401 Winged helix-turn helix; Region: HTH_29; pfam13551 380394000402 Winged helix-turn helix; Region: HTH_33; pfam13592 380394000403 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 380394000404 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 380394000405 Domain of unknown function (DUF4338); Region: DUF4338; pfam14236 380394000406 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 380394000407 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880 380394000408 A-factor biosynthesis hotdog domain; Region: AfsA; pfam03756 380394000409 Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231 380394000410 hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466 380394000411 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 380394000412 NAD(P) binding site [chemical binding]; other site 380394000413 active site 380394000414 Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966 380394000415 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 380394000416 MgtC family; Region: MgtC; pfam02308 380394000417 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 380394000418 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 380394000419 Helix-Turn-Helix DNA binding domain of the MerR1 transcription regulator; Region: HTH_MerR1; cd04783 380394000420 Hg(II)-responsive transcriptional regulator; Region: MerR; TIGR02051 380394000421 DNA binding residues [nucleotide binding] 380394000422 dimer interface [polypeptide binding]; other site 380394000423 mercury binding site [ion binding]; other site 380394000424 putative mercury transport protein MerC; Provisional; Region: PRK13755 380394000425 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 380394000426 metal-binding site [ion binding] 380394000427 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 380394000428 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 380394000429 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 380394000430 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 380394000431 metal-binding site [ion binding] 380394000432 putative mercury transport protein MerC; Provisional; Region: PRK13755 380394000433 Helix-Turn-Helix DNA binding domain of the MerR1 transcription regulator; Region: HTH_MerR1; cd04783 380394000434 Hg(II)-responsive transcriptional regulator; Region: MerR; TIGR02051 380394000435 DNA binding residues [nucleotide binding] 380394000436 dimer interface [polypeptide binding]; other site 380394000437 mercury binding site [ion binding]; other site 380394000438 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 380394000439 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD2; cd08298 380394000440 putative substrate binding site [chemical binding]; other site 380394000441 catalytic Zn binding site [ion binding]; other site 380394000442 structural Zn binding site [ion binding]; other site 380394000443 putative NAD(P) binding site [chemical binding]; other site 380394000444 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 380394000445 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 380394000446 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 380394000447 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 380394000448 motif II; other site 380394000449 Outer membrane efflux protein; Region: OEP; pfam02321 380394000450 Outer membrane efflux protein; Region: OEP; pfam02321 380394000451 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 380394000452 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 380394000453 HlyD family secretion protein; Region: HlyD_3; pfam13437 380394000454 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 380394000455 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 380394000456 Copper binding periplasmic protein CusF; Region: CusF_Ec; pfam11604 380394000457 Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; cl01768 380394000458 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 380394000459 Helix-turn-helix domain; Region: HTH_28; pfam13518 380394000460 putative transposase OrfB; Reviewed; Region: PHA02517 380394000461 HTH-like domain; Region: HTH_21; pfam13276 380394000462 Integrase core domain; Region: rve; pfam00665 380394000463 Integrase core domain; Region: rve_2; pfam13333 380394000464 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 380394000465 non-specific DNA binding site [nucleotide binding]; other site 380394000466 salt bridge; other site 380394000467 sequence-specific DNA binding site [nucleotide binding]; other site 380394000468 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 380394000469 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 380394000470 Outer membrane efflux protein; Region: OEP; pfam02321 380394000471 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 380394000472 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 380394000473 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 380394000474 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 380394000475 motif II; other site 380394000476 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 380394000477 dimerization interface [polypeptide binding]; other site 380394000478 putative DNA binding site [nucleotide binding]; other site 380394000479 putative Zn2+ binding site [ion binding]; other site 380394000480 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 380394000481 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 380394000482 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 380394000483 catalytic residue [active] 380394000484 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 380394000485 S-adenosylmethionine binding site [chemical binding]; other site 380394000486 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 380394000487 glutaredoxin 2; Provisional; Region: PRK10387 380394000488 C-terminal domain interface [polypeptide binding]; other site 380394000489 GSH binding site (G-site) [chemical binding]; other site 380394000490 dimer interface [polypeptide binding]; other site 380394000491 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 380394000492 dimerization interface [polypeptide binding]; other site 380394000493 putative DNA binding site [nucleotide binding]; other site 380394000494 putative Zn2+ binding site [ion binding]; other site 380394000495 Short C-terminal domain; Region: SHOCT; pfam09851 380394000496 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 380394000497 S-adenosylmethionine binding site [chemical binding]; other site 380394000498 MarR family; Region: MarR_2; cl17246 380394000499 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 380394000500 Insertion element 4 transposase N-terminal; Region: Nterm_IS4; pfam13006 380394000501 Copper binding periplasmic protein CusF; Region: CusF_Ec; pfam11604 380394000502 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 380394000503 binding surface 380394000504 Tetratricopeptide repeat; Region: TPR_16; pfam13432 380394000505 TPR motif; other site 380394000506 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 380394000507 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 380394000508 TPR motif; other site 380394000509 binding surface 380394000510 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 380394000511 binding surface 380394000512 TPR motif; other site 380394000513 Tetratricopeptide repeat; Region: TPR_10; pfam13374 380394000514 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 380394000515 binding surface 380394000516 TPR motif; other site 380394000517 TPR repeat; Region: TPR_11; pfam13414 380394000518 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880 380394000519 Domain of unknown function (DUF4338); Region: DUF4338; pfam14236 380394000520 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 380394000521 Outer membrane protein family (DUF1597); Region: DUF1597; pfam07642 380394000522 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 380394000523 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 380394000524 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 380394000525 Walker A/P-loop; other site 380394000526 ATP binding site [chemical binding]; other site 380394000527 Q-loop/lid; other site 380394000528 ABC transporter signature motif; other site 380394000529 Walker B; other site 380394000530 D-loop; other site 380394000531 H-loop/switch region; other site 380394000532 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 380394000533 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 380394000534 catalytic residues [active] 380394000535 Disulphide bond corrector protein DsbC; Region: DsbC; pfam11412 380394000536 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 380394000537 dimerization interface [polypeptide binding]; other site 380394000538 putative DNA binding site [nucleotide binding]; other site 380394000539 putative Zn2+ binding site [ion binding]; other site 380394000540 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 380394000541 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 380394000542 Soluble P-type ATPase [General function prediction only]; Region: COG4087 380394000543 Domain of unknown function DUF302; Region: DUF302; pfam03625 380394000544 Predicted membrane protein [Function unknown]; Region: COG3462 380394000545 Short C-terminal domain; Region: SHOCT; pfam09851 380394000546 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 380394000547 dimer interface [polypeptide binding]; other site 380394000548 [2Fe-2S] cluster binding site [ion binding]; other site 380394000549 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 380394000550 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 380394000551 Integrase core domain; Region: rve; pfam00665 380394000552 transposase; Provisional; Region: PRK06526 380394000553 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 380394000554 Walker A motif; other site 380394000555 ATP binding site [chemical binding]; other site 380394000556 Short C-terminal domain; Region: SHOCT; pfam09851 380394000557 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 380394000558 Integrase core domain; Region: rve; pfam00665 380394000559 TnsA endonuclease N terminal; Region: Tn7_Tnp_TnsA_N; pfam08722 380394000560 Protein of unknown function DUF91; Region: DUF91; cl00709 380394000561 DEAD-like helicases superfamily; Region: DEXDc; smart00487 380394000562 Type III restriction enzyme, res subunit; Region: ResIII; pfam04851 380394000563 Type III restriction enzyme, res subunit; Region: ResIII; pfam04851 380394000564 EcoEI R protein C-terminal; Region: EcoEI_R_C; pfam08463 380394000565 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 380394000566 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 380394000567 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 380394000568 HsdM N-terminal domain; Region: HsdM_N; pfam12161 380394000569 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 380394000570 Methyltransferase domain; Region: Methyltransf_26; pfam13659 380394000571 Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: VapC; COG1487 380394000572 putative active site [active] 380394000573 Uncharacterized protein conserved in bacteria (DUF2191); Region: DUF2191; pfam09957 380394000574 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 380394000575 putative acyl-acceptor binding pocket; other site 380394000576 PIN domain; Region: PIN_3; pfam13470 380394000577 DNA binding domain, excisionase family; Region: excise; TIGR01764 380394000578 Antirestriction protein [DNA replication, recombination, and repair]; Region: COG4227 380394000579 Domain of unknown function (DUF1738); Region: DUF1738; pfam08401 380394000580 Protein of unknown function (DUF2958); Region: DUF2958; pfam11171 380394000581 Domain of unknown function (DUF3560); Region: DUF3560; pfam12083 380394000582 protein-export membrane protein SecD; Region: secD; TIGR01129 380394000583 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 380394000584 active site 380394000585 Type IV secretory pathway, VirD2 components (relaxase) [Intracellular trafficking and secretion]; Region: VirD2; COG3843 380394000586 Protein of unknown function (DUF3363); Region: DUF3363; pfam11843 380394000587 P-type conjugative transfer ATPase TrbB; Region: TrbB_P; TIGR02782 380394000588 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 380394000589 ATP binding site [chemical binding]; other site 380394000590 Walker A motif; other site 380394000591 hexamer interface [polypeptide binding]; other site 380394000592 Walker B motif; other site 380394000593 Type IV secretory pathway, VirB3-like protein; Region: VirB3; cl01501 380394000594 conjugal transfer ATPase TrbE; Provisional; Region: PRK13873 380394000595 CagE, TrbE, VirB family, component of type IV transporter system; Region: CagE_TrbE_VirB; pfam03135 380394000596 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 380394000597 Walker B; other site 380394000598 D-loop; other site 380394000599 H-loop/switch region; other site 380394000600 P-type conjugative transfer protein TrbJ; Region: TrbJ_Ti; TIGR02780 380394000601 Conjugal transfer/entry exclusion protein [Intracellular trafficking and secretion]; Region: COG5314 380394000602 P-type conjugative transfer protein TrbL; Region: TrbL_P; TIGR02783 380394000603 Uncharacterized ACR, YggU family COG1872; Region: DUF167; cl00811 380394000604 TIR domain; Region: TIR_2; pfam13676 380394000605 VirB8 protein; Region: VirB8; pfam04335 380394000606 VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cd06911 380394000607 VirB7 interaction site; other site 380394000608 VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cl11423 380394000609 Bacterial conjugation TrbI-like protein; Region: TrbI; pfam03743 380394000610 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 380394000611 N-acetyl-D-glucosamine binding site [chemical binding]; other site 380394000612 catalytic residue [active] 380394000613 Type IV secretion-system coupling protein DNA-binding domain; Region: TrwB_AAD_bind; pfam10412 380394000614 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 380394000615 Walker A motif; other site 380394000616 ATP binding site [chemical binding]; other site 380394000617 Walker B motif; other site 380394000618 lycopene beta cyclase; Region: PLN02463 380394000619 Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668 380394000620 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 380394000621 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 380394000622 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 380394000623 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 380394000624 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 380394000625 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 380394000626 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 380394000627 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 380394000628 PLD-like domain; Region: PLDc_2; pfam13091 380394000629 putative active site [active] 380394000630 catalytic site [active] 380394000631 Putative catalytic domain, repeat 2, of uncharacterized phospholipase D-like proteins; Region: PLDc_unchar1_2; cd09128 380394000632 PLD-like domain; Region: PLDc_2; pfam13091 380394000633 putative active site [active] 380394000634 putative catalytic site [active] 380394000635 ParB-like nuclease domain; Region: ParBc; pfam02195 380394000636 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 380394000637 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 380394000638 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 380394000639 P-loop; other site 380394000640 Magnesium ion binding site [ion binding]; other site 380394000641 conjugal transfer pilin processing protease TraF; Provisional; Region: PRK13838 380394000642 Signal peptidase, peptidase S26; Region: Peptidase_S26; pfam10502 380394000643 conjugal transfer protein TraB; Provisional; Region: PRK13825 380394000644 active site 380394000645 catalytic triad [active] 380394000646 dimer interface [polypeptide binding]; other site 380394000647 active site 380394000648 dimer interface [polypeptide binding]; other site 380394000649 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 380394000650 Predicted transcriptional regulator [Transcription]; Region: COG3636; cl17681 380394000651 DNA topoisomerase III; Provisional; Region: PRK07726 380394000652 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 380394000653 active site 380394000654 putative interdomain interaction site [polypeptide binding]; other site 380394000655 putative metal-binding site [ion binding]; other site 380394000656 putative nucleotide binding site [chemical binding]; other site 380394000657 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 380394000658 domain I; other site 380394000659 DNA binding groove [nucleotide binding] 380394000660 phosphate binding site [ion binding]; other site 380394000661 domain II; other site 380394000662 domain III; other site 380394000663 nucleotide binding site [chemical binding]; other site 380394000664 catalytic site [active] 380394000665 domain IV; other site 380394000666 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 380394000667 active site 380394000668 Domain of unknown function(DUF2779); Region: DUF2779; pfam11074 380394000669 Predicted transcriptional regulator [Transcription]; Region: COG2378 380394000670 WYL domain; Region: WYL; pfam13280 380394000671 Protein of unknown function DUF262; Region: DUF262; pfam03235 380394000672 Uncharacterized conserved protein [Function unknown]; Region: COG1479 380394000673 Predicted protein tyrosine phosphatase [General function prediction only]; Region: COG5350 380394000674 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 380394000675 RT_Bac_retron_II: Reverse transcriptases (RTs) in bacterial retrotransposons or retrons. The polymerase reaction of this enzyme leads to the production of a unique RNA-DNA complex called msDNA (multicopy single-stranded (ss)DNA) in which a small ssDNA...; Region: RT_Bac_retron_II; cd03487 380394000676 putative active site [active] 380394000677 putative NTP binding site [chemical binding]; other site 380394000678 putative nucleic acid binding site [nucleotide binding]; other site 380394000679 Predicted ATP-dependent endonuclease of the OLD family [DNA replication, recombination, and repair]; Region: COG3593 380394000680 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 380394000681 Walker A/P-loop; other site 380394000682 ATP binding site [chemical binding]; other site 380394000683 TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family. The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026 380394000684 putative active site [active] 380394000685 putative metal-binding site [ion binding]; other site 380394000686 AAA domain; Region: AAA_11; pfam13086 380394000687 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 380394000688 NifU-like domain; Region: NifU; cl00484 380394000689 pteridine reductase; Provisional; Region: PRK09135 380394000690 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 380394000691 NAD(P) binding site [chemical binding]; other site 380394000692 active site 380394000693 Uncharacterized conserved protein [Function unknown]; Region: COG1565 380394000694 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; pfam09678 380394000695 Domain of unknown function (DUF4338); Region: DUF4338; pfam14236 380394000696 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 380394000697 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880 380394000698 coproporphyrinogen III oxidase; Provisional; Region: PRK09249 380394000699 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 380394000700 FeS/SAM binding site; other site 380394000701 HemN C-terminal domain; Region: HemN_C; pfam06969 380394000702 Transcriptional regulator [Transcription]; Region: LysR; COG0583 380394000703 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 380394000704 The C-terminal substrate binding domain of LysR-type transcriptional regulator metR, which regulates the expression of methionine biosynthetic genes, contains type 2 periplasmic binding fold; Region: PBP2_MetR; cd08441 380394000705 putative dimerization interface [polypeptide binding]; other site 380394000706 outer membrane porin, OprD family; Region: OprD; pfam03573 380394000707 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880 380394000708 Domain of unknown function (DUF4338); Region: DUF4338; pfam14236 380394000709 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 380394000710 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 380394000711 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 380394000712 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 380394000713 putative active site [active] 380394000714 Uncharacterized ACR, YagE family COG1723; Region: DUF155; cl00751 380394000715 FAD binding domain; Region: FAD_binding_4; pfam01565 380394000716 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 380394000717 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 380394000718 active site 380394000719 dimer interface [polypeptide binding]; other site 380394000720 rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199 380394000721 Cytidylyltransferase; Region: CTP_transf_2; pfam01467 380394000722 active site 380394000723 nucleotide binding site [chemical binding]; other site 380394000724 HIGH motif; other site 380394000725 KMSKS motif; other site 380394000726 hypothetical protein; Reviewed; Region: PRK12497 380394000727 LppC putative lipoprotein; Region: LppC; pfam04348 380394000728 Periplasmic binding component of lipoprotein LppC, an immunodominant antigen; Region: PBP1_YraM_LppC_lipoprotein_like; cd06339 380394000729 putative ligand binding site [chemical binding]; other site 380394000730 Predicted methyltransferases [General function prediction only]; Region: COG0313 380394000731 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 380394000732 putative SAM binding site [chemical binding]; other site 380394000733 putative homodimer interface [polypeptide binding]; other site 380394000734 BRO family, N-terminal domain; Region: Bro-N; cl10591 380394000735 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 380394000736 S-adenosylmethionine binding site [chemical binding]; other site 380394000737 Member of the Rhodanese Homology Domain superfamily, subgroup 1. This CD includes the putative rhodanese-related sulfurtransferases of several uncharacterized proteins; Region: RHOD_1; cd01522 380394000738 active site residue [active] 380394000739 Type II secretory pathway, component ExeA (predicted ATPase) [Intracellular trafficking and secretion]; Region: ExeA; COG3267 380394000740 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 380394000741 Walker A motif; other site 380394000742 ATP binding site [chemical binding]; other site 380394000743 Walker B motif; other site 380394000744 arginine finger; other site 380394000745 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 380394000746 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 380394000747 active site 380394000748 DNA binding site [nucleotide binding] 380394000749 Int/Topo IB signature motif; other site 380394000750 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 380394000751 integron integrase; Region: integrase_gron; TIGR02249 380394000752 active site 380394000753 DNA binding site [nucleotide binding] 380394000754 Int/Topo IB signature motif; other site 380394000755 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 380394000756 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N2; pfam13495 380394000757 INT_SG5, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 5, N- and C-terminal domains. The CD contains mainly predicted bacterial integrase/recombinases; Region: INT_SG5; cd01190 380394000758 Int/Topo IB signature motif; other site 380394000759 Integrase core domain; Region: rve; pfam00665 380394000760 Protein of unknown function (DUF423); Region: DUF423; pfam04241 380394000761 Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_1; cd02432 380394000762 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cl00200 380394000763 amphipathic channel; other site 380394000764 Asn-Pro-Ala signature motifs; other site 380394000765 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 380394000766 catalytic core [active] 380394000767 spermidine synthase; Provisional; Region: PRK00811 380394000768 Spermidine synthase [Amino acid transport and metabolism]; Region: SpeE; COG0421 380394000769 S-adenosylmethionine decarboxylase proenzyme, Bacillus form; Region: SAM_DCase_Bsu; TIGR03330 380394000770 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 380394000771 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 380394000772 Walker A/P-loop; other site 380394000773 ATP binding site [chemical binding]; other site 380394000774 Q-loop/lid; other site 380394000775 ABC transporter signature motif; other site 380394000776 Walker B; other site 380394000777 D-loop; other site 380394000778 H-loop/switch region; other site 380394000779 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 380394000780 Permease; Region: Permease; pfam02405 380394000781 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 380394000782 mce related protein; Region: MCE; pfam02470 380394000783 Toluene tolerance, Ttg2; Region: Tol_Tol_Ttg2; pfam05494 380394000784 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 380394000785 anti sigma factor interaction site; other site 380394000786 regulatory phosphorylation site [posttranslational modification]; other site 380394000787 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 380394000788 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 380394000789 Walker A/P-loop; other site 380394000790 ATP binding site [chemical binding]; other site 380394000791 Q-loop/lid; other site 380394000792 ABC transporter signature motif; other site 380394000793 Walker B; other site 380394000794 D-loop; other site 380394000795 H-loop/switch region; other site 380394000796 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 380394000797 RNA binding surface [nucleotide binding]; other site 380394000798 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 380394000799 4-hydroxythreonine-4-phosphate dehydrogenase; Region: pdxA; TIGR00557 380394000800 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 380394000801 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 380394000802 active site 380394000803 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 380394000804 Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030 380394000805 Putative bacterial sensory transduction regulator; Region: YbjN; cl15834 380394000806 Sporulation related domain; Region: SPOR; cl10051 380394000807 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 380394000808 Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018 380394000809 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 380394000810 active site 380394000811 HIGH motif; other site 380394000812 nucleotide binding site [chemical binding]; other site 380394000813 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 380394000814 KMSK motif region; other site 380394000815 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 380394000816 tRNA binding surface [nucleotide binding]; other site 380394000817 anticodon binding site; other site 380394000818 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 380394000819 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 380394000820 putative substrate translocation pore; other site 380394000821 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 380394000822 aminoethylphosphonate catabolism associated LysR family transcriptional regulator; Region: phn_lysR; TIGR03339 380394000823 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 380394000824 dimerization interface [polypeptide binding]; other site 380394000825 HemK family putative methylases; Region: hemK_fam; TIGR00536 380394000826 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 380394000827 S-adenosylmethionine binding site [chemical binding]; other site 380394000828 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 380394000829 putative catalytic site [active] 380394000830 putative metal binding site [ion binding]; other site 380394000831 putative phosphate binding site [ion binding]; other site 380394000832 Protein involved in catabolism of external DNA [General function prediction only]; Region: ComJ; COG2961 380394000833 putative glutathione S-transferase; Provisional; Region: PRK10357 380394000834 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 380394000835 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 380394000836 N-terminal domain interface [polypeptide binding]; other site 380394000837 dimer interface [polypeptide binding]; other site 380394000838 substrate binding pocket (H-site) [chemical binding]; other site 380394000839 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 380394000840 putative catalytic site [active] 380394000841 putative phosphate binding site [ion binding]; other site 380394000842 active site 380394000843 metal binding site A [ion binding]; metal-binding site 380394000844 DNA binding site [nucleotide binding] 380394000845 putative AP binding site [nucleotide binding]; other site 380394000846 putative metal binding site B [ion binding]; other site 380394000847 ferrochelatase; Reviewed; Region: hemH; PRK00035 380394000848 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 380394000849 C-terminal domain interface [polypeptide binding]; other site 380394000850 active site 380394000851 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 380394000852 active site 380394000853 N-terminal domain interface [polypeptide binding]; other site 380394000854 FKBP-type peptidyl-prolyl cis-trans isomerases 2 [Posttranslational modification, protein turnover, chaperones]; Region: SlpA; COG1047 380394000855 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 380394000856 anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585 380394000857 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 380394000858 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 380394000859 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 380394000860 shikimate binding site; other site 380394000861 NAD(P) binding site [chemical binding]; other site 380394000862 type IV-A pilus assembly ATPase PilB; Region: type_IV_pilB; TIGR02538 380394000863 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 380394000864 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 380394000865 Walker A motif; other site 380394000866 ATP binding site [chemical binding]; other site 380394000867 Walker B motif; other site 380394000868 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 380394000869 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 380394000870 dimer interface [polypeptide binding]; other site 380394000871 phosphorylation site [posttranslational modification] 380394000872 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 380394000873 ATP binding site [chemical binding]; other site 380394000874 Mg2+ binding site [ion binding]; other site 380394000875 G-X-G motif; other site 380394000876 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 380394000877 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 380394000878 active site 380394000879 phosphorylation site [posttranslational modification] 380394000880 intermolecular recognition site; other site 380394000881 dimerization interface [polypeptide binding]; other site 380394000882 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 380394000883 Walker A motif; other site 380394000884 ATP binding site [chemical binding]; other site 380394000885 Walker B motif; other site 380394000886 arginine finger; other site 380394000887 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 380394000888 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 380394000889 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 380394000890 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 380394000891 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 380394000892 CoA-binding site [chemical binding]; other site 380394000893 ATP-binding [chemical binding]; other site 380394000894 Protein of unknown function (DUF1342); Region: DUF1342; cl01892 380394000895 Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354 380394000896 AMP binding site [chemical binding]; other site 380394000897 metal binding site [ion binding]; metal-binding site 380394000898 active site 380394000899 Stringent starvation protein B; Region: SspB; cl01120 380394000900 Domain of unknown function (DUF4124); Region: DUF4124; pfam13511 380394000901 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 380394000902 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 380394000903 N-acetyl-D-glucosamine binding site [chemical binding]; other site 380394000904 catalytic residue [active] 380394000905 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 380394000906 zinc-ribbon domain; Region: zinc_ribbon_5; pfam13719 380394000907 Protein of unknown function (DUF3426); Region: DUF3426; pfam11906 380394000908 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 380394000909 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 380394000910 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 380394000911 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 380394000912 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 380394000913 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 380394000914 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 380394000915 carboxyltransferase (CT) interaction site; other site 380394000916 biotinylation site [posttranslational modification]; other site 380394000917 Dehydroquinase class II; Region: DHquinase_II; pfam01220 380394000918 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 380394000919 trimer interface [polypeptide binding]; other site 380394000920 active site 380394000921 dimer interface [polypeptide binding]; other site 380394000922 Predicted transcriptional regulators [Transcription]; Region: COG1733 380394000923 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 380394000924 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 380394000925 dinuclear metal binding motif [ion binding]; other site 380394000926 cell division protein FtsZ; Validated; Region: PRK09330 380394000927 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 380394000928 nucleotide binding site [chemical binding]; other site 380394000929 SulA interaction site; other site 380394000930 cell division protein FtsA; Region: ftsA; TIGR01174 380394000931 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 380394000932 nucleotide binding site [chemical binding]; other site 380394000933 SHS2 domain inserted in FTSA; Region: SHS2_FTSA; pfam02491 380394000934 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 380394000935 Cell division protein FtsA; Region: FtsA; pfam14450 380394000936 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 380394000937 Cell division protein FtsQ; Region: FtsQ; pfam03799 380394000938 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 380394000939 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 380394000940 ATP-grasp domain; Region: ATP-grasp_4; cl17255 380394000941 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 380394000942 FAD binding domain; Region: FAD_binding_4; pfam01565 380394000943 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 380394000944 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 380394000945 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 380394000946 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 380394000947 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 380394000948 undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase; Region: murG; TIGR01133 380394000949 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 380394000950 active site 380394000951 homodimer interface [polypeptide binding]; other site 380394000952 cell division protein FtsW; Region: ftsW; TIGR02614 380394000953 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK03803 380394000954 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 380394000955 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 380394000956 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 380394000957 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 380394000958 Mg++ binding site [ion binding]; other site 380394000959 putative catalytic motif [active] 380394000960 putative substrate binding site [chemical binding]; other site 380394000961 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 380394000962 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 380394000963 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 380394000964 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 380394000965 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 380394000966 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 380394000967 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 380394000968 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 380394000969 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 380394000970 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 380394000971 Cell division protein FtsL; Region: FtsL; pfam04999 380394000972 MraW methylase family; Region: Methyltransf_5; cl17771 380394000973 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 380394000974 cell division protein MraZ; Reviewed; Region: PRK00326 380394000975 MraZ protein; Region: MraZ; pfam02381 380394000976 MraZ protein; Region: MraZ; pfam02381 380394000977 tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617 380394000978 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 380394000979 metal binding triad [ion binding]; metal-binding site 380394000980 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 380394000981 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 380394000982 Zn2+ binding site [ion binding]; other site 380394000983 Mg2+ binding site [ion binding]; other site 380394000984 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 380394000985 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 380394000986 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 380394000987 acyl-activating enzyme (AAE) consensus motif; other site 380394000988 acyl-activating enzyme (AAE) consensus motif; other site 380394000989 putative AMP binding site [chemical binding]; other site 380394000990 putative active site [active] 380394000991 putative CoA binding site [chemical binding]; other site 380394000992 stringent starvation protein A; Provisional; Region: sspA; PRK09481 380394000993 GST_N family, Stringent starvation protein A (SspA) subfamily; SspA is a RNA polymerase (RNAP)-associated protein required for the lytic development of phage P1 and for stationary phase-induced acid tolerance of E. coli. It is implicated in survival...; Region: GST_N_SspA; cd03059 380394000994 C-terminal domain interface [polypeptide binding]; other site 380394000995 putative GSH binding site (G-site) [chemical binding]; other site 380394000996 dimer interface [polypeptide binding]; other site 380394000997 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 380394000998 N-terminal domain interface [polypeptide binding]; other site 380394000999 dimer interface [polypeptide binding]; other site 380394001000 substrate binding pocket (H-site) [chemical binding]; other site 380394001001 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186 380394001002 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 380394001003 Protein of unknown function (DUF721); Region: DUF721; cl02324 380394001004 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 380394001005 DEAD/DEAH box helicase; Region: DEAD; pfam00270 380394001006 ATP binding site [chemical binding]; other site 380394001007 putative Mg++ binding site [ion binding]; other site 380394001008 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 380394001009 SEC-C motif; Region: SEC-C; pfam02810 380394001010 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 380394001011 heterotetramer interface [polypeptide binding]; other site 380394001012 active site pocket [active] 380394001013 cleavage site 380394001014 hypothetical protein; Provisional; Region: PRK08999 380394001015 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 380394001016 active site 380394001017 8-oxo-dGMP binding site [chemical binding]; other site 380394001018 nudix motif; other site 380394001019 metal binding site [ion binding]; metal-binding site 380394001020 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 380394001021 thiamine phosphate binding site [chemical binding]; other site 380394001022 active site 380394001023 pyrophosphate binding site [ion binding]; other site 380394001024 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 380394001025 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 380394001026 Ligand binding site; other site 380394001027 Putative Catalytic site; other site 380394001028 DXD motif; other site 380394001029 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 380394001030 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 380394001031 putative active site [active] 380394001032 putative metal binding site [ion binding]; other site 380394001033 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 380394001034 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 380394001035 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 380394001036 O-Antigen ligase; Region: Wzy_C; pfam04932 380394001037 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 380394001038 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 380394001039 Probable Catalytic site; other site 380394001040 metal-binding site 380394001041 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 380394001042 putative metal binding site; other site 380394001043 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 380394001044 ADP-heptose:LPS heptosyl transferase I; Provisional; Region: PRK10964; cl15782 380394001045 Protein tyrosine/serine phosphatase [Signal transduction mechanisms]; Region: COG2365 380394001046 3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749 380394001047 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 380394001048 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 380394001049 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 380394001050 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 380394001051 putative acyl-acceptor binding pocket; other site 380394001052 putative C-S lyase; Region: C_S_lyase_PatB; TIGR04350 380394001053 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 380394001054 pyridoxal 5'-phosphate binding site [chemical binding]; other site 380394001055 homodimer interface [polypeptide binding]; other site 380394001056 catalytic residue [active] 380394001057 5-histidylcysteine sulfoxide synthase; Region: ovoA_Nterm; TIGR04344 380394001058 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 380394001059 Methyltransferase domain; Region: Methyltransf_31; pfam13847 380394001060 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 380394001061 S-adenosylmethionine binding site [chemical binding]; other site 380394001062 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 380394001063 comF family protein; Region: comF; TIGR00201 380394001064 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 380394001065 active site 380394001066 8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958 380394001067 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 380394001068 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 380394001069 catalytic residue [active] 380394001070 pimelyl-[acyl-carrier protein] methyl ester esterase; Region: bioH; TIGR01738 380394001071 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 380394001072 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 380394001073 S-adenosylmethionine binding site [chemical binding]; other site 380394001074 Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132 380394001075 AAA domain; Region: AAA_26; pfam13500 380394001076 Peptidase family M48; Region: Peptidase_M48; cl12018 380394001077 leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301 380394001078 arginyl-tRNA-protein transferase; Provisional; Region: PRK01305 380394001079 Arginine-tRNA-protein transferase, N terminus; Region: ATE_N; pfam04376 380394001080 Arginine-tRNA-protein transferase, C terminus; Region: ATE_C; pfam04377 380394001081 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390 380394001082 ribonuclease T; Provisional; Region: PRK05168 380394001083 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 380394001084 active site 380394001085 catalytic site [active] 380394001086 substrate binding site [chemical binding]; other site 380394001087 CDP-6-deoxy-delta-3,4-glucoseen reductase; Validated; Region: PRK07609 380394001088 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 380394001089 catalytic loop [active] 380394001090 iron binding site [ion binding]; other site 380394001091 NAD(P)H dependent flavin oxidoreductases use flavin as a substrate in mediating electron transfer from iron complexes or iron proteins. Structurally similar to ferredoxin reductases, but with only 15% sequence identity, flavin reductases reduce FAD, FMN; Region: flavin_oxioreductase; cd06189 380394001092 FAD binding pocket [chemical binding]; other site 380394001093 FAD binding motif [chemical binding]; other site 380394001094 phosphate binding motif [ion binding]; other site 380394001095 beta-alpha-beta structure motif; other site 380394001096 NAD binding pocket [chemical binding]; other site 380394001097 Putative zinc ribbon domain; Region: Zn_ribbon_2; pfam12674 380394001098 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 380394001099 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 380394001100 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 380394001101 feedback inhibition sensing region; other site 380394001102 homohexameric interface [polypeptide binding]; other site 380394001103 nucleotide binding site [chemical binding]; other site 380394001104 N-acetyl-L-glutamate binding site [chemical binding]; other site 380394001105 efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998 380394001106 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 380394001107 HlyD family secretion protein; Region: HlyD_3; pfam13437 380394001108 Lipid A 3-O-deacylase (PagL); Region: PagL; pfam09411 380394001109 biotin synthase; Region: bioB; TIGR00433 380394001110 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 380394001111 FeS/SAM binding site; other site 380394001112 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 380394001113 Uncharacterized ACR, YggU family COG1872; Region: DUF167; cl00811 380394001114 YGGT family; Region: YGGT; pfam02325 380394001115 Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345 380394001116 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 380394001117 Pyridoxal 5-phosphate (PLP)-binding TIM barrel domain of Type III PLP-Dependent Enzymes, Yggs-like proteins; Region: PLPDE_III_Yggs_like; cd06824 380394001118 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 380394001119 catalytic residue [active] 380394001120 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 380394001121 Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131 380394001122 Walker A motif; other site 380394001123 ATP binding site [chemical binding]; other site 380394001124 Walker B motif; other site 380394001125 Tfp pilus assembly protein, ATPase PilU [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilU; COG5008 380394001126 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 380394001127 Walker A motif; other site 380394001128 ATP binding site [chemical binding]; other site 380394001129 Walker B motif; other site 380394001130 hopene-associated glycosyltransferase HpnB; Region: HpnB; TIGR03469 380394001131 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 380394001132 DXD motif; other site 380394001133 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 380394001134 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 380394001135 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 380394001136 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 380394001137 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 380394001138 ligand binding site [chemical binding]; other site 380394001139 flexible hinge region; other site 380394001140 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 380394001141 putative switch regulator; other site 380394001142 non-specific DNA interactions [nucleotide binding]; other site 380394001143 DNA binding site [nucleotide binding] 380394001144 sequence specific DNA binding site [nucleotide binding]; other site 380394001145 putative cAMP binding site [chemical binding]; other site 380394001146 tRNA (guanine-N(7)-)-methyltransferase; Reviewed; Region: trmB; PRK00121 380394001147 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 380394001148 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 380394001149 ATP-grasp domain; Region: ATP-grasp; pfam02222 380394001150 Disulfide bond formation protein DsbB; Region: DsbB; pfam02600 380394001151 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 380394001152 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 380394001153 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 380394001154 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 380394001155 SmpB-tmRNA interface; other site 380394001156 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 380394001157 putative active site [active] 380394001158 catalytic site [active] 380394001159 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 380394001160 putative active site [active] 380394001161 catalytic site [active] 380394001162 Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813 380394001163 putative coenzyme Q binding site [chemical binding]; other site 380394001164 Outer membrane lipoprotein OmlA (small protein A) [Cell envelope biogenesis, outer membrane]; Region: OlmA; COG2913 380394001165 SmpA / OmlA family; Region: SmpA_OmlA; pfam04355 380394001166 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 380394001167 metal binding site 2 [ion binding]; metal-binding site 380394001168 putative DNA binding helix; other site 380394001169 metal binding site 1 [ion binding]; metal-binding site 380394001170 dimer interface [polypeptide binding]; other site 380394001171 structural Zn2+ binding site [ion binding]; other site 380394001172 gamma-glutamyl kinase; Provisional; Region: PRK05429 380394001173 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 380394001174 nucleotide binding site [chemical binding]; other site 380394001175 homotetrameric interface [polypeptide binding]; other site 380394001176 putative phosphate binding site [ion binding]; other site 380394001177 putative allosteric binding site; other site 380394001178 PUA domain; Region: PUA; pfam01472 380394001179 Obg family GTPase CgtA; Region: Obg_CgtA; TIGR02729 380394001180 GTP1/OBG; Region: GTP1_OBG; pfam01018 380394001181 Obg GTPase; Region: Obg; cd01898 380394001182 G1 box; other site 380394001183 GTP/Mg2+ binding site [chemical binding]; other site 380394001184 Switch I region; other site 380394001185 G2 box; other site 380394001186 G3 box; other site 380394001187 Switch II region; other site 380394001188 G4 box; other site 380394001189 G5 box; other site 380394001190 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 380394001191 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 380394001192 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 380394001193 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 380394001194 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 380394001195 Sulfate transporter family; Region: Sulfate_transp; pfam00916 380394001196 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884 380394001197 active site clefts [active] 380394001198 zinc binding site [ion binding]; other site 380394001199 dimer interface [polypeptide binding]; other site 380394001200 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 380394001201 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 380394001202 THF binding site; other site 380394001203 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 380394001204 substrate binding site [chemical binding]; other site 380394001205 THF binding site; other site 380394001206 zinc-binding site [ion binding]; other site 380394001207 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 380394001208 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 380394001209 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 380394001210 Glutathione S-transferase, N-terminal domain; Region: GST_N_3; pfam13417 380394001211 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 380394001212 N-terminal domain interface [polypeptide binding]; other site 380394001213 dimer interface [polypeptide binding]; other site 380394001214 substrate binding pocket (H-site) [chemical binding]; other site 380394001215 Methyltransferase domain; Region: Methyltransf_31; pfam13847 380394001216 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 380394001217 S-adenosylmethionine binding site [chemical binding]; other site 380394001218 homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175 380394001219 homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392 380394001220 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 380394001221 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 380394001222 dimer interface [polypeptide binding]; other site 380394001223 active site 380394001224 glycine-pyridoxal phosphate binding site [chemical binding]; other site 380394001225 folate binding site [chemical binding]; other site 380394001226 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 380394001227 zinc-ribbon domain; Region: zinc_ribbon_5; cl11777 380394001228 ATP cone domain; Region: ATP-cone; pfam03477 380394001229 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 380394001230 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 380394001231 catalytic motif [active] 380394001232 Zn binding site [ion binding]; other site 380394001233 RibD C-terminal domain; Region: RibD_C; cl17279 380394001234 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 380394001235 Lumazine binding domain; Region: Lum_binding; pfam00677 380394001236 Lumazine binding domain; Region: Lum_binding; pfam00677 380394001237 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II-like protein; Provisional; Region: PRK14019 380394001238 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 380394001239 GTP cyclohydrolase II; Region: GTP_cyclohydro2; pfam00925 380394001240 dimerization interface [polypeptide binding]; other site 380394001241 active site 380394001242 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 380394001243 homopentamer interface [polypeptide binding]; other site 380394001244 active site 380394001245 transcription antitermination factor NusB; Region: nusB; TIGR01951 380394001246 Protein of unknown function (DUF2934); Region: DUF2934; pfam11154 380394001247 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 380394001248 Sel1 repeat; Region: Sel1; cl02723 380394001249 Sel1-like repeats; Region: SEL1; smart00671 380394001250 Protein of unknown function (DUF1049); Region: DUF1049; pfam06305 380394001251 ABC1 family; Region: ABC1; cl17513 380394001252 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 380394001253 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 380394001254 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 380394001255 ligand binding site [chemical binding]; other site 380394001256 elongation factor Tu; Reviewed; Region: PRK12735 380394001257 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 380394001258 G1 box; other site 380394001259 GEF interaction site [polypeptide binding]; other site 380394001260 GTP/Mg2+ binding site [chemical binding]; other site 380394001261 Switch I region; other site 380394001262 G2 box; other site 380394001263 G3 box; other site 380394001264 Switch II region; other site 380394001265 G4 box; other site 380394001266 G5 box; other site 380394001267 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 380394001268 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 380394001269 Antibiotic Binding Site [chemical binding]; other site 380394001270 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK05740 380394001271 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 380394001272 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 380394001273 putative homodimer interface [polypeptide binding]; other site 380394001274 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 380394001275 heterodimer interface [polypeptide binding]; other site 380394001276 homodimer interface [polypeptide binding]; other site 380394001277 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 380394001278 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 380394001279 23S rRNA interface [nucleotide binding]; other site 380394001280 L7/L12 interface [polypeptide binding]; other site 380394001281 putative thiostrepton binding site; other site 380394001282 L25 interface [polypeptide binding]; other site 380394001283 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 380394001284 mRNA/rRNA interface [nucleotide binding]; other site 380394001285 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 380394001286 23S rRNA interface [nucleotide binding]; other site 380394001287 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 380394001288 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 380394001289 core dimer interface [polypeptide binding]; other site 380394001290 peripheral dimer interface [polypeptide binding]; other site 380394001291 L10 interface [polypeptide binding]; other site 380394001292 L11 interface [polypeptide binding]; other site 380394001293 putative EF-Tu interaction site [polypeptide binding]; other site 380394001294 putative EF-G interaction site [polypeptide binding]; other site 380394001295 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 380394001296 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 380394001297 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 380394001298 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 380394001299 RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562 380394001300 Domain of unknown function (DUF1845); Region: DUF1845; cl07481 380394001301 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 380394001302 RPB3 interaction site [polypeptide binding]; other site 380394001303 RPB1 interaction site [polypeptide binding]; other site 380394001304 RPB11 interaction site [polypeptide binding]; other site 380394001305 RPB10 interaction site [polypeptide binding]; other site 380394001306 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 380394001307 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 380394001308 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 380394001309 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 380394001310 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 380394001311 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 380394001312 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 380394001313 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 380394001314 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 380394001315 DNA binding site [nucleotide binding] 380394001316 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 380394001317 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 380394001318 S17 interaction site [polypeptide binding]; other site 380394001319 S8 interaction site; other site 380394001320 16S rRNA interaction site [nucleotide binding]; other site 380394001321 streptomycin interaction site [chemical binding]; other site 380394001322 23S rRNA interaction site [nucleotide binding]; other site 380394001323 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 380394001324 30S ribosomal protein S7; Validated; Region: PRK05302 380394001325 elongation factor G; Reviewed; Region: PRK00007 380394001326 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 380394001327 G1 box; other site 380394001328 putative GEF interaction site [polypeptide binding]; other site 380394001329 GTP/Mg2+ binding site [chemical binding]; other site 380394001330 Switch I region; other site 380394001331 G2 box; other site 380394001332 G3 box; other site 380394001333 Switch II region; other site 380394001334 G4 box; other site 380394001335 G5 box; other site 380394001336 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 380394001337 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 380394001338 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 380394001339 elongation factor Tu; Reviewed; Region: PRK12735 380394001340 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 380394001341 G1 box; other site 380394001342 GEF interaction site [polypeptide binding]; other site 380394001343 GTP/Mg2+ binding site [chemical binding]; other site 380394001344 Switch I region; other site 380394001345 G2 box; other site 380394001346 G3 box; other site 380394001347 Switch II region; other site 380394001348 G4 box; other site 380394001349 G5 box; other site 380394001350 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 380394001351 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 380394001352 Antibiotic Binding Site [chemical binding]; other site 380394001353 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 380394001354 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 380394001355 50S ribosomal protein L4, bacterial/organelle; Region: rplD_bact; TIGR03953 380394001356 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 380394001357 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 380394001358 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 380394001359 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 380394001360 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 380394001361 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 380394001362 protein-rRNA interface [nucleotide binding]; other site 380394001363 putative translocon binding site; other site 380394001364 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 380394001365 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 380394001366 G-X-X-G motif; other site 380394001367 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 380394001368 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 380394001369 23S rRNA interface [nucleotide binding]; other site 380394001370 5S rRNA interface [nucleotide binding]; other site 380394001371 putative antibiotic binding site [chemical binding]; other site 380394001372 L25 interface [polypeptide binding]; other site 380394001373 L27 interface [polypeptide binding]; other site 380394001374 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 380394001375 putative translocon interaction site; other site 380394001376 signal recognition particle (SRP54) interaction site; other site 380394001377 L23 interface [polypeptide binding]; other site 380394001378 trigger factor interaction site; other site 380394001379 23S rRNA interface [nucleotide binding]; other site 380394001380 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 380394001381 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 380394001382 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 380394001383 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 380394001384 RNA binding site [nucleotide binding]; other site 380394001385 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 380394001386 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 380394001387 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 380394001388 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 380394001389 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 380394001390 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 380394001391 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 380394001392 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 380394001393 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 380394001394 5S rRNA interface [nucleotide binding]; other site 380394001395 23S rRNA interface [nucleotide binding]; other site 380394001396 L5 interface [polypeptide binding]; other site 380394001397 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 380394001398 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 380394001399 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 380394001400 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 380394001401 23S rRNA binding site [nucleotide binding]; other site 380394001402 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 380394001403 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 380394001404 SecY translocase; Region: SecY; pfam00344 380394001405 adenylate kinase; Reviewed; Region: adk; PRK00279 380394001406 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 380394001407 AMP-binding site [chemical binding]; other site 380394001408 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 380394001409 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 380394001410 rRNA binding site [nucleotide binding]; other site 380394001411 predicted 30S ribosome binding site; other site 380394001412 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 380394001413 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 380394001414 30S ribosomal protein S13; Region: bact_S13; TIGR03631 380394001415 30S ribosomal protein S11; Validated; Region: PRK05309 380394001416 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 380394001417 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 380394001418 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 380394001419 RNA binding surface [nucleotide binding]; other site 380394001420 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 380394001421 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 380394001422 alphaNTD homodimer interface [polypeptide binding]; other site 380394001423 alphaNTD - beta interaction site [polypeptide binding]; other site 380394001424 alphaNTD - beta' interaction site [polypeptide binding]; other site 380394001425 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 380394001426 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 380394001427 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 380394001428 trimer interface [polypeptide binding]; other site 380394001429 active site 380394001430 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 380394001431 Flavoprotein; Region: Flavoprotein; pfam02441 380394001432 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 380394001433 hypothetical protein; Reviewed; Region: PRK00024 380394001434 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 380394001435 MPN+ (JAMM) motif; other site 380394001436 Zinc-binding site [ion binding]; other site 380394001437 Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; pfam01219 380394001438 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 380394001439 active site 380394001440 UDP-glycosyltransferase; Region: PLN02534 380394001441 DsrE/DsrF/DrsH-like family; Region: DrsE_2; cl17453 380394001442 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 380394001443 active site 380394001444 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 380394001445 glutathione reductase; Validated; Region: PRK06116 380394001446 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 380394001447 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 380394001448 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 380394001449 Peroxiredoxin (PRX) family, PRX5-like subfamily; members are similar to the human protein, PRX5, a homodimeric TRX peroxidase, widely expressed in tissues and found cellularly in mitochondria, peroxisomes and the cytosol. The cellular location of PRX5...; Region: PRX5_like; cd03013 380394001450 catalytic triad [active] 380394001451 dimer interface [polypeptide binding]; other site 380394001452 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 380394001453 phosphoserine phosphatase SerB; Region: serB; TIGR00338 380394001454 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 380394001455 motif II; other site 380394001456 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 380394001457 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; pfam02559 380394001458 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 380394001459 ATP binding site [chemical binding]; other site 380394001460 putative Mg++ binding site [ion binding]; other site 380394001461 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 380394001462 nucleotide binding region [chemical binding]; other site 380394001463 ATP-binding site [chemical binding]; other site 380394001464 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 380394001465 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 380394001466 substrate binding site; other site 380394001467 dimer interface; other site 380394001468 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 380394001469 homotrimer interaction site [polypeptide binding]; other site 380394001470 zinc binding site [ion binding]; other site 380394001471 CDP-binding sites; other site 380394001472 tRNA pseudouridine synthase D; Reviewed; Region: truD; PRK00984 380394001473 Pseudouridine synthase, similar to Escherichia coli TruD; Region: PseudoU_synth_EcTruD; cd02575 380394001474 Permutation of conserved domain; other site 380394001475 active site 380394001476 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 380394001477 Helix-Turn-Helix DNA binding domain of Heavy Metal Resistance transcription regulators; Region: HTH_HMRTR; cd04770 380394001478 DNA binding residues [nucleotide binding] 380394001479 zinc-responsive transcriptional regulator; Provisional; Region: zntR; PRK09514 380394001480 dimer interface [polypeptide binding]; other site 380394001481 metal binding site [ion binding]; metal-binding site 380394001482 Smr domain; Region: Smr; pfam01713 380394001483 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 380394001484 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 380394001485 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 380394001486 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 380394001487 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 380394001488 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 380394001489 lipoprotein chaperone; Reviewed; Region: lolA; PRK00031 380394001490 Outer membrane lipoprotein carrier protein LolA; Region: LolA; pfam03548 380394001491 Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; cl17479 380394001492 Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; cl17479 380394001493 recombination factor protein RarA; Reviewed; Region: PRK13342 380394001494 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 380394001495 Walker A motif; other site 380394001496 ATP binding site [chemical binding]; other site 380394001497 Walker B motif; other site 380394001498 arginine finger; other site 380394001499 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 380394001500 seryl-tRNA synthetase; Provisional; Region: PRK05431 380394001501 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 380394001502 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 380394001503 dimer interface [polypeptide binding]; other site 380394001504 active site 380394001505 motif 1; other site 380394001506 motif 2; other site 380394001507 motif 3; other site 380394001508 Modulator of Rho-dependent transcription termination (ROF); Region: ROF; cl09210 380394001509 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 380394001510 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 380394001511 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 380394001512 ribosome maturation protein RimP; Reviewed; Region: PRK00092 380394001513 Sm and related proteins; Region: Sm_like; cl00259 380394001514 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 380394001515 putative oligomer interface [polypeptide binding]; other site 380394001516 putative RNA binding site [nucleotide binding]; other site 380394001517 transcription elongation factor NusA; Validated; Region: nusA; PRK09202 380394001518 NusA N-terminal domain; Region: NusA_N; pfam08529 380394001519 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 380394001520 RNA binding site [nucleotide binding]; other site 380394001521 homodimer interface [polypeptide binding]; other site 380394001522 NusA-like KH domain; Region: KH_5; pfam13184 380394001523 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 380394001524 G-X-X-G motif; other site 380394001525 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 380394001526 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 380394001527 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 380394001528 Bacterial translation initiation factor IF-2 associated region; Region: IF2_assoc; pfam08364 380394001529 translation initiation factor IF-2; Region: IF-2; TIGR00487 380394001530 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 380394001531 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 380394001532 G1 box; other site 380394001533 putative GEF interaction site [polypeptide binding]; other site 380394001534 GTP/Mg2+ binding site [chemical binding]; other site 380394001535 Switch I region; other site 380394001536 G2 box; other site 380394001537 G3 box; other site 380394001538 Switch II region; other site 380394001539 G4 box; other site 380394001540 G5 box; other site 380394001541 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 380394001542 Translation-initiation factor 2; Region: IF-2; pfam11987 380394001543 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 380394001544 Ribosome-binding factor A; Region: RBFA; pfam02033 380394001545 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05033 380394001546 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 380394001547 RNA binding site [nucleotide binding]; other site 380394001548 active site 380394001549 Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157 380394001550 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 380394001551 16S/18S rRNA binding site [nucleotide binding]; other site 380394001552 S13e-L30e interaction site [polypeptide binding]; other site 380394001553 25S rRNA binding site [nucleotide binding]; other site 380394001554 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 380394001555 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 380394001556 RNase E interface [polypeptide binding]; other site 380394001557 trimer interface [polypeptide binding]; other site 380394001558 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 380394001559 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 380394001560 RNase E interface [polypeptide binding]; other site 380394001561 trimer interface [polypeptide binding]; other site 380394001562 active site 380394001563 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 380394001564 putative nucleic acid binding region [nucleotide binding]; other site 380394001565 G-X-X-G motif; other site 380394001566 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 380394001567 RNA binding site [nucleotide binding]; other site 380394001568 domain interface; other site 380394001569 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 380394001570 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 380394001571 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 380394001572 hydroxyacylglutathione hydrolase; Region: GSH_gloB; TIGR03413 380394001573 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 380394001574 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 380394001575 RNA/DNA hybrid binding site [nucleotide binding]; other site 380394001576 active site 380394001577 DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406 380394001578 DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131 380394001579 active site 380394001580 catalytic site [active] 380394001581 substrate binding site [chemical binding]; other site 380394001582 Roadblock/LC7 domain; Region: Robl_LC7; cl00886 380394001583 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 380394001584 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 380394001585 dimer interface [polypeptide binding]; other site 380394001586 active site 380394001587 metal binding site [ion binding]; metal-binding site 380394001588 glutathione binding site [chemical binding]; other site 380394001589 Protein of unknown function (DUF1255); Region: DUF1255; cl01202 380394001590 argininosuccinate synthase; Provisional; Region: PRK13820 380394001591 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 380394001592 ANP binding site [chemical binding]; other site 380394001593 Substrate Binding Site II [chemical binding]; other site 380394001594 Substrate Binding Site I [chemical binding]; other site 380394001595 ornithine carbamoyltransferase; Provisional; Region: PRK00779 380394001596 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 380394001597 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 380394001598 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 380394001599 acetylornithine aminotransferase; Provisional; Region: PRK02627 380394001600 inhibitor-cofactor binding pocket; inhibition site 380394001601 pyridoxal 5'-phosphate binding site [chemical binding]; other site 380394001602 catalytic residue [active] 380394001603 aspartate kinase; Reviewed; Region: PRK06635 380394001604 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 380394001605 putative nucleotide binding site [chemical binding]; other site 380394001606 putative catalytic residues [active] 380394001607 putative Mg ion binding site [ion binding]; other site 380394001608 putative aspartate binding site [chemical binding]; other site 380394001609 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 380394001610 putative allosteric regulatory site; other site 380394001611 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 380394001612 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 380394001613 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 380394001614 Sel1-like repeats; Region: SEL1; smart00671 380394001615 Plasmid encoded toxin Txe; Region: Plasmid_Txe; cl17389 380394001616 PIN domain of the VapC-like Sll0205 protein and homologs; Region: PIN_Sll0205; cd09872 380394001617 putative active site [active] 380394001618 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 380394001619 Transaldolase-like proteins from plants and bacteria; Region: Transaldolase_like; cd00955 380394001620 putative active site [active] 380394001621 transaldolase; Provisional; Region: PRK03903 380394001622 catalytic residue [active] 380394001623 Enoyl-[acyl-carrier-protein]; Region: FabI; COG0623 380394001624 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 380394001625 NAD binding site [chemical binding]; other site 380394001626 homotetramer interface [polypeptide binding]; other site 380394001627 homodimer interface [polypeptide binding]; other site 380394001628 substrate binding site [chemical binding]; other site 380394001629 active site 380394001630 membrane-bound lytic murein transglycosylase D; Provisional; Region: mltD; PRK10783 380394001631 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 380394001632 N-acetyl-D-glucosamine binding site [chemical binding]; other site 380394001633 catalytic residue [active] 380394001634 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 380394001635 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 380394001636 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 380394001637 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 380394001638 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 380394001639 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 380394001640 HIGH motif; other site 380394001641 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 380394001642 active site 380394001643 KMSKS motif; other site 380394001644 aconitate hydratase; Validated; Region: PRK07229 380394001645 Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: AcnA_Bact; cd01585 380394001646 substrate binding site [chemical binding]; other site 380394001647 ligand binding site [chemical binding]; other site 380394001648 Bacterial Aconitase-like swivel domain. Aconitase (aconitate hydratase or citrate hydrolyase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. Cis-aconitate is formed as an intermediate product during the course...; Region: AcnA_Bact_Swivel; cd01579 380394001649 substrate binding site [chemical binding]; other site 380394001650 isocitrate dehydrogenase; Validated; Region: PRK07362 380394001651 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 380394001652 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 380394001653 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 380394001654 CoA-ligase; Region: Ligase_CoA; pfam00549 380394001655 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 380394001656 CoA binding domain; Region: CoA_binding; pfam02629 380394001657 CoA-ligase; Region: Ligase_CoA; pfam00549 380394001658 NAD synthetase; Provisional; Region: PRK13981 380394001659 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 380394001660 multimer interface [polypeptide binding]; other site 380394001661 active site 380394001662 catalytic triad [active] 380394001663 protein interface 1 [polypeptide binding]; other site 380394001664 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 380394001665 homodimer interface [polypeptide binding]; other site 380394001666 NAD binding pocket [chemical binding]; other site 380394001667 ATP binding pocket [chemical binding]; other site 380394001668 Mg binding site [ion binding]; other site 380394001669 active-site loop [active] 380394001670 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 380394001671 Nitrogen regulatory protein P-II; Region: P-II; smart00938 380394001672 outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302 380394001673 23S rRNA pseudouridine synthase D; Provisional; Region: rluD; PRK11180 380394001674 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 380394001675 RNA binding surface [nucleotide binding]; other site 380394001676 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 380394001677 active site 380394001678 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 380394001679 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; cl00650 380394001680 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1791 380394001681 Cupin domain; Region: Cupin_2; pfam07883 380394001682 Ribulose bisphosphate carboxylase large chain; Region: RuBisCO_large; cl08232 380394001683 dimer interface [polypeptide binding]; other site 380394001684 2,3-diketo-5-methylthiopentyl-1-phosphate enolase; Reviewed; Region: mtnW; PRK09549 380394001685 catalytic residue [active] 380394001686 metal binding site [ion binding]; metal-binding site 380394001687 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 380394001688 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 380394001689 motif II; other site 380394001690 methylthioribulose-1-phosphate dehydratase; Region: salvage_mtnB; TIGR03328 380394001691 intersubunit interface [polypeptide binding]; other site 380394001692 active site 380394001693 Zn2+ binding site [ion binding]; other site 380394001694 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 380394001695 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 380394001696 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 380394001697 active site 380394001698 catalytic residues [active] 380394001699 metal binding site [ion binding]; metal-binding site 380394001700 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 380394001701 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 380394001702 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 380394001703 NAD binding site [chemical binding]; other site 380394001704 substrate binding site [chemical binding]; other site 380394001705 homodimer interface [polypeptide binding]; other site 380394001706 active site 380394001707 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 380394001708 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 380394001709 NADP binding site [chemical binding]; other site 380394001710 active site 380394001711 putative substrate binding site [chemical binding]; other site 380394001712 Protein of unknown function (DUF3579); Region: DUF3579; pfam12112 380394001713 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 380394001714 active site 380394001715 tetramer interface; other site 380394001716 Protein of unknown function (DUF502); Region: DUF502; cl01107 380394001717 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 380394001718 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 380394001719 active site 380394001720 phosphorylation site [posttranslational modification] 380394001721 intermolecular recognition site; other site 380394001722 dimerization interface [polypeptide binding]; other site 380394001723 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 380394001724 Walker A motif; other site 380394001725 ATP binding site [chemical binding]; other site 380394001726 Walker B motif; other site 380394001727 arginine finger; other site 380394001728 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 380394001729 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 380394001730 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 380394001731 dimerization interface [polypeptide binding]; other site 380394001732 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 380394001733 dimer interface [polypeptide binding]; other site 380394001734 phosphorylation site [posttranslational modification] 380394001735 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 380394001736 ATP binding site [chemical binding]; other site 380394001737 Mg2+ binding site [ion binding]; other site 380394001738 G-X-G motif; other site 380394001739 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 380394001740 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 380394001741 Walker A/P-loop; other site 380394001742 ATP binding site [chemical binding]; other site 380394001743 Q-loop/lid; other site 380394001744 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 380394001745 Q-loop/lid; other site 380394001746 ABC transporter signature motif; other site 380394001747 Walker B; other site 380394001748 D-loop; other site 380394001749 H-loop/switch region; other site 380394001750 NAD kinase [Coenzyme metabolism]; Region: nadF; cl01255 380394001751 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02231 380394001752 Type III pantothenate kinase; Region: Pan_kinase; cl17198 380394001753 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 380394001754 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 380394001755 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 380394001756 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 380394001757 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 380394001758 putative catalytic cysteine [active] 380394001759 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 380394001760 Major Facilitator Superfamily; Region: MFS_1; pfam07690 380394001761 putative substrate translocation pore; other site 380394001762 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 380394001763 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 380394001764 Lipopolysaccharide-assembly; Region: LptE; cl01125 380394001765 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 380394001766 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 380394001767 HIGH motif; other site 380394001768 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 380394001769 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 380394001770 active site 380394001771 KMSKS motif; other site 380394001772 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 380394001773 tRNA binding surface [nucleotide binding]; other site 380394001774 NAD(P)H:quinone oxidoreductase; Provisional; Region: PRK03767 380394001775 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 380394001776 Uncharacterized conserved protein [Function unknown]; Region: COG2353 380394001777 D-ala-D-ala dipeptidase; Region: Peptidase_M15; cl00813 380394001778 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 380394001779 N-terminal domain of Fpg (formamidopyrimidine-DNA glycosylase, MutM)_Nei (endonuclease VIII) base-excision repair DNA glycosylases; Region: FpgNei_N; cd08773 380394001780 DNA binding site [nucleotide binding] 380394001781 H2TH interface [polypeptide binding]; other site 380394001782 putative catalytic residues [active] 380394001783 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 380394001784 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 380394001785 Member of the Rhodanese Homology Domain superfamily, subgroup 1. This CD includes the putative rhodanese-related sulfurtransferases of several uncharacterized proteins; Region: RHOD_1; cd01522 380394001786 active site residue [active] 380394001787 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 380394001788 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 380394001789 glutamine synthetase; Provisional; Region: glnA; PRK09469 380394001790 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 380394001791 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 380394001792 Domain of unknown function (DUF4124); Region: DUF4124; pfam13511 380394001793 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 380394001794 protein-L-isoaspartate O-methyltransferase; Reviewed; Region: pcm; PRK00312 380394001795 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 380394001796 S-adenosylmethionine binding site [chemical binding]; other site 380394001797 RNA polymerase sigma factor RpoS; Validated; Region: PRK05657 380394001798 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 380394001799 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 380394001800 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 380394001801 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 380394001802 DNA binding residues [nucleotide binding] 380394001803 Mth938-like domain. The members of this family include: Mth938, 2P1, Xcr35, Rpa2829, and several uncharacterized sequences. Mth938 is a hypothetical protein encoded by the Methanobacterium thermoautotrophicum (Mth) genome. This protein crystallizes as a...; Region: Mth938-like; cl00182 380394001804 aminotransferase; Validated; Region: PRK08175 380394001805 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 380394001806 pyridoxal 5'-phosphate binding site [chemical binding]; other site 380394001807 homodimer interface [polypeptide binding]; other site 380394001808 catalytic residue [active] 380394001809 homoserine dehydrogenase; Provisional; Region: PRK06349 380394001810 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 380394001811 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 380394001812 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 380394001813 threonine synthase; Reviewed; Region: PRK06721 380394001814 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 380394001815 homodimer interface [polypeptide binding]; other site 380394001816 pyridoxal 5'-phosphate binding site [chemical binding]; other site 380394001817 catalytic residue [active] 380394001818 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4255 380394001819 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 380394001820 DHH family; Region: DHH; pfam01368 380394001821 Virulence-associated protein and related proteins [Function unknown]; Region: VagC; COG4456 380394001822 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 380394001823 oligomeric interface; other site 380394001824 putative active site [active] 380394001825 homodimer interface [polypeptide binding]; other site 380394001826 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 380394001827 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 380394001828 dimer interface [polypeptide binding]; other site 380394001829 putative anticodon binding site; other site 380394001830 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 380394001831 motif 1; other site 380394001832 active site 380394001833 motif 2; other site 380394001834 motif 3; other site 380394001835 lipoprotein releasing system, transmembrane protein, LolC/E family; Region: lolCE; TIGR02212 380394001836 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 380394001837 FtsX-like permease family; Region: FtsX; pfam02687 380394001838 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 380394001839 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 380394001840 Walker A/P-loop; other site 380394001841 ATP binding site [chemical binding]; other site 380394001842 Q-loop/lid; other site 380394001843 ABC transporter signature motif; other site 380394001844 Walker B; other site 380394001845 D-loop; other site 380394001846 H-loop/switch region; other site 380394001847 Uncharacterized protein conserved in bacteria (DUF2062); Region: DUF2062; pfam09835 380394001848 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 380394001849 Competence protein; Region: Competence; pfam03772 380394001850 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 380394001851 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 380394001852 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 380394001853 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: DUF374; Region: LPLAT_DUF374-like; cd07983 380394001854 putative acyl-acceptor binding pocket; other site 380394001855 Tetraacyldisaccharide-1-P 4'-kinase [Cell envelope biogenesis, outer membrane]; Region: LpxK; COG1663 380394001856 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cd01983 380394001857 Uncharacterized conserved protein [Function unknown]; Region: COG2835 380394001858 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 380394001859 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 380394001860 Ligand binding site; other site 380394001861 oligomer interface; other site 380394001862 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 380394001863 dimer interface [polypeptide binding]; other site 380394001864 substrate binding site [chemical binding]; other site 380394001865 metal binding sites [ion binding]; metal-binding site 380394001866 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 380394001867 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 380394001868 trimer interface [polypeptide binding]; other site 380394001869 putative metal binding site [ion binding]; other site 380394001870 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 380394001871 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 380394001872 catalytic tetrad [active] 380394001873 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 380394001874 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 380394001875 active site 380394001876 SnoaL-like polyketide cyclase; Region: SnoaL; pfam07366 380394001877 Uncharacterized conserved protein [Function unknown]; Region: COG3791 380394001878 SnoaL-like domain; Region: SnoaL_2; pfam12680 380394001879 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 380394001880 active site 380394001881 Domain of unknown function (DUF4160); Region: DUF4160; pfam13711 380394001882 Integrase core domain; Region: rve; pfam00665 380394001883 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 380394001884 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N2; pfam13495 380394001885 INT_SG5, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 5, N- and C-terminal domains. The CD contains mainly predicted bacterial integrase/recombinases; Region: INT_SG5; cd01190 380394001886 Int/Topo IB signature motif; other site 380394001887 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 380394001888 integron integrase; Region: integrase_gron; TIGR02249 380394001889 active site 380394001890 DNA binding site [nucleotide binding] 380394001891 Int/Topo IB signature motif; other site 380394001892 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 380394001893 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 380394001894 active site 380394001895 DNA binding site [nucleotide binding] 380394001896 Int/Topo IB signature motif; other site 380394001897 Type II secretory pathway, component ExeA (predicted ATPase) [Intracellular trafficking and secretion]; Region: ExeA; COG3267 380394001898 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 380394001899 Walker A motif; other site 380394001900 ATP binding site [chemical binding]; other site 380394001901 Walker B motif; other site 380394001902 arginine finger; other site 380394001903 Domain of unknown function (DUF4160); Region: DUF4160; pfam13711 380394001904 Protein of unknown function (DUF2442); Region: DUF2442; pfam10387 380394001905 Uncharacterized subfamily of Uracil-DNA glycosylases; Region: UDG_like_1; cd10033 380394001906 putative uracil binding site [chemical binding]; other site 380394001907 putative active site [active] 380394001908 Uncharacterized conserved protein [Function unknown]; Region: COG0397 380394001909 hypothetical protein; Validated; Region: PRK00029 380394001910 ATP-dependent Clp protease ATP-binding subunit clpA; Region: ClpA; TIGR02639 380394001911 Clp amino terminal domain; Region: Clp_N; pfam02861 380394001912 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 380394001913 Walker A motif; other site 380394001914 ATP binding site [chemical binding]; other site 380394001915 Walker B motif; other site 380394001916 arginine finger; other site 380394001917 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 380394001918 Walker A motif; other site 380394001919 ATP binding site [chemical binding]; other site 380394001920 Walker B motif; other site 380394001921 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 380394001922 Uncharacterized conserved protein [Function unknown]; Region: COG2127 380394001923 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 380394001924 DJ-1 family protein; Region: not_thiJ; TIGR01383 380394001925 Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135 380394001926 conserved cys residue [active] 380394001927 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 380394001928 C-terminal peptidase (prc); Region: prc; TIGR00225 380394001929 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 380394001930 protein binding site [polypeptide binding]; other site 380394001931 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 380394001932 Catalytic dyad [active] 380394001933 Peptidase family M23; Region: Peptidase_M23; pfam01551 380394001934 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 380394001935 phosphoglyceromutase; Provisional; Region: PRK05434 380394001936 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 380394001937 homodimer interface [polypeptide binding]; other site 380394001938 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 380394001939 active site pocket [active] 380394001940 Protein required for attachment to host cells; Region: Host_attach; pfam10116 380394001941 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 380394001942 active site residue [active] 380394001943 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 380394001944 Ribokinase-like subgroup A. Found in bacteria and archaea, this subgroup is part of the ribokinase/pfkB superfamily. Its oligomerization state is unknown at this time; Region: ribokinase_group_A; cd01942 380394001945 substrate binding site [chemical binding]; other site 380394001946 ATP binding site [chemical binding]; other site 380394001947 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 380394001948 S-adenosylmethionine synthetase; Validated; Region: PRK05250 380394001949 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 380394001950 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 380394001951 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 380394001952 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 380394001953 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 380394001954 homotetramer interface [polypeptide binding]; other site 380394001955 ligand binding site [chemical binding]; other site 380394001956 catalytic site [active] 380394001957 NAD binding site [chemical binding]; other site 380394001958 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 380394001959 FAD binding site [chemical binding]; other site 380394001960 phosphoribulokinase; Provisional; Region: PRK15453 380394001961 PAP2_like proteins, Aur1_like subfamily. Yeast Aur1p or Ipc1p is necessary for the addition of inositol phosphate to ceramide, an essential step in yeast sphingolipid synthesis, and is the target of several antifungal compounds such as aureobasidin; Region: PAP2_Aur1_like; cd03386 380394001962 active site 380394001963 Domain of unknown function (DUF814); Region: DUF814; pfam05670 380394001964 bifunctional sulfate adenylyltransferase subunit 1/adenylylsulfate kinase protein; Validated; Region: PRK05537 380394001965 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 380394001966 active site 380394001967 nucleotide binding site [chemical binding]; other site 380394001968 HIGH motif; other site 380394001969 KMSKS motif; other site 380394001970 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 380394001971 ligand-binding site [chemical binding]; other site 380394001972 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 380394001973 active site 380394001974 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 380394001975 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 380394001976 ring oligomerisation interface [polypeptide binding]; other site 380394001977 ATP/Mg binding site [chemical binding]; other site 380394001978 stacking interactions; other site 380394001979 hinge regions; other site 380394001980 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 380394001981 oligomerisation interface [polypeptide binding]; other site 380394001982 mobile loop; other site 380394001983 roof hairpin; other site 380394001984 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 380394001985 Tannase and feruloyl esterase; Region: Tannase; pfam07519 380394001986 Disulphide bond corrector protein DsbC; Region: DsbC; pfam11412 380394001987 thiol:disulfide interchange protein precursor; Provisional; Region: dipZ; PRK00293 380394001988 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 380394001989 DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953 380394001990 DsbD alpha interface [polypeptide binding]; other site 380394001991 catalytic residues [active] 380394001992 Zinc-finger domain; Region: zf-CHCC; cl01821 380394001993 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 380394001994 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 380394001995 homodimer interface [polypeptide binding]; other site 380394001996 substrate-cofactor binding pocket; other site 380394001997 catalytic residue [active] 380394001998 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Reviewed; Region: PRK11072 380394001999 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 380394002000 metal binding triad; other site 380394002001 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 380394002002 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 380394002003 metal binding triad; other site 380394002004 TIGR02099 family protein; Region: TIGR02099 380394002005 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 380394002006 nitrilase; Region: PLN02798 380394002007 Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases); Region: nit; cd07572 380394002008 putative active site [active] 380394002009 catalytic triad [active] 380394002010 dimer interface [polypeptide binding]; other site 380394002011 ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178 380394002012 ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549 380394002013 ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223 380394002014 Peroxiredoxin (PRX)-like 1 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a conserved cysteine that aligns to the first cysteine in the CXXC motif of TRX. This does not correspond to the peroxidatic...; Region: PRX_like1; cd02969 380394002015 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 380394002016 putative catalytic residue [active] 380394002017 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 380394002018 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 380394002019 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 380394002020 active site 380394002021 HIGH motif; other site 380394002022 nucleotide binding site [chemical binding]; other site 380394002023 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 380394002024 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 380394002025 active site 380394002026 KMSKS motif; other site 380394002027 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 380394002028 tRNA binding surface [nucleotide binding]; other site 380394002029 anticodon binding site; other site 380394002030 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 380394002031 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 380394002032 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 380394002033 active site 380394002034 Riboflavin kinase; Region: Flavokinase; smart00904 380394002035 Uncharacterized conserved protein (DUF2203); Region: DUF2203; cl02056 380394002036 integral membrane protein MviN; Region: mviN; TIGR01695 380394002037 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 380394002038 hypothetical protein; Provisional; Region: PRK11820 380394002039 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 380394002040 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 380394002041 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 380394002042 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 380394002043 catalytic site [active] 380394002044 G-X2-G-X-G-K; other site 380394002045 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 380394002046 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 380394002047 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 380394002048 Zn2+ binding site [ion binding]; other site 380394002049 Mg2+ binding site [ion binding]; other site 380394002050 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 380394002051 synthetase active site [active] 380394002052 NTP binding site [chemical binding]; other site 380394002053 metal binding site [ion binding]; metal-binding site 380394002054 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 380394002055 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 380394002056 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 380394002057 homotrimer interaction site [polypeptide binding]; other site 380394002058 putative active site [active] 380394002059 Domain of unknown function (DUF1858); Region: DUF1858; cl14817 380394002060 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 380394002061 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 380394002062 ssDNA binding site; other site 380394002063 generic binding surface II; other site 380394002064 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 380394002065 ATP binding site [chemical binding]; other site 380394002066 putative Mg++ binding site [ion binding]; other site 380394002067 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 380394002068 nucleotide binding region [chemical binding]; other site 380394002069 ATP-binding site [chemical binding]; other site 380394002070 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 380394002071 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 380394002072 protoporphyrinogen oxidase; Region: PLN02576 380394002073 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 380394002074 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 380394002075 Domain of unknown function DUF20; Region: UPF0118; pfam01594 380394002076 Memo (mediator of ErbB2-driven cell motility) is co-precipitated with the C terminus of ErbB2, a protein involved in cell motility; Region: MEMO_like; cd07361 380394002077 putative ligand binding pocket/active site [active] 380394002078 putative metal binding site [ion binding]; other site 380394002079 AmmeMemoRadiSam system protein A; Region: AmmeMemoSam_A; TIGR04335 380394002080 AMMECR1; Region: AMMECR1; pfam01871 380394002081 AmmeMemoRadiSam system radical SAM enzyme; Region: AmmeMemoSam_rS; TIGR04337 380394002082 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 380394002083 FeS/SAM binding site; other site 380394002084 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 380394002085 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 380394002086 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 380394002087 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 380394002088 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 380394002089 Protein of unknown function (DUF2283); Region: DUF2283; pfam10049 380394002090 Domain of unknown function (DUF4258); Region: DUF4258; pfam14076 380394002091 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880 380394002092 Domain of unknown function (DUF4338); Region: DUF4338; pfam14236 380394002093 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 380394002094 Ca2+/Na+ antiporter [Inorganic ion transport and metabolism]; Region: ECM27; COG0530 380394002095 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 380394002096 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 380394002097 helicase 45; Provisional; Region: PTZ00424 380394002098 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 380394002099 ATP binding site [chemical binding]; other site 380394002100 Mg++ binding site [ion binding]; other site 380394002101 motif III; other site 380394002102 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 380394002103 nucleotide binding region [chemical binding]; other site 380394002104 ATP-binding site [chemical binding]; other site 380394002105 RNA recognition motif in Escherichia coli cold-shock DEAD box protein A (CsdA) and similar proteins; Region: RRM_EcCsdA_like; cd12499 380394002106 putative RNA binding site [nucleotide binding]; other site 380394002107 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 380394002108 DNA-binding site [nucleotide binding]; DNA binding site 380394002109 RNA-binding motif; other site 380394002110 primosome assembly protein PriA; Validated; Region: PRK05580 380394002111 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 380394002112 ATP binding site [chemical binding]; other site 380394002113 putative Mg++ binding site [ion binding]; other site 380394002114 helicase superfamily c-terminal domain; Region: HELICc; smart00490 380394002115 4-hydroxybenzoate octaprenyltransferase; Reviewed; Region: ubiA; PRK12848 380394002116 UbiA prenyltransferase family; Region: UbiA; pfam01040 380394002117 Chorismate lyase; Region: Chor_lyase; cl01230 380394002118 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 380394002119 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325 380394002120 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 380394002121 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 380394002122 FeS/SAM binding site; other site 380394002123 TRAM domain; Region: TRAM; cl01282 380394002124 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 380394002125 PhoH-like protein; Region: PhoH; pfam02562 380394002126 metal-binding heat shock protein; Provisional; Region: PRK00016 380394002127 Putative Mg2+ and Co2+ transporter CorC [Inorganic ion transport and metabolism]; Region: CorC; COG4535 380394002128 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 380394002129 Transporter associated domain; Region: CorC_HlyC; smart01091 380394002130 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 380394002131 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 380394002132 putative active site [active] 380394002133 catalytic triad [active] 380394002134 putative dimer interface [polypeptide binding]; other site 380394002135 peptidase PmbA; Provisional; Region: PRK11040 380394002136 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 380394002137 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 380394002138 intersubunit interface [polypeptide binding]; other site 380394002139 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 380394002140 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 380394002141 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 380394002142 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 380394002143 ABC-ATPase subunit interface; other site 380394002144 dimer interface [polypeptide binding]; other site 380394002145 putative PBP binding regions; other site 380394002146 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 380394002147 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 380394002148 putative PBP binding regions; other site 380394002149 ABC-ATPase subunit interface; other site 380394002150 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 380394002151 UDP glucuronic acid epimerase, extended (e) SDRs; Region: UDP_GE_SDE_e; cd05253 380394002152 putative NAD(P) binding site [chemical binding]; other site 380394002153 active site 380394002154 putative substrate binding site [chemical binding]; other site 380394002155 Predicted glycosyl transferase [General function prediction only]; Region: COG4671 380394002156 Glycosyltransferase family 28 C-terminal domain; Region: Glyco_tran_28_C; cl17369 380394002157 This is a family of GT1 glycosyltransferases found specifically in certain bacteria. amsK in Erwinia amylovora, has been reported to be involved in the biosynthesis of amylovoran, a exopolysaccharide acting as a virulence factor; Region: GT1_amsK_like; cd03799 380394002158 putative ADP-binding pocket [chemical binding]; other site 380394002159 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 380394002160 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 380394002161 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 380394002162 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 380394002163 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 380394002164 Walker A/P-loop; other site 380394002165 ATP binding site [chemical binding]; other site 380394002166 Q-loop/lid; other site 380394002167 ABC transporter signature motif; other site 380394002168 Walker B; other site 380394002169 D-loop; other site 380394002170 H-loop/switch region; other site 380394002171 nucleotide sugar dehydrogenase; Region: NDP-sugDHase; TIGR03026 380394002172 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 380394002173 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 380394002174 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 380394002175 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 380394002176 catalytic core [active] 380394002177 Helix-turn-helix domain; Region: HTH_31; pfam13560 380394002178 non-specific DNA binding site [nucleotide binding]; other site 380394002179 salt bridge; other site 380394002180 sequence-specific DNA binding site [nucleotide binding]; other site 380394002181 Methyltransferase domain; Region: Methyltransf_31; pfam13847 380394002182 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 380394002183 S-adenosylmethionine binding site [chemical binding]; other site 380394002184 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 380394002185 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 380394002186 substrate binding site [chemical binding]; other site 380394002187 ligand binding site [chemical binding]; other site 380394002188 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 380394002189 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 380394002190 substrate binding site [chemical binding]; other site 380394002191 pyridoxamine-phosphate oxidase; Region: pdxH; TIGR00558 380394002192 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 380394002193 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 380394002194 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 380394002195 tetramer (dimer of dimers) interface [polypeptide binding]; other site 380394002196 active site 380394002197 dimer interface [polypeptide binding]; other site 380394002198 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 380394002199 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 380394002200 potential catalytic triad [active] 380394002201 conserved cys residue [active] 380394002202 cytochrome o ubiquinol oxidase subunit II; Region: CyoA; TIGR01433 380394002203 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 380394002204 COX Aromatic Rich Motif; Region: COX_ARM; pfam06481 380394002205 cytochrome o ubiquinol oxidase, subunit I; Region: CyoB; TIGR02843 380394002206 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 380394002207 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cl00211 380394002208 Subunit I/III interface [polypeptide binding]; other site 380394002209 Prokaryotic Cytochrome C oxidase subunit IV; Region: COX4_pro; cl01204 380394002210 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 380394002211 UbiA prenyltransferase family; Region: UbiA; pfam01040 380394002212 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 380394002213 Major Facilitator Superfamily; Region: MFS_1; pfam07690 380394002214 putative substrate translocation pore; other site 380394002215 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 380394002216 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 380394002217 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 380394002218 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 380394002219 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 380394002220 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 380394002221 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 380394002222 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 380394002223 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 380394002224 ATP-grasp domain; Region: ATP-grasp_4; cl17255 380394002225 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 380394002226 IMP binding site; other site 380394002227 dimer interface [polypeptide binding]; other site 380394002228 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 380394002229 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 380394002230 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 380394002231 catalytic site [active] 380394002232 subunit interface [polypeptide binding]; other site 380394002233 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 380394002234 thiS-thiF/thiG interaction site; other site 380394002235 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 380394002236 ThiS interaction site; other site 380394002237 putative active site [active] 380394002238 tetramer interface [polypeptide binding]; other site 380394002239 UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase; Region: mpl; TIGR01081 380394002240 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 380394002241 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 380394002242 aromatic acid decarboxylase; Validated; Region: PRK05920 380394002243 Flavoprotein; Region: Flavoprotein; pfam02441 380394002244 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 380394002245 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 380394002246 Walker A/P-loop; other site 380394002247 ATP binding site [chemical binding]; other site 380394002248 Q-loop/lid; other site 380394002249 ABC transporter signature motif; other site 380394002250 Walker B; other site 380394002251 D-loop; other site 380394002252 H-loop/switch region; other site 380394002253 Sulphate Transporter and Anti-Sigma factor antagonist domain found in the C-terminal region of sulphate transporters as well as in bacterial and archaeal proteins involved in the regulation of sigma factors; Region: STAS; cl00604 380394002254 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 380394002255 Permease; Region: Permease; pfam02405 380394002256 Late embryogenesis abundant protein; Region: LEA_2; pfam03168 380394002257 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 380394002258 putative catalytic site [active] 380394002259 putative phosphate binding site [ion binding]; other site 380394002260 putative metal binding site [ion binding]; other site 380394002261 molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690 380394002262 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 380394002263 ATP binding site [chemical binding]; other site 380394002264 substrate interface [chemical binding]; other site 380394002265 Hydroxyneurosporene synthase (CrtC); Region: CrtC; pfam07143 380394002266 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG4181 380394002267 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 380394002268 Walker A/P-loop; other site 380394002269 ATP binding site [chemical binding]; other site 380394002270 Q-loop/lid; other site 380394002271 ABC transporter signature motif; other site 380394002272 Walker B; other site 380394002273 D-loop; other site 380394002274 H-loop/switch region; other site 380394002275 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 380394002276 catalytic residues [active] 380394002277 transcription termination factor Rho; Provisional; Region: rho; PRK09376 380394002278 Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498 380394002279 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 380394002280 RNA binding site [nucleotide binding]; other site 380394002281 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 380394002282 multimer interface [polypeptide binding]; other site 380394002283 Walker A motif; other site 380394002284 ATP binding site [chemical binding]; other site 380394002285 Walker B motif; other site 380394002286 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 380394002287 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 380394002288 Malic enzyme, N-terminal domain; Region: malic; pfam00390 380394002289 Malic enzyme, NAD binding domain; Region: Malic_M; smart00919 380394002290 NAD(P) binding pocket [chemical binding]; other site 380394002291 Domain of unknown function DUF20; Region: UPF0118; pfam01594 380394002292 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 380394002293 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 380394002294 6-phosphogluconate dehydratase; Region: edd; TIGR01196 380394002295 LabA_like proteins; Region: LabA; cd10911 380394002296 Uncharacterized conserved protein [Function unknown]; Region: COG1432 380394002297 putative metal binding site [ion binding]; other site 380394002298 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 380394002299 RNA binding site [nucleotide binding]; other site 380394002300 N-acetylglutamate synthase; Validated; Region: PRK05279 380394002301 AAK_NAGS-ABP: N-acetylglutamate (NAG) kinase-like domain of the NAG Synthase (NAGS) of the arginine-biosynthesis pathway (ABP) found in gamma- and beta-proteobacteria and higher plant chloroplasts. Domain architecture of these NAGS consisted of an...; Region: AAK_NAGS-ABP; cd04237 380394002302 putative feedback inhibition sensing region; other site 380394002303 putative nucleotide binding site [chemical binding]; other site 380394002304 putative substrate binding site [chemical binding]; other site 380394002305 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 380394002306 Coenzyme A binding pocket [chemical binding]; other site 380394002307 BolA-like protein; Region: BolA; pfam01722 380394002308 YciI-like protein; Reviewed; Region: PRK11370 380394002309 intracellular septation protein A; Reviewed; Region: PRK00259 380394002310 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG2607 380394002311 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 380394002312 Walker A motif; other site 380394002313 ATP binding site [chemical binding]; other site 380394002314 Walker B motif; other site 380394002315 arginine finger; other site 380394002316 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 380394002317 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 380394002318 active site 380394002319 dimerization interface [polypeptide binding]; other site 380394002320 rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565 380394002321 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 380394002322 Serine acetyltransferase [Amino acid transport and metabolism]; Region: CysE; COG1045 380394002323 Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762 380394002324 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 380394002325 trimer interface [polypeptide binding]; other site 380394002326 active site 380394002327 substrate binding site [chemical binding]; other site 380394002328 CoA binding site [chemical binding]; other site 380394002329 Transcriptional regulator; Region: Rrf2; cl17282 380394002330 Rrf2 family protein; Region: rrf2_super; TIGR00738 380394002331 cysteine desulfurase; Provisional; Region: PRK14012 380394002332 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 380394002333 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 380394002334 catalytic residue [active] 380394002335 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 380394002336 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 380394002337 trimerization site [polypeptide binding]; other site 380394002338 active site 380394002339 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 380394002340 DnaJ domain; Region: DnaJ; pfam00226 380394002341 co-chaperone HscB; Provisional; Region: hscB; PRK03578 380394002342 HSCB C-terminal oligomerisation domain; Region: HSCB_C; pfam07743 380394002343 chaperone protein HscA; Provisional; Region: hscA; PRK05183 380394002344 Nucleotide-binding domain of HscA and similar proteins; Region: HscA_like_NBD; cd10236 380394002345 nucleotide binding site [chemical binding]; other site 380394002346 putative NEF/HSP70 interaction site [polypeptide binding]; other site 380394002347 SBD interface [polypeptide binding]; other site 380394002348 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 380394002349 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 380394002350 catalytic loop [active] 380394002351 iron binding site [ion binding]; other site 380394002352 FeS assembly protein IscX; Region: iscX_yfhJ; TIGR03412 380394002353 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 380394002354 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 380394002355 Ligand Binding Site [chemical binding]; other site 380394002356 hypothetical protein; Provisional; Region: PRK10279 380394002357 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 380394002358 active site 380394002359 nucleophile elbow; other site 380394002360 type I restriction enzyme EcoKI subunit R; Provisional; Region: hsdR; PRK11448 380394002361 DEAD-like helicases superfamily; Region: DEXDc; smart00487 380394002362 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 380394002363 ATP binding site [chemical binding]; other site 380394002364 putative Mg++ binding site [ion binding]; other site 380394002365 EcoEI R protein C-terminal; Region: EcoEI_R_C; pfam08463 380394002366 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 380394002367 HsdM N-terminal domain; Region: HsdM_N; pfam12161 380394002368 Methyltransferase domain; Region: Methyltransf_26; pfam13659 380394002369 Virulence protein RhuM family; Region: Virulence_RhuM; pfam13310 380394002370 Fic/DOC family; Region: Fic; pfam02661 380394002371 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 380394002372 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 380394002373 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 380394002374 SIR2-like domain; Region: SIR2_2; pfam13289 380394002375 Integrase core domain; Region: rve_3; pfam13683 380394002376 FdhD/NarQ family; Region: FdhD-NarQ; pfam02634 380394002377 alkylmercury lyase; Provisional; Region: PRK13239 380394002378 oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701 380394002379 The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767 380394002380 putative molybdopterin cofactor binding site [chemical binding]; other site 380394002381 The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787 380394002382 putative molybdopterin cofactor binding site; other site 380394002383 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 380394002384 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 380394002385 Walker A motif; other site 380394002386 ATP binding site [chemical binding]; other site 380394002387 Walker B motif; other site 380394002388 arginine finger; other site 380394002389 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 380394002390 glutathione-dependent formaldehyde-activating enzyme; Provisional; Region: PRK05417 380394002391 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 380394002392 class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300 380394002393 substrate binding site [chemical binding]; other site 380394002394 catalytic Zn binding site [ion binding]; other site 380394002395 NAD binding site [chemical binding]; other site 380394002396 structural Zn binding site [ion binding]; other site 380394002397 dimer interface [polypeptide binding]; other site 380394002398 S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821 380394002399 S-formylglutathione hydrolase; Region: PLN02442 380394002400 transcriptional regulator CysB-like protein; Reviewed; Region: PRK12684 380394002401 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 380394002402 The C-terminal substrate domain of LysR-type transcriptional regulators CysB-like contains type 2 periplasmic binding fold; Region: PBP2_CysB_like; cd08413 380394002403 substrate binding site [chemical binding]; other site 380394002404 dimerization interface [polypeptide binding]; other site 380394002405 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 380394002406 active site 380394002407 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 380394002408 phosphorylation site [posttranslational modification] 380394002409 intermolecular recognition site; other site 380394002410 dimerization interface [polypeptide binding]; other site 380394002411 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 380394002412 Walker A motif; other site 380394002413 ATP binding site [chemical binding]; other site 380394002414 Walker B motif; other site 380394002415 arginine finger; other site 380394002416 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 380394002417 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 380394002418 Ni,Fe-hydrogenase I small subunit [Energy production and conversion]; Region: HyaA; COG1740 380394002419 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 380394002420 Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374 380394002421 Nickel-dependent hydrogenase; Region: NiFeSe_Hases; pfam00374 380394002422 inositol phosphate phosphatase SopB; Provisional; Region: PRK15378 380394002423 Hydrogenase specific C-terminal endopeptidases, also called Hydrogen Maturation Proteases (H2MP). These enzymes belong to the peptidase family M52. Maturation of [FeNi] hydrogenases includes formation of the nickel metallocenter, proteolytic processing...; Region: H2MP; cl00477 380394002424 nickel binding site [ion binding]; other site 380394002425 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 380394002426 TPR motif; other site 380394002427 binding surface 380394002428 Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694 380394002429 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 380394002430 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 380394002431 iron-sulfur cluster [ion binding]; other site 380394002432 [2Fe-2S] cluster binding site [ion binding]; other site 380394002433 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068 380394002434 Acylphosphatase; Region: Acylphosphatase; pfam00708 380394002435 HypF finger; Region: zf-HYPF; pfam07503 380394002436 HypF finger; Region: zf-HYPF; pfam07503 380394002437 Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300 380394002438 HupF/HypC family; Region: HupF_HypC; pfam01455 380394002439 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 380394002440 dimer interface [polypeptide binding]; other site 380394002441 active site 380394002442 hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062 380394002443 hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075 380394002444 HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis. HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197 380394002445 dimerization interface [polypeptide binding]; other site 380394002446 hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124 380394002447 ATP binding site [chemical binding]; other site 380394002448 Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) [General function prediction only]; Region: HybF; COG0375 380394002449 Hydrogenase expression/synthesis hypA family; Region: HypA; pfam01155 380394002450 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 380394002451 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 380394002452 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 380394002453 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 380394002454 superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280 380394002455 heme-binding site [chemical binding]; other site 380394002456 threonine dehydratase; Reviewed; Region: PRK09224 380394002457 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 380394002458 tetramer interface [polypeptide binding]; other site 380394002459 pyridoxal 5'-phosphate binding site [chemical binding]; other site 380394002460 catalytic residue [active] 380394002461 First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906 380394002462 putative Ile/Val binding site [chemical binding]; other site 380394002463 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 380394002464 putative Ile/Val binding site [chemical binding]; other site 380394002465 N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; cl17549 380394002466 Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; Region: COG0429 380394002467 Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; cl17496 380394002468 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 380394002469 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 380394002470 putative acyl-acceptor binding pocket; other site 380394002471 methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252 380394002472 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 380394002473 substrate binding site [chemical binding]; other site 380394002474 active site 380394002475 glutamate synthase small subunit family protein, proteobacterial; Region: gltD_gamma_fam; TIGR01318 380394002476 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 380394002477 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 380394002478 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 380394002479 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 380394002480 active site 380394002481 dimer interface [polypeptide binding]; other site 380394002482 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 380394002483 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 380394002484 active site 380394002485 FMN binding site [chemical binding]; other site 380394002486 substrate binding site [chemical binding]; other site 380394002487 3Fe-4S cluster binding site [ion binding]; other site 380394002488 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 380394002489 domain interface; other site 380394002490 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01286 380394002491 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 380394002492 Zn2+ binding site [ion binding]; other site 380394002493 Mg2+ binding site [ion binding]; other site 380394002494 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 380394002495 Thymidylate synthase complementing protein; Region: Thy1; pfam02511 380394002496 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 380394002497 active site 380394002498 dimer interface [polypeptide binding]; other site 380394002499 metal binding site [ion binding]; metal-binding site 380394002500 shikimate kinase; Reviewed; Region: aroK; PRK00131 380394002501 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 380394002502 ADP binding site [chemical binding]; other site 380394002503 magnesium binding site [ion binding]; other site 380394002504 putative shikimate binding site; other site 380394002505 type IV pilus secretin (or competence protein) PilQ; Region: IV_pilus_PilQ; TIGR02515 380394002506 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 380394002507 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 380394002508 Tfp pilus assembly protein PilP [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilP; COG3168 380394002509 Pilus assembly protein, PilP; Region: PilP; pfam04351 380394002510 Pilus assembly protein, PilO; Region: PilO; pfam04350 380394002511 Tfp pilus assembly protein PilN [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilN; COG3166 380394002512 Fimbrial assembly protein (PilN); Region: PilN; pfam05137 380394002513 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 380394002514 nucleoside/Zn binding site; other site 380394002515 dimer interface [polypeptide binding]; other site 380394002516 catalytic motif [active] 380394002517 Uncharacterized protein family UPF0047; Region: UPF0047; pfam01894 380394002518 DNA-binding domain of DNA mismatch repair MUTS family; Region: MUTSd; smart00533 380394002519 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 380394002520 Walker A/P-loop; other site 380394002521 ATP binding site [chemical binding]; other site 380394002522 Q-loop/lid; other site 380394002523 ABC transporter signature motif; other site 380394002524 Walker B; other site 380394002525 D-loop; other site 380394002526 H-loop/switch region; other site 380394002527 acetolactate synthase 3 catalytic subunit; Validated; Region: PRK06965 380394002528 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 380394002529 PYR/PP interface [polypeptide binding]; other site 380394002530 dimer interface [polypeptide binding]; other site 380394002531 TPP binding site [chemical binding]; other site 380394002532 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 380394002533 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 380394002534 TPP-binding site [chemical binding]; other site 380394002535 dimer interface [polypeptide binding]; other site 380394002536 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 380394002537 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 380394002538 putative valine binding site [chemical binding]; other site 380394002539 dimer interface [polypeptide binding]; other site 380394002540 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 380394002541 ketol-acid reductoisomerase; Provisional; Region: PRK05479 380394002542 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 380394002543 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 380394002544 phosphatidylserine decarboxylase; Provisional; Region: PRK05305 380394002545 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 380394002546 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 380394002547 pyruvate kinase; Provisional; Region: PRK14725 380394002548 active site 380394002549 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 380394002550 Ligand Binding Site [chemical binding]; other site 380394002551 7-cyano-7-deazaguanine reductase; Provisional; Region: PRK13258 380394002552 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 380394002553 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 380394002554 Walker A/P-loop; other site 380394002555 ATP binding site [chemical binding]; other site 380394002556 Q-loop/lid; other site 380394002557 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; cl05797 380394002558 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 380394002559 ABC transporter signature motif; other site 380394002560 Walker B; other site 380394002561 D-loop; other site 380394002562 H-loop/switch region; other site 380394002563 superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280 380394002564 heme-binding site [chemical binding]; other site 380394002565 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 380394002566 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 380394002567 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 380394002568 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 380394002569 nucleotide binding pocket [chemical binding]; other site 380394002570 K-X-D-G motif; other site 380394002571 catalytic site [active] 380394002572 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 380394002573 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 380394002574 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 380394002575 Dimer interface [polypeptide binding]; other site 380394002576 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 380394002577 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 380394002578 gamma subunit interface [polypeptide binding]; other site 380394002579 epsilon subunit interface [polypeptide binding]; other site 380394002580 LBP interface [polypeptide binding]; other site 380394002581 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 380394002582 S-adenosylmethionine binding site [chemical binding]; other site 380394002583 Protein of unknown function DUF45; Region: DUF45; pfam01863 380394002584 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 380394002585 Transcriptional regulator [Transcription]; Region: LysR; COG0583 380394002586 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 380394002587 dimerization interface [polypeptide binding]; other site 380394002588 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 380394002589 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 380394002590 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 380394002591 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 380394002592 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 380394002593 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 380394002594 TonB family C-terminal domain; Region: tonB_Cterm; TIGR01352 380394002595 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 380394002596 guanine deaminase; Provisional; Region: PRK09228 380394002597 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 380394002598 active site 380394002599 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 380394002600 Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320 380394002601 active site 380394002602 purine riboside binding site [chemical binding]; other site 380394002603 Purine nucleoside permease (NUP); Region: NUP; cl17832 380394002604 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 380394002605 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 380394002606 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 380394002607 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 380394002608 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 380394002609 xanthine dehydrogenase subunit XdhB; Provisional; Region: PRK09971 380394002610 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450 380394002611 Ureidoglycolate hydrolase; Region: Ureidogly_hydro; cl01250 380394002612 Amidohydrolase ring-opening protein (Amido_AtzD_TrzD); Region: Amido_AtzD_TrzD; cl17559 380394002613 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 380394002614 xanthine dehydrogenase accessory protein XdhC; Region: xanthine_xdhC; TIGR02964 380394002615 XdhC Rossmann domain; Region: XdhC_C; pfam13478 380394002616 Protein of unknown function (DUF4089); Region: DUF4089; pfam13318 380394002617 amidase; Provisional; Region: PRK09201 380394002618 Amidase; Region: Amidase; cl11426 380394002619 Protein of unknown function (DUF3225); Region: DUF3225; pfam11533 380394002620 MobA-like NTP transferase domain; Region: NTP_transf_3; pfam12804 380394002621 active site 380394002622 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 380394002623 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 380394002624 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 380394002625 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 380394002626 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 380394002627 NodB motif; other site 380394002628 active site 380394002629 catalytic site [active] 380394002630 metal binding site [ion binding]; metal-binding site 380394002631 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 380394002632 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 380394002633 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_5; cd06153 380394002634 homotrimer interaction site [polypeptide binding]; other site 380394002635 putative active site [active] 380394002636 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 380394002637 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 380394002638 putative acyl-acceptor binding pocket; other site 380394002639 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 380394002640 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 380394002641 Ligand binding site; other site 380394002642 Putative Catalytic site; other site 380394002643 DXD motif; other site 380394002644 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 380394002645 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 380394002646 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 380394002647 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 380394002648 NAD(P) binding site [chemical binding]; other site 380394002649 active site 380394002650 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 380394002651 active site 2 [active] 380394002652 active site 1 [active] 380394002653 Beta-ketoacyl synthase, N-terminal domain; Region: Ketoacyl-synt_2; pfam13723 380394002654 3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK09185 380394002655 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 380394002656 dimer interface [polypeptide binding]; other site 380394002657 active site 380394002658 Phosphopantetheine attachment site; Region: PP-binding; cl09936 380394002659 Predicted exporter [General function prediction only]; Region: COG4258 380394002660 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 380394002661 putative acyl-acceptor binding pocket; other site 380394002662 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880 380394002663 Domain of unknown function (DUF4338); Region: DUF4338; pfam14236 380394002664 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 380394002665 Predicted membrane protein [Function unknown]; Region: COG4648 380394002666 GH3 auxin-responsive promoter; Region: GH3; pfam03321 380394002667 Penicillin amidase; Region: Penicil_amidase; pfam01804 380394002668 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 380394002669 Penicillin G acylase (PGA) belongs to a family of beta-lactam acylases that includes cephalosporin acylase (CA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_PGA_like; cd03747 380394002670 active site 380394002671 FAD binding domain in molybdopterin dehydrogenase; Region: FAD_binding_5; pfam00941 380394002672 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 380394002673 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 380394002674 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 380394002675 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 380394002676 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 380394002677 catalytic loop [active] 380394002678 iron binding site [ion binding]; other site 380394002679 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 380394002680 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 380394002681 Major Facilitator Superfamily; Region: MFS_1; pfam07690 380394002682 putative substrate translocation pore; other site 380394002683 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 380394002684 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 380394002685 Cl- selectivity filter; other site 380394002686 Cl- binding residues [ion binding]; other site 380394002687 pore gating glutamate residue; other site 380394002688 dimer interface [polypeptide binding]; other site 380394002689 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 380394002690 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 380394002691 Cl- selectivity filter; other site 380394002692 Cl- binding residues [ion binding]; other site 380394002693 pore gating glutamate residue; other site 380394002694 dimer interface [polypeptide binding]; other site 380394002695 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 380394002696 Transcriptional regulator [Transcription]; Region: LysR; COG0583 380394002697 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 380394002698 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 380394002699 dimerization interface [polypeptide binding]; other site 380394002700 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 380394002701 plasma-membrane proton-efflux P-type ATPase; Region: ATPase-IIIA_H; TIGR01647 380394002702 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 380394002703 Soluble P-type ATPase [General function prediction only]; Region: COG4087 380394002704 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 380394002705 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 380394002706 active site 380394002707 metal binding site [ion binding]; metal-binding site 380394002708 HsdM N-terminal domain; Region: HsdM_N; pfam12161 380394002709 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 380394002710 Domain of unknown function (DUF4062); Region: DUF4062; pfam13271 380394002711 Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865 380394002712 ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749 380394002713 Virulence protein [General function prediction only]; Region: COG3943 380394002714 Virulence protein RhuM family; Region: Virulence_RhuM; pfam13310 380394002715 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 380394002716 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 380394002717 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 380394002718 AAA domain; Region: AAA_21; pfam13304 380394002719 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 380394002720 ABC transporter signature motif; other site 380394002721 Walker B; other site 380394002722 D-loop; other site 380394002723 H-loop/switch region; other site 380394002724 type I site-specific deoxyribonuclease, HsdR family; Region: hsdR; TIGR00348 380394002725 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 380394002726 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 380394002727 ATP binding site [chemical binding]; other site 380394002728 putative Mg++ binding site [ion binding]; other site 380394002729 Protein of unknown function DUF45; Region: DUF45; cl00636 380394002730 excinuclease ABC subunit B; Provisional; Region: PRK05298 380394002731 Myosin and Kinesin motor domain. These ATPases belong to the P-loop NTPase family and provide the driving force in myosin and kinesin mediated processes; Region: Motor_domain; cl00286 380394002732 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 380394002733 ATP-binding site [chemical binding]; other site 380394002734 ATP binding site [chemical binding]; other site 380394002735 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 380394002736 nucleotide binding region [chemical binding]; other site 380394002737 ATP-binding site [chemical binding]; other site 380394002738 Ultra-violet resistance protein B; Region: UvrB; pfam12344 380394002739 UvrB/uvrC motif; Region: UVR; pfam02151 380394002740 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 380394002741 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 380394002742 putative NAD(P) binding site [chemical binding]; other site 380394002743 putative substrate binding site [chemical binding]; other site 380394002744 catalytic Zn binding site [ion binding]; other site 380394002745 structural Zn binding site [ion binding]; other site 380394002746 dimer interface [polypeptide binding]; other site 380394002747 CTP synthetase; Validated; Region: pyrG; PRK05380 380394002748 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 380394002749 Catalytic site [active] 380394002750 active site 380394002751 UTP binding site [chemical binding]; other site 380394002752 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 380394002753 active site 380394002754 putative oxyanion hole; other site 380394002755 catalytic triad [active] 380394002756 2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198 380394002757 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 380394002758 enolase; Provisional; Region: eno; PRK00077 380394002759 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 380394002760 dimer interface [polypeptide binding]; other site 380394002761 metal binding site [ion binding]; metal-binding site 380394002762 substrate binding pocket [chemical binding]; other site 380394002763 Septum formation initiator; Region: DivIC; cl17659 380394002764 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 380394002765 translation elongation factor P; Region: efp; TIGR00038 380394002766 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 380394002767 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 380394002768 RNA binding site [nucleotide binding]; other site 380394002769 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 380394002770 RNA binding site [nucleotide binding]; other site 380394002771 Protein of unknown function (DUF971); Region: DUF971; pfam06155 380394002772 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 380394002773 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 380394002774 GIY-YIG motif/motif A; other site 380394002775 active site 380394002776 catalytic site [active] 380394002777 putative DNA binding site [nucleotide binding]; other site 380394002778 metal binding site [ion binding]; metal-binding site 380394002779 UvrB/uvrC motif; Region: UVR; pfam02151 380394002780 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 380394002781 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 380394002782 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 380394002783 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 380394002784 ligand binding site [chemical binding]; other site 380394002785 flexible hinge region; other site 380394002786 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 380394002787 putative switch regulator; other site 380394002788 non-specific DNA interactions [nucleotide binding]; other site 380394002789 DNA binding site [nucleotide binding] 380394002790 sequence specific DNA binding site [nucleotide binding]; other site 380394002791 putative cAMP binding site [chemical binding]; other site 380394002792 Protein of unknown function, DUF488; Region: DUF488; cl01246 380394002793 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 380394002794 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 380394002795 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 380394002796 CDP-6-deoxy-delta-3,4-glucoseen reductase; Validated; Region: PRK07609 380394002797 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 380394002798 catalytic loop [active] 380394002799 iron binding site [ion binding]; other site 380394002800 The oxygenase reductase FAD/NADH binding domain acts as part of the multi-component bacterial oxygenases which oxidize hydrocarbons using oxygen as the oxidant. Electron transfer is from NADH via FAD (in the oxygenase reductase) and an [2FE-2S]...; Region: O2ase_reductase_like; cd06187 380394002801 FAD binding pocket [chemical binding]; other site 380394002802 FAD binding motif [chemical binding]; other site 380394002803 phosphate binding motif [ion binding]; other site 380394002804 beta-alpha-beta structure motif; other site 380394002805 NAD binding pocket [chemical binding]; other site 380394002806 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 380394002807 heme-binding site [chemical binding]; other site 380394002808 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 380394002809 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 380394002810 HlyD family secretion protein; Region: HlyD_3; pfam13437 380394002811 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 380394002812 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 380394002813 putative substrate translocation pore; other site 380394002814 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 380394002815 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 380394002816 Transcriptional regulator [Transcription]; Region: LysR; COG0583 380394002817 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 380394002818 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 380394002819 dimerization interface [polypeptide binding]; other site 380394002820 Fumarylacetoacetate (FAA) hydrolase family protein [General function prediction only]; Region: COG3970 380394002821 Dna-J like membrane chaperone protein; Provisional; Region: djlA; PRK09430 380394002822 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 380394002823 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 380394002824 Plasmid encoded toxin Txe; Region: Plasmid_Txe; cl17389 380394002825 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 380394002826 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 380394002827 putative dimer interface [polypeptide binding]; other site 380394002828 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 380394002829 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 380394002830 Walker A motif; other site 380394002831 ATP binding site [chemical binding]; other site 380394002832 Walker B motif; other site 380394002833 arginine finger; other site 380394002834 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 380394002835 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 380394002836 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 380394002837 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 380394002838 Coenzyme A binding pocket [chemical binding]; other site 380394002839 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 380394002840 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 380394002841 substrate binding pocket [chemical binding]; other site 380394002842 Transcriptional activator [Transcription]; Region: ChrR; COG3806 380394002843 ChrR Cupin-like domain; Region: Cupin_7; pfam12973 380394002844 ChrR Cupin-like domain; Region: Cupin_7; pfam12973 380394002845 Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231 380394002846 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 380394002847 Uncharacterized conserved protein [Function unknown]; Region: COG0393 380394002848 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153 380394002849 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 380394002850 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 380394002851 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 380394002852 putative RNA binding site [nucleotide binding]; other site 380394002853 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 380394002854 S-adenosylmethionine binding site [chemical binding]; other site 380394002855 Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]; Region: COG0182 380394002856 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 380394002857 DNA gyrase subunit A; Validated; Region: PRK05560 380394002858 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 380394002859 CAP-like domain; other site 380394002860 active site 380394002861 primary dimer interface [polypeptide binding]; other site 380394002862 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 380394002863 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 380394002864 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 380394002865 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 380394002866 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 380394002867 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 380394002868 Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT). PSAT is active as...; Region: PSAT_like; cd00611 380394002869 homodimer interface [polypeptide binding]; other site 380394002870 substrate-cofactor binding pocket; other site 380394002871 pyridoxal 5'-phosphate binding site [chemical binding]; other site 380394002872 catalytic residue [active] 380394002873 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 380394002874 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 380394002875 ligand binding site [chemical binding]; other site 380394002876 NAD binding site [chemical binding]; other site 380394002877 dimerization interface [polypeptide binding]; other site 380394002878 catalytic site [active] 380394002879 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 380394002880 putative L-serine binding site [chemical binding]; other site 380394002881 Chorismate mutase type II; Region: CM_2; cl00693 380394002882 Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077 380394002883 Prephenate dehydratase; Region: PDT; pfam00800 380394002884 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 380394002885 putative L-Phe binding site [chemical binding]; other site 380394002886 histidinol-phosphate aminotransferase; Validated; Region: PRK02731 380394002887 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 380394002888 pyridoxal 5'-phosphate binding site [chemical binding]; other site 380394002889 homodimer interface [polypeptide binding]; other site 380394002890 catalytic residue [active] 380394002891 3-deoxy-7-phosphoheptulonate synthase; Reviewed; Region: PRK08673 380394002892 phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361 380394002893 Prephenate dehydrogenase [Amino acid transport and metabolism]; Region: TyrA; COG0287 380394002894 prephenate dehydrogenase; Validated; Region: PRK08507 380394002895 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 380394002896 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 380394002897 hinge; other site 380394002898 active site 380394002899 cytidylate kinase; Provisional; Region: cmk; PRK00023 380394002900 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 380394002901 CMP-binding site; other site 380394002902 The sites determining sugar specificity; other site 380394002903 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 380394002904 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 380394002905 RNA binding site [nucleotide binding]; other site 380394002906 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 380394002907 RNA binding site [nucleotide binding]; other site 380394002908 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 380394002909 RNA binding site [nucleotide binding]; other site 380394002910 S1_RPS1_repeat_ec4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec4; cd05689 380394002911 RNA binding site [nucleotide binding]; other site 380394002912 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 380394002913 RNA binding site [nucleotide binding]; other site 380394002914 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 380394002915 RNA binding site [nucleotide binding]; other site 380394002916 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 380394002917 IHF - DNA interface [nucleotide binding]; other site 380394002918 IHF dimer interface [polypeptide binding]; other site 380394002919 tetratricopeptide repeat protein; Provisional; Region: PRK11788 380394002920 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 380394002921 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 380394002922 active site 380394002923 dimer interface [polypeptide binding]; other site 380394002924 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 380394002925 active site 380394002926 trigger factor; Provisional; Region: tig; PRK01490 380394002927 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 380394002928 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 380394002929 Clp protease; Region: CLP_protease; pfam00574 380394002930 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 380394002931 oligomer interface [polypeptide binding]; other site 380394002932 active site residues [active] 380394002933 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 380394002934 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 380394002935 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 380394002936 Walker A motif; other site 380394002937 ATP binding site [chemical binding]; other site 380394002938 Walker B motif; other site 380394002939 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 380394002940 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 380394002941 Found in ATP-dependent protease La (LON); Region: LON; smart00464 380394002942 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 380394002943 Walker A motif; other site 380394002944 ATP binding site [chemical binding]; other site 380394002945 Walker B motif; other site 380394002946 arginine finger; other site 380394002947 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 380394002948 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 380394002949 IHF dimer interface [polypeptide binding]; other site 380394002950 IHF - DNA interface [nucleotide binding]; other site 380394002951 SurA N-terminal domain; Region: SurA_N_3; pfam13624 380394002952 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 380394002953 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 380394002954 active site 380394002955 Domain of unknown function (DUF4337); Region: DUF4337; pfam14235 380394002956 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 380394002957 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 380394002958 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 380394002959 putative substrate translocation pore; other site 380394002960 putative lysogenization regulator; Reviewed; Region: PRK00218 380394002961 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 380394002962 UTP:GlnB (protein PII) uridylyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: GlnD; COG2844 380394002963 metal binding triad; other site 380394002964 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 380394002965 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 380394002966 Zn2+ binding site [ion binding]; other site 380394002967 Mg2+ binding site [ion binding]; other site 380394002968 ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900 380394002969 C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899 380394002970 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 380394002971 active site 380394002972 putative DNA-binding transcriptional regulator; Reviewed; Region: PRK00347 380394002973 glutamyl-queuosine tRNA(Asp) synthetase; Region: queuosine_YadB; TIGR03838 380394002974 active site 380394002975 nucleotide binding site [chemical binding]; other site 380394002976 HIGH motif; other site 380394002977 KMSKS motif; other site 380394002978 thiamine monophosphate kinase; Provisional; Region: PRK05731 380394002979 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 380394002980 ATP binding site [chemical binding]; other site 380394002981 dimerization interface [polypeptide binding]; other site 380394002982 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 380394002983 tetramer interfaces [polypeptide binding]; other site 380394002984 binuclear metal-binding site [ion binding]; other site 380394002985 Uncharacterized protein (competence- and mitomycin-induced) [General function prediction only]; Region: CinA; COG1546 380394002986 recombinase A; Provisional; Region: recA; PRK09354 380394002987 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 380394002988 hexamer interface [polypeptide binding]; other site 380394002989 Walker A motif; other site 380394002990 ATP binding site [chemical binding]; other site 380394002991 Walker B motif; other site 380394002992 RecX family; Region: RecX; pfam02631 380394002993 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 380394002994 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 380394002995 motif 1; other site 380394002996 active site 380394002997 motif 2; other site 380394002998 motif 3; other site 380394002999 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 380394003000 DHHA1 domain; Region: DHHA1; pfam02272 380394003001 Hydrogenase specific C-terminal endopeptidases, also called Hydrogen Maturation Proteases (H2MP). These enzymes belong to the peptidase family M52. Maturation of [FeNi] hydrogenases includes formation of the nickel metallocenter, proteolytic processing...; Region: H2MP; cd00518 380394003002 nickel binding site [ion binding]; other site 380394003003 Coenzyme F420-reducing hydrogenase, alpha subunit [Energy production and conversion]; Region: FrhA; COG3259 380394003004 Ni,Fe-hydrogenase III large subunit [Energy production and conversion]; Region: HycE; COG3261 380394003005 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 380394003006 anaerobic sulfite reductase subunit B; Provisional; Region: PRK08221 380394003007 Anaerobic sulfite reductase contains an FAD and NADPH binding module with structural similarity to ferredoxin reductase and sequence similarity to dihydroorotate dehydrogenases. Clostridium pasteurianum inducible dissimilatory type sulfite reductase is...; Region: sulfite_reductase_like; cd06221 380394003008 FAD binding pocket [chemical binding]; other site 380394003009 FAD binding motif [chemical binding]; other site 380394003010 phosphate binding motif [ion binding]; other site 380394003011 beta-alpha-beta structure motif; other site 380394003012 NAD binding pocket [chemical binding]; other site 380394003013 Iron coordination center [ion binding]; other site 380394003014 4Fe-4S dicluster domain; Region: Fer4_18; pfam13746 380394003015 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 380394003016 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 380394003017 N-acetyl-D-glucosamine binding site [chemical binding]; other site 380394003018 catalytic residue [active] 380394003019 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 380394003020 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 380394003021 ATP binding site [chemical binding]; other site 380394003022 putative Mg++ binding site [ion binding]; other site 380394003023 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 380394003024 nucleotide binding region [chemical binding]; other site 380394003025 ATP-binding site [chemical binding]; other site 380394003026 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 380394003027 ManB is a bacterial phosphomannomutase (PMM) that catalyzes the conversion of mannose 6-phosphate to mannose-1-phosphate in the second of three steps in the GDP-mannose pathway, in which GDP-D-mannose is synthesized from fructose-6-phosphate. In...; Region: ManB; cd03088 380394003028 active site 380394003029 substrate binding site [chemical binding]; other site 380394003030 metal binding site [ion binding]; metal-binding site 380394003031 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 380394003032 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 380394003033 Walker A/P-loop; other site 380394003034 ATP binding site [chemical binding]; other site 380394003035 Q-loop/lid; other site 380394003036 ABC transporter signature motif; other site 380394003037 Walker B; other site 380394003038 D-loop; other site 380394003039 H-loop/switch region; other site 380394003040 ABC transporter; Region: ABC_tran_2; pfam12848 380394003041 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 380394003042 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 380394003043 ThiC-associated domain; Region: ThiC-associated; pfam13667 380394003044 Thiamine biosynthesis protein ThiC [Coenzyme metabolism]; Region: ThiC; COG0422 380394003045 Predicted integral membrane protein [Function unknown]; Region: COG5615 380394003046 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 380394003047 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 380394003048 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 380394003049 Coniferyl aldehyde dehydrogenase-like; Region: ALDH_CALDH_CalB; cd07133 380394003050 NAD(P) binding site [chemical binding]; other site 380394003051 catalytic residues [active] 380394003052 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 380394003053 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 380394003054 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562 380394003055 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 380394003056 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 380394003057 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 380394003058 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 380394003059 Walker A motif; other site 380394003060 ATP binding site [chemical binding]; other site 380394003061 Walker B motif; other site 380394003062 arginine finger; other site 380394003063 HTH domain; Region: HTH_11; pfam08279 380394003064 Phospholipase/Carboxylesterase; Region: Abhydrolase_2; pfam02230 380394003065 putative hydrolase; Provisional; Region: PRK11460 380394003066 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 380394003067 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 380394003068 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 380394003069 glucan biosynthesis protein G; Provisional; Region: mdoG; PRK13274 380394003070 glucan biosynthesis protein D; Provisional; Region: mdoD; PRK13273 380394003071 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 380394003072 Glucan_BSP_ModH catalyzes the elongation of beta-1,2 polyglucose chains of glucan; Region: Glucan_BSP_ModH; cd04191 380394003073 Ligand binding site; other site 380394003074 DXD motif; other site 380394003075 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, subunit 9, 39 kDa, (NDUFA9) -like, atypical (a) SDRs; Region: NDUFA9_like_SDR_a; cd05271 380394003076 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 380394003077 putative NAD(P) binding site [chemical binding]; other site 380394003078 active site 380394003079 V4R domain; Region: V4R; cl15268 380394003080 von Willebrand factor type A domain; Region: VWA_2; pfam13519 380394003081 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 380394003082 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 380394003083 type IV pilus modification protein PilV; Region: type_IV_pilV; TIGR02523 380394003084 Tfp pilus assembly protein FimT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimT; COG4970 380394003085 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 380394003086 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 380394003087 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 380394003088 Peptidase family S49 N-terminal; Region: Peptidase_S49_N; pfam08496 380394003089 putative inner membrane peptidase; Provisional; Region: PRK11778 380394003090 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 380394003091 tandem repeat interface [polypeptide binding]; other site 380394003092 oligomer interface [polypeptide binding]; other site 380394003093 active site residues [active] 380394003094 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 380394003095 MoaE interaction surface [polypeptide binding]; other site 380394003096 MoeB interaction surface [polypeptide binding]; other site 380394003097 thiocarboxylated glycine; other site 380394003098 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 380394003099 MoaE homodimer interface [polypeptide binding]; other site 380394003100 MoaD interaction [polypeptide binding]; other site 380394003101 active site residues [active] 380394003102 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 380394003103 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 380394003104 Roadblock/LC7 domain; Region: Robl_LC7; pfam03259 380394003105 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 380394003106 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 380394003107 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 380394003108 lipoyl attachment site [posttranslational modification]; other site 380394003109 glycine dehydrogenase subunit 1; Validated; Region: PRK00451 380394003110 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 380394003111 catalytic residue [active] 380394003112 glycine dehydrogenase subunit 2; Validated; Region: PRK04366 380394003113 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 380394003114 catalytic residue [active] 380394003115 lipid A export permease/ATP-binding protein MsbA; Region: MsbA_lipidA; TIGR02203 380394003116 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 380394003117 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 380394003118 Walker A/P-loop; other site 380394003119 ATP binding site [chemical binding]; other site 380394003120 Q-loop/lid; other site 380394003121 ABC transporter signature motif; other site 380394003122 Walker B; other site 380394003123 D-loop; other site 380394003124 H-loop/switch region; other site 380394003125 Ferredoxin [Energy production and conversion]; Region: COG1146 380394003126 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 380394003127 Domain of unknown function (DUF3470); Region: DUF3470; pfam11953 380394003128 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 380394003129 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 380394003130 dimer interface [polypeptide binding]; other site 380394003131 decamer (pentamer of dimers) interface [polypeptide binding]; other site 380394003132 catalytic triad [active] 380394003133 peroxidatic and resolving cysteines [active] 380394003134 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 380394003135 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 380394003136 active site 380394003137 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 380394003138 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465 380394003139 23S rRNA (guanosine-2'-O-)-methyltransferase; Provisional; Region: PRK11181 380394003140 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 380394003141 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 380394003142 active site 380394003143 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 380394003144 putative hydrolase; Provisional; Region: PRK02113 380394003145 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4398 380394003146 FIST N domain; Region: FIST; pfam08495 380394003147 FIST C domain; Region: FIST_C; pfam10442 380394003148 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 380394003149 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 380394003150 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 380394003151 Walker A/P-loop; other site 380394003152 ATP binding site [chemical binding]; other site 380394003153 Q-loop/lid; other site 380394003154 ABC transporter signature motif; other site 380394003155 Walker B; other site 380394003156 D-loop; other site 380394003157 H-loop/switch region; other site 380394003158 cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11160 380394003159 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 380394003160 Walker A/P-loop; other site 380394003161 ATP binding site [chemical binding]; other site 380394003162 Q-loop/lid; other site 380394003163 ABC transporter signature motif; other site 380394003164 Walker B; other site 380394003165 D-loop; other site 380394003166 H-loop/switch region; other site 380394003167 Aminomethyltransferase folate-binding domain; Region: GCV_T; pfam01571 380394003168 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 380394003169 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 380394003170 L-aspartate oxidase; Provisional; Region: PRK09077 380394003171 L-aspartate oxidase; Provisional; Region: PRK06175 380394003172 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 380394003173 RNA polymerase sigma factor RpoE; Region: RpoE_Sigma70; TIGR02939 380394003174 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 380394003175 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 380394003176 DNA binding residues [nucleotide binding] 380394003177 Anti sigma-E protein RseA, N-terminal domain; Region: RseA_N; pfam03872 380394003178 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 380394003179 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 380394003180 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 380394003181 protein binding site [polypeptide binding]; other site 380394003182 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 380394003183 protein binding site [polypeptide binding]; other site 380394003184 GTP-binding protein LepA; Provisional; Region: PRK05433 380394003185 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 380394003186 G1 box; other site 380394003187 putative GEF interaction site [polypeptide binding]; other site 380394003188 GTP/Mg2+ binding site [chemical binding]; other site 380394003189 Switch I region; other site 380394003190 G2 box; other site 380394003191 G3 box; other site 380394003192 Switch II region; other site 380394003193 G4 box; other site 380394003194 G5 box; other site 380394003195 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 380394003196 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 380394003197 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 380394003198 signal peptidase I; Provisional; Region: PRK10861 380394003199 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 380394003200 Catalytic site [active] 380394003201 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 380394003202 ribonuclease III; Reviewed; Region: rnc; PRK00102 380394003203 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 380394003204 dimerization interface [polypeptide binding]; other site 380394003205 active site 380394003206 metal binding site [ion binding]; metal-binding site 380394003207 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 380394003208 dsRNA binding site [nucleotide binding]; other site 380394003209 GTPase Era; Reviewed; Region: era; PRK00089 380394003210 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 380394003211 G1 box; other site 380394003212 GTP/Mg2+ binding site [chemical binding]; other site 380394003213 Switch I region; other site 380394003214 G2 box; other site 380394003215 Switch II region; other site 380394003216 G3 box; other site 380394003217 G4 box; other site 380394003218 G5 box; other site 380394003219 KH domain; Region: KH_2; pfam07650 380394003220 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 380394003221 Recombination protein O N terminal; Region: RecO_N; pfam11967 380394003222 Recombination protein O C terminal; Region: RecO_C; pfam02565 380394003223 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003 380394003224 active site 380394003225 hydrophilic channel; other site 380394003226 dimerization interface [polypeptide binding]; other site 380394003227 catalytic residues [active] 380394003228 active site lid [active] 380394003229 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 380394003230 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880 380394003231 Domain of unknown function (DUF4338); Region: DUF4338; pfam14236 380394003232 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 380394003233 RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172 380394003234 putative ribose interaction site [chemical binding]; other site 380394003235 putative ADP binding site [chemical binding]; other site 380394003236 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 380394003237 Ligand Binding Site [chemical binding]; other site 380394003238 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 380394003239 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 380394003240 dimerization interface [polypeptide binding]; other site 380394003241 domain crossover interface; other site 380394003242 redox-dependent activation switch; other site 380394003243 Toxin with endonuclease activity YhaV; Region: Toxin_YhaV; pfam11663 380394003244 putative regulator PrlF; Provisional; Region: PRK09974 380394003245 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 380394003246 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 380394003247 HsdM N-terminal domain; Region: HsdM_N; pfam12161 380394003248 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 380394003249 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4453 380394003250 Helix-turn-helix domain; Region: HTH_17; pfam12728 380394003251 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 380394003252 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 380394003253 putative active site [active] 380394003254 putative metal binding site [ion binding]; other site 380394003255 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 380394003256 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 380394003257 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 380394003258 This family is most closely related to the GT1 family of glycosyltransferases. UDP-glucose-diacylglycerol glucosyltransferase (UGDG; also known as 1,2-diacylglycerol 3-glucosyltransferase) catalyzes the transfer of glucose from UDP-glucose to 1; Region: GT1_UGDG_like; cd03817 380394003259 putative ADP-binding pocket [chemical binding]; other site 380394003260 Cytochrome c; Region: Cytochrom_C; cl11414 380394003261 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 380394003262 Cytochrome c; Region: Cytochrom_C; cl11414 380394003263 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 380394003264 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 380394003265 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 380394003266 DNA binding residues [nucleotide binding] 380394003267 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 380394003268 DEAD-like helicases superfamily; Region: DEXDc; smart00487 380394003269 ATP binding site [chemical binding]; other site 380394003270 Mg++ binding site [ion binding]; other site 380394003271 motif III; other site 380394003272 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 380394003273 nucleotide binding region [chemical binding]; other site 380394003274 ATP-binding site [chemical binding]; other site 380394003275 phosphate regulon transcriptional regulatory protein PhoB; Region: PhoB; TIGR02154 380394003276 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 380394003277 active site 380394003278 phosphorylation site [posttranslational modification] 380394003279 intermolecular recognition site; other site 380394003280 dimerization interface [polypeptide binding]; other site 380394003281 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 380394003282 DNA binding site [nucleotide binding] 380394003283 Domain of unknown function (DUF3329); Region: DUF3329; pfam11808 380394003284 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 380394003285 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 380394003286 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 380394003287 dimer interface [polypeptide binding]; other site 380394003288 phosphorylation site [posttranslational modification] 380394003289 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 380394003290 ATP binding site [chemical binding]; other site 380394003291 Mg2+ binding site [ion binding]; other site 380394003292 G-X-G motif; other site 380394003293 PBP superfamily domain; Region: PBP_like_2; cl17296 380394003294 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 380394003295 dimer interface [polypeptide binding]; other site 380394003296 conserved gate region; other site 380394003297 putative PBP binding loops; other site 380394003298 ABC-ATPase subunit interface; other site 380394003299 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 380394003300 dimer interface [polypeptide binding]; other site 380394003301 conserved gate region; other site 380394003302 putative PBP binding loops; other site 380394003303 ABC-ATPase subunit interface; other site 380394003304 phosphate transporter ATP-binding protein; Provisional; Region: pstB; PRK10744 380394003305 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 380394003306 Walker A/P-loop; other site 380394003307 ATP binding site [chemical binding]; other site 380394003308 Q-loop/lid; other site 380394003309 ABC transporter signature motif; other site 380394003310 Walker B; other site 380394003311 D-loop; other site 380394003312 H-loop/switch region; other site 380394003313 transcriptional regulator PhoU; Provisional; Region: PRK11115 380394003314 PhoU domain; Region: PhoU; pfam01895 380394003315 PhoU domain; Region: PhoU; pfam01895 380394003316 Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248 380394003317 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 380394003318 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 380394003319 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 380394003320 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 380394003321 rRNA interaction site [nucleotide binding]; other site 380394003322 S8 interaction site; other site 380394003323 putative laminin-1 binding site; other site 380394003324 elongation factor Ts; Provisional; Region: tsf; PRK09377 380394003325 UBA/TS-N domain; Region: UBA; pfam00627 380394003326 Elongation factor TS; Region: EF_TS; pfam00889 380394003327 Elongation factor TS; Region: EF_TS; pfam00889 380394003328 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 380394003329 putative nucleotide binding site [chemical binding]; other site 380394003330 uridine monophosphate binding site [chemical binding]; other site 380394003331 homohexameric interface [polypeptide binding]; other site 380394003332 ribosome recycling factor; Reviewed; Region: frr; PRK00083 380394003333 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 380394003334 hinge region; other site 380394003335 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 380394003336 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 380394003337 catalytic residue [active] 380394003338 putative FPP diphosphate binding site; other site 380394003339 putative FPP binding hydrophobic cleft; other site 380394003340 dimer interface [polypeptide binding]; other site 380394003341 putative IPP diphosphate binding site; other site 380394003342 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 380394003343 CDP-diglyceride synthase; Provisional; Region: cdsA; PRK11624 380394003344 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 380394003345 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 380394003346 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 380394003347 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 380394003348 zinc metallopeptidase RseP; Provisional; Region: PRK10779 380394003349 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 380394003350 active site 380394003351 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 380394003352 protein binding site [polypeptide binding]; other site 380394003353 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 380394003354 protein binding site [polypeptide binding]; other site 380394003355 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 380394003356 putative substrate binding region [chemical binding]; other site 380394003357 outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303 380394003358 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 380394003359 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 380394003360 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 380394003361 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 380394003362 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 380394003363 Surface antigen; Region: Bac_surface_Ag; pfam01103 380394003364 periplasmic chaperone; Provisional; Region: PRK10780 380394003365 Outer membrane protein (OmpH-like); Region: OmpH; smart00935 380394003366 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 380394003367 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 380394003368 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 380394003369 trimer interface [polypeptide binding]; other site 380394003370 active site 380394003371 UDP-GlcNAc binding site [chemical binding]; other site 380394003372 lipid binding site [chemical binding]; lipid-binding site 380394003373 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 380394003374 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 380394003375 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 380394003376 active site 380394003377 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 380394003378 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 380394003379 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 380394003380 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 380394003381 inhibitor-cofactor binding pocket; inhibition site 380394003382 pyridoxal 5'-phosphate binding site [chemical binding]; other site 380394003383 catalytic residue [active] 380394003384 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 380394003385 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 380394003386 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 380394003387 RNA/DNA hybrid binding site [nucleotide binding]; other site 380394003388 active site 380394003389 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433 380394003390 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 380394003391 putative active site [active] 380394003392 putative PHP Thumb interface [polypeptide binding]; other site 380394003393 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 380394003394 generic binding surface I; other site 380394003395 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 380394003396 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 380394003397 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 380394003398 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 380394003399 Ligand Binding Site [chemical binding]; other site 380394003400 TilS substrate binding domain; Region: TilS; pfam09179 380394003401 TilS substrate C-terminal domain; Region: TilS_C; smart00977 380394003402 dihydroorotase; Provisional; Region: PRK07575 380394003403 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 380394003404 Dihydroorotase (DHOase), subgroup IIb; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This group contains the archeal members of the DHOase family; Region: DHOase_IIb; cd01318 380394003405 active site 380394003406 RNA polymerase-binding protein DksA; Region: dksA; TIGR02420 380394003407 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 380394003408 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 380394003409 Fe2+/Zn2+ uptake regulation proteins [Inorganic ion transport and metabolism]; Region: Fur; COG0735 380394003410 metal binding site 2 [ion binding]; metal-binding site 380394003411 putative DNA binding helix; other site 380394003412 metal binding site 1 [ion binding]; metal-binding site 380394003413 dimer interface [polypeptide binding]; other site 380394003414 structural Zn2+ binding site [ion binding]; other site 380394003415 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 380394003416 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 380394003417 catalytic triad [active] 380394003418 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 380394003419 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 380394003420 putative active site [active] 380394003421 PhoH-like protein; Region: PhoH; pfam02562 380394003422 arginine decarboxylase; Provisional; Region: PRK05354 380394003423 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830 380394003424 dimer interface [polypeptide binding]; other site 380394003425 active site 380394003426 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 380394003427 catalytic residues [active] 380394003428 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 380394003429 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 380394003430 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 380394003431 glutathionine S-transferase; Provisional; Region: PRK10542 380394003432 GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057 380394003433 C-terminal domain interface [polypeptide binding]; other site 380394003434 GSH binding site (G-site) [chemical binding]; other site 380394003435 dimer interface [polypeptide binding]; other site 380394003436 C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188 380394003437 dimer interface [polypeptide binding]; other site 380394003438 substrate binding pocket (H-site) [chemical binding]; other site 380394003439 N-terminal domain interface [polypeptide binding]; other site 380394003440 Ferredoxin-like protein [Energy production and conversion]; Region: FixX; COG2440 380394003441 oxidoreductase; Provisional; Region: PRK10015 380394003442 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 380394003443 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 380394003444 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 380394003445 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 380394003446 Ligand binding site [chemical binding]; other site 380394003447 Electron transfer flavoprotein domain; Region: ETF; pfam01012 380394003448 superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280 380394003449 heme-binding site [chemical binding]; other site 380394003450 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 380394003451 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 380394003452 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 380394003453 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 380394003454 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 380394003455 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 380394003456 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 380394003457 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 380394003458 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 380394003459 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 380394003460 intersubunit interface [polypeptide binding]; other site 380394003461 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 380394003462 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 380394003463 ABC-ATPase subunit interface; other site 380394003464 dimer interface [polypeptide binding]; other site 380394003465 putative PBP binding regions; other site 380394003466 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 380394003467 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 380394003468 Walker A/P-loop; other site 380394003469 ATP binding site [chemical binding]; other site 380394003470 Q-loop/lid; other site 380394003471 ABC transporter signature motif; other site 380394003472 Walker B; other site 380394003473 D-loop; other site 380394003474 H-loop/switch region; other site 380394003475 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 380394003476 Domain of unknown function (DUF4338); Region: DUF4338; pfam14236 380394003477 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 380394003478 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880 380394003479 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 380394003480 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 380394003481 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 380394003482 Metal binding protein HemV-2. These proteins are predicted to function as initial receptors in ABC transport of metal ions. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and ligand binding...; Region: HemV-2; cd01147 380394003483 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 380394003484 putative metal binding site [ion binding]; other site 380394003485 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 380394003486 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 380394003487 ABC-ATPase subunit interface; other site 380394003488 dimer interface [polypeptide binding]; other site 380394003489 putative PBP binding regions; other site 380394003490 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 380394003491 Cation efflux family; Region: Cation_efflux; pfam01545 380394003492 This CD represents a family of iron-molybdenum cluster-binding proteins that includes NifB, NifX, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme. This...; Region: NifX_NifB; cl00252 380394003493 outer membrane porin, OprD family; Region: OprD; pfam03573 380394003494 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 380394003495 tungstate ABC transporter binding protein WtpA; Region: tungstate_WtpA; TIGR03730 380394003496 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 380394003497 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 380394003498 Walker A motif; other site 380394003499 ATP binding site [chemical binding]; other site 380394003500 Walker B motif; other site 380394003501 arginine finger; other site 380394003502 Zinc ribbon domain; Region: CxxC_CxxC_SSSS; pfam09723 380394003503 GlpE sulfurtransferase (ST) and homologs are members of the Rhodanese Homology Domain superfamily. Unlike other rhodanese sulfurtransferases, GlpE is a single domain protein but indications are that it functions as a dimer. The active site contains a...; Region: GlpE_ST; cd01444 380394003504 active site residue [active] 380394003505 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 380394003506 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 380394003507 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 380394003508 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 380394003509 NADPH bind site [chemical binding]; other site 380394003510 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 380394003511 putative FMN binding site [chemical binding]; other site 380394003512 NADPH bind site [chemical binding]; other site 380394003513 Nitrogen fixation protein NifW; Region: NifW; pfam03206 380394003514 Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762 380394003515 serine O-acetyltransferase; Region: cysE; TIGR01172 380394003516 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 380394003517 trimer interface [polypeptide binding]; other site 380394003518 active site 380394003519 substrate binding site [chemical binding]; other site 380394003520 CoA binding site [chemical binding]; other site 380394003521 homocitrate synthase NifV; Region: nifV_homocitr; TIGR02660 380394003522 Streptomyces rubellomurinus FrbC and related proteins, catalytic TIM barrel domain; Region: DRE_TIM_NifV; cd07939 380394003523 active site 380394003524 catalytic residues [active] 380394003525 metal binding site [ion binding]; metal-binding site 380394003526 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 380394003527 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 380394003528 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 380394003529 catalytic residue [active] 380394003530 Fe-S cluster assembly protein NifU; Region: NifU_proper; TIGR02000 380394003531 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 380394003532 trimerization site [polypeptide binding]; other site 380394003533 active site 380394003534 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 380394003535 NifU-like domain; Region: NifU; pfam01106 380394003536 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 380394003537 NifQ; Region: NifQ; pfam04891 380394003538 ferredoxin III, nif-specific; Region: fdxN_nitrog; TIGR02936 380394003539 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 380394003540 Rop-like; Region: Rop-like; pfam05082 380394003541 probable nitrogen fixation protein; Region: TIGR02935 380394003542 NifX belongs to a family of iron-molybdenum cluster-binding proteins that includes NifB, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme. The protein...; Region: NifX; cd00853 380394003543 Nitrogenase_nifN1: A subgroup of the NifN subunit of the NifEN complex: NifN forms an alpha2beta2 tetramer with NifE. NifN and nifE are structurally homologous to nitrogenase MoFe protein beta and alpha subunits respectively. NifEN participates in the...; Region: Nitrogenase_NifN_1; cd01966 380394003544 Nitrogenase component 1 type Oxidoreductase; Region: Oxidored_nitro; pfam00148 380394003545 nitrogenase molybdenum-iron cofactor biosynthesis protein NifE; Region: nifE; TIGR01283 380394003546 Nitrogenase_NifE_I: a subgroup of the NifE subunit of the NifEN complex: NifE forms an alpha2beta2 tetramer with NifN. NifE and NifN are structurally homologous to nitrogenase MoFe protein alpha and beta subunits respectively. NifEN participates in the...; Region: Nitrogenase_NifE_I; cd01968 380394003547 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 380394003548 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 380394003549 catalytic loop [active] 380394003550 iron binding site [ion binding]; other site 380394003551 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 380394003552 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 380394003553 catalytic loop [active] 380394003554 iron binding site [ion binding]; other site 380394003555 nitrogenase molybdenum-iron protein beta chain; Region: nifK; TIGR01286 380394003556 Domain of unknown function (DUF3364); Region: DUF3364; pfam11844 380394003557 Nitrogenase_MoFe_beta: Nitrogenase MoFe protein, beta subunit. The nitrogenase enzyme catalyzes the ATP-dependent reduction of dinitrogen to ammonia. The Molybdenum (Mo-) nitrogenase is the most widespread and best characterized of these systems; Region: Nitrogenase_MoFe_beta; cd01974 380394003558 MoFe protein beta/alpha subunit interactions; other site 380394003559 Beta subunit P cluster binding residues; other site 380394003560 MoFe protein beta subunit/Fe protein contacts; other site 380394003561 MoFe protein dimer/ dimer interactions; other site 380394003562 Nitrogenase molybdenum-iron protein, alpha and beta chains [Energy production and conversion]; Region: NifD; COG2710 380394003563 Nitrogenase_MoFe_alpha_II: Nitrogenase MoFe protein, beta subunit. A group of proteins similar to the alpha subunit of the MoFe protein of the molybdenum (Mo-) nitrogenase. The nitrogenase enzyme catalyzes the ATP-dependent reduction of dinitrogen to...; Region: Nitrogenase_MoFe_alpha; cd01976 380394003564 MoFe protein alpha/beta subunit interactions; other site 380394003565 Alpha subunit P cluster binding residues; other site 380394003566 FeMoco binding residues [chemical binding]; other site 380394003567 MoFe protein alpha subunit/Fe protein contacts; other site 380394003568 MoFe protein dimer/ dimer interactions; other site 380394003569 nitrogenase reductase; Reviewed; Region: nifH; PRK13234 380394003570 NifH gene encodes component II (iron protein) of nitrogenase. Nitrogenase is responsible for the biological nitrogen fixation, i.e. reduction of molecular nitrogen to ammonia. NifH consists of two oxygen-sensitive metallosulfur proteins: the...; Region: NifH; cd02040 380394003571 Nucleotide-binding sites [chemical binding]; other site 380394003572 Walker A motif; other site 380394003573 Switch I region of nucleotide binding site; other site 380394003574 Fe4S4 binding sites [ion binding]; other site 380394003575 Switch II region of nucleotide binding site; other site 380394003576 Response regulator receiver domain; Region: Response_reg; pfam00072 380394003577 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 380394003578 active site 380394003579 phosphorylation site [posttranslational modification] 380394003580 dimerization interface [polypeptide binding]; other site 380394003581 Dinitrogenase reductase ADP-ribosyltransferase (DRAT); Region: DRAT; pfam07357 380394003582 ADP-ribosyl-[dinitrogen reductase] hydrolase; Region: dinitro_DRAG; TIGR02662 380394003583 Arsenate Reductase (ArsC) family, 15kD protein subfamily; composed of proteins of unknown function with similarity to thioredoxin-fold arsenic reductases, ArsC. It is encoded by an ORF present in a gene cluster associated with nitrogen fixation that also...; Region: ArsC_15kD; cd03033 380394003584 ArsC family; Region: ArsC; pfam03960 380394003585 putative catalytic residues [active] 380394003586 Nif-specific regulatory protein; Region: nifA; TIGR01817 380394003587 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 380394003588 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 380394003589 Walker A motif; other site 380394003590 ATP binding site [chemical binding]; other site 380394003591 Walker B motif; other site 380394003592 arginine finger; other site 380394003593 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 380394003594 nitrogenase cofactor biosynthesis protein NifB; Region: nifB; TIGR01290 380394003595 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 380394003596 FeS/SAM binding site; other site 380394003597 NifB belongs to a family of iron-molybdenum cluster-binding proteins that includes NifX, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme as part of...; Region: NifB; cd00852 380394003598 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 380394003599 Iron-sulfur cluster assembly accessory protein; Region: TIGR00049 380394003600 LRV protein FeS4 cluster; Region: LRV_FeS; pfam05484 380394003601 HEAT repeats; Region: HEAT_2; pfam13646 380394003602 Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin; Region: ARM; cl02500 380394003603 protein binding surface [polypeptide binding]; other site 380394003604 NifZ domain; Region: NifZ; pfam04319 380394003605 NifZ domain; Region: NifZ; pfam04319 380394003606 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 380394003607 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 380394003608 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 380394003609 catalytic residue [active] 380394003610 NifT/FixU protein; Region: NifT; pfam06988 380394003611 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 380394003612 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 380394003613 inhibitor-cofactor binding pocket; inhibition site 380394003614 pyridoxal 5'-phosphate binding site [chemical binding]; other site 380394003615 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 380394003616 catalytic loop [active] 380394003617 iron binding site [ion binding]; other site 380394003618 SIR2-like domain; Region: SIR2_2; pfam13289 380394003619 molybdenum transport protein ModD; Provisional; Region: PRK06096 380394003620 ModD; Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase) present in some modABC operons in bacteria, which are involved in molybdate transport. In general, QPRTases are part of the de novo synthesis pathway of NAD in both prokaryotes and...; Region: modD_like; cd01573 380394003621 dimerization interface [polypeptide binding]; other site 380394003622 active site 380394003623 Molybdopterin-binding protein [Coenzyme metabolism]; Region: MopI; COG3585 380394003624 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 380394003625 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 380394003626 tetramerization interface [polypeptide binding]; other site 380394003627 NAD(P) binding site [chemical binding]; other site 380394003628 catalytic residues [active] 380394003629 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 380394003630 apolar tunnel; other site 380394003631 heme binding site [chemical binding]; other site 380394003632 dimerization interface [polypeptide binding]; other site 380394003633 Mechanosensitive ion channel; Region: MS_channel; pfam00924 380394003634 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 380394003635 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 380394003636 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 380394003637 putative substrate binding site [chemical binding]; other site 380394003638 putative ATP binding site [chemical binding]; other site 380394003639 sucrose-phosphate synthase, putative, glycosyltransferase domain; Region: sucr_P_syn_N; TIGR02472 380394003640 This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800 380394003641 putative ADP-binding pocket [chemical binding]; other site 380394003642 sucrose phosphate synthase, sucrose phosphatase-like domain, bacterial; Region: sucr_syn_bact_C; TIGR02471 380394003643 sucrose synthase; Region: sucr_synth; TIGR02470 380394003644 This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800 380394003645 putative ADP-binding pocket [chemical binding]; other site 380394003646 O-6-alkylguanine-DNA:cysteine-protein methyltransferase; Provisional; Region: PRK10286 380394003647 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 380394003648 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 380394003649 DNA binding site [nucleotide binding] 380394003650 active site 380394003651 Domain of unknown function (DUF202); Region: DUF202; cl09954 380394003652 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 380394003653 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 380394003654 active site 380394003655 DNA binding site [nucleotide binding] 380394003656 Int/Topo IB signature motif; other site 380394003657 transcriptional repressor DicA; Reviewed; Region: PRK09706 380394003658 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 380394003659 non-specific DNA binding site [nucleotide binding]; other site 380394003660 salt bridge; other site 380394003661 sequence-specific DNA binding site [nucleotide binding]; other site 380394003662 Protein of unknown function (DUF1376); Region: DUF1376; cl01531 380394003663 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 380394003664 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 380394003665 Walker A motif; other site 380394003666 ATP binding site [chemical binding]; other site 380394003667 Walker B motif; other site 380394003668 arginine finger; other site 380394003669 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dam; COG0338 380394003670 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 380394003671 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 380394003672 dimer interface [polypeptide binding]; other site 380394003673 ssDNA binding site [nucleotide binding]; other site 380394003674 tetramer (dimer of dimers) interface [polypeptide binding]; other site 380394003675 NACHT domain; Region: NACHT; pfam05729 380394003676 T5orf172 domain; Region: T5orf172; pfam10544 380394003677 DEAD-like helicases superfamily; Region: DEXDc; smart00487 380394003678 Pseudomurein-binding repeat; Region: PMBR; pfam09373 380394003679 Divergent AAA domain; Region: AAA_4; pfam04326 380394003680 Type II restriction enzyme, methylase subunits [Defense mechanisms]; Region: COG1002 380394003681 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 380394003682 PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 380394003683 putative active site [active] 380394003684 Uncharacterized protein conserved in bacteria (DUF2191); Region: DUF2191; pfam09957 380394003685 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 380394003686 IHF dimer interface [polypeptide binding]; other site 380394003687 IHF - DNA interface [nucleotide binding]; other site 380394003688 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 380394003689 IHF dimer interface [polypeptide binding]; other site 380394003690 IHF - DNA interface [nucleotide binding]; other site 380394003691 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cl00257 380394003692 IHF dimer interface [polypeptide binding]; other site 380394003693 IHF - DNA interface [nucleotide binding]; other site 380394003694 addiction module antitoxin, RelB/DinJ family; Region: RelB_DinJ; TIGR02384 380394003695 Phosphate acyltransferases; Region: PlsC; smart00563 380394003696 putative acyl-acceptor binding pocket; other site 380394003697 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 380394003698 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843 380394003699 Antirestriction protein [DNA replication, recombination, and repair]; Region: COG4227 380394003700 Domain of unknown function (DUF1738); Region: DUF1738; pfam08401 380394003701 Domain of unknown function (DUF3560); Region: DUF3560; pfam12083 380394003702 Transposase; Region: DEDD_Tnp_IS110; pfam01548 380394003703 Domain of unknown function (DUF4415); Region: DUF4415; pfam14384 380394003704 Protein of unknown function (DUF497); Region: DUF497; cl01108 380394003705 Type IV secretory pathway, VirD2 components (relaxase) [Intracellular trafficking and secretion]; Region: VirD2; COG3843 380394003706 Protein of unknown function (DUF3363); Region: DUF3363; pfam11843 380394003707 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 380394003708 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 380394003709 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 380394003710 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 380394003711 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 380394003712 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 380394003713 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 380394003714 putative addiction module killer protein; Region: upstrm_HI1419; TIGR02683 380394003715 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 380394003716 non-specific DNA binding site [nucleotide binding]; other site 380394003717 sequence-specific DNA binding site [nucleotide binding]; other site 380394003718 salt bridge; other site 380394003719 P-type conjugative transfer ATPase TrbB; Region: TrbB_P; TIGR02782 380394003720 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 380394003721 ATP binding site [chemical binding]; other site 380394003722 Walker A motif; other site 380394003723 hexamer interface [polypeptide binding]; other site 380394003724 Walker B motif; other site 380394003725 Type IV secretory pathway, VirB3-like protein; Region: VirB3; cl01501 380394003726 conjugal transfer ATPase TrbE; Provisional; Region: PRK13873 380394003727 CagE, TrbE, VirB family, component of type IV transporter system; Region: CagE_TrbE_VirB; pfam03135 380394003728 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 380394003729 Walker B; other site 380394003730 D-loop; other site 380394003731 H-loop/switch region; other site 380394003732 P-type conjugative transfer protein TrbJ; Region: TrbJ_Ti; TIGR02780 380394003733 P-type conjugative transfer protein TrbL; Region: TrbL_P; TIGR02783 380394003734 Phosphate-starvation-inducible E; Region: PsiE; pfam06146 380394003735 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 380394003736 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 380394003737 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 380394003738 protein binding site [polypeptide binding]; other site 380394003739 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 380394003740 protein binding site [polypeptide binding]; other site 380394003741 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 380394003742 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 380394003743 putative dimer interface [polypeptide binding]; other site 380394003744 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 380394003745 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 380394003746 oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701 380394003747 The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767 380394003748 putative molybdopterin cofactor binding site [chemical binding]; other site 380394003749 The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787 380394003750 putative molybdopterin cofactor binding site; other site 380394003751 FdhD/NarQ family; Region: FdhD-NarQ; cl00659 380394003752 Winged helix-turn helix; Region: HTH_33; pfam13592 380394003753 DDE superfamily endonuclease; Region: DDE_3; pfam13358 380394003754 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 380394003755 anthranilate dioxygenase reductase; Provisional; Region: antC; PRK11872 380394003756 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 380394003757 catalytic loop [active] 380394003758 iron binding site [ion binding]; other site 380394003759 Methane monooxygenase (MMO) reductase of methanotrophs catalyzes the NADH-dependent hydroxylation of methane to methanol. This multicomponent enzyme mediates electron transfer via a hydroxylase (MMOH), a coupling protein, and a reductase which is...; Region: MMO_FAD_NAD_binding; cd06210 380394003760 FAD binding pocket [chemical binding]; other site 380394003761 FAD binding motif [chemical binding]; other site 380394003762 phosphate binding motif [ion binding]; other site 380394003763 beta-alpha-beta structure motif; other site 380394003764 NAD binding pocket [chemical binding]; other site 380394003765 hybrid cluster protein; Provisional; Region: PRK05290 380394003766 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 380394003767 ACS interaction site; other site 380394003768 CODH interaction site; other site 380394003769 Hybrid cluster protein (HCP), formerly known as prismane, is thought to play a role in nitrogen metabolism but its specific function is unknown. HCP has three structural domains, an N-terminal alpha-helical domain, and two similar domains comprising a...; Region: HCP; cd01914 380394003770 hybrid metal cluster; other site 380394003771 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 380394003772 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 380394003773 ligand binding site [chemical binding]; other site 380394003774 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 380394003775 putative switch regulator; other site 380394003776 non-specific DNA interactions [nucleotide binding]; other site 380394003777 DNA binding site [nucleotide binding] 380394003778 sequence specific DNA binding site [nucleotide binding]; other site 380394003779 putative cAMP binding site [chemical binding]; other site 380394003780 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3002 380394003781 Uncharacterized protein conserved in bacteria (DUF2309); Region: DUF2309; pfam10070 380394003782 NADH dehydrogenase subunit L; Provisional; Region: PRK08168 380394003783 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 380394003784 glycolate oxidase iron-sulfur subunit; Provisional; Region: glcF; PRK11274 380394003785 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 380394003786 Cysteine-rich domain; Region: CCG; pfam02754 380394003787 Cysteine-rich domain; Region: CCG; pfam02754 380394003788 glycolate oxidase FAD binding subunit; Provisional; Region: glcE; PRK11282 380394003789 FAD binding domain; Region: FAD_binding_4; pfam01565 380394003790 glycolate oxidase subunit GlcD; Provisional; Region: PRK11230 380394003791 FAD binding domain; Region: FAD_binding_4; pfam01565 380394003792 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395 380394003793 Phosphoketolase [Carbohydrate transport and metabolism]; Region: COG3957 380394003794 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 380394003795 TPP-binding site [chemical binding]; other site 380394003796 Transketolase, pyrimidine binding domain; Region: Transket_pyr; smart00861 380394003797 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 380394003798 Transcriptional regulator [Transcription]; Region: IclR; COG1414 380394003799 Bacterial transcriptional regulator; Region: IclR; pfam01614 380394003800 Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294 380394003801 active site 380394003802 substrate binding pocket [chemical binding]; other site 380394003803 dimer interface [polypeptide binding]; other site 380394003804 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 380394003805 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 380394003806 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 380394003807 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 380394003808 AAA domain; Region: AAA_26; pfam13500 380394003809 Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1,6-bisphosphate (FBP) and tagarose 1,6-bisphosphate (TBP) aldolases. FBP-aldolase is homodimeric and used in gluconeogenesis and glycolysis; the enzyme controls the...; Region: FTBP_aldolase_II; cl17181 380394003810 active site 380394003811 intersubunit interface [polypeptide binding]; other site 380394003812 zinc binding site [ion binding]; other site 380394003813 Na+ binding site [ion binding]; other site 380394003814 Stress responsive A/B Barrel Domain; Region: Dabb; smart00886 380394003815 norD type: Denitrifying bacteria contain both membrane bound and periplasmic nitrate reductases. Denitrification plays a major role in completing the nitrogen cycle by converting nitrate or nitrite to nitrogen gas. The pathway for microbial...; Region: vWA_norD_type; cd01454 380394003816 metal ion-dependent adhesion site (MIDAS); other site 380394003817 MoxR-like ATPases [General function prediction only]; Region: COG0714 380394003818 AAA domain (dynein-related subfamily); Region: AAA_5; pfam07728 380394003819 Walker A motif; other site 380394003820 ATP binding site [chemical binding]; other site 380394003821 Walker B motif; other site 380394003822 CbbQ/NirQ/NorQ C-terminal; Region: CbbQ_C; pfam08406 380394003823 ParA-like protein; Provisional; Region: PHA02518 380394003824 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 380394003825 P-loop; other site 380394003826 Magnesium ion binding site [ion binding]; other site 380394003827 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH; cl00942 380394003828 DCoH dimer interaction site [polypeptide binding]; other site 380394003829 aromatic arch; other site 380394003830 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 380394003831 DCoH tetramer interaction site [polypeptide binding]; other site 380394003832 substrate binding site [chemical binding]; other site 380394003833 Ferritin-like domain; Region: Ferritin; pfam00210 380394003834 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 380394003835 dinuclear metal binding motif [ion binding]; other site 380394003836 Carboxysome Shell 1 (CsoS1); Bacterial Micro-Compartment (BCM) domain; Region: BMC_CsoS1; cd07058 380394003837 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 380394003838 Hexamer interface [polypeptide binding]; other site 380394003839 Hexagonal pore residue; other site 380394003840 Hexagonal pore; other site 380394003841 Carboxysome Shell 1 (CsoS1); Bacterial Micro-Compartment (BCM) domain; Region: BMC_CsoS1; cd07058 380394003842 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 380394003843 Hexamer interface [polypeptide binding]; other site 380394003844 Hexagonal pore residue; other site 380394003845 Hexagonal pore; other site 380394003846 Carboxysome Shell 1 (CsoS1); Bacterial Micro-Compartment (BCM) domain; Region: BMC_CsoS1; cd07058 380394003847 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 380394003848 Hexamer interface [polypeptide binding]; other site 380394003849 Hexagonal pore residue; other site 380394003850 Hexagonal pore; other site 380394003851 Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614 380394003852 Hexamer/Pentamer interface [polypeptide binding]; other site 380394003853 central pore; other site 380394003854 Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614 380394003855 Hexamer/Pentamer interface [polypeptide binding]; other site 380394003856 central pore; other site 380394003857 carboxysome shell carbonic anhydrase; Region: shell_carb_anhy; TIGR02701 380394003858 Carboxysome shell peptide mid-region; Region: CsoS2_M; pfam12288 380394003859 Carboxysome shell peptide mid-region; Region: CsoS2_M; pfam12288 380394003860 Ribulose bisphosphate carboxylase/oxygenase (Rubisco), small subunit. Rubisco is a bifunctional enzyme catalyzes the initial steps of two opposing metabolic pathways: photosynthetic carbon fixation and the competing process of photorespiration. Rubisco...; Region: RuBisCO_small; cd03527 380394003861 multimerization interface [polypeptide binding]; other site 380394003862 ribulose bisophosphate carboxylase; Reviewed; Region: rbcL; PRK04208 380394003863 Ribulose bisphosphate carboxylase large chain; Region: RuBisCO_large; cl08232 380394003864 dimer interface [polypeptide binding]; other site 380394003865 catalytic residue [active] 380394003866 metal binding site [ion binding]; metal-binding site 380394003867 Transcriptional regulator [Transcription]; Region: LysR; COG0583 380394003868 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 380394003869 The C-terminal substrate binding of LysR-type transcriptional regulator (CbbR) of RubisCO operon, which is involved in the carbon dioxide fixation, contains the type 2 periplasmic binding fold; Region: PBP2_CbbR_RubisCO_like; cd08419 380394003870 putative dimerization interface [polypeptide binding]; other site 380394003871 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472 380394003872 VirB8 protein; Region: VirB8; pfam04335 380394003873 VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cd06911 380394003874 VirB7 interaction site; other site 380394003875 VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cl11423 380394003876 Bacterial conjugation TrbI-like protein; Region: TrbI; pfam03743 380394003877 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 380394003878 N-acetyl-D-glucosamine binding site [chemical binding]; other site 380394003879 catalytic residue [active] 380394003880 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 380394003881 Type IV secretion-system coupling protein DNA-binding domain; Region: TrwB_AAD_bind; pfam10412 380394003882 Walker A motif; other site 380394003883 ATP binding site [chemical binding]; other site 380394003884 Walker B motif; other site 380394003885 Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016 380394003886 PilZ domain; Region: PilZ; pfam07238 380394003887 superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280 380394003888 heme-binding site [chemical binding]; other site 380394003889 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 380394003890 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 380394003891 metal binding site [ion binding]; metal-binding site 380394003892 active site 380394003893 I-site; other site 380394003894 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 380394003895 MCP-signal associated domain; Region: MCPsignal_assoc; pfam13682 380394003896 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 380394003897 PLD-like domain; Region: PLDc_2; pfam13091 380394003898 putative active site [active] 380394003899 catalytic site [active] 380394003900 Putative catalytic domain, repeat 2, of uncharacterized phospholipase D-like proteins; Region: PLDc_unchar1_2; cd09128 380394003901 PLD-like domain; Region: PLDc_2; pfam13091 380394003902 putative active site [active] 380394003903 putative catalytic site [active] 380394003904 ParB-like nuclease domain; Region: ParBc; pfam02195 380394003905 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 380394003906 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 380394003907 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 380394003908 P-loop; other site 380394003909 Magnesium ion binding site [ion binding]; other site 380394003910 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 380394003911 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 380394003912 active site 380394003913 catalytic tetrad [active] 380394003914 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 380394003915 PAS domain; Region: PAS_9; pfam13426 380394003916 putative active site [active] 380394003917 heme pocket [chemical binding]; other site 380394003918 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 380394003919 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 380394003920 metal binding site [ion binding]; metal-binding site 380394003921 active site 380394003922 I-site; other site 380394003923 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 380394003924 MCP-signal associated domain; Region: MCPsignal_assoc; pfam13682 380394003925 Signal peptidase, peptidase S26; Region: Peptidase_S26; pfam10502 380394003926 conjugal transfer pilin processing protease TraF; Provisional; Region: PRK13838 380394003927 Predicted transcriptional regulator [Transcription]; Region: COG4190 380394003928 MarR family; Region: MarR_2; pfam12802 380394003929 conjugal transfer protein TraB; Provisional; Region: PRK13825 380394003930 active site 380394003931 catalytic triad [active] 380394003932 dimer interface [polypeptide binding]; other site 380394003933 YcfA-like protein; Region: YcfA; cl00752 380394003934 Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681 380394003935 probable addiction module antidote protein; Region: dnstrm_HI1420; TIGR02684 380394003936 DNA topoisomerase III; Provisional; Region: PRK07726 380394003937 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 380394003938 active site 380394003939 putative interdomain interaction site [polypeptide binding]; other site 380394003940 putative metal-binding site [ion binding]; other site 380394003941 putative nucleotide binding site [chemical binding]; other site 380394003942 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 380394003943 domain I; other site 380394003944 DNA binding groove [nucleotide binding] 380394003945 phosphate binding site [ion binding]; other site 380394003946 domain II; other site 380394003947 domain III; other site 380394003948 nucleotide binding site [chemical binding]; other site 380394003949 catalytic site [active] 380394003950 domain IV; other site 380394003951 putative transposase OrfB; Reviewed; Region: PHA02517 380394003952 HTH-like domain; Region: HTH_21; pfam13276 380394003953 Integrase core domain; Region: rve; pfam00665 380394003954 Integrase core domain; Region: rve_3; pfam13683 380394003955 Transposase; Region: HTH_Tnp_1; cl17663 380394003956 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 380394003957 active site 380394003958 Glutathione-dependent formaldehyde-activating enzyme; Region: GFA; cl01553 380394003959 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379 380394003960 active site clefts [active] 380394003961 zinc binding site [ion binding]; other site 380394003962 dimer interface [polypeptide binding]; other site 380394003963 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 380394003964 active site 380394003965 DNA polymerase IV; Validated; Region: PRK02406 380394003966 DNA binding site [nucleotide binding] 380394003967 Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502 380394003968 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 380394003969 putative active site [active] 380394003970 catalytic site [active] 380394003971 Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase ybhO and similar proteins; Region: PLDc_ybhO_like_2; cd09159 380394003972 putative active site [active] 380394003973 catalytic site [active] 380394003974 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 380394003975 MutS domain I; Region: MutS_I; pfam01624 380394003976 MutS domain II; Region: MutS_II; pfam05188 380394003977 MutS domain III; Region: MutS_III; pfam05192 380394003978 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 380394003979 Walker A/P-loop; other site 380394003980 ATP binding site [chemical binding]; other site 380394003981 Q-loop/lid; other site 380394003982 ABC transporter signature motif; other site 380394003983 Walker B; other site 380394003984 D-loop; other site 380394003985 H-loop/switch region; other site 380394003986 Protein of unknown function (DUF465); Region: DUF465; cl01070 380394003987 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cl00723 380394003988 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 380394003989 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 380394003990 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 380394003991 YccA-like proteins; Region: YccA_like; cd10433 380394003992 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 380394003993 exodeoxyribonuclease X; Provisional; Region: PRK07983 380394003994 active site 380394003995 catalytic site [active] 380394003996 substrate binding site [chemical binding]; other site 380394003997 Protein of unknown function (DUF3820); Region: DUF3820; cl01411 380394003998 Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; pfam00596 380394003999 Smr domain; Region: Smr; cl02619 380394004000 Protein of unknown function (DUF3683); Region: DUF3683; pfam12447 380394004001 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 380394004002 FAD binding domain; Region: FAD_binding_4; pfam01565 380394004003 FAD linked oxidases, C-terminal domain; Region: FAD-oxidase_C; pfam02913 380394004004 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 380394004005 Cysteine-rich domain; Region: CCG; pfam02754 380394004006 Domain of unknown function (DUF3400); Region: DUF3400; pfam11880 380394004007 pantoate--beta-alanine ligase; Region: panC; TIGR00018 380394004008 Pantoate-beta-alanine ligase; Region: PanC; cd00560 380394004009 active site 380394004010 ATP-binding site [chemical binding]; other site 380394004011 pantoate-binding site; other site 380394004012 HXXH motif; other site 380394004013 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 380394004014 oligomerization interface [polypeptide binding]; other site 380394004015 active site 380394004016 metal binding site [ion binding]; metal-binding site 380394004017 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 380394004018 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 380394004019 Substrate-binding site [chemical binding]; other site 380394004020 Substrate specificity [chemical binding]; other site 380394004021 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 380394004022 catalytic center binding site [active] 380394004023 ATP binding site [chemical binding]; other site 380394004024 tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617 380394004025 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 380394004026 active site 380394004027 NTP binding site [chemical binding]; other site 380394004028 metal binding triad [ion binding]; metal-binding site 380394004029 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 380394004030 poly(A) polymerase; Region: pcnB; TIGR01942 380394004031 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 380394004032 active site 380394004033 NTP binding site [chemical binding]; other site 380394004034 metal binding triad [ion binding]; metal-binding site 380394004035 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 380394004036 Polymerase A arginine-rich C-terminus; Region: PolyA_pol_arg_C; pfam12626 380394004037 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 380394004038 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 380394004039 Ligand binding site; other site 380394004040 Putative Catalytic site; other site 380394004041 DXD motif; other site 380394004042 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 380394004043 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 380394004044 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 380394004045 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 380394004046 active site 380394004047 GMP synthase; Reviewed; Region: guaA; PRK00074 380394004048 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 380394004049 AMP/PPi binding site [chemical binding]; other site 380394004050 candidate oxyanion hole; other site 380394004051 catalytic triad [active] 380394004052 potential glutamine specificity residues [chemical binding]; other site 380394004053 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 380394004054 ATP Binding subdomain [chemical binding]; other site 380394004055 Ligand Binding sites [chemical binding]; other site 380394004056 Dimerization subdomain; other site 380394004057 Plasmid stability protein [General function prediction only]; Region: StbC; COG4691 380394004058 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 380394004059 oligomeric interface; other site 380394004060 putative active site [active] 380394004061 homodimer interface [polypeptide binding]; other site 380394004062 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 380394004063 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 380394004064 gamma-glutamyl kinase; Provisional; Region: PRK05429 380394004065 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 380394004066 nucleotide binding site [chemical binding]; other site 380394004067 homotetrameric interface [polypeptide binding]; other site 380394004068 putative phosphate binding site [ion binding]; other site 380394004069 putative allosteric binding site; other site 380394004070 PUA domain; Region: PUA; pfam01472 380394004071 Mechanosensitive ion channel; Region: MS_channel; pfam00924 380394004072 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 380394004073 dinuclear metal binding motif [ion binding]; other site 380394004074 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 380394004075 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 380394004076 Peptidase family M50; Region: Peptidase_M50; pfam02163 380394004077 active site 380394004078 putative substrate binding region [chemical binding]; other site 380394004079 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 380394004080 active site 380394004081 HIGH motif; other site 380394004082 dimer interface [polypeptide binding]; other site 380394004083 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 380394004084 active site 380394004085 KMSKS motif; other site 380394004086 ScpA/B protein; Region: ScpA_ScpB; cl00598 380394004087 Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079 380394004088 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 380394004089 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 380394004090 NAD binding site [chemical binding]; other site 380394004091 23S rRNA pseudouridylate synthase B; Provisional; Region: PRK10700 380394004092 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 380394004093 RNA binding surface [nucleotide binding]; other site 380394004094 Pseudouridine synthase, Escherichia coli RluB like; Region: PseudoU_synth_RluB; cd02556 380394004095 probable active site [active] 380394004096 Uncharacterized protein related to Endonuclease III [DNA replication, recombination, and repair]; Region: COG2231 380394004097 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 380394004098 minor groove reading motif; other site 380394004099 helix-hairpin-helix signature motif; other site 380394004100 substrate binding pocket [chemical binding]; other site 380394004101 active site 380394004102 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 380394004103 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 380394004104 putative substrate translocation pore; other site 380394004105 Short repeat of unknown function (DUF308); Region: DUF308; cl15828 380394004106 This family is most closely related to the oligosaccharide phosphorylase domain family and other unidentified sequences. Oligosaccharide phosphorylase catalyzes the breakdown of oligosaccharides into glucose-1-phosphate units. They are important...; Region: GT1_Glycogen_Phosphorylase_like; cd04299 380394004107 putative homodimer interface [polypeptide binding]; other site 380394004108 putative active site pocket [active] 380394004109 alpha-glucan phosphorylases; Region: more_P_ylases; TIGR02094 380394004110 pyruvate kinase; Provisional; Region: PRK05826 380394004111 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 380394004112 domain interfaces; other site 380394004113 active site 380394004114 DhnA-type fructose-1,6-bisphosphate aldolase and related enzymes [Carbohydrate transport and metabolism]; Region: FbaB; COG1830 380394004115 Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958 380394004116 putative active site; other site 380394004117 catalytic residue [active] 380394004118 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 380394004119 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 380394004120 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 380394004121 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 380394004122 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 380394004123 putative substrate binding site [chemical binding]; other site 380394004124 putative ATP binding site [chemical binding]; other site 380394004125 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl17212 380394004126 phosphate:H+ symporter; Region: 2A0109; TIGR00887 380394004127 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 380394004128 putative substrate translocation pore; other site 380394004129 Domain of unknown function (DUF4338); Region: DUF4338; pfam14236 380394004130 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 380394004131 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 380394004132 E3 interaction surface; other site 380394004133 lipoyl attachment site [posttranslational modification]; other site 380394004134 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11857 380394004135 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 380394004136 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 380394004137 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 380394004138 alpha subunit interface [polypeptide binding]; other site 380394004139 TPP binding site [chemical binding]; other site 380394004140 heterodimer interface [polypeptide binding]; other site 380394004141 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 380394004142 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182 380394004143 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 380394004144 tetramer interface [polypeptide binding]; other site 380394004145 TPP-binding site [chemical binding]; other site 380394004146 heterodimer interface [polypeptide binding]; other site 380394004147 phosphorylation loop region [posttranslational modification] 380394004148 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 380394004149 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 380394004150 phosphoglyceromutase; Provisional; Region: PRK05434 380394004151 phosphoenolpyruvate synthase; Validated; Region: PRK06464 380394004152 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 380394004153 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 380394004154 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 380394004155 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 380394004156 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 380394004157 Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797 380394004158 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 380394004159 Sporulation related domain; Region: SPOR; pfam05036 380394004160 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009 380394004161 M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891 380394004162 metal binding site [ion binding]; metal-binding site 380394004163 dimer interface [polypeptide binding]; other site 380394004164 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830 380394004165 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 380394004166 trimer interface [polypeptide binding]; other site 380394004167 active site 380394004168 substrate binding site [chemical binding]; other site 380394004169 CoA binding site [chemical binding]; other site 380394004170 succinyldiaminopimelate transaminase; Region: DapC_gpp; TIGR03538 380394004171 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 380394004172 pyridoxal 5'-phosphate binding site [chemical binding]; other site 380394004173 homodimer interface [polypeptide binding]; other site 380394004174 catalytic residue [active] 380394004175 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 380394004176 phosphoglycolate phosphatase; Provisional; Region: PRK13226 380394004177 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 380394004178 motif II; other site 380394004179 bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134 380394004180 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 380394004181 S-adenosylmethionine binding site [chemical binding]; other site 380394004182 N-ethylammeline chlorohydrolase; Provisional; Region: PRK09045 380394004183 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 380394004184 active site 380394004185 putative substrate binding pocket [chemical binding]; other site 380394004186 Transglycosylase SLT domain; Region: SLT_2; pfam13406 380394004187 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 380394004188 N-acetyl-D-glucosamine binding site [chemical binding]; other site 380394004189 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 380394004190 NlpC/P60 family; Region: NLPC_P60; pfam00877 380394004191 Toluene tolerance, Ttg2; Region: Tol_Tol_Ttg2; pfam05494 380394004192 Lipid A 3-O-deacylase (PagL); Region: PagL; pfam09411 380394004193 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; pfam13640 380394004194 RNA polymerase sigma factor RpoS; Validated; Region: PRK05657 380394004195 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 380394004196 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 380394004197 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 380394004198 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 380394004199 DNA binding residues [nucleotide binding] 380394004200 Domain of unknown function (DUF4338); Region: DUF4338; pfam14236 380394004201 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 380394004202 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880 380394004203 Domain of unknown function (DUF4338); Region: DUF4338; pfam14236 380394004204 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 380394004205 transposase; Validated; Region: PRK08181 380394004206 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 380394004207 Walker A motif; other site 380394004208 ATP binding site [chemical binding]; other site 380394004209 Integrase core domain; Region: rve; pfam00665 380394004210 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 380394004211 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 380394004212 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 380394004213 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 380394004214 TPP-binding site [chemical binding]; other site 380394004215 dimer interface [polypeptide binding]; other site 380394004216 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 380394004217 PYR/PP interface [polypeptide binding]; other site 380394004218 dimer interface [polypeptide binding]; other site 380394004219 TPP binding site [chemical binding]; other site 380394004220 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 380394004221 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 380394004222 4Fe-4S binding domain; Region: Fer4; pfam00037 380394004223 Domain of unknown function (DUF3470); Region: DUF3470; pfam11953 380394004224 Domain of unknown function (DUF1971); Region: DUF1971; cl17717 380394004225 Protein of unknown function (DUF2945); Region: DUF2945; pfam11160 380394004226 Tellurite resistance protein and related permeases [Inorganic ion transport and metabolism]; Region: TehA; COG1275 380394004227 The Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT_like_1; cd09319 380394004228 gating phenylalanine in ion channel; other site 380394004229 AlkA N-terminal domain; Region: AlkA_N; cl05528 380394004230 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 380394004231 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 380394004232 minor groove reading motif; other site 380394004233 helix-hairpin-helix signature motif; other site 380394004234 active site 380394004235 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 380394004236 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 380394004237 active site 380394004238 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 380394004239 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 380394004240 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 380394004241 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 380394004242 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 380394004243 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 380394004244 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 380394004245 NAD(P) binding site [chemical binding]; other site 380394004246 active site 380394004247 Glycoside hydrolase family 15, N-terminal domain; Region: GH15_N; cl07672 380394004248 Domain interface; other site 380394004249 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH_subfamily_a; cd00913 380394004250 aromatic arch; other site 380394004251 DCoH dimer interaction site [polypeptide binding]; other site 380394004252 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 380394004253 DCoH tetramer interaction site [polypeptide binding]; other site 380394004254 substrate binding site [chemical binding]; other site 380394004255 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 380394004256 metal-binding site [ion binding] 380394004257 Superinfection immunity protein; Region: Imm_superinfect; pfam14373 380394004258 AAA domain; Region: AAA_33; pfam13671 380394004259 Uncharacterized protein conserved in bacteria (DUF2147); Region: DUF2147; pfam09917 380394004260 LexA repressor; Validated; Region: PRK00215 380394004261 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 380394004262 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 380394004263 Catalytic site [active] 380394004264 Cell division inhibitor SulA; Region: SulA; cl01880 380394004265 DNA Polymerase Y-family; Region: PolY_like; cd03468 380394004266 active site 380394004267 Nucleotidyltransferase/DNA polymerase involved in DNA repair [DNA replication, recombination, and repair]; Region: DinP; COG0389 380394004268 DNA binding site [nucleotide binding] 380394004269 error-prone DNA polymerase; Validated; Region: dnaE2; PRK05672 380394004270 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at DnaE2 gene; Region: PHP_PolIIIA_DnaE2; cd07434 380394004271 putative active site [active] 380394004272 putative PHP Thumb interface [polypeptide binding]; other site 380394004273 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 380394004274 generic binding surface II; other site 380394004275 generic binding surface I; other site 380394004276 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 380394004277 aminopeptidase N; Provisional; Region: pepN; PRK14015 380394004278 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_1; cd09600 380394004279 active site 380394004280 Zn binding site [ion binding]; other site 380394004281 Uncharacterized subgroup of the CYTH-like superfamily having an associated CHAD domain; Region: CYTH-like_Pase_CHAD; cd07756 380394004282 putative active site [active] 380394004283 putative metal binding residues [ion binding]; other site 380394004284 signature motif; other site 380394004285 putative triphosphate binding site [ion binding]; other site 380394004286 CHAD domain; Region: CHAD; pfam05235 380394004287 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 380394004288 ParA-like protein; Provisional; Region: PHA02518 380394004289 P-loop; other site 380394004290 Magnesium ion binding site [ion binding]; other site 380394004291 polyphosphate kinase; Provisional; Region: PRK05443 380394004292 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 380394004293 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 380394004294 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 380394004295 putative domain interface [polypeptide binding]; other site 380394004296 putative active site [active] 380394004297 catalytic site [active] 380394004298 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 380394004299 putative domain interface [polypeptide binding]; other site 380394004300 putative active site [active] 380394004301 catalytic site [active] 380394004302 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK10792 380394004303 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 380394004304 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 380394004305 homodimer interface [polypeptide binding]; other site 380394004306 NADP binding site [chemical binding]; other site 380394004307 substrate binding site [chemical binding]; other site 380394004308 multidrug efflux protein; Reviewed; Region: PRK09579 380394004309 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 380394004310 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 380394004311 HlyD family secretion protein; Region: HlyD_3; pfam13437 380394004312 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 380394004313 Tetratricopeptide repeat; Region: TPR_16; pfam13432 380394004314 Maf-like protein; Region: Maf; pfam02545 380394004315 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 380394004316 active site 380394004317 dimer interface [polypeptide binding]; other site 380394004318 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 380394004319 Phosphoenolpyruvate carboxylase; Region: PEPcase; cl17418 380394004320 bacterial Hfq-like; Region: Hfq; cd01716 380394004321 hexamer interface [polypeptide binding]; other site 380394004322 Sm1 motif; other site 380394004323 RNA binding site [nucleotide binding]; other site 380394004324 Sm2 motif; other site 380394004325 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 380394004326 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 380394004327 HflX GTPase family; Region: HflX; cd01878 380394004328 G1 box; other site 380394004329 GTP/Mg2+ binding site [chemical binding]; other site 380394004330 Switch I region; other site 380394004331 G2 box; other site 380394004332 G3 box; other site 380394004333 Switch II region; other site 380394004334 G4 box; other site 380394004335 G5 box; other site 380394004336 Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404 380394004337 HflK protein; Region: hflK; TIGR01933 380394004338 Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405 380394004339 HflC protein; Region: hflC; TIGR01932 380394004340 Histidyl-tRNA synthetase; Region: tRNA-synt_His; pfam13393 380394004341 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 380394004342 dimer interface [polypeptide binding]; other site 380394004343 motif 1; other site 380394004344 active site 380394004345 motif 2; other site 380394004346 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 380394004347 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 380394004348 GDP-binding site [chemical binding]; other site 380394004349 ACT binding site; other site 380394004350 IMP binding site; other site 380394004351 ribonuclease R; Region: RNase_R; TIGR02063 380394004352 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 380394004353 RNB domain; Region: RNB; pfam00773 380394004354 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 380394004355 RNA binding site [nucleotide binding]; other site 380394004356 polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707 380394004357 dihydrolipoamide dehydrogenase; Validated; Region: PRK06292 380394004358 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 380394004359 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 380394004360 Predicted nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA [General function prediction only]; Region: CinA; COG1058 380394004361 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 380394004362 putative MPT binding site; other site 380394004363 Transposase; Region: DEDD_Tnp_IS110; pfam01548 380394004364 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 380394004365 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 380394004366 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 380394004367 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 380394004368 active site 380394004369 substrate binding site [chemical binding]; other site 380394004370 cosubstrate binding site; other site 380394004371 catalytic site [active] 380394004372 Transposase; Region: DEDD_Tnp_IS110; pfam01548 380394004373 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 380394004374 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 380394004375 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 380394004376 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 380394004377 active site 380394004378 substrate binding site [chemical binding]; other site 380394004379 cosubstrate binding site; other site 380394004380 catalytic site [active] 380394004381 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 380394004382 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 380394004383 dimerization interface [polypeptide binding]; other site 380394004384 putative ATP binding site [chemical binding]; other site 380394004385 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 380394004386 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 380394004387 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 380394004388 ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593 380394004389 DnaA regulatory inactivator Hda; Region: DnaA_homol_Hda; TIGR03420 380394004390 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 380394004391 Uncharacterized ACR, COG1399; Region: DUF177; cl00616 380394004392 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 380394004393 putative phosphate acyltransferase; Provisional; Region: PRK05331 380394004394 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 380394004395 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 380394004396 dimer interface [polypeptide binding]; other site 380394004397 active site 380394004398 CoA binding pocket [chemical binding]; other site 380394004399 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 380394004400 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 380394004401 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 380394004402 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 380394004403 NAD(P) binding site [chemical binding]; other site 380394004404 homotetramer interface [polypeptide binding]; other site 380394004405 homodimer interface [polypeptide binding]; other site 380394004406 active site 380394004407 acyl carrier protein; Provisional; Region: acpP; PRK00982 380394004408 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 380394004409 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 380394004410 dimer interface [polypeptide binding]; other site 380394004411 active site 380394004412 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 380394004413 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 380394004414 pyridoxal 5'-phosphate binding site [chemical binding]; other site 380394004415 catalytic residue [active] 380394004416 YceG-like family; Region: YceG; pfam02618 380394004417 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 380394004418 dimerization interface [polypeptide binding]; other site 380394004419 thymidylate kinase; Validated; Region: tmk; PRK00698 380394004420 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 380394004421 TMP-binding site; other site 380394004422 ATP-binding site [chemical binding]; other site 380394004423 DNA polymerase III, delta' subunit; Region: holB; TIGR00678 380394004424 DNA polymerase III subunit delta'; Validated; Region: PRK08485 380394004425 PilZ domain; Region: PilZ; cl01260 380394004426 DNA polymerase III subunits gamma and tau; Validated; Region: PRK07994 380394004427 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 380394004428 Walker A motif; other site 380394004429 ATP binding site [chemical binding]; other site 380394004430 Walker B motif; other site 380394004431 arginine finger; other site 380394004432 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 380394004433 hypothetical protein; Validated; Region: PRK00153 380394004434 recombination protein RecR; Reviewed; Region: recR; PRK00076 380394004435 RecR protein; Region: RecR; pfam02132 380394004436 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 380394004437 putative active site [active] 380394004438 putative metal-binding site [ion binding]; other site 380394004439 tetramer interface [polypeptide binding]; other site 380394004440 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 380394004441 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 380394004442 putative ATP binding site [chemical binding]; other site 380394004443 putative substrate binding site [chemical binding]; other site 380394004444 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 380394004445 adenosylmethionine-8-amino-7-oxononanoate transaminase; Region: bioA; TIGR00508 380394004446 inhibitor-cofactor binding pocket; inhibition site 380394004447 pyridoxal 5'-phosphate binding site [chemical binding]; other site 380394004448 catalytic residue [active] 380394004449 FOG: CBS domain [General function prediction only]; Region: COG0517 380394004450 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 380394004451 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 380394004452 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 380394004453 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 380394004454 ATP binding site [chemical binding]; other site 380394004455 Mg2+ binding site [ion binding]; other site 380394004456 G-X-G motif; other site 380394004457 MutL_Trans_MutL: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to Escherichia coli MutL. EcMutL belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second...; Region: MutL_Trans_MutL; cd03482 380394004458 ATP binding site [chemical binding]; other site 380394004459 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 380394004460 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 380394004461 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cd02019 380394004462 active site 380394004463 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 380394004464 active site 380394004465 multimer interface [polypeptide binding]; other site 380394004466 Predicted Fe-S-cluster redox enzyme [General function prediction only]; Region: COG0820 380394004467 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 380394004468 FeS/SAM binding site; other site 380394004469 TPR repeat; Region: TPR_11; pfam13414 380394004470 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 380394004471 binding surface 380394004472 TPR motif; other site 380394004473 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 380394004474 binding surface 380394004475 TPR motif; other site 380394004476 Tetratricopeptide repeat; Region: TPR_16; pfam13432 380394004477 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 380394004478 non-specific DNA binding site [nucleotide binding]; other site 380394004479 salt bridge; other site 380394004480 sequence-specific DNA binding site [nucleotide binding]; other site 380394004481 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 380394004482 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 380394004483 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 380394004484 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 380394004485 histidyl-tRNA synthetase; Region: hisS; TIGR00442 380394004486 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 380394004487 dimer interface [polypeptide binding]; other site 380394004488 motif 1; other site 380394004489 active site 380394004490 motif 2; other site 380394004491 motif 3; other site 380394004492 HGTP anticodon binding domain, as found at the C-terminus of histidyl, glycyl, threonyl and prolyl tRNA synthetases, which are classified as a group of class II aminoacyl-tRNA synthetases (aaRS). In aaRSs, the anticodon binding domain is responsible for...; Region: HGTP_anticodon; cl00266 380394004493 anticodon binding site; other site 380394004494 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2976 380394004495 outer membrane assembly lipoprotein YfgL; Region: assembly_YfgL; TIGR03300 380394004496 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 380394004497 Trp docking motif [polypeptide binding]; other site 380394004498 active site 380394004499 GTP-binding protein Der; Reviewed; Region: PRK00093 380394004500 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 380394004501 G1 box; other site 380394004502 GTP/Mg2+ binding site [chemical binding]; other site 380394004503 Switch I region; other site 380394004504 G2 box; other site 380394004505 Switch II region; other site 380394004506 G3 box; other site 380394004507 G4 box; other site 380394004508 G5 box; other site 380394004509 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 380394004510 G1 box; other site 380394004511 GTP/Mg2+ binding site [chemical binding]; other site 380394004512 Switch I region; other site 380394004513 G2 box; other site 380394004514 G3 box; other site 380394004515 Switch II region; other site 380394004516 G4 box; other site 380394004517 G5 box; other site 380394004518 PBP superfamily domain; Region: PBP_like_2; cl17296 380394004519 phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138 380394004520 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 380394004521 dimer interface [polypeptide binding]; other site 380394004522 conserved gate region; other site 380394004523 putative PBP binding loops; other site 380394004524 ABC-ATPase subunit interface; other site 380394004525 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 380394004526 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 380394004527 dimer interface [polypeptide binding]; other site 380394004528 conserved gate region; other site 380394004529 putative PBP binding loops; other site 380394004530 ABC-ATPase subunit interface; other site 380394004531 Uncharacterized conserved protein (DUF2249); Region: DUF2249; cl17719 380394004532 Hemerythrin-like domain; Region: Hr-like; cd12108 380394004533 Fe binding site [ion binding]; other site 380394004534 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 380394004535 hypothetical protein; Provisional; Region: PRK10621 380394004536 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 380394004537 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 380394004538 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 380394004539 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 380394004540 HlyD family secretion protein; Region: HlyD_3; pfam13437 380394004541 Outer membrane efflux protein; Region: OEP; pfam02321 380394004542 Outer membrane efflux protein; Region: OEP; pfam02321 380394004543 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 380394004544 substrate binding site [chemical binding]; other site 380394004545 Uncharacterized protein domain (DUF2202); Region: DUF2202; pfam09968 380394004546 Uncharacterized family of ferritin-like proteins found in archaea and bacteria; Region: Ferritin_like_AB2; cd01048 380394004547 diiron binding motif [ion binding]; other site 380394004548 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 380394004549 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 380394004550 metal binding site 2 [ion binding]; metal-binding site 380394004551 putative DNA binding helix; other site 380394004552 metal binding site 1 [ion binding]; metal-binding site 380394004553 structural Zn2+ binding site [ion binding]; other site 380394004554 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 380394004555 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 380394004556 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911 380394004557 Family of unknown function (DUF490); Region: DUF490; pfam04357 380394004558 Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729 380394004559 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 380394004560 Surface antigen; Region: Bac_surface_Ag; pfam01103 380394004561 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429 380394004562 siderophore transporter, RhtX/FptX family; Region: sider_RhtX_FptX; TIGR02718 380394004563 muropeptide transporter; Validated; Region: ampG; cl17669 380394004564 Cytochrome c; Region: Cytochrom_C; cl11414 380394004565 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 380394004566 The Delta12 Fatty Acid Desaturase (Delta12-FADS)-like CD includes the integral-membrane enzymes, delta-12 acyl-lipid desaturases, oleate 12-hydroxylases, omega3 and omega6 fatty acid desaturases, and other related proteins, found in a wide range of...; Region: Delta12-FADS-like; cd03507 380394004567 putative di-iron ligands [ion binding]; other site 380394004568 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 380394004569 UDP glucuronic acid epimerase, extended (e) SDRs; Region: UDP_GE_SDE_e; cd05253 380394004570 putative NAD(P) binding site [chemical binding]; other site 380394004571 active site 380394004572 putative substrate binding site [chemical binding]; other site 380394004573 ADP-L-glycero-D-mannoheptose 6-epimerase (GME), extended (e) SDRs; Region: ADP_GME_SDR_e; cd05248 380394004574 ADP-L-glycero-D-manno-heptose-6-epimerase; Region: heptose_epim; TIGR02197 380394004575 NADP binding site [chemical binding]; other site 380394004576 homopentamer interface [polypeptide binding]; other site 380394004577 substrate binding site [chemical binding]; other site 380394004578 active site 380394004579 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 380394004580 putative cation:proton antiport protein; Provisional; Region: PRK10669 380394004581 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 380394004582 TrkA-N domain; Region: TrkA_N; pfam02254 380394004583 TrkA-C domain; Region: TrkA_C; pfam02080 380394004584 acetyl-CoA synthetase; Provisional; Region: PRK00174 380394004585 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 380394004586 active site 380394004587 CoA binding site [chemical binding]; other site 380394004588 acyl-activating enzyme (AAE) consensus motif; other site 380394004589 AMP binding site [chemical binding]; other site 380394004590 acetate binding site [chemical binding]; other site 380394004591 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 380394004592 Clp amino terminal domain; Region: Clp_N; pfam02861 380394004593 Clp amino terminal domain; Region: Clp_N; pfam02861 380394004594 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 380394004595 Walker A motif; other site 380394004596 ATP binding site [chemical binding]; other site 380394004597 Walker B motif; other site 380394004598 arginine finger; other site 380394004599 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 380394004600 Walker A motif; other site 380394004601 ATP binding site [chemical binding]; other site 380394004602 Walker B motif; other site 380394004603 arginine finger; other site 380394004604 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 380394004605 MFS_1 like family; Region: MFS_1_like; pfam12832 380394004606 Major Facilitator Superfamily; Region: MFS_1; pfam07690 380394004607 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 380394004608 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 380394004609 Tetramer interface [polypeptide binding]; other site 380394004610 active site 380394004611 FMN-binding site [chemical binding]; other site 380394004612 putative GTP cyclohydrolase; Provisional; Region: PRK13674 380394004613 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 380394004614 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 380394004615 TPP-binding site; other site 380394004616 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 380394004617 PYR/PP interface [polypeptide binding]; other site 380394004618 dimer interface [polypeptide binding]; other site 380394004619 TPP binding site [chemical binding]; other site 380394004620 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 380394004621 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 380394004622 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 380394004623 substrate binding pocket [chemical binding]; other site 380394004624 chain length determination region; other site 380394004625 substrate-Mg2+ binding site; other site 380394004626 catalytic residues [active] 380394004627 aspartate-rich region 1; other site 380394004628 active site lid residues [active] 380394004629 aspartate-rich region 2; other site 380394004630 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 380394004631 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 380394004632 Major Facilitator Superfamily; Region: MFS_1; pfam07690 380394004633 putative substrate translocation pore; other site 380394004634 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 380394004635 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 380394004636 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 380394004637 catalytic residues [active] 380394004638 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 380394004639 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 380394004640 generic binding surface II; other site 380394004641 generic binding surface I; other site 380394004642 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 380394004643 active site 380394004644 PQQ-like domain; Region: PQQ_2; pfam13360 380394004645 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 380394004646 Trp docking motif [polypeptide binding]; other site 380394004647 active site 380394004648 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 380394004649 active site 380394004650 Domain of unknown function (DUF4168); Region: DUF4168; pfam13767 380394004651 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 380394004652 substrate binding site [chemical binding]; other site 380394004653 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 380394004654 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 380394004655 putative active site [active] 380394004656 putative metal binding site [ion binding]; other site 380394004657 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 380394004658 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 380394004659 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 380394004660 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 380394004661 motif II; other site 380394004662 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 380394004663 2-isopropylmalate synthase; Validated; Region: PRK03739 380394004664 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 380394004665 active site 380394004666 catalytic residues [active] 380394004667 metal binding site [ion binding]; metal-binding site 380394004668 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 380394004669 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 380394004670 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 380394004671 putative DNA binding site [nucleotide binding]; other site 380394004672 putative Zn2+ binding site [ion binding]; other site 380394004673 AsnC family; Region: AsnC_trans_reg; pfam01037 380394004674 Tellurite-resistance/Dicarboxylate Transporter (TDT) family includes sulfite sensitivity protein (sulfite efflux pump; SSU1); Region: TDT_SSU1; cd09318 380394004675 Tellurite resistance protein and related permeases [Inorganic ion transport and metabolism]; Region: TehA; COG1275 380394004676 gating phenylalanine in ion channel; other site 380394004677 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 380394004678 aminoethylphosphonate catabolism associated LysR family transcriptional regulator; Region: phn_lysR; TIGR03339 380394004679 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 380394004680 dimerization interface [polypeptide binding]; other site 380394004681 3,4-dihydroxy-2-butanone 4-phosphate synthase; Provisional; Region: ribB; PRK03353 380394004682 3,4-dihydroxy-2-butanone 4-phosphate synthase [Coenzyme metabolism]; Region: RibB; COG0108 380394004683 DNA-binding transcriptional activator SdiA; Provisional; Region: PRK10188 380394004684 Autoinducer binding domain; Region: Autoind_bind; pfam03472 380394004685 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 380394004686 DNA binding residues [nucleotide binding] 380394004687 dimerization interface [polypeptide binding]; other site 380394004688 Autoinducer synthetase; Region: Autoind_synth; cl17404 380394004689 EVE domain; Region: EVE; cl00728 380394004690 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 380394004691 active site 380394004692 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267 380394004693 ABC transporter signature motif; other site 380394004694 Walker B; other site 380394004695 D-loop; other site 380394004696 H-loop/switch region; other site 380394004697 Histone acetyltransferase HPA2 and related acetyltransferases [Transcription / General function prediction only]; Region: WecD; COG0454 380394004698 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 380394004699 Coenzyme A binding pocket [chemical binding]; other site 380394004700 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 380394004701 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 380394004702 conserved cys residue [active] 380394004703 Putative FMN-binding domain; Region: FMN_bind_2; pfam04299 380394004704 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 380394004705 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 380394004706 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_4; cd07822 380394004707 putative hydrophobic ligand binding site [chemical binding]; other site 380394004708 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 380394004709 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 380394004710 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 380394004711 MarR family; Region: MarR_2; pfam12802 380394004712 Uncharacterized conserved protein [Function unknown]; Region: COG2128 380394004713 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 380394004714 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 380394004715 Coenzyme A binding pocket [chemical binding]; other site 380394004716 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 380394004717 Uncharacterized conserved protein [Function unknown]; Region: COG0393 380394004718 Uncharacterized conserved protein [Function unknown]; Region: COG0393 380394004719 Domain of unknown function (DUF4156); Region: DUF4156; pfam13698 380394004720 Putative heavy-metal-binding; Region: YbjQ_1; cl00426 380394004721 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 380394004722 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 380394004723 metal-binding site [ion binding] 380394004724 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 380394004725 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 380394004726 metal-binding site [ion binding] 380394004727 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 380394004728 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 380394004729 aspartate aminotransferase; Provisional; Region: PRK05764 380394004730 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 380394004731 pyridoxal 5'-phosphate binding site [chemical binding]; other site 380394004732 homodimer interface [polypeptide binding]; other site 380394004733 catalytic residue [active] 380394004734 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 380394004735 ATP-grasp domain; Region: ATP-grasp; pfam02222 380394004736 Predicted 6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; Region: Gnd; COG1023 380394004737 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 380394004738 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 380394004739 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 380394004740 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 380394004741 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 380394004742 dimerization interface [polypeptide binding]; other site 380394004743 putative DNA binding site [nucleotide binding]; other site 380394004744 putative Zn2+ binding site [ion binding]; other site 380394004745 tRNA dihydrouridine synthase A; Region: yjbN; TIGR00742 380394004746 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 380394004747 FMN binding site [chemical binding]; other site 380394004748 active site 380394004749 catalytic residues [active] 380394004750 substrate binding site [chemical binding]; other site 380394004751 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 380394004752 CAP-like domain; other site 380394004753 DNA gyrase/topoisomerase IV, subunit A; Region: DNA_topoisoIV; pfam00521 380394004754 active site 380394004755 primary dimer interface [polypeptide binding]; other site 380394004756 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 380394004757 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 380394004758 ATP binding site [chemical binding]; other site 380394004759 Mg2+ binding site [ion binding]; other site 380394004760 G-X-G motif; other site 380394004761 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 380394004762 anchoring element; other site 380394004763 dimer interface [polypeptide binding]; other site 380394004764 ATP binding site [chemical binding]; other site 380394004765 TOPRIM_TopoIIA_like: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to Saccharomyces cerevisiae Topoisomerase II. TopoIIA enzymes cut both strands...; Region: TOPRIM_TopoIIA_like; cd01030 380394004766 active site 380394004767 putative metal-binding site [ion binding]; other site 380394004768 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 380394004769 sensor protein QseC; Provisional; Region: PRK10337 380394004770 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 380394004771 dimer interface [polypeptide binding]; other site 380394004772 phosphorylation site [posttranslational modification] 380394004773 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 380394004774 ATP binding site [chemical binding]; other site 380394004775 Mg2+ binding site [ion binding]; other site 380394004776 G-X-G motif; other site 380394004777 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 380394004778 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 380394004779 active site 380394004780 phosphorylation site [posttranslational modification] 380394004781 intermolecular recognition site; other site 380394004782 dimerization interface [polypeptide binding]; other site 380394004783 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 380394004784 DNA binding site [nucleotide binding] 380394004785 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 380394004786 Uncharacterized conserved protein [Function unknown]; Region: COG3391 380394004787 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 380394004788 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 380394004789 HlyD family secretion protein; Region: HlyD_3; pfam13437 380394004790 Outer membrane efflux protein; Region: OEP; pfam02321 380394004791 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 380394004792 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 380394004793 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 380394004794 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 380394004795 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 380394004796 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 380394004797 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cl00365 380394004798 F0F1 ATP synthase subunit beta; Provisional; Region: PRK12597 380394004799 EamA-like transporter family; Region: EamA; pfam00892 380394004800 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 380394004801 putative phosphoketolase; Provisional; Region: PRK05261 380394004802 Thiamine pyrophosphate (TPP) family, Phosphoketolase (PK) subfamily, TPP-binding module; PK catalyzes the conversion of D-xylulose 5-phosphate and phosphate to acetyl phosphate, D-glyceraldehyde-3-phosphate and H2O. This enzyme requires divalent...; Region: TPP_PK; cd02011 380394004803 TPP-binding site; other site 380394004804 XFP C-terminal domain; Region: XFP_C; pfam09363 380394004805 Protein of unknown function, DUF481; Region: DUF481; cl01213 380394004806 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 380394004807 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 380394004808 Protein export membrane protein; Region: SecD_SecF; pfam02355 380394004809 SecD export protein N-terminal TM region; Region: SecD-TM1; pfam13721 380394004810 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 380394004811 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 380394004812 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 380394004813 Preprotein translocase subunit; Region: YajC; pfam02699 380394004814 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 380394004815 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 380394004816 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 380394004817 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 380394004818 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 380394004819 Domain of unknown function DUF21; Region: DUF21; pfam01595 380394004820 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 380394004821 Transporter associated domain; Region: CorC_HlyC; smart01091 380394004822 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 380394004823 O-succinylhomoserine sulfhydrylase; Validated; Region: PRK08133 380394004824 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 380394004825 homodimer interface [polypeptide binding]; other site 380394004826 substrate-cofactor binding pocket; other site 380394004827 pyridoxal 5'-phosphate binding site [chemical binding]; other site 380394004828 catalytic residue [active] 380394004829 amidophosphoribosyltransferase; Provisional; Region: PRK09123 380394004830 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 380394004831 active site 380394004832 tetramer interface [polypeptide binding]; other site 380394004833 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 380394004834 active site 380394004835 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 380394004836 Colicin V production protein; Region: Colicin_V; pfam02674 380394004837 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 380394004838 Tetraacyldisaccharide-1-P 4'-kinase; Region: LpxK; cl03652 380394004839 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 380394004840 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 380394004841 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 380394004842 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 380394004843 substrate binding site [chemical binding]; other site 380394004844 active site 380394004845 catalytic residues [active] 380394004846 heterodimer interface [polypeptide binding]; other site 380394004847 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 380394004848 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 380394004849 pyridoxal 5'-phosphate binding site [chemical binding]; other site 380394004850 catalytic residue [active] 380394004851 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 380394004852 active site 380394004853 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 380394004854 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 380394004855 dimerization interface 3.5A [polypeptide binding]; other site 380394004856 active site 380394004857 FimV N-terminal domain; Region: FimV_core; TIGR03505 380394004858 FimV C-terminal domain; Region: FimV_Cterm; TIGR03504 380394004859 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 380394004860 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 380394004861 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 380394004862 tartrate dehydrogenase; Region: TTC; TIGR02089 380394004863 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 380394004864 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 380394004865 GTP binding site; other site 380394004866 Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116 380394004867 Walker A motif; other site 380394004868 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 380394004869 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 380394004870 dimer interface [polypeptide binding]; other site 380394004871 putative functional site; other site 380394004872 putative MPT binding site; other site 380394004873 Catalytic domain of EDTA-resistant nuclease Nuc from Salmonella typhimurium and similar proteins; Region: PLDc_Nuc; cd09170 380394004874 PLD-like domain; Region: PLDc_2; pfam13091 380394004875 putative active site [active] 380394004876 catalytic site [active] 380394004877 Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018 380394004878 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 380394004879 oligomer interface [polypeptide binding]; other site 380394004880 tandem repeat interface [polypeptide binding]; other site 380394004881 active site residues [active] 380394004882 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 380394004883 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 380394004884 tandem repeat interface [polypeptide binding]; other site 380394004885 oligomer interface [polypeptide binding]; other site 380394004886 active site residues [active] 380394004887 maltooligosyl trehalose synthase; Provisional; Region: PRK14511 380394004888 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 380394004889 Alpha amylase catalytic domain found in maltooligosyl trehalose synthase (MTSase); Region: AmyAc_MTSase; cd11336 380394004890 active site 380394004891 catalytic site [active] 380394004892 N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853 380394004893 malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402 380394004894 Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325 380394004895 catalytic site [active] 380394004896 active site 380394004897 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 380394004898 Trehalose phosphorylase (TP) reversibly catalyzes trehalose synthesis and degradation from alpha-glucose-1-phosphate (alpha-Glc-1-P) and glucose. The catalyzing activity includes the phosphorolysis of trehalose, which produce alpha-Glc-1-P and glucose; Region: GT1_Trehalose_phosphorylase; cd03792 380394004899 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 380394004900 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 380394004901 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 380394004902 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 380394004903 alpha-crystallin domain (ACD) found in alpha-crystallin-type small heat shock proteins, and a similar domain found in p23 (a cochaperone for Hsp90) and in other p23-like proteins; Region: alpha-crystallin-Hsps_p23-like; cl00175 380394004904 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 380394004905 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD2; cd08298 380394004906 putative NAD(P) binding site [chemical binding]; other site 380394004907 putative substrate binding site [chemical binding]; other site 380394004908 catalytic Zn binding site [ion binding]; other site 380394004909 structural Zn binding site [ion binding]; other site 380394004910 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 380394004911 Peptidase family M48; Region: Peptidase_M48; cl12018 380394004912 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 380394004913 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 380394004914 putative substrate translocation pore; other site 380394004915 Phosphoinositide 3-kinase (PI3K)-like family, catalytic domain; The PI3K-like catalytic domain family is part of a larger superfamily that includes the catalytic domains of other kinases such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: PI3Kc_like; cl00119 380394004916 thiazole/oxazole-forming peptide maturase, SagD family component; Region: TOMM_cyclo_SagD; TIGR03604 380394004917 YcaO-like family; Region: YcaO; pfam02624 380394004918 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 380394004919 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 380394004920 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 380394004921 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 380394004922 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 380394004923 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 380394004924 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 380394004925 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 380394004926 active site 380394004927 NTP binding site [chemical binding]; other site 380394004928 metal binding triad [ion binding]; metal-binding site 380394004929 antibiotic binding site [chemical binding]; other site 380394004930 Sulfotransferase family; Region: Sulfotransfer_2; pfam03567 380394004931 ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; pfam12762 380394004932 Outer membrane efflux protein; Region: OEP; pfam02321 380394004933 Outer membrane efflux protein; Region: OEP; pfam02321 380394004934 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 380394004935 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 380394004936 HlyD family secretion protein; Region: HlyD_3; pfam13437 380394004937 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 380394004938 Protein export membrane protein; Region: SecD_SecF; cl14618 380394004939 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 380394004940 AAA domain; Region: AAA_23; pfam13476 380394004941 Walker A/P-loop; other site 380394004942 ATP binding site [chemical binding]; other site 380394004943 ABC transporter; Region: ABC_tran; pfam00005 380394004944 Q-loop/lid; other site 380394004945 ABC transporter signature motif; other site 380394004946 Walker B; other site 380394004947 D-loop; other site 380394004948 H-loop/switch region; other site 380394004949 Domain of unknown function (DUF4338); Region: DUF4338; pfam14236 380394004950 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 380394004951 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880 380394004952 SCP-2 sterol transfer family; Region: SCP2; cl01225 380394004953 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 380394004954 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 380394004955 GatB domain; Region: GatB_Yqey; smart00845 380394004956 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 380394004957 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 380394004958 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 380394004959 VacJ like lipoprotein; Region: VacJ; cl01073 380394004960 hopanoid biosynthesis associated membrane protein HpnM; Region: HpnM; TIGR03481 380394004961 hopanoid biosynthesis associated radical SAM protein HpnH; Region: HpnH; TIGR03470 380394004962 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 380394004963 FeS/SAM binding site; other site 380394004964 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 380394004965 Domain of unknown function (DUF3463); Region: DUF3463; pfam11946 380394004966 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 380394004967 dinuclear metal binding motif [ion binding]; other site 380394004968 putative membrane protein; Region: HpnL; TIGR03476 380394004969 hopanoid biosynthesis associated RND transporter like protein HpnN; Region: HpnN; TIGR03480 380394004970 hopanoid biosynthesis associated protein HpnK and similar proteins; Region: YdjC_HpnK_like; cd10804 380394004971 putative active site [active] 380394004972 YdjC motif; other site 380394004973 Mg binding site [ion binding]; other site 380394004974 putative homodimer interface [polypeptide binding]; other site 380394004975 hopanoid biosynthesis associated radical SAM protein HpnJ; Region: HpnJ; TIGR03471 380394004976 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 380394004977 B12 binding site [chemical binding]; other site 380394004978 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 380394004979 FeS/SAM binding site; other site 380394004980 hopanoid biosynthesis associated glycosyl transferase protein HpnI; Region: HpnI; TIGR03472 380394004981 Glucosylceramide synthase catalyzes the first glycosylation step of glycosphingolipid synthesis; Region: Glucosylceramide_synthase; cd02520 380394004982 ligand binding site; other site 380394004983 hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466 380394004984 uncharacterized subgroup of aldehyde reductase and flavonoid reductase related proteins, extended (e) SDRs; Region: AR_FR_like_1_SDR_e; cd05228 380394004985 putative NADP binding site [chemical binding]; other site 380394004986 putative substrate binding site [chemical binding]; other site 380394004987 active site 380394004988 hopanoid-associated phosphorylase; Region: HpnG; TIGR03468 380394004989 Squalene cyclase (SQCY) domain subgroup 1; found in class II terpene cyclases that have an alpha 6 - alpha 6 barrel fold. Squalene cyclase (SQCY) and 2,3-oxidosqualene cyclase (OSQCY) are integral membrane proteins that catalyze a cationic cyclization...; Region: SQCY_1; cd02892 380394004990 squalene-hopene cyclase; Region: hopene_cyclase; TIGR01507 380394004991 Active site cavity [active] 380394004992 catalytic acid [active] 380394004993 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 380394004994 active site lid residues [active] 380394004995 substrate binding pocket [chemical binding]; other site 380394004996 catalytic residues [active] 380394004997 substrate-Mg2+ binding site; other site 380394004998 aspartate-rich region 1; other site 380394004999 aspartate-rich region 2; other site 380394005000 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 380394005001 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 380394005002 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 380394005003 preprotein translocase subunit SecB; Validated; Region: PRK05751 380394005004 SecA binding site; other site 380394005005 Preprotein binding site; other site 380394005006 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 380394005007 oligomeric interface; other site 380394005008 putative active site [active] 380394005009 homodimer interface [polypeptide binding]; other site 380394005010 Virulence-associated protein and related proteins [Function unknown]; Region: VagC; COG4456 380394005011 Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II-like; Region: ALDH_ACDHII-AcoD; cd07116 380394005012 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 380394005013 NAD(P) binding site [chemical binding]; other site 380394005014 catalytic residues [active] 380394005015 prolyl-tRNA synthetase; Provisional; Region: PRK09194 380394005016 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 380394005017 dimer interface [polypeptide binding]; other site 380394005018 motif 1; other site 380394005019 active site 380394005020 motif 2; other site 380394005021 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 380394005022 putative deacylase active site [active] 380394005023 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 380394005024 active site 380394005025 motif 3; other site 380394005026 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 380394005027 anticodon binding site; other site 380394005028 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 380394005029 Ligand Binding Site [chemical binding]; other site 380394005030 Protein of unknown function (DUF330); Region: DUF330; cl01135 380394005031 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 380394005032 mce related protein; Region: MCE; pfam02470 380394005033 Protein-L-isoaspartate carboxylmethyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: Pcm; COG2518 380394005034 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 380394005035 S-adenosylmethionine binding site [chemical binding]; other site 380394005036 Isochorismatase family; Region: Isochorismatase; pfam00857 380394005037 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 380394005038 catalytic triad [active] 380394005039 dimer interface [polypeptide binding]; other site 380394005040 conserved cis-peptide bond; other site 380394005041 Predicted protease with the C-terminal PDZ domain [General function prediction only]; Region: COG3975 380394005042 M61 glycyl aminopeptidase; Region: Peptidase_M61; pfam05299 380394005043 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 380394005044 protein binding site [polypeptide binding]; other site 380394005045 Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382 380394005046 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 380394005047 putative active site [active] 380394005048 metal binding site [ion binding]; metal-binding site 380394005049 homodimer binding site [polypeptide binding]; other site 380394005050 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 380394005051 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 380394005052 Cell division protein ZapA; Region: ZapA; pfam05164 380394005053 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 380394005054 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 380394005055 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 380394005056 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 380394005057 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 380394005058 5S rRNA interface [nucleotide binding]; other site 380394005059 CTC domain interface [polypeptide binding]; other site 380394005060 L16 interface [polypeptide binding]; other site 380394005061 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 380394005062 putative active site [active] 380394005063 catalytic residue [active] 380394005064 GTP-binding protein YchF; Reviewed; Region: PRK09601 380394005065 YchF GTPase; Region: YchF; cd01900 380394005066 G1 box; other site 380394005067 GTP/Mg2+ binding site [chemical binding]; other site 380394005068 Switch I region; other site 380394005069 G2 box; other site 380394005070 Switch II region; other site 380394005071 G3 box; other site 380394005072 G4 box; other site 380394005073 G5 box; other site 380394005074 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 380394005075 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 380394005076 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 380394005077 non-specific DNA binding site [nucleotide binding]; other site 380394005078 salt bridge; other site 380394005079 sequence-specific DNA binding site [nucleotide binding]; other site 380394005080 Cupin domain; Region: Cupin_2; pfam07883 380394005081 hydrogenase 4 subunit B; Validated; Region: PRK06521 380394005082 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 380394005083 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 380394005084 Hydrogenase 4 membrane component (E) [Energy production and conversion]; Region: HyfE; cl17899 380394005085 hydrogenase 4 subunit F; Validated; Region: PRK06458 380394005086 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 380394005087 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; pfam00329 380394005088 Ni,Fe-hydrogenase III large subunit [Energy production and conversion]; Region: HycE; COG3261 380394005089 NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338 380394005090 Ni,Fe-hydrogenase III small subunit [Energy production and conversion]; Region: COG3260 380394005091 S-AdoMet dependent tetrapyrrole methylases; Region: TP_methylase; cl00304 380394005092 homodimer interface [polypeptide binding]; other site 380394005093 ribulose bisphosphate carboxylase; Provisional; Region: PRK13475 380394005094 Ribulose bisphosphate carboxylase large chain, Form II; Region: RuBisCO_large_II; cd08211 380394005095 dimer interface [polypeptide binding]; other site 380394005096 active site 380394005097 catalytic residue [active] 380394005098 metal binding site [ion binding]; metal-binding site 380394005099 MoxR-like ATPases [General function prediction only]; Region: COG0714 380394005100 AAA domain (dynein-related subfamily); Region: AAA_5; pfam07728 380394005101 Walker A motif; other site 380394005102 ATP binding site [chemical binding]; other site 380394005103 Walker B motif; other site 380394005104 CbbQ/NirQ/NorQ C-terminal; Region: CbbQ_C; pfam08406 380394005105 norD type: Denitrifying bacteria contain both membrane bound and periplasmic nitrate reductases. Denitrification plays a major role in completing the nitrogen cycle by converting nitrate or nitrite to nitrogen gas. The pathway for microbial...; Region: vWA_norD_type; cd01454 380394005106 Transcriptional regulator [Transcription]; Region: LysR; COG0583 380394005107 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 380394005108 The C-terminal substrate binding of LysR-type transcriptional regulator (CbbR) of RubisCO operon, which is involved in the carbon dioxide fixation, contains the type 2 periplasmic binding fold; Region: PBP2_CbbR_RubisCO_like; cd08419 380394005109 putative dimerization interface [polypeptide binding]; other site 380394005110 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 380394005111 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 380394005112 PhnA protein; Region: PhnA; pfam03831 380394005113 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 380394005114 Domain of Unknown Function with PDB structure (DUF3857); Region: DUF3857; pfam12969 380394005115 Transglutaminase-like superfamily; Region: Transglut_core; cl17362 380394005116 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 380394005117 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 380394005118 HlyD family secretion protein; Region: HlyD_3; pfam13437 380394005119 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 380394005120 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39C; cd02419 380394005121 putative active site [active] 380394005122 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 380394005123 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 380394005124 Walker A/P-loop; other site 380394005125 ATP binding site [chemical binding]; other site 380394005126 Q-loop/lid; other site 380394005127 ABC transporter signature motif; other site 380394005128 Walker B; other site 380394005129 D-loop; other site 380394005130 H-loop/switch region; other site 380394005131 Outer membrane efflux protein; Region: OEP; pfam02321 380394005132 Outer membrane efflux protein; Region: OEP; pfam02321 380394005133 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 380394005134 putative active site [active] 380394005135 putative metal binding site [ion binding]; other site 380394005136 Cna protein B-type domain; Region: Cna_B_2; pfam13715 380394005137 Putative glycosyl hydrolase domain; Region: DUF4015; pfam13200 380394005138 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 380394005139 Beta-lactamase; Region: Beta-lactamase; pfam00144 380394005140 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671 380394005141 putative active site [active] 380394005142 Ap4A binding site [chemical binding]; other site 380394005143 nudix motif; other site 380394005144 putative metal binding site [ion binding]; other site 380394005145 Contains a crystal structure of the Nudix hydrolase from Nitrosomonas europaea, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_2; cd03675 380394005146 nudix motif; other site 380394005147 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 380394005148 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 380394005149 RNA binding surface [nucleotide binding]; other site 380394005150 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 380394005151 active site 380394005152 uracil binding [chemical binding]; other site 380394005153 Peptidylarginine deiminase and related enzymes [Amino acid transport and metabolism]; Region: COG2957; cl01113 380394005154 Porphyromonas-type peptidyl-arginine deiminase; Region: PAD_porph; pfam04371 380394005155 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 380394005156 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 380394005157 molybdopterin cofactor binding site; other site 380394005158 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 380394005159 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 380394005160 The MopB_CT_Thiosulfate-R-like CD contains thiosulfate-, sulfur-, and polysulfide-reductases, and other related proteins. Thiosulfate reductase catalyzes the cleavage of sulfur-sulfur bonds in thiosulfate. Polysulfide reductase is a membrane-bound enzyme...; Region: MopB_CT_Thiosulfate-R-like; cd02778 380394005161 putative molybdopterin cofactor binding site; other site 380394005162 Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437 380394005163 4Fe-4S binding domain; Region: Fer4; pfam00037 380394005164 Formate-dependent nitrite reductase, membrane component [Inorganic ion transport and metabolism]; Region: NrfD; COG3301 380394005165 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 380394005166 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 380394005167 Ligand Binding Site [chemical binding]; other site 380394005168 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 380394005169 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 380394005170 putative substrate translocation pore; other site 380394005171 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 380394005172 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 380394005173 MarR family; Region: MarR_2; pfam12802 380394005174 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 380394005175 ATP-dependent DNA helicase Rep; Region: rep; TIGR01074 380394005176 Part of AAA domain; Region: AAA_19; pfam13245 380394005177 Family description; Region: UvrD_C_2; pfam13538 380394005178 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 380394005179 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 380394005180 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 380394005181 Walker A/P-loop; other site 380394005182 ATP binding site [chemical binding]; other site 380394005183 Q-loop/lid; other site 380394005184 ABC transporter signature motif; other site 380394005185 Walker B; other site 380394005186 D-loop; other site 380394005187 H-loop/switch region; other site 380394005188 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 380394005189 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 380394005190 dimer interface [polypeptide binding]; other site 380394005191 conserved gate region; other site 380394005192 putative PBP binding loops; other site 380394005193 ABC-ATPase subunit interface; other site 380394005194 diadenosine tetraphosphatase; Reviewed; Region: apaH; PRK00166 380394005195 Escherichia coli ApaH and related proteins, metallophosphatase domain; Region: MPP_ApaH; cd07422 380394005196 active site 380394005197 metal binding site [ion binding]; metal-binding site 380394005198 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 380394005199 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 380394005200 ATP binding site [chemical binding]; other site 380394005201 putative Mg++ binding site [ion binding]; other site 380394005202 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 380394005203 nucleotide binding region [chemical binding]; other site 380394005204 ATP-binding site [chemical binding]; other site 380394005205 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 380394005206 HRDC domain; Region: HRDC; pfam00570 380394005207 iron donor protein CyaY; Region: FeS_CyaY; TIGR03421 380394005208 putative iron binding site [ion binding]; other site 380394005209 EVE domain; Region: EVE; cl00728 380394005210 Predicted permeases [General function prediction only]; Region: COG0795 380394005211 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 380394005212 Predicted permeases [General function prediction only]; Region: COG0795 380394005213 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 380394005214 multifunctional aminopeptidase A; Provisional; Region: PRK00913 380394005215 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 380394005216 interface (dimer of trimers) [polypeptide binding]; other site 380394005217 Substrate-binding/catalytic site; other site 380394005218 Zn-binding sites [ion binding]; other site 380394005219 DNA polymerase III chi subunit, HolC; Region: DNA_pol3_chi; pfam04364 380394005220 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 380394005221 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 380394005222 active site 380394005223 HIGH motif; other site 380394005224 nucleotide binding site [chemical binding]; other site 380394005225 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 380394005226 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 380394005227 active site 380394005228 KMSKS motif; other site 380394005229 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 380394005230 tRNA binding surface [nucleotide binding]; other site 380394005231 anticodon binding site; other site 380394005232 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 380394005233 pH-dependent sodium/proton antiporter; Reviewed; Region: nhaA; PRK09560 380394005234 Nicotinate-nucleotide pyrophosphorylase [Coenzyme metabolism]; Region: NadC; COG0157 380394005235 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 380394005236 dimerization interface [polypeptide binding]; other site 380394005237 active site 380394005238 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 380394005239 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 380394005240 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 380394005241 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 380394005242 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 380394005243 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 380394005244 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 380394005245 active site 380394005246 FMN binding site [chemical binding]; other site 380394005247 substrate binding site [chemical binding]; other site 380394005248 homotetramer interface [polypeptide binding]; other site 380394005249 catalytic residue [active] 380394005250 Protein of unknown function (DUF805); Region: DUF805; pfam05656 380394005251 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 380394005252 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 380394005253 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 380394005254 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 380394005255 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 380394005256 motif II; other site 380394005257 23S rRNA pseudouridylate synthase C; Provisional; Region: PRK11025 380394005258 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 380394005259 RNA binding surface [nucleotide binding]; other site 380394005260 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 380394005261 active site 380394005262 Ribonucleases G and E [Translation, ribosomal structure and biogenesis]; Region: CafA; COG1530 380394005263 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 380394005264 homodimer interface [polypeptide binding]; other site 380394005265 oligonucleotide binding site [chemical binding]; other site 380394005266 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 380394005267 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 380394005268 active site 380394005269 HIGH motif; other site 380394005270 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 380394005271 KMSKS motif; other site 380394005272 Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963 380394005273 tRNA binding surface [nucleotide binding]; other site 380394005274 anticodon binding site; other site 380394005275 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 380394005276 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 380394005277 active site 380394005278 HIGH motif; other site 380394005279 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 380394005280 active site 380394005281 KMSKS motif; other site 380394005282 Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane]; Region: MrcA; COG5009 380394005283 Transglycosylase; Region: Transgly; pfam00912 380394005284 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 380394005285 Glycoside hydrolase family 15, N-terminal domain; Region: GH15_N; cd07430 380394005286 Domain interface; other site 380394005287 glucan 1,4-alpha-glucosidase; Region: glucan_glucosid; TIGR01535 380394005288 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 380394005289 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 380394005290 glucose 1 dehydrogenase (GlcDH), classical (c) SDRs; Region: GlcDH_SDR_c; cd05358 380394005291 NAD binding site [chemical binding]; other site 380394005292 homodimer interface [polypeptide binding]; other site 380394005293 active site 380394005294 Phosphotransferase enzyme family; Region: APH; pfam01636 380394005295 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 380394005296 active site 380394005297 ATP binding site [chemical binding]; other site 380394005298 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 380394005299 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 380394005300 motif II; other site 380394005301 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 380394005302 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 380394005303 active site 380394005304 phosphorylation site [posttranslational modification] 380394005305 intermolecular recognition site; other site 380394005306 dimerization interface [polypeptide binding]; other site 380394005307 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 380394005308 DNA binding site [nucleotide binding] 380394005309 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 380394005310 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 380394005311 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 380394005312 Ligand Binding Site [chemical binding]; other site 380394005313 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 380394005314 GAF domain; Region: GAF_3; pfam13492 380394005315 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 380394005316 dimer interface [polypeptide binding]; other site 380394005317 phosphorylation site [posttranslational modification] 380394005318 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 380394005319 ATP binding site [chemical binding]; other site 380394005320 Mg2+ binding site [ion binding]; other site 380394005321 G-X-G motif; other site 380394005322 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 380394005323 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 380394005324 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 380394005325 Soluble P-type ATPase [General function prediction only]; Region: COG4087 380394005326 potassium-transporting ATPase subunit C; Reviewed; Region: PRK00315 380394005327 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 380394005328 substrate binding site [chemical binding]; other site 380394005329 nucleotide binding site [chemical binding]; other site 380394005330 Outer membrane protein family (DUF1597); Region: DUF1597; pfam07642 380394005331 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 380394005332 Nitrogen regulatory protein P-II; Region: P-II; smart00938 380394005333 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 380394005334 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 380394005335 Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966 380394005336 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 380394005337 Trp docking motif [polypeptide binding]; other site 380394005338 active site 380394005339 PQQ-like domain; Region: PQQ_2; pfam13360 380394005340 TPR repeat; Region: TPR_11; pfam13414 380394005341 Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373 380394005342 MG2 domain; Region: A2M_N; pfam01835 380394005343 Proteins similar to alpha2-macroglobulin (alpha (2)-M). Alpha (2)-M is a major carrier protein in serum. It is a broadly specific proteinase inhibitor. The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of...; Region: A2M_like; cd02891 380394005344 surface patch; other site 380394005345 Transglycosylase; Region: Transgly; pfam00912 380394005346 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 380394005347 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 380394005348 Penicillin-Binding Protein C-terminus Family; Region: BiPBP_C; pfam06832 380394005349 Roadblock/LC7 domain; Region: Robl_LC7; cl00886 380394005350 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 380394005351 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 380394005352 Putative transmembrane protein (Alph_Pro_TM); Region: Alph_Pro_TM; cl09826 380394005353 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 380394005354 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 380394005355 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 380394005356 purine monophosphate binding site [chemical binding]; other site 380394005357 dimer interface [polypeptide binding]; other site 380394005358 putative catalytic residues [active] 380394005359 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 380394005360 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 380394005361 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 380394005362 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 380394005363 ATP-grasp domain; Region: ATP-grasp_4; cl17255 380394005364 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 380394005365 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 380394005366 coproporphyrinogen III oxidase; Provisional; Region: PRK05330 380394005367 Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; pfam01218 380394005368 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 380394005369 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 380394005370 quinone interaction residues [chemical binding]; other site 380394005371 active site 380394005372 catalytic residues [active] 380394005373 FMN binding site [chemical binding]; other site 380394005374 substrate binding site [chemical binding]; other site 380394005375 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 380394005376 Coenzyme A binding pocket [chemical binding]; other site 380394005377 Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409 380394005378 Phosphoesterase family; Region: Phosphoesterase; pfam04185 380394005379 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 380394005380 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 380394005381 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 380394005382 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 380394005383 phosphate regulon transcriptional regulatory protein PhoB; Region: PhoB; TIGR02154 380394005384 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 380394005385 DNA binding site [nucleotide binding] 380394005386 Protein of unknown function (DUF3568); Region: DUF3568; pfam12092 380394005387 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 380394005388 Uncharacterized conserved protein [Function unknown]; Region: COG3391 380394005389 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 380394005390 Phosphoesterase family; Region: Phosphoesterase; pfam04185 380394005391 TolA protein; Region: tolA_full; TIGR02794 380394005392 TonB family C-terminal domain; Region: tonB_Cterm; TIGR01352 380394005393 phosphonate degradation operons associated HDIG domain protein; Region: Phn-HD; TIGR03276 380394005394 benzoate transport; Region: 2A0115; TIGR00895 380394005395 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 380394005396 putative substrate translocation pore; other site 380394005397 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 380394005398 phosphonate C-P lyase system protein PhnG; Region: PhnG_redo; TIGR03293 380394005399 phosphonate C-P lyase system protein PhnH; Region: PhnH_redo; TIGR03292 380394005400 Bacterial phosphonate metabolism protein (PhnI); Region: PhnI; pfam05861 380394005401 Phosphonate metabolism protein PhnJ; Region: PhnJ; pfam06007 380394005402 phosphonate C-P lyase system protein PhnK; Provisional; Region: phnK; PRK11701 380394005403 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 380394005404 Walker A/P-loop; other site 380394005405 ATP binding site [chemical binding]; other site 380394005406 Q-loop/lid; other site 380394005407 ABC transporter signature motif; other site 380394005408 Walker B; other site 380394005409 D-loop; other site 380394005410 H-loop/switch region; other site 380394005411 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 380394005412 ABC-type phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PhnL; COG4778 380394005413 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 380394005414 Walker A/P-loop; other site 380394005415 ATP binding site [chemical binding]; other site 380394005416 Q-loop/lid; other site 380394005417 ABC transporter signature motif; other site 380394005418 Walker B; other site 380394005419 D-loop; other site 380394005420 H-loop/switch region; other site 380394005421 phosphonate metabolism protein PhnM; Provisional; Region: PRK15446 380394005422 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 380394005423 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 380394005424 active site 380394005425 putative phosphonate metabolism protein; Region: Phn_opern_protn; TIGR03223 380394005426 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 380394005427 active site 380394005428 phosphonates metabolism transcriptional regulator PhnF; Region: C_P_lyase_phnF; TIGR02325 380394005429 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 380394005430 DNA-binding site [nucleotide binding]; DNA binding site 380394005431 UTRA domain; Region: UTRA; cl17743 380394005432 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 380394005433 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 380394005434 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 380394005435 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 380394005436 N-terminal plug; other site 380394005437 ligand-binding site [chemical binding]; other site 380394005438 Phosphoesterase family; Region: Phosphoesterase; pfam04185 380394005439 acid phosphatase, Burkholderia-type; Region: acid_phos_Burk; TIGR03397 380394005440 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 380394005441 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 380394005442 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 380394005443 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 380394005444 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 380394005445 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 380394005446 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 380394005447 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 380394005448 N-terminal plug; other site 380394005449 ligand-binding site [chemical binding]; other site 380394005450 Uncharacterized conserved protein [Function unknown]; Region: COG3391 380394005451 Phosphoesterase family; Region: Phosphoesterase; pfam04185 380394005452 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 380394005453 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 380394005454 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 380394005455 active site 380394005456 intermolecular recognition site; other site 380394005457 dimerization interface [polypeptide binding]; other site 380394005458 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 380394005459 DNA binding site [nucleotide binding] 380394005460 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 380394005461 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 380394005462 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 380394005463 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 380394005464 catalytic core [active] 380394005465 Outer membrane lipoprotein Slp family; Region: Slp; pfam03843 380394005466 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 380394005467 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 380394005468 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 380394005469 dimer interface [polypeptide binding]; other site 380394005470 phosphorylation site [posttranslational modification] 380394005471 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 380394005472 ATP binding site [chemical binding]; other site 380394005473 Mg2+ binding site [ion binding]; other site 380394005474 G-X-G motif; other site 380394005475 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 380394005476 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 380394005477 active site 380394005478 phosphorylation site [posttranslational modification] 380394005479 intermolecular recognition site; other site 380394005480 dimerization interface [polypeptide binding]; other site 380394005481 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 380394005482 DNA binding site [nucleotide binding] 380394005483 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 380394005484 catalytic site [active] 380394005485 putative active site [active] 380394005486 putative substrate binding site [chemical binding]; other site 380394005487 dimer interface [polypeptide binding]; other site 380394005488 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 380394005489 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 380394005490 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 380394005491 UDP-glucose 4 epimerase (G4E), subgroup 3, extended (e) SDRs; Region: UDP_G4E_3_SDR_e; cd05240 380394005492 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 380394005493 putative NAD(P) binding site [chemical binding]; other site 380394005494 active site 380394005495 putative substrate binding site [chemical binding]; other site 380394005496 P-aminobenzoate N-oxygenase AurF; Region: AurF; pfam11583 380394005497 phosphoglucomutase; Region: PLN02307 380394005498 Phosphoglucomutase 1 (PGM1) catalyzes the bidirectional interconversion of glucose-1-phosphate (G-1-P) and glucose-6-phosphate (G-6-P) via a glucose 1,6-diphosphate intermediate, an important metabolic step in prokaryotes and eukaryotes. In one direction; Region: PGM1; cd03085 380394005499 substrate binding site [chemical binding]; other site 380394005500 dimer interface [polypeptide binding]; other site 380394005501 active site 380394005502 metal binding site [ion binding]; metal-binding site 380394005503 YtxH-like protein; Region: YtxH; cl02079 380394005504 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 380394005505 magnesium-transporting ATPase; Provisional; Region: PRK15122 380394005506 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 380394005507 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 380394005508 Soluble P-type ATPase [General function prediction only]; Region: COG4087 380394005509 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 380394005510 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 380394005511 Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4705 380394005512 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 380394005513 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 380394005514 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 380394005515 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 380394005516 putative substrate translocation pore; other site 380394005517 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 380394005518 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 380394005519 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 380394005520 dimerization interface [polypeptide binding]; other site 380394005521 substrate binding pocket [chemical binding]; other site 380394005522 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 380394005523 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 380394005524 Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546 380394005525 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 380394005526 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 380394005527 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 380394005528 DNA binding residues [nucleotide binding] 380394005529 DNA primase; Validated; Region: dnaG; PRK05667 380394005530 CHC2 zinc finger; Region: zf-CHC2; pfam01807 380394005531 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 380394005532 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 380394005533 active site 380394005534 metal binding site [ion binding]; metal-binding site 380394005535 interdomain interaction site; other site 380394005536 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 380394005537 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 380394005538 MutS domain III; Region: MutS_III; pfam05192 380394005539 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 380394005540 Walker A/P-loop; other site 380394005541 ATP binding site [chemical binding]; other site 380394005542 Q-loop/lid; other site 380394005543 ABC transporter signature motif; other site 380394005544 Walker B; other site 380394005545 D-loop; other site 380394005546 H-loop/switch region; other site 380394005547 Smr domain; Region: Smr; pfam01713 380394005548 Yqey-like protein; Region: YqeY; pfam09424 380394005549 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 380394005550 RNA polymerase sigma factor RpoD, C-terminal domain; Region: RpoD_Cterm; TIGR02393 380394005551 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 380394005552 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 380394005553 DNA binding residues [nucleotide binding] 380394005554 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 380394005555 active site 380394005556 dimerization interface [polypeptide binding]; other site 380394005557 ribonuclease PH; Reviewed; Region: rph; PRK00173 380394005558 Ribonuclease PH; Region: RNase_PH_bact; cd11362 380394005559 hexamer interface [polypeptide binding]; other site 380394005560 active site 380394005561 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 380394005562 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 380394005563 ligand binding site [chemical binding]; other site 380394005564 flexible hinge region; other site 380394005565 ATP-dependent protease La (LON) domain; Region: LON; pfam02190 380394005566 coproporphyrinogen III oxidase; Provisional; Region: PRK08898 380394005567 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 380394005568 FeS/SAM binding site; other site 380394005569 HemN C-terminal domain; Region: HemN_C; pfam06969 380394005570 Uncharacterized conserved protein [Function unknown]; Region: COG3461 380394005571 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 380394005572 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 380394005573 RNA binding surface [nucleotide binding]; other site 380394005574 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 380394005575 active site 380394005576 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 380394005577 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 380394005578 putative substrate translocation pore; other site 380394005579 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 380394005580 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 380394005581 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 380394005582 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 380394005583 Methyltransferase domain; Region: Methyltransf_23; pfam13489 380394005584 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 380394005585 S-adenosylmethionine binding site [chemical binding]; other site 380394005586 phosphoribosylformylglycinamidine synthase; Provisional; Region: PRK05297 380394005587 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 380394005588 dimerization interface [polypeptide binding]; other site 380394005589 ATP binding site [chemical binding]; other site 380394005590 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 380394005591 dimerization interface [polypeptide binding]; other site 380394005592 ATP binding site [chemical binding]; other site 380394005593 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 380394005594 putative active site [active] 380394005595 catalytic triad [active] 380394005596 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 380394005597 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 380394005598 ATP binding site [chemical binding]; other site 380394005599 active site 380394005600 substrate binding site [chemical binding]; other site 380394005601 adenylosuccinate lyase; Provisional; Region: PRK07492 380394005602 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 380394005603 tetramer interface [polypeptide binding]; other site 380394005604 active site 380394005605 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 380394005606 dihydrodipicolinate synthase; Region: dapA; TIGR00674 380394005607 dimer interface [polypeptide binding]; other site 380394005608 active site 380394005609 catalytic residue [active] 380394005610 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 380394005611 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 380394005612 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 380394005613 active site 380394005614 metal binding site [ion binding]; metal-binding site 380394005615 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 380394005616 thioredoxin 2; Provisional; Region: PRK10996 380394005617 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 380394005618 catalytic residues [active] 380394005619 Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418 380394005620 GSH binding site [chemical binding]; other site 380394005621 catalytic residues [active] 380394005622 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 380394005623 active site residue [active] 380394005624 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 380394005625 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 380394005626 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 380394005627 Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999 380394005628 HlyD family secretion protein; Region: HlyD_3; pfam13437 380394005629 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 380394005630 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 380394005631 dimerization interface [polypeptide binding]; other site 380394005632 putative DNA binding site [nucleotide binding]; other site 380394005633 putative Zn2+ binding site [ion binding]; other site 380394005634 HsdM N-terminal domain; Region: HsdM_N; pfam12161 380394005635 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 380394005636 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 380394005637 S-adenosylmethionine binding site [chemical binding]; other site 380394005638 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 380394005639 Walker B; other site 380394005640 D-loop; other site 380394005641 H-loop/switch region; other site 380394005642 Superfamily II helicase [General function prediction only]; Region: COG1204 380394005643 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 380394005644 ATP binding site [chemical binding]; other site 380394005645 putative Mg++ binding site [ion binding]; other site 380394005646 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 380394005647 nucleotide binding region [chemical binding]; other site 380394005648 ATP-binding site [chemical binding]; other site 380394005649 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 380394005650 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 380394005651 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 380394005652 Divergent AAA domain; Region: AAA_4; pfam04326 380394005653 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 380394005654 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 380394005655 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 380394005656 ATP binding site [chemical binding]; other site 380394005657 putative Mg++ binding site [ion binding]; other site 380394005658 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; cl00311 380394005659 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 380394005660 SCP-2 sterol transfer family; Region: SCP2; pfam02036 380394005661 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179 380394005662 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 380394005663 putative ATP binding site [chemical binding]; other site 380394005664 putative substrate interface [chemical binding]; other site 380394005665 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 380394005666 active site 380394005667 Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988 380394005668 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 380394005669 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 380394005670 Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988 380394005671 Membrane fusogenic activity; Region: BMFP; pfam04380 380394005672 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 380394005673 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 380394005674 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 380394005675 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 380394005676 Transposase; Region: HTH_Tnp_1; cl17663 380394005677 Homeodomain-like domain; Region: HTH_32; pfam13565 380394005678 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 380394005679 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 380394005680 transposase; Validated; Region: PRK08181 380394005681 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 380394005682 Walker A motif; other site 380394005683 ATP binding site [chemical binding]; other site 380394005684 Integrase core domain; Region: rve; pfam00665 380394005685 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 380394005686 integron integrase; Region: integrase_gron; TIGR02249 380394005687 active site 380394005688 DNA binding site [nucleotide binding] 380394005689 Int/Topo IB signature motif; other site 380394005690 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 380394005691 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N2; pfam13495 380394005692 INT_SG5, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 5, N- and C-terminal domains. The CD contains mainly predicted bacterial integrase/recombinases; Region: INT_SG5; cd01190 380394005693 Int/Topo IB signature motif; other site 380394005694 Integrase core domain; Region: rve; pfam00665 380394005695 Helix-turn-helix domain; Region: HTH_38; pfam13936 380394005696 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4951 380394005697 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 380394005698 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 380394005699 ATP binding site [chemical binding]; other site 380394005700 putative Mg++ binding site [ion binding]; other site 380394005701 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 380394005702 nucleotide binding region [chemical binding]; other site 380394005703 ATP-binding site [chemical binding]; other site 380394005704 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 380394005705 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 380394005706 Coenzyme A binding pocket [chemical binding]; other site 380394005707 NADH dehydrogenase subunit B; Validated; Region: PRK06411 380394005708 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 380394005709 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 380394005710 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 380394005711 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 380394005712 Walker A motif; other site 380394005713 ATP binding site [chemical binding]; other site 380394005714 Walker B motif; other site 380394005715 Protein of unknown function (DUF497); Region: DUF497; cl01108 380394005716 Domain of unknown function (DUF4415); Region: DUF4415; pfam14384 380394005717 Divergent AAA domain; Region: AAA_4; pfam04326 380394005718 Plasmid recombination enzyme; Region: Mob_Pre; pfam01076 380394005719 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 380394005720 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 380394005721 Cd(II)/Pb(II)-responsive transcriptional regulator; Region: CadR-PbrR; TIGR02047 380394005722 Helix-Turn-Helix DNA binding domain of the CadR and PbrR transcription regulators; Region: HTH_CadR-PbrR; cd04784 380394005723 DNA binding residues [nucleotide binding] 380394005724 dimer interface [polypeptide binding]; other site 380394005725 putative metal binding site [ion binding]; other site 380394005726 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 380394005727 S-adenosylmethionine binding site [chemical binding]; other site 380394005728 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 380394005729 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 380394005730 gamma subunit interface [polypeptide binding]; other site 380394005731 epsilon subunit interface [polypeptide binding]; other site 380394005732 LBP interface [polypeptide binding]; other site 380394005733 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 380394005734 Copper binding periplasmic protein CusF; Region: CusF_Ec; pfam11604 380394005735 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 380394005736 Mitochondrial biogenesis AIM24; Region: AIM24; cl00884 380394005737 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 380394005738 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 380394005739 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 380394005740 HlyD family secretion protein; Region: HlyD_3; pfam13437 380394005741 Outer membrane efflux protein; Region: OEP; pfam02321 380394005742 Outer membrane efflux protein; Region: OEP; pfam02321 380394005743 Predicted membrane protein [Function unknown]; Region: COG3462 380394005744 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 380394005745 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 380394005746 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 380394005747 motif II; other site 380394005748 Domain of unknown function DUF302; Region: DUF302; pfam03625 380394005749 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 380394005750 metal-binding site [ion binding] 380394005751 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 380394005752 catalytic residues [active] 380394005753 Cytochrome c; Region: Cytochrom_C; cl11414 380394005754 ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; pfam12762 380394005755 Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831 380394005756 Domain of unknown function (DUF4338); Region: DUF4338; pfam14236 380394005757 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 380394005758 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880 380394005759 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 380394005760 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 380394005761 Nitrogen regulatory protein P-II; Region: P-II; smart00938 380394005762 Outer membrane protein family (DUF1597); Region: DUF1597; pfam07642 380394005763 gamma-glutamyl kinase; Provisional; Region: PRK05429 380394005764 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 380394005765 nucleotide binding site [chemical binding]; other site 380394005766 homotetrameric interface [polypeptide binding]; other site 380394005767 putative phosphate binding site [ion binding]; other site 380394005768 putative allosteric binding site; other site 380394005769 RimK-like ATPgrasp N-terminal domain; Region: RLAN; pfam14401 380394005770 Glutathione synthase/Ribosomal protein S6 modification enzyme (glutaminyl transferase) [Coenzyme metabolism / Translation, ribosomal structure and biogenesis]; Region: RimK; COG0189 380394005771 ATP-grasp domain; Region: ATP-grasp_4; cl17255 380394005772 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 380394005773 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 380394005774 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 380394005775 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 380394005776 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 380394005777 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 380394005778 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 380394005779 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 380394005780 IHF - DNA interface [nucleotide binding]; other site 380394005781 IHF dimer interface [polypeptide binding]; other site 380394005782 potassium-transporting ATPase subunit C; Reviewed; Region: PRK00315 380394005783 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 380394005784 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 380394005785 Soluble P-type ATPase [General function prediction only]; Region: COG4087 380394005786 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 380394005787 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 380394005788 putative mercury transport protein MerC; Provisional; Region: PRK13755 380394005789 putative mercuric reductase; Provisional; Region: PRK13748 380394005790 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 380394005791 metal-binding site [ion binding] 380394005792 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 380394005793 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 380394005794 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 380394005795 Glycoside hydrolase family 15, N-terminal domain; Region: GH15_N; cd07430 380394005796 Domain interface; other site 380394005797 glucan 1,4-alpha-glucosidase; Region: glucan_glucosid; TIGR01535 380394005798 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 380394005799 transcriptional regulator MerD; Provisional; Region: PRK13749 380394005800 Helix-Turn-Helix DNA binding domain of the MerD transcription regulator; Region: HTH_MerD; cd01111 380394005801 DNA binding residues [nucleotide binding] 380394005802 putative dimer interface [polypeptide binding]; other site 380394005803 Protein of unknown function (DUF2459); Region: DUF2459; cl09819 380394005804 Protein of unknown function (DUF3579); Region: DUF3579; pfam12112 380394005805 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 380394005806 TniQ; Region: TniQ; pfam06527 380394005807 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880 380394005808 Domain of unknown function (DUF4338); Region: DUF4338; pfam14236 380394005809 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 380394005810 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 380394005811 AAA domain; Region: AAA_22; pfam13401 380394005812 Walker A motif; other site 380394005813 ATP binding site [chemical binding]; other site 380394005814 Walker B motif; other site 380394005815 Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299 380394005816 Domain of unknown function (DUF4338); Region: DUF4338; pfam14236 380394005817 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 380394005818 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880 380394005819 Helix-turn-helix domain; Region: HTH_28; pfam13518 380394005820 Winged helix-turn helix; Region: HTH_29; pfam13551 380394005821 Integrase core domain; Region: rve; pfam00665 380394005822 TnsA endonuclease N terminal; Region: Tn7_Tnp_TnsA_N; pfam08722 380394005823 TnsA endonuclease C terminal; Region: Tn7_Tnp_TnsA_C; pfam08721 380394005824 DsrE/DsrF/DrsH-like family; Region: DrsE_2; cl17453 380394005825 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 380394005826 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 380394005827 DNA binding residues [nucleotide binding] 380394005828 dimer interface [polypeptide binding]; other site 380394005829 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 380394005830 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 380394005831 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 380394005832 G1 box; other site 380394005833 putative GEF interaction site [polypeptide binding]; other site 380394005834 GTP/Mg2+ binding site [chemical binding]; other site 380394005835 Switch I region; other site 380394005836 G2 box; other site 380394005837 G3 box; other site 380394005838 Switch II region; other site 380394005839 G4 box; other site 380394005840 G5 box; other site 380394005841 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 380394005842 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 380394005843 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 380394005844 Coenzyme A binding pocket [chemical binding]; other site 380394005845 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 380394005846 Glycoprotease family; Region: Peptidase_M22; pfam00814 380394005847 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 380394005848 DEAD/DEAH box helicase; Region: DEAD; pfam00270 380394005849 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 380394005850 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 380394005851 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 380394005852 NlpC/P60 family; Region: NLPC_P60; pfam00877 380394005853 Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966 380394005854 FeoA domain; Region: FeoA; cl00838 380394005855 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 380394005856 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 380394005857 G1 box; other site 380394005858 GTP/Mg2+ binding site [chemical binding]; other site 380394005859 Switch I region; other site 380394005860 G2 box; other site 380394005861 G3 box; other site 380394005862 Switch II region; other site 380394005863 G4 box; other site 380394005864 G5 box; other site 380394005865 Nucleoside recognition; Region: Gate; pfam07670 380394005866 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 380394005867 FeoC like transcriptional regulator; Region: FeoC; cl17677 380394005868 N-carbamoylputrescine amidohydrolase (CPA) (class 11 nitrilases); Region: CPA; cd07573 380394005869 N-carbamoylputrescine amidase; Region: agmatine_aguB; TIGR03381 380394005870 putative active site; other site 380394005871 catalytic triad [active] 380394005872 putative dimer interface [polypeptide binding]; other site 380394005873 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 380394005874 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 380394005875 catalytic triad [active] 380394005876 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 380394005877 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 380394005878 ornithine carbamoyltransferase; Provisional; Region: PRK00779 380394005879 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 380394005880 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 380394005881 conserved cys residue [active] 380394005882 putative DNA-binding transcriptional regulator; Provisional; Region: PRK10837 380394005883 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 380394005884 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 380394005885 putative dimerization interface [polypeptide binding]; other site 380394005886 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK08375 380394005887 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 380394005888 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 380394005889 active site 380394005890 catalytic tetrad [active] 380394005891 Class I histone deacetylase AcuC (Acetoin utilization protein)-like enzymes; Region: HDAC_AcuC_like; cd09994 380394005892 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 380394005893 active site 380394005894 Zn binding site [ion binding]; other site 380394005895 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 380394005896 metal ion-dependent adhesion site (MIDAS); other site 380394005897 MoxR-like ATPases [General function prediction only]; Region: COG0714 380394005898 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 380394005899 Walker A motif; other site 380394005900 ATP binding site [chemical binding]; other site 380394005901 Walker B motif; other site 380394005902 CbbQ/NirQ/NorQ C-terminal; Region: CbbQ_C; pfam08406 380394005903 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 380394005904 Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; cl17479 380394005905 Biotin synthase-related enzyme [General function prediction only]; Region: COG2516 380394005906 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 380394005907 FeS/SAM binding site; other site 380394005908 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 380394005909 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 380394005910 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 380394005911 Uncharacterized homolog of biotin synthetase [Function unknown]; Region: COG1856 380394005912 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 380394005913 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 380394005914 lipoyl attachment site [posttranslational modification]; other site 380394005915 Predicted peroxiredoxins [General function prediction only]; Region: COG2044 380394005916 glycine cleavage system protein H; Provisional; Region: PRK13380 380394005917 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 380394005918 lipoyl attachment site [posttranslational modification]; other site 380394005919 Heterodisulfide reductase, subunit B [Energy production and conversion]; Region: HdrB; COG2048 380394005920 Cysteine-rich domain; Region: CCG; pfam02754 380394005921 Cysteine-rich domain; Region: CCG; pfam02754 380394005922 Domain of unknown function (DUF4338); Region: DUF4338; pfam14236 380394005923 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 380394005924 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880 380394005925 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 380394005926 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 380394005927 Heterodisulfide reductase, subunit B [Energy production and conversion]; Region: HdrB; COG2048 380394005928 Cysteine-rich domain; Region: CCG; pfam02754 380394005929 4Fe-4S dicluster domain; Region: Fer4_17; pfam13534 380394005930 DsrE/DsrF/DrsH-like family; Region: DrsE_2; pfam13686 380394005931 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 380394005932 CPxP motif; other site 380394005933 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 380394005934 active site residue [active] 380394005935 molybdenum cofactor biosynthesis protein A, bacterial; Region: moaA; TIGR02666 380394005936 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 380394005937 FeS/SAM binding site; other site 380394005938 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 380394005939 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 380394005940 trimer interface [polypeptide binding]; other site 380394005941 dimer interface [polypeptide binding]; other site 380394005942 putative active site [active] 380394005943 rod shape-determining protein MreB; Provisional; Region: PRK13927 380394005944 MreB and similar proteins; Region: MreB_like; cd10225 380394005945 nucleotide binding site [chemical binding]; other site 380394005946 Mg binding site [ion binding]; other site 380394005947 putative protofilament interaction site [polypeptide binding]; other site 380394005948 RodZ interaction site [polypeptide binding]; other site 380394005949 rod shape-determining protein MreC; Provisional; Region: PRK13922 380394005950 rod shape-determining protein MreC; Region: MreC; pfam04085 380394005951 rod shape-determining protein MreD; Region: shape_MreD; TIGR03426 380394005952 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 380394005953 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 380394005954 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 380394005955 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 380394005956 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 380394005957 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 380394005958 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 380394005959 Protein of unknown function (DUF493); Region: DUF493; pfam04359 380394005960 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 380394005961 lipoyl synthase; Provisional; Region: PRK05481 380394005962 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 380394005963 FeS/SAM binding site; other site 380394005964 Uncharacterized conserved protein [Function unknown]; Region: COG1434 380394005965 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 380394005966 putative active site [active] 380394005967 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 380394005968 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 380394005969 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 380394005970 active site 380394005971 phosphorylation site [posttranslational modification] 380394005972 intermolecular recognition site; other site 380394005973 dimerization interface [polypeptide binding]; other site 380394005974 Conserved hypothetical ATP binding protein; Region: ATP_bind_1; pfam03029 380394005975 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 380394005976 G1 box; other site 380394005977 GTP/Mg2+ binding site [chemical binding]; other site 380394005978 G2 box; other site 380394005979 Switch I region; other site 380394005980 G3 box; other site 380394005981 Switch II region; other site 380394005982 G4 box; other site 380394005983 G5 box; other site 380394005984 Roadblock/LC7 domain; Region: Robl_LC7; cl00886 380394005985 Uncharacterized distant relative of homeotic protein bithoraxoid [General function prediction only]; Region: COG2018 380394005986 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 380394005987 dimer interface [polypeptide binding]; other site 380394005988 motif 1; other site 380394005989 active site 380394005990 motif 2; other site 380394005991 motif 3; other site 380394005992 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 380394005993 D,D-heptose 1,7-bisphosphate phosphatase; Validated; Region: PRK08942 380394005994 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 380394005995 active site 380394005996 motif I; other site 380394005997 motif II; other site 380394005998 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 380394005999 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 380394006000 putative acyl-acceptor binding pocket; other site 380394006001 ribosomal protein S6 modification protein; Provisional; Region: PRK10446 380394006002 ATP-grasp domain; Region: ATP-grasp_4; cl17255 380394006003 Heterodisulfide reductase, subunit B [Energy production and conversion]; Region: HdrB; COG2048 380394006004 Cysteine-rich domain; Region: CCG; pfam02754 380394006005 Uncharacterized BCR, COG1636; Region: DUF208; pfam02677 380394006006 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 380394006007 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 380394006008 amidase catalytic site [active] 380394006009 Zn binding residues [ion binding]; other site 380394006010 substrate binding site [chemical binding]; other site 380394006011 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 380394006012 catalytic residues [active] 380394006013 glutathionine S-transferase; Provisional; Region: PRK10542 380394006014 GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057 380394006015 C-terminal domain interface [polypeptide binding]; other site 380394006016 GSH binding site (G-site) [chemical binding]; other site 380394006017 dimer interface [polypeptide binding]; other site 380394006018 C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188 380394006019 dimer interface [polypeptide binding]; other site 380394006020 N-terminal domain interface [polypeptide binding]; other site 380394006021 substrate binding pocket (H-site) [chemical binding]; other site 380394006022 Predicted transcriptional regulators [Transcription]; Region: COG1733 380394006023 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 380394006024 2-isopropylmalate synthase; Validated; Region: PRK00915 380394006025 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 380394006026 active site 380394006027 catalytic residues [active] 380394006028 metal binding site [ion binding]; metal-binding site 380394006029 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 380394006030 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 380394006031 PAS domain; Region: PAS_9; pfam13426 380394006032 putative active site [active] 380394006033 heme pocket [chemical binding]; other site 380394006034 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 380394006035 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 380394006036 Walker A motif; other site 380394006037 ATP binding site [chemical binding]; other site 380394006038 Walker B motif; other site 380394006039 arginine finger; other site 380394006040 Homeodomain-like domain; Region: HTH_23; pfam13384 380394006041 DsrE/DsrF/DrsH-like family; Region: DrsE_2; cl17453 380394006042 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 380394006043 CPxP motif; other site 380394006044 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 380394006045 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 380394006046 Methyltransferase domain; Region: Methyltransf_25; pfam13649 380394006047 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 380394006048 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 380394006049 Walker A/P-loop; other site 380394006050 ATP binding site [chemical binding]; other site 380394006051 Q-loop/lid; other site 380394006052 ABC transporter signature motif; other site 380394006053 Walker B; other site 380394006054 D-loop; other site 380394006055 H-loop/switch region; other site 380394006056 Helix-Turn-Helix DNA binding domain of putative MlrA-like transcription regulators; Region: HTH_MlrA-like_sg2; cd04765 380394006057 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 380394006058 DNA binding residues [nucleotide binding] 380394006059 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 380394006060 IHF - DNA interface [nucleotide binding]; other site 380394006061 IHF dimer interface [polypeptide binding]; other site 380394006062 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 380394006063 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 380394006064 putative tRNA-binding site [nucleotide binding]; other site 380394006065 B3/4 domain; Region: B3_4; pfam03483 380394006066 tRNA synthetase B5 domain; Region: B5; smart00874 380394006067 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 380394006068 dimer interface [polypeptide binding]; other site 380394006069 motif 1; other site 380394006070 motif 3; other site 380394006071 motif 2; other site 380394006072 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 380394006073 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 380394006074 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 380394006075 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 380394006076 dimer interface [polypeptide binding]; other site 380394006077 motif 1; other site 380394006078 active site 380394006079 motif 2; other site 380394006080 motif 3; other site 380394006081 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 380394006082 23S rRNA binding site [nucleotide binding]; other site 380394006083 L21 binding site [polypeptide binding]; other site 380394006084 L13 binding site [polypeptide binding]; other site 380394006085 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 380394006086 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 380394006087 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 380394006088 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 380394006089 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 380394006090 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 380394006091 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 380394006092 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 380394006093 active site 380394006094 dimer interface [polypeptide binding]; other site 380394006095 motif 1; other site 380394006096 motif 2; other site 380394006097 motif 3; other site 380394006098 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 380394006099 anticodon binding site; other site 380394006100 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 380394006101 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 380394006102 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 380394006103 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 380394006104 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 380394006105 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 380394006106 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 380394006107 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 380394006108 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 380394006109 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 380394006110 NADH-quinone oxidoreductase, chain I; Region: NuoI; TIGR01971 380394006111 4Fe-4S binding domain; Region: Fer4; pfam00037 380394006112 4Fe-4S binding domain; Region: Fer4; pfam00037 380394006113 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 380394006114 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 380394006115 NADH dehydrogenase subunit G; Validated; Region: PRK09129 380394006116 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 380394006117 catalytic loop [active] 380394006118 iron binding site [ion binding]; other site 380394006119 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 380394006120 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 380394006121 molybdopterin cofactor binding site; other site 380394006122 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 380394006123 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 380394006124 SLBB domain; Region: SLBB; pfam10531 380394006125 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928 380394006126 NADH dehydrogenase subunit E; Validated; Region: PRK07539 380394006127 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 380394006128 putative dimer interface [polypeptide binding]; other site 380394006129 [2Fe-2S] cluster binding site [ion binding]; other site 380394006130 NADH dehydrogenase subunit D; Validated; Region: PRK06075 380394006131 NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649 380394006132 NADH dehydrogenase subunit C; Provisional; Region: PRK06074 380394006133 NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961 380394006134 NADH dehydrogenase subunit B; Validated; Region: PRK06411 380394006135 NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602 380394006136 protein translocase, SecG subunit; Region: secG; TIGR00810 380394006137 triosephosphate isomerase; Provisional; Region: PRK14567 380394006138 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 380394006139 dimer interface [polypeptide binding]; other site 380394006140 substrate binding site [chemical binding]; other site 380394006141 catalytic triad [active] 380394006142 phosphoglucosamine mutase; Provisional; Region: glmM; PRK10887 380394006143 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 380394006144 active site 380394006145 substrate binding site [chemical binding]; other site 380394006146 metal binding site [ion binding]; metal-binding site 380394006147 dihydropteroate synthase; Region: DHPS; TIGR01496 380394006148 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 380394006149 substrate binding pocket [chemical binding]; other site 380394006150 dimer interface [polypeptide binding]; other site 380394006151 inhibitor binding site; inhibition site 380394006152 FtsH Extracellular; Region: FtsH_ext; pfam06480 380394006153 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 380394006154 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 380394006155 Walker A motif; other site 380394006156 ATP binding site [chemical binding]; other site 380394006157 Walker B motif; other site 380394006158 arginine finger; other site 380394006159 Peptidase family M41; Region: Peptidase_M41; pfam01434 380394006160 protease TldD; Provisional; Region: tldD; PRK10735 380394006161 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07207 380394006162 ATP cone domain; Region: ATP-cone; pfam03477 380394006163 ATP cone domain; Region: ATP-cone; pfam03477 380394006164 Class I ribonucleotide reductase; Region: RNR_I; cd01679 380394006165 active site 380394006166 dimer interface [polypeptide binding]; other site 380394006167 catalytic residues [active] 380394006168 effector binding site; other site 380394006169 R2 peptide binding site; other site 380394006170 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 380394006171 dimer interface [polypeptide binding]; other site 380394006172 putative radical transfer pathway; other site 380394006173 diiron center [ion binding]; other site 380394006174 tyrosyl radical; other site 380394006175 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 380394006176 dimerization interface [polypeptide binding]; other site 380394006177 putative DNA binding site [nucleotide binding]; other site 380394006178 putative Zn2+ binding site [ion binding]; other site 380394006179 Major Facilitator Superfamily; Region: MFS_1; pfam07690 380394006180 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 380394006181 putative substrate translocation pore; other site 380394006182 DsrE/DsrF-like family; Region: DrsE; cl00672 380394006183 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 380394006184 CopC domain; Region: CopC; pfam04234 380394006185 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 380394006186 active site 380394006187 DNA polymerase IV; Validated; Region: PRK02406 380394006188 DNA binding site [nucleotide binding] 380394006189 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 380394006190 oligomeric interface; other site 380394006191 homodimer interface [polypeptide binding]; other site 380394006192 putative active site [active] 380394006193 Protein of unknown function DUF72; Region: DUF72; pfam01904 380394006194 Domain of unknown function (DUF4415); Region: DUF4415; pfam14384 380394006195 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 380394006196 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 380394006197 trimer interface [polypeptide binding]; other site 380394006198 active site 380394006199 antiporter inner membrane protein; Provisional; Region: PRK11670 380394006200 Domain of unknown function DUF59; Region: DUF59; pfam01883 380394006201 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 380394006202 Walker A motif; other site 380394006203 Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992 380394006204 dihydrodipicolinate reductase; Provisional; Region: PRK00048 380394006205 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 380394006206 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 380394006207 chaperone protein DnaJ; Provisional; Region: PRK10767 380394006208 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 380394006209 HSP70 interaction site [polypeptide binding]; other site 380394006210 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 380394006211 Zn binding sites [ion binding]; other site 380394006212 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 380394006213 dimer interface [polypeptide binding]; other site 380394006214 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 380394006215 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 380394006216 nucleotide binding site [chemical binding]; other site 380394006217 GrpE; Region: GrpE; pfam01025 380394006218 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 380394006219 dimer interface [polypeptide binding]; other site 380394006220 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 380394006221 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 380394006222 Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444 380394006223 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 380394006224 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 380394006225 methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133 380394006226 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 380394006227 active site 380394006228 HIGH motif; other site 380394006229 KMSKS motif; other site 380394006230 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 380394006231 tRNA binding surface [nucleotide binding]; other site 380394006232 anticodon binding site; other site 380394006233 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 380394006234 dimer interface [polypeptide binding]; other site 380394006235 putative tRNA-binding site [nucleotide binding]; other site 380394006236 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase [Amino acid transport and metabolism]; Region: AroA; COG2876 380394006237 3-deoxy-D-manno-octulosonic acid (KDO) 8-phosphate synthase [Cell envelope biogenesis, outer membrane]; Region: KdsA; cl17225 380394006238 fumarate hydratase; Reviewed; Region: fumC; PRK00485 380394006239 Class II fumarases; Region: Fumarase_classII; cd01362 380394006240 active site 380394006241 tetramer interface [polypeptide binding]; other site 380394006242 oligoendopeptidase, pepF/M3 family; Region: M3_fam_3; TIGR02290 380394006243 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_5; cd09610 380394006244 active site 380394006245 Zn binding site [ion binding]; other site 380394006246 Domain of unknown function (DUF1841); Region: DUF1841; pfam08897 380394006247 3-deoxy-D-manno-octulosonic-acid transferase [Cell envelope biogenesis, outer membrane]; Region: KdtA; COG1519 380394006248 glycogen synthase; Provisional; Region: glgA; PRK00654 380394006249 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 380394006250 ADP-binding pocket [chemical binding]; other site 380394006251 homodimer interface [polypeptide binding]; other site 380394006252 Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236 380394006253 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 380394006254 Beta-Casp domain; Region: Beta-Casp; smart01027 380394006255 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 380394006256 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 380394006257 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 380394006258 minor groove reading motif; other site 380394006259 helix-hairpin-helix signature motif; other site 380394006260 substrate binding pocket [chemical binding]; other site 380394006261 active site 380394006262 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 380394006263 Domain of unknown function DUF29; Region: DUF29; pfam01724 380394006264 TPR repeat; Region: TPR_11; pfam13414 380394006265 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 380394006266 binding surface 380394006267 TPR motif; other site 380394006268 TPR repeat; Region: TPR_11; pfam13414 380394006269 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 380394006270 binding surface 380394006271 TPR motif; other site 380394006272 TPR repeat; Region: TPR_11; pfam13414 380394006273 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 380394006274 binding surface 380394006275 TPR motif; other site 380394006276 Tetratricopeptide repeat; Region: TPR_16; pfam13432 380394006277 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 380394006278 Left-handed beta-roll, including virulence factors and various other proteins; Region: LbR-like; cl17507 380394006279 trimer interface [polypeptide binding]; other site 380394006280 YadA-like C-terminal region; Region: YadA; pfam03895 380394006281 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 380394006282 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 380394006283 ligand binding site [chemical binding]; other site 380394006284 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 380394006285 Sel1-like repeats; Region: SEL1; smart00671 380394006286 Sel1-like repeats; Region: SEL1; smart00671 380394006287 Sel1-like repeats; Region: SEL1; smart00671 380394006288 Sel1-like repeats; Region: SEL1; smart00671 380394006289 Gram-negative bacterial tonB protein; Region: TonB; cl10048 380394006290 Outer membrane efflux protein; Region: OEP; pfam02321 380394006291 Outer membrane efflux protein; Region: OEP; pfam02321 380394006292 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 380394006293 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 380394006294 HlyD family secretion protein; Region: HlyD_3; pfam13437 380394006295 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 380394006296 putative active site [active] 380394006297 type I secretion system ABC transporter, HlyB family; Region: type_I_sec_HlyB; TIGR01846 380394006298 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 380394006299 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 380394006300 Walker A/P-loop; other site 380394006301 ATP binding site [chemical binding]; other site 380394006302 Q-loop/lid; other site 380394006303 ABC transporter signature motif; other site 380394006304 Walker B; other site 380394006305 D-loop; other site 380394006306 H-loop/switch region; other site 380394006307 Protein of unknown function (DUF2968); Region: DUF2968; pfam11180 380394006308 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 380394006309 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 380394006310 Walker A motif; other site 380394006311 ATP binding site [chemical binding]; other site 380394006312 Walker B motif; other site 380394006313 arginine finger; other site 380394006314 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 380394006315 Predicted membrane protein [Function unknown]; Region: COG4655 380394006316 Putative Tad-like Flp pilus-assembly; Region: Tad_C; pfam09977 380394006317 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 380394006318 binding surface 380394006319 TPR motif; other site 380394006320 TPR repeat; Region: TPR_11; pfam13414 380394006321 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 380394006322 binding surface 380394006323 TPR motif; other site 380394006324 Flp pilus assembly protein TadC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: TadC; COG2064 380394006325 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 380394006326 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 380394006327 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 380394006328 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 380394006329 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 380394006330 ATP binding site [chemical binding]; other site 380394006331 Walker A motif; other site 380394006332 hexamer interface [polypeptide binding]; other site 380394006333 Walker B motif; other site 380394006334 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 380394006335 Flp pilus assembly protein, ATPase CpaE [Intracellular trafficking and secretion]; Region: CpaE; COG4963 380394006336 Pilus formation protein N terminal region; Region: T2SS-T3SS_pil_N; pfam13629 380394006337 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 380394006338 Domains similar to fish antifreeze type III protein; Region: SAF; cl00555 380394006339 Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961 380394006340 TadE-like protein; Region: TadE; pfam07811 380394006341 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 380394006342 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880 380394006343 Domain of unknown function (DUF4338); Region: DUF4338; pfam14236 380394006344 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 380394006345 Flp/Fap pilin component; Region: Flp_Fap; cl01585 380394006346 Superinfection immunity protein; Region: Imm_superinfect; pfam14373 380394006347 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 380394006348 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 380394006349 Coenzyme A binding pocket [chemical binding]; other site 380394006350 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 380394006351 TPR motif; other site 380394006352 binding surface 380394006353 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 380394006354 binding surface 380394006355 TPR motif; other site 380394006356 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 380394006357 binding surface 380394006358 TPR motif; other site 380394006359 Tetratricopeptide repeat; Region: TPR_16; pfam13432 380394006360 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 380394006361 binding surface 380394006362 TPR motif; other site 380394006363 TPR repeat; Region: TPR_11; pfam13414 380394006364 Sulfotransferase family; Region: Sulfotransfer_3; pfam13469 380394006365 Anaerobic ribonucleoside-triphosphate reductase; Region: NRDD; pfam13597 380394006366 Class III ribonucleotide reductase; Region: RNR_III; cd01675 380394006367 effector binding site; other site 380394006368 active site 380394006369 Zn binding site [ion binding]; other site 380394006370 Anaerobic ribonucleoside-triphosphate reductase; Region: NRDD; pfam13597 380394006371 anaerobic ribonucleoside-triphosphate reductase activating protein; Region: NrdG2; TIGR02495 380394006372 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 380394006373 FeS/SAM binding site; other site 380394006374 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 380394006375 Protein of unknown function DUF116; Region: DUF116; cl00800 380394006376 putative protease; Provisional; Region: PRK15447 380394006377 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 380394006378 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 380394006379 DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl07974 380394006380 Peptidase family U32; Region: Peptidase_U32; pfam01136 380394006381 SCP-2 sterol transfer family; Region: SCP2; cl01225 380394006382 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 380394006383 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 380394006384 FMN binding site [chemical binding]; other site 380394006385 substrate binding site [chemical binding]; other site 380394006386 putative catalytic residue [active] 380394006387 Cytochrome c; Region: Cytochrom_C; cl11414 380394006388 Cytochrome c; Region: Cytochrom_C; cl11414 380394006389 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 380394006390 putative oxoacyl-(acyl carrier protein) reductase; Provisional; Region: PRK08945 380394006391 NAD(P) binding site [chemical binding]; other site 380394006392 active site 380394006393 Ubiquitinol-cytochrome C reductase Fe-S subunit TAT signal; Region: UCR_Fe-S_N; pfam10399 380394006394 ubiquinol-cytochrome c reductase, iron-sulfur subunit; Region: Rieske_proteo; TIGR01416 380394006395 Iron-sulfur protein (ISP) component of the bc(1) complex family, Rieske domain; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. The bc(1) complex is a multisubunit enzyme found in many different organisms including...; Region: Rieske_cytochrome_bc1; cd03470 380394006396 [2Fe-2S] cluster binding site [ion binding]; other site 380394006397 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 380394006398 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 380394006399 Qi binding site; other site 380394006400 intrachain domain interface; other site 380394006401 interchain domain interface [polypeptide binding]; other site 380394006402 heme bH binding site [chemical binding]; other site 380394006403 heme bL binding site [chemical binding]; other site 380394006404 Qo binding site; other site 380394006405 interchain domain interface [polypeptide binding]; other site 380394006406 intrachain domain interface; other site 380394006407 Qi binding site; other site 380394006408 Cytochrome b(C-terminal)/b6/petD; Region: Cytochrom_B_C; pfam00032 380394006409 Qo binding site; other site 380394006410 Cytochrome C1 family; Region: Cytochrom_C1; pfam02167 380394006411 Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N; pfam00033 380394006412 23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293 380394006413 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 380394006414 S-adenosylmethionine binding site [chemical binding]; other site 380394006415 Escherichia coli YhbY is associated with pre-50S ribosomal subunits, which implies a function in ribosome assembly; Region: CRS1_YhbY; smart01103 380394006416 CO2+/MG2+ efflux protein ApaG; Reviewed; Region: apaG; PRK05461 380394006417 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 380394006418 S-adenosylmethionine binding site [chemical binding]; other site 380394006419 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 380394006420 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 380394006421 G1 box; other site 380394006422 putative GEF interaction site [polypeptide binding]; other site 380394006423 GTP/Mg2+ binding site [chemical binding]; other site 380394006424 Switch I region; other site 380394006425 G2 box; other site 380394006426 G3 box; other site 380394006427 Switch II region; other site 380394006428 G4 box; other site 380394006429 G5 box; other site 380394006430 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 380394006431 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 380394006432 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 380394006433 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 380394006434 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 380394006435 Protein of unknown function, DUF484; Region: DUF484; cl17449 380394006436 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 380394006437 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 380394006438 active site 380394006439 DNA binding site [nucleotide binding] 380394006440 Int/Topo IB signature motif; other site 380394006441 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 380394006442 active site 380394006443 HslU subunit interaction site [polypeptide binding]; other site 380394006444 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 380394006445 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 380394006446 Walker A motif; other site 380394006447 ATP binding site [chemical binding]; other site 380394006448 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 380394006449 Walker B motif; other site 380394006450 arginine finger; other site 380394006451 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 380394006452 DsrE/DsrF-like family; Region: DrsE; cl00672 380394006453 alternative sigma factor RpoH; Region: rpoH_proteo; TIGR02392 380394006454 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 380394006455 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 380394006456 DNA binding residues [nucleotide binding] 380394006457 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 380394006458 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 380394006459 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 380394006460 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 380394006461 Walker A/P-loop; other site 380394006462 ATP binding site [chemical binding]; other site 380394006463 Q-loop/lid; other site 380394006464 ABC transporter signature motif; other site 380394006465 Walker B; other site 380394006466 D-loop; other site 380394006467 H-loop/switch region; other site 380394006468 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 380394006469 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 380394006470 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 380394006471 P loop; other site 380394006472 GTP binding site [chemical binding]; other site 380394006473 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 380394006474 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 380394006475 S-adenosylmethionine binding site [chemical binding]; other site 380394006476 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 380394006477 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 380394006478 active site 380394006479 (T/H)XGH motif; other site 380394006480 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 380394006481 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 380394006482 Dynamin family; Region: Dynamin_N; pfam00350 380394006483 G1 box; other site 380394006484 GTP/Mg2+ binding site [chemical binding]; other site 380394006485 G2 box; other site 380394006486 Switch I region; other site 380394006487 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 380394006488 G3 box; other site 380394006489 Switch II region; other site 380394006490 GTP/Mg2+ binding site [chemical binding]; other site 380394006491 G4 box; other site 380394006492 G5 box; other site 380394006493 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 380394006494 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 380394006495 DNA binding site [nucleotide binding] 380394006496 catalytic residue [active] 380394006497 H2TH interface [polypeptide binding]; other site 380394006498 putative catalytic residues [active] 380394006499 turnover-facilitating residue; other site 380394006500 intercalation triad [nucleotide binding]; other site 380394006501 8OG recognition residue [nucleotide binding]; other site 380394006502 putative reading head residues; other site 380394006503 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 380394006504 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 380394006505 protein-(glutamine-N5) methyltransferase, release factor-specific; Region: RF_mod_PrmC; TIGR03534 380394006506 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 380394006507 peptide chain release factor 1; Validated; Region: prfA; PRK00591 380394006508 This domain is found in peptide chain release factors; Region: PCRF; smart00937 380394006509 RF-1 domain; Region: RF-1; pfam00472 380394006510 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 380394006511 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 380394006512 tRNA; other site 380394006513 putative tRNA binding site [nucleotide binding]; other site 380394006514 putative NADP binding site [chemical binding]; other site 380394006515 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 380394006516 Tetratricopeptide repeat; Region: TPR_16; pfam13432 380394006517 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 380394006518 TPR motif; other site 380394006519 binding surface 380394006520 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 380394006521 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 380394006522 TPR motif; other site 380394006523 binding surface 380394006524 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 380394006525 binding surface 380394006526 TPR motif; other site 380394006527 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 380394006528 binding surface 380394006529 TPR motif; other site 380394006530 Tetratricopeptide repeat; Region: TPR_16; pfam13432 380394006531 Outer membrane lipoprotein LolB; Region: LolB; pfam03550 380394006532 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00343 380394006533 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 380394006534 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 380394006535 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 380394006536 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 380394006537 active site 380394006538 Restriction endonuclease; Region: Mrr_cat; pfam04471 380394006539 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 380394006540 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 380394006541 oligomeric interface; other site 380394006542 homodimer interface [polypeptide binding]; other site 380394006543 putative active site [active] 380394006544 Virulence-associated protein and related proteins [Function unknown]; Region: VagC; COG4456 380394006545 Domain of unknown function (DUF4338); Region: DUF4338; pfam14236 380394006546 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 380394006547 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880 380394006548 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 380394006549 transposase; Validated; Region: PRK08181 380394006550 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 380394006551 Walker A motif; other site 380394006552 ATP binding site [chemical binding]; other site 380394006553 Integrase core domain; Region: rve; pfam00665 380394006554 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 380394006555 putative transposase OrfB; Reviewed; Region: PHA02517 380394006556 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 380394006557 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 380394006558 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 380394006559 motif II; other site 380394006560 Copper binding periplasmic protein CusF; Region: CusF_Ec; pfam11604 380394006561 Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; cl01768 380394006562 Outer membrane protein family (DUF1597); Region: DUF1597; pfam07642 380394006563 Putative heavy-metal-binding; Region: YbjQ_1; cl00426 380394006564 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 380394006565 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 380394006566 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 380394006567 ATP binding site [chemical binding]; other site 380394006568 putative Mg++ binding site [ion binding]; other site 380394006569 Domain of unknown function (DUF3387); Region: DUF3387; pfam11867 380394006570 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 380394006571 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 380394006572 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 380394006573 HsdM N-terminal domain; Region: HsdM_N; pfam12161 380394006574 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 380394006575 Methyltransferase domain; Region: Methyltransf_26; pfam13659 380394006576 T5orf172 domain; Region: T5orf172; pfam10544 380394006577 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 380394006578 dimerization interface [polypeptide binding]; other site 380394006579 putative DNA binding site [nucleotide binding]; other site 380394006580 putative Zn2+ binding site [ion binding]; other site 380394006581 O-6-alkylguanine-DNA:cysteine-protein methyltransferase; Provisional; Region: PRK10286 380394006582 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 380394006583 DNA binding site [nucleotide binding] 380394006584 active site 380394006585 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 380394006586 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 380394006587 AlkA N-terminal domain; Region: AlkA_N; pfam06029 380394006588 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 380394006589 minor groove reading motif; other site 380394006590 helix-hairpin-helix signature motif; other site 380394006591 active site 380394006592 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_2; cd07253 380394006593 dimer interface [polypeptide binding]; other site 380394006594 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 380394006595 metal binding site [ion binding]; metal-binding site 380394006596 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 380394006597 classical (c) SDRs; Region: SDR_c; cd05233 380394006598 NAD(P) binding site [chemical binding]; other site 380394006599 active site 380394006600 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880 380394006601 Domain of unknown function (DUF4338); Region: DUF4338; pfam14236 380394006602 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 380394006603 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 380394006604 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 380394006605 Predicted flavoprotein [General function prediction only]; Region: COG0431 380394006606 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_4; cd07822 380394006607 putative hydrophobic ligand binding site [chemical binding]; other site 380394006608 Cupin domain; Region: Cupin_2; cl17218 380394006609 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 380394006610 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 380394006611 Putative FMN-binding domain; Region: FMN_bind_2; pfam04299 380394006612 Aminopeptidase P, N-terminal domain; Region: AMP_N; pfam05195 380394006613 proline aminopeptidase P II; Provisional; Region: PRK10879 380394006614 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 380394006615 active site 380394006616 Domain of unknown function (DUF4168); Region: DUF4168; pfam13767 380394006617 DNA repair protein RadA; Provisional; Region: PRK11823 380394006618 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 380394006619 Walker A motif/ATP binding site; other site 380394006620 ATP binding site [chemical binding]; other site 380394006621 Walker B motif; other site 380394006622 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 380394006623 alanine racemase; Reviewed; Region: alr; PRK00053 380394006624 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827 380394006625 active site 380394006626 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 380394006627 substrate binding site [chemical binding]; other site 380394006628 catalytic residues [active] 380394006629 dimer interface [polypeptide binding]; other site 380394006630 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 380394006631 replicative DNA helicase; Region: DnaB; TIGR00665 380394006632 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 380394006633 Walker A motif; other site 380394006634 ATP binding site [chemical binding]; other site 380394006635 Walker B motif; other site 380394006636 DNA binding loops [nucleotide binding] 380394006637 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 380394006638 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 380394006639 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 380394006640 Predicted membrane protein (DUF2232); Region: DUF2232; cl01728 380394006641 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 380394006642 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 380394006643 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 380394006644 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 380394006645 Amino acid permease; Region: AA_permease_2; pfam13520 380394006646 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 380394006647 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 380394006648 23S rRNA m(5)U1939 methyltransferase; Reviewed; Region: rumA; PRK13168 380394006649 TRAM domain; Region: TRAM; cl01282 380394006650 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 380394006651 S-adenosylmethionine binding site [chemical binding]; other site 380394006652 Uncharacterized bacterial subgroup of the DEDDy 3'-5' exonuclease domain of family-B DNA polymerases; Region: DNA_polB_like1_exo; cd05782 380394006653 active site 380394006654 catalytic site [active] 380394006655 substrate binding site [chemical binding]; other site 380394006656 Predicted 3'-5' exonuclease related to the exonuclease domain of PolB; Region: DNA_pol_B_exo2; pfam10108 380394006657 Protein of unknown function (DUF1318); Region: DUF1318; cl01547 380394006658 cysteine synthase B; Region: cysM; TIGR01138 380394006659 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 380394006660 dimer interface [polypeptide binding]; other site 380394006661 pyridoxal 5'-phosphate binding site [chemical binding]; other site 380394006662 catalytic residue [active] 380394006663 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 380394006664 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 380394006665 putative active site [active] 380394006666 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 380394006667 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 380394006668 glycogen branching enzyme; Provisional; Region: PRK05402 380394006669 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 380394006670 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 380394006671 active site 380394006672 catalytic site [active] 380394006673 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 380394006674 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00725 380394006675 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 380394006676 ligand binding site; other site 380394006677 oligomer interface; other site 380394006678 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 380394006679 dimer interface [polypeptide binding]; other site 380394006680 N-terminal domain interface [polypeptide binding]; other site 380394006681 sulfate 1 binding site; other site 380394006682 Catalytic domain of glycoside hydrolase (GH) families 38 and 57, lactam utilization protein LamB/YcsF family proteins, YdjC-family proteins, and similar proteins; Region: GH38-57_N_LamB_YdjC_SF; cl17191 380394006683 N-terminal catalytic domain of thermoactive amylopullulanases; glycoside hydrolase family 57 (GH57); Region: GH57N_APU; cd10796 380394006684 putative active site [active] 380394006685 catalytic site [active] 380394006686 N-terminal catalytic domain of 4-alpha-glucanotransferase; glycoside hydrolase family 57 (GH57); Region: GH57N_TLGT_like; cd10793 380394006687 Glycosyl hydrolase family 57; Region: Glyco_hydro_57; pfam03065 380394006688 active site 380394006689 catalytic site [active] 380394006690 homodimer interface [polypeptide binding]; other site 380394006691 Lid 1; other site 380394006692 Domain of unknown function (DUF1925); Region: DUF1925; pfam09094 380394006693 Domain of unknown function (DUF1926); Region: DUF1926; pfam09095 380394006694 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 380394006695 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 380394006696 nucleotide binding site [chemical binding]; other site 380394006697 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 380394006698 Protein of unknown function (DUF445); Region: DUF445; pfam04286 380394006699 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 380394006700 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 380394006701 dimer interface [polypeptide binding]; other site 380394006702 ssDNA binding site [nucleotide binding]; other site 380394006703 tetramer (dimer of dimers) interface [polypeptide binding]; other site 380394006704 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 380394006705 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 380394006706 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 380394006707 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 380394006708 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 380394006709 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 380394006710 catalytic residues [active] 380394006711 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 380394006712 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 380394006713 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 380394006714 protein binding site [polypeptide binding]; other site 380394006715 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 380394006716 protein binding site [polypeptide binding]; other site 380394006717 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 380394006718 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 380394006719 active site 380394006720 DNA binding site [nucleotide binding] 380394006721 Int/Topo IB signature motif; other site 380394006722 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 380394006723 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 380394006724 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 380394006725 RimM N-terminal domain; Region: RimM; pfam01782 380394006726 PRC-barrel domain; Region: PRC; pfam05239 380394006727 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 380394006728 signal recognition particle protein; Provisional; Region: PRK10867 380394006729 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 380394006730 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 380394006731 P loop; other site 380394006732 GTP binding site [chemical binding]; other site 380394006733 Signal peptide binding domain; Region: SRP_SPB; pfam02978 380394006734 arsenical resistance protein ArsH; Region: resist_ArsH; TIGR02690 380394006735 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 380394006736 arsenical pump membrane protein; Provisional; Region: PRK15445 380394006737 Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118 380394006738 transmembrane helices; other site 380394006739 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 380394006740 dimerization interface [polypeptide binding]; other site 380394006741 putative DNA binding site [nucleotide binding]; other site 380394006742 putative Zn2+ binding site [ion binding]; other site 380394006743 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 380394006744 Low molecular weight phosphatase family; Region: LMWPc; cd00115 380394006745 active site 380394006746 putative efflux pump membrane fusion protein; Provisional; Region: PRK03598 380394006747 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 380394006748 HlyD family secretion protein; Region: HlyD_3; pfam13437 380394006749 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 380394006750 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 380394006751 Walker A/P-loop; other site 380394006752 ATP binding site [chemical binding]; other site 380394006753 Q-loop/lid; other site 380394006754 ABC transporter signature motif; other site 380394006755 Walker B; other site 380394006756 D-loop; other site 380394006757 H-loop/switch region; other site 380394006758 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 380394006759 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 380394006760 Walker A/P-loop; other site 380394006761 ATP binding site [chemical binding]; other site 380394006762 Q-loop/lid; other site 380394006763 ABC transporter signature motif; other site 380394006764 Walker B; other site 380394006765 D-loop; other site 380394006766 H-loop/switch region; other site 380394006767 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 380394006768 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 380394006769 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 380394006770 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 380394006771 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 380394006772 catalytic residues [active] 380394006773 Hemerythrin HHE cation binding domain; Region: Hemerythrin; pfam01814 380394006774 glycine cleavage system protein H; Provisional; Region: PRK13380 380394006775 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 380394006776 lipoyl attachment site [posttranslational modification]; other site 380394006777 Uncharacterized ACR, COG1430; Region: DUF192; pfam02643 380394006778 Transcriptional regulator [Transcription]; Region: LysR; COG0583 380394006779 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 380394006780 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 380394006781 putative effector binding pocket; other site 380394006782 dimerization interface [polypeptide binding]; other site 380394006783 DsrE/DsrF/DrsH-like family; Region: DrsE_2; pfam13686 380394006784 Uncharacterized protein with protein kinase and helix-hairpin-helix DNA-binding domains [General function prediction only]; Region: COG4248 380394006785 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 380394006786 substrate binding site [chemical binding]; other site 380394006787 activation loop (A-loop); other site 380394006788 Protein phosphatase 2C; Region: PP2C_2; pfam13672 380394006789 active site 380394006790 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 380394006791 metal ion-dependent adhesion site (MIDAS); other site 380394006792 Integrase core domain; Region: rve; pfam00665 380394006793 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 380394006794 Fe-S cluster binding site [ion binding]; other site 380394006795 active site 380394006796 Choloylglycine hydrolase (CGH) is a bile salt-modifying enzyme that hydrolyzes non-peptide carbon-nitrogen bonds in choloylglycine and choloyltaurine, both of which are present in bile. CGH is present in a number of probiotic microbial organisms that...; Region: Ntn_CGH; cd01902 380394006797 Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275 380394006798 PemK-like protein; Region: PemK; pfam02452 380394006799 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 380394006800 PIN domains of VapC and Smg6 ribonucleases, ribosome assembly factor NOB1, Archaeoglobus fulgidus AF0591 protein and homologs; Region: PIN_VapC-Smg6-like; cd09855 380394006801 putative active site [active] 380394006802 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 380394006803 Tic20-like protein; Region: Tic20; pfam09685 380394006804 ABC transporter ATPase component; Reviewed; Region: PRK11147 380394006805 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 380394006806 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 380394006807 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 380394006808 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 380394006809 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 380394006810 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 380394006811 O-Antigen ligase; Region: Wzy_C; pfam04932 380394006812 type IV pilus biogenesis/stability protein PilW; Region: type_IV_pilW; TIGR02521 380394006813 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 380394006814 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 380394006815 substrate binding pocket [chemical binding]; other site 380394006816 chain length determination region; other site 380394006817 substrate-Mg2+ binding site; other site 380394006818 catalytic residues [active] 380394006819 aspartate-rich region 1; other site 380394006820 active site lid residues [active] 380394006821 aspartate-rich region 2; other site 380394006822 nitrogen regulation protein NR(I); Region: ntrC; TIGR01818 380394006823 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 380394006824 active site 380394006825 phosphorylation site [posttranslational modification] 380394006826 intermolecular recognition site; other site 380394006827 dimerization interface [polypeptide binding]; other site 380394006828 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 380394006829 Walker A motif; other site 380394006830 ATP binding site [chemical binding]; other site 380394006831 Walker B motif; other site 380394006832 arginine finger; other site 380394006833 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 380394006834 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 380394006835 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 380394006836 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 380394006837 dimer interface [polypeptide binding]; other site 380394006838 phosphorylation site [posttranslational modification] 380394006839 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 380394006840 ATP binding site [chemical binding]; other site 380394006841 Mg2+ binding site [ion binding]; other site 380394006842 G-X-G motif; other site 380394006843 Predicted proteasome-type protease [Posttranslational modification, protein turnover, chaperones]; Region: COG3484 380394006844 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 380394006845 active site 380394006846 Uncharacterized conserved protein [Function unknown]; Region: COG2308 380394006847 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 380394006848 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168 380394006849 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 380394006850 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 380394006851 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 380394006852 Putative amidoligase enzyme (DUF2126); Region: DUF2126; pfam09899 380394006853 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4196 380394006854 PrkA family serine protein kinase; Provisional; Region: PRK15455 380394006855 AAA ATPase domain; Region: AAA_16; pfam13191 380394006856 PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798 380394006857 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 380394006858 hypothetical protein; Provisional; Region: PRK05325 380394006859 SpoVR family protein; Provisional; Region: PRK11767 380394006860 Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719 380394006861 Outer membrane protein family (DUF1597); Region: DUF1597; pfam07642 380394006862 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 380394006863 Nitrogen regulatory protein P-II; Region: P-II; smart00938 380394006864 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 380394006865 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 380394006866 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 380394006867 catalytic triad [active] 380394006868 Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797 380394006869 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 380394006870 Superinfection immunity protein; Region: Imm_superinfect; pfam14373 380394006871 voltage-gated potassium channel; Provisional; Region: PRK10537 380394006872 Ion channel; Region: Ion_trans_2; pfam07885 380394006873 TrkA-N domain; Region: TrkA_N; pfam02254 380394006874 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 380394006875 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 380394006876 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 380394006877 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 380394006878 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 380394006879 active site 380394006880 dimer interface [polypeptide binding]; other site 380394006881 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 380394006882 dimer interface [polypeptide binding]; other site 380394006883 active site 380394006884 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 380394006885 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 380394006886 Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239 380394006887 Uncharacterized ACR, COG1993; Region: DUF190; cl00872 380394006888 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267 380394006889 Uncharacterized protein conserved in archaea [Function unknown]; Region: COG1689 380394006890 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 380394006891 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 380394006892 S-adenosylmethionine binding site [chemical binding]; other site 380394006893 Protein of unknown function (DUF1211); Region: DUF1211; cl01421 380394006894 exonuclease V subunit gamma; Provisional; Region: recC; PRK11069 380394006895 Exodeoxyribonuclease V, gamma subunit; Region: Exonuc_V_gamma; pfam04257 380394006896 exonuclease V subunit beta; Provisional; Region: recB; PRK10876 380394006897 Family description; Region: UvrD_C_2; pfam13538 380394006898 exodeoxyribonuclease V, alpha subunit; Region: recD; TIGR01447 380394006899 AAA domain; Region: AAA_30; pfam13604 380394006900 Family description; Region: UvrD_C_2; pfam13538 380394006901 phosphate regulon transcriptional regulatory protein PhoB; Region: PhoB; TIGR02154 380394006902 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 380394006903 DNA binding site [nucleotide binding] 380394006904 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 380394006905 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 380394006906 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 380394006907 Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N; pfam00033 380394006908 ATPase, P-type (transporting), HAD superfamily, subfamily IC; Region: ATPase_P-type; TIGR01494 380394006909 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 380394006910 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 380394006911 motif II; other site 380394006912 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 380394006913 methionine sulfoxide reductase B; Provisional; Region: PRK00222 380394006914 SelR domain; Region: SelR; pfam01641 380394006915 methionine sulfoxide reductase A; Provisional; Region: PRK14054 380394006916 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 380394006917 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 380394006918 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 380394006919 active site 380394006920 (T/H)XGH motif; other site 380394006921 iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090 380394006922 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 380394006923 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 380394006924 active site 380394006925 dimer interface [polypeptide binding]; other site 380394006926 ribonuclease G; Provisional; Region: PRK11712 380394006927 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 380394006928 homodimer interface [polypeptide binding]; other site 380394006929 oligonucleotide binding site [chemical binding]; other site 380394006930 response regulator GlrR; Provisional; Region: PRK15115 380394006931 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 380394006932 active site 380394006933 phosphorylation site [posttranslational modification] 380394006934 intermolecular recognition site; other site 380394006935 dimerization interface [polypeptide binding]; other site 380394006936 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 380394006937 Walker A motif; other site 380394006938 ATP binding site [chemical binding]; other site 380394006939 Walker B motif; other site 380394006940 arginine finger; other site 380394006941 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 380394006942 dimerization interface [polypeptide binding]; other site 380394006943 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 380394006944 dimer interface [polypeptide binding]; other site 380394006945 phosphorylation site [posttranslational modification] 380394006946 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 380394006947 ATP binding site [chemical binding]; other site 380394006948 Mg2+ binding site [ion binding]; other site 380394006949 G-X-G motif; other site 380394006950 oxidative damage protection protein; Provisional; Region: PRK05408 380394006951 mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479 380394006952 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 380394006953 Substrate binding site; other site 380394006954 Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050 380394006955 polysaccharide export inner-membrane protein, BexC/CtrB/KpsE family; Region: BexC_CtrB_KpsE; TIGR01010 380394006956 Domain of unknown function (DUF4214); Region: DUF4214; pfam13946 380394006957 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 380394006958 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 380394006959 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 380394006960 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 380394006961 Walker A/P-loop; other site 380394006962 ATP binding site [chemical binding]; other site 380394006963 Q-loop/lid; other site 380394006964 ABC transporter signature motif; other site 380394006965 Walker B; other site 380394006966 D-loop; other site 380394006967 H-loop/switch region; other site 380394006968 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 380394006969 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 380394006970 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 380394006971 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 380394006972 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880 380394006973 Domain of unknown function (DUF4338); Region: DUF4338; pfam14236 380394006974 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 380394006975 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 380394006976 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 380394006977 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 380394006978 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 380394006979 Sulfotransferase family; Region: Sulfotransfer_2; pfam03567 380394006980 ubiquinone biosynthesis O-methyltransferase; Region: UbiG; TIGR01983 380394006981 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 380394006982 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 380394006983 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 380394006984 Active Sites [active] 380394006985 bifunctional sulfate adenylyltransferase subunit 1/adenylylsulfate kinase protein; Provisional; Region: PRK05506 380394006986 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 380394006987 CysD dimerization site [polypeptide binding]; other site 380394006988 G1 box; other site 380394006989 putative GEF interaction site [polypeptide binding]; other site 380394006990 GTP/Mg2+ binding site [chemical binding]; other site 380394006991 Switch I region; other site 380394006992 G2 box; other site 380394006993 G3 box; other site 380394006994 Switch II region; other site 380394006995 G4 box; other site 380394006996 G5 box; other site 380394006997 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 380394006998 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 380394006999 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 380394007000 ligand-binding site [chemical binding]; other site 380394007001 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 380394007002 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 380394007003 active site 380394007004 GxGYxY sequence motif in domain of unknown function; Region: GxGYxYP; pfam14323 380394007005 polysaccharide export protein Wza; Provisional; Region: PRK15078 380394007006 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 380394007007 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 380394007008 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 380394007009 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 380394007010 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 380394007011 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 380394007012 NADP-binding site; other site 380394007013 homotetramer interface [polypeptide binding]; other site 380394007014 substrate binding site [chemical binding]; other site 380394007015 homodimer interface [polypeptide binding]; other site 380394007016 active site 380394007017 Methyltransferase domain; Region: Methyltransf_23; pfam13489 380394007018 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 380394007019 S-adenosylmethionine binding site [chemical binding]; other site 380394007020 Methyltransferase domain; Region: Methyltransf_23; pfam13489 380394007021 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 380394007022 S-adenosylmethionine binding site [chemical binding]; other site 380394007023 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 380394007024 PIN domain of the hypothetical protein MT3492 of Mycobacterium tuberculosis CDC1551 and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MT3492; cd09874 380394007025 putative active site [active] 380394007026 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 380394007027 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 380394007028 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 380394007029 Walker A/P-loop; other site 380394007030 ATP binding site [chemical binding]; other site 380394007031 Q-loop/lid; other site 380394007032 ABC transporter signature motif; other site 380394007033 Walker B; other site 380394007034 D-loop; other site 380394007035 H-loop/switch region; other site 380394007036 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 380394007037 Coenzyme A binding pocket [chemical binding]; other site 380394007038 The substrate-binding component of ABC-type thermophilic oligopeptide-binding protein Hb8-like import systems, contains the type 2 periplasmic binding fold; Region: PBP2_thermophilic_Hb8_like; cd08513 380394007039 peptide binding site [polypeptide binding]; other site 380394007040 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 380394007041 dimer interface [polypeptide binding]; other site 380394007042 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 380394007043 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 380394007044 Walker A/P-loop; other site 380394007045 ATP binding site [chemical binding]; other site 380394007046 Q-loop/lid; other site 380394007047 ABC transporter signature motif; other site 380394007048 Walker B; other site 380394007049 D-loop; other site 380394007050 H-loop/switch region; other site 380394007051 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 380394007052 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 380394007053 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 380394007054 Walker A/P-loop; other site 380394007055 ATP binding site [chemical binding]; other site 380394007056 Q-loop/lid; other site 380394007057 ABC transporter signature motif; other site 380394007058 Walker B; other site 380394007059 D-loop; other site 380394007060 H-loop/switch region; other site 380394007061 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 380394007062 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 380394007063 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 380394007064 ABC-ATPase subunit interface; other site 380394007065 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 380394007066 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 380394007067 dimer interface [polypeptide binding]; other site 380394007068 conserved gate region; other site 380394007069 putative PBP binding loops; other site 380394007070 ABC-ATPase subunit interface; other site 380394007071 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 380394007072 The substrate-binding component of ABC-type thermophilic oligopeptide-binding protein Hb8-like import systems, contains the type 2 periplasmic binding fold; Region: PBP2_thermophilic_Hb8_like; cd08513 380394007073 peptide binding site [polypeptide binding]; other site 380394007074 dimer interface [polypeptide binding]; other site 380394007075 Domain of Unknown Function with PDB structure (DUF3857); Region: DUF3857; pfam12969 380394007076 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 380394007077 Domain of Unknown Function with PDB structure (DUF3857); Region: DUF3857; pfam12969 380394007078 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 380394007079 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 380394007080 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 380394007081 Multiple antibiotic transporter [Intracellular trafficking and secretion]; Region: MarC; COG2095 380394007082 malate dehydrogenase; Reviewed; Region: PRK06223 380394007083 NAD-dependent, lactate dehydrogenase-like, 2-hydroxycarboxylate dehydrogenase family; Region: LDH_MDH_like; cl17195 380394007084 NAD(P) binding site [chemical binding]; other site 380394007085 substrate binding site [chemical binding]; other site 380394007086 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 380394007087 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 380394007088 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 380394007089 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 380394007090 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 380394007091 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 380394007092 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 380394007093 Coenzyme A binding pocket [chemical binding]; other site 380394007094 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 380394007095 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 380394007096 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 380394007097 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 380394007098 active site 380394007099 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 380394007100 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 380394007101 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 380394007102 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 380394007103 Enoylreductase; Region: PKS_ER; smart00829 380394007104 NAD(P) binding site [chemical binding]; other site 380394007105 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 380394007106 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 380394007107 putative NADP binding site [chemical binding]; other site 380394007108 active site 380394007109 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 380394007110 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 380394007111 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 380394007112 substrate-cofactor binding pocket; other site 380394007113 pyridoxal 5'-phosphate binding site [chemical binding]; other site 380394007114 catalytic residue [active] 380394007115 Capsule polysaccharide biosynthesis protein; Region: Capsule_synth; pfam05159 380394007116 Capsule polysaccharide export protein [Cell envelope biogenesis, outer membrane]; Region: KpsS; COG3562 380394007117 Capsule polysaccharide biosynthesis protein; Region: Capsule_synth; pfam05159 380394007118 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 380394007119 NAD(P) binding site [chemical binding]; other site 380394007120 active site 380394007121 Sulfatase; Region: Sulfatase; cl17466 380394007122 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 380394007123 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 380394007124 minor groove reading motif; other site 380394007125 helix-hairpin-helix signature motif; other site 380394007126 substrate binding pocket [chemical binding]; other site 380394007127 active site 380394007128 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 380394007129 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 380394007130 DNA binding and oxoG recognition site [nucleotide binding] 380394007131 Uncharacterized protein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: AsmA; COG2982 380394007132 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 380394007133 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 380394007134 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 380394007135 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 380394007136 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 380394007137 regulatory protein interface [polypeptide binding]; other site 380394007138 active site 380394007139 regulatory phosphorylation site [posttranslational modification]; other site 380394007140 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025 380394007141 active site 380394007142 active pocket/dimerization site; other site 380394007143 phosphorylation site [posttranslational modification] 380394007144 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 380394007145 AAA domain; Region: AAA_33; pfam13671 380394007146 HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603 380394007147 Hpr(Ser) kinase/phosphatase; Region: hpr-ser; TIGR00679 380394007148 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 380394007149 Hpr binding site; other site 380394007150 active site 380394007151 homohexamer subunit interaction site [polypeptide binding]; other site 380394007152 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 380394007153 active site 380394007154 phosphorylation site [posttranslational modification] 380394007155 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 380394007156 30S subunit binding site; other site 380394007157 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 380394007158 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 380394007159 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 380394007160 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 380394007161 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 380394007162 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 380394007163 Walker A/P-loop; other site 380394007164 ATP binding site [chemical binding]; other site 380394007165 Q-loop/lid; other site 380394007166 ABC transporter signature motif; other site 380394007167 Walker B; other site 380394007168 D-loop; other site 380394007169 H-loop/switch region; other site 380394007170 lipopolysaccharide transport periplasmic protein LptA; Region: outer_YhbN_LptA; TIGR03002 380394007171 OstA-like protein; Region: OstA; pfam03968 380394007172 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3117; cl01200 380394007173 Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835 380394007174 Low specificity phosphatase (HAD superfamily) [General function prediction only]; Region: COG1778 380394007175 HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662 380394007176 D-arabinose 5-phosphate isomerase; Provisional; Region: gutQ; PRK11543 380394007177 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 380394007178 putative active site [active] 380394007179 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 380394007180 [FeFe] hydrogenase, group B1/B3; Region: FeFe_hydrog_B1; TIGR04105 380394007181 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 380394007182 NTP_transferase_like_1 is a member of the nucleotidyl transferase family; Region: NTP_transferase_like_1; cd06422 380394007183 Substrate binding site; other site 380394007184 metal-binding site 380394007185 Phosphotransferase enzyme family; Region: APH; pfam01636 380394007186 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 380394007187 active site 380394007188 ATP binding site [chemical binding]; other site 380394007189 substrate binding site [chemical binding]; other site 380394007190 LPS assembly outer membrane complex protein LptD; Provisional; Region: PRK03761 380394007191 OstA-like protein; Region: OstA; cl00844 380394007192 Organic solvent tolerance protein; Region: OstA_C; pfam04453 380394007193 peptidyl-prolyl cis-trans isomerase SurA; Provisional; Region: PRK10770 380394007194 SurA N-terminal domain; Region: SurA_N; pfam09312 380394007195 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 380394007196 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 380394007197 ABC-2 type transporter; Region: ABC2_membrane; cl17235 380394007198 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 380394007199 BolA-like protein; Region: BolA; pfam01722 380394007200 Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028 380394007201 putative GSH binding site [chemical binding]; other site 380394007202 catalytic residues [active] 380394007203 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 380394007204 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 380394007205 hinge; other site 380394007206 active site 380394007207 ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686 380394007208 ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040 380394007209 histidinol dehydrogenase; Region: hisD; TIGR00069 380394007210 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 380394007211 NAD binding site [chemical binding]; other site 380394007212 dimerization interface [polypeptide binding]; other site 380394007213 product binding site; other site 380394007214 substrate binding site [chemical binding]; other site 380394007215 zinc binding site [ion binding]; other site 380394007216 catalytic residues [active] 380394007217 histidinol-phosphate aminotransferase; Provisional; Region: PRK04870 380394007218 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 380394007219 pyridoxal 5'-phosphate binding site [chemical binding]; other site 380394007220 homodimer interface [polypeptide binding]; other site 380394007221 catalytic residue [active] 380394007222 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 380394007223 putative active site pocket [active] 380394007224 4-fold oligomerization interface [polypeptide binding]; other site 380394007225 metal binding residues [ion binding]; metal-binding site 380394007226 3-fold/trimer interface [polypeptide binding]; other site 380394007227 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141 380394007228 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 380394007229 putative active site [active] 380394007230 oxyanion strand; other site 380394007231 catalytic triad [active] 380394007232 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 380394007233 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 380394007234 catalytic residues [active] 380394007235 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 380394007236 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 380394007237 substrate binding site [chemical binding]; other site 380394007238 glutamase interaction surface [polypeptide binding]; other site 380394007239 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 380394007240 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 380394007241 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 380394007242 metal binding site [ion binding]; metal-binding site 380394007243 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 380394007244 Sec-independent protein secretion pathway components [Intracellular trafficking and secretion]; Region: TatA; COG1826 380394007245 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 380394007246 ribulose bisophosphate carboxylase; Reviewed; Region: rbcL; PRK04208 380394007247 Ribulose bisphosphate carboxylase large chain; Region: RuBisCO_large; cl08232 380394007248 dimer interface [polypeptide binding]; other site 380394007249 catalytic residue [active] 380394007250 metal binding site [ion binding]; metal-binding site 380394007251 Ribulose bisphosphate carboxylase/oxygenase (Rubisco), small subunit. Rubisco is a bifunctional enzyme catalyzes the initial steps of two opposing metabolic pathways: photosynthetic carbon fixation and the competing process of photorespiration. Rubisco...; Region: RuBisCO_small; cd03527 380394007252 multimerization interface [polypeptide binding]; other site 380394007253 MoxR-like ATPases [General function prediction only]; Region: COG0714 380394007254 AAA domain (dynein-related subfamily); Region: AAA_5; pfam07728 380394007255 CbbQ/NirQ/NorQ C-terminal; Region: CbbQ_C; pfam08406 380394007256 norD type: Denitrifying bacteria contain both membrane bound and periplasmic nitrate reductases. Denitrification plays a major role in completing the nitrogen cycle by converting nitrate or nitrite to nitrogen gas. The pathway for microbial...; Region: vWA_norD_type; cd01454 380394007257 metal ion-dependent adhesion site (MIDAS); other site 380394007258 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 380394007259 GAF domain; Region: GAF; pfam01590 380394007260 PAS domain; Region: PAS_9; pfam13426 380394007261 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 380394007262 putative active site [active] 380394007263 heme pocket [chemical binding]; other site 380394007264 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 380394007265 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 380394007266 metal binding site [ion binding]; metal-binding site 380394007267 active site 380394007268 I-site; other site 380394007269 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 380394007270 dihydroorotase; Validated; Region: pyrC; PRK09357 380394007271 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 380394007272 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 380394007273 active site 380394007274 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 380394007275 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 380394007276 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 380394007277 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 380394007278 active site 380394007279 Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652 380394007280 hypothetical protein; Validated; Region: PRK00228 380394007281 glutathione synthetase; Provisional; Region: PRK05246 380394007282 Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951 380394007283 Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955 380394007284 Glutamate-cysteine ligase; Region: GshA; pfam08886 380394007285 glutamate--cysteine ligase, T. ferrooxidans family; Region: gshA_ferroox; TIGR02049 380394007286 citrate synthase; Provisional; Region: PRK14036 380394007287 Citrate synthase (CS) catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the oxidative citric acid cycle (TCA or Krebs cycle). Peroxisomal CS is involved in the glyoxylate...; Region: citrate_synt_like_1_1; cd06112 380394007288 dimer interface [polypeptide binding]; other site 380394007289 active site 380394007290 citrylCoA binding site [chemical binding]; other site 380394007291 oxalacetate/citrate binding site [chemical binding]; other site 380394007292 coenzyme A binding site [chemical binding]; other site 380394007293 catalytic triad [active] 380394007294 iron-sulfur cluster insertion protein ErpA; Provisional; Region: PRK13623 380394007295 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 380394007296 E3 interaction surface; other site 380394007297 lipoyl attachment site [posttranslational modification]; other site 380394007298 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 380394007299 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 380394007300 E3 interaction surface; other site 380394007301 lipoyl attachment site [posttranslational modification]; other site 380394007302 e3 binding domain; Region: E3_binding; pfam02817 380394007303 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 380394007304 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 380394007305 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 380394007306 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 380394007307 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 380394007308 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 380394007309 alpha subunit interface [polypeptide binding]; other site 380394007310 TPP binding site [chemical binding]; other site 380394007311 heterodimer interface [polypeptide binding]; other site 380394007312 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 380394007313 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182 380394007314 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 380394007315 tetramer interface [polypeptide binding]; other site 380394007316 TPP-binding site [chemical binding]; other site 380394007317 heterodimer interface [polypeptide binding]; other site 380394007318 phosphorylation loop region [posttranslational modification] 380394007319 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 380394007320 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 380394007321 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 380394007322 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 380394007323 23S rRNA interface [nucleotide binding]; other site 380394007324 L3 interface [polypeptide binding]; other site 380394007325 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 380394007326 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 380394007327 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 380394007328 active site 380394007329 HIGH motif; other site 380394007330 dimer interface [polypeptide binding]; other site 380394007331 KMSKS motif; other site 380394007332 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 380394007333 RNA binding surface [nucleotide binding]; other site 380394007334 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 380394007335 plasma-membrane proton-efflux P-type ATPase; Region: ATPase-IIIA_H; TIGR01647 380394007336 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 380394007337 Soluble P-type ATPase [General function prediction only]; Region: COG4087 380394007338 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cl00540 380394007339 tetramerization interface [polypeptide binding]; other site 380394007340 active site 380394007341 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 380394007342 G1 box; other site 380394007343 GTP/Mg2+ binding site [chemical binding]; other site 380394007344 Switch I region; other site 380394007345 G2 box; other site 380394007346 G3 box; other site 380394007347 Switch II region; other site 380394007348 G4 box; other site 380394007349 G5 box; other site 380394007350 voltage-gated potassium channel; Provisional; Region: PRK10537 380394007351 Ion channel; Region: Ion_trans_2; pfam07885 380394007352 TrkA-N domain; Region: TrkA_N; pfam02254 380394007353 DNA polymerase I; Provisional; Region: PRK05755 380394007354 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 380394007355 active site 380394007356 metal binding site 1 [ion binding]; metal-binding site 380394007357 putative 5' ssDNA interaction site; other site 380394007358 metal binding site 3; metal-binding site 380394007359 metal binding site 2 [ion binding]; metal-binding site 380394007360 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 380394007361 putative DNA binding site [nucleotide binding]; other site 380394007362 putative metal binding site [ion binding]; other site 380394007363 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 380394007364 active site 380394007365 substrate binding site [chemical binding]; other site 380394007366 catalytic site [active] 380394007367 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 380394007368 active site 380394007369 DNA binding site [nucleotide binding] 380394007370 catalytic site [active] 380394007371 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 380394007372 Protein of unknown function (DUF2782); Region: DUF2782; pfam11191 380394007373 Homoserine Kinase, type II. Homoserine kinase is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and...; Region: HomoserineK_II; cd05153 380394007374 Phosphotransferase enzyme family; Region: APH; pfam01636 380394007375 putative active site [active] 380394007376 putative substrate binding site [chemical binding]; other site 380394007377 ATP binding site [chemical binding]; other site 380394007378 Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N; pfam00033 380394007379 competence protein ComEA helix-hairpin-helix repeat region; Region: TIGR00426 380394007380 Helix-hairpin-helix motif; Region: HHH; pfam00633 380394007381 DNA-dependent helicase II; Provisional; Region: uvrD; PRK11773 380394007382 Part of AAA domain; Region: AAA_19; pfam13245 380394007383 Family description; Region: UvrD_C_2; pfam13538 380394007384 curved DNA-binding protein CbpA; Provisional; Region: PRK10266 380394007385 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 380394007386 HSP70 interaction site [polypeptide binding]; other site 380394007387 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 380394007388 substrate binding site [polypeptide binding]; other site 380394007389 dimer interface [polypeptide binding]; other site 380394007390 MerR HTH family regulatory protein; Region: MerR_2; pfam13591 380394007391 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cl00309 380394007392 hypothetical protein; Provisional; Region: PRK08609 380394007393 Nucleotidyltransferase (NT) domain of family X DNA Polymerases; Region: NT_POLXc; cd00141 380394007394 active site 380394007395 primer binding site [nucleotide binding]; other site 380394007396 NTP binding site [chemical binding]; other site 380394007397 metal binding triad [ion binding]; metal-binding site 380394007398 Polymerase and Histidinol Phosphatase domain of bacterial polymerase X; Region: PHP_PolX; cd07436 380394007399 active site 380394007400 Cytochrome c; Region: Cytochrom_C; cl11414 380394007401 Cytochrome c; Region: Cytochrom_C; cl11414 380394007402 putative oxoacyl-(acyl carrier protein) reductase; Provisional; Region: PRK08945 380394007403 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 380394007404 NAD(P) binding site [chemical binding]; other site 380394007405 active site 380394007406 Ubiquitinol-cytochrome C reductase Fe-S subunit TAT signal; Region: UCR_Fe-S_N; pfam10399 380394007407 ubiquinol-cytochrome c reductase, iron-sulfur subunit; Region: Rieske_proteo; TIGR01416 380394007408 Iron-sulfur protein (ISP) component of the bc(1) complex family, Rieske domain; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. The bc(1) complex is a multisubunit enzyme found in many different organisms including...; Region: Rieske_cytochrome_bc1; cd03470 380394007409 [2Fe-2S] cluster binding site [ion binding]; other site 380394007410 cytochrome b; Provisional; Region: CYTB; MTH00145 380394007411 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284 380394007412 Qi binding site; other site 380394007413 intrachain domain interface; other site 380394007414 interchain domain interface [polypeptide binding]; other site 380394007415 heme bH binding site [chemical binding]; other site 380394007416 heme bL binding site [chemical binding]; other site 380394007417 Qo binding site; other site 380394007418 interchain domain interface [polypeptide binding]; other site 380394007419 intrachain domain interface; other site 380394007420 Qi binding site; other site 380394007421 Cytochrome b(C-terminal)/b6/petD; Region: Cytochrom_B_C; pfam00032 380394007422 Qo binding site; other site 380394007423 Cytochrome C1 family; Region: Cytochrom_C1; pfam02167 380394007424 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125 380394007425 ResB-like family; Region: ResB; pfam05140 380394007426 cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144 380394007427 DsrE/DsrF/DrsH-like family; Region: DrsE_2; cl17453 380394007428 Predicted membrane protein [Function unknown]; Region: COG3431 380394007429 DsrE/DsrF/DrsH-like family; Region: DrsE_2; cl17453 380394007430 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 380394007431 CPxP motif; other site 380394007432 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 380394007433 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 380394007434 Protein of unknown function (DUF2818); Region: DUF2818; pfam10993 380394007435 sulfite reductase [NADPH] flavoprotein, alpha-component; Region: cysJ; TIGR01931 380394007436 Flavodoxin; Region: Flavodoxin_1; pfam00258 380394007437 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199 380394007438 FAD binding pocket [chemical binding]; other site 380394007439 FAD binding motif [chemical binding]; other site 380394007440 catalytic residues [active] 380394007441 NAD binding pocket [chemical binding]; other site 380394007442 phosphate binding motif [ion binding]; other site 380394007443 beta-alpha-beta structure motif; other site 380394007444 sulfite reductase subunit beta; Provisional; Region: PRK13504 380394007445 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 380394007446 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 380394007447 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 380394007448 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 380394007449 Active Sites [active] 380394007450 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 380394007451 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 380394007452 Active Sites [active] 380394007453 GTPases - Sulfate adenylate transferase subunit 1 [Inorganic ion transport and metabolism]; Region: CysN; COG2895 380394007454 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 380394007455 CysD dimerization site [polypeptide binding]; other site 380394007456 G1 box; other site 380394007457 putative GEF interaction site [polypeptide binding]; other site 380394007458 GTP/Mg2+ binding site [chemical binding]; other site 380394007459 Switch I region; other site 380394007460 G2 box; other site 380394007461 G3 box; other site 380394007462 Switch II region; other site 380394007463 G4 box; other site 380394007464 G5 box; other site 380394007465 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 380394007466 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 380394007467 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 380394007468 active site 380394007469 SAM binding site [chemical binding]; other site 380394007470 homodimer interface [polypeptide binding]; other site 380394007471 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 380394007472 putative active site [active] 380394007473 OsmC-like protein; Region: OsmC; pfam02566 380394007474 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 380394007475 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 380394007476 Cl- selectivity filter; other site 380394007477 Cl- binding residues [ion binding]; other site 380394007478 pore gating glutamate residue; other site 380394007479 dimer interface [polypeptide binding]; other site 380394007480 twin arginine translocase protein A; Provisional; Region: tatA; PRK02958 380394007481 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 380394007482 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 380394007483 phosphorylation site [posttranslational modification] 380394007484 dimer interface [polypeptide binding]; other site 380394007485 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 380394007486 ATP binding site [chemical binding]; other site 380394007487 Mg2+ binding site [ion binding]; other site 380394007488 G-X-G motif; other site 380394007489 Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain [Signal transduction mechanisms / Transcription]; Region: COG4567 380394007490 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 380394007491 active site 380394007492 phosphorylation site [posttranslational modification] 380394007493 intermolecular recognition site; other site 380394007494 dimerization interface [polypeptide binding]; other site 380394007495 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 380394007496 Prolyl 4-hydroxylase alpha subunit homologues; Region: P4Hc; smart00702 380394007497 Rrf2 family protein; Region: rrf2_super; TIGR00738 380394007498 Transcriptional regulator; Region: Rrf2; pfam02082 380394007499 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 380394007500 Major Facilitator Superfamily; Region: MFS_1; pfam07690 380394007501 putative substrate translocation pore; other site 380394007502 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 380394007503 UbiA prenyltransferase family; Region: UbiA; pfam01040 380394007504 rusticyanin; Region: rusti_cyanin; TIGR03095 380394007505 Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115 380394007506 Heme-copper oxidase subunit I. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane. The superfamily is...; Region: Heme_Cu_Oxidase_I; cd00919 380394007507 D-pathway; other site 380394007508 Low-spin heme binding site [chemical binding]; other site 380394007509 Putative water exit pathway; other site 380394007510 Binuclear center (active site) [active] 380394007511 K-pathway; other site 380394007512 Putative proton exit pathway; other site 380394007513 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 380394007514 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 380394007515 Cytochrome c; Region: Cytochrom_C; cl11414 380394007516 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 380394007517 Cytochrome c; Region: Cytochrom_C; cl11414 380394007518 Cytochrome c [Energy production and conversion]; Region: COG3258 380394007519 heat shock protein 90; Provisional; Region: PRK05218 380394007520 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 380394007521 ATP binding site [chemical binding]; other site 380394007522 Mg2+ binding site [ion binding]; other site 380394007523 G-X-G motif; other site 380394007524 Protein of unknown function (DUF2934); Region: DUF2934; pfam11154 380394007525 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 380394007526 D-Lactate and related Dehydrogenases, NAD-binding and catalytic domains; Region: LDH_like_2; cd12183 380394007527 putative ligand binding site [chemical binding]; other site 380394007528 putative NAD binding site [chemical binding]; other site 380394007529 catalytic site [active] 380394007530 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 380394007531 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 380394007532 Coenzyme A binding pocket [chemical binding]; other site 380394007533 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 380394007534 isochorismate-pyruvate lyase; Reviewed; Region: PRK07075 380394007535 ABC-type transport system involved in cytochrome c biogenesis, ATPase component [Posttranslational modification, protein turnover, chaperones]; Region: CcmA; COG4133 380394007536 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 380394007537 Walker A/P-loop; other site 380394007538 ATP binding site [chemical binding]; other site 380394007539 Q-loop/lid; other site 380394007540 ABC transporter signature motif; other site 380394007541 Walker B; other site 380394007542 D-loop; other site 380394007543 Histone acetyltransferase HPA2 and related acetyltransferases [Transcription / General function prediction only]; Region: WecD; COG0454 380394007544 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 380394007545 Coenzyme A binding pocket [chemical binding]; other site 380394007546 Putative FMN-binding domain; Region: FMN_bind_2; pfam04299 380394007547 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 380394007548 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 380394007549 Cupin domain; Region: Cupin_2; cl17218 380394007550 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_4; cd07822 380394007551 putative hydrophobic ligand binding site [chemical binding]; other site 380394007552 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 380394007553 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_2; cd07253 380394007554 dimer interface [polypeptide binding]; other site 380394007555 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 380394007556 metal binding site [ion binding]; metal-binding site 380394007557 PIN domain; Region: PIN_2; pfam10130 380394007558 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 380394007559 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880 380394007560 Domain of unknown function (DUF4338); Region: DUF4338; pfam14236 380394007561 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 380394007562 transposase; Validated; Region: PRK08181 380394007563 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 380394007564 Walker A motif; other site 380394007565 ATP binding site [chemical binding]; other site 380394007566 Integrase core domain; Region: rve; pfam00665 380394007567 Transposase; Region: DEDD_Tnp_IS110; pfam01548 380394007568 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 380394007569 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 380394007570 Restriction endonuclease [Defense mechanisms]; Region: Mrr; COG1715 380394007571 Mrr N-terminal domain; Region: Mrr_N; pfam14338 380394007572 Restriction endonuclease; Region: Mrr_cat; pfam04471 380394007573 Domain of unknown function (DUF4338); Region: DUF4338; pfam14236 380394007574 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 380394007575 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880 380394007576 Type III restriction enzyme, res subunit; Region: ResIII; pfam04851 380394007577 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 380394007578 Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189 380394007579 DNA methylase; Region: N6_N4_Mtase; pfam01555 380394007580 Repeats in polycystic kidney disease 1 (PKD1) and other proteins; Region: PKD; smart00089 380394007581 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 380394007582 Divergent AAA domain; Region: AAA_4; pfam04326 380394007583 ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749 380394007584 Domain of unknown function (DUF4338); Region: DUF4338; pfam14236 380394007585 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 380394007586 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880 380394007587 AAA domain; Region: AAA_22; pfam13401 380394007588 Integrase core domain; Region: rve; pfam00665 380394007589 TnsA endonuclease N terminal; Region: Tn7_Tnp_TnsA_N; pfam08722 380394007590 TnsA endonuclease C terminal; Region: Tn7_Tnp_TnsA_C; pfam08721 380394007591 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 380394007592 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 380394007593 glutaminase active site [active] 380394007594 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 380394007595 dimer interface [polypeptide binding]; other site 380394007596 active site 380394007597 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 380394007598 dimer interface [polypeptide binding]; other site 380394007599 active site 380394007600 N-acetylglucosamine-1-phosphate uridyltransferase (contains nucleotidyltransferase and I-patch acetyltransferase domains) [Cell envelope biogenesis, outer membrane]; Region: GlmU; COG1207 380394007601 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 380394007602 Substrate binding site; other site 380394007603 Mg++ binding site; other site 380394007604 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 380394007605 active site 380394007606 substrate binding site [chemical binding]; other site 380394007607 CoA binding site [chemical binding]; other site 380394007608 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 380394007609 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 380394007610 gamma subunit interface [polypeptide binding]; other site 380394007611 epsilon subunit interface [polypeptide binding]; other site 380394007612 LBP interface [polypeptide binding]; other site 380394007613 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 380394007614 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 380394007615 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 380394007616 alpha subunit interaction interface [polypeptide binding]; other site 380394007617 Walker A motif; other site 380394007618 ATP binding site [chemical binding]; other site 380394007619 Walker B motif; other site 380394007620 inhibitor binding site; inhibition site 380394007621 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 380394007622 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 380394007623 core domain interface [polypeptide binding]; other site 380394007624 delta subunit interface [polypeptide binding]; other site 380394007625 epsilon subunit interface [polypeptide binding]; other site 380394007626 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 380394007627 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 380394007628 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 380394007629 beta subunit interaction interface [polypeptide binding]; other site 380394007630 Walker A motif; other site 380394007631 ATP binding site [chemical binding]; other site 380394007632 Walker B motif; other site 380394007633 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 380394007634 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 380394007635 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 380394007636 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 380394007637 ATP synthase, F0 subunit b; Region: ATP_synt_b; TIGR01144 380394007638 F0F1 ATP synthase subunit C; Validated; Region: PRK06876 380394007639 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 380394007640 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 380394007641 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 380394007642 ParB-like nuclease domain; Region: ParBc; pfam02195 380394007643 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 380394007644 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 380394007645 P-loop; other site 380394007646 Magnesium ion binding site [ion binding]; other site 380394007647 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 380394007648 Magnesium ion binding site [ion binding]; other site 380394007649 rRNA small subunit methyltransferase G; Region: GidB; pfam02527 380394007650 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 380394007651 S-adenosylmethionine binding site [chemical binding]; other site 380394007652 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 380394007653 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 380394007654 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 380394007655 NlpE N-terminal domain; Region: NlpE; pfam04170 380394007656 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 380394007657 S-adenosylmethionine binding site [chemical binding]; other site 380394007658 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 380394007659 MPT binding site; other site 380394007660 trimer interface [polypeptide binding]; other site 380394007661 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 380394007662 uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827 380394007663 Cl binding site [ion binding]; other site 380394007664 oligomer interface [polypeptide binding]; other site 380394007665 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 380394007666 uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827 380394007667 Cl binding site [ion binding]; other site 380394007668 oligomer interface [polypeptide binding]; other site 380394007669 metal ion transporter CorA-like divalent cation transporter superfamily; Region: MIT_CorA-like; cl00459 380394007670 oligomer interface [polypeptide binding]; other site 380394007671 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 380394007672 uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827 380394007673 Cl binding site [ion binding]; other site 380394007674 oligomer interface [polypeptide binding]; other site 380394007675 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747 380394007676 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 380394007677 Pirin-related protein [General function prediction only]; Region: COG1741 380394007678 Pirin; Region: Pirin; pfam02678 380394007679 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 380394007680 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 380394007681 Protein of unknown function (DUF541); Region: SIMPL; cl01077 380394007682 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 380394007683 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 380394007684 Uncharacterized conserved protein [Function unknown]; Region: COG3391 380394007685 acid phosphatase, Burkholderia-type; Region: acid_phos_Burk; TIGR03397 380394007686 ABC-2 type transporter; Region: ABC2_membrane; cl17235 380394007687 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 380394007688 nodulation ABC transporter NodI; Provisional; Region: PRK13537 380394007689 ATP-binding cassette domain of the lipid transporters, subfamily A; Region: ABC_subfamily_A; cd03263 380394007690 Walker A/P-loop; other site 380394007691 ATP binding site [chemical binding]; other site 380394007692 Q-loop/lid; other site 380394007693 ABC transporter signature motif; other site 380394007694 Walker B; other site 380394007695 D-loop; other site 380394007696 H-loop/switch region; other site 380394007697 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 380394007698 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 380394007699 dimer interface [polypeptide binding]; other site 380394007700 [2Fe-2S] cluster binding site [ion binding]; other site 380394007701 Demethoxyubiquinone hydroxylase, ferritin-like diiron-binding domain; Region: DMQH; cd01042 380394007702 diiron binding motif [ion binding]; other site 380394007703 Rrf2 family protein; Region: rrf2_super; TIGR00738 380394007704 Transcriptional regulator; Region: Rrf2; pfam02082 380394007705 OsmC-like protein; Region: OsmC; cl00767 380394007706 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 380394007707 active site 380394007708 ribulose/triose binding site [chemical binding]; other site 380394007709 phosphate binding site [ion binding]; other site 380394007710 substrate (anthranilate) binding pocket [chemical binding]; other site 380394007711 product (indole) binding pocket [chemical binding]; other site 380394007712 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 380394007713 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 380394007714 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 380394007715 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 380394007716 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 380394007717 glutamine binding [chemical binding]; other site 380394007718 catalytic triad [active] 380394007719 anthranilate synthase component I; Provisional; Region: PRK13565 380394007720 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 380394007721 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 380394007722 2-phosphoglycolate phosphatase, prokaryotic; Region: PGP_bact; TIGR01449 380394007723 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 380394007724 motif II; other site 380394007725 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 380394007726 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 380394007727 substrate binding site [chemical binding]; other site 380394007728 hexamer interface [polypeptide binding]; other site 380394007729 metal binding site [ion binding]; metal-binding site 380394007730 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 380394007731 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 380394007732 intersubunit interface [polypeptide binding]; other site 380394007733 active site 380394007734 zinc binding site [ion binding]; other site 380394007735 Na+ binding site [ion binding]; other site 380394007736 pyruvate kinase; Provisional; Region: PRK05826 380394007737 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 380394007738 domain interfaces; other site 380394007739 active site 380394007740 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 380394007741 Phosphoglycerate kinase; Region: PGK; pfam00162 380394007742 substrate binding site [chemical binding]; other site 380394007743 hinge regions; other site 380394007744 ADP binding site [chemical binding]; other site 380394007745 catalytic site [active] 380394007746 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 380394007747 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 380394007748 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 380394007749 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 380394007750 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 380394007751 TPP-binding site [chemical binding]; other site 380394007752 dimer interface [polypeptide binding]; other site 380394007753 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 380394007754 PYR/PP interface [polypeptide binding]; other site 380394007755 dimer interface [polypeptide binding]; other site 380394007756 TPP binding site [chemical binding]; other site 380394007757 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 380394007758 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 380394007759 putative active site [active] 380394007760 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 380394007761 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 380394007762 active site 380394007763 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 380394007764 RNA methyltransferase, RsmE family; Region: TIGR00046 380394007765 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 380394007766 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 380394007767 RmuC family; Region: RmuC; pfam02646 380394007768 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 380394007769 Large-conductance mechanosensitive channel, MscL; Region: MscL; cl00860 380394007770 Uncharacterized protein family UPF0547; Region: UPF0547; pfam10571 380394007771 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 380394007772 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 380394007773 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 380394007774 HlyD family secretion protein; Region: HlyD_3; pfam13437 380394007775 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 380394007776 Uncharacterized BCR, YaiI/YqxD family COG1671; Region: DUF188; pfam02639 380394007777 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 380394007778 PIN domain; Region: PIN_3; cl17397 380394007779 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 380394007780 ATP binding site [chemical binding]; other site 380394007781 Mg2+ binding site [ion binding]; other site 380394007782 G-X-G motif; other site 380394007783 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 380394007784 dimer interface [polypeptide binding]; other site 380394007785 osmolarity response regulator; Provisional; Region: ompR; PRK09468 380394007786 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 380394007787 active site 380394007788 phosphorylation site [posttranslational modification] 380394007789 intermolecular recognition site; other site 380394007790 dimerization interface [polypeptide binding]; other site 380394007791 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 380394007792 DNA binding site [nucleotide binding] 380394007793 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 380394007794 dimerization interface [polypeptide binding]; other site 380394007795 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 380394007796 dimer interface [polypeptide binding]; other site 380394007797 phosphorylation site [posttranslational modification] 380394007798 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 380394007799 ATP binding site [chemical binding]; other site 380394007800 Mg2+ binding site [ion binding]; other site 380394007801 G-X-G motif; other site 380394007802 argininosuccinate lyase; Provisional; Region: PRK00855 380394007803 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 380394007804 active sites [active] 380394007805 tetramer interface [polypeptide binding]; other site 380394007806 diaminopimelate decarboxylase; Region: lysA; TIGR01048 380394007807 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 380394007808 active site 380394007809 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 380394007810 substrate binding site [chemical binding]; other site 380394007811 catalytic residues [active] 380394007812 dimer interface [polypeptide binding]; other site 380394007813 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 380394007814 substrate binding site [chemical binding]; other site 380394007815 Endopeptidases belonging to membrane-bound hydrogenases group. These hydrogenases transfer electrons from H2 to a cytochrome that is bound to a membrane-located complex coupling electron transfer to transmembrane proton translocation. Endopeptidase HybD...; Region: H2MP_MemB-H2up; cd06062 380394007816 coenzyme F420-reducing hydrogenase delta subunit (putative coenzyme F420 hydrogenase processing subunit); Region: frhD; TIGR00130 380394007817 putative substrate-binding site; other site 380394007818 nickel binding site [ion binding]; other site 380394007819 HupH hydrogenase expression protein, C-terminal conserved region; Region: HupH_C; pfam04809 380394007820 Ni,Fe-hydrogenase I small subunit [Energy production and conversion]; Region: HyaA; COG1740 380394007821 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 380394007822 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 380394007823 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 380394007824 Cysteine-rich domain; Region: CCG; pfam02754 380394007825 Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374 380394007826 Nickel-dependent hydrogenase; Region: NiFeSe_Hases; pfam00374 380394007827 Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) [General function prediction only]; Region: HybF; COG0375 380394007828 Hydrogenase expression/synthesis hypA family; Region: HypA; cl17671 380394007829 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 380394007830 HupF/HypC family; Region: HupF_HypC; pfam01455 380394007831 hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062 380394007832 hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075 380394007833 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 380394007834 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 380394007835 NADP-binding site; other site 380394007836 homotetramer interface [polypeptide binding]; other site 380394007837 substrate binding site [chemical binding]; other site 380394007838 homodimer interface [polypeptide binding]; other site 380394007839 active site 380394007840 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 380394007841 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 380394007842 NADP-binding site; other site 380394007843 homotetramer interface [polypeptide binding]; other site 380394007844 substrate binding site [chemical binding]; other site 380394007845 homodimer interface [polypeptide binding]; other site 380394007846 active site 380394007847 mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479 380394007848 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 380394007849 Substrate binding site; other site 380394007850 Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050 380394007851 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; cl17405 380394007852 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 380394007853 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 380394007854 substrate binding site; other site 380394007855 tetramer interface; other site 380394007856 benzoate transport; Region: 2A0115; TIGR00895 380394007857 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 380394007858 putative substrate translocation pore; other site 380394007859 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 380394007860 TonB C terminal; Region: TonB_2; pfam13103 380394007861 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 380394007862 dimer interface [polypeptide binding]; other site 380394007863 active site 380394007864 Schiff base residues; other site 380394007865 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 380394007866 uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928 380394007867 active site 380394007868 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 380394007869 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 380394007870 domain interfaces; other site 380394007871 active site 380394007872 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 380394007873 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 380394007874 nucleotide binding site/active site [active] 380394007875 HIT family signature motif; other site 380394007876 catalytic residue [active] 380394007877 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 380394007878 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 380394007879 inhibitor-cofactor binding pocket; inhibition site 380394007880 pyridoxal 5'-phosphate binding site [chemical binding]; other site 380394007881 catalytic residue [active] 380394007882 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 380394007883 thiamine phosphate binding site [chemical binding]; other site 380394007884 active site 380394007885 pyrophosphate binding site [ion binding]; other site 380394007886 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 380394007887 dimer interface [polypeptide binding]; other site 380394007888 substrate binding site [chemical binding]; other site 380394007889 ATP binding site [chemical binding]; other site 380394007890 short chain dehydrogenase; Provisional; Region: PRK07024 380394007891 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 380394007892 NAD(P) binding site [chemical binding]; other site 380394007893 active site