-- dump date 20140618_185818 -- class Genbank::misc_feature -- table misc_feature_note -- id note 62977000001 DnaA N-terminal domain; Region: DnaA_N; pfam11638 62977000002 chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362 62977000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 62977000004 Walker A motif; other site 62977000005 ATP binding site [chemical binding]; other site 62977000006 Walker B motif; other site 62977000007 arginine finger; other site 62977000008 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 62977000009 DnaA box-binding interface [nucleotide binding]; other site 62977000010 DNA polymerase III subunit beta; Validated; Region: PRK05643 62977000011 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 62977000012 putative DNA binding surface [nucleotide binding]; other site 62977000013 dimer interface [polypeptide binding]; other site 62977000014 beta-clamp/clamp loader binding surface; other site 62977000015 beta-clamp/translesion DNA polymerase binding surface; other site 62977000016 recombination protein F; Reviewed; Region: recF; PRK00064 62977000017 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 62977000018 Walker A/P-loop; other site 62977000019 ATP binding site [chemical binding]; other site 62977000020 Q-loop/lid; other site 62977000021 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 62977000022 ABC transporter signature motif; other site 62977000023 Walker B; other site 62977000024 D-loop; other site 62977000025 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 62977000026 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 62977000027 Mg2+ binding site [ion binding]; other site 62977000028 G-X-G motif; other site 62977000029 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 62977000030 anchoring element; other site 62977000031 dimer interface [polypeptide binding]; other site 62977000032 ATP binding site [chemical binding]; other site 62977000033 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 62977000034 active site 62977000035 putative metal-binding site [ion binding]; other site 62977000036 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 62977000037 Uncharacterized protein conserved in bacteria (DUF2171); Region: DUF2171; pfam09939 62977000038 putative ABC transporter ATP-binding protein; Provisional; Region: PRK10636 62977000039 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 62977000040 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 62977000041 ABC transporter; Region: ABC_tran_2; pfam12848 62977000042 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 62977000043 iron-sulfur cluster insertion protein ErpA; Provisional; Region: PRK13623 62977000044 anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585 62977000045 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 62977000046 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 62977000047 active site 62977000048 HIGH motif; other site 62977000049 dimer interface [polypeptide binding]; other site 62977000050 KMSKS motif; other site 62977000051 NAD pyrophosphatase/5'-nucleotidase NadN; Region: nadN; TIGR01530 62977000052 CD73 ecto-5'-nucleotidase and related proteins, N-terminal metallophosphatase domain; Region: MPP_CD73_N; cd07409 62977000053 active site 62977000054 metal binding site [ion binding]; metal-binding site 62977000055 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 62977000056 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 62977000057 GST_N family, unknown subfamily 4; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_4; cd03056 62977000058 putative C-terminal domain interface [polypeptide binding]; other site 62977000059 putative GSH binding site (G-site) [chemical binding]; other site 62977000060 putative dimer interface [polypeptide binding]; other site 62977000061 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 62977000062 dimer interface [polypeptide binding]; other site 62977000063 N-terminal domain interface [polypeptide binding]; other site 62977000064 substrate binding pocket (H-site) [chemical binding]; other site 62977000065 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 62977000066 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 62977000067 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 62977000068 Predicted flavoprotein [General function prediction only]; Region: COG0431 62977000069 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 62977000070 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 62977000071 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095 62977000072 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 62977000073 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 62977000074 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 62977000075 active site 62977000076 HIGH motif; other site 62977000077 nucleotide binding site [chemical binding]; other site 62977000078 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 62977000079 active site 62977000080 KMSKS motif; other site 62977000081 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 62977000082 tRNA binding surface [nucleotide binding]; other site 62977000083 anticodon binding site; other site 62977000084 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 62977000085 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 62977000086 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 62977000087 active site 62977000088 Riboflavin kinase; Region: Flavokinase; smart00904 62977000089 Tellurite resistance protein and related permeases [Inorganic ion transport and metabolism]; Region: TehA; COG1275 62977000090 Tellurite-resistance/Dicarboxylate Transporter (TDT) family includes sulfite sensitivity protein (sulfite efflux pump; SSU1); Region: TDT_SSU1; cd09318 62977000091 gating phenylalanine in ion channel; other site 62977000092 pyrimidine utilization protein D; Region: RutD; TIGR03611 62977000093 pyrimidine utilization regulatory protein R; Region: RutR; TIGR03613 62977000094 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 62977000095 YcdC-like protein, C-terminal region; Region: TetR_C_3; pfam08362 62977000096 pyrimidine utilization protein A; Region: RutA; TIGR03612 62977000097 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 62977000098 active site 62977000099 dimer interface [polypeptide binding]; other site 62977000100 non-prolyl cis peptide bond; other site 62977000101 insertion regions; other site 62977000102 Isochorismatase family; Region: Isochorismatase; pfam00857 62977000103 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 62977000104 catalytic triad [active] 62977000105 conserved cis-peptide bond; other site 62977000106 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 62977000107 homotrimer interaction site [polypeptide binding]; other site 62977000108 putative active site [active] 62977000109 pyrimidine utilization flavin reductase protein F; Region: RutF; TIGR03615 62977000110 pyrimidine utilization transport protein G; Region: RutG; TIGR03616 62977000111 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 62977000112 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 62977000113 aliphatic sulfonates transport ATP-binding subunit; Provisional; Region: ssuB; PRK11247 62977000114 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 62977000115 Walker A/P-loop; other site 62977000116 ATP binding site [chemical binding]; other site 62977000117 Q-loop/lid; other site 62977000118 ABC transporter signature motif; other site 62977000119 Walker B; other site 62977000120 D-loop; other site 62977000121 H-loop/switch region; other site 62977000122 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 62977000123 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 62977000124 putative PBP binding loops; other site 62977000125 dimer interface [polypeptide binding]; other site 62977000126 ABC-ATPase subunit interface; other site 62977000127 alkanesulfonate monooxygenase; Provisional; Region: PRK00719 62977000128 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 62977000129 active site 62977000130 dimer interface [polypeptide binding]; other site 62977000131 non-prolyl cis peptide bond; other site 62977000132 insertion regions; other site 62977000133 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 62977000134 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 62977000135 substrate binding pocket [chemical binding]; other site 62977000136 membrane-bound complex binding site; other site 62977000137 hinge residues; other site 62977000138 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 62977000139 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 62977000140 substrate binding pocket [chemical binding]; other site 62977000141 membrane-bound complex binding site; other site 62977000142 hinge residues; other site 62977000143 N-acetylglutamate synthase; Validated; Region: PRK05279 62977000144 AAK_NAGS-ABP: N-acetylglutamate (NAG) kinase-like domain of the NAG Synthase (NAGS) of the arginine-biosynthesis pathway (ABP) found in gamma- and beta-proteobacteria and higher plant chloroplasts. Domain architecture of these NAGS consisted of an...; Region: AAK_NAGS-ABP; cd04237 62977000145 putative feedback inhibition sensing region; other site 62977000146 putative nucleotide binding site [chemical binding]; other site 62977000147 putative substrate binding site [chemical binding]; other site 62977000148 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 62977000149 Coenzyme A binding pocket [chemical binding]; other site 62977000150 Domain of unknown function (DUF3315); Region: DUF3315; pfam11776 62977000151 Domain of unknown function (DUF3315); Region: DUF3315; pfam11776 62977000152 putative oxoacyl-(acyl carrier protein) reductase; Provisional; Region: PRK08945 62977000153 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 62977000154 NAD(P) binding site [chemical binding]; other site 62977000155 active site 62977000156 phosphoglycolate phosphatase; Provisional; Region: PRK13222 62977000157 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 62977000158 active site 62977000159 motif I; other site 62977000160 motif II; other site 62977000161 bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134 62977000162 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 62977000163 S-adenosylmethionine binding site [chemical binding]; other site 62977000164 DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019 62977000165 catalytic residues [active] 62977000166 hinge region; other site 62977000167 alpha helical domain; other site 62977000168 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 62977000169 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 62977000170 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 62977000171 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 62977000172 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_2; cd06216 62977000173 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 62977000174 FAD binding pocket [chemical binding]; other site 62977000175 FAD binding motif [chemical binding]; other site 62977000176 phosphate binding motif [ion binding]; other site 62977000177 beta-alpha-beta structure motif; other site 62977000178 NAD binding pocket [chemical binding]; other site 62977000179 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 62977000180 catalytic loop [active] 62977000181 iron binding site [ion binding]; other site 62977000182 Fatty acid desaturase; Region: FA_desaturase; pfam00487 62977000183 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 62977000184 putative di-iron ligands [ion binding]; other site 62977000185 ribonuclease PH; Reviewed; Region: rph; PRK00173 62977000186 Ribonuclease PH; Region: RNase_PH_bact; cd11362 62977000187 hexamer interface [polypeptide binding]; other site 62977000188 active site 62977000189 PAAR motif; Region: PAAR_motif; pfam05488 62977000190 PAAR motif; Region: PAAR_motif; pfam05488 62977000191 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 62977000192 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 62977000193 quinolinate phosphoribosyltransferase; Validated; Region: PRK09016 62977000194 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 62977000195 dimerization interface [polypeptide binding]; other site 62977000196 active site 62977000197 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 62977000198 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 62977000199 amidase catalytic site [active] 62977000200 substrate binding site [chemical binding]; other site 62977000201 Zn binding residues [ion binding]; other site 62977000202 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 62977000203 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 62977000204 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 62977000205 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 62977000206 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 62977000207 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 62977000208 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 62977000209 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 62977000210 exopolysaccharide transport protein family; Region: eps_transp_fam; TIGR01005 62977000211 Chain length determinant protein; Region: Wzz; pfam02706 62977000212 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 62977000213 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 62977000214 Low molecular weight phosphatase family; Region: LMWPc; cd00115 62977000215 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 62977000216 active site 62977000217 polysaccharide export protein Wza; Provisional; Region: PRK15078 62977000218 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 62977000219 UDP-glucose 6-dehydrogenase; Provisional; Region: PRK15057 62977000220 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 62977000221 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 62977000222 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 62977000223 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 62977000224 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 62977000225 active site 62977000226 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 62977000227 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_d; cd04196 62977000228 Probable Catalytic site; other site 62977000229 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 62977000230 dTDP-glucose 4,6 dehydratase; Provisional; Region: PRK10084 62977000231 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 62977000232 NAD binding site [chemical binding]; other site 62977000233 substrate binding site [chemical binding]; other site 62977000234 homodimer interface [polypeptide binding]; other site 62977000235 active site 62977000236 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 62977000237 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 62977000238 NADP binding site [chemical binding]; other site 62977000239 active site 62977000240 putative substrate binding site [chemical binding]; other site 62977000241 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 62977000242 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 62977000243 substrate binding site; other site 62977000244 tetramer interface; other site 62977000245 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908 62977000246 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 62977000247 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 62977000248 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 62977000249 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 62977000250 Probable Catalytic site; other site 62977000251 metal-binding site 62977000252 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 62977000253 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 62977000254 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 62977000255 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 62977000256 Probable Catalytic site; other site 62977000257 metal-binding site 62977000258 mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479 62977000259 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 62977000260 Substrate binding site; other site 62977000261 Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050 62977000262 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 62977000263 Vi polysaccharide biosynthesis protein TviB; Provisional; Region: PRK15182 62977000264 NAD(P) binding pocket [chemical binding]; other site 62977000265 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 62977000266 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 62977000267 Vi polysaccharide biosynthesis protein TviC; Provisional; Region: PRK15181 62977000268 UDP-N-acetylglucosamine 4-epimerase, extended (e) SDRs; Region: UDP_AE_SDR_e; cd05256 62977000269 NAD binding site [chemical binding]; other site 62977000270 substrate binding site [chemical binding]; other site 62977000271 homodimer interface [polypeptide binding]; other site 62977000272 active site 62977000273 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 62977000274 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 62977000275 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 62977000276 putative ADP-binding pocket [chemical binding]; other site 62977000277 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 62977000278 This family is most closely related to the GT1 family of glycosyltransferases. WbnK in Shigella dysenteriae has been shown to be involved in the type 7 O-antigen biosynthesis; Region: GT1_WbnK_like; cd03807 62977000279 putative ADP-binding pocket [chemical binding]; other site 62977000280 This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808 62977000281 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 62977000282 putative ADP-binding pocket [chemical binding]; other site 62977000283 Bacterial sugar transferase; Region: Bac_transf; pfam02397 62977000284 Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360 62977000285 sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570 62977000286 putative trimer interface [polypeptide binding]; other site 62977000287 putative CoA binding site [chemical binding]; other site 62977000288 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 62977000289 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 62977000290 inhibitor-cofactor binding pocket; inhibition site 62977000291 pyridoxal 5'-phosphate binding site [chemical binding]; other site 62977000292 catalytic residue [active] 62977000293 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 62977000294 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 62977000295 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 62977000296 NAD(P) binding site [chemical binding]; other site 62977000297 homodimer interface [polypeptide binding]; other site 62977000298 substrate binding site [chemical binding]; other site 62977000299 active site 62977000300 putative UDP-glucose lipid carrier transferase; Provisional; Region: PRK10124 62977000301 Sugar transferases involved in lipopolysaccharide synthesis [Cell envelope biogenesis, outer membrane]; Region: WcaJ; COG2148 62977000302 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 62977000303 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 62977000304 active site 62977000305 tetramer interface; other site 62977000306 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 62977000307 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 62977000308 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 62977000309 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 62977000310 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 62977000311 active site 62977000312 dimer interface [polypeptide binding]; other site 62977000313 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 62977000314 dimer interface [polypeptide binding]; other site 62977000315 active site 62977000316 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 62977000317 UDP-glucose 4-epimerase; Region: PLN02240 62977000318 NAD binding site [chemical binding]; other site 62977000319 homodimer interface [polypeptide binding]; other site 62977000320 active site 62977000321 substrate binding site [chemical binding]; other site 62977000322 O-antigen ligase like membrane protein; Region: O-antigen_lig; pfam13425 62977000323 Domain of unknown function (DUF3366); Region: DUF3366; pfam11846 62977000324 phosphomannomutase CpsG; Provisional; Region: PRK15414 62977000325 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 62977000326 active site 62977000327 substrate binding site [chemical binding]; other site 62977000328 metal binding site [ion binding]; metal-binding site 62977000329 Transcriptional regulator [Transcription]; Region: LysR; COG0583 62977000330 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 62977000331 The C-terminal substrate binding domain of LysR-type transcriptional regulators that are involved in the catabolism of dinitrotoluene, naphthalene and gamma-hexachlorohexane; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_NahR_LinR_like; cd08459 62977000332 substrate binding pocket [chemical binding]; other site 62977000333 dimerization interface [polypeptide binding]; other site 62977000334 L-lactate permease; Provisional; Region: PRK10420 62977000335 glycolate transporter; Provisional; Region: PRK09695 62977000336 DNA-binding transcriptional repressor LldR; Provisional; Region: PRK10421 62977000337 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 62977000338 DNA-binding site [nucleotide binding]; DNA binding site 62977000339 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 62977000340 L-lactate dehydrogenase; Provisional; Region: lldD; PRK11197 62977000341 Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809 62977000342 active site 62977000343 substrate binding site [chemical binding]; other site 62977000344 FMN binding site [chemical binding]; other site 62977000345 putative catalytic residues [active] 62977000346 D-lactate dehydrogenase; Provisional; Region: PRK11183 62977000347 FAD binding domain; Region: FAD_binding_4; pfam01565 62977000348 D-lactate dehydrogenase, membrane binding; Region: Lact-deh-memb; pfam09330 62977000349 Capsule assembly protein Wzi; Region: Caps_assemb_Wzi; pfam14052 62977000350 Sugar efflux transporter for intercellular exchange; Region: MtN3_slv; pfam03083 62977000351 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 62977000352 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 62977000353 pyridoxal 5'-phosphate binding site [chemical binding]; other site 62977000354 homodimer interface [polypeptide binding]; other site 62977000355 catalytic residue [active] 62977000356 leucine-responsive transcriptional regulator; Provisional; Region: PRK11169 62977000357 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 62977000358 dimerization interface [polypeptide binding]; other site 62977000359 putative DNA binding site [nucleotide binding]; other site 62977000360 putative Zn2+ binding site [ion binding]; other site 62977000361 AsnC family; Region: AsnC_trans_reg; pfam01037 62977000362 D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711 62977000363 hydroxyglutarate oxidase; Provisional; Region: PRK11728 62977000364 alanine racemase; Reviewed; Region: dadX; PRK03646 62977000365 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827 62977000366 active site 62977000367 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 62977000368 substrate binding site [chemical binding]; other site 62977000369 catalytic residues [active] 62977000370 dimer interface [polypeptide binding]; other site 62977000371 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150 62977000372 homotrimer interaction site [polypeptide binding]; other site 62977000373 putative active site [active] 62977000374 D-alanine/D-serine/glycine permease; Provisional; Region: PRK11049 62977000375 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 62977000376 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 62977000377 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 62977000378 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 62977000379 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 62977000380 PapC N-terminal domain; Region: PapC_N; pfam13954 62977000381 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 62977000382 PapC C-terminal domain; Region: PapC_C; pfam13953 62977000383 Fimbrial protein; Region: Fimbrial; cl01416 62977000384 fimbrial assembly chaperone StbE; Provisional; Region: PRK15246 62977000385 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 62977000386 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 62977000387 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 62977000388 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 62977000389 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 62977000390 EamA-like transporter family; Region: EamA; pfam00892 62977000391 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 62977000392 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 62977000393 galactarate dehydratase; Region: galactar-dH20; TIGR03248 62977000394 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 62977000395 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 62977000396 D-galactonate transporter; Region: 2A0114; TIGR00893 62977000397 putative substrate translocation pore; other site 62977000398 glucarate dehydratase; Region: glucar-dehydr; TIGR03247 62977000399 D-Glucarate dehydratase (GlucD) catalyzes the dehydration of both D-glucarate and L-idarate to form 5-keto-4-deoxy-D-glucarate (5-KDG) , the initial reaction of the catabolic pathway for (D)-glucarate. GlucD belongs to the enolase superfamily of enzymes; Region: D-glucarate_dehydratase; cd03323 62977000400 active site 62977000401 tetramer interface [polypeptide binding]; other site 62977000402 5-dehydro-4-deoxyglucarate dehydratase, also called 5-keto-4-deoxy-glucarate dehydratase (KDGDH); Region: KDGDH; cd00951 62977000403 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 62977000404 putative active site [active] 62977000405 catalytic residue [active] 62977000406 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 62977000407 Alpha-Ketoglutaric Semialdehyde Dehydrogenase; Region: ALDH_KGSADH; cd07129 62977000408 dimer interface [polypeptide binding]; other site 62977000409 NADP binding site [chemical binding]; other site 62977000410 catalytic residues [active] 62977000411 Transcriptional regulators [Transcription]; Region: FadR; COG2186 62977000412 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 62977000413 DNA-binding site [nucleotide binding]; DNA binding site 62977000414 FCD domain; Region: FCD; pfam07729 62977000415 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_4; cd12162 62977000416 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 62977000417 putative ligand binding site [chemical binding]; other site 62977000418 putative NAD binding site [chemical binding]; other site 62977000419 catalytic site [active] 62977000420 Integrase core domain; Region: rve; pfam00665 62977000421 Transcriptional regulators [Transcription]; Region: PurR; COG1609 62977000422 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 62977000423 DNA binding site [nucleotide binding] 62977000424 domain linker motif; other site 62977000425 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_8; cd06287 62977000426 putative dimerization interface [polypeptide binding]; other site 62977000427 putative ligand binding site [chemical binding]; other site 62977000428 xanthine permease; Region: pbuX; TIGR03173 62977000429 Cytosine deaminase and related metal-dependent hydrolases [Nucleotide transport and metabolism / General function prediction only]; Region: SsnA; COG0402 62977000430 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 62977000431 active site 62977000432 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 62977000433 Stress-induced morphogen (activity unknown) [Signal transduction mechanisms]; Region: BolA; COG0271 62977000434 Invasion gene expression up-regulator, SirB; Region: SirB; cl01184 62977000435 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 62977000436 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 62977000437 P-loop; other site 62977000438 Magnesium ion binding site [ion binding]; other site 62977000439 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 62977000440 Magnesium ion binding site [ion binding]; other site 62977000441 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 62977000442 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 62977000443 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 62977000444 Predicted membrane protein [Function unknown]; Region: COG2259 62977000445 Bacterial OB fold (BOF) protein; Region: BOF; cl01196 62977000446 GMP synthase; Reviewed; Region: guaA; PRK00074 62977000447 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 62977000448 AMP/PPi binding site [chemical binding]; other site 62977000449 candidate oxyanion hole; other site 62977000450 catalytic triad [active] 62977000451 potential glutamine specificity residues [chemical binding]; other site 62977000452 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 62977000453 ATP Binding subdomain [chemical binding]; other site 62977000454 Ligand Binding sites [chemical binding]; other site 62977000455 Dimerization subdomain; other site 62977000456 AAA domain; Region: AAA_13; pfam13166 62977000457 Predicted transcriptional regulators [Transcription]; Region: COG1695 62977000458 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 62977000459 Domain of Unknown Function with PDB structure (DUF3861); Region: DUF3861; pfam12977 62977000460 Protein of unknown function (DUF2798); Region: DUF2798; pfam11391 62977000461 Pirin; Region: Pirin; pfam02678 62977000462 Pirin-related protein [General function prediction only]; Region: COG1741 62977000463 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 62977000464 OsmC-like protein; Region: OsmC; pfam02566 62977000465 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 62977000466 GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046 62977000467 putative C-terminal domain interface [polypeptide binding]; other site 62977000468 putative GSH binding site (G-site) [chemical binding]; other site 62977000469 putative dimer interface [polypeptide binding]; other site 62977000470 C-terminal, alpha helical domain of GTT1-like Glutathione S-transferases; Region: GST_C_GTT1_like; cd03189 62977000471 putative N-terminal domain interface [polypeptide binding]; other site 62977000472 putative dimer interface [polypeptide binding]; other site 62977000473 putative substrate binding pocket (H-site) [chemical binding]; other site 62977000474 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 62977000475 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 62977000476 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 62977000477 EamA-like transporter family; Region: EamA; pfam00892 62977000478 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 62977000479 EamA-like transporter family; Region: EamA; pfam00892 62977000480 Putative ParB-like nuclease; Region: ParBc_2; pfam08857 62977000481 Sporulation related domain; Region: SPOR; pfam05036 62977000482 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 62977000483 Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018 62977000484 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 62977000485 active site 62977000486 HIGH motif; other site 62977000487 nucleotide binding site [chemical binding]; other site 62977000488 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 62977000489 KMSK motif region; other site 62977000490 tRNA binding surface [nucleotide binding]; other site 62977000491 DALR anticodon binding domain; Region: DALR_1; smart00836 62977000492 anticodon binding site; other site 62977000493 malate dehydrogenase; Provisional; Region: PRK13529 62977000494 Malic enzyme, N-terminal domain; Region: malic; pfam00390 62977000495 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 62977000496 NAD(P) binding site [chemical binding]; other site 62977000497 Uncharacterized protein conserved in bacteria [Function unknown]; Region: VgrG; COG3501 62977000498 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 62977000499 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 62977000500 Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296 62977000501 Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; pfam10106 62977000502 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 62977000503 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 62977000504 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 62977000505 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 62977000506 Dyp-type peroxidase family; Region: Dyp_perox; cl01067 62977000507 LysE type translocator; Region: LysE; cl00565 62977000508 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 62977000509 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 62977000510 putative PBP binding regions; other site 62977000511 ABC-ATPase subunit interface; other site 62977000512 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 62977000513 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 62977000514 Walker A/P-loop; other site 62977000515 ATP binding site [chemical binding]; other site 62977000516 Q-loop/lid; other site 62977000517 ABC transporter signature motif; other site 62977000518 Walker B; other site 62977000519 D-loop; other site 62977000520 H-loop/switch region; other site 62977000521 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 62977000522 metal binding site 2 [ion binding]; metal-binding site 62977000523 putative DNA binding helix; other site 62977000524 metal binding site 1 [ion binding]; metal-binding site 62977000525 dimer interface [polypeptide binding]; other site 62977000526 structural Zn2+ binding site [ion binding]; other site 62977000527 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 62977000528 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 62977000529 intersubunit interface [polypeptide binding]; other site 62977000530 ATP synthase I chain; Region: ATP_synt_I; cl09170 62977000531 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 62977000532 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 62977000533 F0F1 ATP synthase subunit C; Validated; Region: PRK06876 62977000534 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 62977000535 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 62977000536 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 62977000537 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 62977000538 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 62977000539 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 62977000540 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 62977000541 Walker A motif; other site 62977000542 ATP binding site [chemical binding]; other site 62977000543 Walker B motif; other site 62977000544 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 62977000545 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 62977000546 core domain interface [polypeptide binding]; other site 62977000547 delta subunit interface [polypeptide binding]; other site 62977000548 epsilon subunit interface [polypeptide binding]; other site 62977000549 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 62977000550 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 62977000551 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 62977000552 alpha subunit interaction interface [polypeptide binding]; other site 62977000553 Walker A motif; other site 62977000554 ATP binding site [chemical binding]; other site 62977000555 Walker B motif; other site 62977000556 inhibitor binding site; inhibition site 62977000557 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 62977000558 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 62977000559 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 62977000560 gamma subunit interface [polypeptide binding]; other site 62977000561 epsilon subunit interface [polypeptide binding]; other site 62977000562 LBP interface [polypeptide binding]; other site 62977000563 Protein of unknown function (DUF2846); Region: DUF2846; pfam11008 62977000564 D-hexose-6-phosphate epimerase-like; Region: D-hex-6-P-epi_like; cd09020 62977000565 active site 62977000566 phosphate binding residues; other site 62977000567 catalytic residues [active] 62977000568 polar chromosome segregation protein; Reviewed; Region: racA; PRK13182 62977000569 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 62977000570 catalytic residues [active] 62977000571 dimer interface [polypeptide binding]; other site 62977000572 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 62977000573 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 62977000574 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 62977000575 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 62977000576 putative substrate translocation pore; other site 62977000577 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 62977000578 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 62977000579 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 62977000580 EamA-like transporter family; Region: EamA; pfam00892 62977000581 EamA-like transporter family; Region: EamA; pfam00892 62977000582 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 62977000583 Periplasmic binding domain of the basic membrane lipoprotein Med in Bacillus and its close homologs from other bacteria and Archaea; Region: PBP1_BmpA_Med_like; cd06353 62977000584 putative ligand binding site [chemical binding]; other site 62977000585 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 62977000586 iron-sulfur cluster [ion binding]; other site 62977000587 [2Fe-2S] cluster binding site [ion binding]; other site 62977000588 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 62977000589 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 62977000590 hydrophobic ligand binding site; other site 62977000591 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 62977000592 N-terminal domain interface [polypeptide binding]; other site 62977000593 Transcriptional regulator [Transcription]; Region: LysR; COG0583 62977000594 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 62977000595 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_4; cd08463 62977000596 putative substrate binding pocket [chemical binding]; other site 62977000597 putative dimerization interface [polypeptide binding]; other site 62977000598 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 62977000599 nucleoside/Zn binding site; other site 62977000600 dimer interface [polypeptide binding]; other site 62977000601 catalytic motif [active] 62977000602 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 62977000603 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 62977000604 Walker A/P-loop; other site 62977000605 ATP binding site [chemical binding]; other site 62977000606 Q-loop/lid; other site 62977000607 ABC transporter signature motif; other site 62977000608 Walker B; other site 62977000609 D-loop; other site 62977000610 H-loop/switch region; other site 62977000611 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 62977000612 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 62977000613 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 62977000614 TM-ABC transporter signature motif; other site 62977000615 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 62977000616 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 62977000617 TM-ABC transporter signature motif; other site 62977000618 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 62977000619 DNA protecting protein DprA; Region: dprA; TIGR00732 62977000620 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 62977000621 Uncharacterized protein containing LysM domain [Function unknown]; Region: XkdP; COG1652 62977000622 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 62977000623 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 62977000624 active site 62977000625 catalytic residues [active] 62977000626 metal binding site [ion binding]; metal-binding site 62977000627 TonB-dependent copper receptor; Region: TonB-copper; TIGR01778 62977000628 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 62977000629 N-terminal plug; other site 62977000630 ligand-binding site [chemical binding]; other site 62977000631 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; pfam09995 62977000632 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 62977000633 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 62977000634 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 62977000635 hypothetical protein; Provisional; Region: PRK01254 62977000636 Radical SAM N-terminal; Region: Radical_SAM_N; pfam08497 62977000637 Radical SAM N-terminal; Region: Radical_SAM_N; pfam08497 62977000638 Domain of unknown function (DUF3362); Region: DUF3362; pfam11842 62977000639 Protein of unknown function (DUF2726); Region: DUF2726; pfam10881 62977000640 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150 62977000641 homotrimer interaction site [polypeptide binding]; other site 62977000642 putative active site [active] 62977000643 shikimate transporter; Provisional; Region: PRK09952 62977000644 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 62977000645 putative substrate translocation pore; other site 62977000646 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 62977000647 active site 62977000648 DNA polymerase IV; Validated; Region: PRK02406 62977000649 DNA binding site [nucleotide binding] 62977000650 Uncharacterized bacterial muramidase containing a glycosyl hydrolase family 25 (GH25) catalytic domain. Endo-N-acetylmuramidases are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis...; Region: GH25_muramidase_1; cd06413 62977000651 active site 62977000652 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 62977000653 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 62977000654 putative transporter; Provisional; Region: PRK10504 62977000655 putative substrate translocation pore; other site 62977000656 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 62977000657 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 62977000658 Predicted transcriptional regulator, contains C-terminal CBS domains [Transcription]; Region: COG2524 62977000659 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 62977000660 Transporter associated domain; Region: CorC_HlyC; smart01091 62977000661 hypothetical protein; Provisional; Region: PRK01752 62977000662 SEC-C motif; Region: SEC-C; pfam02810 62977000663 hypothetical protein; Provisional; Region: PRK10578 62977000664 UPF0126 domain; Region: UPF0126; pfam03458 62977000665 UPF0126 domain; Region: UPF0126; pfam03458 62977000666 benzoate transport; Region: 2A0115; TIGR00895 62977000667 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 62977000668 putative substrate translocation pore; other site 62977000669 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 62977000670 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 62977000671 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 62977000672 CAP-like domain; other site 62977000673 active site 62977000674 primary dimer interface [polypeptide binding]; other site 62977000675 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 62977000676 Long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07059 62977000677 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 62977000678 acyl-activating enzyme (AAE) consensus motif; other site 62977000679 putative AMP binding site [chemical binding]; other site 62977000680 putative active site [active] 62977000681 putative CoA binding site [chemical binding]; other site 62977000682 MAPEG family; Region: MAPEG; cl09190 62977000683 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 62977000684 dimer interface [polypeptide binding]; other site 62977000685 substrate binding site [chemical binding]; other site 62977000686 metal binding sites [ion binding]; metal-binding site 62977000687 outer membrane porin, OprD family; Region: OprD; pfam03573 62977000688 Bacterial protein of unknown function (Gcw_chp); Region: Gcw_chp; cl09901 62977000689 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 62977000690 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 62977000691 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 62977000692 Walker A motif; other site 62977000693 ATP binding site [chemical binding]; other site 62977000694 Walker B motif; other site 62977000695 arginine finger; other site 62977000696 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 62977000697 Membrane fusogenic activity; Region: BMFP; pfam04380 62977000698 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 62977000699 Nitrogen regulatory protein P-II; Region: P-II; smart00938 62977000700 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 62977000701 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 62977000702 ATP cone domain; Region: ATP-cone; pfam03477 62977000703 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 62977000704 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 62977000705 catalytic motif [active] 62977000706 Zn binding site [ion binding]; other site 62977000707 RibD C-terminal domain; Region: RibD_C; cl17279 62977000708 Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG3392 62977000709 D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; cl17344 62977000710 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 62977000711 Lumazine binding domain; Region: Lum_binding; pfam00677 62977000712 Lumazine binding domain; Region: Lum_binding; pfam00677 62977000713 DNA polymerase III chi subunit, HolC; Region: DNA_pol3_chi; pfam04364 62977000714 multifunctional aminopeptidase A; Provisional; Region: PRK00913 62977000715 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 62977000716 interface (dimer of trimers) [polypeptide binding]; other site 62977000717 Substrate-binding/catalytic site; other site 62977000718 Zn-binding sites [ion binding]; other site 62977000719 Predicted permeases [General function prediction only]; Region: COG0795; cl12074 62977000720 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 62977000721 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 62977000722 Predicted permeases [General function prediction only]; Region: COG0795; cl12074 62977000723 phosphoglyceromutase; Provisional; Region: PRK05434 62977000724 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 62977000725 Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793 62977000726 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 62977000727 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cd00136 62977000728 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 62977000729 Catalytic dyad [active] 62977000730 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 62977000731 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 62977000732 active site 62977000733 phosphorylation site [posttranslational modification] 62977000734 intermolecular recognition site; other site 62977000735 dimerization interface [polypeptide binding]; other site 62977000736 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 62977000737 Walker A motif; other site 62977000738 ATP binding site [chemical binding]; other site 62977000739 Walker B motif; other site 62977000740 arginine finger; other site 62977000741 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 62977000742 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 62977000743 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 62977000744 dimer interface [polypeptide binding]; other site 62977000745 phosphorylation site [posttranslational modification] 62977000746 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 62977000747 ATP binding site [chemical binding]; other site 62977000748 Mg2+ binding site [ion binding]; other site 62977000749 G-X-G motif; other site 62977000750 response regulator; Provisional; Region: PRK09483 62977000751 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 62977000752 active site 62977000753 phosphorylation site [posttranslational modification] 62977000754 intermolecular recognition site; other site 62977000755 dimerization interface [polypeptide binding]; other site 62977000756 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 62977000757 DNA binding residues [nucleotide binding] 62977000758 dimerization interface [polypeptide binding]; other site 62977000759 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 62977000760 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 62977000761 threonine synthase; Reviewed; Region: PRK06721 62977000762 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 62977000763 homodimer interface [polypeptide binding]; other site 62977000764 pyridoxal 5'-phosphate binding site [chemical binding]; other site 62977000765 catalytic residue [active] 62977000766 homoserine dehydrogenase; Provisional; Region: PRK06349 62977000767 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 62977000768 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 62977000769 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 62977000770 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020 62977000771 dimerization domain [polypeptide binding]; other site 62977000772 dimer interface [polypeptide binding]; other site 62977000773 catalytic residues [active] 62977000774 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 62977000775 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 62977000776 active site 62977000777 DNA binding site [nucleotide binding] 62977000778 Int/Topo IB signature motif; other site 62977000779 Fe2+ transport system protein A [Inorganic ion transport and metabolism]; Region: FeoA; COG1918 62977000780 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 62977000781 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 62977000782 G1 box; other site 62977000783 GTP/Mg2+ binding site [chemical binding]; other site 62977000784 Switch I region; other site 62977000785 G2 box; other site 62977000786 G3 box; other site 62977000787 Switch II region; other site 62977000788 G4 box; other site 62977000789 G5 box; other site 62977000790 Nucleoside recognition; Region: Gate; pfam07670 62977000791 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 62977000792 Nucleoside recognition; Region: Gate; pfam07670 62977000793 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK03803 62977000794 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 62977000795 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 62977000796 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 62977000797 cell division protein FtsW; Region: ftsW; TIGR02614 62977000798 glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710 62977000799 active site 62977000800 nucleotide binding site [chemical binding]; other site 62977000801 HIGH motif; other site 62977000802 KMSKS motif; other site 62977000803 RNA polymerase-binding protein DksA; Region: dksA; TIGR02420 62977000804 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 62977000805 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 62977000806 active site 62977000807 metal binding site [ion binding]; metal-binding site 62977000808 hexamer interface [polypeptide binding]; other site 62977000809 ADP-ribose pyrophosphatase NudF; Provisional; Region: nudF; PRK10729 62977000810 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 62977000811 ADP-ribose binding site [chemical binding]; other site 62977000812 dimer interface [polypeptide binding]; other site 62977000813 active site 62977000814 nudix motif; other site 62977000815 metal binding site [ion binding]; metal-binding site 62977000816 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 62977000817 ThiC-associated domain; Region: ThiC-associated; pfam13667 62977000818 Thiamine biosynthesis protein ThiC [Coenzyme metabolism]; Region: ThiC; COG0422 62977000819 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 62977000820 transcriptional regulator PhoU; Provisional; Region: PRK11115 62977000821 PhoU domain; Region: PhoU; pfam01895 62977000822 PhoU domain; Region: PhoU; pfam01895 62977000823 oxidative damage protection protein; Provisional; Region: PRK05408 62977000824 argininosuccinate lyase; Provisional; Region: PRK00855 62977000825 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 62977000826 active sites [active] 62977000827 tetramer interface [polypeptide binding]; other site 62977000828 Histidine kinase; Region: His_kinase; pfam06580 62977000829 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 62977000830 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 62977000831 active site 62977000832 phosphorylation site [posttranslational modification] 62977000833 intermolecular recognition site; other site 62977000834 dimerization interface [polypeptide binding]; other site 62977000835 LytTr DNA-binding domain; Region: LytTR; smart00850 62977000836 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 62977000837 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 62977000838 domain interfaces; other site 62977000839 active site 62977000840 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 62977000841 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 62977000842 active site 62977000843 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 62977000844 active site 62977000845 H-NS histone family; Region: Histone_HNS; pfam00816 62977000846 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 62977000847 Type II secretion system (T2SS), protein N; Region: T2SN; pfam01203 62977000848 Type II secretory pathway, component PulC [Intracellular trafficking and secretion]; Region: PulC; COG3031 62977000849 Type IV pilus biogenesis; Region: Pilus_PilP; pfam11356 62977000850 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 62977000851 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 62977000852 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 62977000853 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 62977000854 pilus (MSHA type) biogenesis protein MshL; Region: pilus_MshL; TIGR02519 62977000855 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 62977000856 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 62977000857 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 62977000858 phosphopeptide binding site; other site 62977000859 phosphoglycolate phosphatase; Provisional; Region: PRK13222 62977000860 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 62977000861 motif II; other site 62977000862 anthranilate synthase component I; Provisional; Region: PRK13565 62977000863 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 62977000864 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 62977000865 elongation factor Tu; Reviewed; Region: PRK00049 62977000866 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 62977000867 G1 box; other site 62977000868 GEF interaction site [polypeptide binding]; other site 62977000869 GTP/Mg2+ binding site [chemical binding]; other site 62977000870 Switch I region; other site 62977000871 G2 box; other site 62977000872 G3 box; other site 62977000873 Switch II region; other site 62977000874 G4 box; other site 62977000875 G5 box; other site 62977000876 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 62977000877 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 62977000878 Antibiotic Binding Site [chemical binding]; other site 62977000879 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK05740 62977000880 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 62977000881 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 62977000882 putative homodimer interface [polypeptide binding]; other site 62977000883 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 62977000884 heterodimer interface [polypeptide binding]; other site 62977000885 homodimer interface [polypeptide binding]; other site 62977000886 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 62977000887 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 62977000888 23S rRNA interface [nucleotide binding]; other site 62977000889 L7/L12 interface [polypeptide binding]; other site 62977000890 putative thiostrepton binding site; other site 62977000891 L25 interface [polypeptide binding]; other site 62977000892 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 62977000893 mRNA/rRNA interface [nucleotide binding]; other site 62977000894 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 62977000895 23S rRNA interface [nucleotide binding]; other site 62977000896 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 62977000897 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 62977000898 core dimer interface [polypeptide binding]; other site 62977000899 peripheral dimer interface [polypeptide binding]; other site 62977000900 L10 interface [polypeptide binding]; other site 62977000901 L11 interface [polypeptide binding]; other site 62977000902 putative EF-Tu interaction site [polypeptide binding]; other site 62977000903 putative EF-G interaction site [polypeptide binding]; other site 62977000904 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 62977000905 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 62977000906 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 62977000907 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 62977000908 RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562 62977000909 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 62977000910 RPB1 interaction site [polypeptide binding]; other site 62977000911 RPB11 interaction site [polypeptide binding]; other site 62977000912 RPB10 interaction site [polypeptide binding]; other site 62977000913 RPB3 interaction site [polypeptide binding]; other site 62977000914 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 62977000915 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 62977000916 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 62977000917 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 62977000918 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 62977000919 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 62977000920 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 62977000921 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 62977000922 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 62977000923 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 62977000924 DNA binding site [nucleotide binding] 62977000925 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 62977000926 Putative thioesterase (yiiD_Cterm); Region: YiiD_Cterm; cl17557 62977000927 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 62977000928 active site 2 [active] 62977000929 active site 1 [active] 62977000930 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 62977000931 Predicted permease [General function prediction only]; Region: COG2056 62977000932 Na+-H+ antiporter family; Region: Na_H_antiport_2; pfam13726 62977000933 OmpW family; Region: OmpW; cl17427 62977000934 Protein of unknown function (DUF1311); Region: DUF1311; pfam07007 62977000935 heat shock protein 90; Provisional; Region: PRK05218 62977000936 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 62977000937 ATP binding site [chemical binding]; other site 62977000938 Mg2+ binding site [ion binding]; other site 62977000939 G-X-G motif; other site 62977000940 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 62977000941 aspartate racemase; Region: asp_race; TIGR00035 62977000942 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 62977000943 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 62977000944 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 62977000945 Transposase; Region: HTH_Tnp_1; pfam01527 62977000946 putative transposase OrfB; Reviewed; Region: PHA02517 62977000947 HTH-like domain; Region: HTH_21; pfam13276 62977000948 Integrase core domain; Region: rve; pfam00665 62977000949 Integrase core domain; Region: rve_2; pfam13333 62977000950 cell density-dependent motility repressor; Provisional; Region: PRK10082 62977000951 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 62977000952 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 62977000953 dimerization interface [polypeptide binding]; other site 62977000954 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 62977000955 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 62977000956 catalytic residues [active] 62977000957 aconitate hydratase; Validated; Region: PRK09277 62977000958 3-ketoacyl-CoA thiolase; Reviewed; Region: fadA; PRK08947 62977000959 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 62977000960 dimer interface [polypeptide binding]; other site 62977000961 active site 62977000962 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadB; PRK11730 62977000963 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 62977000964 substrate binding site [chemical binding]; other site 62977000965 oxyanion hole (OAH) forming residues; other site 62977000966 trimer interface [polypeptide binding]; other site 62977000967 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 62977000968 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 62977000969 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 62977000970 Aspartyl/asparaginyl beta-hydroxylase and related dioxygenases [Posttranslational modification, protein turnover, chaperones]; Region: COG3555 62977000971 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 62977000972 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 62977000973 GIY-YIG motif/motif A; other site 62977000974 active site 62977000975 catalytic site [active] 62977000976 putative DNA binding site [nucleotide binding]; other site 62977000977 metal binding site [ion binding]; metal-binding site 62977000978 UvrB/uvrC motif; Region: UVR; pfam02151 62977000979 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 62977000980 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 62977000981 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 62977000982 active site 62977000983 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II; cd00556 62977000984 active site 62977000985 dimer interface [polypeptide binding]; other site 62977000986 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 62977000987 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 62977000988 Helix-turn-helix domain; Region: HTH_18; pfam12833 62977000989 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 62977000990 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 62977000991 DNA binding site [nucleotide binding] 62977000992 active site 62977000993 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_2; pfam13532 62977000994 Transcriptional regulator [Transcription]; Region: IclR; COG1414 62977000995 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 62977000996 Bacterial transcriptional regulator; Region: IclR; pfam01614 62977000997 Fusaric acid resistance protein family; Region: FUSC; pfam04632 62977000998 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 62977000999 Protein of unknown function (DUF1656); Region: DUF1656; pfam07869 62977001000 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 62977001001 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 62977001002 HlyD family secretion protein; Region: HlyD_3; pfam13437 62977001003 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 62977001004 Uncharacterized ACR, COG1678; Region: DUF179; pfam02622 62977001005 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 62977001006 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 62977001007 Walker A/P-loop; other site 62977001008 ATP binding site [chemical binding]; other site 62977001009 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 62977001010 ABC transporter signature motif; other site 62977001011 Walker B; other site 62977001012 D-loop; other site 62977001013 H-loop/switch region; other site 62977001014 Tetratricopeptide repeat; Region: TPR_16; pfam13432 62977001015 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 62977001016 TPR motif; other site 62977001017 Protein of unknown function (DUF1255); Region: DUF1255; pfam06865 62977001018 23S rRNA (guanosine-2'-O-)-methyltransferase; Provisional; Region: PRK11181 62977001019 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 62977001020 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 62977001021 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 62977001022 EamA-like transporter family; Region: EamA; pfam00892 62977001023 EamA-like transporter family; Region: EamA; pfam00892 62977001024 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 62977001025 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 62977001026 CoA-binding site [chemical binding]; other site 62977001027 ATP-binding [chemical binding]; other site 62977001028 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 62977001029 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 62977001030 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 62977001031 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 62977001032 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 62977001033 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 62977001034 type IV-A pilus assembly ATPase PilB; Region: type_IV_pilB; TIGR02538 62977001035 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 62977001036 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 62977001037 Walker A motif; other site 62977001038 ATP binding site [chemical binding]; other site 62977001039 Walker B motif; other site 62977001040 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 62977001041 triosephosphate isomerase; Provisional; Region: PRK14567 62977001042 substrate binding site [chemical binding]; other site 62977001043 dimer interface [polypeptide binding]; other site 62977001044 catalytic triad [active] 62977001045 Preprotein translocase SecG subunit; Region: SecG; pfam03840 62977001046 ribosome maturation protein RimP; Reviewed; Region: PRK00092 62977001047 Sm and related proteins; Region: Sm_like; cl00259 62977001048 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 62977001049 putative oligomer interface [polypeptide binding]; other site 62977001050 putative RNA binding site [nucleotide binding]; other site 62977001051 transcription elongation factor NusA; Validated; Region: nusA; PRK09202 62977001052 NusA N-terminal domain; Region: NusA_N; pfam08529 62977001053 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 62977001054 RNA binding site [nucleotide binding]; other site 62977001055 homodimer interface [polypeptide binding]; other site 62977001056 NusA-like KH domain; Region: KH_5; pfam13184 62977001057 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 62977001058 G-X-X-G motif; other site 62977001059 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 62977001060 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 62977001061 translation initiation factor IF-2; Region: IF-2; TIGR00487 62977001062 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 62977001063 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 62977001064 G1 box; other site 62977001065 putative GEF interaction site [polypeptide binding]; other site 62977001066 GTP/Mg2+ binding site [chemical binding]; other site 62977001067 Switch I region; other site 62977001068 G2 box; other site 62977001069 G3 box; other site 62977001070 Switch II region; other site 62977001071 G4 box; other site 62977001072 G5 box; other site 62977001073 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 62977001074 Translation-initiation factor 2; Region: IF-2; pfam11987 62977001075 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 62977001076 ribosome-binding factor A; Provisional; Region: PRK13816 62977001077 putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12674 62977001078 putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK06161 62977001079 putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK08965 62977001080 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12666 62977001081 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 62977001082 putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK09094 62977001083 putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12648 62977001084 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 62977001085 Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111 62977001086 putative monovalent cation/H+ antiporter subunit B; Reviewed; Region: PRK12573 62977001087 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 62977001088 AAA domain; Region: AAA_23; pfam13476 62977001089 Walker A/P-loop; other site 62977001090 ATP binding site [chemical binding]; other site 62977001091 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 62977001092 Walker A/P-loop; other site 62977001093 ATP binding site [chemical binding]; other site 62977001094 Family description; Region: UvrD_C_2; pfam13538 62977001095 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 62977001096 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 62977001097 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 62977001098 metal binding site [ion binding]; metal-binding site 62977001099 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 62977001100 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 62977001101 ABC1 family; Region: ABC1; cl17513 62977001102 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 62977001103 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3165 62977001104 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 62977001105 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 62977001106 S-adenosylmethionine binding site [chemical binding]; other site 62977001107 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4627 62977001108 Fimbrial protein; Region: Fimbrial; cl01416 62977001109 putative chaperone protein EcpD; Provisional; Region: PRK09926 62977001110 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 62977001111 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 62977001112 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 62977001113 PapC N-terminal domain; Region: PapC_N; pfam13954 62977001114 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 62977001115 PapC C-terminal domain; Region: PapC_C; pfam13953 62977001116 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 62977001117 Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971 62977001118 polyphosphate:AMP phosphotransferase; Region: poly_P_AMP_trns; TIGR03708 62977001119 Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971 62977001120 citrate-proton symporter; Provisional; Region: PRK15075 62977001121 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 62977001122 putative substrate translocation pore; other site 62977001123 Exodeoxyribonuclease V, gamma subunit; Region: Exonuc_V_gamma; pfam04257 62977001124 exonuclease V subunit gamma; Provisional; Region: recC; PRK11069 62977001125 Part of AAA domain; Region: AAA_19; pfam13245 62977001126 ATP-dependent exoDNAse (exonuclease V) beta subunit (contains helicase and exonuclease domains) [DNA replication, recombination, and repair]; Region: RecB; COG1074 62977001127 Family description; Region: UvrD_C_2; pfam13538 62977001128 AAA domain; Region: AAA_30; pfam13604 62977001129 Family description; Region: UvrD_C_2; pfam13538 62977001130 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 62977001131 Beta-lactamase; Region: Beta-lactamase; pfam00144 62977001132 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 62977001133 16S/18S rRNA binding site [nucleotide binding]; other site 62977001134 S13e-L30e interaction site [polypeptide binding]; other site 62977001135 25S rRNA binding site [nucleotide binding]; other site 62977001136 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 62977001137 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 62977001138 RNase E interface [polypeptide binding]; other site 62977001139 trimer interface [polypeptide binding]; other site 62977001140 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 62977001141 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 62977001142 RNase E interface [polypeptide binding]; other site 62977001143 trimer interface [polypeptide binding]; other site 62977001144 active site 62977001145 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 62977001146 putative nucleic acid binding region [nucleotide binding]; other site 62977001147 G-X-X-G motif; other site 62977001148 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 62977001149 RNA binding site [nucleotide binding]; other site 62977001150 domain interface; other site 62977001151 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 62977001152 Thermotoga maritima CorA-like family; Region: TmCorA-like; cd12822 62977001153 oligomer interface [polypeptide binding]; other site 62977001154 metal binding site [ion binding]; metal-binding site 62977001155 metal binding site [ion binding]; metal-binding site 62977001156 putative Cl binding site [ion binding]; other site 62977001157 aspartate ring; other site 62977001158 basic sphincter; other site 62977001159 hydrophobic gate; other site 62977001160 periplasmic entrance; other site 62977001161 chromosome condensation membrane protein; Provisional; Region: PRK14196 62977001162 MerR HTH family regulatory protein; Region: MerR_2; pfam13591 62977001163 chaperone-modulator protein CbpM; Provisional; Region: PRK10265 62977001164 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 62977001165 chaperone protein DnaJ; Region: DnaJ_bact; TIGR02349 62977001166 HSP70 interaction site [polypeptide binding]; other site 62977001167 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 62977001168 substrate binding site [polypeptide binding]; other site 62977001169 dimer interface [polypeptide binding]; other site 62977001170 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 62977001171 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 62977001172 dimerization interface [polypeptide binding]; other site 62977001173 domain crossover interface; other site 62977001174 redox-dependent activation switch; other site 62977001175 glutathione-regulated potassium-efflux system protein KefC; Provisional; Region: PRK03562 62977001176 transporter, monovalent cation:proton antiporter-2 (CPA2) family; Region: 2a37; TIGR00932 62977001177 TrkA-N domain; Region: TrkA_N; pfam02254 62977001178 primosome assembly protein PriA; Validated; Region: PRK05580 62977001179 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 62977001180 ATP binding site [chemical binding]; other site 62977001181 putative Mg++ binding site [ion binding]; other site 62977001182 FYVE domain; Zinc-binding domain; targets proteins to membrane lipids via interaction with phosphatidylinositol-3-phosphate, PI3P; present in Fab1, YOTB, Vac1, and EEA1; Region: FYVE; cl17764 62977001183 Zn binding sites [ion binding]; other site 62977001184 phosphatidylinositol 3-phosphate binding site [chemical binding]; other site 62977001185 helicase superfamily c-terminal domain; Region: HELICc; smart00490 62977001186 ATP-binding site [chemical binding]; other site 62977001187 type II secretion system protein F; Region: GspF; TIGR02120 62977001188 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 62977001189 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 62977001190 type II secretion system protein G; Region: typeII_sec_gspG; TIGR01710 62977001191 Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334 62977001192 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 62977001193 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 62977001194 putative active site [active] 62977001195 catalytic triad [active] 62977001196 putative dimer interface [polypeptide binding]; other site 62977001197 FOG: CBS domain [General function prediction only]; Region: COG0517 62977001198 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 62977001199 Transporter associated domain; Region: CorC_HlyC; smart01091 62977001200 SirA (also known as UvrY, and YhhP) belongs to a family of two-component response regulators that controls secondary metabolism and virulence. The other member of this two-component system is a sensor kinase called BarA which phosphorylates SirA. A...; Region: SirA; cd03423 62977001201 CPxP motif; other site 62977001202 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 62977001203 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 62977001204 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 62977001205 shikimate binding site; other site 62977001206 NAD(P) binding site [chemical binding]; other site 62977001207 Domain of unknown function (DUF329); Region: DUF329; pfam03884 62977001208 Putative methyltransferase; Region: Methyltransf_4; cl17290 62977001209 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 62977001210 uncharacterized flavoprotein, PP_4765 family; Region: flavo_PP4765; TIGR03862 62977001211 Uncharacterized conserved protein [Function unknown]; Region: COG3791 62977001212 HopJ type III effector protein; Region: HopJ; pfam08888 62977001213 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 62977001214 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 62977001215 ABC1 family; Region: ABC1; cl17513 62977001216 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 62977001217 Dibenzothiophene (DBT) desulfurization enzyme C; Region: DszC; cd01163 62977001218 Flavin binding site [chemical binding]; other site 62977001219 Dibenzothiophene (DBT) desulfurization enzyme C; Region: DszC; cd01163 62977001220 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 62977001221 Flavin binding site [chemical binding]; other site 62977001222 multidrug efflux protein; Reviewed; Region: PRK01766 62977001223 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 62977001224 cation binding site [ion binding]; other site 62977001225 Protein of unknown function, DUF606; Region: DUF606; pfam04657 62977001226 HemN family oxidoreductase; Provisional; Region: PRK05660 62977001227 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 62977001228 FeS/SAM binding site; other site 62977001229 HemN C-terminal domain; Region: HemN_C; pfam06969 62977001230 short chain dehydrogenase; Provisional; Region: PRK12744 62977001231 tetrahydroxynaphthalene/trihydroxynaphthalene reductase-like, classical (c) SDRs; Region: THN_reductase-like_SDR_c; cd05362 62977001232 NADP binding site [chemical binding]; other site 62977001233 homodimer interface [polypeptide binding]; other site 62977001234 active site 62977001235 substrate binding site [chemical binding]; other site 62977001236 Transcriptional regulator [Transcription]; Region: LysR; COG0583 62977001237 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 62977001238 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 62977001239 putative effector binding pocket; other site 62977001240 putative dimerization interface [polypeptide binding]; other site 62977001241 peroxiredoxin; Region: AhpC; TIGR03137 62977001242 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 62977001243 dimer interface [polypeptide binding]; other site 62977001244 decamer (pentamer of dimers) interface [polypeptide binding]; other site 62977001245 catalytic triad [active] 62977001246 peroxidatic and resolving cysteines [active] 62977001247 long-chain-acyl-CoA synthetase; Validated; Region: PRK08279 62977001248 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 62977001249 Fatty acid transport proteins (FATP) play dual roles as fatty acid transporters and its activation enzymes; Region: FATP_FACS; cd05940 62977001250 acyl-activating enzyme (AAE) consensus motif; other site 62977001251 putative AMP binding site [chemical binding]; other site 62977001252 putative active site [active] 62977001253 putative CoA binding site [chemical binding]; other site 62977001254 Ribonucleases G and E [Translation, ribosomal structure and biogenesis]; Region: CafA; COG1530 62977001255 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 62977001256 homodimer interface [polypeptide binding]; other site 62977001257 oligonucleotide binding site [chemical binding]; other site 62977001258 23S rRNA pseudouridylate synthase C; Provisional; Region: PRK11025 62977001259 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 62977001260 RNA binding surface [nucleotide binding]; other site 62977001261 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 62977001262 active site 62977001263 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 62977001264 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 62977001265 motif II; other site 62977001266 Predicted transcriptional regulator [Transcription]; Region: COG2378 62977001267 HTH domain; Region: HTH_11; pfam08279 62977001268 WYL domain; Region: WYL; pfam13280 62977001269 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 62977001270 GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046 62977001271 putative C-terminal domain interface [polypeptide binding]; other site 62977001272 putative GSH binding site (G-site) [chemical binding]; other site 62977001273 putative dimer interface [polypeptide binding]; other site 62977001274 C-terminal, alpha helical domain of an unknown subfamily 8 of Glutathione S-transferases; Region: GST_C_8; cd03207 62977001275 dimer interface [polypeptide binding]; other site 62977001276 N-terminal domain interface [polypeptide binding]; other site 62977001277 putative substrate binding pocket (H-site) [chemical binding]; other site 62977001278 Protein of unknown function (DUF1345); Region: DUF1345; pfam07077 62977001279 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 62977001280 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 62977001281 The C-terminal substrate binding domain of LysR-type transcriptional regulator HcaR in involved in 3-phenylpropionic acid catabolism, contains the type2 periplasmic binding fold; Region: PBP2_HcaR; cd08450 62977001282 putative dimerization interface [polypeptide binding]; other site 62977001283 putative substrate binding pocket [chemical binding]; other site 62977001284 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 62977001285 Cation efflux family; Region: Cation_efflux; pfam01545 62977001286 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 62977001287 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 62977001288 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 62977001289 Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156 62977001290 tetramer interface [polypeptide binding]; other site 62977001291 heme binding pocket [chemical binding]; other site 62977001292 NADPH binding site [chemical binding]; other site 62977001293 isovaleryl CoA dehydrogenase; Provisional; Region: PRK11561 62977001294 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 62977001295 active site 62977001296 Signal transduction protein containing GAF and PtsI domains [Signal transduction mechanisms]; Region: PtsP; COG3605 62977001297 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 62977001298 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 62977001299 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 62977001300 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 62977001301 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671 62977001302 putative active site [active] 62977001303 Ap4A binding site [chemical binding]; other site 62977001304 nudix motif; other site 62977001305 putative metal binding site [ion binding]; other site 62977001306 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 62977001307 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 62977001308 Transcriptional regulator [Transcription]; Region: LysR; COG0583 62977001309 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 62977001310 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 62977001311 dimerization interface [polypeptide binding]; other site 62977001312 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 62977001313 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 62977001314 [2Fe-2S] cluster binding site [ion binding]; other site 62977001315 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 62977001316 hydrophobic ligand binding site; other site 62977001317 5-histidylcysteine sulfoxide synthase; Region: ovoA_Nterm; TIGR04344 62977001318 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 62977001319 Methyltransferase domain; Region: Methyltransf_31; pfam13847 62977001320 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 62977001321 S-adenosylmethionine binding site [chemical binding]; other site 62977001322 Transcriptional regulator [Transcription]; Region: LysR; COG0583 62977001323 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 62977001324 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 62977001325 dimerization interface [polypeptide binding]; other site 62977001326 Predicted membrane protein (DUF2061); Region: DUF2061; pfam09834 62977001327 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 62977001328 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 62977001329 substrate binding site [chemical binding]; other site 62977001330 ligand binding site [chemical binding]; other site 62977001331 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 62977001332 GST_N family, unknown subfamily 1; composed of uncharacterized proteins, predominantly from bacteria, with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with...; Region: GST_N_1; cd03043 62977001333 putative C-terminal domain interface [polypeptide binding]; other site 62977001334 putative GSH binding site (G-site) [chemical binding]; other site 62977001335 putative dimer interface [polypeptide binding]; other site 62977001336 C-terminal, alpha helical domain of an unknown subfamily 3 of Glutathione S-transferases; Region: GST_C_3; cd03194 62977001337 putative N-terminal domain interface [polypeptide binding]; other site 62977001338 putative dimer interface [polypeptide binding]; other site 62977001339 putative substrate binding pocket (H-site) [chemical binding]; other site 62977001340 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 62977001341 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 62977001342 substrate binding site [chemical binding]; other site 62977001343 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 62977001344 tartrate dehydrogenase; Region: TTC; TIGR02089 62977001345 Protein of unknown function (DUF1311); Region: DUF1311; cl01530 62977001346 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 62977001347 rRNA binding site [nucleotide binding]; other site 62977001348 predicted 30S ribosome binding site; other site 62977001349 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 62977001350 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 62977001351 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 62977001352 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 62977001353 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 62977001354 dimerization interface 3.5A [polypeptide binding]; other site 62977001355 active site 62977001356 Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963 62977001357 active site 62977001358 homodimer interface [polypeptide binding]; other site 62977001359 aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK06598 62977001360 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 62977001361 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 62977001362 putative catalytic site [active] 62977001363 putative phosphate binding site [ion binding]; other site 62977001364 putative metal binding site [ion binding]; other site 62977001365 glutamate/aspartate:proton symporter; Provisional; Region: gltP; PRK11283 62977001366 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 62977001367 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 62977001368 This family is most closely related to the GT1 family of glycosyltransferases. WavL in Vibrio cholerae has been shown to be involved in the biosynthesis of the lipopolysaccharide core; Region: GT1_WavL_like; cd03819 62977001369 putative ADP-binding pocket [chemical binding]; other site 62977001370 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 62977001371 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 62977001372 putative acyl-acceptor binding pocket; other site 62977001373 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 62977001374 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 62977001375 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 62977001376 ABC transporter ATPase component; Reviewed; Region: PRK11147 62977001377 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 62977001378 Walker A/P-loop; other site 62977001379 ATP binding site [chemical binding]; other site 62977001380 ABC transporter signature motif; other site 62977001381 Walker B; other site 62977001382 D-loop; other site 62977001383 H-loop/switch region; other site 62977001384 ABC transporter; Region: ABC_tran_2; pfam12848 62977001385 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 62977001386 SlyX; Region: SlyX; pfam04102 62977001387 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 62977001388 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 62977001389 active site 62977001390 interdomain interaction site; other site 62977001391 putative metal-binding site [ion binding]; other site 62977001392 nucleotide binding site [chemical binding]; other site 62977001393 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 62977001394 domain I; other site 62977001395 DNA binding groove [nucleotide binding] 62977001396 phosphate binding site [ion binding]; other site 62977001397 domain II; other site 62977001398 domain III; other site 62977001399 nucleotide binding site [chemical binding]; other site 62977001400 catalytic site [active] 62977001401 domain IV; other site 62977001402 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 62977001403 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 62977001404 Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272 62977001405 Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272 62977001406 Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247 62977001407 acid-resistance membrane protein; Provisional; Region: PRK10209 62977001408 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 62977001409 Part of AAA domain; Region: AAA_19; pfam13245 62977001410 Family description; Region: UvrD_C_2; pfam13538 62977001411 RNA recognition motif; Region: RRM; smart00360 62977001412 ASCH domain; Region: ASCH; pfam04266 62977001413 putative cation:proton antiport protein; Provisional; Region: PRK10669 62977001414 Kef-type K+ transport system, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: RosB; COG4651 62977001415 TrkA-N domain; Region: TrkA_N; pfam02254 62977001416 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 62977001417 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 62977001418 aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381 62977001419 Coniferyl aldehyde dehydrogenase-like; Region: ALDH_CALDH_CalB; cd07133 62977001420 NAD(P) binding site [chemical binding]; other site 62977001421 catalytic residues [active] 62977001422 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 62977001423 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 62977001424 Bacterial transcriptional repressor; Region: TetR; pfam13972 62977001425 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 62977001426 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 62977001427 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 62977001428 putative active site [active] 62977001429 putative substrate binding site [chemical binding]; other site 62977001430 putative cosubstrate binding site; other site 62977001431 catalytic site [active] 62977001432 TonB family C-terminal domain; Region: tonB_Cterm; TIGR01352 62977001433 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 62977001434 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 62977001435 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 62977001436 methionine sulfoxide reductase A; Provisional; Region: PRK14054 62977001437 META domain; Region: META; pfam03724 62977001438 Domain of unknown function (DUF4105); Region: DUF4105; pfam13387 62977001439 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 62977001440 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 62977001441 folate binding site [chemical binding]; other site 62977001442 NADP+ binding site [chemical binding]; other site 62977001443 thymidylate synthase; Reviewed; Region: thyA; PRK01827 62977001444 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 62977001445 dimerization interface [polypeptide binding]; other site 62977001446 active site 62977001447 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK12437 62977001448 NRDE protein; Region: NRDE; cl01315 62977001449 Bacterial protein of unknown function (DUF839); Region: DUF839; pfam05787 62977001450 Sec-independent protein translocase protein (TatC); Region: TatC; cl00521 62977001451 twin arginine-targeting protein translocase TatB; Region: tatB; TIGR01410 62977001452 twin arginine translocase protein A; Provisional; Region: tatA; PRK02958 62977001453 Membrane transport protein; Region: Mem_trans; cl09117 62977001454 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 62977001455 active site 62977001456 dimerization interface [polypeptide binding]; other site 62977001457 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 62977001458 Sel1-like repeats; Region: SEL1; smart00671 62977001459 Sel1-like repeats; Region: SEL1; smart00671 62977001460 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 62977001461 S-adenosylmethionine binding site [chemical binding]; other site 62977001462 homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175 62977001463 homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392 62977001464 2-isopropylmalate synthase; Validated; Region: PRK03739 62977001465 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 62977001466 active site 62977001467 catalytic residues [active] 62977001468 metal binding site [ion binding]; metal-binding site 62977001469 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 62977001470 Fe(II)-dependent oxygenase superfamily protein; Provisional; Region: PRK05467 62977001471 Outer membrane receptor for monomeric catechols [Inorganic ion transport and metabolism]; Region: Fiu; COG4774 62977001472 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 62977001473 N-terminal plug; other site 62977001474 ligand-binding site [chemical binding]; other site 62977001475 trigger factor; Provisional; Region: tig; PRK01490 62977001476 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 62977001477 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 62977001478 Clp protease; Region: CLP_protease; pfam00574 62977001479 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 62977001480 oligomer interface [polypeptide binding]; other site 62977001481 active site residues [active] 62977001482 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 62977001483 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 62977001484 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 62977001485 Walker A motif; other site 62977001486 ATP binding site [chemical binding]; other site 62977001487 Walker B motif; other site 62977001488 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 62977001489 Protein of unknown function (DUF2846); Region: DUF2846; pfam11008 62977001490 Uncharacterized protein conserved in bacteria (DUF2059); Region: DUF2059; pfam09832 62977001491 Fumarate hydratase (Fumerase); Region: Fumerase; pfam05681 62977001492 Fumarase C-terminus; Region: Fumerase_C; pfam05683 62977001493 Methyltransferase domain; Region: Methyltransf_23; pfam13489 62977001494 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 62977001495 S-adenosylmethionine binding site [chemical binding]; other site 62977001496 phosphate acetyltransferase; Reviewed; Region: PRK05632 62977001497 DRTGG domain; Region: DRTGG; pfam07085 62977001498 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 62977001499 propionate/acetate kinase; Provisional; Region: PRK12379 62977001500 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 62977001501 nucleotide binding site [chemical binding]; other site 62977001502 phosphogluconate dehydratase; Validated; Region: PRK09054 62977001503 6-phosphogluconate dehydratase; Region: edd; TIGR01196 62977001504 keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718 62977001505 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 62977001506 active site 62977001507 intersubunit interface [polypeptide binding]; other site 62977001508 catalytic residue [active] 62977001509 fructuronate transporter; Provisional; Region: PRK10034; cl15264 62977001510 GntP family permease; Region: GntP_permease; pfam02447 62977001511 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 62977001512 ATP-binding site [chemical binding]; other site 62977001513 Gluconate-6-phosphate binding site [chemical binding]; other site 62977001514 Shikimate kinase; Region: SKI; pfam01202 62977001515 NADP+-dependent non-phosphorylating glyceraldehyde 3-phosphate dehydrogenase and ALDH family 11; Region: ALDH_F11_NP-GAPDH; cd07082 62977001516 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 62977001517 tetrameric interface [polypeptide binding]; other site 62977001518 activator binding site; other site 62977001519 NADP binding site [chemical binding]; other site 62977001520 substrate binding site [chemical binding]; other site 62977001521 catalytic residues [active] 62977001522 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 62977001523 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 62977001524 putative catalytic cysteine [active] 62977001525 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 62977001526 Leucine carboxyl methyltransferase; Region: LCM; cl01306 62977001527 beta-hexosaminidase; Provisional; Region: PRK05337 62977001528 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 62977001529 carboxy-terminal protease; Provisional; Region: PRK11186 62977001530 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 62977001531 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 62977001532 protein binding site [polypeptide binding]; other site 62977001533 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 62977001534 Catalytic dyad [active] 62977001535 C-terminal domain of tail specific protease (DUF3340); Region: DUF3340; pfam11818 62977001536 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 62977001537 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 62977001538 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 62977001539 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 62977001540 active site 62977001541 Iron-sulphur cluster assembly; Region: Fe-S_assembly; pfam04384 62977001542 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 62977001543 active site 62977001544 multimer interface [polypeptide binding]; other site 62977001545 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK11194 62977001546 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 62977001547 FeS/SAM binding site; other site 62977001548 type IV pilus biogenesis/stability protein PilW; Region: type_IV_pilW; TIGR02521 62977001549 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 62977001550 binding surface 62977001551 TPR motif; other site 62977001552 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 62977001553 binding surface 62977001554 TPR motif; other site 62977001555 Helix-turn-helix domain; Region: HTH_25; pfam13413 62977001556 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 62977001557 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 62977001558 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 62977001559 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 62977001560 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 62977001561 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 62977001562 dimer interface [polypeptide binding]; other site 62977001563 motif 1; other site 62977001564 active site 62977001565 motif 2; other site 62977001566 motif 3; other site 62977001567 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 62977001568 anticodon binding site; other site 62977001569 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2976 62977001570 Uncharacterized protein conserved in bacteria (DUF2133); Region: DUF2133; pfam09976 62977001571 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 62977001572 binding surface 62977001573 TPR motif; other site 62977001574 outer membrane assembly lipoprotein YfgL; Region: assembly_YfgL; TIGR03300 62977001575 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 62977001576 Trp docking motif [polypeptide binding]; other site 62977001577 active site 62977001578 GTP-binding protein Der; Reviewed; Region: PRK00093 62977001579 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 62977001580 G1 box; other site 62977001581 GTP/Mg2+ binding site [chemical binding]; other site 62977001582 Switch I region; other site 62977001583 G2 box; other site 62977001584 Switch II region; other site 62977001585 G3 box; other site 62977001586 G4 box; other site 62977001587 G5 box; other site 62977001588 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 62977001589 G1 box; other site 62977001590 GTP/Mg2+ binding site [chemical binding]; other site 62977001591 Switch I region; other site 62977001592 G2 box; other site 62977001593 G3 box; other site 62977001594 Switch II region; other site 62977001595 G4 box; other site 62977001596 G5 box; other site 62977001597 Beta-ketoacyl synthase, N-terminal domain; Region: Ketoacyl-synt_2; pfam13723 62977001598 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 62977001599 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 62977001600 putative acyl-acceptor binding pocket; other site 62977001601 Phosphopantetheine attachment site; Region: PP-binding; cl09936 62977001602 acyl carrier protein; Provisional; Region: PRK05350 62977001603 Predicted membrane protein [Function unknown]; Region: COG4648 62977001604 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 62977001605 O-succinylbenzoate-CoA ligase; Region: menE; TIGR01923 62977001606 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 62977001607 acyl-activating enzyme (AAE) consensus motif; other site 62977001608 acyl-activating enzyme (AAE) consensus motif; other site 62977001609 active site 62977001610 AMP binding site [chemical binding]; other site 62977001611 CoA binding site [chemical binding]; other site 62977001612 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 62977001613 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 62977001614 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 62977001615 Ligand binding site; other site 62977001616 Putative Catalytic site; other site 62977001617 DXD motif; other site 62977001618 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 62977001619 putative acyl-acceptor binding pocket; other site 62977001620 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 62977001621 active sites [active] 62977001622 tetramer interface [polypeptide binding]; other site 62977001623 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 62977001624 active site 62977001625 Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl17548 62977001626 Predicted exporter [General function prediction only]; Region: COG4258 62977001627 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 62977001628 3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK09185 62977001629 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 62977001630 dimer interface [polypeptide binding]; other site 62977001631 active site 62977001632 Domain of unknown function, appears to be related to a diverse group of beta-hydroxydecanoyl ACP dehydratases (FabA) and beta-hydroxyacyl ACP dehydratases (FabZ). This group appears to lack the conserved active site histidine of FabA and FabZ; Region: FabA_like; cd01289 62977001633 putative active site 1 [active] 62977001634 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 62977001635 3-oxoacyl-(acyl-carrier-protein) reductase, putative; Region: fabG_rel; TIGR01831 62977001636 NAD(P) binding site [chemical binding]; other site 62977001637 homotetramer interface [polypeptide binding]; other site 62977001638 homodimer interface [polypeptide binding]; other site 62977001639 active site 62977001640 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK09116 62977001641 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 62977001642 dimer interface [polypeptide binding]; other site 62977001643 active site 62977001644 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 62977001645 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 62977001646 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 62977001647 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 62977001648 Protein export membrane protein; Region: SecD_SecF; pfam02355 62977001649 SecD export protein N-terminal TM region; Region: SecD-TM1; pfam13721 62977001650 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 62977001651 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 62977001652 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 62977001653 preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585 62977001654 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 62977001655 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 62977001656 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 62977001657 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 62977001658 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 62977001659 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 62977001660 dimer interface [polypeptide binding]; other site 62977001661 phosphorylation site [posttranslational modification] 62977001662 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 62977001663 ATP binding site [chemical binding]; other site 62977001664 Mg2+ binding site [ion binding]; other site 62977001665 G-X-G motif; other site 62977001666 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Reviewed; Region: PRK11072 62977001667 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 62977001668 metal binding triad; other site 62977001669 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 62977001670 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 62977001671 metal binding triad; other site 62977001672 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 62977001673 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 62977001674 homodimer interface [polypeptide binding]; other site 62977001675 substrate-cofactor binding pocket; other site 62977001676 catalytic residue [active] 62977001677 Predicted nucleoside-diphosphate-sugar epimerase [Cell envelope biogenesis, outer membrane]; Region: COG3660 62977001678 Mitochondrial fission ELM1; Region: Mito_fiss_Elm1; pfam06258 62977001679 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 62977001680 phosphorylation site [posttranslational modification] 62977001681 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 62977001682 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 62977001683 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 62977001684 putative active site [active] 62977001685 putative metal binding site [ion binding]; other site 62977001686 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 62977001687 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 62977001688 putative metal binding site; other site 62977001689 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 62977001690 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 62977001691 putative ADP-binding pocket [chemical binding]; other site 62977001692 Glycosyltransferase family 25 [lipooligosaccharide (LOS) biosynthesis protein] is a family of glycosyltransferases involved in LOS biosynthesis. The members include the beta(1,4) galactosyltransferases: Lgt2 of Moraxella catarrhalis, LgtB and LgtE of...; Region: Glyco_transf_25; cd06532 62977001693 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 62977001694 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 62977001695 active site 62977001696 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 62977001697 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 62977001698 dimer interface [polypeptide binding]; other site 62977001699 anticodon binding site; other site 62977001700 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 62977001701 homodimer interface [polypeptide binding]; other site 62977001702 motif 1; other site 62977001703 active site 62977001704 motif 2; other site 62977001705 GAD domain; Region: GAD; pfam02938 62977001706 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 62977001707 active site 62977001708 motif 3; other site 62977001709 Domain of unknown function (DUF4184); Region: DUF4184; pfam13803 62977001710 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 62977001711 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 62977001712 N-terminal plug; other site 62977001713 ligand-binding site [chemical binding]; other site 62977001714 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 62977001715 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 62977001716 N-terminal plug; other site 62977001717 ligand-binding site [chemical binding]; other site 62977001718 Putative catalytic domain, repeat 1, of uncharacterized phospholipase D-like proteins; Region: PLDc_unchar2_1; cd09129 62977001719 putative active site [active] 62977001720 putative catalytic site [active] 62977001721 Putative catalytic domain, repeat 2, of uncharacterized phospholipase D-like proteins; Region: PLDc_unchar2_2; cd09130 62977001722 PLD-like domain; Region: PLDc_2; pfam13091 62977001723 putative active site [active] 62977001724 putative catalytic site [active] 62977001725 Domain of unknown function (DUF3315); Region: DUF3315; pfam11776 62977001726 Domain of unknown function (DUF3315); Region: DUF3315; pfam11776 62977001727 Domain of unknown function (DUF3315); Region: DUF3315; pfam11776 62977001728 Predicted membrane protein [Function unknown]; Region: COG3223 62977001729 Putative FMN-binding domain; Region: FMN_bind_2; pfam04299 62977001730 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 62977001731 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 62977001732 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 62977001733 active site 62977001734 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 62977001735 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 62977001736 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 62977001737 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 62977001738 active site 62977001739 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 62977001740 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 62977001741 dimerization interface [polypeptide binding]; other site 62977001742 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 62977001743 dimer interface [polypeptide binding]; other site 62977001744 phosphorylation site [posttranslational modification] 62977001745 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 62977001746 ATP binding site [chemical binding]; other site 62977001747 Mg2+ binding site [ion binding]; other site 62977001748 G-X-G motif; other site 62977001749 DNA-binding transcriptional regulator BaeR; Provisional; Region: PRK10710 62977001750 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 62977001751 active site 62977001752 phosphorylation site [posttranslational modification] 62977001753 intermolecular recognition site; other site 62977001754 dimerization interface [polypeptide binding]; other site 62977001755 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 62977001756 DNA binding site [nucleotide binding] 62977001757 Uncharacterized protein conserved in bacteria [Function unknown]; Region: MmcQ; COG2315 62977001758 Uncharacterized conserved protein [Function unknown]; Region: COG0397 62977001759 hypothetical protein; Validated; Region: PRK00029 62977001760 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 62977001761 Fatty acid desaturase; Region: FA_desaturase; pfam00487 62977001762 Di-iron ligands [ion binding]; other site 62977001763 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 62977001764 META domain; Region: META; pfam03724 62977001765 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 62977001766 Glycerophosphodiester phosphodiesterase domain as found in prokaryota and eukaryota, and similar proteins; Region: GDPD; cd08556 62977001767 active site 62977001768 catalytic site [active] 62977001769 metal binding site [ion binding]; metal-binding site 62977001770 Cobalamin adenosyltransferase; Region: Cob_adeno_trans; pfam01923 62977001771 Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206 62977001772 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 62977001773 N-terminal plug; other site 62977001774 ligand-binding site [chemical binding]; other site 62977001775 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 62977001776 active site 62977001777 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 62977001778 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 62977001779 pyridoxal 5'-phosphate binding site [chemical binding]; other site 62977001780 catalytic residue [active] 62977001781 Domain of Unknown Function (DUF1543); Region: DUF1543; pfam07566 62977001782 Protein of unknown function (DUF2804); Region: DUF2804; pfam10974 62977001783 Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118 62977001784 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687 62977001785 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 62977001786 Helix-turn-helix domain; Region: HTH_18; pfam12833 62977001787 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 62977001788 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 62977001789 substrate binding site [chemical binding]; other site 62977001790 active site 62977001791 catalytic residues [active] 62977001792 heterodimer interface [polypeptide binding]; other site 62977001793 Acetyl-CoA carboxylase beta subunit [Lipid metabolism]; Region: AccD; COG0777 62977001794 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 62977001795 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 62977001796 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 62977001797 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 62977001798 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 62977001799 Peroxiredoxin (PRX) family, 1-cys PRX subfamily; composed of PRXs containing only one conserved cysteine, which serves as the peroxidatic cysteine. They are homodimeric thiol-specific antioxidant (TSA) proteins that confer a protective role in cells by...; Region: PRX_1cys; cd03016 62977001800 dimer interface [polypeptide binding]; other site 62977001801 decamer (pentamer of dimers) interface [polypeptide binding]; other site 62977001802 catalytic triad [active] 62977001803 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 62977001804 DEAD/DEAH box helicase; Region: DEAD; pfam00270 62977001805 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 62977001806 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 62977001807 nucleotide binding region [chemical binding]; other site 62977001808 ATP-binding site [chemical binding]; other site 62977001809 SEC-C motif; Region: SEC-C; pfam02810 62977001810 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 62977001811 heterotetramer interface [polypeptide binding]; other site 62977001812 active site pocket [active] 62977001813 cleavage site 62977001814 quinolinate synthetase; Provisional; Region: PRK09375 62977001815 putative outer membrane lipoprotein; Provisional; Region: PRK09967 62977001816 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 62977001817 ligand binding site [chemical binding]; other site 62977001818 putative inner membrane diguanylate cyclase; Provisional; Region: PRK09966 62977001819 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 62977001820 metal binding site [ion binding]; metal-binding site 62977001821 active site 62977001822 I-site; other site 62977001823 Domain of unknown function (DUF4154); Region: DUF4154; pfam13689 62977001824 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 62977001825 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 62977001826 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 62977001827 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 62977001828 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 62977001829 30S subunit binding site; other site 62977001830 BolA-like protein; Region: BolA; cl00386 62977001831 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 62977001832 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 62977001833 hinge; other site 62977001834 active site 62977001835 ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040 62977001836 ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686 62977001837 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 62977001838 histidinol dehydrogenase; Region: hisD; TIGR00069 62977001839 NAD binding site [chemical binding]; other site 62977001840 dimerization interface [polypeptide binding]; other site 62977001841 product binding site; other site 62977001842 substrate binding site [chemical binding]; other site 62977001843 zinc binding site [ion binding]; other site 62977001844 catalytic residues [active] 62977001845 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 62977001846 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 62977001847 pyridoxal 5'-phosphate binding site [chemical binding]; other site 62977001848 homodimer interface [polypeptide binding]; other site 62977001849 catalytic residue [active] 62977001850 anthranilate synthase component I, non-proteobacterial lineages; Region: trpE_most; TIGR00564 62977001851 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 62977001852 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39G; cd02423 62977001853 putative active site [active] 62977001854 Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; cl17479 62977001855 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 62977001856 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_4; cd04511 62977001857 nudix motif; other site 62977001858 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 62977001859 putative active site [active] 62977001860 putative CoA binding site [chemical binding]; other site 62977001861 nudix motif; other site 62977001862 metal binding site [ion binding]; metal-binding site 62977001863 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 62977001864 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 62977001865 trimer interface [polypeptide binding]; other site 62977001866 putative metal binding site [ion binding]; other site 62977001867 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 62977001868 Glycoprotease family; Region: Peptidase_M22; pfam00814 62977001869 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 62977001870 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 62977001871 S-adenosylmethionine binding site [chemical binding]; other site 62977001872 Peptidase C13 family; Region: Peptidase_C13; pfam01650 62977001873 S-formylglutathione hydrolase; Region: PLN02442 62977001874 S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821 62977001875 Uncharacterized protein conserved in bacteria (DUF2218); Region: DUF2218; pfam09981 62977001876 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 62977001877 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 62977001878 substrate binding site [chemical binding]; other site 62977001879 hexamer interface [polypeptide binding]; other site 62977001880 metal binding site [ion binding]; metal-binding site 62977001881 copper-resistance protein, CopA family; Region: copper_res_A; TIGR01480 62977001882 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 62977001883 Multicopper oxidase; Region: Cu-oxidase; pfam00394 62977001884 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 62977001885 Copper resistance protein B precursor (CopB); Region: CopB; pfam05275 62977001886 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 62977001887 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 62977001888 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 62977001889 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 62977001890 DNA binding site [nucleotide binding] 62977001891 active site 62977001892 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 62977001893 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 62977001894 dimer interface [polypeptide binding]; other site 62977001895 acetyl-CoA acetyltransferase; Provisional; Region: PRK06954 62977001896 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 62977001897 dimer interface [polypeptide binding]; other site 62977001898 active site 62977001899 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 62977001900 Type II transport protein GspH; Region: GspH; pfam12019 62977001901 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 62977001902 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 62977001903 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 62977001904 ligand binding site [chemical binding]; other site 62977001905 lysine transporter; Provisional; Region: PRK10836 62977001906 Methyltransferase small domain N-terminal; Region: MTS_N; pfam08468 62977001907 16S RNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; Region: RsmC; COG2813 62977001908 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 62977001909 S-adenosylmethionine binding site [chemical binding]; other site 62977001910 Xanthine/uracil permeases [Nucleotide transport and metabolism]; Region: UraA; COG2233 62977001911 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 62977001912 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 62977001913 G1 box; other site 62977001914 putative GEF interaction site [polypeptide binding]; other site 62977001915 GTP/Mg2+ binding site [chemical binding]; other site 62977001916 Switch I region; other site 62977001917 G2 box; other site 62977001918 G3 box; other site 62977001919 Switch II region; other site 62977001920 G4 box; other site 62977001921 G5 box; other site 62977001922 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 62977001923 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 62977001924 large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13952 62977001925 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 62977001926 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 62977001927 putative active site pocket [active] 62977001928 dimerization interface [polypeptide binding]; other site 62977001929 putative catalytic residue [active] 62977001930 PPIC-type PPIASE domain; Region: Rotamase_2; cl08278 62977001931 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 62977001932 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 62977001933 DNA binding site [nucleotide binding] 62977001934 catalytic residue [active] 62977001935 H2TH interface [polypeptide binding]; other site 62977001936 putative catalytic residues [active] 62977001937 turnover-facilitating residue; other site 62977001938 intercalation triad [nucleotide binding]; other site 62977001939 8OG recognition residue [nucleotide binding]; other site 62977001940 putative reading head residues; other site 62977001941 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 62977001942 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 62977001943 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 62977001944 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 62977001945 N-terminal plug; other site 62977001946 ligand-binding site [chemical binding]; other site 62977001947 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 62977001948 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 62977001949 active site 62977001950 FMN binding site [chemical binding]; other site 62977001951 substrate binding site [chemical binding]; other site 62977001952 homotetramer interface [polypeptide binding]; other site 62977001953 catalytic residue [active] 62977001954 Predicted permeases [General function prediction only]; Region: COG0679 62977001955 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 62977001956 Sel1-like repeats; Region: SEL1; smart00671 62977001957 Sel1 repeat; Region: Sel1; cl02723 62977001958 protein disulfide isomerase II DsbC; Provisional; Region: PRK10877 62977001959 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020 62977001960 dimerization domain [polypeptide binding]; other site 62977001961 dimer interface [polypeptide binding]; other site 62977001962 catalytic residues [active] 62977001963 Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354 62977001964 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 62977001965 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 62977001966 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 62977001967 active site 62977001968 Protein of unknown function (DUF1260); Region: DUF1260; pfam06877 62977001969 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_2; cd08895 62977001970 putative hydrophobic ligand binding site [chemical binding]; other site 62977001971 Protein of unknown function (DUF2939); Region: DUF2939; pfam11159 62977001972 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 62977001973 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 62977001974 PhnA protein; Region: PhnA; pfam03831 62977001975 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_21; cd04680 62977001976 nudix motif; other site 62977001977 Uncharacterized conserved protein [Function unknown]; Region: COG3422 62977001978 Domain of unknown function (DUF1508); Region: DUF1508; pfam07411 62977001979 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 62977001980 dimer interface [polypeptide binding]; other site 62977001981 putative radical transfer pathway; other site 62977001982 diiron center [ion binding]; other site 62977001983 tyrosyl radical; other site 62977001984 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07207 62977001985 ATP cone domain; Region: ATP-cone; pfam03477 62977001986 ATP cone domain; Region: ATP-cone; pfam03477 62977001987 Class I ribonucleotide reductase; Region: RNR_I; cd01679 62977001988 active site 62977001989 dimer interface [polypeptide binding]; other site 62977001990 catalytic residues [active] 62977001991 effector binding site; other site 62977001992 R2 peptide binding site; other site 62977001993 DNA-binding transcriptional regulator RstA; Provisional; Region: PRK10701 62977001994 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 62977001995 active site 62977001996 phosphorylation site [posttranslational modification] 62977001997 intermolecular recognition site; other site 62977001998 dimerization interface [polypeptide binding]; other site 62977001999 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 62977002000 DNA binding site [nucleotide binding] 62977002001 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 62977002002 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 62977002003 dimerization interface [polypeptide binding]; other site 62977002004 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 62977002005 dimer interface [polypeptide binding]; other site 62977002006 phosphorylation site [posttranslational modification] 62977002007 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 62977002008 ATP binding site [chemical binding]; other site 62977002009 Mg2+ binding site [ion binding]; other site 62977002010 G-X-G motif; other site 62977002011 NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602 62977002012 NADH dehydrogenase subunit B; Validated; Region: PRK06411 62977002013 bifunctional NADH:ubiquinone oxidoreductase subunit C/D; Provisional; Region: PRK11742 62977002014 NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961 62977002015 NADH dehydrogenase subunit D; Validated; Region: PRK06075 62977002016 NADH dehydrogenase subunit E; Validated; Region: PRK07539 62977002017 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 62977002018 putative dimer interface [polypeptide binding]; other site 62977002019 [2Fe-2S] cluster binding site [ion binding]; other site 62977002020 NADH dehydrogenase I subunit F; Provisional; Region: PRK11278 62977002021 SLBB domain; Region: SLBB; pfam10531 62977002022 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 62977002023 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 62977002024 NADH-quinone oxidoreductase, chain G; Region: NuoG; TIGR01973 62977002025 catalytic loop [active] 62977002026 iron binding site [ion binding]; other site 62977002027 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 62977002028 MopB_NDH-1_NuoG2-N7: The second domain of the NuoG subunit (with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex in the respiratory...; Region: MopB_NDH-1_NuoG2-N7; cd02771 62977002029 [4Fe-4S] binding site [ion binding]; other site 62977002030 MopB_CT_NDH-1_NuoG2-N7: C-terminal region of the NuoG-like subunit (of the variant with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex...; Region: MopB_CT_NDH-1_NuoG2-N7; cd02788 62977002031 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 62977002032 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 62977002033 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 62977002034 4Fe-4S binding domain; Region: Fer4; pfam00037 62977002035 4Fe-4S binding domain; Region: Fer4; pfam00037 62977002036 NADH:ubiquinone oxidoreductase subunit 6 (chain J) [Energy production and conversion]; Region: NuoJ; COG0839 62977002037 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 62977002038 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 62977002039 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 62977002040 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 62977002041 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 62977002042 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 62977002043 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 62977002044 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 62977002045 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 62977002046 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 62977002047 active site 62977002048 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 62977002049 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 62977002050 N-terminal plug; other site 62977002051 ligand-binding site [chemical binding]; other site 62977002052 putative DNA-binding transcriptional regulator; Provisional; Region: PRK10837 62977002053 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 62977002054 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 62977002055 putative dimerization interface [polypeptide binding]; other site 62977002056 ferredoxin-NADP reductase; Provisional; Region: PRK10926 62977002057 Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195 62977002058 FAD binding pocket [chemical binding]; other site 62977002059 FAD binding motif [chemical binding]; other site 62977002060 phosphate binding motif [ion binding]; other site 62977002061 beta-alpha-beta structure motif; other site 62977002062 NAD binding pocket [chemical binding]; other site 62977002063 Conserved TM helix; Region: TM_helix; pfam05552 62977002064 Conserved TM helix; Region: TM_helix; pfam05552 62977002065 Conserved TM helix; Region: TM_helix; pfam05552 62977002066 Conserved TM helix; Region: TM_helix; pfam05552 62977002067 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 62977002068 HI0933-like protein; Region: HI0933_like; pfam03486 62977002069 Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl17341 62977002070 1-aminocyclopropane-1-carboxylate deaminase; Provisional; Region: PRK14045 62977002071 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 62977002072 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 62977002073 catalytic residue [active] 62977002074 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 62977002075 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 62977002076 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 62977002077 HlyD family secretion protein; Region: HlyD_3; pfam13437 62977002078 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 62977002079 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 62977002080 putative substrate translocation pore; other site 62977002081 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 62977002082 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 62977002083 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 62977002084 S-adenosylmethionine binding site [chemical binding]; other site 62977002085 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 62977002086 hydroxydechloroatrazine ethylaminohydrolase; Reviewed; Region: PRK08203 62977002087 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 62977002088 active site 62977002089 putative substrate binding pocket [chemical binding]; other site 62977002090 xanthine permease; Region: pbuX; TIGR03173 62977002091 Isopenicillin N synthase and related dioxygenases [General function prediction only]; Region: PcbC; COG3491 62977002092 non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226 62977002093 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171 62977002094 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 62977002095 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 62977002096 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 62977002097 methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133 62977002098 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 62977002099 active site 62977002100 HIGH motif; other site 62977002101 KMSKS motif; other site 62977002102 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 62977002103 tRNA binding surface [nucleotide binding]; other site 62977002104 anticodon binding site; other site 62977002105 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 62977002106 dimer interface [polypeptide binding]; other site 62977002107 putative tRNA-binding site [nucleotide binding]; other site 62977002108 nucleoside-specific channel-forming protein Tsx; Provisional; Region: PRK15106 62977002109 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 62977002110 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 62977002111 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 62977002112 Phosphorylase superfamily; Region: PNP_UDP_1; pfam01048 62977002113 Uncharacterized protein conserved in bacteria (DUF2062); Region: DUF2062; pfam09835 62977002114 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 62977002115 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 62977002116 trimer interface [polypeptide binding]; other site 62977002117 active site 62977002118 prolyl-tRNA synthetase; Provisional; Region: PRK09194 62977002119 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 62977002120 dimer interface [polypeptide binding]; other site 62977002121 motif 1; other site 62977002122 active site 62977002123 motif 2; other site 62977002124 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 62977002125 putative deacylase active site [active] 62977002126 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 62977002127 active site 62977002128 motif 3; other site 62977002129 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 62977002130 anticodon binding site; other site 62977002131 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 62977002132 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 62977002133 HlyD family secretion protein; Region: HlyD_3; pfam13437 62977002134 Response regulator receiver domain; Region: Response_reg; pfam00072 62977002135 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 62977002136 active site 62977002137 phosphorylation site [posttranslational modification] 62977002138 intermolecular recognition site; other site 62977002139 dimerization interface [polypeptide binding]; other site 62977002140 Response regulator receiver domain; Region: Response_reg; pfam00072 62977002141 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 62977002142 active site 62977002143 phosphorylation site [posttranslational modification] 62977002144 intermolecular recognition site; other site 62977002145 dimerization interface [polypeptide binding]; other site 62977002146 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 62977002147 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 62977002148 putative binding surface; other site 62977002149 active site 62977002150 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 62977002151 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 62977002152 putative binding surface; other site 62977002153 active site 62977002154 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 62977002155 ATP binding site [chemical binding]; other site 62977002156 Mg2+ binding site [ion binding]; other site 62977002157 G-X-G motif; other site 62977002158 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 62977002159 Response regulator receiver domain; Region: Response_reg; pfam00072 62977002160 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 62977002161 active site 62977002162 phosphorylation site [posttranslational modification] 62977002163 intermolecular recognition site; other site 62977002164 dimerization interface [polypeptide binding]; other site 62977002165 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009 62977002166 M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891 62977002167 metal binding site [ion binding]; metal-binding site 62977002168 dimer interface [polypeptide binding]; other site 62977002169 Predicted small secreted protein [Function unknown]; Region: COG5510 62977002170 Domain of unknown function (DUF1853); Region: DUF1853; cl01545 62977002171 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2832 62977002172 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 62977002173 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 62977002174 Protein of unknown function (DUF2750); Region: DUF2750; pfam11042 62977002175 Uncharacterized conserved protein [Function unknown]; Region: COG1434 62977002176 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 62977002177 putative active site [active] 62977002178 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 62977002179 PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172 62977002180 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 62977002181 Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; Region: CysJ; COG0369 62977002182 Flavodoxin; Region: Flavodoxin_1; pfam00258 62977002183 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR_like1; cd06200 62977002184 FAD binding pocket [chemical binding]; other site 62977002185 FAD binding motif [chemical binding]; other site 62977002186 catalytic residues [active] 62977002187 NAD binding pocket [chemical binding]; other site 62977002188 phosphate binding motif [ion binding]; other site 62977002189 beta-alpha-beta structure motif; other site 62977002190 YcxB-like protein; Region: YcxB; pfam14317 62977002191 FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805 62977002192 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 62977002193 bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102 62977002194 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 62977002195 putative substrate translocation pore; other site 62977002196 Nitroreductase family. Members of this family utilize FMN as a cofactor and catalyze reduction of a variety of nitroaromatic compounds, including nitrofurans, nitrobenzens, nitrophenol, nitrobenzoate and quinones by using either NADH or NADPH as a source...; Region: Nitroreductase; cd02136 62977002197 putative FMN binding site [chemical binding]; other site 62977002198 Na+/glutamate symporter [Amino acid transport and metabolism]; Region: GltS; COG0786 62977002199 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 62977002200 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 62977002201 hypothetical protein; Provisional; Region: PRK10279 62977002202 Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205 62977002203 active site 62977002204 nucleophile elbow; other site 62977002205 intracellular protease, PfpI family; Region: PfpI; TIGR01382 62977002206 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_1; cd03169 62977002207 conserved cys residue [active] 62977002208 microcin B17 transporter; Reviewed; Region: PRK11098 62977002209 Chromate transporter; Region: Chromate_transp; pfam02417 62977002210 Chromate transporter; Region: Chromate_transp; pfam02417 62977002211 Transcriptional regulator [Transcription]; Region: LysR; COG0583 62977002212 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 62977002213 The C-terminal substrate binding domain of LysR-type transcrptional regulator BudR, which is responsible for activation of the expression of the butanediol operon genes; contains the type 2 periplasmic binding fold; Region: PBP2_BudR; cd08451 62977002214 putative dimerization interface [polypeptide binding]; other site 62977002215 putative substrate binding pocket [chemical binding]; other site 62977002216 Protein of unknown function (DUF1176); Region: DUF1176; pfam06674 62977002217 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 62977002218 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 62977002219 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 62977002220 GatB domain; Region: GatB_Yqey; smart00845 62977002221 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 62977002222 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 62977002223 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 62977002224 rod shape-determining protein MreB; Provisional; Region: PRK13927 62977002225 MreB and similar proteins; Region: MreB_like; cd10225 62977002226 nucleotide binding site [chemical binding]; other site 62977002227 Mg binding site [ion binding]; other site 62977002228 putative protofilament interaction site [polypeptide binding]; other site 62977002229 RodZ interaction site [polypeptide binding]; other site 62977002230 rod shape-determining protein MreC; Provisional; Region: PRK13922 62977002231 rod shape-determining protein MreC; Region: MreC; pfam04085 62977002232 Maf-like protein; Region: Maf; pfam02545 62977002233 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 62977002234 active site 62977002235 dimer interface [polypeptide binding]; other site 62977002236 ribonuclease G; Provisional; Region: PRK11712 62977002237 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 62977002238 homodimer interface [polypeptide binding]; other site 62977002239 oligonucleotide binding site [chemical binding]; other site 62977002240 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 62977002241 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 62977002242 Protein of unknown function (DUF1298); Region: DUF1298; pfam06974 62977002243 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 62977002244 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 62977002245 Active Sites [active] 62977002246 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 62977002247 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 62977002248 motif II; other site 62977002249 Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; cl17479 62977002250 tRNA-dihydrouridine synthase C; Provisional; Region: PRK10550 62977002251 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 62977002252 FMN binding site [chemical binding]; other site 62977002253 active site 62977002254 catalytic residues [active] 62977002255 substrate binding site [chemical binding]; other site 62977002256 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 62977002257 signal recognition particle protein; Provisional; Region: PRK10867 62977002258 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 62977002259 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 62977002260 GTP binding site [chemical binding]; other site 62977002261 Signal peptide binding domain; Region: SRP_SPB; pfam02978 62977002262 pantothenate kinase; Reviewed; Region: PRK13322 62977002263 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 62977002264 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 62977002265 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 62977002266 Transcriptional regulators [Transcription]; Region: GntR; COG1802 62977002267 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 62977002268 DNA-binding site [nucleotide binding]; DNA binding site 62977002269 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 62977002270 AAA domain; Region: AAA_23; pfam13476 62977002271 Walker A/P-loop; other site 62977002272 ATP binding site [chemical binding]; other site 62977002273 Q-loop/lid; other site 62977002274 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 62977002275 ABC transporter signature motif; other site 62977002276 Walker B; other site 62977002277 D-loop; other site 62977002278 H-loop/switch region; other site 62977002279 Cell division protein [Cell division and chromosome partitioning]; Region: ZipA; COG3115 62977002280 ZipA, C-terminal FtsZ-binding domain; Region: ZipA_C; pfam04354 62977002281 FtsZ protein binding site [polypeptide binding]; other site 62977002282 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 62977002283 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 62977002284 nucleotide binding pocket [chemical binding]; other site 62977002285 K-X-D-G motif; other site 62977002286 catalytic site [active] 62977002287 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 62977002288 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 62977002289 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 62977002290 Dimer interface [polypeptide binding]; other site 62977002291 BRCT sequence motif; other site 62977002292 hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466 62977002293 aldehyde reductase, extended (e) SDRs; Region: AR_SDR_e; cd05227 62977002294 NADP binding site [chemical binding]; other site 62977002295 putative substrate binding site [chemical binding]; other site 62977002296 active site 62977002297 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 62977002298 Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193 62977002299 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 62977002300 heme binding site [chemical binding]; other site 62977002301 ferroxidase pore; other site 62977002302 ferroxidase diiron center [ion binding]; other site 62977002303 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 62977002304 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 62977002305 catalytic triad [active] 62977002306 pimelyl-[acyl-carrier protein] methyl ester esterase; Region: bioH; TIGR01738 62977002307 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 62977002308 adenosylmethionine-8-amino-7-oxononanoate transaminase; Region: bioA; TIGR00508 62977002309 inhibitor-cofactor binding pocket; inhibition site 62977002310 pyridoxal 5'-phosphate binding site [chemical binding]; other site 62977002311 catalytic residue [active] 62977002312 8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958 62977002313 Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155 62977002314 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 62977002315 catalytic residue [active] 62977002316 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 62977002317 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 62977002318 S-adenosylmethionine binding site [chemical binding]; other site 62977002319 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 62977002320 AAA domain; Region: AAA_26; pfam13500 62977002321 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 62977002322 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 62977002323 RNA binding surface [nucleotide binding]; other site 62977002324 Pseudouridine synthase, Escherichia coli RluB like; Region: PseudoU_synth_RluB; cd02556 62977002325 probable active site [active] 62977002326 Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079 62977002327 ScpA/B protein; Region: ScpA_ScpB; cl00598 62977002328 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 62977002329 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 62977002330 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 62977002331 Protein of unknown function, DUF462; Region: DUF462; pfam04315 62977002332 Uncharacterized ACR, COG1399; Region: DUF177; cl00616 62977002333 50S ribosomal protein L32; Validated; Region: rpmF; PRK01110 62977002334 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 62977002335 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 62977002336 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 62977002337 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 62977002338 NAD(P) binding site [chemical binding]; other site 62977002339 homotetramer interface [polypeptide binding]; other site 62977002340 homodimer interface [polypeptide binding]; other site 62977002341 active site 62977002342 acyl carrier protein; Provisional; Region: acpP; PRK00982 62977002343 LysM domain/BON superfamily protein; Provisional; Region: PRK11198 62977002344 BON domain; Region: BON; pfam04972 62977002345 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 62977002346 Restriction endonuclease; Region: Mrr_cat; pfam04471 62977002347 Domain of unknown function (DUF955); Region: DUF955; cl01076 62977002348 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 62977002349 dimer interface [polypeptide binding]; other site 62977002350 substrate binding site [chemical binding]; other site 62977002351 ATP binding site [chemical binding]; other site 62977002352 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 62977002353 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 62977002354 motif II; other site 62977002355 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 62977002356 Uncharacterized protein family (UPF0093); Region: UPF0093; pfam03653 62977002357 3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK07967 62977002358 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 62977002359 dimer interface [polypeptide binding]; other site 62977002360 active site 62977002361 EcsC protein family; Region: EcsC; pfam12787 62977002362 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 62977002363 S17 interaction site [polypeptide binding]; other site 62977002364 S8 interaction site; other site 62977002365 16S rRNA interaction site [nucleotide binding]; other site 62977002366 streptomycin interaction site [chemical binding]; other site 62977002367 23S rRNA interaction site [nucleotide binding]; other site 62977002368 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 62977002369 30S ribosomal protein S7; Validated; Region: PRK05302 62977002370 elongation factor G; Reviewed; Region: PRK00007 62977002371 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 62977002372 G1 box; other site 62977002373 putative GEF interaction site [polypeptide binding]; other site 62977002374 GTP/Mg2+ binding site [chemical binding]; other site 62977002375 Switch I region; other site 62977002376 G2 box; other site 62977002377 G3 box; other site 62977002378 Switch II region; other site 62977002379 G4 box; other site 62977002380 G5 box; other site 62977002381 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 62977002382 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 62977002383 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 62977002384 elongation factor Tu; Reviewed; Region: PRK00049 62977002385 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 62977002386 G1 box; other site 62977002387 GEF interaction site [polypeptide binding]; other site 62977002388 GTP/Mg2+ binding site [chemical binding]; other site 62977002389 Switch I region; other site 62977002390 G2 box; other site 62977002391 G3 box; other site 62977002392 Switch II region; other site 62977002393 G4 box; other site 62977002394 G5 box; other site 62977002395 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 62977002396 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 62977002397 Antibiotic Binding Site [chemical binding]; other site 62977002398 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687 62977002399 Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118 62977002400 ribosomal-protein-alanine N-acetyltransferase; Provisional; Region: rimI; PRK09491 62977002401 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 62977002402 Coenzyme A binding pocket [chemical binding]; other site 62977002403 GNAT acetyltransferase 2; Region: GNAT_acetyltr_2; pfam13718 62977002404 arginyl-tRNA-protein transferase; Provisional; Region: PRK01305 62977002405 Arginine-tRNA-protein transferase, N terminus; Region: ATE_N; pfam04376 62977002406 Arginine-tRNA-protein transferase, C terminus; Region: ATE_C; pfam04377 62977002407 leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301 62977002408 thioredoxin reductase; Provisional; Region: PRK10262 62977002409 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 62977002410 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 62977002411 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 62977002412 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 62977002413 This domain directs oriented DNA translocation and forms a winged helix structure; Region: Ftsk_gamma; smart00843 62977002414 Septum formation topological specificity factor MinE; Region: MinE; pfam03776 62977002415 Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894 62977002416 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 62977002417 Switch I; other site 62977002418 Switch II; other site 62977002419 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 62977002420 Septum formation inhibitor [Cell division and chromosome partitioning]; Region: MinC; COG0850 62977002421 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 62977002422 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; Region: LPLAT_LCLAT1-like; cd07990 62977002423 putative acyl-acceptor binding pocket; other site 62977002424 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 62977002425 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 62977002426 ligand binding site [chemical binding]; other site 62977002427 ATP-dependent DNA helicase Rep; Region: rep; TIGR01074 62977002428 Part of AAA domain; Region: AAA_19; pfam13245 62977002429 Family description; Region: UvrD_C_2; pfam13538 62977002430 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 62977002431 trimer interface [polypeptide binding]; other site 62977002432 active site 62977002433 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 62977002434 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 62977002435 active site 62977002436 substrate binding site [chemical binding]; other site 62977002437 metal binding site [ion binding]; metal-binding site 62977002438 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 62977002439 feedback inhibition sensing region; other site 62977002440 homohexameric interface [polypeptide binding]; other site 62977002441 nucleotide binding site [chemical binding]; other site 62977002442 N-acetyl-L-glutamate binding site [chemical binding]; other site 62977002443 Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; pfam13444 62977002444 Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121 62977002445 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 62977002446 putative active site [active] 62977002447 putative dimer interface [polypeptide binding]; other site 62977002448 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 62977002449 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 62977002450 hypothetical protein; Validated; Region: PRK01777 62977002451 SmpA / OmlA family; Region: SmpA_OmlA; cl17115 62977002452 outer membrane biogenesis protein BamE; Provisional; Region: PRK11548 62977002453 SmpA / OmlA family; Region: SmpA_OmlA; pfam04355 62977002454 ferric uptake regulator; Provisional; Region: fur; PRK09462 62977002455 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 62977002456 metal binding site 2 [ion binding]; metal-binding site 62977002457 putative DNA binding helix; other site 62977002458 metal binding site 1 [ion binding]; metal-binding site 62977002459 dimer interface [polypeptide binding]; other site 62977002460 structural Zn2+ binding site [ion binding]; other site 62977002461 Tfp pilus assembly protein, ATPase PilU [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilU; COG5008 62977002462 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 62977002463 Walker A motif; other site 62977002464 ATP binding site [chemical binding]; other site 62977002465 Walker B motif; other site 62977002466 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 62977002467 Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131 62977002468 Walker A motif; other site 62977002469 ATP binding site [chemical binding]; other site 62977002470 Walker B motif; other site 62977002471 Pyridoxal 5-phosphate (PLP)-binding TIM barrel domain of Type III PLP-Dependent Enzymes, Yggs-like proteins; Region: PLPDE_III_Yggs_like; cd06824 62977002472 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 62977002473 catalytic residue [active] 62977002474 Bacitracin resistance protein BacA; Region: BacA; pfam02673 62977002475 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 62977002476 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 62977002477 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 62977002478 AAA domain; Region: AAA_23; pfam13476 62977002479 Walker A/P-loop; other site 62977002480 ATP binding site [chemical binding]; other site 62977002481 Q-loop/lid; other site 62977002482 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 62977002483 ABC transporter signature motif; other site 62977002484 Walker B; other site 62977002485 D-loop; other site 62977002486 H-loop/switch region; other site 62977002487 exonuclease subunit SbcD; Provisional; Region: PRK10966 62977002488 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 62977002489 active site 62977002490 metal binding site [ion binding]; metal-binding site 62977002491 DNA binding site [nucleotide binding] 62977002492 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 62977002493 OsmC-like protein; Region: OsmC; cl00767 62977002494 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 62977002495 TIGR01777 family protein; Region: yfcH 62977002496 NAD(P) binding site [chemical binding]; other site 62977002497 active site 62977002498 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 62977002499 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 62977002500 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823 62977002501 dimer interface [polypeptide binding]; other site 62977002502 allosteric magnesium binding site [ion binding]; other site 62977002503 active site 62977002504 aspartate-rich active site metal binding site; other site 62977002505 Schiff base residues; other site 62977002506 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 62977002507 CoenzymeA binding site [chemical binding]; other site 62977002508 subunit interaction site [polypeptide binding]; other site 62977002509 PHB binding site; other site 62977002510 efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998 62977002511 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 62977002512 HlyD family secretion protein; Region: HlyD_3; pfam13437 62977002513 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 62977002514 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 62977002515 putative substrate translocation pore; other site 62977002516 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 62977002517 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 62977002518 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 62977002519 glycerol kinase; Provisional; Region: glpK; PRK00047 62977002520 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 62977002521 N- and C-terminal domain interface [polypeptide binding]; other site 62977002522 active site 62977002523 MgATP binding site [chemical binding]; other site 62977002524 catalytic site [active] 62977002525 metal binding site [ion binding]; metal-binding site 62977002526 glycerol binding site [chemical binding]; other site 62977002527 homotetramer interface [polypeptide binding]; other site 62977002528 homodimer interface [polypeptide binding]; other site 62977002529 FBP binding site [chemical binding]; other site 62977002530 protein IIAGlc interface [polypeptide binding]; other site 62977002531 DoxX; Region: DoxX; pfam07681 62977002532 hypothetical protein; Provisional; Region: PRK05409 62977002533 Uncharacterized protein conserved in bacteria (DUF2063); Region: DUF2063; cl01262 62977002534 RNA polymerase sigma factor; Provisional; Region: PRK12544 62977002535 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 62977002536 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 62977002537 DNA binding residues [nucleotide binding] 62977002538 Putative zinc-finger; Region: zf-HC2; pfam13490 62977002539 Protein of unknown function (DUF805); Region: DUF805; pfam05656 62977002540 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 62977002541 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 62977002542 Haemolysin secretion/activation protein ShlB/FhaC/HecB; Region: ShlB; pfam03865 62977002543 haemagglutination activity domain; Region: Haemagg_act; pfam05860 62977002544 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 62977002545 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 62977002546 Bacterial EndoU nuclease; Region: EndoU_bacteria; pfam14436 62977002547 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 62977002548 putative transposase OrfB; Reviewed; Region: PHA02517 62977002549 HTH-like domain; Region: HTH_21; pfam13276 62977002550 Integrase core domain; Region: rve; pfam00665 62977002551 Integrase core domain; Region: rve_2; pfam13333 62977002552 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 62977002553 Transposase; Region: HTH_Tnp_1; pfam01527 62977002554 putative transposase OrfB; Reviewed; Region: PHA02517 62977002555 HTH-like domain; Region: HTH_21; pfam13276 62977002556 Integrase core domain; Region: rve; pfam00665 62977002557 Integrase core domain; Region: rve_2; pfam13333 62977002558 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 62977002559 Transposase; Region: HTH_Tnp_1; pfam01527 62977002560 Protein of unknown function (DUF3792); Region: DUF3792; pfam12670 62977002561 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 62977002562 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 62977002563 NAD(P) binding site [chemical binding]; other site 62977002564 catalytic residues [active] 62977002565 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 62977002566 nudix motif; other site 62977002567 Uncharacterized conserved protein [General function prediction only]; Region: COG4111 62977002568 putative nicotinate phosphoribosyltransferase; Provisional; Region: PRK09198 62977002569 pre-B-cell colony-enhancing factor (PBEF)-like. The mammalian members of this group of nicotinate phosphoribosyltransferases (NAPRTases) were originally identified as genes whose expression is upregulated upon activation in lymphoid cells. In general; Region: PBEF_like; cd01569 62977002570 active site 62977002571 Phosphoribosylpyrophosphate synthetase [Nucleotide transport and metabolism / Amino acid transport and metabolism]; Region: PrsA; COG0462 62977002572 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 62977002573 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 62977002574 active site 62977002575 PAP2, bacterial acid phosphatase or class A non-specific acid phosphatases. These enzymes catalyze phosphomonoester hydrolysis, with optimal activity in low pH conditions. They are secreted into the periplasmic space, and their physiological role remains...; Region: PAP2_acid_phosphatase; cd03397 62977002576 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 62977002577 active site 62977002578 Lysine efflux permease [General function prediction only]; Region: COG1279 62977002579 transcriptional regulator, ArgP family; Region: argP; TIGR03298 62977002580 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 62977002581 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 62977002582 dimerization interface [polypeptide binding]; other site 62977002583 Transcriptional regulators [Transcription]; Region: GntR; COG1802 62977002584 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 62977002585 DNA-binding site [nucleotide binding]; DNA binding site 62977002586 FCD domain; Region: FCD; pfam07729 62977002587 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 62977002588 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 62977002589 Walker A/P-loop; other site 62977002590 ATP binding site [chemical binding]; other site 62977002591 Q-loop/lid; other site 62977002592 ABC transporter signature motif; other site 62977002593 Walker B; other site 62977002594 D-loop; other site 62977002595 H-loop/switch region; other site 62977002596 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 62977002597 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 62977002598 ABC-ATPase subunit interface; other site 62977002599 dimer interface [polypeptide binding]; other site 62977002600 putative PBP binding regions; other site 62977002601 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 62977002602 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 62977002603 intersubunit interface [polypeptide binding]; other site 62977002604 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 62977002605 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 62977002606 N-terminal plug; other site 62977002607 ligand-binding site [chemical binding]; other site 62977002608 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 62977002609 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 62977002610 Coenzyme A binding pocket [chemical binding]; other site 62977002611 Isopenicillin N synthase and related dioxygenases [General function prediction only]; Region: PcbC; COG3491 62977002612 non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226 62977002613 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171 62977002614 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 62977002615 Transcriptional regulators [Transcription]; Region: FadR; COG2186 62977002616 DNA-binding site [nucleotide binding]; DNA binding site 62977002617 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 62977002618 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 62977002619 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 62977002620 FMN-binding pocket [chemical binding]; other site 62977002621 flavin binding motif; other site 62977002622 phosphate binding motif [ion binding]; other site 62977002623 beta-alpha-beta structure motif; other site 62977002624 NAD binding pocket [chemical binding]; other site 62977002625 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 62977002626 catalytic loop [active] 62977002627 iron binding site [ion binding]; other site 62977002628 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 62977002629 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 62977002630 iron-sulfur cluster [ion binding]; other site 62977002631 [2Fe-2S] cluster binding site [ion binding]; other site 62977002632 C-terminal catalytic domain of the oxygenase alpha subunit of dicamba O-demethylase and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_DMO-like; cd08878 62977002633 alpha subunit interface [polypeptide binding]; other site 62977002634 active site 62977002635 substrate binding site [chemical binding]; other site 62977002636 Fe binding site [ion binding]; other site 62977002637 benzoate transport; Region: 2A0115; TIGR00895 62977002638 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 62977002639 putative substrate translocation pore; other site 62977002640 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 62977002641 outer membrane porin, OprD family; Region: OprD; pfam03573 62977002642 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 62977002643 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 62977002644 Transcriptional regulator [Transcription]; Region: IclR; COG1414 62977002645 Bacterial transcriptional regulator; Region: IclR; pfam01614 62977002646 Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528 62977002647 [2Fe-2S] cluster binding site [ion binding]; other site 62977002648 Herpes virus intermediate/early protein 2/3; Region: Herpes_IE2_3; pfam03361 62977002649 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 62977002650 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 62977002651 [2Fe-2S] cluster binding site [ion binding]; other site 62977002652 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 62977002653 hydrophobic ligand binding site; other site 62977002654 short chain dehydrogenase; Provisional; Region: PRK12939 62977002655 classical (c) SDRs; Region: SDR_c; cd05233 62977002656 NAD(P) binding site [chemical binding]; other site 62977002657 active site 62977002658 C-terminal domain of Burkholderia sp. NF100 MhqB and similar proteins; MhqB is a type I extradiol dioxygenase involved in the catabolism of methylhydroquinone, an intermediate in the degradation of fenitrothion; Region: MhqB_like_C; cd08360 62977002659 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 62977002660 putative active site [active] 62977002661 putative metal binding site [ion binding]; other site 62977002662 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 62977002663 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 62977002664 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 62977002665 D-galactonate transporter; Region: 2A0114; TIGR00893 62977002666 putative substrate translocation pore; other site 62977002667 Cupin domain; Region: Cupin_2; pfam07883 62977002668 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 62977002669 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 62977002670 short chain dehydrogenase; Provisional; Region: PRK07062 62977002671 putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344 62977002672 putative NAD(P) binding site [chemical binding]; other site 62977002673 putative active site [active] 62977002674 L-aspartate dehydrogenase; Provisional; Region: PRK13303 62977002675 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 62977002676 Domain of unknown function DUF108; Region: DUF108; pfam01958 62977002677 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 62977002678 Uncharacterized Candidatus pelagibacter aldehyde dehydrogenase, DhaS-like; Region: ALDH_DhaS; cd07114 62977002679 NAD(P) binding site [chemical binding]; other site 62977002680 catalytic residues [active] 62977002681 hypothetical protein; Provisional; Region: PRK07064 62977002682 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 62977002683 PYR/PP interface [polypeptide binding]; other site 62977002684 dimer interface [polypeptide binding]; other site 62977002685 TPP binding site [chemical binding]; other site 62977002686 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 62977002687 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 62977002688 TPP-binding site [chemical binding]; other site 62977002689 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 62977002690 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 62977002691 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 62977002692 Coenzyme A binding pocket [chemical binding]; other site 62977002693 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 62977002694 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 62977002695 N-terminal plug; other site 62977002696 ligand-binding site [chemical binding]; other site 62977002697 Predicted membrane protein [Function unknown]; Region: COG3503 62977002698 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 62977002699 H+ Antiporter protein; Region: 2A0121; TIGR00900 62977002700 putative substrate translocation pore; other site 62977002701 malate:quinone oxidoreductase; Validated; Region: PRK05257 62977002702 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 62977002703 choline dehydrogenase; Validated; Region: PRK02106 62977002704 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 62977002705 betaine aldehyde dehydrogenase; Provisional; Region: PRK13252 62977002706 NAD+-dependent 4-trimethylaminobutyraldehyde dehydrogenase, ALDH family 9A1; Region: ALDH_F9_TMBADH; cd07090 62977002707 tetrameric interface [polypeptide binding]; other site 62977002708 NAD binding site [chemical binding]; other site 62977002709 catalytic residues [active] 62977002710 transcriptional regulator BetI; Validated; Region: PRK00767 62977002711 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 62977002712 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 62977002713 BCCT family transporter; Region: BCCT; pfam02028 62977002714 choline transport protein BetT; Provisional; Region: PRK09928 62977002715 Multiple antibiotic transporter [Intracellular trafficking and secretion]; Region: MarC; COG2095 62977002716 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 62977002717 lipoyl synthase; Provisional; Region: PRK05481 62977002718 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 62977002719 FeS/SAM binding site; other site 62977002720 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182 62977002721 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 62977002722 tetramer interface [polypeptide binding]; other site 62977002723 TPP-binding site [chemical binding]; other site 62977002724 heterodimer interface [polypeptide binding]; other site 62977002725 phosphorylation loop region [posttranslational modification] 62977002726 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 62977002727 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 62977002728 alpha subunit interface [polypeptide binding]; other site 62977002729 TPP binding site [chemical binding]; other site 62977002730 heterodimer interface [polypeptide binding]; other site 62977002731 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 62977002732 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 62977002733 pyruvate dehydrogenase complex dihydrolipoamide acetyltransferase, long form; Region: PDHac_trf_mito; TIGR01349 62977002734 E3 interaction surface; other site 62977002735 lipoyl attachment site [posttranslational modification]; other site 62977002736 e3 binding domain; Region: E3_binding; pfam02817 62977002737 e3 binding domain; Region: E3_binding; pfam02817 62977002738 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 62977002739 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 62977002740 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 62977002741 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 62977002742 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 62977002743 (2R,3R)-2,3-butanediol dehydrogenase; Region: butanediol_DH_like; cd08233 62977002744 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 62977002745 putative NAD(P) binding site [chemical binding]; other site 62977002746 catalytic Zn binding site [ion binding]; other site 62977002747 acetoin reductases; Region: 23BDH; TIGR02415 62977002748 meso-2,3-butanediol dehydrogenase-like, classical (c) SDRs; Region: meso-BDH-like_SDR_c; cd05366 62977002749 NAD binding site [chemical binding]; other site 62977002750 homotetramer interface [polypeptide binding]; other site 62977002751 homodimer interface [polypeptide binding]; other site 62977002752 active site 62977002753 substrate binding site [chemical binding]; other site 62977002754 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 62977002755 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 62977002756 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 62977002757 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 62977002758 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 62977002759 YaeQ protein; Region: YaeQ; pfam07152 62977002760 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 62977002761 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 62977002762 poly-beta-1,6-N-acetyl-D-glucosamine N-deacetylase PgaB; Region: deacetyl_PgaB; TIGR03938 62977002763 N-terminal putative catalytic polysaccharide deacetylase domain of bacterial poly-beta-1,6-N-acetyl-D-glucosamine N-deacetylase PgaB, and similar proteins; Region: CE4_PgaB_5s; cd10964 62977002764 putative active site [active] 62977002765 putative metal binding site [ion binding]; other site 62977002766 N-glycosyltransferase; Provisional; Region: PRK11204 62977002767 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 62977002768 DXD motif; other site 62977002769 poly-beta-1,6-N-acetyl-D-glucosamine biosynthesis protein PgaD; Region: PGA_PgaD; TIGR03940 62977002770 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 62977002771 Nicotinamide mononucleotide transporter; Region: NMN_transporter; pfam04973 62977002772 Phospholipase/Carboxylesterase; Region: Abhydrolase_2; pfam02230 62977002773 putative hydrolase; Provisional; Region: PRK11460 62977002774 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 62977002775 metabolite-proton symporter; Region: 2A0106; TIGR00883 62977002776 putative substrate translocation pore; other site 62977002777 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 62977002778 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 62977002779 active site 62977002780 motif I; other site 62977002781 motif II; other site 62977002782 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 62977002783 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 62977002784 active site 62977002785 catalytic residues [active] 62977002786 metal binding site [ion binding]; metal-binding site 62977002787 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 62977002788 glutaminase; Provisional; Region: PRK00971 62977002789 Helix-turn-helix domain; Region: HTH_18; pfam12833 62977002790 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 62977002791 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 62977002792 putative substrate translocation pore; other site 62977002793 Major Facilitator Superfamily; Region: MFS_1; pfam07690 62977002794 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 62977002795 DNA-binding site [nucleotide binding]; DNA binding site 62977002796 RNA-binding motif; other site 62977002797 B12-dependent methionine synthase; Provisional; Region: metH; PRK09490 62977002798 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 62977002799 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 62977002800 substrate binding pocket [chemical binding]; other site 62977002801 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 62977002802 B12 binding site [chemical binding]; other site 62977002803 cobalt ligand [ion binding]; other site 62977002804 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 62977002805 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 62977002806 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 62977002807 D-Serine dehydratase is a pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of L- or D-serine to pyruvate and ammonia. D-serine dehydratase serves as a detoxifying enzyme in most E. coli strains where D-serine is a competitive...; Region: D-Ser-dehyd; cd06447 62977002808 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 62977002809 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 62977002810 catalytic residue [active] 62977002811 Rhomboid family; Region: Rhomboid; cl11446 62977002812 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 62977002813 IscR-regulated protein YhgI; Region: YhgI_GntY; TIGR03341 62977002814 Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694 62977002815 outer membrane receptor FepA; Provisional; Region: PRK13524 62977002816 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 62977002817 N-terminal plug; other site 62977002818 ligand-binding site [chemical binding]; other site 62977002819 Outer membrane receptor for ferrienterochelin and colicins [Inorganic ion transport and metabolism]; Region: FepA; COG4771 62977002820 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 62977002821 N-terminal plug; other site 62977002822 ligand-binding site [chemical binding]; other site 62977002823 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378 62977002824 active site clefts [active] 62977002825 zinc binding site [ion binding]; other site 62977002826 dimer interface [polypeptide binding]; other site 62977002827 Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822 62977002828 active site 62977002829 catalytic triad [active] 62977002830 oxyanion hole [active] 62977002831 switch loop; other site 62977002832 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 62977002833 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 62977002834 Walker A/P-loop; other site 62977002835 ATP binding site [chemical binding]; other site 62977002836 Q-loop/lid; other site 62977002837 ABC transporter signature motif; other site 62977002838 Walker B; other site 62977002839 D-loop; other site 62977002840 H-loop/switch region; other site 62977002841 FtsX-like permease family; Region: FtsX; pfam02687 62977002842 FtsX-like permease family; Region: FtsX; pfam02687 62977002843 Rhomboid family; Region: Rhomboid; pfam01694 62977002844 monofunctional biosynthetic peptidoglycan transglycosylase; Provisional; Region: mtgA; PRK00056 62977002845 monofunctional biosynthetic peptidoglycan transglycosylase; Region: mono_pep_trsgly; TIGR02070 62977002846 polyphosphate kinase; Provisional; Region: PRK05443 62977002847 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 62977002848 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 62977002849 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 62977002850 putative active site [active] 62977002851 catalytic site [active] 62977002852 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 62977002853 putative active site [active] 62977002854 putative domain interface [polypeptide binding]; other site 62977002855 catalytic site [active] 62977002856 DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151 62977002857 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 62977002858 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 62977002859 dimerization interface [polypeptide binding]; other site 62977002860 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 62977002861 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 62977002862 NADH:flavorubredoxin oxidoreductase; Provisional; Region: PRK04965 62977002863 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 62977002864 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 62977002865 Rubredoxin [Energy production and conversion]; Region: COG1773 62977002866 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 62977002867 iron binding site [ion binding]; other site 62977002868 Uncharacterized protein family (UPF0227); Region: UPF0227; cl14886 62977002869 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 62977002870 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 62977002871 dimer interface [polypeptide binding]; other site 62977002872 putative anticodon binding site; other site 62977002873 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 62977002874 motif 1; other site 62977002875 active site 62977002876 motif 2; other site 62977002877 motif 3; other site 62977002878 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 62977002879 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 62977002880 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 62977002881 cobyric acid synthase; Provisional; Region: PRK00784 62977002882 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 62977002883 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 62977002884 catalytic triad [active] 62977002885 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 62977002886 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 62977002887 Active Sites [active] 62977002888 sulfate adenylyltransferase subunit 1; Provisional; Region: cysN; PRK05124 62977002889 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 62977002890 CysD dimerization site [polypeptide binding]; other site 62977002891 G1 box; other site 62977002892 putative GEF interaction site [polypeptide binding]; other site 62977002893 GTP/Mg2+ binding site [chemical binding]; other site 62977002894 Switch I region; other site 62977002895 G2 box; other site 62977002896 G3 box; other site 62977002897 Switch II region; other site 62977002898 G4 box; other site 62977002899 G5 box; other site 62977002900 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 62977002901 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 62977002902 H+/citrate symporter [Energy production and conversion]; Region: CitM; COG2851 62977002903 Citrate transporter; Region: CitMHS; pfam03600 62977002904 Domain of unknown function (DUF1989); Region: DUF1989; cl01474 62977002905 Domain of unknown function (DUF1989); Region: DUF1989; cl01474 62977002906 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 62977002907 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 62977002908 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 62977002909 Domain of unknown function DUF21; Region: DUF21; pfam01595 62977002910 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 62977002911 Transporter associated domain; Region: CorC_HlyC; smart01091 62977002912 Transcriptional regulator [Transcription]; Region: LysR; COG0583 62977002913 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 62977002914 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 62977002915 substrate binding pocket [chemical binding]; other site 62977002916 dimerization interface [polypeptide binding]; other site 62977002917 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 62977002918 tetramer interface [polypeptide binding]; other site 62977002919 active site 62977002920 Mg2+/Mn2+ binding site [ion binding]; other site 62977002921 isocitrate lyase; Region: PLN02892 62977002922 NlpE N-terminal domain; Region: NlpE; pfam04170 62977002923 UreD urease accessory protein; Region: UreD; pfam01774 62977002924 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 62977002925 alpha-gamma subunit interface [polypeptide binding]; other site 62977002926 beta-gamma subunit interface [polypeptide binding]; other site 62977002927 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 62977002928 gamma-beta subunit interface [polypeptide binding]; other site 62977002929 alpha-beta subunit interface [polypeptide binding]; other site 62977002930 urease subunit alpha; Reviewed; Region: ureC; PRK13207 62977002931 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 62977002932 subunit interactions [polypeptide binding]; other site 62977002933 active site 62977002934 flap region; other site 62977002935 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 62977002936 catalytic core [active] 62977002937 urease accessory protein UreE; Provisional; Region: ureE; PRK13261 62977002938 UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571 62977002939 dimer interface [polypeptide binding]; other site 62977002940 catalytic residues [active] 62977002941 Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830 62977002942 UreF; Region: UreF; pfam01730 62977002943 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 62977002944 HupE / UreJ protein; Region: HupE_UreJ; pfam04955 62977002945 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 62977002946 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 62977002947 S-adenosylmethionine binding site [chemical binding]; other site 62977002948 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 62977002949 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 62977002950 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 62977002951 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399 62977002952 adenylate kinase; Reviewed; Region: adk; PRK00279 62977002953 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 62977002954 AMP-binding site [chemical binding]; other site 62977002955 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 62977002956 endonuclease III; Provisional; Region: PRK10702 62977002957 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 62977002958 minor groove reading motif; other site 62977002959 helix-hairpin-helix signature motif; other site 62977002960 substrate binding pocket [chemical binding]; other site 62977002961 active site 62977002962 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 62977002963 Putative Fe-S cluster; Region: FeS; cl17515 62977002964 Ferredoxin [Energy production and conversion]; Region: COG1146 62977002965 4Fe-4S binding domain; Region: Fer4; pfam00037 62977002966 glutamate dehydrogenase; Provisional; Region: PRK09414 62977002967 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 62977002968 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 62977002969 NAD(P) binding site [chemical binding]; other site 62977002970 META domain; Region: META; pfam03724 62977002971 Domain of unknown function (DUF4377); Region: DUF4377; pfam14302 62977002972 The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363 62977002973 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 62977002974 putative active site [active] 62977002975 metal binding site [ion binding]; metal-binding site 62977002976 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 62977002977 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 62977002978 Found in ATP-dependent protease La (LON); Region: LON; smart00464 62977002979 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 62977002980 Walker A motif; other site 62977002981 ATP binding site [chemical binding]; other site 62977002982 Walker B motif; other site 62977002983 arginine finger; other site 62977002984 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 62977002985 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 62977002986 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 62977002987 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 62977002988 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 62977002989 Predicted membrane protein [Function unknown]; Region: COG2246 62977002990 GtrA-like protein; Region: GtrA; pfam04138 62977002991 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 62977002992 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 62977002993 Ligand binding site; other site 62977002994 Putative Catalytic site; other site 62977002995 DXD motif; other site 62977002996 uncharacterized YdjC-like family proteins from bacteria; Region: YdjC_like_3; cd10807 62977002997 putative active site [active] 62977002998 YdjC motif; other site 62977002999 Mg binding site [ion binding]; other site 62977003000 putative homodimer interface [polypeptide binding]; other site 62977003001 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 62977003002 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 62977003003 nucleophilic elbow; other site 62977003004 catalytic triad; other site 62977003005 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 62977003006 Cell division protein ZapA; Region: ZapA; cl01146 62977003007 integrating conjugative element protein, PFL_4705 family; Region: conj_TIGR03752 62977003008 Uncharacterized protein family (UPF0149); Region: UPF0149; pfam03695 62977003009 proline aminopeptidase P II; Provisional; Region: PRK10879 62977003010 Aminopeptidase P, N-terminal domain; Region: AMP_N; pfam05195 62977003011 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 62977003012 active site 62977003013 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 62977003014 Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988 62977003015 Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988 62977003016 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 62977003017 Predicted methyltransferases [General function prediction only]; Region: COG0313 62977003018 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 62977003019 putative SAM binding site [chemical binding]; other site 62977003020 putative homodimer interface [polypeptide binding]; other site 62977003021 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 62977003022 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 62977003023 hypothetical protein; Provisional; Region: PRK14674 62977003024 Predicted periplasmic or secreted lipoprotein [General function prediction only]; Region: OsmY; COG2823 62977003025 BON domain; Region: BON; pfam04972 62977003026 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 62977003027 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 62977003028 substrate binding pocket [chemical binding]; other site 62977003029 NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296 62977003030 NADH pyrophosphatase; Reviewed; Region: nudC; PRK00241 62977003031 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 62977003032 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 62977003033 putative NADH binding site [chemical binding]; other site 62977003034 putative active site [active] 62977003035 nudix motif; other site 62977003036 putative metal binding site [ion binding]; other site 62977003037 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 62977003038 RNA/DNA hybrid binding site [nucleotide binding]; other site 62977003039 active site 62977003040 DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406 62977003041 DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131 62977003042 active site 62977003043 catalytic site [active] 62977003044 substrate binding site [chemical binding]; other site 62977003045 membrane-bound lytic murein transglycosylase D; Provisional; Region: mltD; PRK10783 62977003046 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 62977003047 N-acetyl-D-glucosamine binding site [chemical binding]; other site 62977003048 catalytic residue [active] 62977003049 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 62977003050 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 62977003051 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 62977003052 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 62977003053 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 62977003054 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 62977003055 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 62977003056 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 62977003057 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 62977003058 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 62977003059 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497 62977003060 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4174 62977003061 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 62977003062 dimer interface [polypeptide binding]; other site 62977003063 conserved gate region; other site 62977003064 ABC-ATPase subunit interface; other site 62977003065 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4239 62977003066 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 62977003067 dimer interface [polypeptide binding]; other site 62977003068 conserved gate region; other site 62977003069 putative PBP binding loops; other site 62977003070 ABC-ATPase subunit interface; other site 62977003071 ABC-type uncharacterized transport system, duplicated ATPase component [General function prediction only]; Region: COG4172 62977003072 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 62977003073 Walker A/P-loop; other site 62977003074 ATP binding site [chemical binding]; other site 62977003075 Q-loop/lid; other site 62977003076 ABC transporter signature motif; other site 62977003077 Walker B; other site 62977003078 D-loop; other site 62977003079 H-loop/switch region; other site 62977003080 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 62977003081 Walker A/P-loop; other site 62977003082 ATP binding site [chemical binding]; other site 62977003083 Q-loop/lid; other site 62977003084 ABC transporter signature motif; other site 62977003085 Walker B; other site 62977003086 D-loop; other site 62977003087 H-loop/switch region; other site 62977003088 Old yellow enzyme (OYE)-related FMN binding domain, group 2. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_2_FMN; cd04733 62977003089 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 62977003090 putative active site [active] 62977003091 putative FMN binding site [chemical binding]; other site 62977003092 putative substrate binding site [chemical binding]; other site 62977003093 putative catalytic residue [active] 62977003094 S-methylmethionine transporter; Provisional; Region: PRK11387 62977003095 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 62977003096 DEDDh 3'-5' exonuclease domain of RNase T; Region: RNaseT; cd06134 62977003097 dimer interface [polypeptide binding]; other site 62977003098 catalytic site [active] 62977003099 putative active site [active] 62977003100 putative substrate binding site [chemical binding]; other site 62977003101 Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294 62977003102 active site 62977003103 substrate binding pocket [chemical binding]; other site 62977003104 dimer interface [polypeptide binding]; other site 62977003105 argininosuccinate synthase; Provisional; Region: PRK13820 62977003106 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 62977003107 ANP binding site [chemical binding]; other site 62977003108 Substrate Binding Site II [chemical binding]; other site 62977003109 Substrate Binding Site I [chemical binding]; other site 62977003110 Transcriptional regulator [Transcription]; Region: LysR; COG0583 62977003111 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 62977003112 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 62977003113 dimerization interface [polypeptide binding]; other site 62977003114 EamA-like transporter family; Region: EamA; pfam00892 62977003115 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 62977003116 EamA-like transporter family; Region: EamA; pfam00892 62977003117 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 62977003118 2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930 62977003119 active site 62977003120 FMN binding site [chemical binding]; other site 62977003121 2,4-decadienoyl-CoA binding site; other site 62977003122 catalytic residue [active] 62977003123 4Fe-4S cluster binding site [ion binding]; other site 62977003124 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 62977003125 multidrug efflux system subunit MdtA; Provisional; Region: PRK11556 62977003126 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 62977003127 HlyD family secretion protein; Region: HlyD_3; pfam13437 62977003128 multidrug efflux system subunit MdtB; Provisional; Region: PRK10503 62977003129 Protein export membrane protein; Region: SecD_SecF; cl14618 62977003130 multidrug efflux system subunit MdtC; Provisional; Region: PRK10614 62977003131 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 62977003132 RNA polymerase sigma factor; Provisional; Region: PRK12528 62977003133 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 62977003134 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 62977003135 DNA binding residues [nucleotide binding] 62977003136 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 62977003137 FecR protein; Region: FecR; pfam04773 62977003138 Secretin and TonB N terminus short domain; Region: STN; smart00965 62977003139 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 62977003140 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 62977003141 N-terminal plug; other site 62977003142 ligand-binding site [chemical binding]; other site 62977003143 chaperone protein HchA; Provisional; Region: PRK04155 62977003144 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 62977003145 conserved cys residue [active] 62977003146 LuxR family transcriptional regulatory, chaperone HchA-associated; Region: reg_near_HchA; TIGR03541 62977003147 Autoinducer binding domain; Region: Autoind_bind; pfam03472 62977003148 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 62977003149 DNA binding residues [nucleotide binding] 62977003150 dimerization interface [polypeptide binding]; other site 62977003151 Urocanate hydratase [Amino acid transport and metabolism]; Region: HutU; COG2987 62977003152 Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013 62977003153 putative proline-specific permease; Provisional; Region: proY; PRK10580 62977003154 Arginase-like and histone-like hydrolases; Region: Arginase_HDAC; cl17011 62977003155 putative DNA modification/repair radical SAM protein; Region: rSAM_link_UDG; TIGR03916 62977003156 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 62977003157 FeS/SAM binding site; other site 62977003158 probable DNA metabolism protein; Region: SAM_7_link_chp; TIGR03915 62977003159 2-hydroxychromene-2-carboxylate isomerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NahD; COG3917 62977003160 DsbA family, 2-hydroxychromene-2-carboxylate (HCCA) isomerase subfamily; HCCA isomerase is a glutathione (GSH) dependent enzyme involved in the naphthalene catabolic pathway. It converts HCCA, a hemiketal formed spontaneously after ring cleavage of 1; Region: DsbA_HCCA_Iso; cd03022 62977003161 putative catalytic residue [active] 62977003162 Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_1; cd02432 62977003163 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 62977003164 TPR motif; other site 62977003165 binding surface 62977003166 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 62977003167 active site 62977003168 UDP-N-acetylglucosamine 2-epimerase; Region: Epimerase_2; pfam02350 62977003169 homodimer interface [polypeptide binding]; other site 62977003170 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 62977003171 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 62977003172 DXD motif; other site 62977003173 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 62977003174 DNA photolyase; Region: DNA_photolyase; pfam00875 62977003175 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095 62977003176 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 62977003177 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 62977003178 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 62977003179 Predicted protease with the C-terminal PDZ domain [General function prediction only]; Region: COG3975 62977003180 M61 glycyl aminopeptidase; Region: Peptidase_M61; pfam05299 62977003181 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 62977003182 Monomeric isocitrate dehydrogenase [Energy production and conversion]; Region: Icd; COG2838 62977003183 Monomeric isocitrate dehydrogenase; Region: IDH; cl15383 62977003184 HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822 62977003185 active site 62977003186 homotetramer interface [polypeptide binding]; other site 62977003187 Pseudouridine synthase, Escherichia coli RluE; Region: PseudoU_synth_RluE; cd02566 62977003188 pseudouridine synthase; Region: TIGR00093 62977003189 probable active site [active] 62977003190 isocitrate dehydrogenase; Validated; Region: PRK07362 62977003191 isocitrate dehydrogenase; Reviewed; Region: PRK07006 62977003192 Predicted Na+/dicarboxylate symporter [General function prediction only]; Region: COG1823 62977003193 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 62977003194 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 62977003195 ClC sycA-like chloride channel proteins. This ClC family presents in bacteria, where it facilitates acid resistance in acidic soil. Mutation of this gene (sycA) in Rhizobium tropici CIAT899 causes serious deficiencies in nodule development, nodulation...; Region: ClC_sycA_like; cd03682 62977003196 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 62977003197 putative Cl- selectivity filter; other site 62977003198 putative pore gating glutamate residue; other site 62977003199 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 62977003200 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 62977003201 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 62977003202 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 62977003203 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 62977003204 Protein of unknown function (DUF3144); Region: DUF3144; pfam11342 62977003205 Uncharacterized subgroup of the CYTH-like superfamily having an associated CHAD domain; Region: CYTH-like_Pase_CHAD; cd07756 62977003206 putative active site [active] 62977003207 putative metal binding residues [ion binding]; other site 62977003208 signature motif; other site 62977003209 putative triphosphate binding site [ion binding]; other site 62977003210 The CHAD domain is an alpha-helical domain functionally associated with some members of the adenylate cyclase family; Region: CHAD; smart00880 62977003211 Protein of unknown function (DUF962); Region: DUF962; pfam06127 62977003212 Outer membrane protein W [Cell envelope biogenesis, outer membrane]; Region: OmpW; COG3047 62977003213 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 62977003214 thiamine phosphate binding site [chemical binding]; other site 62977003215 active site 62977003216 pyrophosphate binding site [ion binding]; other site 62977003217 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 62977003218 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 62977003219 inhibitor-cofactor binding pocket; inhibition site 62977003220 pyridoxal 5'-phosphate binding site [chemical binding]; other site 62977003221 catalytic residue [active] 62977003222 Uncharacterized protein, possibly involved in utilization of glycolate and propanediol [General function prediction only]; Region: GlcG; COG3193 62977003223 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 62977003224 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 62977003225 active site 62977003226 ATP-dependent helicase HepA; Validated; Region: PRK04914 62977003227 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 62977003228 ATP binding site [chemical binding]; other site 62977003229 putative Mg++ binding site [ion binding]; other site 62977003230 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 62977003231 nucleotide binding region [chemical binding]; other site 62977003232 ATP-binding site [chemical binding]; other site 62977003233 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 62977003234 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 62977003235 dimerization interface [polypeptide binding]; other site 62977003236 DPS ferroxidase diiron center [ion binding]; other site 62977003237 ion pore; other site 62977003238 DNA-binding transcriptional repressor FabR; Provisional; Region: PRK11202 62977003239 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 62977003240 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_2; cd06216 62977003241 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 62977003242 FAD binding pocket [chemical binding]; other site 62977003243 FAD binding motif [chemical binding]; other site 62977003244 phosphate binding motif [ion binding]; other site 62977003245 beta-alpha-beta structure motif; other site 62977003246 NAD binding pocket [chemical binding]; other site 62977003247 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 62977003248 catalytic loop [active] 62977003249 iron binding site [ion binding]; other site 62977003250 Fatty acid desaturase; Region: FA_desaturase; pfam00487 62977003251 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 62977003252 putative di-iron ligands [ion binding]; other site 62977003253 Protein of unknown function (DUF541); Region: SIMPL; cl01077 62977003254 Uncharacterized conserved protein [Function unknown]; Region: COG2968 62977003255 diaminobutyrate--2-oxoglutarate aminotransferase; Provisional; Region: PRK06931 62977003256 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 62977003257 inhibitor-cofactor binding pocket; inhibition site 62977003258 pyridoxal 5'-phosphate binding site [chemical binding]; other site 62977003259 catalytic residue [active] 62977003260 DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450 62977003261 pyridoxal 5'-phosphate binding site [chemical binding]; other site 62977003262 catalytic residue [active] 62977003263 ABC-type phosphate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PstS; COG0226 62977003264 Phosphate ATP-binding cassette transporter; Region: DUF3708; pfam12501 62977003265 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 62977003266 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 62977003267 dimer interface [polypeptide binding]; other site 62977003268 conserved gate region; other site 62977003269 putative PBP binding loops; other site 62977003270 ABC-ATPase subunit interface; other site 62977003271 Domain of unknown function (DUF3333); Region: DUF3333; pfam11812 62977003272 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 62977003273 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 62977003274 dimer interface [polypeptide binding]; other site 62977003275 conserved gate region; other site 62977003276 putative PBP binding loops; other site 62977003277 ABC-ATPase subunit interface; other site 62977003278 phosphate transporter ATP-binding protein; Provisional; Region: PRK14235 62977003279 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 62977003280 Walker A/P-loop; other site 62977003281 ATP binding site [chemical binding]; other site 62977003282 Q-loop/lid; other site 62977003283 ABC transporter signature motif; other site 62977003284 Walker B; other site 62977003285 D-loop; other site 62977003286 H-loop/switch region; other site 62977003287 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 62977003288 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 62977003289 tandem repeat interface [polypeptide binding]; other site 62977003290 oligomer interface [polypeptide binding]; other site 62977003291 active site residues [active] 62977003292 Predicted membrane protein (DUF2238); Region: DUF2238; pfam09997 62977003293 adenylosuccinate lyase; Provisional; Region: PRK09285 62977003294 PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598 62977003295 tetramer interface [polypeptide binding]; other site 62977003296 active site 62977003297 putative lysogenization regulator; Reviewed; Region: PRK00218 62977003298 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 62977003299 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 62977003300 Contains a crystal structure of the Nudix hydrolase from Nitrosomonas europaea, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_2; cd03675 62977003301 nudix motif; other site 62977003302 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 62977003303 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 62977003304 active site 62977003305 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 62977003306 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 62977003307 trimer interface [polypeptide binding]; other site 62977003308 putative metal binding site [ion binding]; other site 62977003309 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 62977003310 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 62977003311 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 62977003312 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 62977003313 lipoprotein NlpD; Provisional; Region: nlpD; PRK10871 62977003314 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 62977003315 Peptidase family M23; Region: Peptidase_M23; pfam01551 62977003316 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 62977003317 Transcriptional regulator [Transcription]; Region: LysR; COG0583 62977003318 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 62977003319 putative effector binding pocket; other site 62977003320 dimerization interface [polypeptide binding]; other site 62977003321 acetylornithine aminotransferase; Provisional; Region: PRK02627 62977003322 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 62977003323 inhibitor-cofactor binding pocket; inhibition site 62977003324 pyridoxal 5'-phosphate binding site [chemical binding]; other site 62977003325 catalytic residue [active] 62977003326 Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028 62977003327 putative GSH binding site [chemical binding]; other site 62977003328 catalytic residues [active] 62977003329 alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317 62977003330 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974 62977003331 catalytic residue [active] 62977003332 TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026 62977003333 catalytic residues [active] 62977003334 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 62977003335 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 62977003336 KTSC domain; Region: KTSC; pfam13619 62977003337 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 62977003338 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 62977003339 S-adenosylmethionine binding site [chemical binding]; other site 62977003340 Protein of unknown function (DUF1653); Region: DUF1653; pfam07866 62977003341 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 62977003342 Ligand Binding Site [chemical binding]; other site 62977003343 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 62977003344 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 62977003345 N-terminal plug; other site 62977003346 ligand-binding site [chemical binding]; other site 62977003347 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 62977003348 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 62977003349 Sulfate transporter family; Region: Sulfate_transp; pfam00916 62977003350 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 62977003351 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 62977003352 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 62977003353 Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320 62977003354 active site 62977003355 purine riboside binding site [chemical binding]; other site 62977003356 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 62977003357 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 62977003358 RNA/DNA hybrid binding site [nucleotide binding]; other site 62977003359 active site 62977003360 putative transposase OrfB; Reviewed; Region: PHA02517 62977003361 HTH-like domain; Region: HTH_21; pfam13276 62977003362 Integrase core domain; Region: rve; pfam00665 62977003363 Integrase core domain; Region: rve_2; pfam13333 62977003364 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 62977003365 Transposase; Region: HTH_Tnp_1; pfam01527 62977003366 carbon storage regulator; Provisional; Region: PRK01712 62977003367 aspartate kinase; Reviewed; Region: PRK06635 62977003368 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 62977003369 putative nucleotide binding site [chemical binding]; other site 62977003370 putative catalytic residues [active] 62977003371 putative Mg ion binding site [ion binding]; other site 62977003372 putative aspartate binding site [chemical binding]; other site 62977003373 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 62977003374 putative allosteric regulatory site; other site 62977003375 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 62977003376 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 62977003377 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 62977003378 motif 1; other site 62977003379 active site 62977003380 motif 2; other site 62977003381 motif 3; other site 62977003382 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 62977003383 DHHA1 domain; Region: DHHA1; pfam02272 62977003384 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 62977003385 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 62977003386 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 62977003387 ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: PRK12421 62977003388 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 62977003389 dimer interface [polypeptide binding]; other site 62977003390 motif 1; other site 62977003391 active site 62977003392 motif 2; other site 62977003393 motif 3; other site 62977003394 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 62977003395 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 62977003396 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 62977003397 Peptidase family M48; Region: Peptidase_M48; pfam01435 62977003398 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 62977003399 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 62977003400 active site 62977003401 catalytic tetrad [active] 62977003402 DNA-binding transcriptional dual regulator Crp; Provisional; Region: PRK11753 62977003403 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 62977003404 ligand binding site [chemical binding]; other site 62977003405 flexible hinge region; other site 62977003406 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 62977003407 putative switch regulator; other site 62977003408 non-specific DNA interactions [nucleotide binding]; other site 62977003409 DNA binding site [nucleotide binding] 62977003410 sequence specific DNA binding site [nucleotide binding]; other site 62977003411 putative cAMP binding site [chemical binding]; other site 62977003412 OsmC-like protein; Region: OsmC; cl00767 62977003413 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 62977003414 Coenzyme A binding pocket [chemical binding]; other site 62977003415 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 62977003416 Clp amino terminal domain; Region: Clp_N; pfam02861 62977003417 Clp amino terminal domain; Region: Clp_N; pfam02861 62977003418 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 62977003419 Walker A motif; other site 62977003420 ATP binding site [chemical binding]; other site 62977003421 Walker B motif; other site 62977003422 arginine finger; other site 62977003423 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 62977003424 Walker A motif; other site 62977003425 ATP binding site [chemical binding]; other site 62977003426 Walker B motif; other site 62977003427 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 62977003428 dihydroxy-acid dehydratase; Provisional; Region: PRK12448 62977003429 23S rRNA m(2)G2445 methyltransferase; Provisional; Region: rlmL; PRK11783 62977003430 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 62977003431 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 62977003432 DNA methylase; Region: N6_N4_Mtase; cl17433 62977003433 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 62977003434 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 62977003435 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 62977003436 dihydroorotase; Validated; Region: pyrC; PRK09357 62977003437 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 62977003438 active site 62977003439 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 62977003440 Domain of unknown function (DUF2520); Region: DUF2520; pfam10728 62977003441 Methyltransferase domain; Region: Methyltransf_31; pfam13847 62977003442 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 62977003443 S-adenosylmethionine binding site [chemical binding]; other site 62977003444 amino acid transporter; Region: 2A0306; TIGR00909 62977003445 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 62977003446 Ligand Binding Site [chemical binding]; other site 62977003447 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 62977003448 Ligand Binding Site [chemical binding]; other site 62977003449 cyanophycin synthetase; Provisional; Region: PRK14016 62977003450 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 62977003451 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 62977003452 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 62977003453 Type 1 glutamine amidotransferase (GATase1)-like domain found in cyanophycinase; Region: GAT1_cyanophycinase; cd03145 62977003454 proposed catalytic triad [active] 62977003455 active site nucleophile [active] 62977003456 Type 1 glutamine amidotransferase (GATase1)-like domain found in cyanophycinase; Region: GAT1_cyanophycinase; cd03145 62977003457 proposed catalytic triad [active] 62977003458 active site nucleophile [active] 62977003459 Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like subfamily; subgroup includes Pseudomonas aeruginosa AotO; Region: M14_PaAOTO_like; cd06250 62977003460 Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952 62977003461 active site 62977003462 Zn binding site [ion binding]; other site 62977003463 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 62977003464 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 62977003465 putative DNA binding site [nucleotide binding]; other site 62977003466 putative Zn2+ binding site [ion binding]; other site 62977003467 AsnC family; Region: AsnC_trans_reg; pfam01037 62977003468 bifunctional succinylornithine transaminase/acetylornithine transaminase; Provisional; Region: PRK12381 62977003469 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 62977003470 inhibitor-cofactor binding pocket; inhibition site 62977003471 pyridoxal 5'-phosphate binding site [chemical binding]; other site 62977003472 catalytic residue [active] 62977003473 Arginine/ornithine N-succinyltransferase beta subunit [Amino acid transport and metabolism]; Region: AstA; COG3138 62977003474 arginine N-succinyltransferase; Region: arg_catab_AstA; TIGR03244 62977003475 succinylglutamic semialdehyde dehydrogenase; Reviewed; Region: astD; PRK09457 62977003476 N-succinylglutamate 5-semialdehyde dehydrogenase, AstD-like; Region: ALDH_SGSD_AstD; cd07095 62977003477 NAD(P) binding site [chemical binding]; other site 62977003478 catalytic residues [active] 62977003479 succinylarginine dihydrolase; Region: arg_catab_astB; TIGR03241 62977003480 Peptidase M14 Succinylglutamate desuccinylase (ASTE) subfamily; Region: M14_ASTE; cd03855 62977003481 Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952 62977003482 putative active site [active] 62977003483 Zn binding site [ion binding]; other site 62977003484 Predicted HD phosphohydrolase [General function prediction only]; Region: COG4341; cl17564 62977003485 aldolase II superfamily protein; Provisional; Region: PRK07044 62977003486 intersubunit interface [polypeptide binding]; other site 62977003487 active site 62977003488 Zn2+ binding site [ion binding]; other site 62977003489 Transcriptional regulator [Transcription]; Region: LysR; COG0583 62977003490 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 62977003491 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 62977003492 dimerization interface [polypeptide binding]; other site 62977003493 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 62977003494 Isopenicillin N synthase and related dioxygenases [General function prediction only]; Region: PcbC; COG3491 62977003495 non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226 62977003496 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171 62977003497 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 62977003498 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 62977003499 substrate binding pocket [chemical binding]; other site 62977003500 membrane-bound complex binding site; other site 62977003501 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 62977003502 dimer interface [polypeptide binding]; other site 62977003503 conserved gate region; other site 62977003504 putative PBP binding loops; other site 62977003505 ABC-ATPase subunit interface; other site 62977003506 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 62977003507 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 62977003508 Walker A/P-loop; other site 62977003509 ATP binding site [chemical binding]; other site 62977003510 Q-loop/lid; other site 62977003511 ABC transporter signature motif; other site 62977003512 Walker B; other site 62977003513 D-loop; other site 62977003514 H-loop/switch region; other site 62977003515 Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592 62977003516 agmatinase; Region: agmatinase; TIGR01230 62977003517 oligomer interface [polypeptide binding]; other site 62977003518 putative active site [active] 62977003519 Mn binding site [ion binding]; other site 62977003520 Transcriptional regulator [Transcription]; Region: LysR; COG0583 62977003521 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 62977003522 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 62977003523 dimerization interface [polypeptide binding]; other site 62977003524 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_4; cd12162 62977003525 glycerate dehydrogenase; Provisional; Region: PRK06932 62977003526 putative ligand binding site [chemical binding]; other site 62977003527 putative NAD binding site [chemical binding]; other site 62977003528 catalytic site [active] 62977003529 tRNA (guanine-N(7)-)-methyltransferase; Reviewed; Region: trmB; PRK00121 62977003530 Predicted extracellular nuclease [General function prediction only]; Region: COG2374 62977003531 YhcR_OBF_like: A subfamily of OB-fold domains similar to the OB folds of Bacillus subtilis YhcR. YhcR is a sugar-nonspecific nuclease, which is active in the presence of Ca2+ and Mn2+. It cleaves RNA endonucleolytically, producing 3'-monophosphate...; Region: YhcR_OBF_like; cd04486 62977003532 generic binding surface II; other site 62977003533 generic binding surface I; other site 62977003534 Mycoplasma pulmonis MnuA nuclease-like; Region: MnuA_DNase1-like; cd10283 62977003535 putative active site [active] 62977003536 putative catalytic site [active] 62977003537 putative Mg binding site IVb [ion binding]; other site 62977003538 putative phosphate binding site [ion binding]; other site 62977003539 putative DNA binding site [nucleotide binding]; other site 62977003540 putative Mg binding site IVa [ion binding]; other site 62977003541 glutathionine S-transferase; Provisional; Region: PRK10542 62977003542 GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057 62977003543 C-terminal domain interface [polypeptide binding]; other site 62977003544 GSH binding site (G-site) [chemical binding]; other site 62977003545 dimer interface [polypeptide binding]; other site 62977003546 C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188 62977003547 dimer interface [polypeptide binding]; other site 62977003548 N-terminal domain interface [polypeptide binding]; other site 62977003549 substrate binding pocket (H-site) [chemical binding]; other site 62977003550 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 62977003551 ThiS interaction site; other site 62977003552 putative active site [active] 62977003553 tetramer interface [polypeptide binding]; other site 62977003554 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 62977003555 thiS-thiF/thiG interaction site; other site 62977003556 Uncharacterized small membrane protein [Function unknown]; Region: COG2363 62977003557 RNA polymerase factor sigma-32; Reviewed; Region: PRK06596 62977003558 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 62977003559 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 62977003560 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 62977003561 DNA binding residues [nucleotide binding] 62977003562 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 62977003563 CPxP motif; other site 62977003564 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 62977003565 DNA-binding site [nucleotide binding]; DNA binding site 62977003566 RNA-binding motif; other site 62977003567 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 62977003568 DEAD-like helicases superfamily; Region: DEXDc; smart00487 62977003569 ATP binding site [chemical binding]; other site 62977003570 Mg++ binding site [ion binding]; other site 62977003571 motif III; other site 62977003572 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 62977003573 nucleotide binding region [chemical binding]; other site 62977003574 ATP-binding site [chemical binding]; other site 62977003575 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 62977003576 putative FMN binding site [chemical binding]; other site 62977003577 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 62977003578 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 62977003579 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 62977003580 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 62977003581 catalytic core [active] 62977003582 GspL periplasmic domain; Region: GspL_C; cl14909 62977003583 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 62977003584 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 62977003585 quinone interaction residues [chemical binding]; other site 62977003586 active site 62977003587 catalytic residues [active] 62977003588 FMN binding site [chemical binding]; other site 62977003589 substrate binding site [chemical binding]; other site 62977003590 Colicin V production protein; Region: Colicin_V; pfam02674 62977003591 amidophosphoribosyltransferase; Provisional; Region: PRK09246 62977003592 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 62977003593 active site 62977003594 tetramer interface [polypeptide binding]; other site 62977003595 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 62977003596 active site 62977003597 Peptidase family M48; Region: Peptidase_M48; cl12018 62977003598 bifunctional glyoxylate/hydroxypyruvate reductase B; Provisional; Region: PRK15409 62977003599 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 62977003600 dimerization interface [polypeptide binding]; other site 62977003601 ligand binding site [chemical binding]; other site 62977003602 NADP binding site [chemical binding]; other site 62977003603 catalytic site [active] 62977003604 Putative Zn-dependent protease, contains TPR repeats [General function prediction only]; Region: COG4783 62977003605 Peptidase family M48; Region: Peptidase_M48; pfam01435 62977003606 Yqey-like protein; Region: YqeY; pfam09424 62977003607 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 62977003608 UGMP family protein; Validated; Region: PRK09604 62977003609 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 62977003610 Carbamoyltransferase; Region: CmcH_NodU; pfam02543 62977003611 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG2607 62977003612 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 62977003613 Walker A motif; other site 62977003614 ATP binding site [chemical binding]; other site 62977003615 Walker B motif; other site 62977003616 Domain of unknown function (DUF3336); Region: DUF3336; pfam11815 62977003617 Triacylglycerol lipase 3, 4, and 5 and Sugar-Dependent 1 lipase; Region: Pat_TGL3-4-5_SDP1; cd07206 62977003618 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 62977003619 active site 62977003620 nucleophile elbow; other site 62977003621 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 62977003622 active site 62977003623 ATP binding site [chemical binding]; other site 62977003624 substrate binding site [chemical binding]; other site 62977003625 activation loop (A-loop); other site 62977003626 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 62977003627 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 62977003628 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 62977003629 Protein of unknown function (DUF2726); Region: DUF2726; pfam10881 62977003630 aromatic amino acid transporter; Provisional; Region: PRK10238 62977003631 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 62977003632 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 62977003633 putative DNA binding site [nucleotide binding]; other site 62977003634 putative Zn2+ binding site [ion binding]; other site 62977003635 AsnC family; Region: AsnC_trans_reg; pfam01037 62977003636 Uncharacterized conserved protein [Function unknown]; Region: COG1284 62977003637 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 62977003638 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 62977003639 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 62977003640 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 62977003641 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 62977003642 Uncharacterized conserved protein [Function unknown]; Region: COG0327 62977003643 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371 62977003644 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 62977003645 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 62977003646 protein binding site [polypeptide binding]; other site 62977003647 Protein of unknown function (DUF1449); Region: DUF1449; pfam07290 62977003648 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 62977003649 iron-sulfur cluster [ion binding]; other site 62977003650 [2Fe-2S] cluster binding site [ion binding]; other site 62977003651 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 62977003652 Adenosine kinase (AK) catalyzes the phosphorylation of ribofuranosyl-containing nucleoside analogues at the 5'-hydroxyl using ATP or GTP as the phosphate donor.The physiological function of AK is associated with the regulation of extracellular...; Region: adenosine_kinase; cd01168 62977003653 substrate binding site [chemical binding]; other site 62977003654 ATP binding site [chemical binding]; other site 62977003655 Predicted Zn-dependent peptidases, insulinase-like [General function prediction only]; Region: COG1026 62977003656 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 62977003657 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 62977003658 Peptidase M16C associated; Region: M16C_assoc; pfam08367 62977003659 The outer membrane phospholipase A (OMPLA) is an integral membrane enzyme that catalyses the hydrolysis of acylester bonds in phospholipids using calcium as a cofactor. The enzyme has a fold of transmembrane beta-barrels and is widespread among...; Region: OMPLA; cd00541 62977003660 dimerization interface [polypeptide binding]; other site 62977003661 substrate binding site [chemical binding]; other site 62977003662 active site 62977003663 calcium binding site [ion binding]; other site 62977003664 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 62977003665 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 62977003666 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 62977003667 TrkA-N domain; Region: TrkA_N; pfam02254 62977003668 threonine dehydratase; Reviewed; Region: PRK09224 62977003669 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 62977003670 tetramer interface [polypeptide binding]; other site 62977003671 pyridoxal 5'-phosphate binding site [chemical binding]; other site 62977003672 catalytic residue [active] 62977003673 First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906 62977003674 putative Ile/Val binding site [chemical binding]; other site 62977003675 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 62977003676 putative Ile/Val binding site [chemical binding]; other site 62977003677 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 62977003678 tetramer (dimer of dimers) interface [polypeptide binding]; other site 62977003679 active site 62977003680 dimer interface [polypeptide binding]; other site 62977003681 Protein of unknown function DUF45; Region: DUF45; pfam01863 62977003682 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 62977003683 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 62977003684 Membrane-anchored protein predicted to be involved in regulation of amylopullulanase [Carbohydrate transport and metabolism]; Region: COG4945 62977003685 Uncharacterized conserved protein [Function unknown]; Region: COG2127 62977003686 ATP-dependent Clp protease ATP-binding subunit clpA; Region: ClpA; TIGR02639 62977003687 Clp amino terminal domain; Region: Clp_N; pfam02861 62977003688 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 62977003689 Walker A motif; other site 62977003690 ATP binding site [chemical binding]; other site 62977003691 Walker B motif; other site 62977003692 arginine finger; other site 62977003693 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 62977003694 Walker A motif; other site 62977003695 ATP binding site [chemical binding]; other site 62977003696 Walker B motif; other site 62977003697 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 62977003698 hypothetical protein; Provisional; Region: PRK02237 62977003699 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 62977003700 ornithine carbamoyltransferase; Provisional; Region: PRK00779 62977003701 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 62977003702 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 62977003703 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 62977003704 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 62977003705 AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246 62977003706 nitrogen regulation protein NR(I); Region: ntrC; TIGR01818 62977003707 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 62977003708 active site 62977003709 phosphorylation site [posttranslational modification] 62977003710 intermolecular recognition site; other site 62977003711 dimerization interface [polypeptide binding]; other site 62977003712 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 62977003713 Walker A motif; other site 62977003714 ATP binding site [chemical binding]; other site 62977003715 Walker B motif; other site 62977003716 arginine finger; other site 62977003717 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 62977003718 PAS domain; Region: PAS; smart00091 62977003719 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 62977003720 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 62977003721 dimer interface [polypeptide binding]; other site 62977003722 phosphorylation site [posttranslational modification] 62977003723 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 62977003724 ATP binding site [chemical binding]; other site 62977003725 Mg2+ binding site [ion binding]; other site 62977003726 G-X-G motif; other site 62977003727 ribosomal protein S12 methylthiotransferase; Provisional; Region: rimO; PRK14862 62977003728 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 62977003729 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 62977003730 FeS/SAM binding site; other site 62977003731 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 62977003732 putative nucleotide binding site [chemical binding]; other site 62977003733 uridine monophosphate binding site [chemical binding]; other site 62977003734 homohexameric interface [polypeptide binding]; other site 62977003735 ribosome recycling factor; Reviewed; Region: frr; PRK00083 62977003736 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 62977003737 hinge region; other site 62977003738 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 62977003739 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 62977003740 catalytic residue [active] 62977003741 putative FPP diphosphate binding site; other site 62977003742 putative FPP binding hydrophobic cleft; other site 62977003743 dimer interface [polypeptide binding]; other site 62977003744 putative IPP diphosphate binding site; other site 62977003745 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 62977003746 CDP-diglyceride synthase; Provisional; Region: cdsA; PRK11624 62977003747 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 62977003748 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 62977003749 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 62977003750 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 62977003751 zinc metallopeptidase RseP; Provisional; Region: PRK10779 62977003752 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 62977003753 active site 62977003754 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 62977003755 protein binding site [polypeptide binding]; other site 62977003756 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 62977003757 protein binding site [polypeptide binding]; other site 62977003758 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 62977003759 putative substrate binding region [chemical binding]; other site 62977003760 outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303 62977003761 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 62977003762 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 62977003763 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 62977003764 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 62977003765 Surface antigen; Region: Bac_surface_Ag; pfam01103 62977003766 Outer membrane protein (OmpH-like); Region: OmpH; pfam03938 62977003767 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 62977003768 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 62977003769 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 62977003770 trimer interface [polypeptide binding]; other site 62977003771 active site 62977003772 UDP-GlcNAc binding site [chemical binding]; other site 62977003773 lipid binding site [chemical binding]; lipid-binding site 62977003774 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 62977003775 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 62977003776 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 62977003777 active site 62977003778 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1729 62977003779 recombination regulator RecX; Reviewed; Region: recX; PRK00117 62977003780 recombinase A; Provisional; Region: recA; PRK09354 62977003781 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 62977003782 hexamer interface [polypeptide binding]; other site 62977003783 Walker A motif; other site 62977003784 ATP binding site [chemical binding]; other site 62977003785 Walker B motif; other site 62977003786 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 62977003787 RNA binding surface [nucleotide binding]; other site 62977003788 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 62977003789 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 62977003790 active site 62977003791 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 62977003792 catalytic core [active] 62977003793 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 62977003794 CC3(TIP30)-like, atypical (a) SDRs; Region: CC3_like_SDR_a; cd05250 62977003795 NADH(P)-binding; Region: NAD_binding_10; pfam13460 62977003796 NAD binding site [chemical binding]; other site 62977003797 active site 62977003798 ribonuclease activity regulator protein RraA; Provisional; Region: PRK09372 62977003799 GST_N family, 2 repeats of the N-terminal domain of soluble GSTs (2 GST_N) subfamily; composed of uncharacterized proteins. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a...; Region: GST_N_2GST_N; cd03041 62977003800 putative C-terminal domain interface [polypeptide binding]; other site 62977003801 putative GSH binding site (G-site) [chemical binding]; other site 62977003802 putative dimer interface [polypeptide binding]; other site 62977003803 GST_N family, 2 repeats of the N-terminal domain of soluble GSTs (2 GST_N) subfamily; composed of uncharacterized proteins. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a...; Region: GST_N_2GST_N; cd03041 62977003804 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 62977003805 putative C-terminal domain interface [polypeptide binding]; other site 62977003806 putative GSH binding site (G-site) [chemical binding]; other site 62977003807 putative dimer interface [polypeptide binding]; other site 62977003808 Dyp-type peroxidase family; Region: Dyp_perox; cl01067 62977003809 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 62977003810 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 62977003811 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 62977003812 ATP binding site [chemical binding]; other site 62977003813 putative Mg++ binding site [ion binding]; other site 62977003814 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 62977003815 nucleotide binding region [chemical binding]; other site 62977003816 ATP-binding site [chemical binding]; other site 62977003817 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 62977003818 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 62977003819 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 62977003820 cyclase homology domain; Region: CHD; cd07302 62977003821 nucleotidyl binding site; other site 62977003822 metal binding site [ion binding]; metal-binding site 62977003823 dimer interface [polypeptide binding]; other site 62977003824 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 62977003825 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 62977003826 catalytic loop [active] 62977003827 iron binding site [ion binding]; other site 62977003828 chaperone protein HscA; Provisional; Region: hscA; PRK05183 62977003829 Nucleotide-binding domain of HscA and similar proteins; Region: HscA_like_NBD; cd10236 62977003830 nucleotide binding site [chemical binding]; other site 62977003831 putative NEF/HSP70 interaction site [polypeptide binding]; other site 62977003832 SBD interface [polypeptide binding]; other site 62977003833 co-chaperone HscB; Provisional; Region: hscB; PRK05014 62977003834 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 62977003835 HSP70 interaction site [polypeptide binding]; other site 62977003836 HSCB C-terminal oligomerisation domain; Region: HSCB_C; pfam07743 62977003837 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 62977003838 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 62977003839 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 62977003840 trimerization site [polypeptide binding]; other site 62977003841 active site 62977003842 cysteine desulfurase; Provisional; Region: PRK14012 62977003843 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 62977003844 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 62977003845 catalytic residue [active] 62977003846 Transcriptional regulator; Region: Rrf2; cl17282 62977003847 Rrf2 family protein; Region: rrf2_super; TIGR00738 62977003848 Poly(hydroxyalcanoate) granule associated protein (phasin); Region: Phasin; pfam05597 62977003849 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 62977003850 IHF dimer interface [polypeptide binding]; other site 62977003851 IHF - DNA interface [nucleotide binding]; other site 62977003852 periplasmic folding chaperone; Provisional; Region: PRK10788 62977003853 SurA N-terminal domain; Region: SurA_N_3; cl07813 62977003854 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 62977003855 Cupin; Region: Cupin_6; pfam12852 62977003856 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 62977003857 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 62977003858 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 62977003859 Alkane hydroxylase is a bacterial, integral-membrane di-iron enzyme that shares a requirement for iron and oxygen for activity similar to that of the non-heme integral-membrane acyl coenzyme A (CoA) desaturases and acyl lipid desaturases. The alk genes...; Region: Alkane-hydroxylase; cd03512 62977003860 Fatty acid desaturase; Region: FA_desaturase; pfam00487 62977003861 Di-iron ligands [ion binding]; other site 62977003862 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 62977003863 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 62977003864 active site 62977003865 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 62977003866 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 62977003867 active site 62977003868 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 62977003869 ABC1 family; Region: ABC1; cl17513 62977003870 Protein of unknown function (DUF1304); Region: DUF1304; pfam06993 62977003871 putrescine transporter; Provisional; Region: potE; PRK10655 62977003872 Spore germination protein; Region: Spore_permease; cl17796 62977003873 Homocysteine/selenocysteine methylase (S-methylmethionine-dependent) [Amino acid transport and metabolism]; Region: MHT1; COG2040 62977003874 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 62977003875 dihydroorotase; Reviewed; Region: PRK09236 62977003876 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 62977003877 Dihydroorotase (DHOase), subgroup IIb; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This group contains the archeal members of the DHOase family; Region: DHOase_IIb; cd01318 62977003878 active site 62977003879 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 62977003880 Gamma carbonic anhydrases (CA): Carbonic anhydrases are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism, involving the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide, followed...; Region: LbH_gamma_CA; cd00710 62977003881 trimer interface [polypeptide binding]; other site 62977003882 active site 62977003883 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 62977003884 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 62977003885 dimer interface [polypeptide binding]; other site 62977003886 phosphorylation site [posttranslational modification] 62977003887 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 62977003888 ATP binding site [chemical binding]; other site 62977003889 Mg2+ binding site [ion binding]; other site 62977003890 G-X-G motif; other site 62977003891 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 62977003892 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 62977003893 active site 62977003894 phosphorylation site [posttranslational modification] 62977003895 intermolecular recognition site; other site 62977003896 dimerization interface [polypeptide binding]; other site 62977003897 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 62977003898 DNA binding site [nucleotide binding] 62977003899 putative metal dependent hydrolase; Provisional; Region: PRK11598 62977003900 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 62977003901 Sulfatase; Region: Sulfatase; pfam00884 62977003902 salicylate 1-monooxygenase; Region: salicylate_mono; TIGR03219 62977003903 Transcriptional regulator [Transcription]; Region: LysR; COG0583 62977003904 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 62977003905 The C-terminal substrate binding domain of LysR-type transcriptional regulators that are involved in the catabolism of dinitrotoluene, naphthalene and gamma-hexachlorohexane; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_NahR_LinR_like; cd08459 62977003906 substrate binding pocket [chemical binding]; other site 62977003907 dimerization interface [polypeptide binding]; other site 62977003908 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 62977003909 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 62977003910 Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; pfam03349 62977003911 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 62977003912 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 62977003913 Benzyl alcohol dehydrogenase; Region: benzyl_alcohol_DH; cd08278 62977003914 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 62977003915 catalytic Zn binding site [ion binding]; other site 62977003916 NAD binding site [chemical binding]; other site 62977003917 structural Zn binding site [ion binding]; other site 62977003918 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 62977003919 NAD-dependent benzaldehyde dehydrogenase II-like; Region: ALDH_BenzADH; cd07152 62977003920 NAD(P) binding site [chemical binding]; other site 62977003921 catalytic residues [active] 62977003922 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 62977003923 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 62977003924 Walker A motif; other site 62977003925 ATP binding site [chemical binding]; other site 62977003926 Walker B motif; other site 62977003927 arginine finger; other site 62977003928 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 62977003929 DNA-binding interface [nucleotide binding]; DNA binding site 62977003930 outer membrane porin, OprD family; Region: OprD; pfam03573 62977003931 benzoate transport; Region: 2A0115; TIGR00895 62977003932 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 62977003933 putative substrate translocation pore; other site 62977003934 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 62977003935 Transcriptional regulator [Transcription]; Region: LysR; COG0583 62977003936 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 62977003937 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in benzoate catabolism; contains the type 2 periplasmic binding fold; Region: PBP2_BenM_CatM_CatR; cd08445 62977003938 dimerizarion interface [polypeptide binding]; other site 62977003939 CrgA pocket; other site 62977003940 substrate binding pocket [chemical binding]; other site 62977003941 benzoate 1,2-dioxygenase, large subunit; Region: benzo_1_2_benA; TIGR03229 62977003942 Rieske non-heme iron oxygenase (RO) family, 2-Halobenzoate 1,2-dioxygenase (HBDO) subfamily, N-terminal Rieske domain of the oxygenase alpha subunit; ROs comprise a large class of aromatic ring-hydroxylating dioxygenases that enable microorganisms to...; Region: Rieske_RO_Alpha_HBDO; cd03542 62977003943 C-terminal catalytic domain of the oxygenase alpha subunit of Pseudomonas resinovorans strain CA10 anthranilate 1,2-dioxygenase and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_AntDO-like; cd08879 62977003944 putative alpha subunit interface [polypeptide binding]; other site 62977003945 putative active site [active] 62977003946 putative substrate binding site [chemical binding]; other site 62977003947 Fe binding site [ion binding]; other site 62977003948 Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667 62977003949 inter-subunit interface; other site 62977003950 anthranilate dioxygenase reductase; Provisional; Region: antC; PRK11872 62977003951 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 62977003952 catalytic loop [active] 62977003953 iron binding site [ion binding]; other site 62977003954 Benzoate dioxygenase reductase (BenDO) FAD/NAD binding domain. Oxygenases oxidize hydrocarbons using dioxygen as the oxidant. As a Class I bacterial dioxygenases, benzoate dioxygenase like proteins combine an [2Fe-2S] cluster containing N-terminal...; Region: BenDO_FAD_NAD; cd06209 62977003955 FAD binding pocket [chemical binding]; other site 62977003956 FAD binding motif [chemical binding]; other site 62977003957 phosphate binding motif [ion binding]; other site 62977003958 beta-alpha-beta structure motif; other site 62977003959 NAD binding pocket [chemical binding]; other site 62977003960 1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate dehydrogenase; Provisional; Region: benD; PRK12823 62977003961 1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate dehydrogenase (DHB DH)-like, classical (c) SDR; Region: DHB_DH-like_SDR_c; cd08937 62977003962 putative NAD(P) binding site [chemical binding]; other site 62977003963 active site 62977003964 benzoate transporter; Region: benE; TIGR00843 62977003965 Benzoate membrane transport protein; Region: BenE; pfam03594 62977003966 catechol 1,2-dioxygenase, proteobacterial; Region: catechol_proteo; TIGR02439 62977003967 Catechol 1,2 dioxygenase (1,2-CTD) catalyzes an intradiol cleavage reaction of catechol to form cis,cis-muconate. 1,2-CTDs is homodimers with one catalytic non-heme ferric ion per monomer. They belong to the aromatic dioxygenase family, a family of...; Region: 1,2-CTD; cd03460 62977003968 dimer interface [polypeptide binding]; other site 62977003969 active site 62977003970 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 62977003971 G1 box; other site 62977003972 GTP/Mg2+ binding site [chemical binding]; other site 62977003973 G2 box; other site 62977003974 Switch I region; other site 62977003975 G3 box; other site 62977003976 Switch II region; other site 62977003977 G4 box; other site 62977003978 G5 box; other site 62977003979 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 62977003980 Dynamin family; Region: Dynamin_N; pfam00350 62977003981 G1 box; other site 62977003982 GTP/Mg2+ binding site [chemical binding]; other site 62977003983 G2 box; other site 62977003984 Switch I region; other site 62977003985 G3 box; other site 62977003986 Switch II region; other site 62977003987 G4 box; other site 62977003988 G5 box; other site 62977003989 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 62977003990 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 62977003991 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in benzoate catabolism; contains the type 2 periplasmic binding fold; Region: PBP2_BenM_CatM_CatR; cd08445 62977003992 dimerizarion interface [polypeptide binding]; other site 62977003993 CrgA pocket; other site 62977003994 substrate binding pocket [chemical binding]; other site 62977003995 muconate and chloromuconate cycloisomerases; Region: mucon_cyclo; TIGR02534 62977003996 Muconate Lactonizing Enzyme (MLE), an homooctameric enzyme, catalyses the conversion of cis,cis-muconate (CCM) to muconolactone (ML) in the catechol branch of the beta-ketoadipate pathway. This pathway is used in soil microbes to breakdown lignin-derived...; Region: MLE; cd03318 62977003997 octamer interface [polypeptide binding]; other site 62977003998 active site 62977003999 muconolactone delta-isomerase; Region: muco_delta; TIGR03221 62977004000 3-oxoacid CoA-transferase, A subunit; Region: pcaI_scoA_fam; TIGR02429 62977004001 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 62977004002 beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050 62977004003 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 62977004004 dimer interface [polypeptide binding]; other site 62977004005 active site 62977004006 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 62977004007 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 62977004008 4-aminobutyrate aminotransferase and related aminotransferases [Amino acid transport and metabolism]; Region: GabT; COG0160 62977004009 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 62977004010 inhibitor-cofactor binding pocket; inhibition site 62977004011 pyridoxal 5'-phosphate binding site [chemical binding]; other site 62977004012 catalytic residue [active] 62977004013 Predicted transcriptional regulators [Transcription]; Region: COG1733 62977004014 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 62977004015 Arginate lyase and other MDR family members; Region: AL_MDR; cd08252 62977004016 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817 62977004017 putative NAD(P) binding site [chemical binding]; other site 62977004018 dimer interface [polypeptide binding]; other site 62977004019 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 62977004020 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 62977004021 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 62977004022 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 62977004023 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 62977004024 active site 62977004025 substrate binding site [chemical binding]; other site 62977004026 Phosphotransferase enzyme family; Region: APH; pfam01636 62977004027 ATP binding site [chemical binding]; other site 62977004028 ethanolamine permease; Region: 2A0305; TIGR00908 62977004029 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 62977004030 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 62977004031 N-terminal plug; other site 62977004032 ligand-binding site [chemical binding]; other site 62977004033 Bestrophin, RFP-TM, chloride channel; Region: Bestrophin; pfam01062 62977004034 Transcriptional regulators [Transcription]; Region: FadR; COG2186 62977004035 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 62977004036 DNA-binding site [nucleotide binding]; DNA binding site 62977004037 FCD domain; Region: FCD; pfam07729 62977004038 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 62977004039 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 62977004040 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 62977004041 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 62977004042 Walker A/P-loop; other site 62977004043 ATP binding site [chemical binding]; other site 62977004044 Q-loop/lid; other site 62977004045 ABC transporter signature motif; other site 62977004046 Walker B; other site 62977004047 D-loop; other site 62977004048 H-loop/switch region; other site 62977004049 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 62977004050 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 62977004051 dimer interface [polypeptide binding]; other site 62977004052 conserved gate region; other site 62977004053 putative PBP binding loops; other site 62977004054 ABC-ATPase subunit interface; other site 62977004055 amidohydrolase; Provisional; Region: PRK12393 62977004056 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 62977004057 active site 62977004058 putative substrate binding pocket [chemical binding]; other site 62977004059 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 62977004060 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 62977004061 DNA binding residues [nucleotide binding] 62977004062 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 62977004063 FecR protein; Region: FecR; pfam04773 62977004064 Secretin and TonB N terminus short domain; Region: STN; pfam07660 62977004065 TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786 62977004066 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 62977004067 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 62977004068 TPR repeat; Region: TPR_11; pfam13414 62977004069 Protein of unknown function (DUF560); Region: DUF560; pfam04575 62977004070 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 62977004071 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cd00232 62977004072 heme binding pocket [chemical binding]; other site 62977004073 heme ligand [chemical binding]; other site 62977004074 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2832 62977004075 Restriction endonuclease; Region: Mrr_cat; pfam04471 62977004076 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 62977004077 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 62977004078 active site 62977004079 HIGH motif; other site 62977004080 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 62977004081 KMSKS motif; other site 62977004082 Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963 62977004083 tRNA binding surface [nucleotide binding]; other site 62977004084 anticodon binding site; other site 62977004085 D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892 62977004086 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 62977004087 putative active site [active] 62977004088 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 62977004089 HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662 62977004090 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 62977004091 active site 62977004092 motif I; other site 62977004093 motif II; other site 62977004094 Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835 62977004095 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3117; cl01200 62977004096 lipopolysaccharide transport periplasmic protein LptA; Region: outer_YhbN_LptA; TIGR03002 62977004097 OstA-like protein; Region: OstA; pfam03968 62977004098 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 62977004099 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 62977004100 Walker A/P-loop; other site 62977004101 ATP binding site [chemical binding]; other site 62977004102 Q-loop/lid; other site 62977004103 ABC transporter signature motif; other site 62977004104 Walker B; other site 62977004105 D-loop; other site 62977004106 H-loop/switch region; other site 62977004107 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 62977004108 type I secretion system ATPase, LssB family; Region: type_I_sec_LssB; TIGR03375 62977004109 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 62977004110 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 62977004111 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 62977004112 Walker A/P-loop; other site 62977004113 ATP binding site [chemical binding]; other site 62977004114 Q-loop/lid; other site 62977004115 ABC transporter signature motif; other site 62977004116 Walker B; other site 62977004117 D-loop; other site 62977004118 H-loop/switch region; other site 62977004119 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 62977004120 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 62977004121 HlyD family secretion protein; Region: HlyD_3; pfam13437 62977004122 Uncharacterized conserved protein [Function unknown]; Region: COG1739 62977004123 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 62977004124 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 62977004125 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 62977004126 putative trimer interface [polypeptide binding]; other site 62977004127 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 62977004128 trimer interface [polypeptide binding]; other site 62977004129 active site 62977004130 substrate binding site [chemical binding]; other site 62977004131 putative CoA binding site [chemical binding]; other site 62977004132 CoA binding site [chemical binding]; other site 62977004133 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 62977004134 Ligand Binding Site [chemical binding]; other site 62977004135 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 62977004136 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 62977004137 S-adenosylmethionine binding site [chemical binding]; other site 62977004138 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3108 62977004139 Ferredoxin [Energy production and conversion]; Region: COG1146 62977004140 4Fe-4S binding domain; Region: Fer4; cl02805 62977004141 Domain of unknown function (DUF3470); Region: DUF3470; pfam11953 62977004142 Sensors of blue-light using FAD; Region: BLUF; smart01034 62977004143 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 62977004144 MutS domain I; Region: MutS_I; pfam01624 62977004145 MutS domain II; Region: MutS_II; pfam05188 62977004146 MutS domain III; Region: MutS_III; pfam05192 62977004147 MutS domain V; Region: MutS_V; pfam00488 62977004148 Walker A/P-loop; other site 62977004149 ATP binding site [chemical binding]; other site 62977004150 Q-loop/lid; other site 62977004151 ABC transporter signature motif; other site 62977004152 Walker B; other site 62977004153 D-loop; other site 62977004154 H-loop/switch region; other site 62977004155 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 62977004156 Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; pfam00596 62977004157 alkanesulfonate monooxygenase; Provisional; Region: PRK00719 62977004158 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 62977004159 active site 62977004160 dimer interface [polypeptide binding]; other site 62977004161 non-prolyl cis peptide bond; other site 62977004162 insertion regions; other site 62977004163 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_17; cd08503 62977004164 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 62977004165 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 62977004166 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 62977004167 dimer interface [polypeptide binding]; other site 62977004168 conserved gate region; other site 62977004169 putative PBP binding loops; other site 62977004170 ABC-ATPase subunit interface; other site 62977004171 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 62977004172 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 62977004173 dimer interface [polypeptide binding]; other site 62977004174 conserved gate region; other site 62977004175 putative PBP binding loops; other site 62977004176 ABC-ATPase subunit interface; other site 62977004177 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 62977004178 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 62977004179 Walker A/P-loop; other site 62977004180 ATP binding site [chemical binding]; other site 62977004181 Q-loop/lid; other site 62977004182 ABC transporter signature motif; other site 62977004183 Walker B; other site 62977004184 D-loop; other site 62977004185 H-loop/switch region; other site 62977004186 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 62977004187 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 62977004188 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 62977004189 Walker A/P-loop; other site 62977004190 ATP binding site [chemical binding]; other site 62977004191 Q-loop/lid; other site 62977004192 ABC transporter signature motif; other site 62977004193 Walker B; other site 62977004194 D-loop; other site 62977004195 H-loop/switch region; other site 62977004196 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 62977004197 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 62977004198 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 62977004199 active site 62977004200 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 62977004201 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 62977004202 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 62977004203 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 62977004204 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 62977004205 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 62977004206 Walker A/P-loop; other site 62977004207 ATP binding site [chemical binding]; other site 62977004208 Q-loop/lid; other site 62977004209 ABC transporter signature motif; other site 62977004210 Walker B; other site 62977004211 D-loop; other site 62977004212 H-loop/switch region; other site 62977004213 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 62977004214 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 62977004215 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 62977004216 Walker A/P-loop; other site 62977004217 ATP binding site [chemical binding]; other site 62977004218 Q-loop/lid; other site 62977004219 ABC transporter signature motif; other site 62977004220 Walker B; other site 62977004221 D-loop; other site 62977004222 H-loop/switch region; other site 62977004223 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 62977004224 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 62977004225 N-terminal plug; other site 62977004226 ligand-binding site [chemical binding]; other site 62977004227 Secretory lipase; Region: LIP; pfam03583 62977004228 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 62977004229 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 62977004230 dimer interface [polypeptide binding]; other site 62977004231 active site 62977004232 non-prolyl cis peptide bond; other site 62977004233 insertion regions; other site 62977004234 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 62977004235 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 62977004236 Walker A motif; other site 62977004237 ATP binding site [chemical binding]; other site 62977004238 Walker B motif; other site 62977004239 arginine finger; other site 62977004240 Sec-independent protein translocase protein (TatC); Region: TatC; cl00521 62977004241 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 62977004242 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 62977004243 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 62977004244 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 62977004245 Walker A/P-loop; other site 62977004246 ATP binding site [chemical binding]; other site 62977004247 Q-loop/lid; other site 62977004248 ABC transporter signature motif; other site 62977004249 Walker B; other site 62977004250 D-loop; other site 62977004251 H-loop/switch region; other site 62977004252 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 62977004253 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 62977004254 dimer interface [polypeptide binding]; other site 62977004255 conserved gate region; other site 62977004256 ABC-ATPase subunit interface; other site 62977004257 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 62977004258 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 62977004259 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 62977004260 membrane-bound complex binding site; other site 62977004261 hinge residues; other site 62977004262 alkanesulfonate monooxygenase, FMNH(2)-dependent; Region: alk_sulf_monoox; TIGR03565 62977004263 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 62977004264 active site 62977004265 dimer interface [polypeptide binding]; other site 62977004266 non-prolyl cis peptide bond; other site 62977004267 insertion regions; other site 62977004268 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 62977004269 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 62977004270 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 62977004271 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 62977004272 TolR protein; Region: tolR; TIGR02801 62977004273 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_17; cd08503 62977004274 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 62977004275 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 62977004276 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 62977004277 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 62977004278 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 62977004279 N-terminal plug; other site 62977004280 ligand-binding site [chemical binding]; other site 62977004281 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 62977004282 alkanesulfonate monooxygenase, FMNH(2)-dependent; Region: alk_sulf_monoox; TIGR03565 62977004283 active site 62977004284 dimer interface [polypeptide binding]; other site 62977004285 non-prolyl cis peptide bond; other site 62977004286 insertion regions; other site 62977004287 tricarballylate utilization protein B; Provisional; Region: PRK15033 62977004288 tricarballylate dehydrogenase; Validated; Region: PRK08274 62977004289 Alanine dehydrogenase/PNT, C-terminal domain; Region: AlaDh_PNT_C; smart01002 62977004290 nitrogen assimilation transcriptional regulator; Provisional; Region: PRK11233 62977004291 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 62977004292 The C-teminal substrate binding domain of LysR-like nitrogen assimilation control (NAC) protein, contains the type 2 periplasmic binding fold; Region: PBP2_Nac; cd08433 62977004293 putative dimerization interface [polypeptide binding]; other site 62977004294 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 62977004295 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 62977004296 citrate-proton symporter; Provisional; Region: PRK15075 62977004297 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 62977004298 putative substrate translocation pore; other site 62977004299 Transcriptional regulator [Transcription]; Region: LysR; COG0583 62977004300 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 62977004301 The C-teminal substrate binding domain of LysR-like nitrogen assimilation control (NAC) protein, contains the type 2 periplasmic binding fold; Region: PBP2_Nac; cd08433 62977004302 putative dimerization interface [polypeptide binding]; other site 62977004303 Predicted transcriptional regulators [Transcription]; Region: COG1733 62977004304 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 62977004305 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687 62977004306 Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118 62977004307 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 62977004308 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 62977004309 C-terminal domain interface [polypeptide binding]; other site 62977004310 GSH binding site (G-site) [chemical binding]; other site 62977004311 dimer interface [polypeptide binding]; other site 62977004312 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299 62977004313 substrate binding pocket (H-site) [chemical binding]; other site 62977004314 N-terminal domain interface [polypeptide binding]; other site 62977004315 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 62977004316 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 62977004317 NAD(P) binding site [chemical binding]; other site 62977004318 active site 62977004319 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 62977004320 active site 62977004321 DDE superfamily endonuclease; Region: DDE_4_2; pfam13613 62977004322 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 62977004323 active site 62977004324 GlcNAc-PI de-N-acetylase; Region: PIG-L; pfam02585 62977004325 Methyltransferase domain; Region: Methyltransf_23; pfam13489 62977004326 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 62977004327 S-adenosylmethionine binding site [chemical binding]; other site 62977004328 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 62977004329 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 62977004330 active site 62977004331 MarR family; Region: MarR_2; cl17246 62977004332 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 62977004333 active site 62977004334 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 62977004335 Integrase core domain; Region: rve_3; cl15866 62977004336 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 62977004337 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08217 62977004338 17hydroxysteroid dehydrogenase type 10 (HSD10)-like, classical (c) SDRs; Region: HSD10-like_SDR_c; cd05371 62977004339 NAD binding site [chemical binding]; other site 62977004340 homodimer interface [polypeptide binding]; other site 62977004341 homotetramer interface [polypeptide binding]; other site 62977004342 active site 62977004343 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 62977004344 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 62977004345 active site 62977004346 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 62977004347 putative active site [active] 62977004348 putative substrate binding site [chemical binding]; other site 62977004349 ATP binding site [chemical binding]; other site 62977004350 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 62977004351 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 62977004352 substrate binding site [chemical binding]; other site 62977004353 oxyanion hole (OAH) forming residues; other site 62977004354 trimer interface [polypeptide binding]; other site 62977004355 acetyl-CoA acetyltransferase; Provisional; Region: PRK06504 62977004356 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 62977004357 dimer interface [polypeptide binding]; other site 62977004358 active site 62977004359 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 62977004360 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 62977004361 FMN binding site [chemical binding]; other site 62977004362 substrate binding site [chemical binding]; other site 62977004363 putative catalytic residue [active] 62977004364 enoyl-CoA hydratase; Provisional; Region: PRK06494 62977004365 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 62977004366 substrate binding site [chemical binding]; other site 62977004367 oxyanion hole (OAH) forming residues; other site 62977004368 trimer interface [polypeptide binding]; other site 62977004369 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 62977004370 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08276 62977004371 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 62977004372 acyl-activating enzyme (AAE) consensus motif; other site 62977004373 putative AMP binding site [chemical binding]; other site 62977004374 putative active site [active] 62977004375 acyl-activating enzyme (AAE) consensus motif; other site 62977004376 putative CoA binding site [chemical binding]; other site 62977004377 Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; pfam13557 62977004378 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 62977004379 Cytochrome P450; Region: p450; cl12078 62977004380 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 62977004381 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 62977004382 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 62977004383 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 62977004384 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 62977004385 NAD(P) binding site [chemical binding]; other site 62977004386 catalytic residues [active] 62977004387 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 62977004388 Benzyl alcohol dehydrogenase; Region: benzyl_alcohol_DH; cd08278 62977004389 catalytic Zn binding site [ion binding]; other site 62977004390 NAD binding site [chemical binding]; other site 62977004391 structural Zn binding site [ion binding]; other site 62977004392 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 62977004393 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 62977004394 catalytic loop [active] 62977004395 iron binding site [ion binding]; other site 62977004396 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 62977004397 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 62977004398 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 62977004399 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 62977004400 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 62977004401 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 62977004402 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 62977004403 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 62977004404 catalytic residue [active] 62977004405 Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762 62977004406 serine O-acetyltransferase; Region: cysE; TIGR01172 62977004407 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 62977004408 trimer interface [polypeptide binding]; other site 62977004409 active site 62977004410 substrate binding site [chemical binding]; other site 62977004411 CoA binding site [chemical binding]; other site 62977004412 Member of the Rhodanese Homology Domain superfamily, subgroup 1. This CD includes the putative rhodanese-related sulfurtransferases of several uncharacterized proteins; Region: RHOD_1; cd01522 62977004413 active site residue [active] 62977004414 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 62977004415 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 62977004416 dimer interface [polypeptide binding]; other site 62977004417 conserved gate region; other site 62977004418 putative PBP binding loops; other site 62977004419 ABC-ATPase subunit interface; other site 62977004420 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 62977004421 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 62977004422 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 62977004423 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 62977004424 Walker A/P-loop; other site 62977004425 ATP binding site [chemical binding]; other site 62977004426 Q-loop/lid; other site 62977004427 ABC transporter signature motif; other site 62977004428 Walker B; other site 62977004429 D-loop; other site 62977004430 H-loop/switch region; other site 62977004431 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 62977004432 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 62977004433 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 62977004434 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 62977004435 TolR protein; Region: tolR; TIGR02801 62977004436 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 62977004437 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 62977004438 ligand binding site [chemical binding]; other site 62977004439 flexible hinge region; other site 62977004440 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 62977004441 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 62977004442 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 62977004443 active site 62977004444 iron coordination sites [ion binding]; other site 62977004445 substrate binding pocket [chemical binding]; other site 62977004446 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 62977004447 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 62977004448 substrate binding pocket [chemical binding]; other site 62977004449 membrane-bound complex binding site; other site 62977004450 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 62977004451 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 62977004452 N-terminal plug; other site 62977004453 ligand-binding site [chemical binding]; other site 62977004454 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 62977004455 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 62977004456 active site 62977004457 non-prolyl cis peptide bond; other site 62977004458 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 62977004459 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 62977004460 active site 62977004461 catalytic tetrad [active] 62977004462 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 62977004463 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 62977004464 N-terminal plug; other site 62977004465 ligand-binding site [chemical binding]; other site 62977004466 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 62977004467 Sulfatase; Region: Sulfatase; pfam00884 62977004468 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 62977004469 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 62977004470 ligand binding site [chemical binding]; other site 62977004471 flexible hinge region; other site 62977004472 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 62977004473 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 62977004474 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 62977004475 active site 62977004476 iron coordination sites [ion binding]; other site 62977004477 substrate binding pocket [chemical binding]; other site 62977004478 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 62977004479 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 62977004480 Transcriptional regulator [Transcription]; Region: LysR; COG0583 62977004481 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 62977004482 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 62977004483 dimerization interface [polypeptide binding]; other site 62977004484 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 62977004485 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 62977004486 tetrameric interface [polypeptide binding]; other site 62977004487 NAD binding site [chemical binding]; other site 62977004488 catalytic residues [active] 62977004489 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 62977004490 3-hydroxyisobutyrate dehydrogenase; Region: HIBADH; TIGR01692 62977004491 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 62977004492 Domain of unknown function (DUF3448); Region: DUF3448; pfam11930 62977004493 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 62977004494 acyl-activating enzyme (AAE) consensus motif; other site 62977004495 AMP binding site [chemical binding]; other site 62977004496 active site 62977004497 CoA binding site [chemical binding]; other site 62977004498 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 62977004499 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 62977004500 active site 62977004501 enoyl-CoA hydratase; Provisional; Region: PRK05862 62977004502 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 62977004503 substrate binding site [chemical binding]; other site 62977004504 oxyanion hole (OAH) forming residues; other site 62977004505 trimer interface [polypeptide binding]; other site 62977004506 3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617 62977004507 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 62977004508 substrate binding site [chemical binding]; other site 62977004509 oxyanion hole (OAH) forming residues; other site 62977004510 trimer interface [polypeptide binding]; other site 62977004511 2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766 62977004512 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 62977004513 Helix-turn-helix domain; Region: HTH_18; pfam12833 62977004514 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 62977004515 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 62977004516 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 62977004517 acyl-activating enzyme (AAE) consensus motif; other site 62977004518 AMP binding site [chemical binding]; other site 62977004519 active site 62977004520 CoA binding site [chemical binding]; other site 62977004521 acetyl-CoA acetyltransferase; Provisional; Region: PRK06954 62977004522 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 62977004523 dimer interface [polypeptide binding]; other site 62977004524 active site 62977004525 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 62977004526 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 62977004527 active site 62977004528 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 62977004529 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 62977004530 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 62977004531 Nitrile hydratase beta subunit; Region: NHase_beta; pfam02211 62977004532 nitrile hydratase, beta subunit; Region: nitrile_beta; TIGR03888 62977004533 nitrile hydratase, alpha subunit; Region: nitrile_alph; TIGR01323 62977004534 Ribosomally synthesized peptide prototyped by Frankia Franean1_4349; Region: Frankia_peptide; pfam14407 62977004535 NHLP leader peptide domain; Region: TOMM_pelo; TIGR03793 62977004536 amidase; Provisional; Region: PRK07235 62977004537 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 62977004538 Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; pfam13557 62977004539 Haem-containing dehydratase; Region: Dehydratase_hem; pfam13816 62977004540 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 62977004541 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 62977004542 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 62977004543 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 62977004544 Walker A motif; other site 62977004545 ATP binding site [chemical binding]; other site 62977004546 Walker B motif; other site 62977004547 arginine finger; other site 62977004548 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 62977004549 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 62977004550 Bacterial lipocalin [Cell envelope biogenesis, outer membrane]; Region: Blc; COG3040 62977004551 Lipocalin-like domain; Region: Lipocalin_2; pfam08212 62977004552 Fatty acid desaturase; Region: FA_desaturase; pfam00487 62977004553 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 62977004554 Di-iron ligands [ion binding]; other site 62977004555 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 62977004556 Predicted NAD/FAD-binding protein [General function prediction only]; Region: COG2907 62977004557 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 62977004558 Protein of unknown function (DUF1365); Region: DUF1365; pfam07103 62977004559 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 62977004560 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 62977004561 S-adenosylmethionine binding site [chemical binding]; other site 62977004562 Protein of unknown function (DUF1295); Region: DUF1295; cl17837 62977004563 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 62977004564 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 62977004565 S-adenosylmethionine binding site [chemical binding]; other site 62977004566 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 62977004567 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 62977004568 dimer interface [polypeptide binding]; other site 62977004569 phosphorylation site [posttranslational modification] 62977004570 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 62977004571 ATP binding site [chemical binding]; other site 62977004572 Mg2+ binding site [ion binding]; other site 62977004573 G-X-G motif; other site 62977004574 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 62977004575 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 62977004576 active site 62977004577 phosphorylation site [posttranslational modification] 62977004578 intermolecular recognition site; other site 62977004579 dimerization interface [polypeptide binding]; other site 62977004580 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 62977004581 DNA binding site [nucleotide binding] 62977004582 SnoaL-like domain; Region: SnoaL_2; pfam12680 62977004583 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 62977004584 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 62977004585 Coenzyme A binding pocket [chemical binding]; other site 62977004586 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 62977004587 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 62977004588 non-specific DNA binding site [nucleotide binding]; other site 62977004589 salt bridge; other site 62977004590 sequence-specific DNA binding site [nucleotide binding]; other site 62977004591 YadA-like C-terminal region; Region: YadA; pfam03895 62977004592 SmpA / OmlA family; Region: SmpA_OmlA; pfam04355 62977004593 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 62977004594 ligand binding site [chemical binding]; other site 62977004595 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 62977004596 tRNA (uracil-5-)-methyltransferase; Validated; Region: PRK05031 62977004597 bifunctional proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: PRK11905 62977004598 Proline dehydrogenase; Region: Pro_dh; pfam01619 62977004599 Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125 62977004600 Glutamate binding site [chemical binding]; other site 62977004601 NAD binding site [chemical binding]; other site 62977004602 catalytic residues [active] 62977004603 leucine-responsive transcriptional regulator; Provisional; Region: PRK11169 62977004604 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 62977004605 putative DNA binding site [nucleotide binding]; other site 62977004606 putative Zn2+ binding site [ion binding]; other site 62977004607 AsnC family; Region: AsnC_trans_reg; pfam01037 62977004608 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 62977004609 Na binding site [ion binding]; other site 62977004610 NAD-dependent deacetylase; Provisional; Region: PRK00481 62977004611 SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412 62977004612 NAD+ binding site [chemical binding]; other site 62977004613 substrate binding site [chemical binding]; other site 62977004614 Zn binding site [ion binding]; other site 62977004615 alpha-ketoglutarate transporter; Provisional; Region: PRK10406 62977004616 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 62977004617 putative substrate translocation pore; other site 62977004618 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 62977004619 Predicted transcriptional regulators [Transcription]; Region: COG1695 62977004620 Transcriptional regulator PadR-like family; Region: PadR; cl17335 62977004621 Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400 62977004622 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 62977004623 2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930 62977004624 active site 62977004625 FMN binding site [chemical binding]; other site 62977004626 2,4-decadienoyl-CoA binding site; other site 62977004627 catalytic residue [active] 62977004628 4Fe-4S cluster binding site [ion binding]; other site 62977004629 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 62977004630 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 62977004631 Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; Region: COG0429 62977004632 LysR family transcriptional regulator; Provisional; Region: PRK14997 62977004633 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 62977004634 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_4; cd08473 62977004635 putative effector binding pocket; other site 62977004636 putative dimerization interface [polypeptide binding]; other site 62977004637 HD domain; Region: HD_4; pfam13328 62977004638 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 62977004639 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 62977004640 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 62977004641 dimerization interface [polypeptide binding]; other site 62977004642 Glutaryl-CoA dehydrogenase; Region: GCD; cd01151 62977004643 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 62977004644 FAD binding site [chemical binding]; other site 62977004645 substrate binding pocket [chemical binding]; other site 62977004646 catalytic base [active] 62977004647 Acetyltransferase (GNAT) domain; Region: Acetyltransf_9; pfam13527 62977004648 Coenzyme A binding pocket [chemical binding]; other site 62977004649 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 62977004650 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 62977004651 dimer interface [polypeptide binding]; other site 62977004652 pyridoxal 5'-phosphate binding site [chemical binding]; other site 62977004653 catalytic residue [active] 62977004654 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 62977004655 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 62977004656 N-acetyl-D-glucosamine binding site [chemical binding]; other site 62977004657 catalytic residue [active] 62977004658 Predicted CDP-diglyceride synthetase/phosphatidate cytidylyltransferase [General function prediction only]; Region: COG4589 62977004659 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 62977004660 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 62977004661 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 62977004662 putative acyl-acceptor binding pocket; other site 62977004663 PAP2_like proteins, Aur1_like subfamily. Yeast Aur1p or Ipc1p is necessary for the addition of inositol phosphate to ceramide, an essential step in yeast sphingolipid synthesis, and is the target of several antifungal compounds such as aureobasidin; Region: PAP2_Aur1_like; cd03386 62977004664 active site 62977004665 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 62977004666 active site 62977004667 catalytic residues [active] 62977004668 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 62977004669 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 62977004670 Putative methyltransferase; Region: Methyltransf_20; pfam12147 62977004671 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 62977004672 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 62977004673 putative deacylase active site [active] 62977004674 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cl11399 62977004675 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cl11399 62977004676 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 62977004677 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 62977004678 motif II; other site 62977004679 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 62977004680 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 62977004681 Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346 62977004682 LrgA family; Region: LrgA; pfam03788 62977004683 Transcriptional regulator [Transcription]; Region: LysR; COG0583 62977004684 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 62977004685 The C-terminal substrate binding domain of LysR-like transcriptional regulator CidR, contains the type 2 periplasmic binding fold; Region: PBP2_CidR; cd08438 62977004686 putative dimerization interface [polypeptide binding]; other site 62977004687 Domain of unknown function (DUF4341); Region: DUF4341; pfam14241 62977004688 Predicted transporter component [General function prediction only]; Region: COG2391 62977004689 Sulphur transport; Region: Sulf_transp; pfam04143 62977004690 Predicted transporter component [General function prediction only]; Region: COG2391 62977004691 Sulphur transport; Region: Sulf_transp; pfam04143 62977004692 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 62977004693 Domain of unknown function (DUF202); Region: DUF202; pfam02656 62977004694 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 62977004695 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 62977004696 Electron transfer flavoprotein-ubiquinone oxidoreductase; Region: ETF_QO; pfam05187 62977004697 benzoate transport; Region: 2A0115; TIGR00895 62977004698 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 62977004699 putative substrate translocation pore; other site 62977004700 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 62977004701 CoA-transferase family III; Region: CoA_transf_3; pfam02515 62977004702 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 62977004703 Transcriptional regulator [Transcription]; Region: IclR; COG1414 62977004704 Bacterial transcriptional regulator; Region: IclR; pfam01614 62977004705 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 62977004706 Major Facilitator Superfamily; Region: MFS_1; pfam07690 62977004707 putative substrate translocation pore; other site 62977004708 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 62977004709 CoA-transferase family III; Region: CoA_transf_3; pfam02515 62977004710 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 62977004711 Transcriptional regulator [Transcription]; Region: IclR; COG1414 62977004712 Bacterial transcriptional regulator; Region: IclR; pfam01614 62977004713 acetyl-CoA acetyltransferase; Provisional; Region: PRK08131 62977004714 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 62977004715 dimer interface [polypeptide binding]; other site 62977004716 active site 62977004717 3-hydroxy-acyl-CoA dehydrogenase; Validated; Region: PRK08268 62977004718 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 62977004719 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 62977004720 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 62977004721 3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826 62977004722 classical (c) SDRs; Region: SDR_c; cd05233 62977004723 NAD(P) binding site [chemical binding]; other site 62977004724 active site 62977004725 enoyl-CoA hydratase; Provisional; Region: PRK08138 62977004726 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 62977004727 substrate binding site [chemical binding]; other site 62977004728 oxyanion hole (OAH) forming residues; other site 62977004729 trimer interface [polypeptide binding]; other site 62977004730 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 62977004731 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 62977004732 active site 62977004733 benzoate transport; Region: 2A0115; TIGR00895 62977004734 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 62977004735 putative substrate translocation pore; other site 62977004736 3-oxoacid CoA-transferase, A subunit; Region: pcaI_scoA_fam; TIGR02429 62977004737 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 62977004738 Maltoporin periplasmic N-terminal extension; Region: Sugarporin_N; pfam11471 62977004739 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 62977004740 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 62977004741 putative substrate translocation pore; other site 62977004742 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 62977004743 CoenzymeA binding site [chemical binding]; other site 62977004744 subunit interaction site [polypeptide binding]; other site 62977004745 PHB binding site; other site 62977004746 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 62977004747 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 62977004748 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 62977004749 active site 62977004750 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 62977004751 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762 62977004752 beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Region: pcaR_pcaU; TIGR02431 62977004753 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 62977004754 Bacterial transcriptional regulator; Region: IclR; pfam01614 62977004755 3-oxoacid CoA-transferase, A subunit; Region: pcaI_scoA_fam; TIGR02429 62977004756 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 62977004757 beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050 62977004758 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 62977004759 dimer interface [polypeptide binding]; other site 62977004760 active site 62977004761 3-carboxy-cis,cis-muconate cycloisomerase; Provisional; Region: PRK09053 62977004762 prokaryotic 3-carboxy-cis,cis-muconate cycloisomerase (CMLE)_like; Region: pCLME; cd01597 62977004763 tetramer interface [polypeptide binding]; other site 62977004764 active site 62977004765 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 62977004766 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 62977004767 benzoate transport; Region: 2A0115; TIGR00895 62977004768 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 62977004769 putative substrate translocation pore; other site 62977004770 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 62977004771 putative substrate translocation pore; other site 62977004772 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 62977004773 Protocatechuate 3,4-dioxygenase (3,4-PCD) , beta subunit. 3,4-PCD catalyzes the oxidative ring cleavage of 3,4-dihydroxybenzoate to produce beta-carboxy-cis,cis-muconate. 3,4-PCDs are large aggregates of 12 protomers, each composed of an alpha- and...; Region: 3,4-PCD_beta; cd03464 62977004774 heterodimer interface [polypeptide binding]; other site 62977004775 multimer interface [polypeptide binding]; other site 62977004776 protocatechuate 3,4-dioxygenase, beta subunit; Region: protocat_beta; TIGR02422 62977004777 active site 62977004778 Protocatechuate 3,4-dioxygenase beta subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PcaH; COG3485 62977004779 Protocatechuate 3,4-dioxygenase (3,4-PCD) , alpha subunit. 3,4-PCD catalyzes the oxidative ring cleavage of 3,4-dihydroxybenzoate to produce beta-carboxy-cis,cis-muconate. 3,4-PCDs are large aggregates of 12 protomers, each composed of an alpha- and...; Region: 3,4-PCD_alpha; cd03463 62977004780 heterodimer interface [polypeptide binding]; other site 62977004781 active site 62977004782 Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502 62977004783 3-dehydroquinate dehydratase [Amino acid transport and metabolism]; Region: AroD; COG0710 62977004784 active site 62977004785 catalytic residue [active] 62977004786 dimer interface [polypeptide binding]; other site 62977004787 Right handed beta helix region; Region: Beta_helix; pfam13229 62977004788 Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966 62977004789 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 62977004790 membrane-bound PQQ-dependent dehydrogenase, glucose/quinate/shikimate family; Region: PQQ_membr_DH; TIGR03074 62977004791 Membrane-bound PQQ-dependent glucose dehydrogenase; Region: PQQ_mGDH; cd10280 62977004792 Trp docking motif [polypeptide binding]; other site 62977004793 putative active site [active] 62977004794 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 62977004795 Sel1-like repeats; Region: SEL1; smart00671 62977004796 Sel1-like repeats; Region: SEL1; smart00671 62977004797 Sel1-like repeats; Region: SEL1; smart00671 62977004798 beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Region: pcaR_pcaU; TIGR02431 62977004799 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 62977004800 Bacterial transcriptional regulator; Region: IclR; pfam01614 62977004801 4-hydroxybenzoate 3-monooxygenase; Validated; Region: PRK08243 62977004802 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 62977004803 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 62977004804 Tannase and feruloyl esterase; Region: Tannase; pfam07519 62977004805 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 62977004806 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 62977004807 CoenzymeA binding site [chemical binding]; other site 62977004808 subunit interaction site [polypeptide binding]; other site 62977004809 PHB binding site; other site 62977004810 outer membrane porin, OprD family; Region: OprD; pfam03573 62977004811 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 62977004812 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 62977004813 active site 62977004814 feruloyl-CoA synthase; Reviewed; Region: PRK08180 62977004815 Feruloyl-CoA synthetase (FCS); Region: FCS; cd05921 62977004816 acyl-activating enzyme (AAE) consensus motif; other site 62977004817 putative AMP binding site [chemical binding]; other site 62977004818 putative active site [active] 62977004819 putative CoA binding site [chemical binding]; other site 62977004820 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 62977004821 Salicylaldehyde dehydrogenase, DoxF-like; Region: ALDH_SaliADH; cd07105 62977004822 NAD(P) binding site [chemical binding]; other site 62977004823 catalytic residues [active] 62977004824 p-hydroxycinnamoyl CoA hydratase/lyase; Validated; Region: PRK09120 62977004825 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 62977004826 substrate binding site [chemical binding]; other site 62977004827 oxyanion hole (OAH) forming residues; other site 62977004828 trimer interface [polypeptide binding]; other site 62977004829 putative 3-hydroxyphenylpropionic transporter MhpT; Provisional; Region: PRK11551 62977004830 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 62977004831 putative substrate translocation pore; other site 62977004832 MarR family; Region: MarR_2; cl17246 62977004833 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 62977004834 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 62977004835 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 62977004836 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687 62977004837 Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118 62977004838 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 62977004839 classical (c) SDRs; Region: SDR_c; cd05233 62977004840 NAD(P) binding site [chemical binding]; other site 62977004841 active site 62977004842 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 62977004843 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 62977004844 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 62977004845 Leucine carboxyl methyltransferase; Region: LCM; pfam04072 62977004846 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 62977004847 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 62977004848 ATP-grasp domain; Region: ATP-grasp_4; cl17255 62977004849 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 62977004850 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 62977004851 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 62977004852 carboxyltransferase (CT) interaction site; other site 62977004853 biotinylation site [posttranslational modification]; other site 62977004854 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 62977004855 Dehydroquinase class II; Region: DHquinase_II; pfam01220 62977004856 trimer interface [polypeptide binding]; other site 62977004857 active site 62977004858 dimer interface [polypeptide binding]; other site 62977004859 putative GTP cyclohydrolase; Provisional; Region: PRK13674 62977004860 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 62977004861 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 62977004862 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 62977004863 Peptidase M15; Region: Peptidase_M15_3; cl01194 62977004864 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 62977004865 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 62977004866 NAD(P) binding site [chemical binding]; other site 62977004867 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 62977004868 Aspartase; Region: Aspartase; cd01357 62977004869 active sites [active] 62977004870 tetramer interface [polypeptide binding]; other site 62977004871 cell density-dependent motility repressor; Provisional; Region: PRK10082 62977004872 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 62977004873 dimerization interface [polypeptide binding]; other site 62977004874 LysR substrate binding domain; Region: LysR_substrate; pfam03466 62977004875 Transcriptional regulators [Transcription]; Region: MarR; COG1846 62977004876 MarR family; Region: MarR_2; pfam12802 62977004877 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 62977004878 salt bridge; other site 62977004879 non-specific DNA binding site [nucleotide binding]; other site 62977004880 sequence-specific DNA binding site [nucleotide binding]; other site 62977004881 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 62977004882 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 62977004883 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 62977004884 malonate decarboxylase, alpha subunit; Region: mdcA; TIGR01110 62977004885 triphosphoribosyl-dephospho-CoA synthase; Validated; Region: PRK01237 62977004886 malonate decarboxylase subunit delta; Provisional; Region: PRK01220 62977004887 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189 62977004888 malonate decarboxylase, gamma subunit; Region: malonate_gamma; TIGR03134 62977004889 phosphoribosyl-dephospho-CoA transferase; Provisional; Region: PRK01293 62977004890 Phosphoribosyl-dephospho-CoA transferase MdcG; Region: MdcG; pfam10620 62977004891 malonate decarboxylase, epsilon subunit; Region: malonate_mdcH; TIGR03131 62977004892 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 62977004893 Malonate transporter MadL subunit; Region: MadL; cl04273 62977004894 Malonate/sodium symporter MadM subunit; Region: MadM; cl04274 62977004895 Transcriptional regulator [Transcription]; Region: LysR; COG0583 62977004896 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 62977004897 The C-terminal substrate-binding domian of LysR-type transcriptional regulator MdcR, which involved in the malonate catabolism contains the type 2 periplasmic binding fold; Region: PBP2_MdcR; cd08416 62977004898 putative dimerization interface [polypeptide binding]; other site 62977004899 serine O-acetyltransferase; Region: cysE; TIGR01172 62977004900 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 62977004901 trimer interface [polypeptide binding]; other site 62977004902 active site 62977004903 substrate binding site [chemical binding]; other site 62977004904 CoA binding site [chemical binding]; other site 62977004905 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 62977004906 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 62977004907 N-terminal plug; other site 62977004908 ligand-binding site [chemical binding]; other site 62977004909 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 62977004910 Periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); Region: PBP1_FmdD_like; cd06355 62977004911 putative ligand binding site [chemical binding]; other site 62977004912 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 62977004913 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 62977004914 TM-ABC transporter signature motif; other site 62977004915 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 62977004916 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 62977004917 TM-ABC transporter signature motif; other site 62977004918 urea ABC transporter, ATP-binding protein UrtD; Region: urea_trans_UrtD; TIGR03411 62977004919 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 62977004920 Walker A/P-loop; other site 62977004921 ATP binding site [chemical binding]; other site 62977004922 Q-loop/lid; other site 62977004923 ABC transporter signature motif; other site 62977004924 Walker B; other site 62977004925 D-loop; other site 62977004926 H-loop/switch region; other site 62977004927 urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410 62977004928 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 62977004929 Walker A/P-loop; other site 62977004930 ATP binding site [chemical binding]; other site 62977004931 Q-loop/lid; other site 62977004932 ABC transporter signature motif; other site 62977004933 Walker B; other site 62977004934 D-loop; other site 62977004935 H-loop/switch region; other site 62977004936 META domain; Region: META; pfam03724 62977004937 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 62977004938 Major Facilitator Superfamily; Region: MFS_1; pfam07690 62977004939 alpha,alpha-trehalose-phosphate synthase [UDP-forming]; Region: trehalose_OtsA; TIGR02400 62977004940 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 62977004941 active site 62977004942 homotetramer interface [polypeptide binding]; other site 62977004943 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 62977004944 Trehalose-phosphatase; Region: Trehalose_PPase; pfam02358 62977004945 active site 62977004946 motif I; other site 62977004947 motif II; other site 62977004948 Uncharacterized stress protein (general stress protein 26) [General function prediction only]; Region: COG3871 62977004949 RNA polymerase sigma factor; Provisional; Region: PRK12528 62977004950 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 62977004951 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 62977004952 DNA binding residues [nucleotide binding] 62977004953 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 62977004954 FecR protein; Region: FecR; pfam04773 62977004955 Secretin and TonB N terminus short domain; Region: STN; smart00965 62977004956 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 62977004957 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 62977004958 N-terminal plug; other site 62977004959 ligand-binding site [chemical binding]; other site 62977004960 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 62977004961 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 62977004962 polyphosphate kinase; Provisional; Region: PRK05443 62977004963 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 62977004964 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 62977004965 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 62977004966 putative domain interface [polypeptide binding]; other site 62977004967 putative active site [active] 62977004968 catalytic site [active] 62977004969 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 62977004970 putative domain interface [polypeptide binding]; other site 62977004971 putative active site [active] 62977004972 catalytic site [active] 62977004973 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cl00246 62977004974 FAD binding site [chemical binding]; other site 62977004975 Methylene-tetrahydrofolate reductase C terminal; Region: MTHFR_C; pfam12225 62977004976 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 62977004977 DNA-binding site [nucleotide binding]; DNA binding site 62977004978 RNA-binding motif; other site 62977004979 Uncharacterized protein conserved in bacteria [Function unknown]; Region: VgrG; COG3501 62977004980 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 62977004981 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 62977004982 Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296 62977004983 Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; pfam10106 62977004984 Domain of unknown function (DUF4123); Region: DUF4123; pfam13503 62977004985 putative transposase OrfB; Reviewed; Region: PHA02517 62977004986 HTH-like domain; Region: HTH_21; pfam13276 62977004987 Integrase core domain; Region: rve; pfam00665 62977004988 Integrase core domain; Region: rve_2; pfam13333 62977004989 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 62977004990 Transposase; Region: HTH_Tnp_1; pfam01527 62977004991 Acyltransferase family; Region: Acyl_transf_3; pfam01757 62977004992 Fucose 4-O-acetylase and related acetyltransferases [Carbohydrate transport and metabolism]; Region: NolL; COG3594 62977004993 Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226 62977004994 Toxin module HipA, protein kinase of phosphatidylinositol 3/4-kinase superfamily [General function prediction only]; Region: HipA; COG3550 62977004995 HipA-like N-terminal domain; Region: HipA_N; pfam07805 62977004996 HipA-like C-terminal domain; Region: HipA_C; pfam07804 62977004997 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 62977004998 non-specific DNA binding site [nucleotide binding]; other site 62977004999 salt bridge; other site 62977005000 sequence-specific DNA binding site [nucleotide binding]; other site 62977005001 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 62977005002 Major Facilitator Superfamily; Region: MFS_1; pfam07690 62977005003 putative substrate translocation pore; other site 62977005004 2,3-dihydroxybiphenyl 1,2-dioxygenase; Region: 23dbph12diox; TIGR03213 62977005005 C-terminal domain of Burkholderia sp. NF100 MhqB and similar proteins; MhqB is a type I extradiol dioxygenase involved in the catabolism of methylhydroquinone, an intermediate in the degradation of fenitrothion; Region: MhqB_like_C; cd08360 62977005006 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 62977005007 putative active site [active] 62977005008 putative metal binding site [ion binding]; other site 62977005009 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 62977005010 iron-sulfur cluster [ion binding]; other site 62977005011 [2Fe-2S] cluster binding site [ion binding]; other site 62977005012 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 62977005013 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 62977005014 hypothetical protein; Provisional; Region: PRK06847 62977005015 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 62977005016 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 62977005017 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 62977005018 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 62977005019 non-specific DNA interactions [nucleotide binding]; other site 62977005020 DNA binding site [nucleotide binding] 62977005021 sequence specific DNA binding site [nucleotide binding]; other site 62977005022 putative cAMP binding site [chemical binding]; other site 62977005023 Putative cyclase; Region: Cyclase; pfam04199 62977005024 Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; pfam13557 62977005025 Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; cl01768 62977005026 Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; pfam13557 62977005027 benzoate transport; Region: 2A0115; TIGR00895 62977005028 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 62977005029 putative substrate translocation pore; other site 62977005030 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 62977005031 SnoaL-like domain; Region: SnoaL_4; pfam13577 62977005032 Helix-turn-helix domain; Region: HTH_18; pfam12833 62977005033 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07008 62977005034 Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles; Region: ttLC_FACS_AlkK_like; cd12119 62977005035 dimer interface [polypeptide binding]; other site 62977005036 acyl-activating enzyme (AAE) consensus motif; other site 62977005037 putative active site [active] 62977005038 AMP binding site [chemical binding]; other site 62977005039 putative CoA binding site [chemical binding]; other site 62977005040 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 62977005041 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 62977005042 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 62977005043 active site 62977005044 enoyl-CoA hydratase; Provisional; Region: PRK06495 62977005045 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 62977005046 substrate binding site [chemical binding]; other site 62977005047 oxyanion hole (OAH) forming residues; other site 62977005048 trimer interface [polypeptide binding]; other site 62977005049 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 62977005050 pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204 62977005051 active site 62977005052 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 62977005053 Transcriptional regulator [Transcription]; Region: IclR; COG1414 62977005054 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 62977005055 classical (c) SDRs; Region: SDR_c; cd05233 62977005056 NAD(P) binding site [chemical binding]; other site 62977005057 active site 62977005058 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 62977005059 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 62977005060 CoA binding domain; Region: CoA_binding_2; pfam13380 62977005061 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 62977005062 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 62977005063 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 62977005064 short chain dehydrogenase; Validated; Region: PRK06484 62977005065 classical (c) SDRs; Region: SDR_c; cd05233 62977005066 NAD(P) binding site [chemical binding]; other site 62977005067 active site 62977005068 classical (c) SDRs; Region: SDR_c; cd05233 62977005069 NAD(P) binding site [chemical binding]; other site 62977005070 active site 62977005071 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 62977005072 enoyl-CoA hydratase; Provisional; Region: PRK08140 62977005073 substrate binding site [chemical binding]; other site 62977005074 oxyanion hole (OAH) forming residues; other site 62977005075 trimer interface [polypeptide binding]; other site 62977005076 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 62977005077 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 62977005078 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 62977005079 Zn2+ binding site [ion binding]; other site 62977005080 Mg2+ binding site [ion binding]; other site 62977005081 Uncharacterized conserved protein (DUF2132); Region: DUF2132; pfam09905 62977005082 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 62977005083 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 62977005084 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 62977005085 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 62977005086 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 62977005087 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 62977005088 Old yellow enzyme (OYE)-related FMN binding domain, group 4. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_4_FMN; cd04735 62977005089 putative active site [active] 62977005090 putative FMN binding site [chemical binding]; other site 62977005091 putative substrate binding site [chemical binding]; other site 62977005092 putative catalytic residue [active] 62977005093 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 62977005094 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 62977005095 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 62977005096 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 62977005097 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 62977005098 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 62977005099 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 62977005100 Replication initiation factor; Region: Rep_trans; pfam02486 62977005101 Zonular occludens toxin (Zot); Region: Zot; cl17485 62977005102 Protein of unknown function (DUF2523); Region: DUF2523; pfam10734 62977005103 Replication initiation factor; Region: Rep_trans; pfam02486 62977005104 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 62977005105 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 62977005106 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 62977005107 dimerization interface [polypeptide binding]; other site 62977005108 putative DNA binding site [nucleotide binding]; other site 62977005109 putative Zn2+ binding site [ion binding]; other site 62977005110 serine/threonine transporter SstT; Provisional; Region: PRK13628 62977005111 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 62977005112 Protein of unknown function (DUF1275); Region: DUF1275; pfam06912 62977005113 Uncharacterized protein conserved in bacteria (DUF2058); Region: DUF2058; pfam09831 62977005114 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 62977005115 Mechanosensitive ion channel; Region: MS_channel; pfam00924 62977005116 putative 3-phenylpropionic acid transporter; Provisional; Region: PRK11128 62977005117 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 62977005118 putative substrate translocation pore; other site 62977005119 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 62977005120 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 62977005121 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 62977005122 Walker A/P-loop; other site 62977005123 ATP binding site [chemical binding]; other site 62977005124 Q-loop/lid; other site 62977005125 ABC transporter signature motif; other site 62977005126 Walker B; other site 62977005127 D-loop; other site 62977005128 H-loop/switch region; other site 62977005129 YdeM is a Bacillus subtilis protein that belongs to a family of prokaryotic proteins of unkown function. YdeM has sequence similarity to the hot-dog fold of (R)-specific enoyl-CoA hydratase. Other enzymes with this fold include the peroxisomal...; Region: YdeM; cd03454 62977005130 putative active site [active] 62977005131 putative catalytic site [active] 62977005132 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 62977005133 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 62977005134 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 62977005135 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 62977005136 lipoyl attachment site [posttranslational modification]; other site 62977005137 phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12755 62977005138 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 62977005139 class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300 62977005140 S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase; Region: adh_III_F_hyde; TIGR02818 62977005141 substrate binding site [chemical binding]; other site 62977005142 catalytic Zn binding site [ion binding]; other site 62977005143 NAD binding site [chemical binding]; other site 62977005144 structural Zn binding site [ion binding]; other site 62977005145 dimer interface [polypeptide binding]; other site 62977005146 Transcriptional regulators RcnR and FrmR, and related domains; this domain family was previously known as part of DUF156; Region: RcnR-FrmR-like_DUF156; cd10153 62977005147 putative homodimer interface [polypeptide binding]; other site 62977005148 putative homotetramer interface [polypeptide binding]; other site 62977005149 putative metal binding site [ion binding]; other site 62977005150 putative homodimer-homodimer interface [polypeptide binding]; other site 62977005151 putative allosteric switch controlling residues; other site 62977005152 Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502 62977005153 Putative catalytic domain, repeat 1, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_1; cd09111 62977005154 putative active site [active] 62977005155 catalytic site [active] 62977005156 Putative catalytic domain, repeat 2, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_2; cd09113 62977005157 putative active site [active] 62977005158 catalytic site [active] 62977005159 MUG-like Uracil-DNA glycosylase enzyme family; Region: UDG_MUG_like; cd10032 62977005160 putative active site [active] 62977005161 short chain dehydrogenase; Provisional; Region: PRK08251 62977005162 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 62977005163 NAD(P) binding site [chemical binding]; other site 62977005164 active site 62977005165 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 62977005166 catalytic core [active] 62977005167 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 62977005168 putative active site [active] 62977005169 putative substrate binding site [chemical binding]; other site 62977005170 ATP binding site [chemical binding]; other site 62977005171 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 62977005172 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 62977005173 active site 62977005174 Transcriptional regulator [Transcription]; Region: LysR; COG0583 62977005175 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 62977005176 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 62977005177 substrate binding pocket [chemical binding]; other site 62977005178 dimerization interface [polypeptide binding]; other site 62977005179 Nitroreductase-like family 4. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_4; cd02140 62977005180 dimer interface [polypeptide binding]; other site 62977005181 FMN binding site [chemical binding]; other site 62977005182 fumarate hydratase; Reviewed; Region: fumC; PRK00485 62977005183 Class II fumarases; Region: Fumarase_classII; cd01362 62977005184 active site 62977005185 tetramer interface [polypeptide binding]; other site 62977005186 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 62977005187 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 62977005188 NAD(P) binding site [chemical binding]; other site 62977005189 active site 62977005190 sulfur relay protein TusD/DsrE; Region: sulf_tusD_dsrE; TIGR03012 62977005191 DsrC like protein; Region: DsrC; pfam04358 62977005192 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 62977005193 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 62977005194 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 62977005195 DNA-binding site [nucleotide binding]; DNA binding site 62977005196 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 62977005197 pyridoxal 5'-phosphate binding site [chemical binding]; other site 62977005198 homodimer interface [polypeptide binding]; other site 62977005199 catalytic residue [active] 62977005200 ATP-binding cassette domain of the molybdenum transport system; Region: ABC_ModC_molybdenum_transporter; cd03297 62977005201 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 62977005202 Walker A/P-loop; other site 62977005203 ATP binding site [chemical binding]; other site 62977005204 Q-loop/lid; other site 62977005205 ABC transporter signature motif; other site 62977005206 Walker B; other site 62977005207 D-loop; other site 62977005208 H-loop/switch region; other site 62977005209 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 62977005210 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 62977005211 dimer interface [polypeptide binding]; other site 62977005212 conserved gate region; other site 62977005213 putative PBP binding loops; other site 62977005214 ABC-ATPase subunit interface; other site 62977005215 molybdate transporter periplasmic protein; Provisional; Region: modA; PRK10677 62977005216 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 62977005217 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 62977005218 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 62977005219 dimer interface [polypeptide binding]; other site 62977005220 putative functional site; other site 62977005221 putative MPT binding site; other site 62977005222 bifunctional molybdenum cofactor biosynthesis protein MoaC/MogA; Provisional; Region: moaC; PRK03604 62977005223 MoaC family. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine derivative to the precursor...; Region: MoaC; cl00242 62977005224 trimer interface [polypeptide binding]; other site 62977005225 dimer interface [polypeptide binding]; other site 62977005226 putative active site [active] 62977005227 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 62977005228 MPT binding site; other site 62977005229 trimer interface [polypeptide binding]; other site 62977005230 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 62977005231 MoaE homodimer interface [polypeptide binding]; other site 62977005232 MoaD interaction [polypeptide binding]; other site 62977005233 active site residues [active] 62977005234 Ubiquitin-like proteins; Region: UBQ; cl00155 62977005235 charged pocket; other site 62977005236 hydrophobic patch; other site 62977005237 molybdenum cofactor biosynthesis protein A, bacterial; Region: moaA; TIGR02666 62977005238 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 62977005239 FeS/SAM binding site; other site 62977005240 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 62977005241 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 62977005242 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 62977005243 GTP binding site; other site 62977005244 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 62977005245 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 62977005246 [4Fe-4S] binding site [ion binding]; other site 62977005247 molybdopterin cofactor binding site; other site 62977005248 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 62977005249 molybdopterin cofactor binding site; other site 62977005250 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 62977005251 Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529 62977005252 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 62977005253 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 62977005254 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 62977005255 nitrite reductase subunit NirD; Provisional; Region: PRK14989 62977005256 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 62977005257 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 62977005258 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 62977005259 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 62977005260 nitrite extrusion protein (nitrite facilitator); Region: 2A0108; TIGR00886 62977005261 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 62977005262 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 62977005263 active site 62977005264 phosphorylation site [posttranslational modification] 62977005265 intermolecular recognition site; other site 62977005266 dimerization interface [polypeptide binding]; other site 62977005267 ANTAR domain; Region: ANTAR; pfam03861 62977005268 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 62977005269 NMT1-like family; Region: NMT1_2; pfam13379 62977005270 oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701 62977005271 The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767 62977005272 putative molybdopterin cofactor binding site [chemical binding]; other site 62977005273 The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787 62977005274 putative molybdopterin cofactor binding site; other site 62977005275 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 62977005276 Lecithin retinol acyltransferase; Region: LRAT; pfam04970 62977005277 glutaminyl-tRNA synthetase; Provisional; Region: PRK05347 62977005278 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 62977005279 active site 62977005280 HIGH motif; other site 62977005281 nucleotide binding site [chemical binding]; other site 62977005282 catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807 62977005283 KMSKS motif; other site 62977005284 tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950 62977005285 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 62977005286 substrate binding site [chemical binding]; other site 62977005287 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 62977005288 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 62977005289 putative active site [active] 62977005290 putative metal binding site [ion binding]; other site 62977005291 NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149 62977005292 dimer interface [polypeptide binding]; other site 62977005293 FMN binding site [chemical binding]; other site 62977005294 Putative glucose uptake permease [Carbohydrate transport and metabolism]; Region: GlcU; COG4975 62977005295 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 62977005296 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 62977005297 intersubunit interface [polypeptide binding]; other site 62977005298 active site 62977005299 zinc binding site [ion binding]; other site 62977005300 Na+ binding site [ion binding]; other site 62977005301 phosphoglycerate kinase; Provisional; Region: pgk; PRK00073 62977005302 Phosphoglycerate kinase; Region: PGK; pfam00162 62977005303 substrate binding site [chemical binding]; other site 62977005304 hinge regions; other site 62977005305 ADP binding site [chemical binding]; other site 62977005306 catalytic site [active] 62977005307 Uncharacterized protein conserved in bacteria (DUF2237); Region: DUF2237; pfam09996 62977005308 Maf-like protein; Region: Maf; pfam02545 62977005309 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 62977005310 active site 62977005311 dimer interface [polypeptide binding]; other site 62977005312 H+/citrate symporter [Energy production and conversion]; Region: CitM; COG2851 62977005313 Citrate transporter; Region: CitMHS; pfam03600 62977005314 Cupin superfamily protein; Region: Cupin_4; pfam08007 62977005315 Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069 62977005316 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 62977005317 active site 62977005318 FMN binding site [chemical binding]; other site 62977005319 substrate binding site [chemical binding]; other site 62977005320 3Fe-4S cluster binding site [ion binding]; other site 62977005321 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 62977005322 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 62977005323 Walker A motif; other site 62977005324 ATP binding site [chemical binding]; other site 62977005325 Walker B motif; other site 62977005326 arginine finger; other site 62977005327 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 62977005328 Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; pfam13557 62977005329 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 62977005330 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 62977005331 Walker A/P-loop; other site 62977005332 ATP binding site [chemical binding]; other site 62977005333 Q-loop/lid; other site 62977005334 ABC transporter signature motif; other site 62977005335 Walker B; other site 62977005336 D-loop; other site 62977005337 H-loop/switch region; other site 62977005338 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_1; cd06334 62977005339 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 62977005340 putative ligand binding site [chemical binding]; other site 62977005341 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 62977005342 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 62977005343 TM-ABC transporter signature motif; other site 62977005344 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 62977005345 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 62977005346 TM-ABC transporter signature motif; other site 62977005347 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 62977005348 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 62977005349 Walker A/P-loop; other site 62977005350 ATP binding site [chemical binding]; other site 62977005351 Q-loop/lid; other site 62977005352 ABC transporter signature motif; other site 62977005353 Walker B; other site 62977005354 D-loop; other site 62977005355 H-loop/switch region; other site 62977005356 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 62977005357 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 62977005358 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 62977005359 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 62977005360 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 62977005361 putative active site [active] 62977005362 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK00046 62977005363 FAD binding domain; Region: FAD_binding_4; pfam01565 62977005364 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 62977005365 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 62977005366 Low molecular weight phosphatase family; Region: LMWPc; cd00115 62977005367 active site 62977005368 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 62977005369 DNA-binding site [nucleotide binding]; DNA binding site 62977005370 RNA-binding motif; other site 62977005371 5-hydroxyvalerate dehydrogenase (HVD) catalyzes the oxidation of 5-hydroxyvalerate to 5-oxovalerate with NAD+ as cofactor; Region: HVD; cd08193 62977005372 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 62977005373 putative active site [active] 62977005374 metal binding site [ion binding]; metal-binding site 62977005375 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 62977005376 active site 62977005377 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 62977005378 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 62977005379 putative metal binding site [ion binding]; other site 62977005380 Mitochondrial biogenesis AIM24; Region: AIM24; pfam01987 62977005381 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 62977005382 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 62977005383 putative metal binding site [ion binding]; other site 62977005384 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 62977005385 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 62977005386 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 62977005387 putative metal binding site [ion binding]; other site 62977005388 hypothetical protein; Provisional; Region: PRK14013 62977005389 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 62977005390 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 62977005391 putative metal binding site [ion binding]; other site 62977005392 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 62977005393 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 62977005394 putative metal binding site [ion binding]; other site 62977005395 Uncharacterized protein involved in stress response [General function prediction only]; Region: COG4110 62977005396 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 62977005397 putative metal binding site [ion binding]; other site 62977005398 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 62977005399 Protein of unknown function (DUF2983); Region: DUF2983; pfam11202 62977005400 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 62977005401 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 62977005402 active site 62977005403 Protein of unknown function (DUF3706); Region: DUF3706; pfam12500 62977005404 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 62977005405 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 62977005406 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 62977005407 substrate binding site [chemical binding]; other site 62977005408 activation loop (A-loop); other site 62977005409 Protein phosphatase 2C; Region: PP2C_2; pfam13672 62977005410 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 62977005411 metal ion-dependent adhesion site (MIDAS); other site 62977005412 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 62977005413 metal ion-dependent adhesion site (MIDAS); other site 62977005414 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 62977005415 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 62977005416 putative metal binding site [ion binding]; other site 62977005417 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 62977005418 metal ion-dependent adhesion site (MIDAS); other site 62977005419 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14960 62977005420 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 62977005421 Walker A motif; other site 62977005422 ATP binding site [chemical binding]; other site 62977005423 Walker B motif; other site 62977005424 arginine finger; other site 62977005425 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 62977005426 methyl viologen resistance protein SmvA; Provisional; Region: PRK14995 62977005427 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 62977005428 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 62977005429 TetR family transcriptional regulator; Provisional; Region: PRK14996 62977005430 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 62977005431 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 62977005432 Beta-lactamase; Region: Beta-lactamase; pfam00144 62977005433 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 62977005434 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08261 62977005435 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 62977005436 NAD(P) binding site [chemical binding]; other site 62977005437 active site 62977005438 acetyl-CoA acetyltransferase; Provisional; Region: PRK09268 62977005439 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 62977005440 dimer interface [polypeptide binding]; other site 62977005441 active site 62977005442 Bacterial Transmembrane Pair family; Region: BTP; pfam05232 62977005443 Bacterial Transmembrane Pair family; Region: BTP; pfam05232 62977005444 Transcriptional regulator [Transcription]; Region: LysR; COG0583 62977005445 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 62977005446 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 62977005447 dimerization interface [polypeptide binding]; other site 62977005448 transaldolase-like protein; Provisional; Region: PTZ00411 62977005449 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 62977005450 active site 62977005451 dimer interface [polypeptide binding]; other site 62977005452 catalytic residue [active] 62977005453 leucine export protein LeuE; Provisional; Region: PRK10958 62977005454 Benzoate membrane transport protein; Region: BenE; pfam03594 62977005455 benzoate transporter; Region: benE; TIGR00843 62977005456 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 62977005457 MgtC family; Region: MgtC; pfam02308 62977005458 magnesium-transporting ATPase MgtA; Provisional; Region: PRK10517 62977005459 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 62977005460 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 62977005461 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 62977005462 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 62977005463 motif II; other site 62977005464 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 62977005465 RDD family; Region: RDD; pfam06271 62977005466 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 62977005467 active site 62977005468 Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547 62977005469 bifunctional PTS system fructose-specific transporter subunit IIA/HPr protein; Provisional; Region: PRK11109 62977005470 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 62977005471 active site 62977005472 phosphorylation site [posttranslational modification] 62977005473 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 62977005474 dimerization domain swap beta strand [polypeptide binding]; other site 62977005475 regulatory protein interface [polypeptide binding]; other site 62977005476 active site 62977005477 regulatory phosphorylation site [posttranslational modification]; other site 62977005478 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 62977005479 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 62977005480 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 62977005481 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 62977005482 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 62977005483 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 62977005484 putative substrate binding site [chemical binding]; other site 62977005485 putative ATP binding site [chemical binding]; other site 62977005486 PTS system fructose-specific transporter subunits IIBC; Provisional; Region: PRK10712 62977005487 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 62977005488 active site 62977005489 P-loop; other site 62977005490 phosphorylation site [posttranslational modification] 62977005491 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 62977005492 Putative phosphatase (DUF442); Region: DUF442; cl17385 62977005493 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 62977005494 homotrimer interaction site [polypeptide binding]; other site 62977005495 zinc binding site [ion binding]; other site 62977005496 CDP-binding sites; other site 62977005497 D-amino acid dehydrogenase small subunit; Provisional; Region: PRK12409 62977005498 hydroxyglutarate oxidase; Provisional; Region: PRK11728 62977005499 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 62977005500 substrate binding site; other site 62977005501 dimer interface; other site 62977005502 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 62977005503 Septum formation initiator; Region: DivIC; cl17659 62977005504 enolase; Provisional; Region: eno; PRK00077 62977005505 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 62977005506 dimer interface [polypeptide binding]; other site 62977005507 metal binding site [ion binding]; metal-binding site 62977005508 substrate binding pocket [chemical binding]; other site 62977005509 2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198 62977005510 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 62977005511 CTP synthetase; Validated; Region: pyrG; PRK05380 62977005512 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 62977005513 Catalytic site [active] 62977005514 active site 62977005515 UTP binding site [chemical binding]; other site 62977005516 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 62977005517 active site 62977005518 putative oxyanion hole; other site 62977005519 catalytic triad [active] 62977005520 Protein of unknown function (DUF3897); Region: DUF3897; cl17494 62977005521 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 62977005522 Ligand Binding Site [chemical binding]; other site 62977005523 Domain of unknown function (DUF333); Region: DUF333; pfam03891 62977005524 Putative hemolysin [General function prediction only]; Region: Hlx; COG3042 62977005525 Peptidase inhibitor I78 family; Region: Inhibitor_I78; pfam11720 62977005526 aminopeptidase N; Provisional; Region: pepN; PRK14015 62977005527 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_1; cd09600 62977005528 active site 62977005529 Zn binding site [ion binding]; other site 62977005530 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 62977005531 substrate binding site [chemical binding]; other site 62977005532 multimerization interface [polypeptide binding]; other site 62977005533 ATP binding site [chemical binding]; other site 62977005534 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 62977005535 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 62977005536 DNA gyrase inhibitor [DNA replication, recombination, and repair]; Region: COG3449 62977005537 5-carboxymethyl-2-hydroxymuconate isomerase (CHMI) is a trimeric enzyme catalyzing the isomerization of the unsaturated ketone 5-(carboxymethyl)-2-hydroxymuconate to 5-(carboxymethyl)-2-oxo-3-hexene-1,6-dionate. This is one step in the...; Region: CHMI; cd00580 62977005538 putative substrate binding pocket [chemical binding]; other site 62977005539 trimer interface [polypeptide binding]; other site 62977005540 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 62977005541 PIF1-like helicase; Region: PIF1; pfam05970 62977005542 Walker A motif; other site 62977005543 ATP binding site [chemical binding]; other site 62977005544 Walker B motif; other site 62977005545 Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176 62977005546 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 62977005547 dimer interface [polypeptide binding]; other site 62977005548 active site 62977005549 metal binding site [ion binding]; metal-binding site 62977005550 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 62977005551 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 62977005552 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 62977005553 Bacterial transcriptional activator domain; Region: BTAD; smart01043 62977005554 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 62977005555 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 62977005556 NAD(P) binding site [chemical binding]; other site 62977005557 catalytic residues [active] 62977005558 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 62977005559 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 62977005560 catalytic triad [active] 62977005561 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 62977005562 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 62977005563 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 62977005564 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 62977005565 Branched-chain amino acid transport protein (AzlD); Region: AzlD; pfam05437 62977005566 Choloylglycine hydrolase (CGH) is a bile salt-modifying enzyme that hydrolyzes non-peptide carbon-nitrogen bonds in choloylglycine and choloyltaurine, both of which are present in bile. CGH is present in a number of probiotic microbial organisms that...; Region: Ntn_CGH; cd01902 62977005567 Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275 62977005568 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 62977005569 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 62977005570 Tetramer interface [polypeptide binding]; other site 62977005571 active site 62977005572 FMN-binding site [chemical binding]; other site 62977005573 HemK family putative methylases; Region: hemK_fam; TIGR00536 62977005574 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 62977005575 S-adenosylmethionine binding site [chemical binding]; other site 62977005576 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 62977005577 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 62977005578 DNA-binding site [nucleotide binding]; DNA binding site 62977005579 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 62977005580 pyridoxal 5'-phosphate binding site [chemical binding]; other site 62977005581 homodimer interface [polypeptide binding]; other site 62977005582 catalytic residue [active] 62977005583 Uncharacterized conserved protein [Function unknown]; Region: COG2353 62977005584 transketolase; Reviewed; Region: PRK12753 62977005585 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 62977005586 TPP-binding site [chemical binding]; other site 62977005587 dimer interface [polypeptide binding]; other site 62977005588 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 62977005589 PYR/PP interface [polypeptide binding]; other site 62977005590 dimer interface [polypeptide binding]; other site 62977005591 TPP binding site [chemical binding]; other site 62977005592 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 62977005593 S-adenosylmethionine synthetase; Validated; Region: PRK05250 62977005594 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 62977005595 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 62977005596 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 62977005597 Predicted nucleic acid-binding protein, consists of a PIN domain and a Zn-ribbon module [General function prediction only]; Region: COG1439 62977005598 FxsA cytoplasmic membrane protein; Region: FxsA; pfam04186 62977005599 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 62977005600 active site 62977005601 putative DNA-binding cleft [nucleotide binding]; other site 62977005602 dimer interface [polypeptide binding]; other site 62977005603 YjeF-related protein N-terminus; Region: YjeF_N; pfam03853 62977005604 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 62977005605 putative substrate binding site [chemical binding]; other site 62977005606 putative ATP binding site [chemical binding]; other site 62977005607 epoxyqueuosine reductase; Region: TIGR00276 62977005608 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 62977005609 biotin synthase; Provisional; Region: PRK15108 62977005610 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 62977005611 FeS/SAM binding site; other site 62977005612 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 62977005613 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 62977005614 dinuclear metal binding motif [ion binding]; other site 62977005615 ferrichrome outer membrane transporter; Provisional; Region: PRK10044 62977005616 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 62977005617 N-terminal plug; other site 62977005618 ligand-binding site [chemical binding]; other site 62977005619 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 62977005620 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 62977005621 putative acyl-acceptor binding pocket; other site 62977005622 hypothetical protein; Validated; Region: PRK00110 62977005623 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 62977005624 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 62977005625 putative DNA binding site [nucleotide binding]; other site 62977005626 putative Zn2+ binding site [ion binding]; other site 62977005627 AsnC family; Region: AsnC_trans_reg; pfam01037 62977005628 Porin subfamily; Region: Porin_2; pfam02530 62977005629 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 62977005630 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 62977005631 Walker A/P-loop; other site 62977005632 ATP binding site [chemical binding]; other site 62977005633 Q-loop/lid; other site 62977005634 ABC transporter signature motif; other site 62977005635 Walker B; other site 62977005636 D-loop; other site 62977005637 H-loop/switch region; other site 62977005638 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 62977005639 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 62977005640 dimer interface [polypeptide binding]; other site 62977005641 conserved gate region; other site 62977005642 putative PBP binding loops; other site 62977005643 ABC-ATPase subunit interface; other site 62977005644 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 62977005645 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 62977005646 dimer interface [polypeptide binding]; other site 62977005647 conserved gate region; other site 62977005648 putative PBP binding loops; other site 62977005649 ABC-ATPase subunit interface; other site 62977005650 glutamate and aspartate transporter subunit; Provisional; Region: PRK10797 62977005651 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 62977005652 substrate binding pocket [chemical binding]; other site 62977005653 membrane-bound complex binding site; other site 62977005654 hinge residues; other site 62977005655 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 62977005656 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 62977005657 C-terminal domain interface [polypeptide binding]; other site 62977005658 GSH binding site (G-site) [chemical binding]; other site 62977005659 dimer interface [polypeptide binding]; other site 62977005660 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 62977005661 N-terminal domain interface [polypeptide binding]; other site 62977005662 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 62977005663 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 62977005664 active site 62977005665 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 62977005666 Dibenzothiophene (DBT) desulfurization enzyme C; Region: DszC; cd01163 62977005667 Flavin binding site [chemical binding]; other site 62977005668 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 62977005669 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 62977005670 active site 62977005671 non-prolyl cis peptide bond; other site 62977005672 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 62977005673 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 62977005674 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 62977005675 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 62977005676 Walker A/P-loop; other site 62977005677 ATP binding site [chemical binding]; other site 62977005678 Q-loop/lid; other site 62977005679 ABC transporter signature motif; other site 62977005680 Walker B; other site 62977005681 D-loop; other site 62977005682 H-loop/switch region; other site 62977005683 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 62977005684 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 62977005685 dimer interface [polypeptide binding]; other site 62977005686 conserved gate region; other site 62977005687 ABC-ATPase subunit interface; other site 62977005688 GTP-binding protein YchF; Reviewed; Region: PRK09601 62977005689 YchF GTPase; Region: YchF; cd01900 62977005690 G1 box; other site 62977005691 GTP/Mg2+ binding site [chemical binding]; other site 62977005692 Switch I region; other site 62977005693 G2 box; other site 62977005694 Switch II region; other site 62977005695 G3 box; other site 62977005696 G4 box; other site 62977005697 G5 box; other site 62977005698 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 62977005699 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 62977005700 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 62977005701 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 62977005702 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 62977005703 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 62977005704 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 62977005705 ATP-grasp domain; Region: ATP-grasp; pfam02222 62977005706 PII uridylyl-transferase; Provisional; Region: glnD; PRK00275 62977005707 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 62977005708 metal binding triad; other site 62977005709 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 62977005710 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 62977005711 Zn2+ binding site [ion binding]; other site 62977005712 Mg2+ binding site [ion binding]; other site 62977005713 ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900 62977005714 C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899 62977005715 succinyldiaminopimelate transaminase; Provisional; Region: PRK09147 62977005716 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 62977005717 pyridoxal 5'-phosphate binding site [chemical binding]; other site 62977005718 homodimer interface [polypeptide binding]; other site 62977005719 catalytic residue [active] 62977005720 Domain of unknown function (DUF3315); Region: DUF3315; pfam11776 62977005721 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 62977005722 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 62977005723 N-terminal plug; other site 62977005724 ligand-binding site [chemical binding]; other site 62977005725 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 62977005726 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 62977005727 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 62977005728 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 62977005729 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 62977005730 catalytic residues [active] 62977005731 dimer interface [polypeptide binding]; other site 62977005732 methionine sulfoxide reductase B; Provisional; Region: PRK00222 62977005733 SelR domain; Region: SelR; pfam01641 62977005734 aminotransferase AlaT; Validated; Region: PRK09265 62977005735 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 62977005736 pyridoxal 5'-phosphate binding site [chemical binding]; other site 62977005737 homodimer interface [polypeptide binding]; other site 62977005738 catalytic residue [active] 62977005739 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 62977005740 active site 62977005741 homodimer interface [polypeptide binding]; other site 62977005742 homotetramer interface [polypeptide binding]; other site 62977005743 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433 62977005744 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 62977005745 putative active site [active] 62977005746 putative PHP Thumb interface [polypeptide binding]; other site 62977005747 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 62977005748 generic binding surface II; other site 62977005749 generic binding surface I; other site 62977005750 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 62977005751 rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565 62977005752 serine O-acetyltransferase; Region: cysE; TIGR01172 62977005753 Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762 62977005754 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 62977005755 trimer interface [polypeptide binding]; other site 62977005756 active site 62977005757 substrate binding site [chemical binding]; other site 62977005758 CoA binding site [chemical binding]; other site 62977005759 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 62977005760 PGAP1-like protein; Region: PGAP1; pfam07819 62977005761 TENA/THI-4/PQQC family; Region: TENA_THI-4; cl15243 62977005762 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 62977005763 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 62977005764 metal binding site [ion binding]; metal-binding site 62977005765 active site 62977005766 I-site; other site 62977005767 Domain of unknown function (DUF4198); Region: DUF4198; pfam10670 62977005768 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1636 62977005769 acyl-CoA esterase; Provisional; Region: PRK10673 62977005770 PGAP1-like protein; Region: PGAP1; pfam07819 62977005771 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 62977005772 Major Facilitator Superfamily; Region: MFS_1; pfam07690 62977005773 putative substrate translocation pore; other site 62977005774 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK07515 62977005775 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 62977005776 dimer interface [polypeptide binding]; other site 62977005777 active site 62977005778 CoA binding pocket [chemical binding]; other site 62977005779 ATP-dependent helicase HrpA; Region: DEAH_box_HrpA; TIGR01967 62977005780 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 62977005781 ATP binding site [chemical binding]; other site 62977005782 putative Mg++ binding site [ion binding]; other site 62977005783 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 62977005784 nucleotide binding region [chemical binding]; other site 62977005785 ATP-binding site [chemical binding]; other site 62977005786 Helicase associated domain (HA2); Region: HA2; pfam04408 62977005787 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 62977005788 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 62977005789 peroxiredoxin; Region: AhpC; TIGR03137 62977005790 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 62977005791 dimer interface [polypeptide binding]; other site 62977005792 decamer (pentamer of dimers) interface [polypeptide binding]; other site 62977005793 catalytic triad [active] 62977005794 peroxidatic and resolving cysteines [active] 62977005795 short chain dehydrogenase; Provisional; Region: PRK09072 62977005796 classical (c) SDRs; Region: SDR_c; cd05233 62977005797 NAD(P) binding site [chemical binding]; other site 62977005798 active site 62977005799 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cd00232 62977005800 heme binding pocket [chemical binding]; other site 62977005801 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 62977005802 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_3; cd05914 62977005803 acyl-activating enzyme (AAE) consensus motif; other site 62977005804 putative AMP binding site [chemical binding]; other site 62977005805 putative active site [active] 62977005806 putative CoA binding site [chemical binding]; other site 62977005807 Thermostable hemolysin; Region: T_hemolysin; pfam12261 62977005808 Protein of unknown function (DUF861); Region: Cupin_3; cl17594 62977005809 Sensors of blue-light using FAD; Region: BLUF; pfam04940 62977005810 Domain of unknown function (DUF4385); Region: DUF4385; pfam14328 62977005811 aromatic amino acid exporter; Provisional; Region: PRK11689 62977005812 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 62977005813 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 62977005814 N-terminal plug; other site 62977005815 ligand-binding site [chemical binding]; other site 62977005816 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 62977005817 Siderophore biosynthesis protein domain; Region: AlcB; smart01006 62977005818 Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480 62977005819 Uncharacterized Fe-S protein [General function prediction only]; Region: FhuF; COG4114 62977005820 FhuF 2Fe-2S C-terminal domain; Region: FhuF_C; pfam11575 62977005821 IucA / IucC family; Region: IucA_IucC; pfam04183 62977005822 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 62977005823 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 62977005824 IucA / IucC family; Region: IucA_IucC; pfam04183 62977005825 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 62977005826 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 62977005827 Major Facilitator Superfamily; Region: MFS_1; pfam07690 62977005828 putative substrate translocation pore; other site 62977005829 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 62977005830 Lysine/ornithine N-monooxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: IucD; COG3486 62977005831 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 62977005832 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 62977005833 IucA / IucC family; Region: IucA_IucC; pfam04183 62977005834 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 62977005835 Sensors of blue-light using FAD; Region: BLUF; smart01034 62977005836 Sensors of blue-light using FAD; Region: BLUF; smart01034 62977005837 TIGR04255 family protein; Region: sporadTIGR04255 62977005838 Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; pfam09669 62977005839 Phage antirepressor protein KilAC domain; Region: ANT; pfam03374 62977005840 Arc-like DNA binding domain; Region: Arc; pfam03869 62977005841 Alpha/beta hydrolase of unknown function (DUF900); Region: DUF900; pfam05990 62977005842 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 62977005843 TIGR02594 family protein; Region: TIGR02594 62977005844 Putative phage tail protein; Region: Phage-tail_3; pfam13550 62977005845 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 62977005846 NlpC/P60 family; Region: NLPC_P60; cl17555 62977005847 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 62977005848 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 62977005849 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 62977005850 CotH protein; Region: CotH; pfam08757 62977005851 Uncharacterized conserved protein (DUF2163); Region: DUF2163; pfam09931 62977005852 Phage conserved hypothetical protein BR0599; Region: Phage_BR0599; pfam09356 62977005853 Conserved hypothetical protein 2217 (DUF2460); Region: DUF2460; pfam09343 62977005854 MAEBL; Provisional; Region: PTZ00121 62977005855 Protein of unknown function (DUF4054); Region: DUF4054; pfam13262 62977005856 Uncharacterized protein conserved in bacteria (DUF2184); Region: DUF2184; pfam09950 62977005857 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4834 62977005858 Uncharacterized protein conserved in bacteria (DUF2213); Region: DUF2213; pfam09979 62977005859 AntA/AntB antirepressor; Region: AntA; pfam08346 62977005860 ORF11CD3 domain; Region: ORF11CD3; pfam10549 62977005861 Arc-like DNA binding domain; Region: Arc; pfam03869 62977005862 Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072 62977005863 phage-related protein, HI1409 family; Region: phge_rel_HI1409; TIGR01555 62977005864 Protein of unknown function (DUF1073); Region: DUF1073; pfam06381 62977005865 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5410 62977005866 Terminase-like family; Region: Terminase_6; pfam03237 62977005867 Phage-related terminase [General function prediction only]; Region: COG5362; cl02216 62977005868 Uncharacterized conserved protein (DUF2280); Region: DUF2280; pfam10045 62977005869 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 62977005870 non-specific DNA binding site [nucleotide binding]; other site 62977005871 salt bridge; other site 62977005872 sequence-specific DNA binding site [nucleotide binding]; other site 62977005873 Plasmid maintenance system killer protein; Region: Plasmid_killer; pfam05015 62977005874 replicative DNA helicase; Region: DnaB; TIGR00665 62977005875 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 62977005876 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 62977005877 Walker A motif; other site 62977005878 ATP binding site [chemical binding]; other site 62977005879 Walker B motif; other site 62977005880 Phage regulatory protein CII (CP76); Region: Phage_CP76; pfam06892 62977005881 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 62977005882 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 62977005883 non-specific DNA binding site [nucleotide binding]; other site 62977005884 salt bridge; other site 62977005885 sequence-specific DNA binding site [nucleotide binding]; other site 62977005886 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 62977005887 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 62977005888 active site 62977005889 DNA binding site [nucleotide binding] 62977005890 Int/Topo IB signature motif; other site 62977005891 Domain of unknown function (DUF3488); Region: DUF3488; pfam11992 62977005892 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 62977005893 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 62977005894 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 62977005895 Protein of unknown function DUF58; Region: DUF58; pfam01882 62977005896 MoxR-like ATPases [General function prediction only]; Region: COG0714 62977005897 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 62977005898 Walker A motif; other site 62977005899 ATP binding site [chemical binding]; other site 62977005900 Walker B motif; other site 62977005901 arginine finger; other site 62977005902 Protein of unknown function (DUF466); Region: DUF466; pfam04328 62977005903 carbon starvation protein A; Provisional; Region: PRK15015 62977005904 Carbon starvation protein CstA; Region: CstA; pfam02554 62977005905 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 62977005906 elongation factor P; Validated; Region: PRK00529 62977005907 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 62977005908 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 62977005909 RNA binding site [nucleotide binding]; other site 62977005910 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 62977005911 RNA binding site [nucleotide binding]; other site 62977005912 Radical SAM superfamily; Region: Radical_SAM; pfam04055 62977005913 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 62977005914 FeS/SAM binding site; other site 62977005915 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 62977005916 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 62977005917 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 62977005918 SBF-like CPA transporter family (DUF4137); Region: DUF4137; pfam13593 62977005919 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 62977005920 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 62977005921 dimer interface [polypeptide binding]; other site 62977005922 active site 62977005923 metal binding site [ion binding]; metal-binding site 62977005924 glutathione binding site [chemical binding]; other site 62977005925 muropeptide transporter; Validated; Region: ampG; cl17669 62977005926 muropeptide transporter; Validated; Region: ampG; cl17669 62977005927 muropeptide transporter; Validated; Region: ampG; cl17669 62977005928 AAA domain; Region: AAA_32; pfam13654 62977005929 lon-related putative ATP-dependent protease; Region: lon_rel; TIGR00764 62977005930 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 62977005931 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4339 62977005932 hypothetical protein; Validated; Region: PRK02101 62977005933 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2945 62977005934 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 62977005935 Xaa-His dipeptidase; Region: aa-his-dipept; TIGR01893 62977005936 M20 Peptidase D has specificity for beta-alanyl-L-histidine dipeptide; Region: M20_pepD; cd03890 62977005937 metal binding site [ion binding]; metal-binding site 62977005938 dimer interface [polypeptide binding]; other site 62977005939 bifunctional cyclohexadienyl dehydrogenase/ 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK14806 62977005940 prephenate dehydrogenase; Validated; Region: PRK08507 62977005941 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 62977005942 hinge; other site 62977005943 active site 62977005944 Chorismate mutase type II; Region: CM_2; cl00693 62977005945 Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077 62977005946 Prephenate dehydratase; Region: PDT; pfam00800 62977005947 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 62977005948 putative L-Phe binding site [chemical binding]; other site 62977005949 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 62977005950 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 62977005951 intracellular protease, PfpI family; Region: PfpI; TIGR01382 62977005952 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 62977005953 proposed catalytic triad [active] 62977005954 conserved cys residue [active] 62977005955 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 62977005956 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 62977005957 active site 62977005958 C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663 62977005959 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 62977005960 hypothetical protein; Validated; Region: PRK09071 62977005961 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 62977005962 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 62977005963 Protein of unknown function (DUF1315); Region: DUF1315; pfam07023 62977005964 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK01231 62977005965 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03708 62977005966 penicillin-binding protein 1B; Region: PBP_1b; TIGR02071 62977005967 Transglycosylase; Region: Transgly; pfam00912 62977005968 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 62977005969 hypothetical protein; Provisional; Region: PRK08999 62977005970 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 62977005971 active site 62977005972 8-oxo-dGMP binding site [chemical binding]; other site 62977005973 nudix motif; other site 62977005974 metal binding site [ion binding]; metal-binding site 62977005975 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 62977005976 thiamine phosphate binding site [chemical binding]; other site 62977005977 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 62977005978 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 62977005979 dimer interface [polypeptide binding]; other site 62977005980 phosphorylation site [posttranslational modification] 62977005981 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 62977005982 ATP binding site [chemical binding]; other site 62977005983 Mg2+ binding site [ion binding]; other site 62977005984 G-X-G motif; other site 62977005985 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 62977005986 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 62977005987 active site 62977005988 phosphorylation site [posttranslational modification] 62977005989 intermolecular recognition site; other site 62977005990 dimerization interface [polypeptide binding]; other site 62977005991 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 62977005992 DNA binding site [nucleotide binding] 62977005993 Bacterial OB fold (BOF) protein; Region: BOF; cl01196 62977005994 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 62977005995 Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804 62977005996 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 62977005997 Walker A motif; other site 62977005998 ATP binding site [chemical binding]; other site 62977005999 Walker B motif; other site 62977006000 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 62977006001 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 62977006002 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 62977006003 metal binding site [ion binding]; metal-binding site 62977006004 active site 62977006005 I-site; other site 62977006006 Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281 62977006007 homodimer interaction site [polypeptide binding]; other site 62977006008 cofactor binding site; other site 62977006009 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 62977006010 Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195 62977006011 FAD binding pocket [chemical binding]; other site 62977006012 FAD binding motif [chemical binding]; other site 62977006013 phosphate binding motif [ion binding]; other site 62977006014 beta-alpha-beta structure motif; other site 62977006015 NAD binding pocket [chemical binding]; other site 62977006016 Transcriptional regulators [Transcription]; Region: GntR; COG1802 62977006017 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 62977006018 DNA-binding site [nucleotide binding]; DNA binding site 62977006019 FCD domain; Region: FCD; pfam07729 62977006020 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 62977006021 trimer interface [polypeptide binding]; other site 62977006022 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 62977006023 eyelet of channel; other site 62977006024 uncharacterized nucleobase-cation-symport-1 (NCS1) transporter subfamily; solute-binding domain; Region: SLC-NCS1sbd_u1; cd11555 62977006025 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 62977006026 Na binding site [ion binding]; other site 62977006027 putative substrate binding site [chemical binding]; other site 62977006028 Hydantoin racemase [Amino acid transport and metabolism]; Region: COG4126 62977006029 The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363 62977006030 putative active site [active] 62977006031 metal binding site [ion binding]; metal-binding site 62977006032 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 62977006033 alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317 62977006034 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974 62977006035 catalytic residue [active] 62977006036 TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026 62977006037 catalytic residues [active] 62977006038 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 62977006039 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 62977006040 Toxic anion resistance protein (TelA); Region: TelA; pfam05816 62977006041 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 62977006042 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 62977006043 dimer interface [polypeptide binding]; other site 62977006044 active site 62977006045 glycine-pyridoxal phosphate binding site [chemical binding]; other site 62977006046 folate binding site [chemical binding]; other site 62977006047 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 62977006048 Secretory lipase; Region: LIP; pfam03583 62977006049 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 62977006050 exodeoxyribonuclease X; Provisional; Region: PRK07983 62977006051 active site 62977006052 catalytic site [active] 62977006053 substrate binding site [chemical binding]; other site 62977006054 Protein of unknown function (DUF3820); Region: DUF3820; cl01411 62977006055 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 62977006056 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 62977006057 Walker A/P-loop; other site 62977006058 ATP binding site [chemical binding]; other site 62977006059 Q-loop/lid; other site 62977006060 ABC transporter signature motif; other site 62977006061 Walker B; other site 62977006062 D-loop; other site 62977006063 H-loop/switch region; other site 62977006064 inner membrane transport permease; Provisional; Region: PRK15066 62977006065 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 62977006066 7-cyano-7-deazaguanine reductase; Region: QueF; TIGR03138 62977006067 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2904 62977006068 Enzyme related to GTP cyclohydrolase I [General function prediction only]; Region: COG0780 62977006069 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 62977006070 Transglycosylase SLT domain; Region: SLT_2; pfam13406 62977006071 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 62977006072 N-acetyl-D-glucosamine binding site [chemical binding]; other site 62977006073 Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797 62977006074 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 62977006075 Protein of unknown function (DUF962); Region: DUF962; cl01879 62977006076 Protein of unknown function (DUF3465); Region: DUF3465; pfam11948 62977006077 elongation factor Ts; Provisional; Region: tsf; PRK09377 62977006078 UBA/TS-N domain; Region: UBA; pfam00627 62977006079 Elongation factor TS; Region: EF_TS; pfam00889 62977006080 Elongation factor TS; Region: EF_TS; pfam00889 62977006081 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 62977006082 rRNA interaction site [nucleotide binding]; other site 62977006083 S8 interaction site; other site 62977006084 putative laminin-1 binding site; other site 62977006085 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 62977006086 active site 62977006087 Outer membrane protein W [Cell envelope biogenesis, outer membrane]; Region: OmpW; COG3047 62977006088 soluble pyridine nucleotide transhydrogenase; Provisional; Region: PRK05249 62977006089 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 62977006090 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 62977006091 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 62977006092 lipoyl synthase; Provisional; Region: PRK05481 62977006093 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 62977006094 FeS/SAM binding site; other site 62977006095 acyl-CoA dehydrogenase; Reviewed; Region: fadE; PRK09463 62977006096 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 62977006097 active site 62977006098 Domain of unknown function (DUF1974); Region: DUF1974; pfam09317 62977006099 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 62977006100 MASE2 domain; Region: MASE2; pfam05230 62977006101 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 62977006102 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 62977006103 metal binding site [ion binding]; metal-binding site 62977006104 active site 62977006105 I-site; other site 62977006106 proline/glycine betaine transporter; Provisional; Region: PRK10642 62977006107 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 62977006108 putative substrate translocation pore; other site 62977006109 Osmosensory transporter coiled coil; Region: Osmo_CC; pfam08946 62977006110 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 62977006111 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 62977006112 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 62977006113 homotetramer interface [polypeptide binding]; other site 62977006114 ligand binding site [chemical binding]; other site 62977006115 catalytic site [active] 62977006116 NAD binding site [chemical binding]; other site 62977006117 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 62977006118 FAD binding site [chemical binding]; other site 62977006119 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 62977006120 RNA methyltransferase, RsmE family; Region: TIGR00046 62977006121 bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed; Region: PRK07232 62977006122 Malic enzyme, N-terminal domain; Region: malic; pfam00390 62977006123 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 62977006124 putative NAD(P) binding site [chemical binding]; other site 62977006125 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 62977006126 multifunctional tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase; Reviewed; Region: cca; PRK10885 62977006127 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 62977006128 active site 62977006129 NTP binding site [chemical binding]; other site 62977006130 metal binding triad [ion binding]; metal-binding site 62977006131 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 62977006132 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 62977006133 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562 62977006134 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 62977006135 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 62977006136 Cyd operon protein YbgE (Cyd_oper_YbgE); Region: Cyd_oper_YbgE; pfam09600 62977006137 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 62977006138 Coenzyme A binding pocket [chemical binding]; other site 62977006139 Uncharacterized protein conserved in bacteria (DUF2057); Region: DUF2057; pfam09829 62977006140 Nitroreductase-like family 4. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_4; cd02140 62977006141 dimer interface [polypeptide binding]; other site 62977006142 FMN binding site [chemical binding]; other site 62977006143 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 62977006144 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 62977006145 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 62977006146 P loop; other site 62977006147 GTP binding site [chemical binding]; other site 62977006148 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 62977006149 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 62977006150 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 62977006151 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 62977006152 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 62977006153 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 62977006154 Protein of unknown function (DUF2750); Region: DUF2750; pfam11042 62977006155 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_10; cd04623 62977006156 FOG: CBS domain [General function prediction only]; Region: COG0517 62977006157 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3825 62977006158 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 62977006159 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 62977006160 Walker A motif; other site 62977006161 ATP binding site [chemical binding]; other site 62977006162 Walker B motif; other site 62977006163 arginine finger; other site 62977006164 YcgL domain; Region: YcgL; pfam05166 62977006165 ribonuclease D; Region: rnd; TIGR01388 62977006166 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 62977006167 catalytic site [active] 62977006168 putative active site [active] 62977006169 putative substrate binding site [chemical binding]; other site 62977006170 HRDC domain; Region: HRDC; pfam00570 62977006171 recombination protein RecR; Reviewed; Region: recR; PRK00076 62977006172 RecR protein; Region: RecR; pfam02132 62977006173 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 62977006174 putative active site [active] 62977006175 putative metal-binding site [ion binding]; other site 62977006176 tetramer interface [polypeptide binding]; other site 62977006177 hypothetical protein; Validated; Region: PRK00153 62977006178 O-succinylhomoserine sulfhydrylase; Validated; Region: PRK08133 62977006179 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 62977006180 homodimer interface [polypeptide binding]; other site 62977006181 substrate-cofactor binding pocket; other site 62977006182 pyridoxal 5'-phosphate binding site [chemical binding]; other site 62977006183 catalytic residue [active] 62977006184 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 62977006185 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 62977006186 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 62977006187 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 62977006188 HIT family signature motif; other site 62977006189 catalytic residue [active] 62977006190 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 62977006191 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 62977006192 eyelet of channel; other site 62977006193 trimer interface [polypeptide binding]; other site 62977006194 Bacterial protein of unknown function (DUF937); Region: DUF937; cl01528 62977006195 Protein of unknown function (DUF2797); Region: DUF2797; pfam10977 62977006196 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 62977006197 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 62977006198 Outer membrane receptor for ferric coprogen and ferric-rhodotorulic acid [Inorganic ion transport and metabolism]; Region: FhuE; COG4773 62977006199 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 62977006200 N-terminal plug; other site 62977006201 ligand-binding site [chemical binding]; other site 62977006202 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 62977006203 PepSY-associated TM helix; Region: PepSY_TM_3; pfam13706 62977006204 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 62977006205 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 62977006206 phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261 62977006207 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 62977006208 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 62977006209 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 62977006210 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 62977006211 Transporter associated domain; Region: CorC_HlyC; smart01091 62977006212 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 62977006213 MarR family; Region: MarR_2; pfam12802 62977006214 Uncharacterized ACR, COG2135; Region: DUF159; pfam02586 62977006215 malate synthase G; Provisional; Region: PRK02999 62977006216 active site 62977006217 Predicted ATPase [General function prediction only]; Region: COG1485 62977006218 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 62977006219 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 62977006220 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 62977006221 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 62977006222 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 62977006223 Membrane protein of unknown function (DUF340); Region: DUF340; pfam03956 62977006224 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 62977006225 active site 62977006226 dimer interface [polypeptide binding]; other site 62977006227 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 62977006228 non-specific DNA binding site [nucleotide binding]; other site 62977006229 salt bridge; other site 62977006230 sequence-specific DNA binding site [nucleotide binding]; other site 62977006231 Cupin domain; Region: Cupin_2; pfam07883 62977006232 AzlC protein; Region: AzlC; pfam03591 62977006233 Branched-chain amino acid transport protein (AzlD); Region: AzlD; cl00735 62977006234 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 62977006235 IHF dimer interface [polypeptide binding]; other site 62977006236 IHF - DNA interface [nucleotide binding]; other site 62977006237 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 62977006238 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 62977006239 RNA binding site [nucleotide binding]; other site 62977006240 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 62977006241 RNA binding site [nucleotide binding]; other site 62977006242 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 62977006243 RNA binding site [nucleotide binding]; other site 62977006244 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 62977006245 RNA binding site [nucleotide binding]; other site 62977006246 S1_RPS1_repeat_ec5: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec5; cd05690 62977006247 RNA binding site [nucleotide binding]; other site 62977006248 S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec6; cd05691 62977006249 RNA binding site [nucleotide binding]; other site 62977006250 cytidylate kinase; Provisional; Region: cmk; PRK00023 62977006251 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 62977006252 CMP-binding site; other site 62977006253 The sites determining sugar specificity; other site 62977006254 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 62977006255 putative hydrophobic ligand binding site [chemical binding]; other site 62977006256 protein interface [polypeptide binding]; other site 62977006257 gate; other site 62977006258 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 62977006259 nucleoside/Zn binding site; other site 62977006260 dimer interface [polypeptide binding]; other site 62977006261 catalytic motif [active] 62977006262 3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617 62977006263 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 62977006264 substrate binding site [chemical binding]; other site 62977006265 oxyanion hole (OAH) forming residues; other site 62977006266 trimer interface [polypeptide binding]; other site 62977006267 2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766 62977006268 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 62977006269 ligand binding site [chemical binding]; other site 62977006270 active site 62977006271 UGI interface [polypeptide binding]; other site 62977006272 catalytic site [active] 62977006273 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 62977006274 Type II secretion system (T2SS), protein K; Region: T2SK; pfam03934 62977006275 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 62977006276 Type II secretion system (T2SS), protein J; Region: T2SJ; pfam11612 62977006277 Type II secretion system (T2SS), protein I; Region: T2SI; pfam02501 62977006278 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 62977006279 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 62977006280 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 62977006281 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 62977006282 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 62977006283 active site 62977006284 PilZ domain; Region: PilZ; cl01260 62977006285 DNA polymerase III, delta' subunit; Region: holB; TIGR00678 62977006286 DNA polymerase III subunit delta'; Validated; Region: PRK08485 62977006287 ATPase involved in DNA replication [DNA replication, recombination, and repair]; Region: HolB; COG0470 62977006288 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 62977006289 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 62977006290 Ligand binding site; other site 62977006291 oligomer interface; other site 62977006292 Tetraacyldisaccharide-1-P 4'-kinase [Cell envelope biogenesis, outer membrane]; Region: LpxK; COG1663 62977006293 Tetraacyldisaccharide-1-P 4'-kinase; Region: LpxK; pfam02606 62977006294 lipid A export permease/ATP-binding protein MsbA; Region: MsbA_lipidA; TIGR02203 62977006295 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 62977006296 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 62977006297 Walker A/P-loop; other site 62977006298 ATP binding site [chemical binding]; other site 62977006299 Q-loop/lid; other site 62977006300 ABC transporter signature motif; other site 62977006301 Walker B; other site 62977006302 D-loop; other site 62977006303 H-loop/switch region; other site 62977006304 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 62977006305 ParB-like nuclease domain; Region: ParB; smart00470 62977006306 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 62977006307 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 62977006308 P-loop; other site 62977006309 Magnesium ion binding site [ion binding]; other site 62977006310 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 62977006311 Magnesium ion binding site [ion binding]; other site 62977006312 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 62977006313 rRNA small subunit methyltransferase G; Region: GidB; pfam02527 62977006314 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 62977006315 NTP_transferase_like_1 is a member of the nucleotidyl transferase family; Region: NTP_transferase_like_1; cd06422 62977006316 Substrate binding site; other site 62977006317 metal-binding site 62977006318 Predicted phosphotransferase related to Ser/Thr protein kinases [General function prediction only]; Region: COG3178 62977006319 Phosphotransferase enzyme family; Region: APH; pfam01636 62977006320 Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452 62977006321 OstA-like protein; Region: OstA; cl00844 62977006322 Organic solvent tolerance protein; Region: OstA_C; pfam04453 62977006323 peptidyl-prolyl cis-trans isomerase SurA; Provisional; Region: PRK10770 62977006324 SurA N-terminal domain; Region: SurA_N; pfam09312 62977006325 PPIC-type PPIASE domain; Region: Rotamase_2; cl08278 62977006326 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 62977006327 bacterial Hfq-like; Region: Hfq; cd01716 62977006328 hexamer interface [polypeptide binding]; other site 62977006329 Sm1 motif; other site 62977006330 RNA binding site [nucleotide binding]; other site 62977006331 Sm2 motif; other site 62977006332 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 62977006333 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 62977006334 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 62977006335 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 62977006336 ATP binding site [chemical binding]; other site 62977006337 Mg2+ binding site [ion binding]; other site 62977006338 G-X-G motif; other site 62977006339 MutL_Trans_MutL: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to Escherichia coli MutL. EcMutL belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second...; Region: MutL_Trans_MutL; cd03482 62977006340 ATP binding site [chemical binding]; other site 62977006341 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 62977006342 Uncharacterized P-loop hydrolase UPF0079; Region: UPF0079; cl00520 62977006343 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 62977006344 Pseudouridine synthase, a subgroup of the RluA family; Region: PSRA_1; cd02558 62977006345 probable active site [active] 62977006346 RelB antitoxin; Region: RelB; cl01171 62977006347 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 62977006348 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 62977006349 Coenzyme A binding pocket [chemical binding]; other site 62977006350 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 62977006351 RNA binding surface [nucleotide binding]; other site 62977006352 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 62977006353 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 62977006354 active site 62977006355 uracil binding [chemical binding]; other site 62977006356 Protein of unknown function (DUF441); Region: DUF441; pfam04284 62977006357 Transcriptional regulator [Transcription]; Region: LysR; COG0583 62977006358 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 62977006359 The C-terminal substrate binding domain of LysR-type transcriptional regulator metR, which regulates the expression of methionine biosynthetic genes, contains type 2 periplasmic binding fold; Region: PBP2_MetR; cd08441 62977006360 putative dimerization interface [polypeptide binding]; other site 62977006361 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 62977006362 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 62977006363 putative substrate translocation pore; other site 62977006364 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 62977006365 active site 62977006366 tetramer interface [polypeptide binding]; other site 62977006367 Isopenicillin N synthase and related dioxygenases [General function prediction only]; Region: PcbC; COG3491 62977006368 non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226 62977006369 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171 62977006370 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 62977006371 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 62977006372 Nucleoside recognition; Region: Gate; pfam07670 62977006373 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 62977006374 Ion transport protein; Region: Ion_trans; pfam00520 62977006375 Ion channel; Region: Ion_trans_2; pfam07885 62977006376 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 62977006377 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 62977006378 substrate binding site [chemical binding]; other site 62977006379 dimer interface [polypeptide binding]; other site 62977006380 ATP binding site [chemical binding]; other site 62977006381 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 62977006382 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 62977006383 non-specific DNA binding site [nucleotide binding]; other site 62977006384 salt bridge; other site 62977006385 sequence-specific DNA binding site [nucleotide binding]; other site 62977006386 bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238 62977006387 Aconitase B swivel domain. Aconitate hydratase B is involved in energy metabolism as part of the TCA cycle. It catalyses the formation of cis-aconitate from citrate. This is the aconitase swivel domain, which undergoes swivelling conformational change in...; Region: AcnB_Swivel; cd01576 62977006388 substrate binding site [chemical binding]; other site 62977006389 Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle; Region: AcnB; cd01581 62977006390 substrate binding site [chemical binding]; other site 62977006391 ligand binding site [chemical binding]; other site 62977006392 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 62977006393 putative homodimer interface [polypeptide binding]; other site 62977006394 putative homotetramer interface [polypeptide binding]; other site 62977006395 putative allosteric switch controlling residues; other site 62977006396 putative metal binding site [ion binding]; other site 62977006397 putative homodimer-homodimer interface [polypeptide binding]; other site 62977006398 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 62977006399 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 62977006400 metal-binding site [ion binding] 62977006401 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 62977006402 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 62977006403 metal-binding site [ion binding] 62977006404 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 62977006405 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 62977006406 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 62977006407 metal-binding site [ion binding] 62977006408 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911 62977006409 Family of unknown function (DUF490); Region: DUF490; pfam04357 62977006410 Surface antigen; Region: Bac_surface_Ag; pfam01103 62977006411 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 62977006412 putative substrate translocation pore; other site 62977006413 Demethoxyubiquinone hydroxylase, ferritin-like diiron-binding domain; Region: DMQH; cd01042 62977006414 diiron binding motif [ion binding]; other site 62977006415 Protein of unknown function (DUF2799); Region: DUF2799; pfam10973 62977006416 Protein of unknown function (DUF1595); Region: PSD5; pfam07637 62977006417 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cl00233 62977006418 catalytic center binding site [active] 62977006419 ATP binding site [chemical binding]; other site 62977006420 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 62977006421 homooctamer interface [polypeptide binding]; other site 62977006422 active site 62977006423 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 62977006424 ABC1 family; Region: ABC1; cl17513 62977006425 molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690 62977006426 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 62977006427 ATP binding site [chemical binding]; other site 62977006428 substrate interface [chemical binding]; other site 62977006429 Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443 62977006430 Nucleotide-binding domain of Escherichia coli HscC and similar proteins; Region: HscC_like_NBD; cd10235 62977006431 nucleotide binding site [chemical binding]; other site 62977006432 putative NEF/HSP70 interaction site [polypeptide binding]; other site 62977006433 SBD interface [polypeptide binding]; other site 62977006434 Predicted integral membrane protein [Function unknown]; Region: COG0392 62977006435 Uncharacterized conserved protein [Function unknown]; Region: COG2898 62977006436 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 62977006437 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08217 62977006438 17hydroxysteroid dehydrogenase type 10 (HSD10)-like, classical (c) SDRs; Region: HSD10-like_SDR_c; cd05371 62977006439 NAD binding site [chemical binding]; other site 62977006440 homodimer interface [polypeptide binding]; other site 62977006441 homotetramer interface [polypeptide binding]; other site 62977006442 active site 62977006443 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 62977006444 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 62977006445 S-adenosylmethionine binding site [chemical binding]; other site 62977006446 peptide chain release factor 1; Validated; Region: prfA; PRK00591 62977006447 This domain is found in peptide chain release factors; Region: PCRF; smart00937 62977006448 RF-1 domain; Region: RF-1; pfam00472 62977006449 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 62977006450 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 62977006451 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347 62977006452 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 62977006453 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 62977006454 metal binding site [ion binding]; metal-binding site 62977006455 active site 62977006456 I-site; other site 62977006457 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 62977006458 PEP synthetase regulatory protein; Provisional; Region: PRK05339 62977006459 phosphoenolpyruvate synthase; Validated; Region: PRK06464 62977006460 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 62977006461 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 62977006462 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 62977006463 Domain of unknown function (DUF4339); Region: DUF4339; pfam14237 62977006464 RDD family; Region: RDD; pfam06271 62977006465 cytochrome o ubiquinol oxidase subunit II; Region: CyoA; TIGR01433 62977006466 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 62977006467 COX Aromatic Rich Motif; Region: COX_ARM; pfam06481 62977006468 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 62977006469 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 62977006470 D-pathway; other site 62977006471 Putative ubiquinol binding site [chemical binding]; other site 62977006472 Low-spin heme (heme b) binding site [chemical binding]; other site 62977006473 Putative water exit pathway; other site 62977006474 Binuclear center (heme o3/CuB) [ion binding]; other site 62977006475 K-pathway; other site 62977006476 Putative proton exit pathway; other site 62977006477 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 62977006478 Subunit I/III interface [polypeptide binding]; other site 62977006479 Subunit III/IV interface [polypeptide binding]; other site 62977006480 cytochrome o ubiquinol oxidase subunit IV; Provisional; Region: PRK10582 62977006481 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 62977006482 UbiA prenyltransferase family; Region: UbiA; pfam01040 62977006483 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 62977006484 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 62977006485 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 62977006486 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 62977006487 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 62977006488 replicative DNA helicase; Region: DnaB; TIGR00665 62977006489 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 62977006490 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 62977006491 Walker A motif; other site 62977006492 ATP binding site [chemical binding]; other site 62977006493 Walker B motif; other site 62977006494 DNA binding loops [nucleotide binding] 62977006495 alanine racemase; Reviewed; Region: alr; PRK00053 62977006496 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827 62977006497 active site 62977006498 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 62977006499 substrate binding site [chemical binding]; other site 62977006500 catalytic residues [active] 62977006501 dimer interface [polypeptide binding]; other site 62977006502 Predicted proteasome-type protease [Posttranslational modification, protein turnover, chaperones]; Region: COG3484 62977006503 Bacterial proteasome, beta subunit. The 20S proteasome, multisubunit proteolytic complex, is the central enzyme of nonlysosomal protein degradation in both the cytosol and nucleus. It is composed of 28 subunits arranged as four homoheptameric rings that...; Region: proteasome_beta_bacterial; cd03765 62977006504 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 62977006505 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 62977006506 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 62977006507 Uncharacterized conserved protein [Function unknown]; Region: COG2308 62977006508 Predicted transcriptional regulator [Transcription]; Region: COG2378 62977006509 WYL domain; Region: WYL; pfam13280 62977006510 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 62977006511 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 62977006512 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 62977006513 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 62977006514 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 62977006515 S-adenosylmethionine binding site [chemical binding]; other site 62977006516 zinc-ribbon domain; Region: zinc_ribbon_5; cl11777 62977006517 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 62977006518 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 62977006519 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 62977006520 purine monophosphate binding site [chemical binding]; other site 62977006521 dimer interface [polypeptide binding]; other site 62977006522 putative catalytic residues [active] 62977006523 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 62977006524 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 62977006525 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 62977006526 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 62977006527 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 62977006528 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 62977006529 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 62977006530 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 62977006531 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 62977006532 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 62977006533 Walker A/P-loop; other site 62977006534 ATP binding site [chemical binding]; other site 62977006535 Q-loop/lid; other site 62977006536 ABC transporter signature motif; other site 62977006537 Walker B; other site 62977006538 D-loop; other site 62977006539 H-loop/switch region; other site 62977006540 NIL domain; Region: NIL; pfam09383 62977006541 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 62977006542 dimer interface [polypeptide binding]; other site 62977006543 conserved gate region; other site 62977006544 ABC-ATPase subunit interface; other site 62977006545 hydroxyacylglutathione hydrolase; Region: GSH_gloB; TIGR03413 62977006546 4-hydroxybenzoate octaprenyltransferase; Reviewed; Region: ubiA; PRK12848 62977006547 UbiA prenyltransferase family; Region: UbiA; pfam01040 62977006548 Chorismate lyase; Region: Chor_lyase; cl01230 62977006549 glutamine synthetase; Provisional; Region: glnA; PRK09469 62977006550 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 62977006551 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 62977006552 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 62977006553 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 62977006554 glutamine binding [chemical binding]; other site 62977006555 catalytic triad [active] 62977006556 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 62977006557 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 62977006558 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 62977006559 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 62977006560 active site 62977006561 ribulose/triose binding site [chemical binding]; other site 62977006562 phosphate binding site [ion binding]; other site 62977006563 substrate (anthranilate) binding pocket [chemical binding]; other site 62977006564 product (indole) binding pocket [chemical binding]; other site 62977006565 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2840 62977006566 Smr domain; Region: Smr; pfam01713 62977006567 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 62977006568 xanthine dehydrogenase accessory protein XdhC; Region: xanthine_xdhC; TIGR02964 62977006569 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 62977006570 XdhC Rossmann domain; Region: XdhC_C; pfam13478 62977006571 xanthine dehydrogenase, molybdopterin binding subunit; Region: xanthine_xdhB; TIGR02965 62977006572 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 62977006573 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 62977006574 xanthine dehydrogenase, small subunit; Region: xanthine_xdhA; TIGR02963 62977006575 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 62977006576 catalytic loop [active] 62977006577 iron binding site [ion binding]; other site 62977006578 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 62977006579 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450 62977006580 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 62977006581 homodecamer interface [polypeptide binding]; other site 62977006582 GTP cyclohydrolase I; Provisional; Region: PLN03044 62977006583 active site 62977006584 putative catalytic site residues [active] 62977006585 zinc binding site [ion binding]; other site 62977006586 GTP-CH-I/GFRP interaction surface; other site 62977006587 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 62977006588 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 62977006589 putative transporter; Provisional; Region: PRK12382 62977006590 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 62977006591 putative substrate translocation pore; other site 62977006592 Protein of unknown function (DUF817); Region: DUF817; pfam05675 62977006593 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 62977006594 substrate binding site [chemical binding]; other site 62977006595 active site 62977006596 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 62977006597 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 62977006598 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 62977006599 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 62977006600 Pirin-related protein [General function prediction only]; Region: COG1741 62977006601 Pirin; Region: Pirin; pfam02678 62977006602 CRISPR/Cas system-associated protein Cas3/Cas2; Region: Cas3_Cas2_I-F; cd09673 62977006603 CRISPR-associated helicase Cas3, subtype I-F/YPEST; Region: cas3_yersinia; TIGR02562 62977006604 Phage antirepressor protein KilAC domain; Region: ANT; cl01462 62977006605 CRISPR/Cas system-associated RAMP superfamily protein Csy2; Region: Csy2_I-F; cd09676 62977006606 CRISPR/Cas system-associated RAMP superfamily protein Csy3; Region: Csy3_I-F; cd09677 62977006607 CRISPR/Cas system-associated RAMP superfamily protein Cas6f; Region: Cas6_I-F; cl09835 62977006608 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-F; cd09718 62977006609 Response regulator receiver domain; Region: Response_reg; pfam00072 62977006610 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 62977006611 active site 62977006612 phosphorylation site [posttranslational modification] 62977006613 intermolecular recognition site; other site 62977006614 dimerization interface [polypeptide binding]; other site 62977006615 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 62977006616 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 62977006617 DNA binding residues [nucleotide binding] 62977006618 dimerization interface [polypeptide binding]; other site 62977006619 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 62977006620 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 62977006621 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 62977006622 dimer interface [polypeptide binding]; other site 62977006623 phosphorylation site [posttranslational modification] 62977006624 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 62977006625 ATP binding site [chemical binding]; other site 62977006626 Mg2+ binding site [ion binding]; other site 62977006627 G-X-G motif; other site 62977006628 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 62977006629 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 62977006630 active site 62977006631 phosphorylation site [posttranslational modification] 62977006632 intermolecular recognition site; other site 62977006633 dimerization interface [polypeptide binding]; other site 62977006634 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 62977006635 Na binding site [ion binding]; other site 62977006636 coenzyme PQQ synthesis protein PqqA; Provisional; Region: pqqA; PRK00284 62977006637 pyrroloquinoline quinone biosynthesis protein PqqB; Provisional; Region: PRK05184 62977006638 coenzyme PQQ biosynthesis protein B; Region: PQQ_syn_pqqB; TIGR02108 62977006639 pyrroloquinoline quinone biosynthesis protein PqqC; Provisional; Region: PRK05157 62977006640 pyrroloquinoline quinone biosynthesis protein PqqD; Provisional; Region: PRK02079 62977006641 pyrroloquinoline quinone biosynthesis protein PqqE; Provisional; Region: PRK05301 62977006642 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 62977006643 FeS/SAM binding site; other site 62977006644 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 62977006645 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 62977006646 renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301 62977006647 active site 62977006648 dimer interface [polypeptide binding]; other site 62977006649 3-hydroxybutyrate dehydrogenase; Provisional; Region: PRK12429 62977006650 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 62977006651 NAD(P) binding site [chemical binding]; other site 62977006652 active site 62977006653 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 62977006654 Transcriptional regulator [Transcription]; Region: LysR; COG0583 62977006655 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 62977006656 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 62977006657 putative dimerization interface [polypeptide binding]; other site 62977006658 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 62977006659 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 62977006660 Short chain fatty acids transporter [Lipid metabolism]; Region: AtoE; COG2031 62977006661 acetyl-CoA acetyltransferase; Provisional; Region: PRK06954 62977006662 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 62977006663 dimer interface [polypeptide binding]; other site 62977006664 active site 62977006665 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 62977006666 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 62977006667 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 62977006668 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 62977006669 Biotin carboxyl carrier protein [Lipid metabolism]; Region: AccB; COG0511 62977006670 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 62977006671 carboxyltransferase (CT) interaction site; other site 62977006672 biotinylation site [posttranslational modification]; other site 62977006673 Allophanate hydrolase subunit 1; Region: AHS1; smart00796 62977006674 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896 62977006675 Allophanate hydrolase subunit 2; Region: AHS2; smart00797 62977006676 hypothetical protein; Provisional; Region: PRK05463 62977006677 LamB/YcsF family of lactam utilization protein; Region: LamB_YcsF_like; cd10787 62977006678 putative active site [active] 62977006679 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 62977006680 Transcriptional regulator [Transcription]; Region: LysR; COG0583 62977006681 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 62977006682 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 62977006683 dimerization interface [polypeptide binding]; other site 62977006684 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 62977006685 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 62977006686 DNA-binding site [nucleotide binding]; DNA binding site 62977006687 Transcriptional regulators [Transcription]; Region: FadR; COG2186 62977006688 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 62977006689 DNA-binding site [nucleotide binding]; DNA binding site 62977006690 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 62977006691 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 62977006692 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 62977006693 Conserved region in glutamate synthase; Region: Glu_synthase; pfam01645 62977006694 active site 62977006695 FMN binding site [chemical binding]; other site 62977006696 substrate binding site [chemical binding]; other site 62977006697 3Fe-4S cluster binding site [ion binding]; other site 62977006698 GXGXG domain. This domain of unknown function is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS), in subunit C of tungsten formylmethanofuran dehydrogenase (FwdC) and in subunit C of molybdenum formylmethanofuran...; Region: GXGXG; cd00504 62977006699 domain_subunit interface; other site 62977006700 Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319 62977006701 Glutamine amidotransferases class-II (Gn-AT)_GlxB-type. GlxB is a glutamine amidotransferase-like protein of unknown function found in bacteria and archaea. GlxB has a structural fold similar to that of other class II glutamine amidotransferases...; Region: GlxB; cd01907 62977006702 putative active site [active] 62977006703 glutamine synthetase, type III; Region: gln_synth_III; TIGR03105 62977006704 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 62977006705 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 62977006706 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 62977006707 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 62977006708 non-specific DNA binding site [nucleotide binding]; other site 62977006709 salt bridge; other site 62977006710 sequence-specific DNA binding site [nucleotide binding]; other site 62977006711 Cupin domain; Region: Cupin_2; pfam07883 62977006712 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 62977006713 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 62977006714 putative substrate translocation pore; other site 62977006715 Transcriptional regulator [Transcription]; Region: LysR; COG0583 62977006716 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 62977006717 LysR substrate binding domain; Region: LysR_substrate; pfam03466 62977006718 dimerization interface [polypeptide binding]; other site 62977006719 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 62977006720 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 62977006721 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 62977006722 putative substrate translocation pore; other site 62977006723 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 62977006724 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 62977006725 active site 62977006726 non-prolyl cis peptide bond; other site 62977006727 Dibenzothiophene (DBT) desulfurization enzyme C; Region: DszC; cd01163 62977006728 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 62977006729 Flavin binding site [chemical binding]; other site 62977006730 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 62977006731 succinic semialdehyde dehydrogenase; Region: PLN02278 62977006732 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 62977006733 tetramerization interface [polypeptide binding]; other site 62977006734 NAD(P) binding site [chemical binding]; other site 62977006735 catalytic residues [active] 62977006736 Phosphate-selective porin O and P; Region: Porin_O_P; pfam07396 62977006737 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 62977006738 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 62977006739 Na binding site [ion binding]; other site 62977006740 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 62977006741 Uncharacterized Candidatus pelagibacter aldehyde dehydrogenase, DhaS-like; Region: ALDH_DhaS; cd07114 62977006742 NAD(P) binding site [chemical binding]; other site 62977006743 catalytic residues [active] 62977006744 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 62977006745 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 62977006746 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 62977006747 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 62977006748 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 62977006749 Amino acid synthesis; Region: AA_synth; pfam06684 62977006750 Transcriptional regulators [Transcription]; Region: GntR; COG1802 62977006751 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 62977006752 DNA-binding site [nucleotide binding]; DNA binding site 62977006753 FCD domain; Region: FCD; pfam07729 62977006754 Uncharacterized conserved protein [Function unknown]; Region: COG5470 62977006755 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 62977006756 sarcosine oxidase, alpha subunit family, heterotetrameric form; Region: soxA; TIGR01372 62977006757 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510 62977006758 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 62977006759 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 62977006760 Sarcosine oxidase, delta subunit family; Region: SoxD; pfam04267 62977006761 sarcosine oxidase, beta subunit family, heterotetrameric form; Region: soxB; TIGR01373 62977006762 hydroxyglutarate oxidase; Provisional; Region: PRK11728 62977006763 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14194 62977006764 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 62977006765 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 62977006766 homodimer interface [polypeptide binding]; other site 62977006767 NADP binding site [chemical binding]; other site 62977006768 substrate binding site [chemical binding]; other site 62977006769 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 62977006770 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 62977006771 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 62977006772 putative active site [active] 62977006773 putative substrate binding site [chemical binding]; other site 62977006774 putative cosubstrate binding site; other site 62977006775 catalytic site [active] 62977006776 Nitronate monooxygenase; Region: NMO; pfam03060 62977006777 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 62977006778 FMN binding site [chemical binding]; other site 62977006779 substrate binding site [chemical binding]; other site 62977006780 putative catalytic residue [active] 62977006781 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 62977006782 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 62977006783 FMN binding site [chemical binding]; other site 62977006784 active site 62977006785 catalytic residues [active] 62977006786 substrate binding site [chemical binding]; other site 62977006787 Protein of unknown function (DUF1615); Region: DUF1615; pfam07759 62977006788 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 62977006789 gamma-glutamyl kinase; Provisional; Region: PRK05429 62977006790 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 62977006791 nucleotide binding site [chemical binding]; other site 62977006792 homotetrameric interface [polypeptide binding]; other site 62977006793 putative phosphate binding site [ion binding]; other site 62977006794 putative allosteric binding site; other site 62977006795 PUA domain; Region: PUA; pfam01472 62977006796 GTPase CgtA; Reviewed; Region: obgE; PRK12298 62977006797 GTP1/OBG; Region: GTP1_OBG; pfam01018 62977006798 Obg GTPase; Region: Obg; cd01898 62977006799 G1 box; other site 62977006800 GTP/Mg2+ binding site [chemical binding]; other site 62977006801 Switch I region; other site 62977006802 G2 box; other site 62977006803 G3 box; other site 62977006804 Switch II region; other site 62977006805 G4 box; other site 62977006806 G5 box; other site 62977006807 glyceraldehyde-3-phosphate dehydrogenase; Reviewed; Region: PRK08289 62977006808 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 62977006809 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 62977006810 Predicted permeases [General function prediction only]; Region: RarD; COG2962 62977006811 Lipocalin-like domain; Region: Lipocalin_2; pfam08212 62977006812 excinuclease ABC subunit B; Provisional; Region: PRK05298 62977006813 Myosin and Kinesin motor domain. These ATPases belong to the P-loop NTPase family and provide the driving force in myosin and kinesin mediated processes; Region: Motor_domain; cl00286 62977006814 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 62977006815 ATP-binding site [chemical binding]; other site 62977006816 ATP binding site [chemical binding]; other site 62977006817 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 62977006818 nucleotide binding region [chemical binding]; other site 62977006819 ATP-binding site [chemical binding]; other site 62977006820 Ultra-violet resistance protein B; Region: UvrB; pfam12344 62977006821 UvrB/uvrC motif; Region: UVR; pfam02151 62977006822 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 62977006823 NAD(P) binding site [chemical binding]; other site 62977006824 active site 62977006825 hypothetical protein; Region: PHA00684 62977006826 PAS domain; Region: PAS_9; pfam13426 62977006827 PAS domain; Region: PAS_9; pfam13426 62977006828 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 62977006829 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 62977006830 metal binding site [ion binding]; metal-binding site 62977006831 active site 62977006832 I-site; other site 62977006833 aspartate aminotransferase; Provisional; Region: PRK05764 62977006834 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 62977006835 pyridoxal 5'-phosphate binding site [chemical binding]; other site 62977006836 homodimer interface [polypeptide binding]; other site 62977006837 catalytic residue [active] 62977006838 MiaE tRNA-modifying nonheme diiron monooxygenase, ferritin-like diiron-binding domain; Region: MiaE; cd07910 62977006839 active site 62977006840 dinuclear metal binding site [ion binding]; other site 62977006841 dimerization interface [polypeptide binding]; other site 62977006842 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003 62977006843 active site 62977006844 hydrophilic channel; other site 62977006845 dimerization interface [polypeptide binding]; other site 62977006846 catalytic residues [active] 62977006847 active site lid [active] 62977006848 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 62977006849 Recombination protein O N terminal; Region: RecO_N; pfam11967 62977006850 Recombination protein O C terminal; Region: RecO_C; pfam02565 62977006851 GTPase Era; Reviewed; Region: era; PRK00089 62977006852 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 62977006853 G1 box; other site 62977006854 GTP/Mg2+ binding site [chemical binding]; other site 62977006855 Switch I region; other site 62977006856 G2 box; other site 62977006857 Switch II region; other site 62977006858 G3 box; other site 62977006859 G4 box; other site 62977006860 G5 box; other site 62977006861 KH domain; Region: KH_2; pfam07650 62977006862 ribonuclease III; Reviewed; Region: rnc; PRK00102 62977006863 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 62977006864 dimerization interface [polypeptide binding]; other site 62977006865 active site 62977006866 metal binding site [ion binding]; metal-binding site 62977006867 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 62977006868 dsRNA binding site [nucleotide binding]; other site 62977006869 signal peptidase I; Provisional; Region: PRK10861 62977006870 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 62977006871 Catalytic site [active] 62977006872 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 62977006873 GTP-binding protein LepA; Provisional; Region: PRK05433 62977006874 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 62977006875 G1 box; other site 62977006876 putative GEF interaction site [polypeptide binding]; other site 62977006877 GTP/Mg2+ binding site [chemical binding]; other site 62977006878 Switch I region; other site 62977006879 G2 box; other site 62977006880 G3 box; other site 62977006881 Switch II region; other site 62977006882 G4 box; other site 62977006883 G5 box; other site 62977006884 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 62977006885 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 62977006886 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 62977006887 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 62977006888 active site 62977006889 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 62977006890 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 62977006891 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 62977006892 protein binding site [polypeptide binding]; other site 62977006893 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 62977006894 protein binding site [polypeptide binding]; other site 62977006895 L-aspartate oxidase; Provisional; Region: PRK09077 62977006896 L-aspartate oxidase; Provisional; Region: PRK06175 62977006897 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 62977006898 thymidylate kinase; Validated; Region: tmk; PRK00698 62977006899 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 62977006900 TMP-binding site; other site 62977006901 ATP-binding site [chemical binding]; other site 62977006902 YceG-like family; Region: YceG; pfam02618 62977006903 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 62977006904 dimerization interface [polypeptide binding]; other site 62977006905 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 62977006906 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 62977006907 pyridoxal 5'-phosphate binding site [chemical binding]; other site 62977006908 catalytic residue [active] 62977006909 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 62977006910 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 62977006911 substrate binding pocket [chemical binding]; other site 62977006912 membrane-bound complex binding site; other site 62977006913 hinge residues; other site 62977006914 Serine hydrolase; Region: Ser_hydrolase; pfam06821 62977006915 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 62977006916 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 62977006917 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 62977006918 dimer interface [polypeptide binding]; other site 62977006919 conserved gate region; other site 62977006920 putative PBP binding loops; other site 62977006921 ABC-ATPase subunit interface; other site 62977006922 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 62977006923 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 62977006924 dimer interface [polypeptide binding]; other site 62977006925 conserved gate region; other site 62977006926 putative PBP binding loops; other site 62977006927 ABC-ATPase subunit interface; other site 62977006928 ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118 62977006929 ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296 62977006930 Walker A/P-loop; other site 62977006931 ATP binding site [chemical binding]; other site 62977006932 Q-loop/lid; other site 62977006933 ABC transporter signature motif; other site 62977006934 Walker B; other site 62977006935 D-loop; other site 62977006936 H-loop/switch region; other site 62977006937 TOBE-like domain; Region: TOBE_3; pfam12857 62977006938 transcriptional regulator CysB-like protein; Reviewed; Region: PRK12683 62977006939 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 62977006940 The C-terminal substrate domain of LysR-type transcriptional regulators CysB-like contains type 2 periplasmic binding fold; Region: PBP2_CysB_like; cd08413 62977006941 substrate binding site [chemical binding]; other site 62977006942 dimerization interface [polypeptide binding]; other site 62977006943 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830 62977006944 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 62977006945 active site 62977006946 substrate binding site [chemical binding]; other site 62977006947 trimer interface [polypeptide binding]; other site 62977006948 CoA binding site [chemical binding]; other site 62977006949 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE, gammaproteobacterial type; Region: rSAM_QueE_gams; TIGR04349 62977006950 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 62977006951 FeS/SAM binding site; other site 62977006952 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 62977006953 Ligand Binding Site [chemical binding]; other site 62977006954 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 62977006955 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 62977006956 catalytic triad [active] 62977006957 YceI-like domain; Region: YceI; pfam04264 62977006958 Nicotinamide/nicotinate mononucleotide adenylyltransferase of bifunctional proteins, also containing a Nudix hydrolase domain; Region: NMNAT_Nudix; cd02168 62977006959 pantetheine-phosphate adenylyltransferase, bacterial; Region: coaD_prev_kdtB; TIGR01510 62977006960 active site 62977006961 (T/H)XGH motif; other site 62977006962 enoyl-CoA hydratase; Provisional; Region: PRK06688 62977006963 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 62977006964 substrate binding site [chemical binding]; other site 62977006965 oxyanion hole (OAH) forming residues; other site 62977006966 trimer interface [polypeptide binding]; other site 62977006967 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 62977006968 dimer interface [polypeptide binding]; other site 62977006969 FMN binding site [chemical binding]; other site 62977006970 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 62977006971 dimer interface [polypeptide binding]; other site 62977006972 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 62977006973 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 62977006974 Major Facilitator Superfamily; Region: MFS_1; pfam07690 62977006975 putative substrate translocation pore; other site 62977006976 phosphoribosylformylglycinamidine synthase; Provisional; Region: PRK05297 62977006977 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 62977006978 dimerization interface [polypeptide binding]; other site 62977006979 ATP binding site [chemical binding]; other site 62977006980 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 62977006981 dimerization interface [polypeptide binding]; other site 62977006982 ATP binding site [chemical binding]; other site 62977006983 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 62977006984 putative active site [active] 62977006985 catalytic triad [active] 62977006986 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01096 62977006987 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; smart00471 62977006988 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 62977006989 RuvA N terminal domain; Region: RuvA_N; pfam01330 62977006990 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 62977006991 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 62977006992 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 62977006993 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 62977006994 Walker A motif; other site 62977006995 ATP binding site [chemical binding]; other site 62977006996 Walker B motif; other site 62977006997 arginine finger; other site 62977006998 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 62977006999 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 62977007000 active site 62977007001 TolQ protein; Region: tolQ; TIGR02796 62977007002 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 62977007003 TolR protein; Region: tolR; TIGR02801 62977007004 translocation protein TolB; Provisional; Region: tolB; PRK04922 62977007005 TolB amino-terminal domain; Region: TolB_N; pfam04052 62977007006 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 62977007007 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 62977007008 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 62977007009 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 62977007010 ligand binding site [chemical binding]; other site 62977007011 fructose-1,6-bisphosphatase family protein; Region: PLN02628 62977007012 Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354 62977007013 AMP binding site [chemical binding]; other site 62977007014 metal binding site [ion binding]; metal-binding site 62977007015 active site 62977007016 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 62977007017 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 62977007018 RNA polymerase factor sigma-70; Validated; Region: PRK09047 62977007019 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 62977007020 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 62977007021 DNA binding residues [nucleotide binding] 62977007022 Protein of unknown function (DUF3106); Region: DUF3106; pfam11304 62977007023 CSLREA domain; Region: CSLREA_Nterm; TIGR04214 62977007024 Acinetobacter rhombotarget A; Region: GlyGly_RbtA; TIGR04212 62977007025 ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593 62977007026 DnaA regulatory inactivator Hda; Region: DnaA_homol_Hda; TIGR03420 62977007027 Walker A motif; other site 62977007028 ATP binding site [chemical binding]; other site 62977007029 Walker B motif; other site 62977007030 arginine finger; other site 62977007031 Domain of unknown function DUF20; Region: UPF0118; pfam01594 62977007032 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 62977007033 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 62977007034 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 62977007035 dimerization interface [polypeptide binding]; other site 62977007036 putative ATP binding site [chemical binding]; other site 62977007037 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 62977007038 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 62977007039 active site 62977007040 substrate binding site [chemical binding]; other site 62977007041 cosubstrate binding site; other site 62977007042 catalytic site [active] 62977007043 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 62977007044 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 62977007045 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 62977007046 tandem repeat interface [polypeptide binding]; other site 62977007047 oligomer interface [polypeptide binding]; other site 62977007048 active site residues [active] 62977007049 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 62977007050 putative acyl-acceptor binding pocket; other site 62977007051 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 62977007052 DNA internalization-related competence protein ComEC/Rec2; Region: ComEC_Rec2; TIGR00361 62977007053 Competence protein; Region: Competence; pfam03772 62977007054 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 62977007055 lipoprotein releasing system, ATP-binding protein; Region: LolD_lipo_ex; TIGR02211 62977007056 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 62977007057 Walker A/P-loop; other site 62977007058 ATP binding site [chemical binding]; other site 62977007059 Q-loop/lid; other site 62977007060 ABC transporter signature motif; other site 62977007061 Walker B; other site 62977007062 D-loop; other site 62977007063 H-loop/switch region; other site 62977007064 lipoprotein releasing system, transmembrane protein, LolC/E family; Region: lolCE; TIGR02212 62977007065 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 62977007066 FtsX-like permease family; Region: FtsX; pfam02687 62977007067 putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272 62977007068 EamA-like transporter family; Region: EamA; pfam00892 62977007069 EamA-like transporter family; Region: EamA; pfam00892 62977007070 Uncharacterized BCR, YaiI/YqxD family COG1671; Region: DUF188; pfam02639 62977007071 Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT). PSAT is active as...; Region: PSAT_like; cd00611 62977007072 homodimer interface [polypeptide binding]; other site 62977007073 substrate-cofactor binding pocket; other site 62977007074 pyridoxal 5'-phosphate binding site [chemical binding]; other site 62977007075 catalytic residue [active] 62977007076 Outer membrane efflux protein; Region: OEP; pfam02321 62977007077 Outer membrane efflux protein; Region: OEP; pfam02321 62977007078 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 62977007079 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 62977007080 HlyD family secretion protein; Region: HlyD_3; pfam13437 62977007081 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 62977007082 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 62977007083 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 62977007084 ABC-2 type transporter; Region: ABC2_membrane; cl17235 62977007085 DNA gyrase subunit A; Validated; Region: PRK05560 62977007086 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 62977007087 CAP-like domain; other site 62977007088 active site 62977007089 primary dimer interface [polypeptide binding]; other site 62977007090 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 62977007091 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 62977007092 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 62977007093 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 62977007094 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 62977007095 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 62977007096 DinB family; Region: DinB; cl17821 62977007097 DinB superfamily; Region: DinB_2; pfam12867 62977007098 electron transfer flavoprotein subunit alpha; Provisional; Region: PLN00022 62977007099 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 62977007100 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 62977007101 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 62977007102 Ligand binding site [chemical binding]; other site 62977007103 Electron transfer flavoprotein domain; Region: ETF; pfam01012 62977007104 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 62977007105 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 62977007106 active site 62977007107 DNA binding site [nucleotide binding] 62977007108 Int/Topo IB signature motif; other site 62977007109 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 62977007110 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 62977007111 catalytic site [active] 62977007112 TAP-like protein; Region: Abhydrolase_4; pfam08386 62977007113 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 62977007114 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 62977007115 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 62977007116 diaminopimelate decarboxylase; Region: lysA; TIGR01048 62977007117 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 62977007118 active site 62977007119 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 62977007120 substrate binding site [chemical binding]; other site 62977007121 catalytic residues [active] 62977007122 dimer interface [polypeptide binding]; other site 62977007123 Prokaryotic lipoprotein-attachment site; Region: LPAM_2; pfam13627 62977007124 D-alanine/D-serine/glycine permease; Provisional; Region: PRK11049 62977007125 DNA repair protein RadA; Provisional; Region: PRK11823 62977007126 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 62977007127 Walker A motif/ATP binding site; other site 62977007128 ATP binding site [chemical binding]; other site 62977007129 Walker B motif; other site 62977007130 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 62977007131 Tim44 is an essential component of the machinery that mediates the translocation of nuclear-encoded proteins across the mitochondrial inner membrane; Region: Tim44; smart00978 62977007132 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 62977007133 EF-P lysine aminoacylase GenX; Region: genX; TIGR00462 62977007134 motif 1; other site 62977007135 dimer interface [polypeptide binding]; other site 62977007136 active site 62977007137 motif 2; other site 62977007138 motif 3; other site 62977007139 erythronate-4-phosphate dehydrogenase; Validated; Region: PRK00257 62977007140 D-Erythronate-4-Phosphate Dehydrogenase NAD-binding and catalytic domains; Region: ErythrP_dh; cd12158 62977007141 ligand binding site [chemical binding]; other site 62977007142 NAD binding site [chemical binding]; other site 62977007143 catalytic site [active] 62977007144 homodimer interface [polypeptide binding]; other site 62977007145 anthranilate 1,2-dioxygenase, large subunit; Region: anthran_1_2_A; TIGR03228 62977007146 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 62977007147 [2Fe-2S] cluster binding site [ion binding]; other site 62977007148 C-terminal catalytic domain of the oxygenase alpha subunit of Pseudomonas resinovorans strain CA10 anthranilate 1,2-dioxygenase and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_AntDO-like; cd08879 62977007149 putative alpha subunit interface [polypeptide binding]; other site 62977007150 putative active site [active] 62977007151 putative substrate binding site [chemical binding]; other site 62977007152 Fe binding site [ion binding]; other site 62977007153 Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667 62977007154 inter-subunit interface; other site 62977007155 anthranilate dioxygenase reductase; Provisional; Region: antC; PRK11872 62977007156 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 62977007157 catalytic loop [active] 62977007158 iron binding site [ion binding]; other site 62977007159 Benzoate dioxygenase reductase (BenDO) FAD/NAD binding domain. Oxygenases oxidize hydrocarbons using dioxygen as the oxidant. As a Class I bacterial dioxygenases, benzoate dioxygenase like proteins combine an [2Fe-2S] cluster containing N-terminal...; Region: BenDO_FAD_NAD; cd06209 62977007160 FAD binding pocket [chemical binding]; other site 62977007161 FAD binding motif [chemical binding]; other site 62977007162 phosphate binding motif [ion binding]; other site 62977007163 beta-alpha-beta structure motif; other site 62977007164 NAD binding pocket [chemical binding]; other site 62977007165 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 62977007166 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 62977007167 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 62977007168 Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; cl01768 62977007169 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 62977007170 short chain dehydrogenase; Provisional; Region: PRK08265 62977007171 classical (c) SDRs; Region: SDR_c; cd05233 62977007172 NAD(P) binding site [chemical binding]; other site 62977007173 active site 62977007174 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 62977007175 Helix-turn-helix domain; Region: HTH_18; pfam12833 62977007176 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 62977007177 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 62977007178 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 62977007179 NAD(P) binding site [chemical binding]; other site 62977007180 PAAR motif; Region: PAAR_motif; pfam05488 62977007181 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 62977007182 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 62977007183 ligand binding site [chemical binding]; other site 62977007184 type VI secretion-associated protein, BMA_A0400 family; Region: VI_minor_4; TIGR03373 62977007185 Type VI protein secretion system component VasK [Intracellular trafficking, secretion, and vesicular transport]; Region: IcmF; COG3523 62977007186 Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761 62977007187 Protein of unknown function (DUF1215); Region: DUF1215; pfam06744 62977007188 Protein of unknown function (DUF1305); Region: DUF1305; pfam06996 62977007189 Type VI protein secretion system component VasA [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3519 62977007190 type VI secretion protein, VC_A0110 family; Region: VI_chp_6; TIGR03359 62977007191 type VI secretion system lysozyme-like protein; Region: VI_zyme; TIGR03357 62977007192 Protein of unknown function (DUF796); Region: DUF796; pfam05638 62977007193 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3517; cl05484 62977007194 Protein of unknown function (DUF877); Region: DUF877; pfam05943 62977007195 Protein of unknown function (DUF770); Region: DUF770; pfam05591 62977007196 type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345 62977007197 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 62977007198 Walker A motif; other site 62977007199 ATP binding site [chemical binding]; other site 62977007200 Walker B motif; other site 62977007201 arginine finger; other site 62977007202 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 62977007203 Walker A motif; other site 62977007204 ATP binding site [chemical binding]; other site 62977007205 Walker B motif; other site 62977007206 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 62977007207 type VI secretion-associated protein, ImpA family; Region: VI_chp_8; TIGR03363 62977007208 ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812 62977007209 type VI secretion protein, VC_A0114 family; Region: VI_chp_4; TIGR03353 62977007210 Bacterial protein of unknown function (DUF876); Region: DUF876; pfam05936 62977007211 type IV / VI secretion system protein, DotU family; Region: IV_VI_DotU; TIGR03349 62977007212 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 62977007213 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_M15_4; pfam13539 62977007214 probable AcnD-accessory protein PrpF; Region: prpF; TIGR02334 62977007215 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 62977007216 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 62977007217 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 62977007218 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 62977007219 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 62977007220 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 62977007221 hypothetical protein; Provisional; Region: PRK07236 62977007222 multidrug efflux system protein EmrA; Provisional; Region: PRK15136 62977007223 Isochorismatase family; Region: Isochorismatase; pfam00857 62977007224 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 62977007225 catalytic triad [active] 62977007226 conserved cis-peptide bond; other site 62977007227 Pirin-related protein [General function prediction only]; Region: COG1741 62977007228 Pirin; Region: Pirin; pfam02678 62977007229 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 62977007230 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 62977007231 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 62977007232 FMN binding site [chemical binding]; other site 62977007233 active site 62977007234 substrate binding site [chemical binding]; other site 62977007235 catalytic residue [active] 62977007236 Transcriptional regulator [Transcription]; Region: LysR; COG0583 62977007237 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 62977007238 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 62977007239 putative effector binding pocket; other site 62977007240 dimerization interface [polypeptide binding]; other site 62977007241 Y-family of DNA polymerases; Region: PolY; cl12025 62977007242 active site 62977007243 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 62977007244 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 62977007245 Catalytic site [active] 62977007246 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 62977007247 CoenzymeA binding site [chemical binding]; other site 62977007248 subunit interaction site [polypeptide binding]; other site 62977007249 PHB binding site; other site 62977007250 Protein of unknown function (DUF330); Region: DUF330; pfam03886 62977007251 Paraquat-inducible protein B [General function prediction only]; Region: PqiB; COG3008 62977007252 mce related protein; Region: MCE; pfam02470 62977007253 mce related protein; Region: MCE; pfam02470 62977007254 mce related protein; Region: MCE; pfam02470 62977007255 Paraquat-inducible protein A; Region: PqiA; pfam04403 62977007256 Paraquat-inducible protein A; Region: PqiA; pfam04403 62977007257 2-enoyl thioester reductase (ETR) like proteins, child 2; Region: ETR_like_2; cd08292 62977007258 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 62977007259 putative NAD(P) binding site [chemical binding]; other site 62977007260 putative dimer interface [polypeptide binding]; other site 62977007261 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 62977007262 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 62977007263 potential catalytic triad [active] 62977007264 conserved cys residue [active] 62977007265 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 62977007266 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 62977007267 Transcriptional regulator [Transcription]; Region: LysR; COG0583 62977007268 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 62977007269 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 62977007270 putative effector binding pocket; other site 62977007271 dimerization interface [polypeptide binding]; other site 62977007272 LysE type translocator; Region: LysE; cl00565 62977007273 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 62977007274 Sel1-like repeats; Region: SEL1; smart00671 62977007275 Sel1-like repeats; Region: SEL1; smart00671 62977007276 Sel1-like repeats; Region: SEL1; smart00671 62977007277 Sel1-like repeats; Region: SEL1; smart00671 62977007278 Sel1-like repeats; Region: SEL1; smart00671 62977007279 phosphonate utilization associated putative membrane protein; Region: phn_DUF6; TIGR03340 62977007280 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 62977007281 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 62977007282 TAP-like protein; Region: Abhydrolase_4; pfam08386 62977007283 hypothetical protein; Provisional; Region: PRK11032 62977007284 Protein of unknown function (DUF2569); Region: DUF2569; pfam10754 62977007285 2-methylisocitrate dehydratase, Fe/S-dependent; Region: 2met_isocit_dHY; TIGR02333 62977007286 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 62977007287 substrate binding site [chemical binding]; other site 62977007288 ligand binding site [chemical binding]; other site 62977007289 Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215 62977007290 substrate binding site [chemical binding]; other site 62977007291 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 62977007292 methylcitrate synthase; Provisional; Region: PRK12351 62977007293 oxalacetate binding site [chemical binding]; other site 62977007294 citrylCoA binding site [chemical binding]; other site 62977007295 coenzyme A binding site [chemical binding]; other site 62977007296 catalytic triad [active] 62977007297 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 62977007298 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 62977007299 tetramer interface [polypeptide binding]; other site 62977007300 active site 62977007301 Mg2+/Mn2+ binding site [ion binding]; other site 62977007302 Transcriptional regulators [Transcription]; Region: GntR; COG1802 62977007303 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 62977007304 DNA-binding site [nucleotide binding]; DNA binding site 62977007305 FCD domain; Region: FCD; pfam07729 62977007306 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 62977007307 putative efflux protein, MATE family; Region: matE; TIGR00797 62977007308 cation binding site [ion binding]; other site 62977007309 Protein of unknown function (DUF2470); Region: DUF2470; pfam10615 62977007310 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 62977007311 FAD binding pocket [chemical binding]; other site 62977007312 FAD binding motif [chemical binding]; other site 62977007313 phosphate binding motif [ion binding]; other site 62977007314 NAD binding pocket [chemical binding]; other site 62977007315 muropeptide transporter; Validated; Region: ampG; cl17669 62977007316 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 62977007317 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 62977007318 N-terminal plug; other site 62977007319 ligand-binding site [chemical binding]; other site 62977007320 Thioesterase domain; Region: Thioesterase; pfam00975 62977007321 phosphopantetheinyltransferase component of enterobactin synthase multienzyme complex; Provisional; Region: PRK10251 62977007322 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 62977007323 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 62977007324 Siderophore biosynthesis protein domain; Region: AlcB; smart01006 62977007325 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 62977007326 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Ornithine Decarboxylase; Region: PLPDE_III_ODC; cd00622 62977007327 dimer interface [polypeptide binding]; other site 62977007328 active site 62977007329 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 62977007330 catalytic residues [active] 62977007331 substrate binding site [chemical binding]; other site 62977007332 L-lysine 6-monooxygenase (NADPH-requiring); Region: K_oxygenase; pfam13434 62977007333 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 62977007334 Peptide arylation enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntE; COG1021 62977007335 2,3-dihydroxybenzoate-AMP ligase; Region: 23DHB-AMP_lg; cd05920 62977007336 acyl-activating enzyme (AAE) consensus motif; other site 62977007337 active site 62977007338 AMP binding site [chemical binding]; other site 62977007339 substrate binding site [chemical binding]; other site 62977007340 Condensation domain; Region: Condensation; pfam00668 62977007341 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 62977007342 Condensation domain; Region: Condensation; pfam00668 62977007343 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 62977007344 Condensation domain; Region: Condensation; pfam00668 62977007345 Nonribosomal peptide synthase; Region: NRPS; pfam08415 62977007346 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; Region: A_NRPS_TlmIV_like; cd12114 62977007347 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 62977007348 acyl-activating enzyme (AAE) consensus motif; other site 62977007349 AMP binding site [chemical binding]; other site 62977007350 Phosphopantetheine attachment site; Region: PP-binding; cl09936 62977007351 Condensation domain; Region: Condensation; pfam00668 62977007352 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 62977007353 Nonribosomal peptide synthase; Region: NRPS; pfam08415 62977007354 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 62977007355 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 62977007356 2,3-dihydroxybenzoate-2,3-dehydrogenase; Validated; Region: PRK08220 62977007357 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 62977007358 NAD(P) binding site [chemical binding]; other site 62977007359 active site 62977007360 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 62977007361 Isochorismatase family; Region: Isochorismatase; pfam00857 62977007362 catalytic triad [active] 62977007363 conserved cis-peptide bond; other site 62977007364 isochorismate synthase DhbC; Validated; Region: PRK06923 62977007365 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 62977007366 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 62977007367 Integrase core domain; Region: rve_2; pfam13333 62977007368 Integrase core domain; Region: rve; pfam00665 62977007369 putative transposase OrfB; Reviewed; Region: PHA02517 62977007370 haemagglutination activity domain; Region: Haemagg_act; pfam05860 62977007371 Possible hemagglutinin (DUF637); Region: DUF637; pfam04830 62977007372 Pre-toxin domain with VENN motif; Region: PT-VENN; pfam04829 62977007373 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 62977007374 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 62977007375 Haemolysin secretion/activation protein ShlB/FhaC/HecB; Region: ShlB; pfam03865 62977007376 Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; cl17479 62977007377 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 62977007378 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 62977007379 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 62977007380 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 62977007381 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 62977007382 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 62977007383 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 62977007384 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 62977007385 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 62977007386 YqaJ-like viral recombinase domain; Region: YqaJ; pfam09588 62977007387 phage/plasmid-like protein TIGR03299; Region: LGT_TIGR03299 62977007388 Protein of unknown function (DUF805); Region: DUF805; pfam05656 62977007389 transcription elongation factor GreB; Reviewed; Region: greB; PRK01885 62977007390 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 62977007391 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 62977007392 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 62977007393 Transcriptional regulator [Transcription]; Region: IclR; COG1414 62977007394 Bacterial transcriptional regulator; Region: IclR; pfam01614 62977007395 H+/citrate symporter [Energy production and conversion]; Region: CitM; cl17620 62977007396 Citrate transporter; Region: CitMHS; pfam03600 62977007397 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 62977007398 NHL repeat; Region: NHL; pfam01436 62977007399 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 62977007400 active site 62977007401 catalytic residues [active] 62977007402 metal binding site [ion binding]; metal-binding site 62977007403 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 62977007404 CoA-transferase family III; Region: CoA_transf_3; pfam02515 62977007405 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 62977007406 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 62977007407 putative substrate translocation pore; other site 62977007408 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 62977007409 transcription elongation factor GreB; Reviewed; Region: greB; PRK01885 62977007410 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 62977007411 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 62977007412 N-acetyl-D-glucosamine binding site [chemical binding]; other site 62977007413 catalytic residue [active] 62977007414 SCP-2 sterol transfer family; Region: SCP2; pfam02036 62977007415 tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696 62977007416 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 62977007417 Ligand Binding Site [chemical binding]; other site 62977007418 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 62977007419 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 62977007420 N-acetyl-D-glucosamine binding site [chemical binding]; other site 62977007421 catalytic residue [active] 62977007422 heat shock protein HtpX; Provisional; Region: PRK05457 62977007423 Domain of unknown function (DUF4112); Region: DUF4112; pfam13430 62977007424 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 62977007425 MgtE intracellular N domain; Region: MgtE_N; pfam03448 62977007426 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 62977007427 Divalent cation transporter; Region: MgtE; pfam01769 62977007428 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 62977007429 Protein export membrane protein; Region: SecD_SecF; cl14618 62977007430 Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818 62977007431 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 62977007432 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 62977007433 ring oligomerisation interface [polypeptide binding]; other site 62977007434 ATP/Mg binding site [chemical binding]; other site 62977007435 stacking interactions; other site 62977007436 hinge regions; other site 62977007437 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 62977007438 oligomerisation interface [polypeptide binding]; other site 62977007439 mobile loop; other site 62977007440 roof hairpin; other site 62977007441 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 62977007442 Bacillus subtilis YydB and related proteins, metallophosphatase domain; Region: MPP_YydB; cd07400 62977007443 putative active site [active] 62977007444 putative metal binding site [ion binding]; other site 62977007445 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 62977007446 active site 62977007447 metal binding site [ion binding]; metal-binding site 62977007448 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 62977007449 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 62977007450 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819 62977007451 active site 62977007452 substrate-binding site [chemical binding]; other site 62977007453 metal-binding site [ion binding] 62977007454 GTP binding site [chemical binding]; other site 62977007455 glycerol-3-phosphate dehydrogenase; Reviewed; Region: glpD; PRK12266 62977007456 Predicted methyltransferase [General function prediction only]; Region: COG3897 62977007457 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 62977007458 S-adenosylmethionine binding site [chemical binding]; other site 62977007459 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14192 62977007460 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 62977007461 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 62977007462 homodimer interface [polypeptide binding]; other site 62977007463 NADP binding site [chemical binding]; other site 62977007464 substrate binding site [chemical binding]; other site 62977007465 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 62977007466 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 62977007467 dihydropteroate synthase; Region: DHPS; TIGR01496 62977007468 substrate binding pocket [chemical binding]; other site 62977007469 dimer interface [polypeptide binding]; other site 62977007470 inhibitor binding site; inhibition site 62977007471 FtsH Extracellular; Region: FtsH_ext; pfam06480 62977007472 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 62977007473 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 62977007474 Walker A motif; other site 62977007475 ATP binding site [chemical binding]; other site 62977007476 Walker B motif; other site 62977007477 arginine finger; other site 62977007478 Peptidase family M41; Region: Peptidase_M41; pfam01434 62977007479 FtsJ-like methyltransferase; Region: FtsJ; cl17430 62977007480 23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293 62977007481 CRS1 / YhbY (CRM) domain; Region: CRS1_YhbY; pfam01985 62977007482 Domon-like domain of UDP-N-acetylenolpyruvoylglucosamine reductase; Region: DOMON_murB_like; cd09627 62977007483 putative heme binding site [chemical binding]; other site 62977007484 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 62977007485 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 62977007486 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 62977007487 catalytic site [active] 62977007488 subunit interface [polypeptide binding]; other site 62977007489 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 62977007490 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 62977007491 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 62977007492 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 62977007493 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 62977007494 ATP-grasp domain; Region: ATP-grasp_4; cl17255 62977007495 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 62977007496 IMP binding site; other site 62977007497 dimer interface [polypeptide binding]; other site 62977007498 interdomain contacts; other site 62977007499 partial ornithine binding site; other site 62977007500 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 62977007501 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 62977007502 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 62977007503 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 62977007504 Ligand Binding Site [chemical binding]; other site 62977007505 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 62977007506 DNA binding site [nucleotide binding] 62977007507 active site 62977007508 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 62977007509 Ligand Binding Site [chemical binding]; other site 62977007510 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 62977007511 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 62977007512 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 62977007513 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 62977007514 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 62977007515 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 62977007516 type I secretion C-terminal target domain (VC_A0849 subclass); Region: T1SS_VCA0849; TIGR03661 62977007517 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 62977007518 Predicted metalloprotease [General function prediction only]; Region: COG2321 62977007519 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 62977007520 Protein of unknown function (DUF808); Region: DUF808; pfam05661 62977007521 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 62977007522 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 62977007523 active site 62977007524 HIGH motif; other site 62977007525 dimer interface [polypeptide binding]; other site 62977007526 KMSKS motif; other site 62977007527 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 62977007528 CoA binding domain; Region: CoA_binding; smart00881 62977007529 CoA-ligase; Region: Ligase_CoA; pfam00549 62977007530 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 62977007531 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 62977007532 CoA-ligase; Region: Ligase_CoA; pfam00549 62977007533 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06467 62977007534 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 62977007535 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 62977007536 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 62977007537 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 62977007538 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 62977007539 E3 interaction surface; other site 62977007540 lipoyl attachment site [posttranslational modification]; other site 62977007541 e3 binding domain; Region: E3_binding; pfam02817 62977007542 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 62977007543 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 62977007544 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 62977007545 TPP-binding site [chemical binding]; other site 62977007546 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 62977007547 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 62977007548 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 62977007549 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07057 62977007550 L-aspartate oxidase; Provisional; Region: PRK06175 62977007551 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 62977007552 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. E. coli SQR, a member of this subfamily, reduces the...; Region: SQR_TypeC_SdhD; cd03494 62977007553 SdhC subunit interface [polypeptide binding]; other site 62977007554 proximal heme binding site [chemical binding]; other site 62977007555 cardiolipin binding site; other site 62977007556 Iron-sulfur protein interface; other site 62977007557 proximal quinone binding site [chemical binding]; other site 62977007558 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499 62977007559 Iron-sulfur protein interface; other site 62977007560 proximal quinone binding site [chemical binding]; other site 62977007561 SdhD (CybS) interface [polypeptide binding]; other site 62977007562 proximal heme binding site [chemical binding]; other site 62977007563 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 62977007564 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 62977007565 dimer interface [polypeptide binding]; other site 62977007566 active site 62977007567 citrylCoA binding site [chemical binding]; other site 62977007568 NADH binding [chemical binding]; other site 62977007569 cationic pore residues; other site 62977007570 oxalacetate/citrate binding site [chemical binding]; other site 62977007571 coenzyme A binding site [chemical binding]; other site 62977007572 catalytic triad [active] 62977007573 NAD synthetase; Provisional; Region: PRK13981 62977007574 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 62977007575 multimer interface [polypeptide binding]; other site 62977007576 active site 62977007577 catalytic triad [active] 62977007578 protein interface 1 [polypeptide binding]; other site 62977007579 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 62977007580 homodimer interface [polypeptide binding]; other site 62977007581 NAD binding pocket [chemical binding]; other site 62977007582 ATP binding pocket [chemical binding]; other site 62977007583 Mg binding site [ion binding]; other site 62977007584 active-site loop [active] 62977007585 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 62977007586 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 62977007587 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 62977007588 active site 62977007589 (T/H)XGH motif; other site 62977007590 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 62977007591 SmpB-tmRNA interface; other site 62977007592 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 62977007593 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 62977007594 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 62977007595 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 62977007596 23S rRNA pseudouridine synthase D; Provisional; Region: rluD; PRK11180 62977007597 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 62977007598 RNA binding surface [nucleotide binding]; other site 62977007599 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 62977007600 active site 62977007601 outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302 62977007602 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 62977007603 binding surface 62977007604 TPR motif; other site 62977007605 DNA primase, catalytic core; Region: dnaG; TIGR01391 62977007606 CHC2 zinc finger; Region: zf-CHC2; pfam01807 62977007607 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 62977007608 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 62977007609 active site 62977007610 metal binding site [ion binding]; metal-binding site 62977007611 interdomain interaction site; other site 62977007612 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 62977007613 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 62977007614 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 62977007615 tRNA; other site 62977007616 putative tRNA binding site [nucleotide binding]; other site 62977007617 putative NADP binding site [chemical binding]; other site 62977007618 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 62977007619 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 62977007620 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 62977007621 binding surface 62977007622 TPR motif; other site 62977007623 outer membrane lipoprotein LolB; Provisional; Region: lolB; PRK00022 62977007624 Outer membrane lipoprotein LolB; Region: LolB; pfam03550 62977007625 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00343 62977007626 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 62977007627 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 62977007628 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 62977007629 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 62977007630 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 62977007631 active site 62977007632 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 62977007633 5S rRNA interface [nucleotide binding]; other site 62977007634 CTC domain interface [polypeptide binding]; other site 62977007635 L16 interface [polypeptide binding]; other site 62977007636 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 62977007637 putative active site [active] 62977007638 catalytic residue [active] 62977007639 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 62977007640 tetramerization interface [polypeptide binding]; other site 62977007641 active site 62977007642 3,4-dihydroxy-2-butanone 4-phosphate synthase; Provisional; Region: ribB; PRK03353 62977007643 3,4-dihydroxy-2-butanone 4-phosphate synthase [Coenzyme metabolism]; Region: RibB; COG0108 62977007644 Protein of unknown function (DUF1289); Region: DUF1289; pfam06945 62977007645 Predicted sulfurtransferase [General function prediction only]; Region: COG1054 62977007646 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 62977007647 active site residue [active] 62977007648 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 62977007649 Coenzyme A binding pocket [chemical binding]; other site 62977007650 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 62977007651 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 62977007652 Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg6; cd04781 62977007653 DNA binding residues [nucleotide binding] 62977007654 Cu(I)-responsive transcriptional regulator; Region: CueR; TIGR02044 62977007655 putative dimer interface [polypeptide binding]; other site 62977007656 putative metal binding residues [ion binding]; other site 62977007657 Protein of unknown function (DUF2938); Region: DUF2938; pfam11158 62977007658 thiopurine S-methyltransferase, Se/Te detoxification family; Region: TMPT_Se_Te; TIGR03840 62977007659 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 62977007660 S-adenosylmethionine binding site [chemical binding]; other site 62977007661 Uncharacterized protein family (UPF0149); Region: UPF0149; pfam03695 62977007662 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 62977007663 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 62977007664 Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546 62977007665 RNA polymerase sigma factor RpoD, C-terminal domain; Region: RpoD_Cterm; TIGR02393 62977007666 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 62977007667 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 62977007668 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 62977007669 DNA binding residues [nucleotide binding] 62977007670 Protein of unknown function (DUF493); Region: DUF493; pfam04359 62977007671 lipoate-protein ligase B; Provisional; Region: PRK14342 62977007672 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 62977007673 Iron-containing alcohol dehydrogenases-like; Region: Fe-ADH5; cd08189 62977007674 putative active site [active] 62977007675 metal binding site [ion binding]; metal-binding site 62977007676 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 62977007677 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 62977007678 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 62977007679 Predicted transcriptional regulators [Transcription]; Region: COG1733 62977007680 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 62977007681 dimerization interface [polypeptide binding]; other site 62977007682 putative DNA binding site [nucleotide binding]; other site 62977007683 putative Zn2+ binding site [ion binding]; other site 62977007684 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 62977007685 siroheme synthase; Provisional; Region: cysG; PRK10637 62977007686 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 62977007687 Sirohaem synthase dimerisation region; Region: CysG_dimeriser; pfam10414 62977007688 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 62977007689 active site 62977007690 SAM binding site [chemical binding]; other site 62977007691 homodimer interface [polypeptide binding]; other site 62977007692 seryl-tRNA synthetase; Provisional; Region: PRK05431 62977007693 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 62977007694 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 62977007695 dimer interface [polypeptide binding]; other site 62977007696 active site 62977007697 motif 1; other site 62977007698 motif 2; other site 62977007699 motif 3; other site 62977007700 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 62977007701 lipoprotein chaperone; Reviewed; Region: lolA; PRK00031 62977007702 Outer membrane lipoprotein carrier protein LolA; Region: LolA; pfam03548 62977007703 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 62977007704 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 62977007705 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 62977007706 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 62977007707 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 62977007708 substrate binding pocket [chemical binding]; other site 62977007709 chain length determination region; other site 62977007710 substrate-Mg2+ binding site; other site 62977007711 catalytic residues [active] 62977007712 aspartate-rich region 1; other site 62977007713 active site lid residues [active] 62977007714 aspartate-rich region 2; other site 62977007715 Site-specific recombinase; Region: SpecificRecomb; pfam10136 62977007716 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 62977007717 active site 62977007718 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 62977007719 multidrug efflux system transporter AcrA; Provisional; Region: PRK15030 62977007720 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 62977007721 HlyD family secretion protein; Region: HlyD_3; pfam13437 62977007722 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 62977007723 Protein export membrane protein; Region: SecD_SecF; cl14618 62977007724 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 62977007725 hypothetical protein; Provisional; Region: PRK00967 62977007726 Uncharacterized conserved protein [Function unknown]; Region: COG0393 62977007727 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 62977007728 short chain dehydrogenase; Provisional; Region: PRK06181 62977007729 NAD(P) binding site [chemical binding]; other site 62977007730 active site 62977007731 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 62977007732 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 62977007733 HIGH motif; other site 62977007734 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 62977007735 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 62977007736 active site 62977007737 KMSKS motif; other site 62977007738 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 62977007739 tRNA binding surface [nucleotide binding]; other site 62977007740 anticodon binding site; other site 62977007741 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 62977007742 chaperone protein DnaJ; Provisional; Region: PRK14294 62977007743 Predicted permeases [General function prediction only]; Region: COG0679 62977007744 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 62977007745 PAP2_like_6 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which mainly contains bacterial proteins, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_6; cd03396 62977007746 active site 62977007747 sensor protein QseC; Provisional; Region: PRK10337 62977007748 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 62977007749 dimer interface [polypeptide binding]; other site 62977007750 phosphorylation site [posttranslational modification] 62977007751 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 62977007752 ATP binding site [chemical binding]; other site 62977007753 Mg2+ binding site [ion binding]; other site 62977007754 G-X-G motif; other site 62977007755 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 62977007756 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 62977007757 active site 62977007758 phosphorylation site [posttranslational modification] 62977007759 intermolecular recognition site; other site 62977007760 dimerization interface [polypeptide binding]; other site 62977007761 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 62977007762 DNA binding site [nucleotide binding] 62977007763 muropeptide transporter; Validated; Region: ampG; cl17669 62977007764 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 62977007765 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown ABO13168; Region: LPLAT_ABO13168-like; cd07988 62977007766 putative acyl-acceptor binding pocket; other site 62977007767 hypothetical protein; Provisional; Region: PRK10279 62977007768 Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205 62977007769 nucleophile elbow; other site 62977007770 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 62977007771 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 62977007772 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 62977007773 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 62977007774 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 62977007775 substrate binding pocket [chemical binding]; other site 62977007776 chain length determination region; other site 62977007777 substrate-Mg2+ binding site; other site 62977007778 catalytic residues [active] 62977007779 aspartate-rich region 1; other site 62977007780 active site lid residues [active] 62977007781 aspartate-rich region 2; other site 62977007782 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 62977007783 Uncharacterized protein conserved in bacteria (DUF2256); Region: DUF2256; pfam10013 62977007784 Protein of unknown function (DUF2805); Region: DUF2805; pfam10985 62977007785 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 62977007786 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 62977007787 active site 62977007788 phosphorylation site [posttranslational modification] 62977007789 intermolecular recognition site; other site 62977007790 dimerization interface [polypeptide binding]; other site 62977007791 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 62977007792 DNA binding site [nucleotide binding] 62977007793 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 62977007794 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 62977007795 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 62977007796 Ligand Binding Site [chemical binding]; other site 62977007797 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 62977007798 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 62977007799 dimer interface [polypeptide binding]; other site 62977007800 phosphorylation site [posttranslational modification] 62977007801 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 62977007802 ATP binding site [chemical binding]; other site 62977007803 Mg2+ binding site [ion binding]; other site 62977007804 G-X-G motif; other site 62977007805 potassium-transporting ATPase subunit C; Reviewed; Region: PRK00315 62977007806 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 62977007807 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 62977007808 Soluble P-type ATPase [General function prediction only]; Region: COG4087 62977007809 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 62977007810 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 62977007811 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 62977007812 putative DNA binding site [nucleotide binding]; other site 62977007813 putative Zn2+ binding site [ion binding]; other site 62977007814 AsnC family; Region: AsnC_trans_reg; pfam01037 62977007815 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 62977007816 Bacterial protein of unknown function (DUF934); Region: DUF934; pfam06073 62977007817 Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155 62977007818 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 62977007819 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 62977007820 membrane-bound PQQ-dependent dehydrogenase, glucose/quinate/shikimate family; Region: PQQ_membr_DH; TIGR03074 62977007821 Membrane-bound PQQ-dependent glucose dehydrogenase; Region: PQQ_mGDH; cd10280 62977007822 Trp docking motif [polypeptide binding]; other site 62977007823 putative active site [active] 62977007824 Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966 62977007825 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 62977007826 CoA-transferase family III; Region: CoA_transf_3; pfam02515 62977007827 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 62977007828 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 62977007829 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 62977007830 topology modulation protein; Reviewed; Region: PRK08118 62977007831 AAA domain; Region: AAA_17; pfam13207 62977007832 acetyl-CoA acetyltransferase; Validated; Region: PRK08242 62977007833 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 62977007834 dimer interface [polypeptide binding]; other site 62977007835 active site 62977007836 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 62977007837 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 62977007838 substrate binding site [chemical binding]; other site 62977007839 oxyanion hole (OAH) forming residues; other site 62977007840 trimer interface [polypeptide binding]; other site 62977007841 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 62977007842 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 62977007843 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667 62977007844 Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208 62977007845 active site 62977007846 nucleophile elbow; other site 62977007847 Bleomycin binding protein (BLMA) and similar proteins; BLMA confers bleomycin (Bm) resistance by directly binding to Bm; Region: BLMA_like; cd08349 62977007848 dimer interface [polypeptide binding]; other site 62977007849 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 62977007850 ligand binding site [chemical binding]; other site 62977007851 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 62977007852 Coenzyme A binding pocket [chemical binding]; other site 62977007853 Methyltransferase domain; Region: Methyltransf_31; pfam13847 62977007854 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 62977007855 S-adenosylmethionine binding site [chemical binding]; other site 62977007856 Haemolysin-III related; Region: HlyIII; cl03831 62977007857 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 62977007858 metabolite-proton symporter; Region: 2A0106; TIGR00883 62977007859 putative substrate translocation pore; other site 62977007860 hypothetical protein; Provisional; Region: PRK06771 62977007861 phosphodiesterase YaeI; Provisional; Region: PRK11340 62977007862 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 62977007863 putative active site [active] 62977007864 putative metal binding site [ion binding]; other site 62977007865 Putative catalytic domain, repeat 1, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_1; cd09111 62977007866 putative active site [active] 62977007867 catalytic site [active] 62977007868 Putative catalytic domain, repeat 2, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_2; cd09113 62977007869 PLD-like domain; Region: PLDc_2; pfam13091 62977007870 putative active site [active] 62977007871 catalytic site [active] 62977007872 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 62977007873 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 62977007874 putative acyl-acceptor binding pocket; other site 62977007875 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 62977007876 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 62977007877 HflX GTPase family; Region: HflX; cd01878 62977007878 G1 box; other site 62977007879 GTP/Mg2+ binding site [chemical binding]; other site 62977007880 Switch I region; other site 62977007881 G2 box; other site 62977007882 G3 box; other site 62977007883 Switch II region; other site 62977007884 G4 box; other site 62977007885 G5 box; other site 62977007886 LrgB-like family; Region: LrgB; cl00596 62977007887 diadenosine tetraphosphatase; Reviewed; Region: apaH; PRK00166 62977007888 Escherichia coli ApaH and related proteins, metallophosphatase domain; Region: MPP_ApaH; cd07422 62977007889 active site 62977007890 metal binding site [ion binding]; metal-binding site 62977007891 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 62977007892 Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030 62977007893 4-hydroxythreonine-4-phosphate dehydrogenase; Region: pdxA; TIGR00557 62977007894 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 62977007895 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 62977007896 23S rRNA interface [nucleotide binding]; other site 62977007897 L3 interface [polypeptide binding]; other site 62977007898 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 62977007899 stringent starvation protein A; Provisional; Region: sspA; PRK09481 62977007900 GST_N family, Stringent starvation protein A (SspA) subfamily; SspA is a RNA polymerase (RNAP)-associated protein required for the lytic development of phage P1 and for stationary phase-induced acid tolerance of E. coli. It is implicated in survival...; Region: GST_N_SspA; cd03059 62977007901 C-terminal domain interface [polypeptide binding]; other site 62977007902 putative GSH binding site (G-site) [chemical binding]; other site 62977007903 dimer interface [polypeptide binding]; other site 62977007904 C-terminal, alpha helical domain of Stringent starvation protein A; Region: GST_C_SspA; cd03186 62977007905 dimer interface [polypeptide binding]; other site 62977007906 N-terminal domain interface [polypeptide binding]; other site 62977007907 ClpXP protease specificity-enhancing factor; Provisional; Region: PRK11798 62977007908 VacJ like lipoprotein; Region: VacJ; cl01073 62977007909 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 62977007910 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 62977007911 anti sigma factor interaction site; other site 62977007912 regulatory phosphorylation site [posttranslational modification]; other site 62977007913 Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases); Region: nit; cd07572 62977007914 nitrilase; Region: PLN02798 62977007915 putative active site [active] 62977007916 catalytic triad [active] 62977007917 dimer interface [polypeptide binding]; other site 62977007918 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 62977007919 MarR family; Region: MarR; pfam01047 62977007920 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 62977007921 type II secretion system protein E; Region: type_II_gspE; TIGR02533 62977007922 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 62977007923 Walker A motif; other site 62977007924 ATP binding site [chemical binding]; other site 62977007925 Walker B motif; other site 62977007926 Protein of unknown function (DUF432); Region: DUF432; cl01027 62977007927 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 62977007928 Mechanosensitive ion channel; Region: MS_channel; pfam00924 62977007929 Predicted membrane protein (DUF2339); Region: DUF2339; pfam10101 62977007930 DNA polymerase I; Provisional; Region: PRK05755 62977007931 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 62977007932 active site 62977007933 metal binding site 1 [ion binding]; metal-binding site 62977007934 putative 5' ssDNA interaction site; other site 62977007935 metal binding site 3; metal-binding site 62977007936 metal binding site 2 [ion binding]; metal-binding site 62977007937 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 62977007938 putative DNA binding site [nucleotide binding]; other site 62977007939 putative metal binding site [ion binding]; other site 62977007940 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 62977007941 active site 62977007942 catalytic site [active] 62977007943 substrate binding site [chemical binding]; other site 62977007944 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 62977007945 active site 62977007946 DNA binding site [nucleotide binding] 62977007947 catalytic site [active] 62977007948 YGGT family; Region: YGGT; pfam02325 62977007949 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 62977007950 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 62977007951 tRNA(Ile)-lysidine synthetase; Provisional; Region: tilS; PRK10660 62977007952 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 62977007953 Ligand Binding Site [chemical binding]; other site 62977007954 TilS substrate binding domain; Region: TilS; pfam09179 62977007955 TilS substrate C-terminal domain; Region: TilS_C; pfam11734 62977007956 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 62977007957 guanosine pentaphosphate phosphohydrolase; Provisional; Region: PRK11031 62977007958 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 62977007959 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 62977007960 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 62977007961 catalytic residues [active] 62977007962 transcription termination factor Rho; Provisional; Region: rho; PRK09376 62977007963 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 62977007964 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 62977007965 RNA binding site [nucleotide binding]; other site 62977007966 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 62977007967 multimer interface [polypeptide binding]; other site 62977007968 Walker A motif; other site 62977007969 ATP binding site [chemical binding]; other site 62977007970 Walker B motif; other site 62977007971 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 62977007972 IHF dimer interface [polypeptide binding]; other site 62977007973 IHF - DNA interface [nucleotide binding]; other site 62977007974 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 62977007975 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 62977007976 putative tRNA-binding site [nucleotide binding]; other site 62977007977 B3/4 domain; Region: B3_4; pfam03483 62977007978 tRNA synthetase B5 domain; Region: B5; pfam03484 62977007979 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 62977007980 dimer interface [polypeptide binding]; other site 62977007981 motif 1; other site 62977007982 motif 3; other site 62977007983 motif 2; other site 62977007984 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 62977007985 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 62977007986 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 62977007987 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 62977007988 dimer interface [polypeptide binding]; other site 62977007989 motif 1; other site 62977007990 active site 62977007991 motif 2; other site 62977007992 motif 3; other site 62977007993 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 62977007994 23S rRNA binding site [nucleotide binding]; other site 62977007995 L21 binding site [polypeptide binding]; other site 62977007996 L13 binding site [polypeptide binding]; other site 62977007997 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 62977007998 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 62977007999 putative substrate translocation pore; other site 62977008000 H+ Antiporter protein; Region: 2A0121; TIGR00900 62977008001 Gram-negative bacterial tonB protein; Region: TonB; cl10048 62977008002 Predicted membrane protein [Function unknown]; Region: COG1238 62977008003 GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972 62977008004 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 62977008005 C-terminal domain interface [polypeptide binding]; other site 62977008006 GSH binding site (G-site) [chemical binding]; other site 62977008007 dimer interface [polypeptide binding]; other site 62977008008 C-terminal, alpha helical domain of Escherichia coli YfcG Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YfcG_like; cd10291 62977008009 N-terminal domain interface [polypeptide binding]; other site 62977008010 putative dimer interface [polypeptide binding]; other site 62977008011 active site 62977008012 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 62977008013 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 62977008014 putative dimer interface [polypeptide binding]; other site 62977008015 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 62977008016 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 62977008017 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 62977008018 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 62977008019 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 62977008020 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 62977008021 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 62977008022 active site 62977008023 dimer interface [polypeptide binding]; other site 62977008024 motif 1; other site 62977008025 motif 2; other site 62977008026 motif 3; other site 62977008027 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 62977008028 anticodon binding site; other site 62977008029 acyl-CoA synthetase; Validated; Region: PRK08162 62977008030 Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles and Arabidopsis; Region: ttLC_FACS_AEE21_like; cd12118 62977008031 acyl-activating enzyme (AAE) consensus motif; other site 62977008032 putative active site [active] 62977008033 AMP binding site [chemical binding]; other site 62977008034 putative CoA binding site [chemical binding]; other site 62977008035 hypothetical protein; Provisional; Region: PRK05255 62977008036 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 62977008037 dimerization domain swap beta strand [polypeptide binding]; other site 62977008038 regulatory protein interface [polypeptide binding]; other site 62977008039 active site 62977008040 regulatory phosphorylation site [posttranslational modification]; other site 62977008041 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 62977008042 AAA domain; Region: AAA_18; pfam13238 62977008043 pantoate--beta-alanine ligase; Region: panC; TIGR00018 62977008044 Pantoate-beta-alanine ligase; Region: PanC; cd00560 62977008045 active site 62977008046 ATP-binding site [chemical binding]; other site 62977008047 pantoate-binding site; other site 62977008048 HXXH motif; other site 62977008049 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 62977008050 active site 62977008051 oligomerization interface [polypeptide binding]; other site 62977008052 metal binding site [ion binding]; metal-binding site 62977008053 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 62977008054 catalytic center binding site [active] 62977008055 ATP binding site [chemical binding]; other site 62977008056 poly(A) polymerase; Region: pcnB; TIGR01942 62977008057 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 62977008058 active site 62977008059 NTP binding site [chemical binding]; other site 62977008060 metal binding triad [ion binding]; metal-binding site 62977008061 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 62977008062 Polymerase A arginine-rich C-terminus; Region: PolyA_pol_arg_C; pfam12626 62977008063 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 62977008064 Helix-hairpin-helix motif; Region: HHH; pfam00633 62977008065 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 62977008066 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 62977008067 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 62977008068 homodimer interface [polypeptide binding]; other site 62977008069 metal binding site [ion binding]; metal-binding site 62977008070 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 62977008071 homodimer interface [polypeptide binding]; other site 62977008072 active site 62977008073 putative chemical substrate binding site [chemical binding]; other site 62977008074 metal binding site [ion binding]; metal-binding site 62977008075 short chain dehydrogenase; Provisional; Region: PRK08267 62977008076 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 62977008077 NAD(P) binding site [chemical binding]; other site 62977008078 active site 62977008079 HD domain; Region: HD_4; pfam13328 62977008080 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 62977008081 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 62977008082 synthetase active site [active] 62977008083 NTP binding site [chemical binding]; other site 62977008084 metal binding site [ion binding]; metal-binding site 62977008085 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 62977008086 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 62977008087 23S rRNA m(5)U1939 methyltransferase; Reviewed; Region: rumA; PRK13168 62977008088 TRAM domain; Region: TRAM; pfam01938 62977008089 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 62977008090 S-adenosylmethionine binding site [chemical binding]; other site 62977008091 Uncharacterized bacterial subgroup of the DEDDy 3'-5' exonuclease domain of family-B DNA polymerases; Region: DNA_polB_like1_exo; cd05782 62977008092 active site 62977008093 catalytic site [active] 62977008094 substrate binding site [chemical binding]; other site 62977008095 Predicted 3'-5' exonuclease related to the exonuclease domain of PolB; Region: DNA_pol_B_exo2; pfam10108 62977008096 cysteine synthase B; Region: cysM; TIGR01138 62977008097 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 62977008098 dimer interface [polypeptide binding]; other site 62977008099 pyridoxal 5'-phosphate binding site [chemical binding]; other site 62977008100 catalytic residue [active] 62977008101 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 62977008102 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 62977008103 dimer interface [polypeptide binding]; other site 62977008104 phosphorylation site [posttranslational modification] 62977008105 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 62977008106 ATP binding site [chemical binding]; other site 62977008107 Mg2+ binding site [ion binding]; other site 62977008108 G-X-G motif; other site 62977008109 Response regulator receiver domain; Region: Response_reg; pfam00072 62977008110 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 62977008111 active site 62977008112 phosphorylation site [posttranslational modification] 62977008113 intermolecular recognition site; other site 62977008114 dimerization interface [polypeptide binding]; other site 62977008115 FOG: HPt domain [Signal transduction mechanisms]; Region: ArcB; COG2198 62977008116 putative binding surface; other site 62977008117 active site 62977008118 enoyl-CoA hydratase; Provisional; Region: PRK07509 62977008119 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 62977008120 substrate binding site [chemical binding]; other site 62977008121 oxyanion hole (OAH) forming residues; other site 62977008122 trimer interface [polypeptide binding]; other site 62977008123 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 62977008124 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 62977008125 hydroxypyruvate isomerase; Region: OH-pyruv-isom; TIGR03234 62977008126 iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090 62977008127 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 62977008128 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; COG1282 62977008129 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 62977008130 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 62977008131 NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288 62977008132 ligand binding site [chemical binding]; other site 62977008133 homodimer interface [polypeptide binding]; other site 62977008134 NAD(P) binding site [chemical binding]; other site 62977008135 trimer interface B [polypeptide binding]; other site 62977008136 trimer interface A [polypeptide binding]; other site 62977008137 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 62977008138 EamA-like transporter family; Region: EamA; pfam00892 62977008139 EamA-like transporter family; Region: EamA; pfam00892 62977008140 Helix-Turn-Helix DNA binding domain of the SoxR transcription regulator; Region: HTH_SoxR; cd01110 62977008141 redox-sensitive transcriptional activator SoxR; Region: SoxR; TIGR01950 62977008142 DNA binding residues [nucleotide binding] 62977008143 dimer interface [polypeptide binding]; other site 62977008144 [2Fe-2S] cluster binding site [ion binding]; other site 62977008145 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 62977008146 homotrimer interaction site [polypeptide binding]; other site 62977008147 putative active site [active] 62977008148 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 62977008149 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 62977008150 putative substrate translocation pore; other site 62977008151 tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815 62977008152 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 62977008153 FMN binding site [chemical binding]; other site 62977008154 active site 62977008155 catalytic residues [active] 62977008156 substrate binding site [chemical binding]; other site 62977008157 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179 62977008158 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 62977008159 putative ATP binding site [chemical binding]; other site 62977008160 putative substrate interface [chemical binding]; other site 62977008161 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 62977008162 homotrimer interaction site [polypeptide binding]; other site 62977008163 putative active site [active] 62977008164 aconitate hydratase; Validated; Region: PRK09277 62977008165 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 62977008166 substrate binding site [chemical binding]; other site 62977008167 ligand binding site [chemical binding]; other site 62977008168 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 62977008169 substrate binding site [chemical binding]; other site 62977008170 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 62977008171 active site 62977008172 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 62977008173 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 62977008174 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 62977008175 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 62977008176 G1 box; other site 62977008177 putative GEF interaction site [polypeptide binding]; other site 62977008178 GTP/Mg2+ binding site [chemical binding]; other site 62977008179 Switch I region; other site 62977008180 G2 box; other site 62977008181 G3 box; other site 62977008182 Switch II region; other site 62977008183 G4 box; other site 62977008184 G5 box; other site 62977008185 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 62977008186 MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300 62977008187 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 62977008188 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 62977008189 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 62977008190 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 62977008191 metal binding site [ion binding]; metal-binding site 62977008192 active site 62977008193 I-site; other site 62977008194 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 62977008195 ketol-acid reductoisomerase; Provisional; Region: PRK05479 62977008196 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 62977008197 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 62977008198 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 62977008199 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 62977008200 putative valine binding site [chemical binding]; other site 62977008201 dimer interface [polypeptide binding]; other site 62977008202 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 62977008203 acetolactate synthase 3 catalytic subunit; Validated; Region: PRK06466 62977008204 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 62977008205 PYR/PP interface [polypeptide binding]; other site 62977008206 dimer interface [polypeptide binding]; other site 62977008207 TPP binding site [chemical binding]; other site 62977008208 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 62977008209 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 62977008210 TPP-binding site [chemical binding]; other site 62977008211 dimer interface [polypeptide binding]; other site 62977008212 Domain of unknown function (DUF4124); Region: DUF4124; pfam13511 62977008213 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 62977008214 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 62977008215 HIGH motif; other site 62977008216 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 62977008217 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 62977008218 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 62977008219 active site 62977008220 KMSKS motif; other site 62977008221 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 62977008222 tRNA binding surface [nucleotide binding]; other site 62977008223 Lipopolysaccharide-assembly; Region: LptE; pfam04390 62977008224 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 62977008225 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 62977008226 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 62977008227 Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999 62977008228 HlyD family secretion protein; Region: HlyD_3; pfam13437 62977008229 macrolide transporter ATP-binding /permease protein; Provisional; Region: PRK10535 62977008230 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 62977008231 Walker A/P-loop; other site 62977008232 ATP binding site [chemical binding]; other site 62977008233 Q-loop/lid; other site 62977008234 ABC transporter signature motif; other site 62977008235 Walker B; other site 62977008236 D-loop; other site 62977008237 H-loop/switch region; other site 62977008238 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 62977008239 FtsX-like permease family; Region: FtsX; pfam02687 62977008240 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 62977008241 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 62977008242 Uncharacterized conserved protein [Function unknown]; Region: COG1262 62977008243 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 62977008244 Uncharacterized conserved protein [Function unknown]; Region: COG1262 62977008245 Uncharacterized protein conserved in bacteria [Function unknown]; Region: VgrG; COG3501 62977008246 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 62977008247 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 62977008248 Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296 62977008249 Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; pfam10106 62977008250 Enoyl-[acyl-carrier-protein]; Region: FabI; COG0623 62977008251 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 62977008252 NAD binding site [chemical binding]; other site 62977008253 homotetramer interface [polypeptide binding]; other site 62977008254 homodimer interface [polypeptide binding]; other site 62977008255 substrate binding site [chemical binding]; other site 62977008256 active site 62977008257 Bax inhibitor 1 like; Region: BaxI_1; cl17691 62977008258 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 62977008259 catalytic site [active] 62977008260 putative active site [active] 62977008261 putative substrate binding site [chemical binding]; other site 62977008262 dimer interface [polypeptide binding]; other site 62977008263 GTPase RsgA; Reviewed; Region: PRK00098 62977008264 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 62977008265 RNA binding site [nucleotide binding]; other site 62977008266 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 62977008267 GTPase/Zn-binding domain interface [polypeptide binding]; other site 62977008268 GTP/Mg2+ binding site [chemical binding]; other site 62977008269 G4 box; other site 62977008270 G5 box; other site 62977008271 G1 box; other site 62977008272 Switch I region; other site 62977008273 G2 box; other site 62977008274 G3 box; other site 62977008275 Switch II region; other site 62977008276 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 62977008277 active site residue [active] 62977008278 Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418 62977008279 GSH binding site [chemical binding]; other site 62977008280 catalytic residues [active] 62977008281 preprotein translocase subunit SecB; Validated; Region: PRK05751 62977008282 SecA binding site; other site 62977008283 Preprotein binding site; other site 62977008284 Cytochrome b562; Region: Cytochrom_B562; pfam07361 62977008285 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 62977008286 Flavoprotein; Region: Flavoprotein; pfam02441 62977008287 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 62977008288 hypothetical protein; Reviewed; Region: PRK00024 62977008289 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 62977008290 MPN+ (JAMM) motif; other site 62977008291 Zinc-binding site [ion binding]; other site 62977008292 Bestrophin, RFP-TM, chloride channel; Region: Bestrophin; pfam01062 62977008293 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 62977008294 active site 62977008295 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 62977008296 catalytic tetrad [active] 62977008297 Transcriptional regulator [Transcription]; Region: LysR; COG0583 62977008298 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 62977008299 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 62977008300 putative effector binding pocket; other site 62977008301 dimerization interface [polypeptide binding]; other site 62977008302 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 62977008303 GST_N family, unknown subfamily 2; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_2; cd03047 62977008304 putative C-terminal domain interface [polypeptide binding]; other site 62977008305 putative GSH binding site (G-site) [chemical binding]; other site 62977008306 putative dimer interface [polypeptide binding]; other site 62977008307 C-terminal, alpha helical domain of an unknown subfamily 2 of Glutathione S-transferases; Region: GST_C_2; cd03180 62977008308 putative N-terminal domain interface [polypeptide binding]; other site 62977008309 putative dimer interface [polypeptide binding]; other site 62977008310 putative substrate binding pocket (H-site) [chemical binding]; other site 62977008311 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 62977008312 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 62977008313 active site 62977008314 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 62977008315 Intracellular septation protein A; Region: IspA; pfam04279 62977008316 YciI-like protein; Reviewed; Region: PRK12863 62977008317 SH3 domain protein; Region: SH3_and_anchor; TIGR04211 62977008318 Uncharacterized conserved protein [Function unknown]; Region: COG4121 62977008319 bifunctional tRNA (mnm(5)s(2)U34)-methyltransferase/FAD-dependent cmnm(5)s(2)U34 oxidoreductase; Reviewed; Region: mnmC; PRK01747 62977008320 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 62977008321 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 62977008322 active site residue [active] 62977008323 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 62977008324 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 62977008325 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 62977008326 CoenzymeA binding site [chemical binding]; other site 62977008327 subunit interaction site [polypeptide binding]; other site 62977008328 PHB binding site; other site 62977008329 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 62977008330 thioredoxin 2; Provisional; Region: PRK10996 62977008331 zinc-ribbon domain; Region: zinc_ribbon_5; cl11777 62977008332 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 62977008333 catalytic residues [active] 62977008334 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 62977008335 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 62977008336 Putative phosphatase (DUF442); Region: DUF442; cl17385 62977008337 Putative phosphatase (DUF442); Region: DUF442; cl17385 62977008338 Bacterial Ig-like domain (group 1); Region: Big_1; cl17740 62977008339 dihydrolipoamide dehydrogenase; Validated; Region: PRK06292 62977008340 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 62977008341 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 62977008342 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 62977008343 Phosphorylase superfamily; Region: PNP_UDP_1; pfam01048 62977008344 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 62977008345 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 62977008346 Protein involved in catabolism of external DNA [General function prediction only]; Region: ComJ; COG2961 62977008347 Predicted proline hydroxylase [Posttranslational modification, protein turnover, chaperones]; Region: EGL-9; COG3751 62977008348 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; pfam13640 62977008349 Protein of unknown function (DUF2789); Region: DUF2789; pfam10982 62977008350 malate dehydrogenase; Provisional; Region: PRK05442 62977008351 Chloroplast-like malate dehydrogenases; Region: MDH_choloroplast_like; cd01338 62977008352 NAD(P) binding site [chemical binding]; other site 62977008353 dimer interface [polypeptide binding]; other site 62977008354 malate binding site [chemical binding]; other site 62977008355 Ribonuclease T2 (RNase T2) is a widespread family of secreted RNases found in every organism examined thus far. This family includes RNase Rh, RNase MC1, RNase LE, and self-incompatibility RNases (S-RNases). Plant T2 RNases are expressed during leaf...; Region: RNase_T2_prok; cd01062 62977008356 B1 nucleotide binding pocket [chemical binding]; other site 62977008357 B2 nucleotide binding pocket [chemical binding]; other site 62977008358 CAS motifs; other site 62977008359 active site 62977008360 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 62977008361 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 62977008362 N-acetyl-D-glucosamine binding site [chemical binding]; other site 62977008363 catalytic residue [active] 62977008364 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325 62977008365 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 62977008366 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 62977008367 FeS/SAM binding site; other site 62977008368 TRAM domain; Region: TRAM; cl01282 62977008369 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 62977008370 PhoH-like protein; Region: PhoH; pfam02562 62977008371 Uncharacterized protein family UPF0054; Region: UPF0054; pfam02130 62977008372 ferric-rhodotorulic acid outer membrane transporter; Provisional; Region: PRK10003 62977008373 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 62977008374 N-terminal plug; other site 62977008375 ligand-binding site [chemical binding]; other site 62977008376 Protein of unknown function (DUF3108); Region: DUF3108; pfam11306 62977008377 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 62977008378 active site 62977008379 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 62977008380 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 62977008381 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 62977008382 Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918 62977008383 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 62977008384 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 62977008385 The C-terminal substrate binding domain of LysR-type transcrptional regulator BudR, which is responsible for activation of the expression of the butanediol operon genes; contains the type 2 periplasmic binding fold; Region: PBP2_BudR; cd08451 62977008386 putative dimerization interface [polypeptide binding]; other site 62977008387 putative substrate binding pocket [chemical binding]; other site 62977008388 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 62977008389 putative substrate translocation pore; other site 62977008390 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 62977008391 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 62977008392 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 62977008393 YcxB-like protein; Region: YcxB; pfam14317 62977008394 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 62977008395 GAF domain; Region: GAF; pfam01590 62977008396 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 62977008397 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 62977008398 dimer interface [polypeptide binding]; other site 62977008399 phosphorylation site [posttranslational modification] 62977008400 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 62977008401 ATP binding site [chemical binding]; other site 62977008402 Mg2+ binding site [ion binding]; other site 62977008403 G-X-G motif; other site 62977008404 ribonuclease R; Region: RNase_R; TIGR02063 62977008405 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 62977008406 RNB domain; Region: RNB; pfam00773 62977008407 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 62977008408 RNA binding site [nucleotide binding]; other site 62977008409 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 62977008410 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 62977008411 active site 62977008412 Zn binding site [ion binding]; other site 62977008413 Probable metal-binding protein (DUF2387); Region: DUF2387; pfam09526 62977008414 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274 62977008415 rhomboid family GlyGly-CTERM serine protease; Region: rhom_GG_sort; TIGR03902 62977008416 Flavinator of succinate dehydrogenase; Region: Sdh5; cl01110 62977008417 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 62977008418 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 62977008419 active site 62977008420 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 62977008421 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 62977008422 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 62977008423 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 62977008424 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 62977008425 alphaNTD homodimer interface [polypeptide binding]; other site 62977008426 alphaNTD - beta interaction site [polypeptide binding]; other site 62977008427 alphaNTD - beta' interaction site [polypeptide binding]; other site 62977008428 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 62977008429 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 62977008430 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 62977008431 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 62977008432 RNA binding surface [nucleotide binding]; other site 62977008433 30S ribosomal protein S11; Validated; Region: PRK05309 62977008434 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 62977008435 30S ribosomal protein S13; Region: bact_S13; TIGR03631 62977008436 Ribosomal protein L36; Region: Ribosomal_L36; pfam00444 62977008437 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 62977008438 SecY translocase; Region: SecY; pfam00344 62977008439 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 62977008440 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 62977008441 23S rRNA binding site [nucleotide binding]; other site 62977008442 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 62977008443 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 62977008444 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 62977008445 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 62977008446 5S rRNA interface [nucleotide binding]; other site 62977008447 23S rRNA interface [nucleotide binding]; other site 62977008448 L5 interface [polypeptide binding]; other site 62977008449 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 62977008450 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 62977008451 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 62977008452 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 62977008453 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 62977008454 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 62977008455 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 62977008456 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 62977008457 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 62977008458 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 62977008459 RNA binding site [nucleotide binding]; other site 62977008460 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 62977008461 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 62977008462 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 62977008463 putative translocon interaction site; other site 62977008464 23S rRNA interface [nucleotide binding]; other site 62977008465 signal recognition particle (SRP54) interaction site; other site 62977008466 L23 interface [polypeptide binding]; other site 62977008467 trigger factor interaction site; other site 62977008468 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 62977008469 23S rRNA interface [nucleotide binding]; other site 62977008470 5S rRNA interface [nucleotide binding]; other site 62977008471 putative antibiotic binding site [chemical binding]; other site 62977008472 L25 interface [polypeptide binding]; other site 62977008473 L27 interface [polypeptide binding]; other site 62977008474 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 62977008475 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 62977008476 G-X-X-G motif; other site 62977008477 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 62977008478 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 62977008479 putative translocon binding site; other site 62977008480 protein-rRNA interface [nucleotide binding]; other site 62977008481 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 62977008482 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 62977008483 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 62977008484 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 62977008485 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 62977008486 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 62977008487 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 62977008488 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 62977008489 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 62977008490 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 62977008491 catalytic triad [active] 62977008492 cystathionine beta-lyase; Provisional; Region: PRK07050 62977008493 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 62977008494 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 62977008495 catalytic residue [active] 62977008496 Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872 62977008497 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 62977008498 Walker A motif; other site 62977008499 ATP binding site [chemical binding]; other site 62977008500 Transcriptional regulator [Transcription]; Region: LysR; COG0583 62977008501 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 62977008502 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 62977008503 dimerization interface [polypeptide binding]; other site 62977008504 substrate binding pocket [chemical binding]; other site 62977008505 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 62977008506 heme-binding site [chemical binding]; other site 62977008507 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 62977008508 FAD binding pocket [chemical binding]; other site 62977008509 conserved FAD binding motif [chemical binding]; other site 62977008510 phosphate binding motif [ion binding]; other site 62977008511 Transcriptional regulator; Region: Rrf2; cl17282 62977008512 Rrf2 family protein; Region: rrf2_super; TIGR00738 62977008513 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 62977008514 G1 box; other site 62977008515 GTP/Mg2+ binding site [chemical binding]; other site 62977008516 Switch I region; other site 62977008517 G2 box; other site 62977008518 G3 box; other site 62977008519 Switch II region; other site 62977008520 G4 box; other site 62977008521 G5 box; other site 62977008522 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687 62977008523 Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118 62977008524 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 62977008525 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 62977008526 Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946 62977008527 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 62977008528 active site 62977008529 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 62977008530 catalytic triad [active] 62977008531 dimer interface [polypeptide binding]; other site 62977008532 glycerol-3-phosphate O-acyltransferase; Region: plsB; TIGR03703 62977008533 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Region: LPLAT_DHAPAT-like; cd07993 62977008534 putative acyl-acceptor binding pocket; other site 62977008535 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 62977008536 membrane-bound complex binding site; other site 62977008537 atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266 62977008538 NADH(P)-binding; Region: NAD_binding_10; pfam13460 62977008539 putative NAD(P) binding site [chemical binding]; other site 62977008540 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 62977008541 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 62977008542 ssDNA binding site; other site 62977008543 generic binding surface II; other site 62977008544 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 62977008545 ATP binding site [chemical binding]; other site 62977008546 putative Mg++ binding site [ion binding]; other site 62977008547 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 62977008548 nucleotide binding region [chemical binding]; other site 62977008549 ATP-binding site [chemical binding]; other site 62977008550 comF family protein; Region: comF; TIGR00201 62977008551 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 62977008552 active site 62977008553 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_31; cd04690 62977008554 nudix motif; other site 62977008555 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 62977008556 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 62977008557 Escherichia coli Mg2+ transporter CorA_like subgroup; Region: EcCorA-like_1; cd12835 62977008558 Cl binding site [ion binding]; other site 62977008559 oligomer interface [polypeptide binding]; other site 62977008560 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 62977008561 anti sigma factor interaction site; other site 62977008562 regulatory phosphorylation site [posttranslational modification]; other site 62977008563 Toluene tolerance, Ttg2; Region: Tol_Tol_Ttg2; pfam05494 62977008564 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 62977008565 mce related protein; Region: MCE; pfam02470 62977008566 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 62977008567 Permease; Region: Permease; cl00510 62977008568 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 62977008569 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 62977008570 Walker A/P-loop; other site 62977008571 ATP binding site [chemical binding]; other site 62977008572 Q-loop/lid; other site 62977008573 ABC transporter signature motif; other site 62977008574 Walker B; other site 62977008575 D-loop; other site 62977008576 H-loop/switch region; other site 62977008577 ATP-dependent RNA helicase RhlB; Provisional; Region: PRK04837 62977008578 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 62977008579 ATP binding site [chemical binding]; other site 62977008580 Mg++ binding site [ion binding]; other site 62977008581 motif III; other site 62977008582 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 62977008583 nucleotide binding region [chemical binding]; other site 62977008584 ATP-binding site [chemical binding]; other site 62977008585 Invertebrate innate immunity transcript family; Region: Innate_immun; pfam12782 62977008586 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 62977008587 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 62977008588 active site 62977008589 dimerization interface [polypeptide binding]; other site 62977008590 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 62977008591 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 62977008592 TPP-binding site; other site 62977008593 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 62977008594 PYR/PP interface [polypeptide binding]; other site 62977008595 dimer interface [polypeptide binding]; other site 62977008596 TPP binding site [chemical binding]; other site 62977008597 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 62977008598 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 62977008599 dimerization interface [polypeptide binding]; other site 62977008600 active site 62977008601 coproporphyrinogen III oxidase; Provisional; Region: PRK05330 62977008602 Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; pfam01218 62977008603 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 62977008604 ferrochelatase; Reviewed; Region: hemH; PRK00035 62977008605 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 62977008606 C-terminal domain interface [polypeptide binding]; other site 62977008607 active site 62977008608 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 62977008609 active site 62977008610 N-terminal domain interface [polypeptide binding]; other site 62977008611 Domain of unknown function (DUF4062); Region: DUF4062; pfam13271 62977008612 glutamate racemase; Provisional; Region: PRK00865 62977008613 Protein of unknown function (DUF1285); Region: DUF1285; pfam06938 62977008614 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 62977008615 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 62977008616 Electron transfer flavoprotein-ubiquinone oxidoreductase; Region: ETF_QO; pfam05187 62977008617 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 62977008618 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 62977008619 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 62977008620 active site 62977008621 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 62977008622 putative glutamate synthase (NADPH) small subunit; Provisional; Region: PRK12771 62977008623 PspC domain; Region: PspC; pfam04024 62977008624 CBS-domain-containing membrane protein [Signal transduction mechanisms]; Region: COG3448 62977008625 HPP family; Region: HPP; pfam04982 62977008626 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 62977008627 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 62977008628 Poly(3-hydroxybutyrate) depolymerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LpqC; COG3509 62977008629 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 62977008630 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 62977008631 dimer interface [polypeptide binding]; other site 62977008632 motif 1; other site 62977008633 active site 62977008634 motif 2; other site 62977008635 motif 3; other site 62977008636 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 62977008637 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 62977008638 YCII-related domain; Region: YCII; cl00999 62977008639 YCII-related domain; Region: YCII; cl00999 62977008640 EamA-like transporter family; Region: EamA; pfam00892 62977008641 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 62977008642 EamA-like transporter family; Region: EamA; pfam00892 62977008643 Transcriptional regulator [Transcription]; Region: LysR; COG0583 62977008644 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 62977008645 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 62977008646 dimerization interface [polypeptide binding]; other site 62977008647 glycerate dehydrogenase; Provisional; Region: PRK06487 62977008648 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_4; cd12162 62977008649 putative ligand binding site [chemical binding]; other site 62977008650 putative NAD binding site [chemical binding]; other site 62977008651 catalytic site [active] 62977008652 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 62977008653 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 62977008654 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 62977008655 active site 62977008656 catalytic tetrad [active] 62977008657 Methyltransferase domain; Region: Methyltransf_31; pfam13847 62977008658 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 62977008659 S-adenosylmethionine binding site [chemical binding]; other site 62977008660 Endonuclease related to archaeal Holliday junction resolvase; Region: Endonuc_Holl; pfam10107 62977008661 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 62977008662 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 62977008663 P-loop; other site 62977008664 Magnesium ion binding site [ion binding]; other site 62977008665 Domain of unknown function DUF20; Region: UPF0118; pfam01594 62977008666 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 62977008667 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 62977008668 NADH(P)-binding; Region: NAD_binding_10; pfam13460 62977008669 NAD binding site [chemical binding]; other site 62977008670 substrate binding site [chemical binding]; other site 62977008671 putative active site [active] 62977008672 integral membrane protein, YccS/YhfK family; Region: YCCS_YHJK; TIGR01667 62977008673 FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805 62977008674 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 62977008675 multidrug efflux system translocase MdfA; Provisional; Region: PRK15402 62977008676 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 62977008677 putative substrate translocation pore; other site 62977008678 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 62977008679 Uncharacterized conserved protein [Function unknown]; Region: COG1359 62977008680 Cytidine and deoxycytidylate deaminase zinc-binding region. The family contains cytidine deaminases, nucleoside deaminases, deoxycytidylate deaminases and riboflavin deaminases. Also included are the apoBec family of mRNA editing enzymes. All members...; Region: cytidine_deaminase-like; cl00269 62977008681 Cytidine and deoxycytidylate deaminase zinc-binding region. The family contains cytidine deaminases, nucleoside deaminases, deoxycytidylate deaminases and riboflavin deaminases. Also included are the apoBec family of mRNA editing enzymes. All members...; Region: cytidine_deaminase-like; cl00269 62977008682 active site 62977008683 Zn binding site [ion binding]; other site 62977008684 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 62977008685 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 62977008686 NAD(P) binding site [chemical binding]; other site 62977008687 active site 62977008688 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 62977008689 FAD binding domain; Region: FAD_binding_4; pfam01565 62977008690 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790 62977008691 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_3; cd12176 62977008692 ligand binding site [chemical binding]; other site 62977008693 NAD binding site [chemical binding]; other site 62977008694 tetramer interface [polypeptide binding]; other site 62977008695 catalytic site [active] 62977008696 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 62977008697 L-serine binding site [chemical binding]; other site 62977008698 ACT domain interface; other site 62977008699 threonine and homoserine efflux system; Provisional; Region: PRK10532 62977008700 EamA-like transporter family; Region: EamA; pfam00892 62977008701 Threonine/homoserine efflux transporter [Amino acid transport and metabolism]; Region: rhtA; COG5006 62977008702 Hemerythrin-like domain; Region: Hr-like; cd12108 62977008703 hypothetical protein; Provisional; Region: PRK10621 62977008704 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 62977008705 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05033 62977008706 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 62977008707 RNA binding site [nucleotide binding]; other site 62977008708 active site 62977008709 Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157 62977008710 lipase chaperone; Provisional; Region: PRK01294 62977008711 Proteobacterial lipase chaperone protein; Region: Lipase_chap; pfam03280 62977008712 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 62977008713 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 62977008714 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 62977008715 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 62977008716 RimM N-terminal domain; Region: RimM; pfam01782 62977008717 PRC-barrel domain; Region: PRC; pfam05239 62977008718 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 62977008719 Tfp pilus assembly protein PilE [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilE; COG4968 62977008720 Tfp pilus assembly protein PilE [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilE; COG4968 62977008721 Neisseria PilC beta-propeller domain; Region: Neisseria_PilC; pfam05567 62977008722 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 62977008723 type IV pilus modification protein PilV; Region: type_IV_pilV; TIGR02523 62977008724 Type II transport protein GspH; Region: GspH; pfam12019 62977008725 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 62977008726 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 62977008727 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 62977008728 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 62977008729 catalytic site [active] 62977008730 G-X2-G-X-G-K; other site 62977008731 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 62977008732 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 62977008733 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 62977008734 Zn2+ binding site [ion binding]; other site 62977008735 Mg2+ binding site [ion binding]; other site 62977008736 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 62977008737 synthetase active site [active] 62977008738 NTP binding site [chemical binding]; other site 62977008739 metal binding site [ion binding]; metal-binding site 62977008740 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 62977008741 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 62977008742 homotrimer interaction site [polypeptide binding]; other site 62977008743 putative active site [active] 62977008744 Bacterioferritin-associated ferredoxin [Inorganic ion transport and metabolism]; Region: Bfd; COG2906 62977008745 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 62977008746 heme binding site [chemical binding]; other site 62977008747 Ferritin-like domain; Region: Ferritin; pfam00210 62977008748 ferroxidase pore; other site 62977008749 ferroxidase diiron center [ion binding]; other site 62977008750 Spore Coat Protein U domain; Region: SCPU; pfam05229 62977008751 Spore Coat Protein U domain; Region: SCPU; pfam05229 62977008752 Spore Coat Protein U domain; Region: SCPU; pfam05229 62977008753 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 62977008754 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 62977008755 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 62977008756 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 62977008757 Spore Coat Protein U domain; Region: SCPU; pfam05229 62977008758 O-Antigen ligase; Region: Wzy_C; pfam04932 62977008759 Pilin (bacterial filament); Region: Pilin; pfam00114 62977008760 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 62977008761 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297 62977008762 NAD binding site [chemical binding]; other site 62977008763 substrate binding site [chemical binding]; other site 62977008764 catalytic Zn binding site [ion binding]; other site 62977008765 tetramer interface [polypeptide binding]; other site 62977008766 structural Zn binding site [ion binding]; other site 62977008767 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cd07197 62977008768 Predicted amidohydrolase [General function prediction only]; Region: COG0388 62977008769 active site 62977008770 catalytic triad [active] 62977008771 dimer interface [polypeptide binding]; other site 62977008772 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 62977008773 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 62977008774 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 62977008775 catalytic residue [active] 62977008776 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 62977008777 biotin carboxylase-like protein; Validated; Region: PRK06524 62977008778 ATP-grasp domain; Region: ATP-grasp_4; cl17255 62977008779 Choloylglycine hydrolase (CGH)_like. This family of choloylglycine hydrolase-like proteins includes conjugated bile acid hydrolase (CBAH), penicillin V acylase (PVA), acid ceramidase (AC), and N-acylethanolamine-hydrolyzing acid amidase (NAAA) which...; Region: Ntn_CGH_like; cd01935 62977008780 active site 62977008781 Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase; Region: AAT; pfam03417 62977008782 Repair protein; Region: Repair_PSII; cl01535 62977008783 Beta-propeller domains of methanol dehydrogenase type [General function prediction only]; Region: COG1512 62977008784 Repair protein; Region: Repair_PSII; pfam04536 62977008785 LemA family; Region: LemA; pfam04011 62977008786 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687 62977008787 Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118 62977008788 glutamate synthase small subunit family protein, proteobacterial; Region: gltD_gamma_fam; TIGR01318 62977008789 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 62977008790 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 62977008791 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 62977008792 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 62977008793 active site 62977008794 dimer interface [polypeptide binding]; other site 62977008795 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 62977008796 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 62977008797 active site 62977008798 FMN binding site [chemical binding]; other site 62977008799 substrate binding site [chemical binding]; other site 62977008800 3Fe-4S cluster binding site [ion binding]; other site 62977008801 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 62977008802 domain interface; other site 62977008803 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 62977008804 active site 62977008805 dimer interface [polypeptide binding]; other site 62977008806 metal binding site [ion binding]; metal-binding site 62977008807 shikimate kinase; Reviewed; Region: aroK; PRK00131 62977008808 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 62977008809 ADP binding site [chemical binding]; other site 62977008810 magnesium binding site [ion binding]; other site 62977008811 putative shikimate binding site; other site 62977008812 AMIN domain; Region: AMIN; pfam11741 62977008813 type IV pilus secretin (or competence protein) PilQ; Region: IV_pilus_PilQ; TIGR02515 62977008814 Secretin and TonB N terminus short domain; Region: STN; smart00965 62977008815 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 62977008816 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 62977008817 Tfp pilus assembly protein PilP [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilP; COG3168 62977008818 Pilus assembly protein, PilP; Region: PilP; pfam04351 62977008819 Pilus assembly protein, PilO; Region: PilO; pfam04350 62977008820 Tfp pilus assembly protein PilN [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilN; COG3166 62977008821 Fimbrial assembly protein (PilN); Region: PilN; pfam05137 62977008822 Competence protein A; Region: Competence_A; pfam11104 62977008823 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 62977008824 penicillin-binding protein 1a; Provisional; Region: mrcA; PRK11636 62977008825 Transglycosylase; Region: Transgly; pfam00912 62977008826 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 62977008827 23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088 62977008828 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 62977008829 S-adenosylmethionine binding site [chemical binding]; other site 62977008830 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 62977008831 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 62977008832 Mg++ binding site [ion binding]; other site 62977008833 putative catalytic motif [active] 62977008834 putative substrate binding site [chemical binding]; other site 62977008835 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 62977008836 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Region: murF; TIGR01143 62977008837 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 62977008838 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 62977008839 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 62977008840 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 62977008841 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 62977008842 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 62977008843 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 62977008844 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 62977008845 Cell division protein FtsL; Region: FtsL; pfam04999 62977008846 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 62977008847 MraW methylase family; Region: Methyltransf_5; pfam01795 62977008848 ABC-type sulfate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: Sbp; COG1613 62977008849 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 62977008850 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 62977008851 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 62977008852 active site 62977008853 HIGH motif; other site 62977008854 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 62977008855 active site 62977008856 KMSKS motif; other site 62977008857 Domain of unknown function (DUF4379); Region: DUF4379; pfam14311 62977008858 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 62977008859 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 62977008860 heavy metal efflux pump, CzcA family; Region: 2A0601; TIGR00914 62977008861 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 62977008862 Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999 62977008863 HlyD family secretion protein; Region: HlyD_3; pfam13437 62977008864 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 62977008865 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 62977008866 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 62977008867 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 62977008868 ABC transporter; Region: ABC_tran_2; pfam12848 62977008869 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 62977008870 pyruvate dehydrogenase; Provisional; Region: PRK09124 62977008871 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 62977008872 PYR/PP interface [polypeptide binding]; other site 62977008873 dimer interface [polypeptide binding]; other site 62977008874 tetramer interface [polypeptide binding]; other site 62977008875 TPP binding site [chemical binding]; other site 62977008876 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 62977008877 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 62977008878 TPP-binding site [chemical binding]; other site 62977008879 O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK06084 62977008880 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 62977008881 homodimer interface [polypeptide binding]; other site 62977008882 substrate-cofactor binding pocket; other site 62977008883 pyridoxal 5'-phosphate binding site [chemical binding]; other site 62977008884 catalytic residue [active] 62977008885 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 62977008886 classical (c) SDRs; Region: SDR_c; cd05233 62977008887 NAD(P) binding site [chemical binding]; other site 62977008888 active site 62977008889 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 62977008890 Sulfate transporter family; Region: Sulfate_transp; pfam00916 62977008891 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378 62977008892 active site clefts [active] 62977008893 zinc binding site [ion binding]; other site 62977008894 dimer interface [polypeptide binding]; other site 62977008895 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 62977008896 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 62977008897 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 62977008898 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 62977008899 RNA binding site [nucleotide binding]; other site 62977008900 osmolarity response regulator; Provisional; Region: ompR; PRK09468 62977008901 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 62977008902 active site 62977008903 phosphorylation site [posttranslational modification] 62977008904 intermolecular recognition site; other site 62977008905 dimerization interface [polypeptide binding]; other site 62977008906 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 62977008907 DNA binding site [nucleotide binding] 62977008908 osmolarity sensor protein; Provisional; Region: envZ; PRK09467 62977008909 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 62977008910 dimer interface [polypeptide binding]; other site 62977008911 phosphorylation site [posttranslational modification] 62977008912 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 62977008913 ATP binding site [chemical binding]; other site 62977008914 Mg2+ binding site [ion binding]; other site 62977008915 G-X-G motif; other site 62977008916 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 62977008917 succinate CoA transferase; Region: YgfH_subfam; TIGR03458 62977008918 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 62977008919 putative acetyltransferase; Provisional; Region: PRK03624 62977008920 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 62977008921 Coenzyme A binding pocket [chemical binding]; other site 62977008922 Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; cl17479 62977008923 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 62977008924 S-adenosylmethionine binding site [chemical binding]; other site 62977008925 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 62977008926 Coenzyme A binding pocket [chemical binding]; other site 62977008927 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 62977008928 putative active site pocket [active] 62977008929 4-fold oligomerization interface [polypeptide binding]; other site 62977008930 metal binding residues [ion binding]; metal-binding site 62977008931 3-fold/trimer interface [polypeptide binding]; other site 62977008932 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141 62977008933 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 62977008934 putative active site [active] 62977008935 oxyanion strand; other site 62977008936 catalytic triad [active] 62977008937 Protein of unknown function (DUF805); Region: DUF805; pfam05656 62977008938 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 62977008939 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 62977008940 catalytic residues [active] 62977008941 The adenylation (A) domain of siderophore-synthesizing nonribosomal peptide synthetases (NRPS); Region: A_NRPS_SidN3_like; cd05918 62977008942 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 62977008943 acyl-activating enzyme (AAE) consensus motif; other site 62977008944 AMP binding site [chemical binding]; other site 62977008945 non-ribosomal peptide synthetase terminal domain of unknown function; Region: NRPS_term_dom; TIGR02353 62977008946 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 62977008947 putative trimer interface [polypeptide binding]; other site 62977008948 putative CoA binding site [chemical binding]; other site 62977008949 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 62977008950 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 62977008951 putative CoA binding site [chemical binding]; other site 62977008952 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 62977008953 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 62977008954 Walker A/P-loop; other site 62977008955 ATP binding site [chemical binding]; other site 62977008956 Q-loop/lid; other site 62977008957 ABC transporter signature motif; other site 62977008958 Walker B; other site 62977008959 D-loop; other site 62977008960 H-loop/switch region; other site 62977008961 Predicted membrane protein [Function unknown]; Region: COG3671 62977008962 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 62977008963 DNA-binding site [nucleotide binding]; DNA binding site 62977008964 RNA-binding motif; other site 62977008965 Protein of unknown function (DUF1294); Region: DUF1294; pfam06961 62977008966 Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334 62977008967 Homoserine Kinase, type II. Homoserine kinase is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and...; Region: HomoserineK_II; cd05153 62977008968 putative active site [active] 62977008969 putative substrate binding site [chemical binding]; other site 62977008970 ATP binding site [chemical binding]; other site 62977008971 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 62977008972 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 62977008973 substrate binding site [chemical binding]; other site 62977008974 glutamase interaction surface [polypeptide binding]; other site 62977008975 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 62977008976 Helix-turn-helix domain; Region: HTH_18; pfam12833 62977008977 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 62977008978 DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases. They exists as monomers and homodimers; Region: NUC; cd00091 62977008979 DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892 62977008980 active site 62977008981 substrate binding site [chemical binding]; other site 62977008982 Mg2+ binding site [ion binding]; other site 62977008983 K+ transporter [Inorganic ion transport and metabolism]; Region: Kup; COG3158 62977008984 potassium uptake protein; Region: kup; TIGR00794 62977008985 Domain of unknown function (DUF4102); Region: DUF4102; pfam13356 62977008986 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 62977008987 Fic/DOC family N-terminal; Region: Fic_N; pfam13784 62977008988 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 62977008989 multidrug efflux system subunit MdtC; Provisional; Region: PRK10614 62977008990 Domain of unknown function (DUF4396); Region: DUF4396; pfam14342 62977008991 multidrug efflux system subunit MdtB; Provisional; Region: PRK10503 62977008992 Protein export membrane protein; Region: SecD_SecF; cl14618 62977008993 multidrug efflux system subunit MdtA; Provisional; Region: PRK11556 62977008994 HlyD family secretion protein; Region: HlyD_3; pfam13437 62977008995 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 62977008996 Uncharacterized protein conserved in bacteria [Function unknown]; Region: VgrG; COG3501 62977008997 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 62977008998 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 62977008999 Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296 62977009000 Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; pfam10106 62977009001 Domain of unknown function (DUF4411); Region: DUF4411; pfam14367 62977009002 Domain of unknown function (DUF955); Region: DUF955; cl01076 62977009003 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 62977009004 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 62977009005 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 62977009006 ATP binding site [chemical binding]; other site 62977009007 putative Mg++ binding site [ion binding]; other site 62977009008 EcoKI restriction-modification system protein HsdS; Provisional; Region: PRK09737 62977009009 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 62977009010 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 62977009011 HsdM N-terminal domain; Region: HsdM_N; pfam12161 62977009012 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 62977009013 Methyltransferase domain; Region: Methyltransf_26; pfam13659 62977009014 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 62977009015 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 62977009016 Uncharacterized conserved protein [Function unknown]; Region: COG1479 62977009017 Protein of unknown function DUF262; Region: DUF262; pfam03235 62977009018 GIY-YIG domain of uncharacterized hypothetical protein found in bacteria and archaea; Region: GIY-YIG_unchar_2; cd10447 62977009019 GIY-YIG motif/motif A; other site 62977009020 putative active site [active] 62977009021 putative metal binding site [ion binding]; other site 62977009022 Domain of unknown function (DUF4357); Region: DUF4357; pfam14267 62977009023 Protein of unknown function (DUF805); Region: DUF805; pfam05656 62977009024 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 62977009025 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 62977009026 Kef-type K+ transport systems, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: Kch; COG1226 62977009027 TrkA-N domain; Region: TrkA_N; pfam02254 62977009028 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 62977009029 S-adenosylmethionine binding site [chemical binding]; other site 62977009030 Predicted NAD/FAD-binding protein [General function prediction only]; Region: COG2907 62977009031 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 62977009032 Pirin-related protein [General function prediction only]; Region: COG1741 62977009033 Pirin; Region: Pirin; pfam02678 62977009034 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 62977009035 succinic semialdehyde dehydrogenase; Region: PLN02278 62977009036 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 62977009037 tetramerization interface [polypeptide binding]; other site 62977009038 NAD(P) binding site [chemical binding]; other site 62977009039 catalytic residues [active] 62977009040 4-aminobutyrate aminotransferase; Provisional; Region: PRK06777 62977009041 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 62977009042 inhibitor-cofactor binding pocket; inhibition site 62977009043 pyridoxal 5'-phosphate binding site [chemical binding]; other site 62977009044 catalytic residue [active] 62977009045 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 62977009046 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 62977009047 DNA-binding site [nucleotide binding]; DNA binding site 62977009048 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 62977009049 pyridoxal 5'-phosphate binding site [chemical binding]; other site 62977009050 homodimer interface [polypeptide binding]; other site 62977009051 catalytic residue [active] 62977009052 gamma-aminobutyrate permease; Region: GABAperm; TIGR01773 62977009053 Spore germination protein; Region: Spore_permease; cl17796 62977009054 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 62977009055 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 62977009056 dimer interface [polypeptide binding]; other site 62977009057 ssDNA binding site [nucleotide binding]; other site 62977009058 tetramer (dimer of dimers) interface [polypeptide binding]; other site 62977009059 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 62977009060 Major Facilitator Superfamily; Region: MFS_1; pfam07690 62977009061 hypothetical protein; Provisional; Region: PRK14013 62977009062 Putative transcription activator [Transcription]; Region: TenA; COG0819 62977009063 GlpM protein; Region: GlpM; pfam06942 62977009064 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 62977009065 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 62977009066 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 62977009067 Q-loop/lid; other site 62977009068 ABC transporter signature motif; other site 62977009069 Walker B; other site 62977009070 D-loop; other site 62977009071 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 62977009072 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 62977009073 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 62977009074 metal binding site [ion binding]; metal-binding site 62977009075 active site 62977009076 I-site; other site 62977009077 BCCT family transporter; Region: BCCT; pfam02028 62977009078 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 62977009079 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 62977009080 Na binding site [ion binding]; other site 62977009081 Protein of unknown function, DUF485; Region: DUF485; pfam04341 62977009082 Na+/proline symporter [Amino acid transport and metabolism / General function prediction only]; Region: PutP; COG0591 62977009083 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 62977009084 Na binding site [ion binding]; other site 62977009085 PAS fold; Region: PAS_7; pfam12860 62977009086 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 62977009087 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 62977009088 dimer interface [polypeptide binding]; other site 62977009089 phosphorylation site [posttranslational modification] 62977009090 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 62977009091 ATP binding site [chemical binding]; other site 62977009092 Mg2+ binding site [ion binding]; other site 62977009093 G-X-G motif; other site 62977009094 Response regulator receiver domain; Region: Response_reg; pfam00072 62977009095 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 62977009096 active site 62977009097 phosphorylation site [posttranslational modification] 62977009098 intermolecular recognition site; other site 62977009099 dimerization interface [polypeptide binding]; other site 62977009100 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cl16941 62977009101 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 62977009102 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 62977009103 active site 62977009104 phosphorylation site [posttranslational modification] 62977009105 intermolecular recognition site; other site 62977009106 dimerization interface [polypeptide binding]; other site 62977009107 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 62977009108 DNA binding residues [nucleotide binding] 62977009109 dimerization interface [polypeptide binding]; other site 62977009110 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 62977009111 FMN reductase, MsuE subfamily; Region: FMN_reduc_MsuE; TIGR03566 62977009112 dimethyl sulfone monooxygenase SfnG; Region: LLM_DMSO2_sfnG; TIGR04021 62977009113 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 62977009114 active site 62977009115 dimer interface [polypeptide binding]; other site 62977009116 non-prolyl cis peptide bond; other site 62977009117 insertion regions; other site 62977009118 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 62977009119 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 62977009120 Isochorismatase family; Region: Isochorismatase; pfam00857 62977009121 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 62977009122 catalytic triad [active] 62977009123 conserved cis-peptide bond; other site 62977009124 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 62977009125 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 62977009126 active site 62977009127 acetyl-CoA synthetase; Provisional; Region: PRK00174 62977009128 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 62977009129 active site 62977009130 CoA binding site [chemical binding]; other site 62977009131 acyl-activating enzyme (AAE) consensus motif; other site 62977009132 AMP binding site [chemical binding]; other site 62977009133 acetate binding site [chemical binding]; other site 62977009134 Protein of unknown function (DUF805); Region: DUF805; pfam05656 62977009135 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 62977009136 Mechanosensitive ion channel; Region: MS_channel; pfam00924 62977009137 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 62977009138 3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749 62977009139 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 62977009140 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 62977009141 flavin-dependent oxidoreductase, MSMEG_0569 family; Region: MSMEG_0569_nitr; TIGR04046 62977009142 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 62977009143 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312 62977009144 Phosphate-selective porin O and P; Region: Porin_O_P; pfam07396 62977009145 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 62977009146 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 62977009147 substrate binding pocket [chemical binding]; other site 62977009148 membrane-bound complex binding site; other site 62977009149 hinge residues; other site 62977009150 hypothetical protein; Provisional; Region: PRK07490 62977009151 intersubunit interface [polypeptide binding]; other site 62977009152 active site 62977009153 Zn2+ binding site [ion binding]; other site 62977009154 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; pfam05721 62977009155 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 62977009156 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 62977009157 substrate binding pocket [chemical binding]; other site 62977009158 membrane-bound complex binding site; other site 62977009159 hinge residues; other site 62977009160 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 62977009161 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 62977009162 dimer interface [polypeptide binding]; other site 62977009163 conserved gate region; other site 62977009164 putative PBP binding loops; other site 62977009165 ABC-ATPase subunit interface; other site 62977009166 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 62977009167 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 62977009168 Walker A/P-loop; other site 62977009169 ATP binding site [chemical binding]; other site 62977009170 Q-loop/lid; other site 62977009171 ABC transporter signature motif; other site 62977009172 Walker B; other site 62977009173 D-loop; other site 62977009174 H-loop/switch region; other site 62977009175 acetylornithine deacetylase; Provisional; Region: PRK07522 62977009176 M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894 62977009177 metal binding site [ion binding]; metal-binding site 62977009178 putative dimer interface [polypeptide binding]; other site 62977009179 Transcriptional regulator [Transcription]; Region: LysR; COG0583 62977009180 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 62977009181 The C-terminal substrate-binding domain of putative LysR-type transcriptional regulator PAO1-like, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_PAO1_like; cd08412 62977009182 putative substrate binding pocket [chemical binding]; other site 62977009183 dimerization interface [polypeptide binding]; other site 62977009184 Family of unknown function (DUF1028); Region: DUF1028; pfam06267 62977009185 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 62977009186 homotrimer interaction site [polypeptide binding]; other site 62977009187 putative active site [active] 62977009188 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 62977009189 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 62977009190 FMN binding site [chemical binding]; other site 62977009191 active site 62977009192 substrate binding site [chemical binding]; other site 62977009193 catalytic residue [active] 62977009194 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 62977009195 dimerization interface [polypeptide binding]; other site 62977009196 putative DNA binding site [nucleotide binding]; other site 62977009197 putative Zn2+ binding site [ion binding]; other site 62977009198 peptide chain release factor 2; Provisional; Region: PRK08787 62977009199 This domain is found in peptide chain release factors; Region: PCRF; smart00937 62977009200 RF-1 domain; Region: RF-1; pfam00472 62977009201 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 62977009202 ssDNA exonuclease RecJ; Provisional; Region: PRK11070 62977009203 DHH family; Region: DHH; pfam01368 62977009204 DHHA1 domain; Region: DHHA1; pfam02272 62977009205 pyridoxamine-phosphate oxidase; Region: pdxH; TIGR00558 62977009206 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 62977009207 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 62977009208 phosphoglucosamine mutase; Provisional; Region: glmM; PRK10887 62977009209 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 62977009210 active site 62977009211 substrate binding site [chemical binding]; other site 62977009212 metal binding site [ion binding]; metal-binding site 62977009213 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 62977009214 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 62977009215 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 62977009216 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 62977009217 active site 62977009218 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 62977009219 Predicted membrane protein [Function unknown]; Region: COG2119 62977009220 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 62977009221 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 62977009222 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 62977009223 pyruvate dehydrogenase dihydrolipoyltransacetylase; Validated; Region: aceF; PRK11854 62977009224 E3 interaction surface; other site 62977009225 lipoyl attachment site [posttranslational modification]; other site 62977009226 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 62977009227 E3 interaction surface; other site 62977009228 lipoyl attachment site [posttranslational modification]; other site 62977009229 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 62977009230 E3 interaction surface; other site 62977009231 lipoyl attachment site [posttranslational modification]; other site 62977009232 e3 binding domain; Region: E3_binding; pfam02817 62977009233 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 62977009234 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 62977009235 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 62977009236 dimer interface [polypeptide binding]; other site 62977009237 TPP-binding site [chemical binding]; other site 62977009238 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 62977009239 Peptidase family M23; Region: Peptidase_M23; pfam01551 62977009240 Protein of unknown function (DUF721); Region: DUF721; cl02324 62977009241 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186 62977009242 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 62977009243 cell division protein FtsZ; Validated; Region: PRK09330 62977009244 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 62977009245 nucleotide binding site [chemical binding]; other site 62977009246 SulA interaction site; other site 62977009247 Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849 62977009248 Cell division protein FtsA; Region: FtsA; smart00842 62977009249 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 62977009250 Cell division protein FtsA; Region: FtsA; pfam14450 62977009251 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 62977009252 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 62977009253 Cell division protein FtsQ; Region: FtsQ; pfam03799 62977009254 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 62977009255 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 62977009256 ATP-grasp domain; Region: ATP-grasp_4; cl17255 62977009257 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 62977009258 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 62977009259 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 62977009260 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 62977009261 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 62977009262 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 62977009263 active site 62977009264 homodimer interface [polypeptide binding]; other site 62977009265 glutathione synthetase; Provisional; Region: PRK05246 62977009266 Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951 62977009267 Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955 62977009268 Domain of unknown function (DUF4394); Region: DUF4394; pfam14339 62977009269 Domain of unknown function (DUF4394); Region: DUF4394; pfam14339 62977009270 Domain of unknown function (DUF1737); Region: DUF1737; pfam08410 62977009271 Flavin Reductases; Region: FlaRed; cl00801 62977009272 methionine synthase; Provisional; Region: PRK01207 62977009273 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 62977009274 substrate binding site [chemical binding]; other site 62977009275 THF binding site; other site 62977009276 zinc-binding site [ion binding]; other site 62977009277 Domain of unknown function (DUF1852); Region: DUF1852; pfam08908 62977009278 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 62977009279 active site 62977009280 Neisseria meningitides Nape-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Nape_like_AP-endo; cd10281 62977009281 putative active site [active] 62977009282 putative catalytic site [active] 62977009283 putative DNA binding site [nucleotide binding]; other site 62977009284 putative phosphate binding site [ion binding]; other site 62977009285 metal binding site A [ion binding]; metal-binding site 62977009286 putative AP binding site [nucleotide binding]; other site 62977009287 putative metal binding site B [ion binding]; other site 62977009288 Arsenate Reductase (ArsC) family, Yffb subfamily; Yffb is an uncharacterized bacterial protein encoded by the yffb gene, related to the thioredoxin-fold arsenic reductases, ArsC. The structure of Yffb and the conservation of the catalytic cysteine...; Region: ArsC_Yffb; cd03035 62977009289 ArsC family; Region: ArsC; pfam03960 62977009290 putative catalytic residues [active] 62977009291 Uncharacterized protein conserved in bacteria (DUF2147); Region: DUF2147; pfam09917 62977009292 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 62977009293 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 62977009294 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 62977009295 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 62977009296 metal binding site [ion binding]; metal-binding site 62977009297 active site 62977009298 I-site; other site 62977009299 thiol:disulfide interchange protein precursor; Provisional; Region: dipZ; PRK00293 62977009300 Disulphide bond corrector protein DsbC; Region: DsbC; pfam11412 62977009301 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 62977009302 DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953 62977009303 DsbD alpha interface [polypeptide binding]; other site 62977009304 catalytic residues [active] 62977009305 Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; pfam13557 62977009306 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 62977009307 Ankyrin repeats (many copies); Region: Ank_5; pfam13857 62977009308 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cl00250 62977009309 30S subunit binding site; other site 62977009310 putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212 62977009311 Catalytic domain of bacterial PuuE allantoinases, Schizosaccharomyces pombe chitin deacetylase 1 (SpCDA1), and similar proteins; Region: CE4_PuuE_SpCDA1; cd10977 62977009312 active site 62977009313 catalytic site [active] 62977009314 tetramer interface [polypeptide binding]; other site 62977009315 OHCU decarboxylase; Region: UraD_2; TIGR03180 62977009316 HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822 62977009317 active site 62977009318 homotetramer interface [polypeptide binding]; other site 62977009319 Nucleoside-specific channel-forming protein, Tsx; Region: Channel_Tsx; cl04114 62977009320 hypothetical protein; Provisional; Region: PRK07236 62977009321 FAD binding domain; Region: FAD_binding_3; pfam01494 62977009322 allantoicase; Region: allantoicase; TIGR02961 62977009323 Allantoicase repeat; Region: Allantoicase; pfam03561 62977009324 Allantoicase repeat; Region: Allantoicase; pfam03561 62977009325 ureidoglycolate hydrolase; Provisional; Region: PRK03606 62977009326 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 62977009327 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 62977009328 ATP binding site [chemical binding]; other site 62977009329 Mg2+ binding site [ion binding]; other site 62977009330 G-X-G motif; other site 62977009331 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 62977009332 anchoring element; other site 62977009333 dimer interface [polypeptide binding]; other site 62977009334 ATP binding site [chemical binding]; other site 62977009335 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 62977009336 active site 62977009337 metal binding site [ion binding]; metal-binding site 62977009338 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 62977009339 Uncharacterized protein family (UPF0227); Region: UPF0227; cl14886 62977009340 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 62977009341 PGAP1-like protein; Region: PGAP1; pfam07819 62977009342 Disulfide bond formation protein DsbB; Region: DsbB; pfam02600 62977009343 Glutamate-cysteine ligase; Region: Glu_cys_ligase; cl17352 62977009344 Bacterial protein of unknown function (DUF924); Region: DUF924; pfam06041 62977009345 Protein of unknown function (DUF445); Region: DUF445; pfam04286 62977009346 methionine aminotransferase; Validated; Region: PRK09082 62977009347 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 62977009348 pyridoxal 5'-phosphate binding site [chemical binding]; other site 62977009349 homodimer interface [polypeptide binding]; other site 62977009350 catalytic residue [active] 62977009351 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 62977009352 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138 62977009353 hypothetical protein; Provisional; Region: PRK06194 62977009354 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 62977009355 NAD(P) binding site [chemical binding]; other site 62977009356 active site 62977009357 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 62977009358 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 62977009359 phosphate regulon transcriptional regulatory protein PhoB; Region: PhoB; TIGR02154 62977009360 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 62977009361 active site 62977009362 phosphorylation site [posttranslational modification] 62977009363 intermolecular recognition site; other site 62977009364 dimerization interface [polypeptide binding]; other site 62977009365 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 62977009366 DNA binding site [nucleotide binding] 62977009367 Domain of unknown function (DUF3329); Region: DUF3329; pfam11808 62977009368 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 62977009369 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 62977009370 dimer interface [polypeptide binding]; other site 62977009371 phosphorylation site [posttranslational modification] 62977009372 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 62977009373 ATP binding site [chemical binding]; other site 62977009374 Mg2+ binding site [ion binding]; other site 62977009375 G-X-G motif; other site 62977009376 PEGA domain; Region: PEGA; pfam08308 62977009377 phosphatidylserine decarboxylase; Reviewed; Region: psd; PRK00044 62977009378 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 62977009379 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 62977009380 active site residue [active] 62977009381 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 62977009382 active site residue [active] 62977009383 nicotinate phosphoribosyltransferase; Region: NAPRTase; TIGR01514 62977009384 Nicotinate phosphoribosyltransferase (NAPRTase), related to PncB. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting; Region: PncB_like; cd01401 62977009385 active site 62977009386 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 62977009387 putative active site [active] 62977009388 dimerization interface [polypeptide binding]; other site 62977009389 putative tRNAtyr binding site [nucleotide binding]; other site 62977009390 CT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_1; cd04870 62977009391 ACT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_2; cd04871 62977009392 phosphoserine phosphatase SerB; Region: serB; TIGR00338 62977009393 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 62977009394 motif II; other site 62977009395 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II-like protein; Provisional; Region: PRK14019 62977009396 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 62977009397 GTP cyclohydrolase II; Region: GTP_cyclohydro2; pfam00925 62977009398 dimerization interface [polypeptide binding]; other site 62977009399 active site 62977009400 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 62977009401 homopentamer interface [polypeptide binding]; other site 62977009402 active site 62977009403 transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202 62977009404 thiamine monophosphate kinase; Provisional; Region: PRK05731 62977009405 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 62977009406 ATP binding site [chemical binding]; other site 62977009407 dimerization interface [polypeptide binding]; other site 62977009408 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 62977009409 tetramer interfaces [polypeptide binding]; other site 62977009410 binuclear metal-binding site [ion binding]; other site 62977009411 N-acetylglucosamine-1-phosphate uridyltransferase (contains nucleotidyltransferase and I-patch acetyltransferase domains) [Cell envelope biogenesis, outer membrane]; Region: GlmU; COG1207 62977009412 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 62977009413 Substrate binding site; other site 62977009414 Mg++ binding site; other site 62977009415 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 62977009416 active site 62977009417 substrate binding site [chemical binding]; other site 62977009418 CoA binding site [chemical binding]; other site 62977009419 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 62977009420 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 62977009421 glutaminase active site [active] 62977009422 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 62977009423 dimer interface [polypeptide binding]; other site 62977009424 active site 62977009425 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 62977009426 dimer interface [polypeptide binding]; other site 62977009427 active site 62977009428 Domain of unknown function (DUF1969); Region: DUF1969; pfam09298 62977009429 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 62977009430 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 62977009431 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 62977009432 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 62977009433 Coenzyme A binding pocket [chemical binding]; other site 62977009434 Uncharacterized conserved protein [Function unknown]; Region: COG1683 62977009435 bile acid transporter; Region: bass; TIGR00841 62977009436 Sodium Bile acid symporter family; Region: SBF; pfam01758 62977009437 Isochorismatase family; Region: Isochorismatase; pfam00857 62977009438 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 62977009439 catalytic triad [active] 62977009440 metal binding site [ion binding]; metal-binding site 62977009441 conserved cis-peptide bond; other site 62977009442 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 62977009443 dihydrodipicolinate synthase; Region: dapA; TIGR00674 62977009444 dimer interface [polypeptide binding]; other site 62977009445 active site 62977009446 catalytic residue [active] 62977009447 Uncharacterized lipoprotein [Cell envelope biogenesis, outer membrane]; Region: NlpB; COG3317 62977009448 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 62977009449 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 62977009450 ATP binding site [chemical binding]; other site 62977009451 active site 62977009452 substrate binding site [chemical binding]; other site 62977009453 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 62977009454 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 62977009455 substrate binding pocket [chemical binding]; other site 62977009456 membrane-bound complex binding site; other site 62977009457 hinge residues; other site 62977009458 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 62977009459 dimer interface [polypeptide binding]; other site 62977009460 conserved gate region; other site 62977009461 ABC-ATPase subunit interface; other site 62977009462 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 62977009463 dimer interface [polypeptide binding]; other site 62977009464 conserved gate region; other site 62977009465 putative PBP binding loops; other site 62977009466 ABC-ATPase subunit interface; other site 62977009467 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 62977009468 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 62977009469 Walker A/P-loop; other site 62977009470 ATP binding site [chemical binding]; other site 62977009471 Q-loop/lid; other site 62977009472 ABC transporter signature motif; other site 62977009473 Walker B; other site 62977009474 D-loop; other site 62977009475 H-loop/switch region; other site 62977009476 Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226 62977009477 PAS fold; Region: PAS_4; pfam08448 62977009478 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 62977009479 PAS domain; Region: PAS_9; pfam13426 62977009480 putative active site [active] 62977009481 heme pocket [chemical binding]; other site 62977009482 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 62977009483 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 62977009484 metal binding site [ion binding]; metal-binding site 62977009485 active site 62977009486 I-site; other site 62977009487 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 62977009488 recombination factor protein RarA; Reviewed; Region: PRK13342 62977009489 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 62977009490 Walker A motif; other site 62977009491 ATP binding site [chemical binding]; other site 62977009492 Walker B motif; other site 62977009493 arginine finger; other site 62977009494 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 62977009495 beta-lactamase/D-alanine carboxypeptidase; Provisional; Region: ampC; PRK11289 62977009496 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 62977009497 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 62977009498 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 62977009499 Helix-Turn-Helix DNA binding domain of the CadR and PbrR transcription regulators; Region: HTH_CadR-PbrR; cd04784 62977009500 DNA binding residues [nucleotide binding] 62977009501 Cd(II)/Pb(II)-responsive transcriptional regulator; Region: CadR-PbrR; TIGR02047 62977009502 dimer interface [polypeptide binding]; other site 62977009503 putative metal binding site [ion binding]; other site 62977009504 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 62977009505 hypothetical protein; Provisional; Region: PRK05170 62977009506 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 62977009507 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 62977009508 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 62977009509 nucleotide binding site/active site [active] 62977009510 HIT family signature motif; other site 62977009511 catalytic residue [active] 62977009512 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 62977009513 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 62977009514 minor groove reading motif; other site 62977009515 helix-hairpin-helix signature motif; other site 62977009516 substrate binding pocket [chemical binding]; other site 62977009517 active site 62977009518 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 62977009519 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 62977009520 DNA binding and oxoG recognition site [nucleotide binding] 62977009521 Peptidase family M23; Region: Peptidase_M23; pfam01551 62977009522 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 62977009523 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 62977009524 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 62977009525 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 62977009526 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 62977009527 putative NAD(P) binding site [chemical binding]; other site 62977009528 putative substrate binding site [chemical binding]; other site 62977009529 catalytic Zn binding site [ion binding]; other site 62977009530 structural Zn binding site [ion binding]; other site 62977009531 dimer interface [polypeptide binding]; other site 62977009532 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 62977009533 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 62977009534 DNA-binding site [nucleotide binding]; DNA binding site 62977009535 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 62977009536 pyridoxal 5'-phosphate binding site [chemical binding]; other site 62977009537 homodimer interface [polypeptide binding]; other site 62977009538 catalytic residue [active] 62977009539 Transcriptional regulator [Transcription]; Region: LysR; COG0583 62977009540 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 62977009541 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 62977009542 dimerization interface [polypeptide binding]; other site 62977009543 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 62977009544 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 62977009545 active site 62977009546 catalytic tetrad [active] 62977009547 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 62977009548 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 62977009549 putative substrate translocation pore; other site 62977009550 Uncharacterized subgroup of the steroidogenic acute regulatory protein (StAR)-related lipid transfer (START) domain family; Region: START_1; cd08876 62977009551 putative lipid binding site [chemical binding]; other site 62977009552 dihydrodipicolinate reductase; Provisional; Region: PRK00048 62977009553 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 62977009554 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 62977009555 chaperone protein DnaJ; Provisional; Region: PRK10767 62977009556 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 62977009557 HSP70 interaction site [polypeptide binding]; other site 62977009558 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 62977009559 substrate binding site [polypeptide binding]; other site 62977009560 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 62977009561 Zn binding sites [ion binding]; other site 62977009562 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 62977009563 dimer interface [polypeptide binding]; other site 62977009564 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 62977009565 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 62977009566 HlyD family secretion protein; Region: HlyD_3; pfam13437 62977009567 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 62977009568 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 62977009569 phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009 62977009570 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 62977009571 pyrimidine utilization transport protein G; Region: RutG; TIGR03616 62977009572 Transcriptional regulator [Transcription]; Region: LysR; COG0583 62977009573 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 62977009574 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 62977009575 dimerization interface [polypeptide binding]; other site 62977009576 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 62977009577 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 62977009578 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 62977009579 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 62977009580 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 62977009581 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 62977009582 putative active site [active] 62977009583 substrate binding site [chemical binding]; other site 62977009584 putative cosubstrate binding site; other site 62977009585 catalytic site [active] 62977009586 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 62977009587 substrate binding site [chemical binding]; other site 62977009588 16S rRNA methyltransferase B; Provisional; Region: PRK10901 62977009589 NusB family; Region: NusB; pfam01029 62977009590 putative RNA binding site [nucleotide binding]; other site 62977009591 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 62977009592 S-adenosylmethionine binding site [chemical binding]; other site 62977009593 zinc transporter ZupT; Provisional; Region: PRK04201 62977009594 uncharacterized bacterial and archaeal solute carrier 6 subfamily; solute-binding domain; Region: SLC6sbd_u1; cd10334 62977009595 Na2 binding site [ion binding]; other site 62977009596 putative substrate binding site 1 [chemical binding]; other site 62977009597 Na binding site 1 [ion binding]; other site 62977009598 putative substrate binding site 2 [chemical binding]; other site 62977009599 Aldehyde dehydrogenase family 21A1-like; Region: ALDH_F21_RNP123; cd07147 62977009600 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 62977009601 NAD(P) binding site [chemical binding]; other site 62977009602 catalytic residues [active] 62977009603 outer membrane protein; Region: OMP_w_GlyGly; TIGR04219 62977009604 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4307 62977009605 Uncharacterized protein conserved in bacteria (DUF2248); Region: DUF2248; pfam10005 62977009606 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 62977009607 intracellular protease, PfpI family; Region: PfpI; TIGR01382 62977009608 proposed catalytic triad [active] 62977009609 conserved cys residue [active] 62977009610 peptidyl-prolyl cis-trans isomerase A (rotamase A); Provisional; Region: PRK10903 62977009611 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 62977009612 substrate binding site [chemical binding]; other site 62977009613 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 62977009614 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 62977009615 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 62977009616 Transcriptional regulator [Transcription]; Region: LysR; COG0583 62977009617 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 62977009618 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 62977009619 putative effector binding pocket; other site 62977009620 dimerization interface [polypeptide binding]; other site 62977009621 GrpE; Region: GrpE; pfam01025 62977009622 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 62977009623 dimer interface [polypeptide binding]; other site 62977009624 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 62977009625 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 62977009626 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 62977009627 nucleotide binding site [chemical binding]; other site 62977009628 Transglycosylase SLT domain; Region: SLT_2; pfam13406 62977009629 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 62977009630 N-acetyl-D-glucosamine binding site [chemical binding]; other site 62977009631 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 62977009632 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 62977009633 ATP-grasp domain; Region: ATP-grasp; pfam02222 62977009634 AIR carboxylase; Region: AIRC; pfam00731 62977009635 Protein of unknown function, DUF486; Region: DUF486; cl01236 62977009636 UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase; Region: mpl; TIGR01081 62977009637 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 62977009638 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 62977009639 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 62977009640 PAP2_like proteins, BcrC_like subfamily. Several members of this family have been annotated as bacitracin transport permeases, as it was suspected that they form the permease component of an ABC transporter system. It was shown, however, that BcrC from...; Region: PAP2_BcrC_like; cd03385 62977009641 active site 62977009642 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 62977009643 Bacterial protein of unknown function (DUF925); Region: DUF925; pfam06042 62977009644 guanine deaminase; Provisional; Region: PRK09228 62977009645 Guanine deaminase (GDEase). Guanine deaminase is an aminohydrolase responsible for the conversion of guanine to xanthine and ammonia, the first step to utilize guanine as a nitrogen source. This reaction also removes the guanine base from the pool and...; Region: GDEase; cd01303 62977009646 active site 62977009647 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 62977009648 active site 62977009649 Predicted membrane protein [Function unknown]; Region: COG2261 62977009650 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 62977009651 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020 62977009652 dimerization domain [polypeptide binding]; other site 62977009653 dimer interface [polypeptide binding]; other site 62977009654 catalytic residues [active] 62977009655 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 62977009656 GH3 auxin-responsive promoter; Region: GH3; pfam03321 62977009657 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 62977009658 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 62977009659 putative substrate translocation pore; other site 62977009660 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 62977009661 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 62977009662 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 62977009663 HlyD family secretion protein; Region: HlyD_3; pfam13437 62977009664 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 62977009665 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 62977009666 trmE is a tRNA modification GTPase; Region: trmE; cd04164 62977009667 G1 box; other site 62977009668 GTP/Mg2+ binding site [chemical binding]; other site 62977009669 Switch I region; other site 62977009670 G2 box; other site 62977009671 Switch II region; other site 62977009672 G3 box; other site 62977009673 G4 box; other site 62977009674 G5 box; other site 62977009675 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 62977009676 membrane protein insertase; Provisional; Region: PRK01318 62977009677 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 62977009678 hypothetical protein; Provisional; Region: PRK14386 62977009679 Ribonuclease P; Region: Ribonuclease_P; cl00457 62977009680 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399