-- dump date 20111121_010127 -- class Genbank::misc_feature -- table misc_feature_note -- id note 436717000001 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 436717000002 Myosin and Kinesin motor domain. These ATPases belong to the P-loop NTPase family and provide the driving force in myosin and kinesin mediated processes; Region: Motor_domain; cl00286 436717000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 436717000004 Walker A motif; other site 436717000005 ATP binding site [chemical binding]; other site 436717000006 ATP-binding site [chemical binding]; other site 436717000007 Walker B motif; other site 436717000008 arginine finger; other site 436717000009 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 436717000010 DnaA box-binding interface [nucleotide binding]; other site 436717000011 DNA polymerase III subunit beta; Validated; Region: PRK05643 436717000012 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the...; Region: beta_clamp; cd00140 436717000013 putative DNA binding surface [nucleotide binding]; other site 436717000014 dimer interface [polypeptide binding]; other site 436717000015 beta-clamp/clamp loader binding surface; other site 436717000016 beta-clamp/translesion DNA polymerase binding surface; other site 436717000017 recombination protein F; Reviewed; Region: recF; PRK00064 436717000018 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 436717000019 Walker A/P-loop; other site 436717000020 ATP binding site [chemical binding]; other site 436717000021 Q-loop/lid; other site 436717000022 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 436717000023 ABC transporter signature motif; other site 436717000024 Walker B; other site 436717000025 D-loop; other site 436717000026 H-loop/switch region; other site 436717000027 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 436717000028 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 436717000029 Mg2+ binding site [ion binding]; other site 436717000030 G-X-G motif; other site 436717000031 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are...; Region: TopoII_Trans_DNA_gyrase; cd00822 436717000032 anchoring element; other site 436717000033 dimer interface [polypeptide binding]; other site 436717000034 ATP binding site [chemical binding]; other site 436717000035 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of...; Region: TOPRIM_TopoIIA_GyrB; cd03366 436717000036 active site 436717000037 putative metal-binding site [ion binding]; other site 436717000038 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 436717000039 Cytochrome b562; Region: Cytochrom_B562; cl01546 436717000040 Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823 436717000041 putative ABC transporter ATP-binding protein; Provisional; Region: PRK10636 436717000042 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by...; Region: ABCF_EF-3; cd03221 436717000043 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 436717000044 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by...; Region: ABCF_EF-3; cd03221 436717000045 ABC transporter; Region: ABC_tran_2; pfam12848 436717000046 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by...; Region: ABCF_EF-3; cd03221 436717000047 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 436717000048 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl00710 436717000049 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 436717000050 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 436717000051 Uncharacterised protein family (UPF0075); Region: UPF0075; cl04217 436717000052 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 436717000053 active site 436717000054 HIGH motif; other site 436717000055 dimer interface [polypeptide binding]; other site 436717000056 KMSKS motif; other site 436717000057 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 436717000058 GST_N family, unknown subfamily 4; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_4; cd03056 436717000059 putative C-terminal domain interface [polypeptide binding]; other site 436717000060 putative GSH binding site (G-site) [chemical binding]; other site 436717000061 putative dimer interface [polypeptide binding]; other site 436717000062 GST_C family, unknown subfamily 1; composed of uncharacterized bacterial proteins, with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_C_1; cd03179 436717000063 putative N-terminal domain interface [polypeptide binding]; other site 436717000064 putative dimer interface [polypeptide binding]; other site 436717000065 putative substrate binding pocket (H-site) [chemical binding]; other site 436717000066 Sodium:neurotransmitter symporter family; Region: SNF; cl11976 436717000067 16S rRNA methyltransferase B; Provisional; Region: PRK10901 436717000068 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the rRNA-...; Region: NusB_Sun; cl00223 436717000069 putative RNA binding site [nucleotide binding]; other site 436717000070 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 436717000071 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 436717000072 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 436717000073 putative active site [active] 436717000074 substrate binding site [chemical binding]; other site 436717000075 putative cosubstrate binding site; other site 436717000076 catalytic site [active] 436717000077 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 436717000078 substrate binding site [chemical binding]; other site 436717000079 Dehydratase family; Region: ILVD_EDD; cl00340 436717000080 dihydroxy-acid dehydratase; Region: ilvD; TIGR00110 436717000081 Predicted permeases [General function prediction only]; Region: COG0730; cl00498 436717000082 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 436717000083 Transcriptional regulator [Transcription]; Region: LysR; COG0583 436717000084 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 436717000085 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 436717000086 dimerization interface [polypeptide binding]; other site 436717000087 Sulfate transporter family; Region: Sulfate_transp; cl00967 436717000088 Permease family; Region: Xan_ur_permease; pfam00860 436717000089 Phosphoenolpyruvate carboxylase [Carbohydrate transport and metabolism; Energy production and conversion]; Region: COG1892; cl14656 436717000090 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 436717000091 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 436717000092 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 436717000093 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 436717000094 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 436717000095 Inorganic H+ pyrophosphatase; Region: H_PPase; pfam03030 436717000096 chaperone protein DnaJ; Provisional; Region: PRK10767 436717000097 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of...; Region: DnaJ; cd06257 436717000098 HSP70 interaction site [polypeptide binding]; other site 436717000099 DnaJ central domain; Region: DnaJ_CXXCXGXG; cl14908 436717000100 DnaJ C terminal domain; Region: DnaJ_C; pfam01556 436717000101 DnaJ C terminal domain; Region: DnaJ_C; pfam01556 436717000102 dihydrodipicolinate reductase; Provisional; Region: PRK00048 436717000103 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 436717000104 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 436717000105 Uncharacterized subgroup of the steroidogenic acute regulatory protein (StAR)-related lipid transfer (START) domain family; Region: START_1; cd08876 436717000106 putative lipid binding site [chemical binding]; other site 436717000107 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 436717000108 putative substrate translocation pore; other site 436717000109 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and...; Region: Aldo_ket_red; cd06660 436717000110 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 436717000111 active site 436717000112 catalytic tetrad [active] 436717000113 Transcriptional regulator [Transcription]; Region: LysR; COG0583 436717000114 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 436717000115 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA; cd08478 436717000116 putative effector binding pocket; other site 436717000117 dimerization interface [polypeptide binding]; other site 436717000118 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 436717000119 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 436717000120 DNA-binding site [nucleotide binding]; DNA binding site 436717000121 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 436717000122 pyridoxal 5'-phosphate binding site [chemical binding]; other site 436717000123 homodimer interface [polypeptide binding]; other site 436717000124 catalytic residue [active] 436717000125 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 436717000126 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 436717000127 putative NAD(P) binding site [chemical binding]; other site 436717000128 putative substrate binding site [chemical binding]; other site 436717000129 catalytic Zn binding site [ion binding]; other site 436717000130 structural Zn binding site [ion binding]; other site 436717000131 dimer interface [polypeptide binding]; other site 436717000132 Methyladenine glycosylase; Region: Adenine_glyco; cl01059 436717000133 Peptidase family M23; Region: Peptidase_M23; pfam01551 436717000134 A/G-specific adenine glycosylase; Region: mutY; TIGR01084 436717000135 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 436717000136 minor groove reading motif; other site 436717000137 helix-hairpin-helix signature motif; other site 436717000138 substrate binding pocket [chemical binding]; other site 436717000139 active site 436717000140 FES domain; Region: FES; smart00525 436717000141 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 436717000142 DNA binding and oxoG recognition site [nucleotide binding] 436717000143 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the...; Region: HIT_like; cl00228 436717000144 nucleotide binding site/active site [active] 436717000145 HIT family signature motif; other site 436717000146 catalytic residue [active] 436717000147 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 436717000148 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 436717000149 Flagellin N-methylase; Region: FliB; cl00497 436717000150 Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133 436717000151 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 436717000152 recombination factor protein RarA; Reviewed; Region: PRK13342 436717000153 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 436717000154 Walker A motif; other site 436717000155 ATP binding site [chemical binding]; other site 436717000156 Walker B motif; other site 436717000157 arginine finger; other site 436717000158 MgsA AAA+ ATPase C terminal; Region: MgsA_C; cl13440 436717000159 Formate/nitrite transporter; Region: Form_Nir_trans; cl00927 436717000160 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 436717000161 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 436717000162 ATP binding site [chemical binding]; other site 436717000163 active site 436717000164 substrate binding site [chemical binding]; other site 436717000165 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 436717000166 dihydrodipicolinate synthase; Region: dapA; TIGR00674 436717000167 dimer interface [polypeptide binding]; other site 436717000168 active site 436717000169 catalytic residue [active] 436717000170 Isochorismatase family; Region: Isochorismatase; pfam00857 436717000171 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 436717000172 catalytic triad [active] 436717000173 metal binding site [ion binding]; metal-binding site 436717000174 conserved cis-peptide bond; other site 436717000175 Membrane transport protein; Region: Mem_trans; cl09117 436717000176 putative efflux protein, MATE family; Region: matE; TIGR00797 436717000177 MatE; Region: MatE; pfam01554 436717000178 MatE; Region: MatE; pfam01554 436717000179 Protein of unknown function (DUF523); Region: DUF523; cl00733 436717000180 4-hydroxyphenylpyruvate dioxygenase; Region: 4HPPD; TIGR01263 436717000181 N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342 436717000182 dimer interface [polypeptide binding]; other site 436717000183 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250 436717000184 active site 436717000185 Fe binding site [ion binding]; other site 436717000186 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 436717000187 Bacterial transcriptional regulator; Region: IclR; pfam01614 436717000188 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 436717000189 Zn binding site [ion binding]; other site 436717000190 GST_N family, Class Zeta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens...; Region: GST_N_Zeta; cd03042 436717000191 maleylacetoacetate isomerase; Region: maiA; TIGR01262 436717000192 C-terminal domain interface [polypeptide binding]; other site 436717000193 GSH binding site (G-site) [chemical binding]; other site 436717000194 putative dimer interface [polypeptide binding]; other site 436717000195 GST_C family, Class Zeta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens...; Region: GST_C_Zeta; cd03191 436717000196 dimer interface [polypeptide binding]; other site 436717000197 N-terminal domain interface [polypeptide binding]; other site 436717000198 putative maleylacetoacetate (MAA) substrate binding site (H site); other site 436717000199 fumarylacetoacetase; Region: PLN02856 436717000200 Domain of unknown function (DUF1969); Region: DUF1969; pfam09298 436717000201 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 436717000202 Transmembrane amino acid transporter protein; Region: Aa_trans; cl00524 436717000203 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 436717000204 Peptidase M15; Region: Peptidase_M15_3; cl01194 436717000205 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 436717000206 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 436717000207 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; cl08458 436717000208 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 436717000209 histidine utilization repressor, proteobacterial; Region: his_ut_repres; TIGR02018 436717000210 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 436717000211 DNA-binding site [nucleotide binding]; DNA binding site 436717000212 UTRA domain; Region: UTRA; cl06649 436717000213 HutD; Region: HutD; cl01532 436717000214 urocanate hydratase; Provisional; Region: PRK05414 436717000215 urocanate hydratase; Region: hutU; TIGR01228 436717000216 tyrosine 2,3-aminomutase; Region: Tyr_2_3_mutase; TIGR03832 436717000217 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 436717000218 active sites [active] 436717000219 tetramer interface [polypeptide binding]; other site 436717000220 Transmembrane amino acid transporter protein; Region: Aa_trans; cl00524 436717000221 Amino acid permease; Region: AA_permease; pfam00324 436717000222 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 436717000223 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria...; Region: Imidazolone-5PH; cd01296 436717000224 active site 436717000225 Arginase family; Region: Arginase; cl00306 436717000226 Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960 436717000227 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 436717000228 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 436717000229 motif II; other site 436717000230 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 436717000231 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 436717000232 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate...; Region: GFAT; cd00714 436717000233 glutaminase active site [active] 436717000234 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 436717000235 dimer interface [polypeptide binding]; other site 436717000236 active site 436717000237 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 436717000238 dimer interface [polypeptide binding]; other site 436717000239 active site 436717000240 UDP-N-acetylglucosamine diphosphorylase/glucosamine-1-phosphate N-acetyltransferase; Region: glmU; TIGR01173 436717000241 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 436717000242 Substrate binding site [chemical binding]; other site 436717000243 Mg++ binding site [ion binding]; other site 436717000244 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 436717000245 active site 436717000246 substrate binding site [chemical binding]; other site 436717000247 CoA binding site [chemical binding]; other site 436717000248 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 436717000249 tetramer interfaces [polypeptide binding]; other site 436717000250 binuclear metal-binding site [ion binding]; other site 436717000251 thiamine monophosphate kinase; Provisional; Region: PRK05731 436717000252 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 436717000253 ATP binding site [chemical binding]; other site 436717000254 dimerization interface [polypeptide binding]; other site 436717000255 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the rRNA-...; Region: NusB_Sun; cl00223 436717000256 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 436717000257 homopentamer interface [polypeptide binding]; other site 436717000258 active site 436717000259 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II-like protein; Provisional; Region: PRK14019 436717000260 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; cl00336 436717000261 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cl00522 436717000262 dimerization interface [polypeptide binding]; other site 436717000263 active site 436717000264 CT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_1; cd04870 436717000265 ACT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_2; cd04871 436717000266 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 436717000267 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 436717000268 motif II; other site 436717000269 putative fimbrial protein StkD; Provisional; Region: PRK15306; cl14700 436717000270 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but...; Region: Dtyr_deacylase; cd00563 436717000271 putative active site [active] 436717000272 dimerization interface [polypeptide binding]; other site 436717000273 putative tRNAtyr binding site [nucleotide binding]; other site 436717000274 nicotinate phosphoribosyltransferase; Region: NAPRTase; TIGR01514 436717000275 Nicotinate phosphoribosyltransferase (NAPRTase), related to PncB. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting...; Region: PncB_like; cd01401 436717000276 active site 436717000277 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 436717000278 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but...; Region: TST_Repeat_1; cd01448 436717000279 active site residue [active] 436717000280 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 436717000281 active site residue [active] 436717000282 Phosphatidylserine decarboxylase; Region: PS_Dcarbxylase; cl03656 436717000283 Acetamidase/Formamidase family; Region: FmdA_AmdA; cl01023 436717000284 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 436717000285 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 436717000286 Secretory lipase; Region: LIP; pfam03583 436717000287 Domain of unknown function (DUF3329); Region: DUF3329; pfam11808 436717000288 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 436717000289 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 436717000290 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 436717000291 dimer interface [polypeptide binding]; other site 436717000292 phosphorylation site [posttranslational modification] 436717000293 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 436717000294 ATP binding site [chemical binding]; other site 436717000295 Mg2+ binding site [ion binding]; other site 436717000296 G-X-G motif; other site 436717000297 phosphate regulon transcriptional regulatory protein PhoB; Region: PhoB; TIGR02154 436717000298 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 436717000299 active site 436717000300 phosphorylation site [posttranslational modification] 436717000301 intermolecular recognition site; other site 436717000302 dimerization interface [polypeptide binding]; other site 436717000303 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 436717000304 DNA binding site [nucleotide binding] 436717000305 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 436717000306 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 436717000307 short chain dehydrogenase; Provisional; Region: PRK06181 436717000308 NAD(P) binding site [chemical binding]; other site 436717000309 active site 436717000310 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 436717000311 MatE; Region: MatE; pfam01554 436717000312 MatE; Region: MatE; pfam01554 436717000313 methionine aminotransferase; Validated; Region: PRK09082 436717000314 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 436717000315 pyridoxal 5'-phosphate binding site [chemical binding]; other site 436717000316 homodimer interface [polypeptide binding]; other site 436717000317 catalytic residue [active] 436717000318 Protein of unknown function (DUF445); Region: DUF445; pfam04286 436717000319 Bacterial protein of unknown function (DUF924); Region: DUF924; cl01561 436717000320 Glutamate-cysteine ligase; Region: Glu_cys_ligase; cl01099 436717000321 Disulfide bond formation protein DsbB; Region: DsbB; cl00649 436717000322 Uncharacterized protein conserved in bacteria [Function unknown]; Region: VgrG; COG3501 436717000323 Phage-related baseplate assembly protein; Region: Phage_base_V; cl11432 436717000324 Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; cl01733 436717000325 Protein of unknown function (DUF1311); Region: DUF1311; cl01530 436717000326 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 436717000327 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 436717000328 Uncharacterised protein family (UPF0227); Region: UPF0227; cl14886 436717000329 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 436717000330 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 436717000331 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 436717000332 ATP binding site [chemical binding]; other site 436717000333 Mg2+ binding site [ion binding]; other site 436717000334 G-X-G motif; other site 436717000335 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are...; Region: TopoII_Trans_DNA_gyrase; cd00822 436717000336 anchoring element; other site 436717000337 dimer interface [polypeptide binding]; other site 436717000338 ATP binding site [chemical binding]; other site 436717000339 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 436717000340 active site 436717000341 metal binding site [ion binding]; metal-binding site 436717000342 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 436717000343 Ureidoglycolate hydrolase; Region: Ureidogly_hydro; cl01250 436717000344 Ureidoglycolate hydrolase [Nucleotide transport and metabolism]; Region: DAL3; COG3194 436717000345 allantoicase; Provisional; Region: PRK13257 436717000346 Allantoicase repeat; Region: Allantoicase; pfam03561 436717000347 Allantoicase repeat; Region: Allantoicase; pfam03561 436717000348 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 436717000349 FAD binding domain; Region: FAD_binding_3; pfam01494 436717000350 Nucleoside-specific channel-forming protein, Tsx; Region: Channel_Tsx; cl04114 436717000351 Permease family; Region: Xan_ur_permease; pfam00860 436717000352 Sulfate transporter family; Region: Sulfate_transp; cl00967 436717000353 HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU)...; Region: TLP_HIUase; cd05822 436717000354 active site 436717000355 homotetramer interface [polypeptide binding]; other site 436717000356 OHCU decarboxylase; Region: OHCU_decarbox; cl01251 436717000357 putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212 436717000358 Polysaccharide deacetylase; Region: Polysacc_deac_1; cl12061 436717000359 RaiA ('ribosome-associated inhibitor A', also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal A site...; Region: RaiA; cl00250 436717000360 30S subunit binding site; other site 436717000361 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 436717000362 thiol:disulfide interchange protein precursor; Provisional; Region: dipZ; PRK00293 436717000363 Disulphide bond corrector protein DsbC; Region: DsbC; pfam11412 436717000364 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl00515 436717000365 DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953 436717000366 DsbD alpha interface [polypeptide binding]; other site 436717000367 catalytic residues [active] 436717000368 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 436717000369 metal binding site [ion binding]; metal-binding site 436717000370 active site 436717000371 I-site; other site 436717000372 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 436717000373 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 436717000374 Glutathionylspermidine synthase; Region: GSP_synth; cl00503 436717000375 Uncharacterized protein conserved in bacteria (DUF2147); Region: DUF2147; cl01951 436717000376 Arsenate Reductase (ArsC) family, Yffb subfamily; Yffb is an uncharacterized bacterial protein encoded by the yffb gene, related to the thioredoxin-fold arsenic reductases, ArsC. The structure of Yffb and the conservation of the catalytic cysteine...; Region: ArsC_Yffb; cd03035 436717000377 putative catalytic residues [active] 436717000378 Neisseria meningitides Nape-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Nape_like_AP-endo; cd10281 436717000379 putative active site [active] 436717000380 putative DNA binding site [nucleotide binding]; other site 436717000381 putative phosphate binding site [ion binding]; other site 436717000382 putative catalytic site [active] 436717000383 metal binding site A [ion binding]; metal-binding site 436717000384 putative AP binding site [nucleotide binding]; other site 436717000385 putative metal binding site B [ion binding]; other site 436717000386 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 436717000387 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 436717000388 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 436717000389 N-terminal plug; other site 436717000390 ligand-binding site [chemical binding]; other site 436717000391 Domain of unknown function (DUF1737); Region: DUF1737; cl10503 436717000392 glutathione synthetase; Provisional; Region: PRK05246 436717000393 Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951 436717000394 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 436717000395 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 436717000396 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl...; Region: GT1_MurG; cd03785 436717000397 active site 436717000398 homodimer interface [polypeptide binding]; other site 436717000399 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 436717000400 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 436717000401 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 436717000402 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 436717000403 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 436717000404 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 436717000405 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 436717000406 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 436717000407 Cell division protein FtsQ; Region: FtsQ; pfam03799 436717000408 cell division protein FtsA; Region: ftsA; TIGR01174 436717000409 Cell division protein FtsA; Region: FtsA; cl11496 436717000410 Cell division protein FtsA; Region: FtsA; cl11496 436717000411 cell division protein FtsZ; Validated; Region: PRK09330 436717000412 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum...; Region: FtsZ_type1; cd02201 436717000413 nucleotide binding site [chemical binding]; other site 436717000414 SulA interaction site; other site 436717000415 UDP-3-O-acyl-N-acetylglucosamine deacetylase [Cell envelope biogenesis, outer membrane]; Region: LpxC; cl00512 436717000416 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 436717000417 Peptidase family M23; Region: Peptidase_M23; pfam01551 436717000418 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 436717000419 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 436717000420 dimer interface [polypeptide binding]; other site 436717000421 TPP-binding site [chemical binding]; other site 436717000422 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 436717000423 pyruvate dehydrogenase dihydrolipoyltransacetylase; Validated; Region: aceF; PRK11854 436717000424 E3 interaction surface; other site 436717000425 lipoyl attachment site [posttranslational modification]; other site 436717000426 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 436717000427 E3 interaction surface; other site 436717000428 lipoyl attachment site [posttranslational modification]; other site 436717000429 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 436717000430 E3 interaction surface; other site 436717000431 lipoyl attachment site [posttranslational modification]; other site 436717000432 e3 binding domain; Region: E3_binding; pfam02817 436717000433 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008 436717000434 Predicted membrane protein [Function unknown]; Region: COG2119 436717000435 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 436717000436 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 436717000437 ferrichrome receptor precursor protein; Provisional; Region: PRK14050 436717000438 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 436717000439 N-terminal plug; other site 436717000440 ligand-binding site [chemical binding]; other site 436717000441 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 436717000442 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 436717000443 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 436717000444 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a key...; Region: CBS_pair_IMPDH; cd04601 436717000445 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of the...; Region: IMPDH; cd00381 436717000446 active site 436717000447 phosphoglucosamine mutase; Provisional; Region: glmM; PRK10887 436717000448 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of UDP-N-...; Region: GlmM; cd05802 436717000449 active site 436717000450 substrate binding site [chemical binding]; other site 436717000451 metal binding site [ion binding]; metal-binding site 436717000452 pyridoxamine-phosphate oxidase; Region: pdxH; TIGR00558 436717000453 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 436717000454 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 436717000455 ssDNA exonuclease RecJ; Provisional; Region: PRK11070 436717000456 DHH family; Region: DHH; pfam01368 436717000457 DHHA1 domain; Region: DHHA1; pfam02272 436717000458 peptide chain release factor 2; Provisional; Region: PRK08787 436717000459 RF-1 domain; Region: RF-1; cl02875 436717000460 RF-1 domain; Region: RF-1; cl02875 436717000461 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 436717000462 putative DNA binding site [nucleotide binding]; other site 436717000463 dimerization interface [polypeptide binding]; other site 436717000464 putative Zn2+ binding site [ion binding]; other site 436717000465 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 436717000466 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 436717000467 FMN binding site [chemical binding]; other site 436717000468 active site 436717000469 substrate binding site [chemical binding]; other site 436717000470 catalytic residue [active] 436717000471 3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749 436717000472 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 436717000473 Glycosyl transferases group 1; Region: Glycos_transf_1; cl12012 436717000474 RNA methyltransferase; Region: Methyltrans_RNA; cl00611 436717000475 Mechanosensitive ion channel; Region: MS_channel; pfam00924 436717000476 Protein of unknown function (DUF805); Region: DUF805; cl01224 436717000477 acetyl-CoA synthetase; Provisional; Region: PRK00174 436717000478 Domain of unknown function (DUF3448); Region: DUF3448; pfam11930 436717000479 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 436717000480 Isochorismatase family; Region: Isochorismatase; pfam00857 436717000481 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 436717000482 catalytic triad [active] 436717000483 conserved cis-peptide bond; other site 436717000484 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 436717000485 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 436717000486 active site 436717000487 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 436717000488 dimer interface [polypeptide binding]; other site 436717000489 non-prolyl cis peptide bond; other site 436717000490 insertion regions; other site 436717000491 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 436717000492 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 436717000493 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 436717000494 active site 436717000495 phosphorylation site [posttranslational modification] 436717000496 intermolecular recognition site; other site 436717000497 dimerization interface [polypeptide binding]; other site 436717000498 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 436717000499 DNA binding residues [nucleotide binding] 436717000500 dimerization interface [polypeptide binding]; other site 436717000501 Sodium:solute symporter family; Region: SSF; cl00456 436717000502 PAS fold; Region: PAS_7; pfam12860 436717000503 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 436717000504 dimer interface [polypeptide binding]; other site 436717000505 phosphorylation site [posttranslational modification] 436717000506 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 436717000507 ATP binding site [chemical binding]; other site 436717000508 Mg2+ binding site [ion binding]; other site 436717000509 G-X-G motif; other site 436717000510 Response regulator receiver domain; Region: Response_reg; pfam00072 436717000511 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 436717000512 active site 436717000513 phosphorylation site [posttranslational modification] 436717000514 intermolecular recognition site; other site 436717000515 dimerization interface [polypeptide binding]; other site 436717000516 Protein of unknown function, DUF485; Region: DUF485; cl01231 436717000517 Sodium:solute symporter family; Region: SSF; cl00456 436717000518 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 436717000519 BCCT family transporter; Region: BCCT; cl00569 436717000520 choline transport protein BetT; Provisional; Region: PRK09928 436717000521 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 436717000522 metal binding site [ion binding]; metal-binding site 436717000523 active site 436717000524 I-site; other site 436717000525 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 436717000526 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 436717000527 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 436717000528 The excision repair protein UvrA domain II; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_II; cd03271 436717000529 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 436717000530 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 436717000531 2-enoyl thioester reductase (ETR) like proteins, child 2; Region: ETR_like_2; cd08292 436717000532 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 436717000533 putative NAD(P) binding site [chemical binding]; other site 436717000534 putative dimer interface [polypeptide binding]; other site 436717000535 Protein of unknown function (DUF1304); Region: DUF1304; cl01533 436717000536 GlpM protein; Region: GlpM; cl01212 436717000537 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 436717000538 classical (c) SDRs; Region: SDR_c; cd05233 436717000539 NAD(P) binding site [chemical binding]; other site 436717000540 active site 436717000541 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 436717000542 DNA binding residues [nucleotide binding] 436717000543 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cl15243 436717000544 Integral membrane protein TerC family; Region: TerC; cl10468 436717000545 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 436717000546 Major Facilitator Superfamily; Region: MFS_1; pfam07690 436717000547 putative substrate translocation pore; other site 436717000548 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 436717000549 dimer interface [polypeptide binding]; other site 436717000550 ssDNA binding site [nucleotide binding]; other site 436717000551 tetramer (dimer of dimers) interface [polypeptide binding]; other site 436717000552 AzlC protein; Region: AzlC; cl00570 436717000553 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 436717000554 non-specific DNA binding site [nucleotide binding]; other site 436717000555 salt bridge; other site 436717000556 sequence-specific DNA binding site [nucleotide binding]; other site 436717000557 Cupin domain; Region: Cupin_2; cl09118 436717000558 Transmembrane amino acid transporter protein; Region: Aa_trans; cl00524 436717000559 Amino acid permease; Region: AA_permease; pfam00324 436717000560 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 436717000561 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 436717000562 DNA-binding site [nucleotide binding]; DNA binding site 436717000563 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 436717000564 pyridoxal 5'-phosphate binding site [chemical binding]; other site 436717000565 homodimer interface [polypeptide binding]; other site 436717000566 catalytic residue [active] 436717000567 4-aminobutyrate aminotransferase; Provisional; Region: PRK06777 436717000568 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase...; Region: OAT_like; cd00610 436717000569 inhibitor-cofactor binding pocket; inhibition site 436717000570 pyridoxal 5'-phosphate binding site [chemical binding]; other site 436717000571 catalytic residue [active] 436717000572 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 436717000573 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 436717000574 tetramerization interface [polypeptide binding]; other site 436717000575 NAD(P) binding site [chemical binding]; other site 436717000576 catalytic residues [active] 436717000577 LysR family transcriptional regulator; Provisional; Region: PRK14997 436717000578 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 436717000579 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 436717000580 dimerization interface [polypeptide binding]; other site 436717000581 Isochorismatase family; Region: Isochorismatase; pfam00857 436717000582 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them...; Region: YcaC_related; cd01012 436717000583 catalytic triad [active] 436717000584 dimer interface [polypeptide binding]; other site 436717000585 conserved cis-peptide bond; other site 436717000586 Pirin-related protein [General function prediction only]; Region: COG1741 436717000587 Cupin domain; Region: Cupin_2; cl09118 436717000588 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 436717000589 Predicted NAD/FAD-binding protein [General function prediction only]; Region: COG2907 436717000590 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 436717000591 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 436717000592 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 436717000593 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 436717000594 Glutathione-dependent formaldehyde-activating enzyme; Region: GFA; cl01553 436717000595 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 436717000596 putative active site pocket [active] 436717000597 dimerization interface [polypeptide binding]; other site 436717000598 putative catalytic residue [active] 436717000599 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 436717000600 putative substrate translocation pore; other site 436717000601 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 436717000602 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 436717000603 The C-terminal substrate binding domain of LysR-type transcrptional regulator BudR, which is responsible for activation of the expression of the butanediol operon genes; contains the type 2 periplasmic binding fold; Region: PBP2_BudR; cd08451 436717000604 putative dimerization interface [polypeptide binding]; other site 436717000605 putative substrate binding pocket [chemical binding]; other site 436717000606 Pyoverdine/dityrosine biosynthesis protein; Region: DIT1_PvcA; pfam05141 436717000607 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 436717000608 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG...; Region: CAS_like; cl00184 436717000609 substrate binding pocket [chemical binding]; other site 436717000610 active site 436717000611 iron coordination sites [ion binding]; other site 436717000612 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 436717000613 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 436717000614 Outer membrane efflux protein; Region: OEP; pfam02321 436717000615 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 436717000616 Predicted permeases [General function prediction only]; Region: RarD; COG2962 436717000617 EamA-like transporter family; Region: EamA; cl01037 436717000618 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 436717000619 catalytic loop [active] 436717000620 iron binding site [ion binding]; other site 436717000621 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron...; Region: FNR_like; cl06868 436717000622 FAD binding pocket [chemical binding]; other site 436717000623 conserved FAD binding motif [chemical binding]; other site 436717000624 phosphate binding motif [ion binding]; other site 436717000625 beta-alpha-beta structure motif; other site 436717000626 NAD binding pocket [chemical binding]; other site 436717000627 argininosuccinate lyase; Provisional; Region: PRK02186 436717000628 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 436717000629 Domain of unknown function (DUF1297); Region: DUF1297; pfam06973 436717000630 argininosuccinate lyase; Provisional; Region: PRK02186 436717000631 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 436717000632 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and...; Region: Aldo_ket_red; cd06660 436717000633 active site 436717000634 catalytic tetrad [active] 436717000635 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 436717000636 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 436717000637 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 436717000638 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 436717000639 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 436717000640 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 436717000641 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 436717000642 conserved cys residue [active] 436717000643 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 436717000644 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 436717000645 potassium uptake protein; Region: kup; TIGR00794 436717000646 K+ potassium transporter; Region: K_trans; cl01227 436717000647 DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases. They exists as monomers and homodimers; Region: NUC; cd00091 436717000648 active site 436717000649 substrate binding site [chemical binding]; other site 436717000650 Mg2+ binding site [ion binding]; other site 436717000651 LysE type translocator; Region: LysE; cl00565 436717000652 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-...; Region: MIP; cd00333 436717000653 amphipathic channel; other site 436717000654 Asn-Pro-Ala signature motifs; other site 436717000655 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 436717000656 Helix-turn-helix domain; Region: HTH_18; pfam12833 436717000657 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 436717000658 Imidazoleglycerol-phosphate synthase [Amino acid transport and metabolism]; Region: HisF; COG0107 436717000659 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)-formimino-5-; Region: HisF; cd04731 436717000660 substrate binding site [chemical binding]; other site 436717000661 glutamase interaction surface [polypeptide binding]; other site 436717000662 Homoserine Kinase, type II. Homoserine kinase is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and...; Region: HomoserineK_II; cd05153 436717000663 Phosphotransferase enzyme family; Region: APH; pfam01636 436717000664 putative active site [active] 436717000665 putative substrate binding site [chemical binding]; other site 436717000666 ATP binding site [chemical binding]; other site 436717000667 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein...; Region: CSP_CDS; cd04458 436717000668 DNA-binding site [nucleotide binding]; DNA binding site 436717000669 RNA-binding motif; other site 436717000670 Protein of unknown function (DUF1294); Region: DUF1294; cl01311 436717000671 Predicted membrane protein [Function unknown]; Region: COG3671 436717000672 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 436717000673 EamA-like transporter family; Region: EamA; cl01037 436717000674 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 436717000675 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 436717000676 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 436717000677 non-specific DNA binding site [nucleotide binding]; other site 436717000678 salt bridge; other site 436717000679 sequence-specific DNA binding site [nucleotide binding]; other site 436717000680 Cupin domain; Region: Cupin_2; cl09118 436717000681 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 436717000682 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 436717000683 Walker A/P-loop; other site 436717000684 ATP binding site [chemical binding]; other site 436717000685 Q-loop/lid; other site 436717000686 ABC transporter signature motif; other site 436717000687 Walker B; other site 436717000688 D-loop; other site 436717000689 H-loop/switch region; other site 436717000690 Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase [Amino acid transport and metabolism]; Region: HisA; COG0106 436717000691 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1'-...; Region: HisA; cd04732 436717000692 catalytic residues [active] 436717000693 DEDDy 3'-5' exonuclease domain of WRN and similar proteins; Region: WRN_exo; cd06141 436717000694 putative active site [active] 436717000695 catalytic site [active] 436717000696 putative substrate binding site [chemical binding]; other site 436717000697 Protein of unknown function (DUF805); Region: DUF805; cl01224 436717000698 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141 436717000699 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 436717000700 putative active site [active] 436717000701 oxyanion strand; other site 436717000702 catalytic triad [active] 436717000703 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 436717000704 putative active site pocket [active] 436717000705 4-fold oligomerization interface [polypeptide binding]; other site 436717000706 metal binding residues [ion binding]; metal-binding site 436717000707 3-fold/trimer interface [polypeptide binding]; other site 436717000708 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 436717000709 Coenzyme A binding pocket [chemical binding]; other site 436717000710 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 436717000711 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 436717000712 Coenzyme A binding pocket [chemical binding]; other site 436717000713 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 436717000714 succinate CoA transferases; Region: YgfH_subfam; TIGR03458 436717000715 Coenzyme A transferase; Region: CoA_trans; cl00773 436717000716 osmolarity sensor protein; Provisional; Region: envZ; PRK09467 436717000717 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 436717000718 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 436717000719 dimer interface [polypeptide binding]; other site 436717000720 phosphorylation site [posttranslational modification] 436717000721 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 436717000722 ATP binding site [chemical binding]; other site 436717000723 Mg2+ binding site [ion binding]; other site 436717000724 G-X-G motif; other site 436717000725 osmolarity response regulator; Provisional; Region: ompR; PRK09468 436717000726 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 436717000727 active site 436717000728 phosphorylation site [posttranslational modification] 436717000729 intermolecular recognition site; other site 436717000730 dimerization interface [polypeptide binding]; other site 436717000731 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 436717000732 DNA binding site [nucleotide binding] 436717000733 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 436717000734 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 436717000735 Uncharacterised protein family (UPF0081); Region: UPF0081; cl00525 436717000736 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin...; Region: S1_Tex; cd05685 436717000737 RNA binding site [nucleotide binding]; other site 436717000738 putative transporter; Provisional; Region: PRK11660 436717000739 Sulfate transporter family; Region: Sulfate_transp; cl00967 436717000740 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378 436717000741 active site clefts [active] 436717000742 zinc binding site [ion binding]; other site 436717000743 dimer interface [polypeptide binding]; other site 436717000744 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 436717000745 classical (c) SDRs; Region: SDR_c; cd05233 436717000746 NAD(P) binding site [chemical binding]; other site 436717000747 active site 436717000748 Uncharacterised protein family (UPF0093); Region: UPF0093; cl00863 436717000749 Domain of unknown function (DUF3817); Region: DUF3817; cl14844 436717000750 transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393 436717000751 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 436717000752 conserved cys residue [active] 436717000753 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 436717000754 O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK06084 436717000755 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 436717000756 homodimer interface [polypeptide binding]; other site 436717000757 substrate-cofactor binding pocket; other site 436717000758 pyridoxal 5'-phosphate binding site [chemical binding]; other site 436717000759 catalytic residue [active] 436717000760 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 436717000761 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by...; Region: ABCF_EF-3; cd03221 436717000762 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 436717000763 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by...; Region: ABCF_EF-3; cd03221 436717000764 ABC transporter; Region: ABC_tran_2; pfam12848 436717000765 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by...; Region: ABCF_EF-3; cd03221 436717000766 Sel1 repeat; Region: Sel1; cl02723 436717000767 hypothetical protein; Provisional; Region: PRK10215 436717000768 Outer membrane efflux protein; Region: OEP; pfam02321 436717000769 Outer membrane efflux protein; Region: OEP; pfam02321 436717000770 pyruvate carboxylase; Reviewed; Region: PRK12999 436717000771 Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999 436717000772 heavy metal efflux pump (cobalt-zinc-cadmium); Region: 2A0601; TIGR00914 436717000773 Cation efflux family; Region: Cation_efflux; cl00316 436717000774 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 436717000775 Transmembrane amino acid transporter protein; Region: Aa_trans; cl00524 436717000776 Amino acid permease; Region: AA_permease; pfam00324 436717000777 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 436717000778 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 436717000779 active site 436717000780 HIGH motif; other site 436717000781 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 436717000782 active site 436717000783 KMSKS motif; other site 436717000784 ABC-type thiamine transport system, periplasmic component [Coenzyme metabolism]; Region: TbpA; COG4143 436717000785 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 436717000786 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 436717000787 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 436717000788 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 436717000789 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275 436717000790 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 436717000791 Septum formation initiator; Region: DivIC; cl11433 436717000792 peptidoglycan synthase FtsI; Provisional; Region: PRK15105 436717000793 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 436717000794 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01039 436717000795 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 436717000796 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 436717000797 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 436717000798 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 436717000799 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 436717000800 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Region: murF; TIGR01143 436717000801 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 436717000802 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 436717000803 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of undecaprenyl-pyrophosphoryl-N-...; Region: GT_MraY; cd06852 436717000804 Mg++ binding site [ion binding]; other site 436717000805 putative catalytic motif [active] 436717000806 putative substrate binding site [chemical binding]; other site 436717000807 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 436717000808 S-adenosylmethionine binding site [chemical binding]; other site 436717000809 penicillin-binding protein 1a; Provisional; Region: mrcA; PRK11636 436717000810 Transglycosylase; Region: Transgly; cl07896 436717000811 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01039 436717000812 Competence protein A; Region: Competence_A; pfam11104 436717000813 Tfp pilus assembly protein PilN [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilN; COG3166 436717000814 Fimbrial assembly protein (PilN); Region: PilN; pfam05137 436717000815 Pilus assembly protein, PilO; Region: PilO; cl01234 436717000816 Pilus assembly protein, PilP; Region: PilP; cl01235 436717000817 type IV pilus secretin (or competence protein) PilQ; Region: IV_pilus_PilQ; TIGR02515 436717000818 Secretin and TonB N terminus short domain; Region: STN; pfam07660 436717000819 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 436717000820 Bacterial type II and III secretion system protein; Region: Secretin; cl02829 436717000821 shikimate kinase; Reviewed; Region: aroK; PRK00131 436717000822 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the...; Region: SK; cd00464 436717000823 ADP binding site [chemical binding]; other site 436717000824 magnesium binding site [ion binding]; other site 436717000825 putative shikimate binding site; other site 436717000826 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 436717000827 active site 436717000828 dimer interface [polypeptide binding]; other site 436717000829 metal binding site [ion binding]; metal-binding site 436717000830 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 436717000831 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The N-...; Region: GltS; cd00713 436717000832 active site 436717000833 dimer interface [polypeptide binding]; other site 436717000834 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 436717000835 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant...; Region: GltS_FMN; cd02808 436717000836 active site 436717000837 FMN binding site [chemical binding]; other site 436717000838 substrate binding site [chemical binding]; other site 436717000839 3Fe-4S cluster binding site [ion binding]; other site 436717000840 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 436717000841 domain interface; other site 436717000842 glutamate synthase small subunit family protein, proteobacterial; Region: gltD_gamma_fam; TIGR01318 436717000843 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 436717000844 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 436717000845 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687 436717000846 Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118 436717000847 LemA family; Region: LemA; cl00742 436717000848 Domain of unknown function (DUF477); Region: DUF477; cl01535 436717000849 Domain of unknown function (DUF477); Region: DUF477; cl01535 436717000850 Tfp pilus assembly protein, major pilin PilA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilA; COG4969 436717000851 Pilin (bacterial filament); Region: Pilin; pfam00114 436717000852 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 436717000853 O-Antigen ligase; Region: Wzy_C; cl04850 436717000854 Domain of unknown function (DUF3366); Region: DUF3366; pfam11846 436717000855 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 436717000856 Ferritin-like domain; Region: Ferritin; pfam00210 436717000857 heme binding site [chemical binding]; other site 436717000858 ferroxidase pore; other site 436717000859 ferroxidase diiron center [ion binding]; other site 436717000860 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; cl01093 436717000861 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 436717000862 homotrimer interaction site [polypeptide binding]; other site 436717000863 putative active site [active] 436717000864 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 436717000865 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 436717000866 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 436717000867 synthetase active site [active] 436717000868 NTP binding site [chemical binding]; other site 436717000869 metal binding site [ion binding]; metal-binding site 436717000870 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named...; Region: TGS_RelA_SpoT; cd01668 436717000871 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 436717000872 RNA polymerase Rpb6; Region: RNA_pol_Rpb6; cl14651 436717000873 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and...; Region: GMPK; cd00071 436717000874 catalytic site [active] 436717000875 G-X2-G-X-G-K; other site 436717000876 LytB protein; Region: LYTB; cl00507 436717000877 (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate reductase (IPP and DMAPP forming); Region: ispH_lytB; TIGR00216 436717000878 Tfp pilus assembly protein FimT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimT; COG4970 436717000879 type IV pilus modification protein PilV; Region: type_IV_pilV; TIGR02523 436717000880 Tfp pilus assembly protein PilW [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilW; COG4966 436717000881 Tfp pilus assembly protein, tip-associated adhesin PilY1 [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilY1; COG3419 436717000882 Tfp pilus assembly protein PilE [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilE; COG4968 436717000883 Tfp pilus assembly protein PilE [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilE; COG4968 436717000884 Ribosomal protein S16; Region: Ribosomal_S16; cl00368 436717000885 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 436717000886 RimM N-terminal domain; Region: RimM; pfam01782 436717000887 Photosynthetic reaction center (RC) complex, subunit H; RC is an integral membrane protein-pigment complex which catalyzes light-induced reduction of ubiquinone to ubiquinol, generating a transmembrane electrochemical gradient of protons used to...; Region: PRCH; cl09959 436717000888 tRNA (Guanine-1)-methyltransferase; Region: tRNA_m1G_MT; cl00407 436717000889 Ribosomal protein L19; Region: Ribosomal_L19; cl00406 436717000890 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 436717000891 Putative serine esterase (DUF676); Region: DUF676; pfam05057 436717000892 lipase chaperone; Provisional; Region: PRK01294 436717000893 Proteobacterial lipase chaperone protein; Region: Lipase_chap; cl02224 436717000894 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05033 436717000895 PseudoU_synth_EcTruB: Pseudouridine synthase, Escherichia coli TruB like. This group consists of bacterial pseudouridine synthases similar to E. coli TruB and Mycobacterium tuberculosis TruB. Pseudouridine synthases catalyze the isomerization of...; Region: PseudoU_synth_EcTruB; cd02573 436717000896 RNA binding site [nucleotide binding]; other site 436717000897 active site 436717000898 Predicted permeases [General function prediction only]; Region: COG0730; cl00498 436717000899 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 436717000900 Threonine/homoserine efflux transporter [Amino acid transport and metabolism]; Region: rhtA; COG5006 436717000901 threonine and homoserine efflux system; Provisional; Region: PRK10532 436717000902 EamA-like transporter family; Region: EamA; cl01037 436717000903 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790 436717000904 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 436717000905 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 436717000906 L-serine binding site [chemical binding]; other site 436717000907 ACT domain interface; other site 436717000908 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 436717000909 FAD binding domain; Region: FAD_binding_4; pfam01565 436717000910 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 436717000911 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 436717000912 Domain of unknown function (DUF477); Region: DUF477; cl01535 436717000913 multidrug efflux system translocase MdfA; Provisional; Region: PRK15402 436717000914 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 436717000915 putative substrate translocation pore; other site 436717000916 hypothetical membrane protein, TIGR01666; Region: YCCS 436717000917 FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805 436717000918 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 436717000919 E-class dimer interface [polypeptide binding]; other site 436717000920 P-class dimer interface [polypeptide binding]; other site 436717000921 active site 436717000922 Cu2+ binding site [ion binding]; other site 436717000923 Zn2+ binding site [ion binding]; other site 436717000924 Domain of unknown function DUF20; Region: UPF0118; cl00465 436717000925 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 436717000926 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following...; Region: ParA; cd02042 436717000927 P-loop; other site 436717000928 Magnesium ion binding site [ion binding]; other site 436717000929 Endonuclease related to archaeal Holliday junction resolvase; Region: Endonuc_Holl; cl01958 436717000930 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 436717000931 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 436717000932 S-adenosylmethionine binding site [chemical binding]; other site 436717000933 Transmembrane amino acid transporter protein; Region: Aa_trans; cl00524 436717000934 Amino acid permease; Region: AA_permease; pfam00324 436717000935 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 436717000936 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 436717000937 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 436717000938 NAD(P) binding site [chemical binding]; other site 436717000939 bifunctional succinylornithine transaminase/acetylornithine transaminase; Provisional; Region: PRK12381 436717000940 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase...; Region: OAT_like; cd00610 436717000941 inhibitor-cofactor binding pocket; inhibition site 436717000942 pyridoxal 5'-phosphate binding site [chemical binding]; other site 436717000943 catalytic residue [active] 436717000944 Arginine N-succinyltransferase beta subunit; Region: AstA; cl11440 436717000945 Arginine/ornithine N-succinyltransferase beta subunit [Amino acid transport and metabolism]; Region: AstA; COG3138 436717000946 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 436717000947 N-succinylglutamate 5-semialdehyde dehydrogenase, AstD-like; Region: ALDH_SGSD_AstD; cd07095 436717000948 NAD(P) binding site [chemical binding]; other site 436717000949 catalytic residues [active] 436717000950 Succinylarginine dihydrolase; Region: AstB; cl01511 436717000951 Peptidase M14 Succinylglutamate desuccinylase (ASTE, also known as N-succinyl-L-glutamate amidohydrolase, N2-succinylglutamate desuccinylase, and SGDS; EC 3.5.1.96) belongs to the Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA) subfamily...; Region: M14_ASTE; cd03855 436717000952 Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952 436717000953 putative active site [active] 436717000954 Zn-binding site [ion binding]; other site 436717000955 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 436717000956 active site 436717000957 catalytic residues [active] 436717000958 Transcriptional regulator [Transcription]; Region: LysR; COG0583 436717000959 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 436717000960 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 436717000961 dimerization interface [polypeptide binding]; other site 436717000962 EamA-like transporter family; Region: EamA; cl01037 436717000963 EamA-like transporter family; Region: EamA; cl01037 436717000964 YCII-related domain; Region: YCII; cl00999 436717000965 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 436717000966 Glycyl-tRNA synthetase beta subunit; Region: tRNA_synt_2f; pfam02092 436717000967 glycyl-tRNA synthetase, tetrameric type, alpha subunit; Region: glyQ; TIGR00388 436717000968 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 436717000969 dimer interface [polypeptide binding]; other site 436717000970 motif 1; other site 436717000971 active site 436717000972 motif 2; other site 436717000973 motif 3; other site 436717000974 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 436717000975 Sel1 repeat; Region: Sel1; cl02723 436717000976 Protein of unknown function (DUF1311); Region: DUF1311; cl01530 436717000977 putative DNA modification/repair radical SAM protein; Region: rSAM_link_UDG; TIGR03916 436717000978 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 436717000979 FeS/SAM binding site; other site 436717000980 probable DNA metabolism protein; Region: SAM_7_link_chp; TIGR03915 436717000981 CBS-domain-containing membrane protein [Signal transduction mechanisms]; Region: COG3448 436717000982 HPP family; Region: HPP; pfam04982 436717000983 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the HPP motif domain. These proteins are integral membrane proteins with four transmembrane spanning helices. The function of these proteins is...; Region: CBS_pair_HPP_assoc; cd04600 436717000984 PspC domain; Region: PspC; cl00864 436717000985 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 436717000986 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 436717000987 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 436717000988 active site 436717000989 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 436717000990 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 436717000991 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 436717000992 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 436717000993 shikimate binding site; other site 436717000994 NAD(P) binding site [chemical binding]; other site 436717000995 Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; cl00433 436717000996 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 436717000997 GTP cyclohydrolase II [Coenzyme metabolism]; Region: RibA; COG0807 436717000998 dimerization interface [polypeptide binding]; other site 436717000999 active site 436717001000 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 436717001001 TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products with important pharmaceutical activity. DXS...; Region: TPP_DXS; cd02007 436717001002 TPP-binding site; other site 436717001003 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 436717001004 PYR/PP interface [polypeptide binding]; other site 436717001005 dimer interface [polypeptide binding]; other site 436717001006 TPP binding site [chemical binding]; other site 436717001007 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 436717001008 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 436717001009 active site 436717001010 dimerization interface [polypeptide binding]; other site 436717001011 ATP-dependent RNA helicase RhlB; Provisional; Region: PRK04837 436717001012 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (...; Region: DEADc; cd00268 436717001013 ATP binding site [chemical binding]; other site 436717001014 Mg++ binding site [ion binding]; other site 436717001015 motif III; other site 436717001016 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 436717001017 nucleotide binding region [chemical binding]; other site 436717001018 ATP-binding site [chemical binding]; other site 436717001019 transcription termination factor Rho; Provisional; Region: PRK12678 436717001020 putative ABC transporter ATP-binding protein YrbF; Provisional; Region: PRK11831 436717001021 ABC (ATP-binding cassette) transport system involved in resistant to organic solvents; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex...; Region: ABC_Org_Solvent_Resistant; cd03261 436717001022 Walker A/P-loop; other site 436717001023 ATP binding site [chemical binding]; other site 436717001024 Q-loop/lid; other site 436717001025 ABC transporter signature motif; other site 436717001026 Walker B; other site 436717001027 D-loop; other site 436717001028 H-loop/switch region; other site 436717001029 Domain of unknown function DUF140; Region: DUF140; cl00510 436717001030 mce related protein; Region: MCE; cl03606 436717001031 ABC-type transport system involved in resistance to organic solvents, auxiliary component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2D; cl01074 436717001032 Toluene tolerance, Ttg2; Region: Tol_Tol_Ttg2; pfam05494 436717001033 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 436717001034 anti sigma factor interaction site; other site 436717001035 regulatory phosphorylation site [posttranslational modification]; other site 436717001036 magnesium/nickel/cobalt transporter CorA; Provisional; Region: PRK11085; cl00459 436717001037 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 436717001038 DNA recombination-mediator protein A; Region: DNA_processg_A; cl00695 436717001039 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_31; cd04690 436717001040 nudix motif; other site 436717001041 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 436717001042 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 436717001043 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a four-...; Region: RecG_wedge_OBF; cd04488 436717001044 ssDNA binding site; other site 436717001045 generic binding surface II; other site 436717001046 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 436717001047 ATP binding site [chemical binding]; other site 436717001048 putative Mg++ binding site [ion binding]; other site 436717001049 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 436717001050 nucleotide binding region [chemical binding]; other site 436717001051 ATP-binding site [chemical binding]; other site 436717001052 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 436717001053 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 436717001054 NAD(P) binding site [chemical binding]; other site 436717001055 active site 436717001056 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 436717001057 potential frameshift: common BLAST hit: gi|169632340|ref|YP_001706076.1| glycerol-3-phosphate acyltransferase 436717001058 Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946 436717001059 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 436717001060 active site 436717001061 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 436717001062 catalytic triad [active] 436717001063 dimer interface [polypeptide binding]; other site 436717001064 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 436717001065 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687 436717001066 Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118 436717001067 The YihA (EngB) subfamily. This subfamily of GTPases is typified by the E. coli YihA, an essential protein involved in cell division control. YihA and its orthologs are small proteins that typically contain less than 200 amino acid residues and...; Region: YihA_EngB; cd01876 436717001068 G1 box; other site 436717001069 GTP/Mg2+ binding site [chemical binding]; other site 436717001070 Switch I region; other site 436717001071 G2 box; other site 436717001072 G3 box; other site 436717001073 Switch II region; other site 436717001074 G4 box; other site 436717001075 G5 box; other site 436717001076 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 436717001077 Rrf2 family protein; Region: rrf2_super; TIGR00738 436717001078 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 436717001079 heme-binding site [chemical binding]; other site 436717001080 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron...; Region: FNR_like; cl06868 436717001081 FAD binding pocket [chemical binding]; other site 436717001082 conserved FAD binding motif [chemical binding]; other site 436717001083 phosphate binding motif [ion binding]; other site 436717001084 Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872 436717001085 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 436717001086 Walker A motif; other site 436717001087 ATP binding site [chemical binding]; other site 436717001088 Walker B motif; other site 436717001089 cystathionine beta-lyase; Provisional; Region: PRK07050 436717001090 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 436717001091 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 436717001092 catalytic residue [active] 436717001093 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 436717001094 catalytic triad [active] 436717001095 Ribosomal protein S10p/S20e; Region: Ribosomal_S10; cl00314 436717001096 Ribosomal protein L3; Region: Ribosomal_L3; cl00324 436717001097 Ribosomal protein L4/L1 family; Region: Ribosomal_L4; cl00325 436717001098 Ribosomal protein L23; Region: Ribosomal_L23; cl00326 436717001099 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 436717001100 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 436717001101 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 436717001102 Ribosomal protein S19; Region: Ribosomal_S19; cl00350 436717001103 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 436717001104 putative translocon binding site; other site 436717001105 protein-rRNA interface [nucleotide binding]; other site 436717001106 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 436717001107 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The...; Region: 30S_S3_KH; cd02412 436717001108 G-X-X-G motif; other site 436717001109 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 436717001110 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 436717001111 23S rRNA interface [nucleotide binding]; other site 436717001112 5S rRNA interface [nucleotide binding]; other site 436717001113 putative antibiotic binding site [chemical binding]; other site 436717001114 L25 interface [polypeptide binding]; other site 436717001115 L27 interface [polypeptide binding]; other site 436717001116 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where...; Region: Ribosomal_L29_HIP; cd00427 436717001117 23S rRNA interface [nucleotide binding]; other site 436717001118 putative translocon interaction site; other site 436717001119 signal recognition particle (SRP54) interaction site; other site 436717001120 L23 interface [polypeptide binding]; other site 436717001121 trigger factor interaction site; other site 436717001122 Ribosomal protein S17; Region: Ribosomal_S17; cl00351 436717001123 Ribosomal protein L14p/L23e; Region: Ribosomal_L14; cl00328 436717001124 KOW motif; Region: KOW; cl00354 436717001125 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 436717001126 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 436717001127 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 436717001128 Ribosomal protein S14p/S29e; Region: Ribosomal_S14; cl00355 436717001129 Ribosomal protein S8; Region: Ribosomal_S8; cl00330 436717001130 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 436717001131 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 436717001132 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 436717001133 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 436717001134 5S rRNA interface [nucleotide binding]; other site 436717001135 23S rRNA interface [nucleotide binding]; other site 436717001136 L5 interface [polypeptide binding]; other site 436717001137 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 436717001138 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 436717001139 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 436717001140 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins...; Region: Ribosomal_L30; cd01658 436717001141 23S rRNA binding site [nucleotide binding]; other site 436717001142 Ribosomal protein L18e/L15; Region: Ribosomal_L18e; cl12022 436717001143 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 436717001144 SecY translocase; Region: SecY; pfam00344 436717001145 Ribosomal protein L36; Region: Ribosomal_L36; cl00380 436717001146 Ribosomal protein S13/S18; Region: Ribosomal_S13; cl00331 436717001147 Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]; Region: RpsM; COG0099 436717001148 Ribosomal protein S11; Region: Ribosomal_S11; cl00332 436717001149 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 436717001150 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 436717001151 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 436717001152 RNA binding surface [nucleotide binding]; other site 436717001153 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 436717001154 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 436717001155 alphaNTD homodimer interface [polypeptide binding]; other site 436717001156 alphaNTD - beta interaction site [polypeptide binding]; other site 436717001157 alphaNTD - beta' interaction site [polypeptide binding]; other site 436717001158 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; cl11613 436717001159 Ribosomal protein L17; Region: Ribosomal_L17; cl00356 436717001160 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 436717001161 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 436717001162 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 436717001163 active site 436717001164 Flavinator of succinate dehydrogenase; Region: Sdh5; cl01110 436717001165 Rhomboid family; Region: Rhomboid; cl11446 436717001166 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110 436717001167 Probable metal-binding protein (DUF2387); Region: DUF2387; cl01410 436717001168 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 436717001169 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 436717001170 active site 436717001171 Zn binding site [ion binding]; other site 436717001172 ribonuclease R; Region: RNase_R; TIGR02063 436717001173 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain...; Region: S1_like; cl09927 436717001174 RNB domain; Region: RNB; pfam00773 436717001175 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase play an...; Region: S1_RNase_R; cd04471 436717001176 RNA binding site [nucleotide binding]; other site 436717001177 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 436717001178 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 436717001179 Nitroreductase-like family 4. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_4; cd02140 436717001180 dimer interface [polypeptide binding]; other site 436717001181 FMN binding site [chemical binding]; other site 436717001182 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 436717001183 ribonuclease BN/unknown domain fusion protein; Reviewed; Region: rbn; PRK04214 436717001184 Ribonuclease BN-like family; Region: Ribonuclease_BN; cl07918 436717001185 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 436717001186 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 436717001187 Protein of unknown function (DUF3108); Region: DUF3108; pfam11306 436717001188 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 436717001189 Gram-negative bacterial tonB protein; Region: TonB; cl10048 436717001190 Uncharacterized protein family UPF0054; Region: UPF0054; cl00402 436717001191 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 436717001192 PhoH-like protein; Region: PhoH; cl12134 436717001193 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325 436717001194 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 436717001195 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 436717001196 FeS/SAM binding site; other site 436717001197 TRAM domain; Region: TRAM; cl01282 436717001198 lytic murein transglycosylase; Provisional; Region: PRK11619 436717001199 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 436717001200 N-acetyl-D-glucosamine binding site [chemical binding]; other site 436717001201 catalytic residue [active] 436717001202 Ribonuclease T2 (RNase T2) is a widespread family of secreted RNases found in every organism examined thus far. This family includes RNase Rh, RNase MC1, RNase LE, and self-incompatibility RNases (S-RNases). Plant T2 RNases are expressed during leaf...; Region: RNase_T2_prok; cd01062 436717001203 B1 nucleotide binding pocket [chemical binding]; other site 436717001204 B2 nucleotide binding pocket [chemical binding]; other site 436717001205 CAS motifs; other site 436717001206 Active site [active] 436717001207 malate dehydrogenase; Provisional; Region: PRK05442 436717001208 Chloroplast-like malate dehydrogenases; Region: MDH_choloroplast_like; cd01338 436717001209 NAD(P) binding site [chemical binding]; other site 436717001210 dimer interface [polypeptide binding]; other site 436717001211 malate binding site [chemical binding]; other site 436717001212 Protein of unknown function (DUF2789); Region: DUF2789; pfam10982 436717001213 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; cl01206 436717001214 Protein of unknown function (DUF519); Region: DUF519; cl04492 436717001215 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 436717001216 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 436717001217 Glutathione-dependent formaldehyde-activating enzyme; Region: GFA; cl01553 436717001218 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 436717001219 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 436717001220 active site 436717001221 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 436717001222 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 436717001223 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 436717001224 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 436717001225 Protein of unknown function (DUF1446); Region: DUF1446; pfam07287 436717001226 Trans-2-enoyl-CoA reductase (TER) and 2,4-dienoyl-CoA reductase (DECR), atypical (a) SDR; Region: TER_DECR_SDR_a; cd05369 436717001227 NAD(P) binding site [chemical binding]; other site 436717001228 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 436717001229 substrate binding site [chemical binding]; other site 436717001230 homotetramer interface [polypeptide binding]; other site 436717001231 active site 436717001232 homodimer interface [polypeptide binding]; other site 436717001233 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 436717001234 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl00513 436717001235 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl00513 436717001236 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 436717001237 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 436717001238 active site 436717001239 enoyl-CoA hydratase; Provisional; Region: PRK05995 436717001240 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 436717001241 substrate binding site [chemical binding]; other site 436717001242 oxyanion hole (OAH) forming residues; other site 436717001243 trimer interface [polypeptide binding]; other site 436717001244 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 436717001245 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 436717001246 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 436717001247 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 436717001248 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase...; Region: biotinyl_domain; cd06850 436717001249 carboxyltransferase (CT) interaction site; other site 436717001250 biotinylation site [posttranslational modification]; other site 436717001251 Roadblock/LC7 domain; Region: Robl_LC7; cl00886 436717001252 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 436717001253 G1 box; other site 436717001254 GTP/Mg2+ binding site [chemical binding]; other site 436717001255 G2 box; other site 436717001256 Switch I region; other site 436717001257 G3 box; other site 436717001258 Switch II region; other site 436717001259 G4 box; other site 436717001260 G5 box; other site 436717001261 Stringent starvation protein B; Region: SspB; cl01120 436717001262 stringent starvation protein A; Provisional; Region: sspA; PRK09481 436717001263 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 436717001264 GST_N family, Stringent starvation protein A (SspA) subfamily; SspA is a RNA polymerase (RNAP)-associated protein required for the lytic development of phage P1 and for stationary phase-induced acid tolerance of E. coli. It is implicated in survival...; Region: GST_C_SspA; cd03186 436717001265 dimer interface [polypeptide binding]; other site 436717001266 N-terminal domain interface [polypeptide binding]; other site 436717001267 Ribosomal protein S9/S16; Region: Ribosomal_S9; cl00334 436717001268 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 436717001269 23S rRNA interface [nucleotide binding]; other site 436717001270 L3 interface [polypeptide binding]; other site 436717001271 Pyridoxal phosphate biosynthetic protein PdxA; Region: PdxA; cl00873 436717001272 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 436717001273 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 436717001274 diadenosine tetraphosphatase; Reviewed; Region: apaH; PRK00166 436717001275 Escherichia coli ApaH and related proteins, metallophosphatase domain; Region: MPP_ApaH; cd07422 436717001276 active site 436717001277 metal binding site [ion binding]; metal-binding site 436717001278 Uncharacterized protein conserved in bacteria (DUF2147); Region: DUF2147; cl01951 436717001279 LrgB-like family; Region: LrgB; cl00596 436717001280 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 436717001281 HflX subfamily. A distinct conserved domain with a glycine-rich segment N-terminal of the GTPase domain characterizes the HflX subfamily. The E. coli HflX has been implicated in the control of the lambda cII repressor proteolysis, but the actual...; Region: HflX; cd01878 436717001282 G1 box; other site 436717001283 GTP/Mg2+ binding site [chemical binding]; other site 436717001284 Switch I region; other site 436717001285 G2 box; other site 436717001286 G3 box; other site 436717001287 Switch II region; other site 436717001288 G4 box; other site 436717001289 G5 box; other site 436717001290 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 436717001291 putative acyl-acceptor binding pocket; other site 436717001292 Putative catalytic domain, repeat 1, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_1; cd09111 436717001293 putative active site [active] 436717001294 catalytic site [active] 436717001295 Putative catalytic domain, repeat 2, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_2; cd09113 436717001296 putative active site [active] 436717001297 catalytic site [active] 436717001298 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 436717001299 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 436717001300 putative active site [active] 436717001301 putative metal binding site [ion binding]; other site 436717001302 putative outer membrane lipoprotein; Provisional; Region: PRK09967 436717001303 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 436717001304 ligand binding site [chemical binding]; other site 436717001305 putative inner membrane diguanylate cyclase; Provisional; Region: PRK09966 436717001306 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 436717001307 metal binding site [ion binding]; metal-binding site 436717001308 active site 436717001309 I-site; other site 436717001310 dihydrolipoamide dehydrogenase; Validated; Region: PRK06292 436717001311 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 436717001312 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 436717001313 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr (; Region: PTPc; cl00053 436717001314 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 436717001315 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 436717001316 thioredoxin 2; Provisional; Region: PRK10996 436717001317 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 436717001318 catalytic residues [active] 436717001319 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain...; Region: BFIT_BACH; cd03442 436717001320 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 436717001321 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 436717001322 CoenzymeA binding site [chemical binding]; other site 436717001323 subunit interaction site [polypeptide binding]; other site 436717001324 PHB binding site; other site 436717001325 Protein of unknown function (DUF520); Region: DUF520; cl00723 436717001326 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 436717001327 active site residue [active] 436717001328 bifunctional tRNA (mnm(5)s(2)U34)-methyltransferase/FAD-dependent cmnm(5)s(2)U34 oxidoreductase; Reviewed; Region: mnmC; PRK01747 436717001329 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 436717001330 Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl14881 436717001331 YCII-related domain; Region: YCII; cl00999 436717001332 Intracellular septation protein A; Region: IspA; cl01098 436717001333 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 436717001334 DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481 436717001335 Bestrophin, RFP-TM, chloride channel; Region: Bestrophin; cl01544 436717001336 hypothetical protein; Reviewed; Region: PRK00024 436717001337 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 436717001338 MPN+ (JAMM) motif; other site 436717001339 Zinc-binding site [ion binding]; other site 436717001340 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 436717001341 Flavoprotein; Region: Flavoprotein; cl08021 436717001342 DNA / pantothenate metabolism flavoprotein; Region: DFP; cl04410 436717001343 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 436717001344 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 436717001345 Protein export membrane protein; Region: SecD_SecF; cl14618 436717001346 EnvZ/OmpR regulon moderator; Provisional; Region: PRK10629 436717001347 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 436717001348 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 436717001349 Protein export membrane protein; Region: SecD_SecF; cl14618 436717001350 Preprotein translocase subunit; Region: YajC; cl00806 436717001351 Queuine tRNA-ribosyltransferase; Region: TGT; cl00409 436717001352 LemA family; Region: LemA; cl00742 436717001353 Queuosine biosynthesis protein; Region: Queuosine_synth; cl00523 436717001354 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 436717001355 Protein of unknown function (DUF2939); Region: DUF2939; pfam11159 436717001356 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 436717001357 dimer interface [polypeptide binding]; other site 436717001358 phosphorylation site [posttranslational modification] 436717001359 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 436717001360 ATP binding site [chemical binding]; other site 436717001361 Mg2+ binding site [ion binding]; other site 436717001362 G-X-G motif; other site 436717001363 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Reviewed; Region: PRK11072 436717001364 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 436717001365 metal binding triad; other site 436717001366 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 436717001367 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 436717001368 metal binding triad; other site 436717001369 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and alpha-...; Region: BCAT_beta_family; cd01557 436717001370 homodimer interface [polypeptide binding]; other site 436717001371 substrate-cofactor binding pocket; other site 436717001372 Aminotransferase class IV; Region: Aminotran_4; pfam01063 436717001373 catalytic residue [active] 436717001374 Predicted nucleoside-diphosphate-sugar epimerase [Cell envelope biogenesis, outer membrane]; Region: COG3660 436717001375 Protein of unknown function (DUF1022); Region: DUF1022; pfam06258 436717001376 Polysaccharide deacetylase; Region: Polysacc_deac_1; cl12061 436717001377 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 436717001378 putative metal binding site [ion binding]; other site 436717001379 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 436717001380 sugar transferase, PEP-CTERM/EpsH1 system associated; Region: stp2; TIGR03088 436717001381 putative ADP-binding pocket [chemical binding]; other site 436717001382 Glycosyltransferase family 25 [lipooligosaccharide (LOS) biosynthesis protein] is a family of glycosyltransferases involved in LOS biosynthesis. The members include the beta(1,4) galactosyltransferases: Lgt2 of Moraxella catarrhalis, LgtB and LgtE of...; Region: Glyco_transf_25; cd06532 436717001383 Protein of unknown function (DUF3184); Region: DUF3184; pfam11380 436717001384 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 436717001385 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 436717001386 dimer interface [polypeptide binding]; other site 436717001387 anticodon binding site; other site 436717001388 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of the...; Region: AspRS_core; cd00777 436717001389 homodimer interface [polypeptide binding]; other site 436717001390 motif 1; other site 436717001391 active site 436717001392 motif 2; other site 436717001393 GAD domain; Region: GAD; pfam02938 436717001394 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 436717001395 active site 436717001396 motif 3; other site 436717001397 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 436717001398 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 436717001399 N-terminal plug; other site 436717001400 ligand-binding site [chemical binding]; other site 436717001401 Putative catalytic domain, repeat 1, of uncharacterized phospholipase D-like proteins; Region: PLDc_unchar2_1; cd09129 436717001402 putative active site [active] 436717001403 putative catalytic site [active] 436717001404 Putative catalytic domain, repeat 2, of uncharacterized phospholipase D-like proteins; Region: PLDc_unchar2_2; cd09130 436717001405 putative active site [active] 436717001406 putative catalytic site [active] 436717001407 Domain of unknown function (DUF3315); Region: DUF3315; cl02275 436717001408 Phosphate-starvation-inducible E; Region: PsiE; cl01264 436717001409 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 436717001410 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 436717001411 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 436717001412 active site 436717001413 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 436717001414 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 436717001415 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 436717001416 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 436717001417 active site 436717001418 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 436717001419 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 436717001420 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 436717001421 dimer interface [polypeptide binding]; other site 436717001422 phosphorylation site [posttranslational modification] 436717001423 adaptive-response sensory kinase; Validated; Region: PRK09303 436717001424 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 436717001425 ATP binding site [chemical binding]; other site 436717001426 Mg2+ binding site [ion binding]; other site 436717001427 G-X-G motif; other site 436717001428 DNA-binding transcriptional regulator BaeR; Provisional; Region: PRK10710 436717001429 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 436717001430 active site 436717001431 phosphorylation site [posttranslational modification] 436717001432 intermolecular recognition site; other site 436717001433 dimerization interface [polypeptide binding]; other site 436717001434 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 436717001435 DNA binding site [nucleotide binding] 436717001436 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 436717001437 Uncharacterized conserved protein [Function unknown]; Region: COG0397; cl00428 436717001438 Uncharacterized ACR, YdiU/UPF0061 family; Region: UPF0061; pfam02696 436717001439 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 436717001440 Di-iron ligands [ion binding]; other site 436717001441 META domain; Region: META; cl01245 436717001442 Glycerophosphodiester phosphodiesterase domain as found in prokaryota and eukaryota, and similar proteins; Region: GDPD; cd08556 436717001443 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 436717001444 active site 436717001445 catalytic site [active] 436717001446 metal binding site [ion binding]; metal-binding site 436717001447 Cobalamin adenosyltransferase; Region: Cob_adeno_trans; cl00920 436717001448 Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206 436717001449 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 436717001450 N-terminal plug; other site 436717001451 ligand-binding site [chemical binding]; other site 436717001452 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are monomeric...; Region: PRAI; cd00405 436717001453 active site 436717001454 tryptophan synthase, beta chain; Region: PLN02618 436717001455 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 436717001456 pyridoxal 5'-phosphate binding site [chemical binding]; other site 436717001457 catalytic residue [active] 436717001458 Domain of Unknown Function (DUF1543); Region: DUF1543; pfam07566 436717001459 Protein of unknown function (DUF2804); Region: DUF2804; pfam10974 436717001460 Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118 436717001461 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687 436717001462 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 436717001463 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 436717001464 tryptophan synthase; Region: PLN02591 436717001465 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are...; Region: Tryptophan_synthase_alpha; cd04724 436717001466 substrate binding site [chemical binding]; other site 436717001467 active site 436717001468 catalytic residues [active] 436717001469 heterodimer interface [polypeptide binding]; other site 436717001470 Acetyl-CoA carboxylase beta subunit [Lipid metabolism]; Region: AccD; COG0777 436717001471 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl00513 436717001472 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 436717001473 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 436717001474 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 436717001475 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr (; Region: PTPc; cl00053 436717001476 active site 436717001477 catalytic residues [active] 436717001478 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 436717001479 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 436717001480 Peroxiredoxin (PRX) family, 1-cys PRX subfamily; composed of PRXs containing only one conserved cysteine, which serves as the peroxidatic cysteine. They are homodimeric thiol-specific antioxidant (TSA) proteins that confer a protective role in cells by...; Region: PRX_1cys; cd03016 436717001481 dimer interface [polypeptide binding]; other site 436717001482 decamer (pentamer of dimers) interface [polypeptide binding]; other site 436717001483 catalytic triad [active] 436717001484 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 436717001485 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl14882 436717001486 SecA preprotein cross-linking domain; Region: SecA_PP_bind; pfam01043 436717001487 SEC-C motif; Region: SEC-C; cl12132 436717001488 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 436717001489 metabolite-proton symporter; Region: 2A0106; TIGR00883 436717001490 putative substrate translocation pore; other site 436717001491 Haemolysin-III related; Region: HlyIII; cl03831 436717001492 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 436717001493 S-adenosylmethionine binding site [chemical binding]; other site 436717001494 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 436717001495 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 436717001496 Coenzyme A binding pocket [chemical binding]; other site 436717001497 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667 436717001498 Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208 436717001499 active site 436717001500 nucleophile elbow; other site 436717001501 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 436717001502 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 436717001503 substrate binding site [chemical binding]; other site 436717001504 oxyanion hole (OAH) forming residues; other site 436717001505 trimer interface [polypeptide binding]; other site 436717001506 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 436717001507 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 436717001508 acetyl-CoA acetyltransferase; Validated; Region: PRK08242 436717001509 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 436717001510 dimer interface [polypeptide binding]; other site 436717001511 active site 436717001512 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 436717001513 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 436717001514 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 436717001515 CoA-transferase family III; Region: CoA_transf_3; cl00778 436717001516 Carbohydrate-selective porin [Cell envelope biogenesis, outer membrane]; Region: OprB; COG3659 436717001517 Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966 436717001518 membrane-bound PQQ-dependent dehydrogenase, glucose/quinate/shikimate family; Region: PQQ_membr_DH; TIGR03074 436717001519 Dehydrogenases with pyrrolo-quinoline quinone (PQQ) as cofactor, like ethanol, methanol, and membrane bound glucose dehydrogenases. The alignment model contains an 8-bladed beta-propeller; Region: PQQ_DH; cd00216 436717001520 Trp docking motif; other site 436717001521 active site 436717001522 Dehydrogenases with pyrrolo-quinoline quinone (PQQ) as cofactor, like ethanol, methanol, and membrane bound glucose dehydrogenases. The alignment model contains an 8-bladed beta-propeller; Region: PQQ_DH; cl11493 436717001523 Trp docking motif; other site 436717001524 active site 436717001525 'Velcro' closure; other site 436717001526 Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155 436717001527 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 436717001528 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 436717001529 Bacterial protein of unknown function (DUF934); Region: DUF934; cl01526 436717001530 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 436717001531 dimer interface [polypeptide binding]; other site 436717001532 acetyl-CoA acetyltransferase; Provisional; Region: PRK06954 436717001533 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 436717001534 dimer interface [polypeptide binding]; other site 436717001535 active site 436717001536 Tfp pilus assembly protein FimT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimT; COG4970 436717001537 Type II transport protein GspH; Region: GspH; pfam12019 436717001538 Protein of unknown function, DUF481; Region: DUF481; cl01213 436717001539 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 436717001540 ligand binding site [chemical binding]; other site 436717001541 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a...; Region: Hint; cl12032 436717001542 hypothetical protein; Reviewed; Region: PRK09588 436717001543 Transmembrane amino acid transporter protein; Region: Aa_trans; cl00524 436717001544 Amino acid permease; Region: AA_permease; pfam00324 436717001545 16S ribosomal RNA m2G1207 methyltransferase; Provisional; Region: rsmC; PRK09489 436717001546 Methyltransferase small domain N-terminal; Region: MTS_N; pfam08468 436717001547 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 436717001548 Sulfate transporter family; Region: Sulfate_transp; cl00967 436717001549 TypA (tyrosine phosphorylated protein A)/BipA subfamily. BipA is a protein belonging to the ribosome-binding family of GTPases and is widely distributed in bacteria and plants. BipA was originally described as a protein that is induced in Salmonella...; Region: TypA_BipA; cd01891 436717001550 GTP-binding protein TypA/BipA; Region: TypA_BipA; TIGR01394 436717001551 G1 box; other site 436717001552 putative GEF interaction site [polypeptide binding]; other site 436717001553 GTP/Mg2+ binding site [chemical binding]; other site 436717001554 Switch I region; other site 436717001555 G2 box; other site 436717001556 G3 box; other site 436717001557 Switch II region; other site 436717001558 G4 box; other site 436717001559 G5 box; other site 436717001560 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 436717001561 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a...; Region: BipA_TypA_C; cd03710 436717001562 Large-conductance mechanosensitive channel, MscL; Region: MscL; cl00860 436717001563 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 436717001564 putative active site pocket [active] 436717001565 dimerization interface [polypeptide binding]; other site 436717001566 putative catalytic residue [active] 436717001567 PPIC-type PPIASE domain; Region: Rotamase; cl08278 436717001568 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 436717001569 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 436717001570 DNA binding site [nucleotide binding] 436717001571 catalytic residue [active] 436717001572 H2TH interface [polypeptide binding]; other site 436717001573 putative catalytic residues [active] 436717001574 turnover-facilitating residue; other site 436717001575 intercalation triad [nucleotide binding]; other site 436717001576 8OG recognition residue [nucleotide binding]; other site 436717001577 putative reading head residues; other site 436717001578 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 436717001579 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 436717001580 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 436717001581 active site 436717001582 DNA binding site [nucleotide binding] 436717001583 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 436717001584 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 436717001585 N-terminal plug; other site 436717001586 ligand-binding site [chemical binding]; other site 436717001587 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 436717001588 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 436717001589 active site 436717001590 FMN binding site [chemical binding]; other site 436717001591 substrate binding site [chemical binding]; other site 436717001592 homotetramer interface [polypeptide binding]; other site 436717001593 catalytic residue [active] 436717001594 Membrane transport protein; Region: Mem_trans; cl09117 436717001595 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 436717001596 Sel1 repeat; Region: Sel1; cl02723 436717001597 protein disulfide isomerase II DsbC; Provisional; Region: PRK10877 436717001598 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide...; Region: DsbA_DsbC_DsbG; cd03020 436717001599 dimerization domain [polypeptide binding]; other site 436717001600 dimer interface [polypeptide binding]; other site 436717001601 catalytic residues [active] 436717001602 Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354 436717001603 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 436717001604 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_2; cd08895 436717001605 putative hydrophobic ligand binding site [chemical binding]; other site 436717001606 Protein of unknown function, DUF488; Region: DUF488; cl01246 436717001607 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 436717001608 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 436717001609 PhnA protein; Region: PhnA; pfam03831 436717001610 Domain of unknown function (DUF1508); Region: DUF1508; cl01356 436717001611 Domain of unknown function (DUF1508); Region: DUF1508; cl01356 436717001612 prolyl-tRNA synthetase; Provisional; Region: PRK09194 436717001613 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation...; Region: ProRS_core_prok; cd00779 436717001614 dimer interface [polypeptide binding]; other site 436717001615 motif 1; other site 436717001616 active site 436717001617 motif 2; other site 436717001618 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and single-...; Region: ProRS-INS; cd04334 436717001619 putative deacylase active site [active] 436717001620 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 436717001621 active site 436717001622 motif 3; other site 436717001623 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-...; Region: ProRS_anticodon_short; cd00861 436717001624 anticodon binding site; other site 436717001625 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 436717001626 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 436717001627 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 436717001628 E3 interaction surface; other site 436717001629 lipoyl attachment site [posttranslational modification]; other site 436717001630 Response regulator receiver domain; Region: Response_reg; pfam00072 436717001631 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 436717001632 active site 436717001633 phosphorylation site [posttranslational modification] 436717001634 intermolecular recognition site; other site 436717001635 dimerization interface [polypeptide binding]; other site 436717001636 Response regulator receiver domain; Region: Response_reg; pfam00072 436717001637 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 436717001638 active site 436717001639 phosphorylation site [posttranslational modification] 436717001640 intermolecular recognition site; other site 436717001641 dimerization interface [polypeptide binding]; other site 436717001642 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 436717001643 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 436717001644 Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses. These...; Region: TarH; cl00144 436717001645 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086 436717001646 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 436717001647 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086 436717001648 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 436717001649 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 436717001650 putative binding surface; other site 436717001651 active site 436717001652 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086 436717001653 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 436717001654 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 436717001655 ATP binding site [chemical binding]; other site 436717001656 Mg2+ binding site [ion binding]; other site 436717001657 G-X-G motif; other site 436717001658 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 436717001659 Response regulator receiver domain; Region: Response_reg; pfam00072 436717001660 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 436717001661 active site 436717001662 phosphorylation site [posttranslational modification] 436717001663 intermolecular recognition site; other site 436717001664 dimerization interface [polypeptide binding]; other site 436717001665 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009 436717001666 M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891 436717001667 metal binding site [ion binding]; metal-binding site 436717001668 dimer interface [polypeptide binding]; other site 436717001669 Entericidin EcnA/B family; Region: Entericidin; cl02322 436717001670 Domain of unknown function (DUF1853); Region: DUF1853; cl01545 436717001671 Protein of unknown function (DUF454); Region: DUF454; cl01063 436717001672 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 436717001673 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 436717001674 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 436717001675 putative active site [active] 436717001676 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 436717001677 Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; Region: CysJ; COG0369 436717001678 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 436717001679 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR_like1; cd06200 436717001680 FAD binding pocket [chemical binding]; other site 436717001681 FAD binding motif [chemical binding]; other site 436717001682 catalytic residues [active] 436717001683 NAD binding pocket [chemical binding]; other site 436717001684 phosphate binding motif [ion binding]; other site 436717001685 beta-alpha-beta structure motif; other site 436717001686 hypothetical membrane protein, TIGR01666; Region: YCCS 436717001687 FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805 436717001688 bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102 436717001689 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 436717001690 putative substrate translocation pore; other site 436717001691 Nitroreductase family. Members of this family utilize FMN as a cofactor and catalyze reduction of a variety of nitroaromatic compounds, including nitrofurans, nitrobenzens, nitrophenol, nitrobenzoate and quinones by using either NADH or NADPH as a...; Region: Nitroreductase; cd02136 436717001692 putative FMN binding site [chemical binding]; other site 436717001693 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 436717001694 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 436717001695 Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205 436717001696 active site 436717001697 nucleophile elbow; other site 436717001698 threonine dehydratase; Provisional; Region: PRK07334 436717001699 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 436717001700 tetramer interface [polypeptide binding]; other site 436717001701 pyridoxal 5'-phosphate binding site [chemical binding]; other site 436717001702 catalytic residue [active] 436717001703 C-terminal ACT domain of biodegradative (catabolic) threonine dehydratase II (ThrD-II) and other related ACT domains; Region: ACT_ThrD-II-like; cd04886 436717001704 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 436717001705 Protein of unknown function (DUF1176); Region: DUF1176; pfam06674 436717001706 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_1; cd03169 436717001707 conserved cys residue [active] 436717001708 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 436717001709 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 436717001710 GatB domain; Region: GatB_Yqey; cl11497 436717001711 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 436717001712 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl11426 436717001713 Glu-tRNAGln amidotransferase C subunit; Region: Glu-tRNAGln; cl00495 436717001714 rod shape-determining protein MreB; Provisional; Region: PRK13927 436717001715 Cell division protein FtsA; Region: FtsA; cl11496 436717001716 rod shape-determining protein MreC; Provisional; Region: PRK13922 436717001717 rod shape-determining protein MreC; Region: MreC; pfam04085 436717001718 rod shape-determining protein MreD; Region: MreD; cl01087 436717001719 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 436717001720 active site 436717001721 dimer interface [polypeptide binding]; other site 436717001722 ribonuclease G; Provisional; Region: PRK11712 436717001723 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 436717001724 homodimer interface [polypeptide binding]; other site 436717001725 oligonucleotide binding site [chemical binding]; other site 436717001726 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 436717001727 Condensation domain; Region: Condensation; cl09290 436717001728 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 436717001729 Active Sites [active] 436717001730 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 436717001731 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 436717001732 Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; cl09488 436717001733 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 436717001734 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 436717001735 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 436717001736 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 436717001737 potential frameshift: common BLAST hit: gi|184159340|ref|YP_001847679.1| Fatty acid desaturase 436717001738 PaaX-like protein C-terminal domain; Region: PaaX_C; pfam08223 436717001739 Bacitracin resistance protein BacA; Region: BacA; cl00858 436717001740 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 436717001741 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 436717001742 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 436717001743 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 436717001744 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 436717001745 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 436717001746 NAD(P) binding site [chemical binding]; other site 436717001747 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 436717001748 conserved cys residue [active] 436717001749 Protein of unknown function (DUF2805); Region: DUF2805; cl11923 436717001750 Transmembrane amino acid transporter protein; Region: Aa_trans; cl00524 436717001751 probable AcnD-accessory protein PrpF; Region: prpF; TIGR02334 436717001752 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 436717001753 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 436717001754 substrate binding pocket [chemical binding]; other site 436717001755 chain length determination region; other site 436717001756 substrate-Mg2+ binding site; other site 436717001757 catalytic residues [active] 436717001758 aspartate-rich region 1; other site 436717001759 active site lid residues [active] 436717001760 aspartate-rich region 2; other site 436717001761 Protein of unknown function (DUF419); Region: DUF419; cl09948 436717001762 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 436717001763 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 436717001764 NfeD-like C-terminal, partner-binding; Region: NfeD; cl00686 436717001765 hypothetical protein; Provisional; Region: PRK10279 436717001766 Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205 436717001767 nucleophile elbow; other site 436717001768 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown ABO13168; Region: LPLAT_ABO13168-like; cd07988 436717001769 putative acyl-acceptor binding pocket; other site 436717001770 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl11420 436717001771 Porin subfamily; Region: Porin_2; pfam02530 436717001772 putative metal dependent hydrolase; Provisional; Region: PRK11598 436717001773 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 436717001774 Sulfatase; Region: Sulfatase; cl10460 436717001775 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 436717001776 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 436717001777 active site 436717001778 phosphorylation site [posttranslational modification] 436717001779 intermolecular recognition site; other site 436717001780 dimerization interface [polypeptide binding]; other site 436717001781 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 436717001782 DNA binding site [nucleotide binding] 436717001783 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 436717001784 dimer interface [polypeptide binding]; other site 436717001785 phosphorylation site [posttranslational modification] 436717001786 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 436717001787 ATP binding site [chemical binding]; other site 436717001788 Mg2+ binding site [ion binding]; other site 436717001789 G-X-G motif; other site 436717001790 PAP2_like_6 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which mainly contains bacterial proteins, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_6; cd03396 436717001791 active site 436717001792 Ammonium Transporter Family; Region: Ammonium_transp; cl03012 436717001793 Transcriptional regulator [Transcription]; Region: LysR; COG0583 436717001794 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 436717001795 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 436717001796 dimerization interface [polypeptide binding]; other site 436717001797 Membrane transport protein; Region: Mem_trans; cl09117 436717001798 Protein of unknown function DUF262; Region: DUF262; cl14890 436717001799 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 436717001800 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 436717001801 HIGH motif; other site 436717001802 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 436717001803 active site 436717001804 KMSKS motif; other site 436717001805 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 436717001806 tRNA binding surface [nucleotide binding]; other site 436717001807 anticodon binding site; other site 436717001808 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 436717001809 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 436717001810 short chain dehydrogenase; Provisional; Region: PRK06181 436717001811 NAD(P) binding site [chemical binding]; other site 436717001812 active site 436717001813 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 436717001814 Domain of unknown function (DUF74); Region: DUF74; cl00426 436717001815 Domain of unknown function (DUF74); Region: DUF74; cl00426 436717001816 NodT family; Region: outer_NodT; TIGR01845 436717001817 Outer membrane efflux protein; Region: OEP; pfam02321 436717001818 Outer membrane efflux protein; Region: OEP; pfam02321 436717001819 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 436717001820 Protein export membrane protein; Region: SecD_SecF; cl14618 436717001821 multidrug efflux system transporter AcrA; Provisional; Region: PRK15030 436717001822 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 436717001823 active site 436717001824 Site-specific recombinase [DNA replication, recombination, and repair]; Region: COG4389 436717001825 Site-specific recombinase; Region: SpecificRecomb; pfam10136 436717001826 octaprenyl diphosphate synthase; Provisional; Region: PRK10888 436717001827 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 436717001828 substrate binding pocket [chemical binding]; other site 436717001829 chain length determination region; other site 436717001830 substrate-Mg2+ binding site; other site 436717001831 catalytic residues [active] 436717001832 aspartate-rich region 1; other site 436717001833 active site lid residues [active] 436717001834 aspartate-rich region 2; other site 436717001835 Ribosomal prokaryotic L21 protein; Region: Ribosomal_L21p; cl00382 436717001836 Ribosomal L27 protein; Region: Ribosomal_L27; cl00359 436717001837 lipoprotein chaperone; Reviewed; Region: lolA; PRK00031 436717001838 Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl01065 436717001839 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 436717001840 seryl-tRNA synthetase; Provisional; Region: PRK05431 436717001841 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 436717001842 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 436717001843 dimer interface [polypeptide binding]; other site 436717001844 active site 436717001845 motif 1; other site 436717001846 motif 2; other site 436717001847 motif 3; other site 436717001848 siroheme synthase; Provisional; Region: cysG; PRK10637 436717001849 precorrin-2 dehydrogenase; Validated; Region: PRK06719 436717001850 Sirohaem synthase dimerisation region; Region: CysG_dimeriser; pfam10414 436717001851 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; cl00304 436717001852 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 436717001853 JmjC domain; Region: JmjC; pfam02373 436717001854 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 436717001855 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 436717001856 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 436717001857 Transmembrane amino acid transporter protein; Region: Aa_trans; cl00524 436717001858 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 436717001859 Iron-containing alcohol dehydrogenases-like; Region: Fe-ADH5; cd08189 436717001860 putative active site [active] 436717001861 metal binding site [ion binding]; metal-binding site 436717001862 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 436717001863 Protein of unknown function (DUF493); Region: DUF493; cl01102 436717001864 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 436717001865 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 436717001866 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 436717001867 Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546 436717001868 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 436717001869 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 436717001870 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171 436717001871 DNA binding residues [nucleotide binding] 436717001872 Uncharacterised protein family (UPF0149); Region: UPF0149; cl01173 436717001873 Predicted sulfurtransferase [General function prediction only]; Region: COG1054 436717001874 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 436717001875 active site residue [active] 436717001876 Protein of unknown function (DUF1289); Region: DUF1289; cl01304 436717001877 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 436717001878 dimer interface [polypeptide binding]; other site 436717001879 Citrate synthase; Region: Citrate_synt; pfam00285 436717001880 active site 436717001881 citrylCoA binding site [chemical binding]; other site 436717001882 NADH binding [chemical binding]; other site 436717001883 cationic pore residues; other site 436717001884 oxalacetate/citrate binding site [chemical binding]; other site 436717001885 coenzyme A binding site [chemical binding]; other site 436717001886 catalytic triad [active] 436717001887 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499 436717001888 Iron-sulfur protein interface; other site 436717001889 proximal quinone binding site [chemical binding]; other site 436717001890 SdhD (CybS) interface [polypeptide binding]; other site 436717001891 proximal heme binding site [chemical binding]; other site 436717001892 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. E. coli SQR, a member of this subfamily, reduces the...; Region: SQR_TypeC_SdhD; cd03494 436717001893 SdhC subunit interface [polypeptide binding]; other site 436717001894 proximal heme binding site [chemical binding]; other site 436717001895 cardiolipin binding site; other site 436717001896 Iron-sulfur protein interface; other site 436717001897 proximal quinone binding site [chemical binding]; other site 436717001898 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07057 436717001899 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 436717001900 domain; Region: Succ_DH_flav_C; pfam02910 436717001901 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 436717001902 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 436717001903 TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of 2-oxoglutarate to succinyl-CoA and carbon dioxide, a key reaction of...; Region: TPP_E1_OGDC_like; cd02016 436717001904 TPP-binding site [chemical binding]; other site 436717001905 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 436717001906 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 436717001907 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 436717001908 E3 interaction surface; other site 436717001909 lipoyl attachment site [posttranslational modification]; other site 436717001910 e3 binding domain; Region: E3_binding; pfam02817 436717001911 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008 436717001912 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06467 436717001913 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 436717001914 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 436717001915 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 436717001916 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 436717001917 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 436717001918 CoA-ligase; Region: Ligase_CoA; pfam00549 436717001919 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 436717001920 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 436717001921 CoA-ligase; Region: Ligase_CoA; pfam00549 436717001922 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 436717001923 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 436717001924 active site 436717001925 HIGH motif; other site 436717001926 dimer interface [polypeptide binding]; other site 436717001927 KMSKS motif; other site 436717001928 Protein of unknown function (DUF808); Region: DUF808; cl01002 436717001929 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; cl00988 436717001930 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 436717001931 potential frameshift: common BLAST hit: gi|213157636|ref|YP_002320434.1| biofilm-associated protein 436717001932 type 2 lantibiotic biosynthesis protein LanM; Region: lanti_2_LanM; TIGR03897 436717001933 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 436717001934 putative active site [active] 436717001935 putative metal binding site [ion binding]; other site 436717001936 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 436717001937 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families...; Region: ZnMc; cl00064 436717001938 active site 436717001939 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 436717001940 DNA binding site [nucleotide binding] 436717001941 active site 436717001942 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 436717001943 Ligand Binding Site [chemical binding]; other site 436717001944 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 436717001945 trimer interface [polypeptide binding]; other site 436717001946 active site 436717001947 substrate binding site [chemical binding]; other site 436717001948 CoA binding site [chemical binding]; other site 436717001949 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 436717001950 domain; Region: GreA_GreB_N; pfam03449 436717001951 C-term; Region: GreA_GreB; pfam01272 436717001952 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 436717001953 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 436717001954 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 436717001955 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 436717001956 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 436717001957 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 436717001958 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 436717001959 IMP binding site; other site 436717001960 dimer interface [polypeptide binding]; other site 436717001961 interdomain contacts; other site 436717001962 partial ornithine binding site; other site 436717001963 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 436717001964 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; pfam00988 436717001965 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 436717001966 catalytic site [active] 436717001967 subunit interface [polypeptide binding]; other site 436717001968 Domon-like domain of UDP-N-acetylenolpyruvoylglucosamine reductase; Region: DOMON_murB_like; cd09627 436717001969 putative heme binding site [chemical binding]; other site 436717001970 CRS1 / YhbY (CRM) domain; Region: CRS1_YhbY; cl00663 436717001971 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 436717001972 FtsH Extracellular; Region: FtsH_ext; pfam06480 436717001973 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 436717001974 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 436717001975 Walker A motif; other site 436717001976 ATP binding site [chemical binding]; other site 436717001977 Walker B motif; other site 436717001978 arginine finger; other site 436717001979 Peptidase family M41; Region: Peptidase_M41; pfam01434 436717001980 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 436717001981 dihydropteroate synthase; Region: DHPS; TIGR01496 436717001982 substrate binding pocket [chemical binding]; other site 436717001983 dimer interface [polypeptide binding]; other site 436717001984 inhibitor binding site; inhibition site 436717001985 PhoD-like phosphatase; Region: PhoD; pfam09423 436717001986 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 436717001987 putative active site [active] 436717001988 putative metal binding site [ion binding]; other site 436717001989 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 436717001990 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14192 436717001991 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 436717001992 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 436717001993 homodimer interface [polypeptide binding]; other site 436717001994 NADP binding site [chemical binding]; other site 436717001995 substrate binding site [chemical binding]; other site 436717001996 Predicted methyltransferase [General function prediction only]; Region: COG3897 436717001997 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 436717001998 alpha-ketoglutarate transporter; Provisional; Region: PRK10406 436717001999 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 436717002000 putative substrate translocation pore; other site 436717002001 glycerol kinase; Provisional; Region: glpK; PRK00047 436717002002 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 436717002003 FGGY family of carbohydrate kinases, C-terminal domain; Region: FGGY_C; pfam02782 436717002004 glycerol-3-phosphate dehydrogenase; Reviewed; Region: glpD; PRK12266 436717002005 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819 436717002006 Phosphoenolpyruvate carboxykinase; Region: PEPCK; pfam00821 436717002007 active site 436717002008 substrate-binding site [chemical binding]; other site 436717002009 metal-binding site [ion binding] 436717002010 GTP binding site [chemical binding]; other site 436717002011 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 436717002012 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 436717002013 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 436717002014 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 436717002015 active site 436717002016 metal binding site [ion binding]; metal-binding site 436717002017 Protein of unknown function (DUF3607); Region: DUF3607; pfam12245 436717002018 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; cl12108 436717002019 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; cl12108 436717002020 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts...; Region: cpn10; cd00320 436717002021 oligomerisation interface [polypeptide binding]; other site 436717002022 mobile loop; other site 436717002023 roof hairpin; other site 436717002024 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 436717002025 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 436717002026 ring oligomerisation interface [polypeptide binding]; other site 436717002027 ATP/Mg binding site [chemical binding]; other site 436717002028 stacking interactions; other site 436717002029 hinge regions; other site 436717002030 Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; cl00526 436717002031 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 436717002032 Glycerophosphodiester phosphodiesterase domain of Streptomycin coelicolor (GlpQ1) and similar proteins; Region: GDPD_ScGlpQ1_like; cd08602 436717002033 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 436717002034 putative active site [active] 436717002035 catalytic site [active] 436717002036 putative metal binding site [ion binding]; other site 436717002037 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 436717002038 Peptidase family M48; Region: Peptidase_M48; cl12018 436717002039 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 436717002040 N-acetyl-D-glucosamine binding site [chemical binding]; other site 436717002041 catalytic residue [active] 436717002042 tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696 436717002043 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This...; Region: Alpha_ANH_like_II; cd01993 436717002044 Ligand Binding Site [chemical binding]; other site 436717002045 SCP-2 sterol transfer family; Region: SCP2; cl01225 436717002046 membrane-bound lytic transglycosylase F; Provisional; Region: PRK10859 436717002047 membrane-bound lytic transglycosylase F; Provisional; Region: PRK10859 436717002048 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 436717002049 N-acetyl-D-glucosamine binding site [chemical binding]; other site 436717002050 catalytic residue [active] 436717002051 transcription elongation factor GreB; Reviewed; Region: greB; PRK01885 436717002052 domain; Region: GreA_GreB_N; pfam03449 436717002053 C-term; Region: GreA_GreB; pfam01272 436717002054 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 436717002055 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 436717002056 NAD(P) binding site [chemical binding]; other site 436717002057 active site 436717002058 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 436717002059 Transcriptional regulator [Transcription]; Region: LysR; COG0583 436717002060 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 436717002061 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 436717002062 putative effector binding pocket; other site 436717002063 putative dimerization interface [polypeptide binding]; other site 436717002064 enterobactin synthase subunit E; Provisional; Region: entE; PRK10946 436717002065 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 436717002066 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 436717002067 non-ribosomal peptide synthetase terminal domain of unknown function; Region: NRPS_term_dom; TIGR02353 436717002068 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 436717002069 putative trimer interface [polypeptide binding]; other site 436717002070 putative CoA binding site [chemical binding]; other site 436717002071 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 436717002072 putative CoA binding site [chemical binding]; other site 436717002073 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 436717002074 putative trimer interface [polypeptide binding]; other site 436717002075 putative CoA binding site [chemical binding]; other site 436717002076 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 436717002077 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 436717002078 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 436717002079 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687 436717002080 Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118 436717002081 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 436717002082 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 436717002083 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 436717002084 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 436717002085 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 436717002086 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 436717002087 FMN binding site [chemical binding]; other site 436717002088 active site 436717002089 substrate binding site [chemical binding]; other site 436717002090 catalytic residue [active] 436717002091 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 436717002092 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 436717002093 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 436717002094 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 436717002095 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 436717002096 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 436717002097 multidrug efflux system transporter AcrA; Provisional; Region: PRK15030 436717002098 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 436717002099 Protein export membrane protein; Region: SecD_SecF; cl14618 436717002100 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 436717002101 dimer interface [polypeptide binding]; other site 436717002102 FMN binding site [chemical binding]; other site 436717002103 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 436717002104 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 436717002105 NAD(P) binding site [chemical binding]; other site 436717002106 active site 436717002107 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 436717002108 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 436717002109 Glycerate kinase family; Region: Gly_kinase; cl00841 436717002110 oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701 436717002111 The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767 436717002112 putative molybdopterin cofactor binding site [chemical binding]; other site 436717002113 The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT)...; Region: MopB_CT_ydeP; cd02787 436717002114 putative molybdopterin cofactor binding site; other site 436717002115 FdhD/NarQ family; Region: FdhD-NarQ; cl00659 436717002116 erythronate-4-phosphate dehydrogenase; Validated; Region: PRK00257 436717002117 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 436717002118 Domain of unknown function (DUF3410); Region: DUF3410; pfam11890 436717002119 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 436717002120 lysyl-tRNA synthetase-like protein GenX; Region: genX; TIGR00462 436717002121 motif 1; other site 436717002122 dimer interface [polypeptide binding]; other site 436717002123 active site 436717002124 motif 2; other site 436717002125 motif 3; other site 436717002126 Tim44-like domain; Region: Tim44; cl09208 436717002127 DNA repair protein RadA; Provisional; Region: PRK11823 436717002128 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 436717002129 Walker A motif/ATP binding site; other site 436717002130 ATP binding site [chemical binding]; other site 436717002131 Walker B motif; other site 436717002132 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 436717002133 Transmembrane amino acid transporter protein; Region: Aa_trans; cl00524 436717002134 Amino acid permease; Region: AA_permease; pfam00324 436717002135 diaminopimelate decarboxylase; Region: lysA; TIGR01048 436717002136 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 436717002137 active site 436717002138 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 436717002139 substrate binding site [chemical binding]; other site 436717002140 catalytic residues [active] 436717002141 dimer interface [polypeptide binding]; other site 436717002142 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 436717002143 Diaminopimelate epimerase; Region: DAP_epimerase; cl14668 436717002144 Diaminopimelate epimerase; Region: DAP_epimerase; cl14668 436717002145 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 436717002146 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 436717002147 LysE type translocator; Region: LysE; cl00565 436717002148 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 436717002149 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 436717002150 DNA binding site [nucleotide binding] 436717002151 Int/Topo IB signature motif; other site 436717002152 active site 436717002153 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 436717002154 Ligand binding site [chemical binding]; other site 436717002155 electron transfer flavoprotein subunit alpha; Provisional; Region: PLN00022 436717002156 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 436717002157 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 436717002158 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 436717002159 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 436717002160 DNA gyrase subunit A; Validated; Region: PRK05560 436717002161 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in...; Region: TOP4c; cd00187 436717002162 CAP-like domain; other site 436717002163 Active site [active] 436717002164 primary dimer interface [polypeptide binding]; other site 436717002165 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 436717002166 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 436717002167 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 436717002168 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 436717002169 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 436717002170 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 436717002171 4-amino-4-deoxy-L-arabinose transferase; Provisional; Region: arnT; PRK13279 436717002172 GtrA-like protein; Region: GtrA; cl00971 436717002173 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 436717002174 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 436717002175 Ligand binding site [chemical binding]; other site 436717002176 Putative Catalytic site [active] 436717002177 DXD motif; other site 436717002178 YdjC-like protein; Region: YdjC; cl01344 436717002179 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 436717002180 ABC-2 type transporter; Region: ABC2_membrane; cl11417 436717002181 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 436717002182 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 436717002183 Outer membrane efflux protein; Region: OEP; pfam02321 436717002184 Outer membrane efflux protein; Region: OEP; pfam02321 436717002185 Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT). PSAT is active...; Region: PSAT_like; cd00611 436717002186 homodimer interface [polypeptide binding]; other site 436717002187 substrate-cofactor binding pocket; other site 436717002188 pyridoxal 5'-phosphate binding site [chemical binding]; other site 436717002189 catalytic residue [active] 436717002190 Uncharacterized BCR, YaiI/YqxD family COG1671; Region: DUF188; cl00727 436717002191 putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272 436717002192 EamA-like transporter family; Region: EamA; cl01037 436717002193 LolC/E family; Region: lolCE; TIGR02212 436717002194 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 436717002195 FtsX-like permease family; Region: FtsX; pfam02687 436717002196 lipoprotein releasing system, ATP-binding protein; Region: LolD_lipo_ex; TIGR02211 436717002197 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 436717002198 Walker A/P-loop; other site 436717002199 ATP binding site [chemical binding]; other site 436717002200 Q-loop/lid; other site 436717002201 ABC transporter signature motif; other site 436717002202 Walker B; other site 436717002203 D-loop; other site 436717002204 H-loop/switch region; other site 436717002205 DNA internalization-related competence protein ComEC/Rec2; Region: ComEC_Rec2; TIGR00361 436717002206 Competence protein; Region: Competence; cl00471 436717002207 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 436717002208 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 436717002209 putative acyl-acceptor binding pocket; other site 436717002210 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 436717002211 tandem repeat interface [polypeptide binding]; other site 436717002212 oligomer interface [polypeptide binding]; other site 436717002213 active site residues [active] 436717002214 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 436717002215 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 436717002216 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 436717002217 active site 436717002218 substrate binding site [chemical binding]; other site 436717002219 cosubstrate binding site; other site 436717002220 catalytic site [active] 436717002221 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 436717002222 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine...; Region: PurM; cd02196 436717002223 dimerization interface [polypeptide binding]; other site 436717002224 putative ATP binding site [chemical binding]; other site 436717002225 Domain of unknown function DUF20; Region: UPF0118; cl00465 436717002226 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 436717002227 Protein of unknown function (DUF3106); Region: DUF3106; pfam11304 436717002228 RNA polymerase factor sigma-70; Validated; Region: PRK09047 436717002229 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 436717002230 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171 436717002231 DNA binding residues [nucleotide binding] 436717002232 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 436717002233 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 436717002234 fructose-1,6-bisphosphatase family protein; Region: PLN02628 436717002235 Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1,7-...; Region: FBPase; cd00354 436717002236 AMP binding site [chemical binding]; other site 436717002237 metal binding site [ion binding]; metal-binding site 436717002238 active site 436717002239 peptidoglycan-associated outer membrane lipoprotein; Provisional; Region: PRK10802 436717002240 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 436717002241 ligand binding site [chemical binding]; other site 436717002242 translocation protein TolB; Provisional; Region: tolB; PRK04922 436717002243 TolB amino-terminal domain; Region: TolB_N; pfam04052 436717002244 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 436717002245 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 436717002246 Gram-negative bacterial tonB protein; Region: TonB; cl10048 436717002247 Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537 436717002248 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 436717002249 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 436717002250 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active...; Region: 4HBT; cd00586 436717002251 active site 436717002252 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like2; cd05667 436717002253 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 436717002254 metal binding site [ion binding]; metal-binding site 436717002255 putative dimer interface [polypeptide binding]; other site 436717002256 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 436717002257 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 436717002258 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 436717002259 Walker A motif; other site 436717002260 ATP binding site [chemical binding]; other site 436717002261 Walker B motif; other site 436717002262 arginine finger; other site 436717002263 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 436717002264 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 436717002265 RuvA N terminal domain; Region: RuvA_N; pfam01330 436717002266 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 436717002267 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01096 436717002268 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 436717002269 phosphoribosylformylglycinamidine synthase; Provisional; Region: PRK05297 436717002270 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP...; Region: PurL_repeat1; cd02203 436717002271 dimerization interface [polypeptide binding]; other site 436717002272 ATP binding site [chemical binding]; other site 436717002273 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP...; Region: PurL_repeat2; cd02204 436717002274 dimerization interface [polypeptide binding]; other site 436717002275 ATP binding site [chemical binding]; other site 436717002276 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 436717002277 putative active site [active] 436717002278 catalytic triad [active] 436717002279 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 436717002280 putative substrate translocation pore; other site 436717002281 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl01309 436717002282 enoyl-CoA hydratase; Provisional; Region: PRK06688 436717002283 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 436717002284 substrate binding site [chemical binding]; other site 436717002285 oxyanion hole (OAH) forming residues; other site 436717002286 trimer interface [polypeptide binding]; other site 436717002287 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 436717002288 active site 436717002289 nucleotide binding site [chemical binding]; other site 436717002290 HIGH motif; other site 436717002291 KMSKS motif; other site 436717002292 Putative lumazine-binding; Region: Lumazine_bd_2; pfam12893 436717002293 Bleomycin binding protein (BLMA) and similar proteins; BLMA confers bleomycin (Bm) resistance by directly binding to Bm; Region: BLMA_like; cd08349 436717002294 dimer interface [polypeptide binding]; other site 436717002295 ligand binding site [chemical binding]; other site 436717002296 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 436717002297 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by...; Region: PRX_BCP; cd03017 436717002298 catalytic triad [active] 436717002299 MJ0570-related uncharacterized domain; Region: MJ0570_dom; TIGR00290 436717002300 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This...; Region: Alpha_ANH_like_IV; cd01994 436717002301 Ligand Binding Site [chemical binding]; other site 436717002302 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 436717002303 Ligand Binding Site [chemical binding]; other site 436717002304 Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602 436717002305 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 436717002306 FeS/SAM binding site; other site 436717002307 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830 436717002308 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA...; Region: LbH_THP_succinylT; cd03350 436717002309 active site 436717002310 substrate binding site [chemical binding]; other site 436717002311 trimer interface [polypeptide binding]; other site 436717002312 CoA binding site [chemical binding]; other site 436717002313 transcriptional regulator CysB-like protein; Reviewed; Region: PRK12683 436717002314 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 436717002315 The C-terminal substrate domain of LysR-type transcriptional regulators CysB-like contains type 2 periplasmic binding fold; Region: PBP2_CysB_like; cd08413 436717002316 substrate binding site [chemical binding]; other site 436717002317 dimerization interface [polypeptide binding]; other site 436717002318 ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118 436717002319 Part of the ABC transporter complex cysAWTP involved in sulfate import. Responsible for energy coupling to the transport system. The complex is composed of two ATP-binding proteins (cysA), two transmembrane proteins (cysT and cysW), and a solute-...; Region: ABC_CysA_sulfate_importer; cd03296 436717002320 Walker A/P-loop; other site 436717002321 ATP binding site [chemical binding]; other site 436717002322 Q-loop/lid; other site 436717002323 ABC transporter signature motif; other site 436717002324 Walker B; other site 436717002325 D-loop; other site 436717002326 H-loop/switch region; other site 436717002327 TOBE-like domain; Region: TOBE_3; pfam12857 436717002328 sulfate transport protein; Provisional; Region: cysT; CHL00187 436717002329 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 436717002330 dimer interface [polypeptide binding]; other site 436717002331 conserved gate region; other site 436717002332 putative PBP binding loops; other site 436717002333 ABC-ATPase subunit interface; other site 436717002334 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 436717002335 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 436717002336 dimer interface [polypeptide binding]; other site 436717002337 conserved gate region; other site 436717002338 putative PBP binding loops; other site 436717002339 ABC-ATPase subunit interface; other site 436717002340 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 436717002341 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 436717002342 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 436717002343 Aminotransferase class IV; Region: Aminotran_4; pfam01063 436717002344 pyridoxal 5'-phosphate binding site [chemical binding]; other site 436717002345 catalytic residue [active] 436717002346 YceG-like family; Region: YceG; pfam02618 436717002347 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 436717002348 dimerization interface [polypeptide binding]; other site 436717002349 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting...; Region: TMPK; cd01672 436717002350 thymidylate kinase; Validated; Region: tmk; PRK00698 436717002351 TMP-binding site; other site 436717002352 ATP-binding site [chemical binding]; other site 436717002353 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 436717002354 CoenzymeA binding site [chemical binding]; other site 436717002355 subunit interaction site [polypeptide binding]; other site 436717002356 PHB binding site; other site 436717002357 L-aspartate oxidase; Provisional; Region: PRK09077 436717002358 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 436717002359 domain; Region: Succ_DH_flav_C; pfam02910 436717002360 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 436717002361 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic...; Region: Tryp_SPc; cl00149 436717002362 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind C-...; Region: PDZ_serine_protease; cd00987 436717002363 protein binding site [polypeptide binding]; other site 436717002364 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind C-...; Region: PDZ_serine_protease; cd00987 436717002365 protein binding site [polypeptide binding]; other site 436717002366 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active...; Region: 4HBT; cd00586 436717002367 active site 436717002368 GTP-binding protein LepA; Provisional; Region: PRK05433 436717002369 LepA subfamily. LepA belongs to the GTPase family of and exhibits significant homology to the translation factors EF-G and EF-Tu, indicating its possible involvement in translation and association with the ribosome. LepA is ubiquitous in bacteria and...; Region: LepA; cd01890 436717002370 G1 box; other site 436717002371 putative GEF interaction site [polypeptide binding]; other site 436717002372 GTP/Mg2+ binding site [chemical binding]; other site 436717002373 Switch I region; other site 436717002374 G2 box; other site 436717002375 G3 box; other site 436717002376 Switch II region; other site 436717002377 G4 box; other site 436717002378 G5 box; other site 436717002379 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-...; Region: lepA_II; cd03699 436717002380 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 436717002381 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 436717002382 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 436717002383 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 436717002384 Catalytic site [active] 436717002385 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 436717002386 ribonuclease III; Reviewed; Region: rnc; PRK00102 436717002387 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in post-...; Region: RIBOc; cd00593 436717002388 dimerization interface [polypeptide binding]; other site 436717002389 active site 436717002390 metal binding site [ion binding]; metal-binding site 436717002391 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase...; Region: DSRM; cd00048 436717002392 dsRNA binding site [nucleotide binding]; other site 436717002393 GTPase Era; Reviewed; Region: era; PRK00089 436717002394 Era subfamily. Era (E. coli Ras-like protein) is a multifunctional GTPase found in all bacteria except some eubacteria. It binds to the 16S ribosomal RNA (rRNA) of the 30S subunit and appears to play a role in the assembly of the 30S subunit...; Region: Era; cd04163 436717002395 G1 box; other site 436717002396 GTP/Mg2+ binding site [chemical binding]; other site 436717002397 Switch I region; other site 436717002398 G2 box; other site 436717002399 Switch II region; other site 436717002400 G3 box; other site 436717002401 G4 box; other site 436717002402 G5 box; other site 436717002403 K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains...; Region: KH-I; cl00098 436717002404 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 436717002405 Recombination protein O N terminal; Region: RecO_N; pfam11967 436717002406 Recombination protein O C terminal; Region: RecO_C; pfam02565 436717002407 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in the...; Region: PNPsynthase; cd00003 436717002408 active site 436717002409 hydrophilic channel; other site 436717002410 dimerization interface [polypeptide binding]; other site 436717002411 catalytic residues [active] 436717002412 active site lid [active] 436717002413 MiaE tRNA-modifying nonheme diiron monooxygenase, ferritin-like diiron-binding domain; Region: MiaE; cd07910 436717002414 active site 436717002415 dinuclear metal binding site [ion binding]; other site 436717002416 dimerization interface [polypeptide binding]; other site 436717002417 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 436717002418 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 436717002419 NAD(P) binding site [chemical binding]; other site 436717002420 active site 436717002421 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 436717002422 CoenzymeA binding site [chemical binding]; other site 436717002423 subunit interaction site [polypeptide binding]; other site 436717002424 PHB binding site; other site 436717002425 Glutathione-dependent formaldehyde-activating enzyme; Region: GFA; cl01553 436717002426 aspartate aminotransferase; Provisional; Region: PRK08361 436717002427 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 436717002428 pyridoxal 5'-phosphate binding site [chemical binding]; other site 436717002429 homodimer interface [polypeptide binding]; other site 436717002430 catalytic residue [active] 436717002431 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 436717002432 metal binding site [ion binding]; metal-binding site 436717002433 active site 436717002434 I-site; other site 436717002435 hypothetical protein; Region: PHA00684 436717002436 excinuclease ABC subunit B; Provisional; Region: PRK05298 436717002437 Myosin and Kinesin motor domain. These ATPases belong to the P-loop NTPase family and provide the driving force in myosin and kinesin mediated processes; Region: Motor_domain; cl00286 436717002438 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 436717002439 ATP-binding site [chemical binding]; other site 436717002440 ATP binding site [chemical binding]; other site 436717002441 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 436717002442 nucleotide binding region [chemical binding]; other site 436717002443 ATP-binding site [chemical binding]; other site 436717002444 Ultra-violet resistance protein B; Region: UvrB; pfam12344 436717002445 UvrB/uvrC motif; Region: UVR; pfam02151 436717002446 Lipocalin / cytosolic fatty-acid binding protein family; Region: Lipocalin; cl01150 436717002447 Predicted permeases [General function prediction only]; Region: RarD; COG2962 436717002448 glyceraldehyde-3-phosphate dehydrogenase; Reviewed; Region: PRK08289 436717002449 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 436717002450 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 436717002451 GTPase CgtA; Reviewed; Region: obgE; PRK12298 436717002452 GTP1/OBG; Region: GTP1_OBG; pfam01018 436717002453 Obg subfamily. The Obg nucleotide binding protein subfamily has been implicated in stress response, chromosome partitioning, replication initiation, mycelium development, and sporulation. Obg proteins are among a large group of GTP binding proteins...; Region: Obg; cd01898 436717002454 G1 box; other site 436717002455 GTP/Mg2+ binding site [chemical binding]; other site 436717002456 Switch I region; other site 436717002457 G2 box; other site 436717002458 G3 box; other site 436717002459 Switch II region; other site 436717002460 G4 box; other site 436717002461 G5 box; other site 436717002462 gamma-glutamyl kinase; Provisional; Region: PRK05429 436717002463 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 436717002464 nucleotide binding site [chemical binding]; other site 436717002465 homotetrameric interface [polypeptide binding]; other site 436717002466 putative phosphate binding site [ion binding]; other site 436717002467 putative allosteric binding site; other site 436717002468 PUA domain; Region: PUA; cl00607 436717002469 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 436717002470 Protein of unknown function (DUF1615); Region: DUF1615; pfam07759 436717002471 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 436717002472 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and...; Region: DUS_like_FMN; cd02801 436717002473 FMN binding site [chemical binding]; other site 436717002474 active site 436717002475 catalytic residues [active] 436717002476 substrate binding site [chemical binding]; other site 436717002477 Nitronate monooxygenase; Region: NMO; pfam03060 436717002478 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin...; Region: NPD_like; cd04730 436717002479 FMN binding site [chemical binding]; other site 436717002480 substrate binding site [chemical binding]; other site 436717002481 putative catalytic residue [active] 436717002482 Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_1; cd02432 436717002483 Putative Zn-dependent protease, contains TPR repeats [General function prediction only]; Region: COG4783 436717002484 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 436717002485 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 436717002486 DXD motif; other site 436717002487 deoxyribodipyrimidine photolyase; Provisional; Region: PRK10674 436717002488 DNA photolyase; Region: DNA_photolyase; pfam00875 436717002489 FAD binding domain of DNA photolyase; Region: FAD_binding_7; pfam03441 436717002490 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587 436717002491 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 436717002492 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 436717002493 Beta-lactamase; Region: Beta-lactamase; cl01009 436717002494 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 436717002495 Predicted protease with the C-terminal PDZ domain [General function prediction only]; Region: COG3975 436717002496 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 436717002497 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 436717002498 protein binding site [polypeptide binding]; other site 436717002499 Monomeric isocitrate dehydrogenase [Energy production and conversion]; Region: Icd; COG2838 436717002500 Monomeric isocitrate dehydrogenase; Region: IDH; pfam03971 436717002501 PseudoU_synth_RluE: Pseudouridine synthase, Escherichia coli RluE. This group is comprised of bacterial proteins similar to E. coli RluE. Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-...; Region: PseudoU_synth_RluE; cd02566 436717002502 probable active site [active] 436717002503 isocitrate dehydrogenase; Validated; Region: PRK07362 436717002504 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 436717002505 Major Facilitator Superfamily; Region: MFS_1; pfam07690 436717002506 Protein of unknown function (DUF1228); Region: DUF1228; pfam06779 436717002507 Transcriptional regulator [Transcription]; Region: LysR; COG0583 436717002508 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 436717002509 The C-terminal substrate binding domain of LysR-type transcriptional regulators, YofA and SoxR, contains the type 2 periplasmic binding fold; Region: PBP2_YofA_SoxR_like; cd08442 436717002510 putative dimerization interface [polypeptide binding]; other site 436717002511 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 436717002512 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 436717002513 Diaminopimelate epimerase; Region: DAP_epimerase; cl14668 436717002514 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 436717002515 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 436717002516 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 436717002517 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 436717002518 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 436717002519 Protein of unknown function (DUF3144); Region: DUF3144; pfam11342 436717002520 Uncharacterized conserved protein [Function unknown]; Region: COG3025 436717002521 Uncharacterized subgroup of the CYTH-like superfamily having an associated CHAD domain; Region: CYTH-like_Pase_CHAD; cd07756 436717002522 putative active site [active] 436717002523 putative metal binding residues [ion binding]; other site 436717002524 signature motif; other site 436717002525 putative triphosphate binding site [ion binding]; other site 436717002526 CHAD domain; Region: CHAD; cl10506 436717002527 Protein of unknown function (DUF962); Region: DUF962; cl01879 436717002528 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5- (beta-...; Region: TMP_TenI; cd00564 436717002529 thiamine phosphate binding site [chemical binding]; other site 436717002530 active site 436717002531 pyrophosphate binding site [ion binding]; other site 436717002532 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 436717002533 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase...; Region: OAT_like; cd00610 436717002534 inhibitor-cofactor binding pocket; inhibition site 436717002535 pyridoxal 5'-phosphate binding site [chemical binding]; other site 436717002536 catalytic residue [active] 436717002537 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; cl00668 436717002538 Phosphopantetheine attachment site; Region: PP-binding; cl09936 436717002539 PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF...; Region: PseudoU_synth_RluCD_like; cd02869 436717002540 active site 436717002541 ATP-dependent helicase HepA; Validated; Region: PRK04914 436717002542 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 436717002543 ATP binding site [chemical binding]; other site 436717002544 putative Mg++ binding site [ion binding]; other site 436717002545 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 436717002546 nucleotide binding region [chemical binding]; other site 436717002547 ATP-binding site [chemical binding]; other site 436717002548 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 436717002549 DNA-binding transcriptional repressor FabR; Provisional; Region: PRK11202 436717002550 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 436717002551 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_2; cd06216 436717002552 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 436717002553 FAD binding pocket [chemical binding]; other site 436717002554 FAD binding motif [chemical binding]; other site 436717002555 phosphate binding motif [ion binding]; other site 436717002556 beta-alpha-beta structure motif; other site 436717002557 NAD binding pocket [chemical binding]; other site 436717002558 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 436717002559 catalytic loop [active] 436717002560 iron binding site [ion binding]; other site 436717002561 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 436717002562 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These...; Region: Delta6-FADS-like; cd03506 436717002563 putative di-iron ligands [ion binding]; other site 436717002564 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 436717002565 CoenzymeA binding site [chemical binding]; other site 436717002566 subunit interaction site [polypeptide binding]; other site 436717002567 PHB binding site; other site 436717002568 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 436717002569 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 436717002570 Protein of unknown function (DUF541); Region: SIMPL; cl01077 436717002571 diaminobutyrate--2-oxoglutarate aminotransferase; Provisional; Region: PRK06931 436717002572 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase...; Region: OAT_like; cd00610 436717002573 inhibitor-cofactor binding pocket; inhibition site 436717002574 pyridoxal 5'-phosphate binding site [chemical binding]; other site 436717002575 catalytic residue [active] 436717002576 Glutamate decarboxylase and related PLP-dependent proteins [Amino acid transport and metabolism]; Region: GadB; COG0076 436717002577 DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450 436717002578 pyridoxal 5'-phosphate binding site [chemical binding]; other site 436717002579 catalytic residue [active] 436717002580 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 436717002581 Streptomyces aureofaciens putative aldehyde dehydrogenase AldA (AAD23400)-like; Region: ALDH_AldA-AAD23400; cd07106 436717002582 NAD(P) binding site [chemical binding]; other site 436717002583 catalytic residues [active] 436717002584 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 436717002585 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 436717002586 Pyruvate decarboxylase and related thiamine pyrophosphate-requiring enzymes [Carbohydrate transport and metabolism / Coenzyme metabolism / General function prediction only]; Region: COG3961 436717002587 Pyrimidine (PYR) binding domain of pyruvate decarboxylase (PDC), indolepyruvate decarboxylase (IPDC) and related proteins; Region: TPP_PYR_PDC_IPDC_like; cd07038 436717002588 dimer interface [polypeptide binding]; other site 436717002589 PYR/PP interface [polypeptide binding]; other site 436717002590 TPP binding site [chemical binding]; other site 436717002591 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 436717002592 TPP-binding module; composed of proteins similar to pyruvate decarboxylase (PDC) and indolepyruvate decarboxylase (IPDC). PDC, a key enzyme in alcoholic fermentation, catalyzes the conversion of pyruvate to acetaldehyde and CO2. It is able to utilize...; Region: TPP_PDC_IPDC; cd02005 436717002593 TPP-binding site [chemical binding]; other site 436717002594 dimer interface [polypeptide binding]; other site 436717002595 Transmembrane amino acid transporter protein; Region: Aa_trans; cl00524 436717002596 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 436717002597 Phosphate ATP-binding cassette transporter; Region: DUF3708; pfam12501 436717002598 phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138 436717002599 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 436717002600 dimer interface [polypeptide binding]; other site 436717002601 conserved gate region; other site 436717002602 putative PBP binding loops; other site 436717002603 ABC-ATPase subunit interface; other site 436717002604 Domain of unknown function (DUF3333); Region: DUF3333; pfam11812 436717002605 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 436717002606 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 436717002607 dimer interface [polypeptide binding]; other site 436717002608 conserved gate region; other site 436717002609 putative PBP binding loops; other site 436717002610 ABC-ATPase subunit interface; other site 436717002611 phosphate transporter ATP-binding protein; Provisional; Region: PRK14235 436717002612 Phosphate uptake is of fundamental importance in the cell physiology of bacteria because phosphate is required as a nutrient. The Pst system of E. coli comprises four distinct subunits encoded by the pstS, pstA, pstB, and pstC genes. The PstS protein...; Region: ABC_PstB_phosphate_transporter; cd03260 436717002613 Walker A/P-loop; other site 436717002614 ATP binding site [chemical binding]; other site 436717002615 Q-loop/lid; other site 436717002616 ABC transporter signature motif; other site 436717002617 Walker B; other site 436717002618 D-loop; other site 436717002619 H-loop/switch region; other site 436717002620 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 436717002621 tandem repeat interface [polypeptide binding]; other site 436717002622 oligomer interface [polypeptide binding]; other site 436717002623 active site residues [active] 436717002624 Predicted membrane protein (DUF2238); Region: DUF2238; cl01464 436717002625 adenylosuccinate lyase; Provisional; Region: PRK09285 436717002626 PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598 436717002627 tetramer interface [polypeptide binding]; other site 436717002628 active site 436717002629 Protein of unknown function (DUF489); Region: DUF489; cl01097 436717002630 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 436717002631 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs...; Region: tRNA_Me_trans; cd01998 436717002632 Contains a crystal structure of the Nudix hydrolase from Nitrosomonas europaea, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X...; Region: Nudix_Hydrolase_2; cd03675 436717002633 nudix motif; other site 436717002634 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 436717002635 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 436717002636 trimer interface [polypeptide binding]; other site 436717002637 putative metal binding site [ion binding]; other site 436717002638 Beta-lactamase; Region: Beta-lactamase; cl01009 436717002639 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 436717002640 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943 436717002641 Survival protein SurE; Region: SurE; cl00448 436717002642 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 436717002643 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 436717002644 putative peptidoglycan binding site; other site 436717002645 Peptidase family M23; Region: Peptidase_M23; pfam01551 436717002646 transcriptional regulator; Provisional; Region: PRK10632 436717002647 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 436717002648 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 436717002649 putative effector binding pocket; other site 436717002650 dimerization interface [polypeptide binding]; other site 436717002651 Predicted ATP-dependent protease [Posttranslational modification, protein turnover, chaperones]; Region: LonB; COG1067 436717002652 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 436717002653 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl11420 436717002654 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl11420 436717002655 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl11420 436717002656 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 436717002657 dimer interface [polypeptide binding]; other site 436717002658 active site 436717002659 metal binding site [ion binding]; metal-binding site 436717002660 glutathione binding site [chemical binding]; other site 436717002661 Membrane transport protein; Region: Mem_trans; cl09117 436717002662 Ribosomal protein L31; Region: Ribosomal_L31; cl00377 436717002663 PAS domain S-box; Region: sensory_box; TIGR00229 436717002664 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 436717002665 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cl14056 436717002666 elongation factor P; Validated; Region: PRK00529 436717002667 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 436717002668 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with N-formylmethionyl-...; Region: S1_EF-P_repeat_1; cd04470 436717002669 RNA binding site [nucleotide binding]; other site 436717002670 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with N-formylmethionyl-...; Region: S1_EF-P_repeat_2; cd05794 436717002671 RNA binding site [nucleotide binding]; other site 436717002672 Carbon starvation protein CstA; Region: CstA; cl00856 436717002673 Protein of unknown function (DUF466); Region: DUF466; cl01082 436717002674 chromosome segregation protein; Provisional; Region: PRK03918 436717002675 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 436717002676 Predicted ATP-binding protein involved in virulence [General function prediction only]; Region: COG3950 436717002677 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins...; Region: HNHc; cl00083 436717002678 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein...; Region: CSP_CDS; cd04458 436717002679 DNA-binding site [nucleotide binding]; DNA binding site 436717002680 RNA-binding motif; other site 436717002681 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 436717002682 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 436717002683 Chromate transporter; Region: Chromate_transp; pfam02417 436717002684 Chromate transporter; Region: Chromate_transp; pfam02417 436717002685 Chromate resistance exported protein; Region: Chrome_Resist; cl01744 436717002686 putative DNA-binding transcriptional regulator; Provisional; Region: PRK09791 436717002687 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 436717002688 dimerization interface [polypeptide binding]; other site 436717002689 DoxX; Region: DoxX; cl00976 436717002690 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein...; Region: Peptidase_M17; cl08294 436717002691 Predicted ornithine cyclodeaminase, mu-crystallin homolog [Amino acid transport and metabolism]; Region: COG2423 436717002692 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 436717002693 NAD(P) binding site [chemical binding]; other site 436717002694 serine/threonine dehydratase; Validated; Region: PRK07048 436717002695 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 436717002696 tetramer interface [polypeptide binding]; other site 436717002697 pyridoxal 5'-phosphate binding site [chemical binding]; other site 436717002698 catalytic residue [active] 436717002699 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964 436717002700 YheO-like PAS domain; Region: PAS_6; pfam08348 436717002701 Pirin-related protein [General function prediction only]; Region: COG1741 436717002702 Cupin domain; Region: Cupin_2; cl09118 436717002703 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 436717002704 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 436717002705 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 436717002706 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This...; Region: URO-D; cd00717 436717002707 substrate binding site [chemical binding]; other site 436717002708 active site 436717002709 Protein of unknown function (DUF817); Region: DUF817; cl01520 436717002710 Protein of unknown function (DUF3015); Region: DUF3015; pfam11220 436717002711 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 436717002712 Beta-lactamase; Region: Beta-lactamase; cl01009 436717002713 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 436717002714 homodecamer interface [polypeptide binding]; other site 436717002715 GTP cyclohydrolase I; Provisional; Region: PLN03044 436717002716 active site 436717002717 putative catalytic site residues [active] 436717002718 zinc binding site [ion binding]; other site 436717002719 GTP-CH-I/GFRP interaction surface; other site 436717002720 xanthine dehydrogenase, small subunit; Region: xanthine_xdhA; TIGR02963 436717002721 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 436717002722 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450 436717002723 xanthine dehydrogenase, molybdopterin binding subunit; Region: xanthine_xdhB; TIGR02965 436717002724 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; pfam01315 436717002725 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 436717002726 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 436717002727 xanthine dehydrogenase accessory protein XdhC; Region: xanthine_xdhC; TIGR02964 436717002728 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2840 436717002729 Smr domain; Region: Smr; cl02619 436717002730 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 436717002731 active site 436717002732 ribulose/triose binding site [chemical binding]; other site 436717002733 phosphate binding site [ion binding]; other site 436717002734 substrate (anthranilate) binding pocket [chemical binding]; other site 436717002735 product (indole) binding pocket [chemical binding]; other site 436717002736 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 436717002737 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 436717002738 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 436717002739 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 436717002740 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 436717002741 glutamine binding [chemical binding]; other site 436717002742 catalytic triad [active] 436717002743 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 436717002744 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 436717002745 X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline...; Region: APP; cd01085 436717002746 active site 436717002747 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 436717002748 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 436717002749 putative substrate translocation pore; other site 436717002750 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl11420 436717002751 glutamine synthetase; Provisional; Region: glnA; PRK09469 436717002752 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 436717002753 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 436717002754 Chorismate lyase; Region: Chor_lyase; cl01230 436717002755 UbiA prenyltransferase family; Region: UbiA; cl00337 436717002756 Secretory lipase; Region: LIP; pfam03583 436717002757 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 436717002758 putative active site [active] 436717002759 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 436717002760 superoxide dismutase; Provisional; Region: PRK10543 436717002761 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 436717002762 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl01309 436717002763 Uncharacterized conserved protein [Function unknown]; Region: COG0327 436717002764 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic...; Region: Tryp_SPc; cl00149 436717002765 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind C-...; Region: PDZ_serine_protease; cd00987 436717002766 protein binding site [polypeptide binding]; other site 436717002767 multifunctional tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase; Reviewed; Region: cca; PRK10885 436717002768 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 436717002769 active site 436717002770 NTP binding site [chemical binding]; other site 436717002771 metal binding triad [ion binding]; metal-binding site 436717002772 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 436717002773 bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed; Region: PRK07232 436717002774 Malic enzyme, N-terminal domain; Region: malic; pfam00390 436717002775 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 436717002776 putative NAD(P) binding site [chemical binding]; other site 436717002777 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390 436717002778 RNase II stability modulator; Provisional; Region: PRK10060 436717002779 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 436717002780 putative active site [active] 436717002781 heme pocket [chemical binding]; other site 436717002782 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 436717002783 metal binding site [ion binding]; metal-binding site 436717002784 active site 436717002785 I-site; other site 436717002786 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 436717002787 RNA methyltransferase; Region: Methyltrans_RNA; cl00611 436717002788 Methylenetetrahydrofolate reductase; Region: MTHFR; pfam02219 436717002789 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine...; Region: MTHFR; cd00537 436717002790 FAD binding site [chemical binding]; other site 436717002791 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 436717002792 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 436717002793 oligomerization interface [polypeptide binding]; other site 436717002794 active site 436717002795 NAD+ binding site [chemical binding]; other site 436717002796 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the 'double-glycine' leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic). The...; Region: Peptidase_C39_like; cl00296 436717002797 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 436717002798 acyl-CoA dehydrogenase; Reviewed; Region: fadE; PRK09463 436717002799 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 436717002800 active site 436717002801 Domain of unknown function (DUF1974); Region: DUF1974; pfam09317 436717002802 lipoyl synthase; Provisional; Region: PRK05481 436717002803 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cl14056 436717002804 soluble pyridine nucleotide transhydrogenase; Provisional; Region: PRK05249 436717002805 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 436717002806 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 436717002807 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 436717002808 Major Facilitator Superfamily; Region: MFS_1; pfam07690 436717002809 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 436717002810 nitrate transmembrane transporter; Provisional; Region: PLN00028 436717002811 Surface antigen; Region: Surface_Ag_2; cl01155 436717002812 methionine aminopeptidase; Reviewed; Region: PRK07281 436717002813 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 436717002814 active site 436717002815 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 436717002816 rRNA interaction site [nucleotide binding]; other site 436717002817 S8 interaction site; other site 436717002818 putative laminin-1 binding site; other site 436717002819 elongation factor Ts; Provisional; Region: tsf; PRK09377 436717002820 Ubiquitin Associated domain. The UBA domain is a commonly occurring sequence motif in some members of the ubiquitination pathway, UV excision repair proteins, and certain protein kinases. Although its specific role is so far unknown, it has been...; Region: UBA; cl00153 436717002821 Elongation factor TS; Region: EF_TS; pfam00889 436717002822 Elongation factor TS; Region: EF_TS; pfam00889 436717002823 Protein of unknown function (DUF3465); Region: DUF3465; pfam11948 436717002824 Cupin domain; Region: Cupin_2; cl09118 436717002825 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 436717002826 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 436717002827 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 436717002828 AzlC protein; Region: AzlC; cl00570 436717002829 Branched-chain amino acid transport protein (AzlD); Region: AzlD; cl00735 436717002830 Protein of unknown function (DUF962); Region: DUF962; cl01879 436717002831 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; cl04011 436717002832 lytic murein transglycosylase; Region: MltB_2; TIGR02283 436717002833 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 436717002834 N-acetyl-D-glucosamine binding site [chemical binding]; other site 436717002835 catalytic residue [active] 436717002836 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 436717002837 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2904 436717002838 7-cyano-7-deazaguanine reductase; Provisional; Region: queF; PRK11792 436717002839 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 436717002840 ABC-2 type transporter; Region: ABC2_membrane; cl11417 436717002841 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 436717002842 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 436717002843 Walker A/P-loop; other site 436717002844 ATP binding site [chemical binding]; other site 436717002845 Q-loop/lid; other site 436717002846 ABC transporter signature motif; other site 436717002847 Walker B; other site 436717002848 D-loop; other site 436717002849 H-loop/switch region; other site 436717002850 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 436717002851 exodeoxyribonuclease X; Provisional; Region: PRK07983 436717002852 active site 436717002853 substrate binding site [chemical binding]; other site 436717002854 catalytic site [active] 436717002855 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 436717002856 Secretory lipase; Region: LIP; pfam03583 436717002857 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of...; Region: SHMT; cd00378 436717002858 dimer interface [polypeptide binding]; other site 436717002859 glycine-pyridoxal phosphate binding site [chemical binding]; other site 436717002860 active site 436717002861 folate binding site [chemical binding]; other site 436717002862 NodT family; Region: outer_NodT; TIGR01845 436717002863 Outer membrane efflux protein; Region: OEP; pfam02321 436717002864 Outer membrane efflux protein; Region: OEP; pfam02321 436717002865 AcrB/AcrD/AcrF family; Region: ACR_tran; pfam00873 436717002866 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 436717002867 Transcriptional regulator [Transcription]; Region: LysR; COG0583 436717002868 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 436717002869 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 436717002870 putative effector binding pocket; other site 436717002871 putative dimerization interface [polypeptide binding]; other site 436717002872 lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096 436717002873 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and...; Region: PBPb; cd00134 436717002874 substrate binding pocket [chemical binding]; other site 436717002875 membrane-bound complex binding site; other site 436717002876 hinge residues; other site 436717002877 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 436717002878 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 436717002879 dimer interface [polypeptide binding]; other site 436717002880 conserved gate region; other site 436717002881 putative PBP binding loops; other site 436717002882 ABC-ATPase subunit interface; other site 436717002883 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 436717002884 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 436717002885 dimer interface [polypeptide binding]; other site 436717002886 conserved gate region; other site 436717002887 putative PBP binding loops; other site 436717002888 ABC-ATPase subunit interface; other site 436717002889 ABC-type histidine transport system, ATPase component [Amino acid transport and metabolism]; Region: HisP; COG4598 436717002890 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP; Region: ABC_HisP_GlnQ_permeases; cd03262 436717002891 Walker A/P-loop; other site 436717002892 ATP binding site [chemical binding]; other site 436717002893 Q-loop/lid; other site 436717002894 ABC transporter signature motif; other site 436717002895 Walker B; other site 436717002896 D-loop; other site 436717002897 H-loop/switch region; other site 436717002898 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 436717002899 archaeoflavoprotein, MJ0208 family; Region: flavo_MJ0208; TIGR02700 436717002900 putative protease; Provisional; Region: PRK15452 436717002901 Peptidase family U32; Region: Peptidase_U32; cl03113 436717002902 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 436717002903 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 436717002904 DNA-binding site [nucleotide binding]; DNA binding site 436717002905 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 436717002906 pyridoxal 5'-phosphate binding site [chemical binding]; other site 436717002907 homodimer interface [polypeptide binding]; other site 436717002908 catalytic residue [active] 436717002909 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 436717002910 Diaminopimelate epimerase; Region: DAP_epimerase; cl14668 436717002911 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 436717002912 Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195 436717002913 FAD binding pocket [chemical binding]; other site 436717002914 FAD binding motif [chemical binding]; other site 436717002915 phosphate binding motif [ion binding]; other site 436717002916 beta-alpha-beta structure motif; other site 436717002917 NAD binding pocket [chemical binding]; other site 436717002918 Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281 436717002919 homodimer interaction site [polypeptide binding]; other site 436717002920 cofactor binding site; other site 436717002921 Predicted membrane protein [Function unknown]; Region: COG3174 436717002922 GSPII_E N-terminal domain; Region: GSPII_E_N; pfam05157 436717002923 Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804 436717002924 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 436717002925 Walker A motif; other site 436717002926 ATP binding site [chemical binding]; other site 436717002927 Walker B motif; other site 436717002928 Bacterial OB fold (BOF) protein; Region: BOF; cl01196 436717002929 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 436717002930 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 436717002931 active site 436717002932 phosphorylation site [posttranslational modification] 436717002933 intermolecular recognition site; other site 436717002934 dimerization interface [polypeptide binding]; other site 436717002935 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 436717002936 DNA binding site [nucleotide binding] 436717002937 sensor protein QseC; Provisional; Region: PRK10337 436717002938 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 436717002939 dimer interface [polypeptide binding]; other site 436717002940 phosphorylation site [posttranslational modification] 436717002941 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 436717002942 ATP binding site [chemical binding]; other site 436717002943 Mg2+ binding site [ion binding]; other site 436717002944 G-X-G motif; other site 436717002945 hypothetical protein; Provisional; Region: PRK08999 436717002946 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 436717002947 active site 436717002948 8-oxo-dGMP binding site [chemical binding]; other site 436717002949 nudix motif; other site 436717002950 metal binding site [ion binding]; metal-binding site 436717002951 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5- (beta-...; Region: TMP_TenI; cd00564 436717002952 thiamine phosphate binding site [chemical binding]; other site 436717002953 active site 436717002954 penicillin-binding protein 1B; Region: PBP_1b; TIGR02071 436717002955 Transglycosylase; Region: Transgly; cl07896 436717002956 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01039 436717002957 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 436717002958 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02231 436717002959 Protein of unknown function (DUF1315); Region: DUF1315; cl01215 436717002960 hypothetical protein; Validated; Region: PRK09071 436717002961 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 436717002962 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 436717002963 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 436717002964 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 436717002965 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 436717002966 active site 436717002967 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 436717002968 Chorismate mutase type II; Region: CM_2; cl00693 436717002969 Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077 436717002970 Prephenate dehydratase; Region: PDT; pfam00800 436717002971 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 436717002972 putative L-Phe binding site [chemical binding]; other site 436717002973 bifunctional cyclohexadienyl dehydrogenase/ 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK14806 436717002974 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 436717002975 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form 5-enolpyruvylshkimate-3-...; Region: EPSP_synthase; cd01556 436717002976 hinge; other site 436717002977 active site 436717002978 aminoacyl-histidine dipeptidase; Region: aa-his-dipept; TIGR01893 436717002979 M20 Peptidase D has specificity for beta-alanyl-L-histidine dipeptide; Region: M20_pepD; cd03890 436717002980 metal binding site [ion binding]; metal-binding site 436717002981 dimer interface [polypeptide binding]; other site 436717002982 RNA 3'-terminal-phosphate cyclase; Provisional; Region: PRK04204 436717002983 This domain family includes the Enolpyruvate transferase (EPT) family and the RNA 3' phosphate cyclase family (RTPC). These 2 families differ in that EPT is formed by 3 repeats of an alpha-beta structural domain while RTPC has 3 similar repeats with a...; Region: EPT_RTPC-like; cl00288 436717002984 putative active site [active] 436717002985 potential frameshift: common BLAST hit: gi|260414702|ref|YP_003208314.1| septicolysin 436717002986 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a...; Region: Hint; cl12032 436717002987 hypothetical protein; Reviewed; Region: PRK09588 436717002988 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 436717002989 Sigma54-dependent transcription regulator containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: RtcR; COG4650 436717002990 Regulator of RNA terminal phosphate cyclase; Region: RtcR; pfam06956 436717002991 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 436717002992 Walker A motif; other site 436717002993 ATP binding site [chemical binding]; other site 436717002994 Walker B motif; other site 436717002995 arginine finger; other site 436717002996 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2945 436717002997 Protein of unknown function (DUF328); Region: DUF328; cl01143 436717002998 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 436717002999 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 436717003000 ThiS interaction site; other site 436717003001 putative active site [active] 436717003002 tetramer interface [polypeptide binding]; other site 436717003003 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 436717003004 thiS-thiF/thiG interaction site; other site 436717003005 Protein of unknown function (DUF423); Region: DUF423; cl01008 436717003006 RNA polymerase factor sigma-32; Reviewed; Region: PRK06596 436717003007 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 436717003008 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171 436717003009 DNA binding residues [nucleotide binding] 436717003010 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this two-...; Region: SirA_YedF_YeeD; cd00291 436717003011 CPxP motif; other site 436717003012 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein...; Region: CSP_CDS; cd04458 436717003013 DNA-binding site [nucleotide binding]; DNA binding site 436717003014 RNA-binding motif; other site 436717003015 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (...; Region: DEADc; cd00268 436717003016 DEAD-like helicases superfamily; Region: DEXDc; smart00487 436717003017 ATP binding site [chemical binding]; other site 436717003018 Mg++ binding site [ion binding]; other site 436717003019 motif III; other site 436717003020 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 436717003021 nucleotide binding region [chemical binding]; other site 436717003022 ATP-binding site [chemical binding]; other site 436717003023 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a beta-...; Region: Arsenite_oxidase; cd02135 436717003024 putative FMN binding site [chemical binding]; other site 436717003025 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 436717003026 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 436717003027 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 436717003028 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 436717003029 catalytic core [active] 436717003030 GspL cytoplasmic actin-ATPase-like region; Region: GspL; pfam05134 436717003031 GspL periplasmic domain; Region: GspL_C; cl14909 436717003032 General secretion pathway, M protein; Region: GspM; cl01222 436717003033 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD...; Region: DHOD_2_like; cd04738 436717003034 quinone interaction residues [chemical binding]; other site 436717003035 Dihydroorotate dehydrogenase [Nucleotide transport and metabolism]; Region: PyrD; COG0167 436717003036 active site 436717003037 catalytic residues [active] 436717003038 FMN binding site [chemical binding]; other site 436717003039 substrate binding site [chemical binding]; other site 436717003040 Colicin V production protein; Region: Colicin_V; cl00567 436717003041 amidophosphoribosyltransferase; Provisional; Region: PRK09246 436717003042 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 436717003043 active site 436717003044 tetramer interface [polypeptide binding]; other site 436717003045 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 436717003046 Peptidase family M48; Region: Peptidase_M48; cl12018 436717003047 bifunctional glyoxylate/hydroxypyruvate reductase B; Provisional; Region: PRK15409 436717003048 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 436717003049 Putative Zn-dependent protease, contains TPR repeats [General function prediction only]; Region: COG4783 436717003050 Peptidase family M48; Region: Peptidase_M48; cl12018 436717003051 GatB domain; Region: GatB_Yqey; cl11497 436717003052 Ribosomal protein S21; Region: Ribosomal_S21; cl00529 436717003053 UGMP family protein; Validated; Region: PRK09604 436717003054 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl14000 436717003055 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 436717003056 Domain of unknown function (DUF3336); Region: DUF3336; pfam11815 436717003057 Triacylglycerol lipase 3, 4, and 5 and Sugar-Dependent 1 lipase; Region: Pat_TGL3-4-5_SDP1; cd07206 436717003058 active site 436717003059 nucleophile elbow; other site 436717003060 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 436717003061 substrate binding site [chemical binding]; other site 436717003062 activation loop (A-loop); other site 436717003063 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 436717003064 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein...; Region: CSP_CDS; cd04458 436717003065 DNA-binding site [nucleotide binding]; DNA binding site 436717003066 RNA-binding motif; other site 436717003067 Sensors of blue-light using FAD; Region: BLUF; pfam04940 436717003068 LysE type translocator; Region: LysE; cl00565 436717003069 Cupin domain; Region: Cupin_2; cl09118 436717003070 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 436717003071 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 436717003072 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 436717003073 putative efflux protein, MATE family; Region: matE; TIGR00797 436717003074 MatE; Region: MatE; pfam01554 436717003075 MatE; Region: MatE; pfam01554 436717003076 NodT family; Region: outer_NodT; TIGR01845 436717003077 Outer membrane efflux protein; Region: OEP; pfam02321 436717003078 Outer membrane efflux protein; Region: OEP; pfam02321 436717003079 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 436717003080 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 436717003081 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 436717003082 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 436717003083 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 436717003084 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 436717003085 NADP binding site [chemical binding]; other site 436717003086 active site 436717003087 steroid binding site; other site 436717003088 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 436717003089 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 436717003090 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 436717003091 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 436717003092 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 436717003093 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 436717003094 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 436717003095 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 436717003096 Fatty acid desaturase; Region: FA_desaturase; pfam00487 436717003097 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These...; Region: Delta6-FADS-like; cd03506 436717003098 putative di-iron ligands [ion binding]; other site 436717003099 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 436717003100 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron...; Region: FNR_like; cl06868 436717003101 FAD binding pocket [chemical binding]; other site 436717003102 conserved FAD binding motif [chemical binding]; other site 436717003103 phosphate binding motif [ion binding]; other site 436717003104 beta-alpha-beta structure motif; other site 436717003105 NAD binding pocket [chemical binding]; other site 436717003106 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 436717003107 catalytic loop [active] 436717003108 iron binding site [ion binding]; other site 436717003109 PhaC subunit; Region: PHA_synth_III_C; TIGR01836 436717003110 Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167 436717003111 sodium--glutamate symport carrier (gltS); Region: gltS; TIGR00210 436717003112 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 436717003113 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 436717003114 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 436717003115 short chain dehydrogenase; Provisional; Region: PRK06101 436717003116 classical (c) SDRs; Region: SDR_c; cd05233 436717003117 NAD(P) binding site [chemical binding]; other site 436717003118 active site 436717003119 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 436717003120 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 436717003121 aspartate 4-decarboxylase; Region: asp_4_decarbox; TIGR03801 436717003122 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 436717003123 pyridoxal 5'-phosphate binding site [chemical binding]; other site 436717003124 homodimer interface [polypeptide binding]; other site 436717003125 catalytic residue [active] 436717003126 aspartate-alanine antiporter; Region: Asp_Ala_antiprt; TIGR03802 436717003127 Predicted Permease Membrane Region; Region: Asp-Al_Ex; cl06061 436717003128 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110 436717003129 Predicted Permease Membrane Region; Region: Asp-Al_Ex; cl06061 436717003130 Paraquat-inducible protein A; Region: PqiA; pfam04403 436717003131 Paraquat-inducible protein A; Region: PqiA; pfam04403 436717003132 Paraquat-inducible protein B [General function prediction only]; Region: PqiB; COG3008 436717003133 mce related protein; Region: MCE; cl03606 436717003134 mce related protein; Region: MCE; cl03606 436717003135 mce related protein; Region: MCE; cl03606 436717003136 Protein of unknown function (DUF330); Region: DUF330; cl01135 436717003137 HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU)...; Region: TLP_HIUase; cd05822 436717003138 active site 436717003139 homotetramer interface [polypeptide binding]; other site 436717003140 Domain of unknown function (DUF336); Region: DUF336; cl01249 436717003141 heavy metal response regulator; Region: cztR_silR_copR; TIGR01387 436717003142 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 436717003143 active site 436717003144 phosphorylation site [posttranslational modification] 436717003145 intermolecular recognition site; other site 436717003146 dimerization interface [polypeptide binding]; other site 436717003147 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 436717003148 DNA binding site [nucleotide binding] 436717003149 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 436717003150 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 436717003151 dimer interface [polypeptide binding]; other site 436717003152 phosphorylation site [posttranslational modification] 436717003153 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 436717003154 ATP binding site [chemical binding]; other site 436717003155 Mg2+ binding site [ion binding]; other site 436717003156 G-X-G motif; other site 436717003157 Lipocalin / cytosolic fatty-acid binding protein family; Region: Lipocalin; cl01150 436717003158 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 436717003159 Di-iron ligands [ion binding]; other site 436717003160 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 436717003161 Predicted NAD/FAD-binding protein [General function prediction only]; Region: COG2907 436717003162 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 436717003163 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 436717003164 Protein of unknown function (DUF1365); Region: DUF1365; cl01388 436717003165 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 436717003166 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 436717003167 S-adenosylmethionine binding site [chemical binding]; other site 436717003168 Isoprenylcysteine carboxyl methyltransferase (ICMT) family; Region: ICMT; cl00763 436717003169 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 436717003170 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 436717003171 S-adenosylmethionine binding site [chemical binding]; other site 436717003172 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 436717003173 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 436717003174 dimer interface [polypeptide binding]; other site 436717003175 phosphorylation site [posttranslational modification] 436717003176 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 436717003177 ATP binding site [chemical binding]; other site 436717003178 Mg2+ binding site [ion binding]; other site 436717003179 G-X-G motif; other site 436717003180 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 436717003181 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 436717003182 active site 436717003183 phosphorylation site [posttranslational modification] 436717003184 intermolecular recognition site; other site 436717003185 dimerization interface [polypeptide binding]; other site 436717003186 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 436717003187 DNA binding site [nucleotide binding] 436717003188 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 436717003189 aspartate racemase; Region: asp_race; TIGR00035 436717003190 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 436717003191 quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754 436717003192 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 436717003193 NADP binding site [chemical binding]; other site 436717003194 dimer interface [polypeptide binding]; other site 436717003195 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG...; Region: CAS_like; cl00184 436717003196 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 436717003197 Prokaryotic protein of unknown function (DUF849); Region: DUF849; cl01276 436717003198 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 436717003199 Major Facilitator Superfamily; Region: MFS_1; pfam07690 436717003200 putative substrate translocation pore; other site 436717003201 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 436717003202 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 436717003203 catalytic residues [active] 436717003204 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1)...; Region: Rieske; cl00938 436717003205 iron-sulfur cluster [ion binding]; other site 436717003206 [2Fe-2S] cluster binding site [ion binding]; other site 436717003207 Conserved hypothetical protein 698; Region: Cons_hypoth698; cl01075 436717003208 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 436717003209 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 436717003210 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 436717003211 Protein of unknown function (DUF1302); Region: DUF1302; pfam06980 436717003212 Protein of unknown function (DUF1200); Region: DUF1200; pfam06713 436717003213 Membrane bound L-sorbosone dehydrogenase; Region: SNDH; pfam12303 436717003214 Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133 436717003215 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 436717003216 benzoate transport; Region: 2A0115; TIGR00895 436717003217 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 436717003218 putative substrate translocation pore; other site 436717003219 Transcriptional regulator [Transcription]; Region: LysR; COG0583 436717003220 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 436717003221 The C-terminal substrate binding domain of LysR-type transcriptional regulators that are involved in the catabolism of dinitrotoluene, naphthalene and gamma-hexachlorohexane; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_NahR_LinR_like; cd08459 436717003222 substrate binding pocket [chemical binding]; other site 436717003223 dimerization interface [polypeptide binding]; other site 436717003224 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; cl01132 436717003225 GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins...; Region: GST_N_GTT1_like; cd03046 436717003226 putative C-terminal domain interface [polypeptide binding]; other site 436717003227 putative GSH binding site (G-site) [chemical binding]; other site 436717003228 maleylacetoacetate isomerase; Region: maiA; TIGR01262 436717003229 putative dimer interface [polypeptide binding]; other site 436717003230 Glutathione S-transferase (GST) family, C-terminal alpha helical domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and...; Region: GST_C_family; cd00299 436717003231 dimer interface [polypeptide binding]; other site 436717003232 substrate binding pocket (H-site) [chemical binding]; other site 436717003233 N-terminal domain interface [polypeptide binding]; other site 436717003234 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl11420 436717003235 Major Facilitator Superfamily; Region: MFS_1; pfam07690 436717003236 putative substrate translocation pore; other site 436717003237 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 436717003238 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 436717003239 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 436717003240 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 436717003241 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 436717003242 dimer interface [polypeptide binding]; other site 436717003243 conserved gate region; other site 436717003244 ABC-ATPase subunit interface; other site 436717003245 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 436717003246 MetN (also known as YusC) is an ABC-type transporter encoded by metN of the metNPQ operon in Bacillus subtilis that is involved in methionine transport. Other members of this system include the MetP permease and the MetQ substrate binding protein; Region: ABC_MetN_methionine_transporter; cd03258 436717003247 Walker A/P-loop; other site 436717003248 ATP binding site [chemical binding]; other site 436717003249 Q-loop/lid; other site 436717003250 ABC transporter signature motif; other site 436717003251 Walker B; other site 436717003252 D-loop; other site 436717003253 H-loop/switch region; other site 436717003254 NIL domain; Region: NIL; pfam09383 436717003255 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 436717003256 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 436717003257 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 436717003258 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 436717003259 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 436717003260 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 436717003261 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates 5-aminoimidazole-4-carboxamide-; Region: IMPCH; cd01421 436717003262 purine monophosphate binding site [chemical binding]; other site 436717003263 dimer interface [polypeptide binding]; other site 436717003264 putative catalytic residues [active] 436717003265 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 436717003266 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 436717003267 Bacterial regulatory protein, Fis family; Region: HTH_8; cl01091 436717003268 MJ0042 family finger-like domain; Region: MJ0042_CXXC; TIGR02098 436717003269 Protein of unknown function (DUF3426); Region: DUF3426; pfam11906 436717003270 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 436717003271 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 436717003272 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; cl11520 436717003273 Flavin-dependent tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA [Cell cycle control, cell division, chromosome partitioning]; Region: GidA; COG0445 436717003274 Predicted transcriptional regulator [Transcription]; Region: COG2378 436717003275 DnaQ family exonuclease/DinG family helicase, putative; Region: dinG_rel; TIGR01407 436717003276 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 436717003277 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 436717003278 Transglutaminase-like superfamily; Region: Transglut_core; cl10469 436717003279 Predicted proteasome-type protease [Posttranslational modification, protein turnover, chaperones]; Region: COG3484 436717003280 Bacterial proteasome, beta subunit. The 20S proteasome, multisubunit proteolytic complex, is the central enzyme of nonlysosomal protein degradation in both the cytosol and nucleus. It is composed of 28 subunits arranged as four homoheptameric rings...; Region: proteasome_beta_bacterial; cd03765 436717003281 alanine racemase; Reviewed; Region: alr; PRK00053 436717003282 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827 436717003283 active site 436717003284 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 436717003285 substrate binding site [chemical binding]; other site 436717003286 catalytic residues [active] 436717003287 dimer interface [polypeptide binding]; other site 436717003288 replicative DNA helicase; Region: DnaB; TIGR00665 436717003289 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 436717003290 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 436717003291 Walker A motif; other site 436717003292 ATP binding site [chemical binding]; other site 436717003293 Walker B motif; other site 436717003294 DNA binding loops [nucleotide binding] 436717003295 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 436717003296 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 436717003297 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 436717003298 Ribosomal protein S18; Region: Ribosomal_S18; cl00373 436717003299 Ribosomal protein S6; Region: Ribosomal_S6; cl00414 436717003300 UbiA prenyltransferase family; Region: UbiA; cl00337 436717003301 Prokaryotic Cytochrome C oxidase subunit IV; Region: COX4_pro; cl01204 436717003302 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 436717003303 Subunit I/III interface [polypeptide binding]; other site 436717003304 Subunit III/IV interface [polypeptide binding]; other site 436717003305 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 436717003306 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 436717003307 D-pathway; other site 436717003308 Putative ubiquinol binding site [chemical binding]; other site 436717003309 Low-spin heme (heme b) binding site [chemical binding]; other site 436717003310 Putative water exit pathway; other site 436717003311 Binuclear center (heme o3/CuB) [ion binding]; other site 436717003312 K-pathway; other site 436717003313 Putative proton exit pathway; other site 436717003314 cytochrome o ubiquinol oxidase subunit II; Provisional; Region: PRK10525 436717003315 COX Aromatic Rich Motif; Region: COX_ARM; pfam06481 436717003316 RDD family; Region: RDD; cl00746 436717003317 phosphoenolpyruvate synthase; Validated; Region: PRK06464 436717003318 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 436717003319 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 436717003320 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 436717003321 Domain of unknown function (DUF299); Region: DUF299; cl00780 436717003322 poly-beta-1,6 N-acetyl-D-glucosamine export porin PgaA; Region: PGA_TPR_OMP; TIGR03939 436717003323 poly-beta-1,6-N-acetyl-D-glucosamine N-deacetylase PgaB; Region: deacetyl_PgaB; TIGR03938 436717003324 Polysaccharide deacetylase; Region: Polysacc_deac_1; cl12061 436717003325 N-glycosyltransferase; Provisional; Region: PRK11204 436717003326 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 436717003327 DXD motif; other site 436717003328 hemin storage system protein; Provisional; Region: hmsS; cl14676 436717003329 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 436717003330 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 436717003331 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 436717003332 peptide chain release factor 1; Validated; Region: prfA; PRK00591 436717003333 RF-1 domain; Region: RF-1; cl02875 436717003334 RF-1 domain; Region: RF-1; cl02875 436717003335 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 436717003336 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 436717003337 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 436717003338 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 436717003339 ABC-ATPase subunit interface; other site 436717003340 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 436717003341 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and...; Region: PBPb; cd00134 436717003342 substrate binding pocket [chemical binding]; other site 436717003343 membrane-bound complex binding site; other site 436717003344 hinge residues; other site 436717003345 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 436717003346 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 436717003347 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 436717003348 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 436717003349 17hydroxysteroid dehydrogenase type 10 (HSD10)-like, classical (c) SDRs; Region: HSD10-like_SDR_c; cd05371 436717003350 NAD binding site [chemical binding]; other site 436717003351 homotetramer interface [polypeptide binding]; other site 436717003352 homodimer interface [polypeptide binding]; other site 436717003353 active site 436717003354 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 436717003355 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 436717003356 active site 436717003357 Flavin Reductases; Region: FlaRed; cl00801 436717003358 molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690 436717003359 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of...; Region: ThiF_MoeB_HesA_family; cd00757 436717003360 ATP binding site [chemical binding]; other site 436717003361 substrate interface [chemical binding]; other site 436717003362 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 436717003363 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines...; Region: DHNA_DHNTPE; cd00534 436717003364 homooctamer interface [polypeptide binding]; other site 436717003365 active site 436717003366 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cl00233 436717003367 catalytic center binding site [active] 436717003368 ATP binding site [chemical binding]; other site 436717003369 K+-transporting ATPase, A chain [Inorganic ion transport and metabolism]; Region: KdpA; cl00903 436717003370 Potassium-transporting ATPase A subunit; Region: KdpA; pfam03814 436717003371 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 436717003372 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 436717003373 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 436717003374 K+-transporting ATPase, c chain; Region: KdpC; cl00944 436717003375 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 436717003376 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 436717003377 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 436717003378 Ligand Binding Site [chemical binding]; other site 436717003379 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 436717003380 dimer interface [polypeptide binding]; other site 436717003381 phosphorylation site [posttranslational modification] 436717003382 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 436717003383 ATP binding site [chemical binding]; other site 436717003384 Mg2+ binding site [ion binding]; other site 436717003385 G-X-G motif; other site 436717003386 DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529 436717003387 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 436717003388 active site 436717003389 phosphorylation site [posttranslational modification] 436717003390 intermolecular recognition site; other site 436717003391 dimerization interface [polypeptide binding]; other site 436717003392 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 436717003393 DNA binding site [nucleotide binding] 436717003394 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 436717003395 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 436717003396 Protein of unknown function (DUF2799); Region: DUF2799; pfam10973 436717003397 Demethoxyubiquinone hydroxylase, ferritin-like diiron-binding domain; Region: DMQH; cd01042 436717003398 diiron binding motif [ion binding]; other site 436717003399 acylglycerophosphoethanolamine acyltransferase; Provisional; Region: PRK06814 436717003400 Outer membrane protein/protective antigen OMA87 [Cell envelope biogenesis, outer membrane]; Region: COG4775 436717003401 Surface antigen; Region: Bac_surface_Ag; cl03097 436717003402 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911 436717003403 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911 436717003404 Family of unknown function (DUF490); Region: DUF490; pfam04357 436717003405 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 436717003406 bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238 436717003407 Aconitase B swivel domain. Aconitate hydratase B is involved in energy metabolism as part of the TCA cycle. It catalyses the formation of cis-aconitate from citrate. This is the aconitase swivel domain, which undergoes swivelling conformational change...; Region: AcnB_Swivel; cd01576 436717003408 substrate binding site [chemical binding]; other site 436717003409 Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle; Region: AcnB; cd01581 436717003410 substrate binding site [chemical binding]; other site 436717003411 ligand binding site [chemical binding]; other site 436717003412 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110 436717003413 transmembrane helices; other site 436717003414 Ion transport protein; Region: Ion_trans; pfam00520 436717003415 Ion channel; Region: Ion_trans_2; cl11596 436717003416 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 436717003417 putative substrate translocation pore; other site 436717003418 Major Facilitator Superfamily; Region: MFS_1; pfam07690 436717003419 Nickel uptake substrate-specific transmembrane region; Region: NikM; pfam10670 436717003420 Transcriptional regulator [Transcription]; Region: LysR; COG0583 436717003421 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 436717003422 The C-terminal substrate binding domain of LysR-type transcriptional regulator metR, which regulates the expression of methionine biosynthetic genes, contains type 2 periplasmic binding fold; Region: PBP2_MetR; cd08441 436717003423 putative dimerization interface [polypeptide binding]; other site 436717003424 Protein of unknown function (DUF441); Region: DUF441; cl01041 436717003425 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 436717003426 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 436717003427 PseudoU_synth_RsuA: Pseudouridine synthase, Escherichia coli RsuA like. This group is comprised of eukaryotic and bacterial proteins similar to Escherichia coli RsuA. Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA...; Region: PseudoU_synth_RsuA; cd02553 436717003428 active site 436717003429 uracil binding [chemical binding]; other site 436717003430 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 436717003431 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 436717003432 Coenzyme A binding pocket [chemical binding]; other site 436717003433 RelB antitoxin; Region: RelB; cl01171 436717003434 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 436717003435 PSRA_1: Pseudouridine synthase, a subgroup of the RluA family. This group is comprised of bacterial proteins assigned to the RluA family of pseudouridine synthases. Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA...; Region: PSRA_1; cd02558 436717003436 probable active site [active] 436717003437 Uncharacterised P-loop hydrolase UPF0079; Region: UPF0079; cl00520 436717003438 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 436717003439 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 436717003440 MutL_Trans_MutL: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to Escherichia coli MutL. EcMutL belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second...; Region: MutL_Trans_MutL; cd03482 436717003441 ATP binding site [chemical binding]; other site 436717003442 MutL C terminal dimerisation domain; Region: MutL_C; cl07336 436717003443 IPP transferase; Region: IPPT; cl00403 436717003444 Hfq, an abundant, ubiquitous RNA-binding protein, functions as a pleiotrophic regulator of RNA metabolism in prokaryotes, required for transcription of some transcripts and degradation of others. Hfq binds small RNA molecules called riboregulators that...; Region: Hfq; cd01716 436717003445 Sm1 motif; other site 436717003446 intra - hexamer interaction site; other site 436717003447 inter - hexamer interaction site [polypeptide binding]; other site 436717003448 nucleotide binding pocket [chemical binding]; other site 436717003449 Sm2 motif; other site 436717003450 NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149 436717003451 dimer interface [polypeptide binding]; other site 436717003452 FMN binding site [chemical binding]; other site 436717003453 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 436717003454 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 436717003455 putative active site [active] 436717003456 putative metal binding site [ion binding]; other site 436717003457 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 436717003458 substrate binding site [chemical binding]; other site 436717003459 glutaminyl-tRNA synthetase; Provisional; Region: PRK05347 436717003460 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 436717003461 active site 436717003462 HIGH motif; other site 436717003463 nucleotide binding site [chemical binding]; other site 436717003464 catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807 436717003465 KMSKS motif; other site 436717003466 tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950 436717003467 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 436717003468 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 436717003469 catalytic triad [active] 436717003470 Ethanolamine ammonia-lyase light chain (EutC); Region: EutC; cl01762 436717003471 ethanolamine ammonia lyase large subunit; Provisional; Region: PRK15067 436717003472 Ethanolamine ammonia lyase large subunit (EutB); Region: EutB; cl09205 436717003473 ethanolamine permease; Region: 2A0305; TIGR00908 436717003474 Transmembrane amino acid transporter protein; Region: Aa_trans; cl00524 436717003475 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 436717003476 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 436717003477 NAD(P) binding site [chemical binding]; other site 436717003478 catalytic residues [active] 436717003479 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 436717003480 DNA-binding transcriptional activator of the SARP family [Signal transduction mechanisms]; Region: DnrI; COG3629 436717003481 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cl00209 436717003482 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 436717003483 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 436717003484 Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176 436717003485 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 436717003486 dimer interface [polypeptide binding]; other site 436717003487 active site 436717003488 metal binding site [ion binding]; metal-binding site 436717003489 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 436717003490 PIF1-like helicase; Region: PIF1; pfam05970 436717003491 Walker A motif; other site 436717003492 ATP binding site [chemical binding]; other site 436717003493 Walker B motif; other site 436717003494 exonuclease V subunit alpha; Provisional; Region: recD; PRK10875 436717003495 5-carboxymethyl-2-hydroxymuconate isomerase (CHMI) is a trimeric enzyme catalyzing the isomerization of the unsaturated ketone 5-(carboxymethyl)-2-hydroxymuconate to 5-(carboxymethyl)-2-oxo-3-hexene-1,6-dionate. This is one step in the...; Region: CHMI; cd00580 436717003496 putative substrate binding pocket [chemical binding]; other site 436717003497 trimer interface [polypeptide binding]; other site 436717003498 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 436717003499 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 436717003500 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; cl01368 436717003501 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 436717003502 substrate binding site [chemical binding]; other site 436717003503 multimerization interface [polypeptide binding]; other site 436717003504 ATP binding site [chemical binding]; other site 436717003505 aminopeptidase N; Provisional; Region: pepN; PRK14015 436717003506 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_1; cd09600 436717003507 active site 436717003508 Zn binding site [ion binding]; other site 436717003509 Spore Coat Protein U domain; Region: SCPU; cl02253 436717003510 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 436717003511 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 436717003512 pilin outer membrane usher protein SafC; Provisional; Region: PRK15223; cl14650 436717003513 Spore Coat Protein U domain; Region: SCPU; cl02253 436717003514 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 436717003515 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 436717003516 C-terminal domain interface [polypeptide binding]; other site 436717003517 GSH binding site (G-site) [chemical binding]; other site 436717003518 dimer interface [polypeptide binding]; other site 436717003519 Glutathione S-transferase (GST) family, C-terminal alpha helical domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and...; Region: GST_C_family; cd00299 436717003520 substrate binding pocket (H-site) [chemical binding]; other site 436717003521 N-terminal domain interface [polypeptide binding]; other site 436717003522 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 436717003523 NAD(P) binding site [chemical binding]; other site 436717003524 active site 436717003525 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 436717003526 active site 436717003527 Chorismate mutase type II; Region: CM_2; cl00693 436717003528 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 436717003529 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 436717003530 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 436717003531 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 436717003532 catalytic triad [active] 436717003533 Polysaccharide pyruvyl transferase family protein [Cell wall/membrane/envelope biogenesis]; Region: WcaK; cl09156 436717003534 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 436717003535 CoenzymeA binding site [chemical binding]; other site 436717003536 subunit interaction site [polypeptide binding]; other site 436717003537 PHB binding site; other site 436717003538 Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737 436717003539 catalytic residues [active] 436717003540 Uncharacterized conserved protein [Function unknown]; Region: COG2128 436717003541 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 436717003542 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 436717003543 Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072 436717003544 Transcriptional regulator [Transcription]; Region: LysR; COG0583 436717003545 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 436717003546 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 436717003547 dimerization interface [polypeptide binding]; other site 436717003548 Bacterial OB fold (BOF) protein; Region: BOF; cl01196 436717003549 bifunctional argininosuccinate lyase/N-acetylglutamate synthase; Provisional; Region: PRK12308 436717003550 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 436717003551 Coenzyme A binding pocket [chemical binding]; other site 436717003552 Surface antigen; Region: Surface_Ag_2; cl01155 436717003553 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 436717003554 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 436717003555 Walker A/P-loop; other site 436717003556 ATP binding site [chemical binding]; other site 436717003557 Q-loop/lid; other site 436717003558 ABC transporter signature motif; other site 436717003559 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by...; Region: ABCF_EF-3; cd03221 436717003560 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by...; Region: ABCF_EF-3; cd03221 436717003561 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 436717003562 Ligand Binding Site [chemical binding]; other site 436717003563 RDD family; Region: RDD; cl00746 436717003564 Sulfate transporter family; Region: Sulfate_transp; cl00967 436717003565 Uncharacterized protein involved in benzoate metabolism [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BenE; COG3135 436717003566 leucine-responsive transcriptional regulator; Provisional; Region: PRK11169 436717003567 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 436717003568 LysE type translocator; Region: LysE; cl00565 436717003569 transaldolase-like protein; Provisional; Region: PTZ00411 436717003570 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 436717003571 active site 436717003572 dimer interface [polypeptide binding]; other site 436717003573 catalytic residue [active] 436717003574 Transcriptional regulator [Transcription]; Region: LysR; COG0583 436717003575 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 436717003576 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 436717003577 dimerization interface [polypeptide binding]; other site 436717003578 Bacterial Transmembrane Pair family; Region: BTP; pfam05232 436717003579 Bacterial Transmembrane Pair family; Region: BTP; pfam05232 436717003580 acetyl-CoA acetyltransferase; Provisional; Region: PRK09268 436717003581 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 436717003582 dimer interface [polypeptide binding]; other site 436717003583 active site 436717003584 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08261 436717003585 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 436717003586 NAD(P) binding site [chemical binding]; other site 436717003587 active site 436717003588 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 436717003589 active site 2 [active] 436717003590 active site 1 [active] 436717003591 Beta-lactamase; Region: Beta-lactamase; cl01009 436717003592 TetR family transcriptional regulator; Provisional; Region: PRK14996 436717003593 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 436717003594 methyl viologen resistance protein SmvA; Provisional; Region: PRK14995 436717003595 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 436717003596 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families...; Region: ZnMc; cl00064 436717003597 active site 436717003598 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14960 436717003599 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 436717003600 Walker A motif; other site 436717003601 ATP binding site [chemical binding]; other site 436717003602 Walker B motif; other site 436717003603 arginine finger; other site 436717003604 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 436717003605 Pseudomonas-type; Region: PC_PLC; TIGR03396 436717003606 Phosphoesterase family; Region: Phosphoesterase; cl10627 436717003607 Domain of unknown function (DUF756); Region: DUF756; pfam05506 436717003608 Domain of unknown function (DUF756); Region: DUF756; pfam05506 436717003609 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active...; Region: 4HBT; cd00586 436717003610 active site 436717003611 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 436717003612 5-hydroxyvalerate dehydrogenase (HVD) catalyzes the oxidation of 5-hydroxyvalerate to 5-oxovalerate with NAD+ as cofactor; Region: HVD; cd08193 436717003613 putative active site [active] 436717003614 metal binding site [ion binding]; metal-binding site 436717003615 Fels-1 Prophage Protein-like; Region: Fels1; pfam05666 436717003616 Fels-1 Prophage Protein-like; Region: Fels1; pfam05666 436717003617 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 436717003618 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 436717003619 Low molecular weight phosphatase family; Region: LMWPc; cd00115 436717003620 Active site [active] 436717003621 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK00046 436717003622 FAD binding domain; Region: FAD_binding_4; pfam01565 436717003623 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 436717003624 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 436717003625 putative active site [active] 436717003626 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 436717003627 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 436717003628 Choloylglycine hydrolase (CGH) is a bile salt-modifying enzyme that hydrolyzes non-peptide carbon-nitrogen bonds in choloylglycine and choloyltaurine, both of which are present in bile. CGH is present in a number of probiotic microbial organisms that...; Region: Ntn_CGH; cd01902 436717003629 Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275 436717003630 Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069 436717003631 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant...; Region: GltS_FMN; cd02808 436717003632 active site 436717003633 FMN binding site [chemical binding]; other site 436717003634 substrate binding site [chemical binding]; other site 436717003635 3Fe-4S cluster binding site [ion binding]; other site 436717003636 DNA-binding transcriptional regulator AraC; Provisional; Region: PRK10572 436717003637 Spore Coat Protein U domain; Region: SCPU; cl02253 436717003638 long polar fimbrial chaperone LpfB; Provisional; Region: PRK15208 436717003639 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 436717003640 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 436717003641 pilin outer membrane usher protein SafC; Provisional; Region: PRK15223; cl14650 436717003642 Spore Coat Protein U domain; Region: SCPU; cl02253 436717003643 putative 3-phenylpropionic acid transporter; Provisional; Region: PRK11128 436717003644 MFS_1 like family; Region: MFS_1_like; pfam12832 436717003645 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 436717003646 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 436717003647 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 436717003648 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 436717003649 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 436717003650 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 436717003651 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase...; Region: biotinyl_domain; cd06850 436717003652 carboxyltransferase (CT) interaction site; other site 436717003653 biotinylation site [posttranslational modification]; other site 436717003654 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 436717003655 trimer interface [polypeptide binding]; other site 436717003656 active site 436717003657 dimer interface [polypeptide binding]; other site 436717003658 DNA polymerase V subunit UmuC; Reviewed; Region: umuC; PRK03609 436717003659 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 436717003660 active site 436717003661 DNA binding site [nucleotide binding] 436717003662 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 436717003663 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 436717003664 N-terminal plug; other site 436717003665 ligand-binding site [chemical binding]; other site 436717003666 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase [Carbohydrate transport and metabolism]; Region: HpcH; COG3836 436717003667 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 436717003668 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 436717003669 IucA / IucC family; Region: IucA_IucC; pfam04183 436717003670 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 436717003671 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 436717003672 IucA / IucC family; Region: IucA_IucC; pfam04183 436717003673 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 436717003674 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 436717003675 drug efflux system protein MdtG; Provisional; Region: PRK09874 436717003676 putative substrate translocation pore; other site 436717003677 IucA / IucC family; Region: IucA_IucC; pfam04183 436717003678 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 436717003679 2,3-diaminopropionate biosynthesis protein SbnB; Region: dehyd_SbnB_fam; TIGR03944 436717003680 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 436717003681 2,3-diaminopropionate biosynthesis protein SbnA; Region: PLP_SbnA_fam; TIGR03945 436717003682 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine...; Region: CBS_like; cd01561 436717003683 dimer interface [polypeptide binding]; other site 436717003684 pyridoxal 5'-phosphate binding site [chemical binding]; other site 436717003685 catalytic residue [active] 436717003686 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 436717003687 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 436717003688 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 436717003689 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 436717003690 active site 436717003691 phosphorylation site [posttranslational modification] 436717003692 intermolecular recognition site; other site 436717003693 dimerization interface [polypeptide binding]; other site 436717003694 ANTAR domain; Region: ANTAR; pfam03861 436717003695 nitrite reductase subunit NirD; Provisional; Region: PRK14989 436717003696 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 436717003697 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 436717003698 Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain...; Region: Rieske_NirD; cd03529 436717003699 NAD(P)H-nitrite reductase [Energy production and conversion]; Region: NirB; COG1251 436717003700 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 436717003701 NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol oxidation via a membrane-anchored...; Region: MopB_Nitrate-R-NapA-like; cd02754 436717003702 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 436717003703 [4Fe-4S] binding site [ion binding]; other site 436717003704 molybdopterin cofactor binding site; other site 436717003705 NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol oxidation via a membrane-anchored...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 436717003706 molybdopterin cofactor binding site; other site 436717003707 NAD(P)H-nitrite reductase [Energy production and conversion]; Region: NirB; COG1251 436717003708 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; cl01093 436717003709 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 436717003710 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 436717003711 GTP binding site [chemical binding]; other site 436717003712 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 436717003713 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and tungsten-...; Region: Molybdopterin-Binding; cl09928 436717003714 molybdopterin cofactor binding site; other site 436717003715 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and tungsten-...; Region: Molybdopterin-Binding; cl09928 436717003716 The MopB_CT_1 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. This CD is of the...; Region: MopB_CT_1; cd02782 436717003717 putative molybdopterin cofactor binding site; other site 436717003718 molybdenum cofactor biosynthesis protein A, bacterial; Region: moaA; TIGR02666 436717003719 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 436717003720 FeS/SAM binding site; other site 436717003721 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 436717003722 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 436717003723 MoaE homodimer interface [polypeptide binding]; other site 436717003724 MoaD interaction [polypeptide binding]; other site 436717003725 active site residues [active] 436717003726 bifunctional molybdenum cofactor biosynthesis protein MoaC/MogA; Provisional; Region: moaC; PRK03604 436717003727 MoaC family. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine derivative to the...; Region: MoaC; cl00242 436717003728 trimer interface [polypeptide binding]; other site 436717003729 dimer interface [polypeptide binding]; other site 436717003730 putative active site [active] 436717003731 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea...; Region: MogA_MoaB; cd00886 436717003732 MPT binding site; other site 436717003733 trimer interface [polypeptide binding]; other site 436717003734 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 436717003735 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 436717003736 dimer interface [polypeptide binding]; other site 436717003737 putative functional site; other site 436717003738 putative MPT binding site; other site 436717003739 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 436717003740 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 436717003741 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 436717003742 DNA-binding site [nucleotide binding]; DNA binding site 436717003743 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 436717003744 pyridoxal 5'-phosphate binding site [chemical binding]; other site 436717003745 homodimer interface [polypeptide binding]; other site 436717003746 catalytic residue [active] 436717003747 EamA-like transporter family; Region: EamA; cl01037 436717003748 DsrC like protein; Region: DsrC; cl01101 436717003749 DsrE/DsrF-like family; Region: DrsE; cl00672 436717003750 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 436717003751 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 436717003752 NAD(P) binding site [chemical binding]; other site 436717003753 active site 436717003754 fumarate hydratase; Reviewed; Region: fumC; PRK00485 436717003755 Class II fumarases; Region: Fumarase_classII; cd01362 436717003756 active site 436717003757 tetramer interface [polypeptide binding]; other site 436717003758 Isochorismatase family; Region: Isochorismatase; pfam00857 436717003759 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 436717003760 catalytic triad [active] 436717003761 conserved cis-peptide bond; other site 436717003762 D-amino acid dehydrogenase small subunit; Provisional; Region: PRK12409 436717003763 Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl14881 436717003764 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid...; Region: MECDP_synthase; cd00554 436717003765 homotrimer interaction site [polypeptide binding]; other site 436717003766 zinc binding site [ion binding]; other site 436717003767 CDP-binding sites; other site 436717003768 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr (; Region: PTPc; cl00053 436717003769 ornithine carbamoyltransferase; Provisional; Region: PRK00779 436717003770 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 436717003771 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 436717003772 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 436717003773 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 436717003774 nitrogen regulation protein NR(I); Region: ntrC; TIGR01818 436717003775 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 436717003776 active site 436717003777 phosphorylation site [posttranslational modification] 436717003778 intermolecular recognition site; other site 436717003779 dimerization interface [polypeptide binding]; other site 436717003780 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 436717003781 Walker A motif; other site 436717003782 ATP binding site [chemical binding]; other site 436717003783 Walker B motif; other site 436717003784 arginine finger; other site 436717003785 Bacterial regulatory protein, Fis family; Region: HTH_8; cl01091 436717003786 potential frameshift: common BLAST hit: gi|215483165|ref|YP_002325372.1| Nitrogen regulation protein ntrB 436717003787 ribosomal protein S12 methylthiotransferase; Provisional; Region: rimO; PRK14862 436717003788 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 436717003789 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 436717003790 FeS/SAM binding site; other site 436717003791 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control...; Region: AAK_UMPK-PyrH-Ec; cd04254 436717003792 putative nucleotide binding site [chemical binding]; other site 436717003793 uridine monophosphate binding site [chemical binding]; other site 436717003794 homohexameric interface [polypeptide binding]; other site 436717003795 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are 'recycled' and ready for another round of...; Region: RRF; cd00520 436717003796 hinge region; other site 436717003797 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 436717003798 catalytic residue [active] 436717003799 putative FPP diphosphate binding site; other site 436717003800 putative FPP binding hydrophobic cleft; other site 436717003801 dimer interface [polypeptide binding]; other site 436717003802 putative IPP diphosphate binding site; other site 436717003803 Cytidylyltransferase family; Region: CTP_transf_1; cl00347 436717003804 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 436717003805 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 436717003806 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 436717003807 zinc metallopeptidase RseP; Provisional; Region: PRK10779 436717003808 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 436717003809 active site 436717003810 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most...; Region: PDZ_metalloprotease; cd00989 436717003811 protein binding site [polypeptide binding]; other site 436717003812 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most...; Region: PDZ_metalloprotease; cd00989 436717003813 protein binding site [polypeptide binding]; other site 436717003814 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 436717003815 putative substrate binding region [chemical binding]; other site 436717003816 outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303 436717003817 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520 436717003818 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520 436717003819 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520 436717003820 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520 436717003821 Surface antigen; Region: Bac_surface_Ag; cl03097 436717003822 Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: HlpA; COG2825 436717003823 Outer membrane protein (OmpH-like); Region: OmpH; cl08146 436717003824 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 436717003825 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 436717003826 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2,3-...; Region: LbH_LpxD; cd03352 436717003827 trimer interface [polypeptide binding]; other site 436717003828 active site 436717003829 UDP-GlcNAc binding site [chemical binding]; other site 436717003830 lipid binding site [chemical binding]; lipid-binding site 436717003831 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 436717003832 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 436717003833 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A...; Region: LbH_UDP-GlcNAc_AT; cd03351 436717003834 active site 436717003835 chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169 436717003836 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 436717003837 RecX family; Region: RecX; cl00936 436717003838 recombinase A; Provisional; Region: recA; PRK09354 436717003839 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 436717003840 hexamer interface [polypeptide binding]; other site 436717003841 Walker A motif; other site 436717003842 ATP binding site [chemical binding]; other site 436717003843 Walker B motif; other site 436717003844 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 436717003845 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 436717003846 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 436717003847 motif II; other site 436717003848 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 436717003849 Phage integrase family; Region: Phage_integrase; pfam00589 436717003850 active site 436717003851 Int/Topo IB signature motif; other site 436717003852 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 436717003853 exodeoxyribonuclease X; Provisional; Region: PRK07983 436717003854 active site 436717003855 substrate binding site [chemical binding]; other site 436717003856 catalytic site [active] 436717003857 Protein of unknown function (DUF3820); Region: DUF3820; cl01411 436717003858 Uncharacterized conserved protein (DUF2303); Region: DUF2303; cl02338 436717003859 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (...; Region: S24_LexA-like; cd06529 436717003860 Catalytic site [active] 436717003861 RNA polymerase sigma-70 factor, sigma-B/F/G subfamily; Region: SigBFG; TIGR02980 436717003862 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 436717003863 cofactor binding site; other site 436717003864 DNA binding site [nucleotide binding] 436717003865 substrate interaction site [chemical binding]; other site 436717003866 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 436717003867 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 436717003868 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 436717003869 Walker A motif; other site 436717003870 ATP binding site [chemical binding]; other site 436717003871 Walker B motif; other site 436717003872 arginine finger; other site 436717003873 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 436717003874 Endodeoxyribonuclease RusA; Region: RusA; cl01885 436717003875 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl09100 436717003876 Mu-like prophage protein [General function prediction only]; Region: COG3941; cl09192 436717003877 Arc-like DNA binding domain; Region: Arc; pfam03869 436717003878 P22_AR N-terminal domain; Region: P22_AR_N; pfam10547 436717003879 ORF6C domain; Region: ORF6C; pfam10552 436717003880 Protein of unknown function (DUF2971); Region: DUF2971; pfam11185 436717003881 glutathione reductase; Validated; Region: PRK06116 436717003882 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 436717003883 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 436717003884 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 436717003885 Major Facilitator Superfamily; Region: MFS_1; pfam07690 436717003886 putative substrate translocation pore; other site 436717003887 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 436717003888 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 436717003889 OsmC-like protein; Region: OsmC; cl00767 436717003890 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 436717003891 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 436717003892 classical (c) SDRs; Region: SDR_c; cd05233 436717003893 NAD(P) binding site [chemical binding]; other site 436717003894 active site 436717003895 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 436717003896 catalytic residues [active] 436717003897 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 436717003898 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 436717003899 FMN binding site [chemical binding]; other site 436717003900 active site 436717003901 substrate binding site [chemical binding]; other site 436717003902 catalytic residue [active] 436717003903 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 436717003904 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 436717003905 catalytic residues [active] 436717003906 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 436717003907 Oligogalacturonate-specific porin protein (KdgM); Region: KdgM; cl11629 436717003908 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 436717003909 putative substrate translocation pore; other site 436717003910 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 436717003911 transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393 436717003912 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 436717003913 conserved cys residue [active] 436717003914 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 436717003915 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 436717003916 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 436717003917 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562 436717003918 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16...; Region: OM_channels; cl00284 436717003919 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16...; Region: OM_channels; cl00284 436717003920 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 436717003921 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 436717003922 N-terminal plug; other site 436717003923 ligand-binding site [chemical binding]; other site 436717003924 Uncharacterized lipoprotein NlpE involved in copper resistance; Region: NlpE; cl01138 436717003925 Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; cl10713 436717003926 Phage antirepressor protein KilAC domain; Region: ANT; cl01462 436717003927 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a...; Region: Hint; cl12032 436717003928 Hom_end-associated Hint; Region: Hom_end_hint; pfam05203 436717003929 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl09100 436717003930 HipA-like N-terminal domain; Region: HipA_N; pfam07805 436717003931 HipA-like C-terminal domain; Region: HipA_C; pfam07804 436717003932 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 436717003933 Domain of unknown function (DUF1983); Region: DUF1983; pfam09327 436717003934 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 436717003935 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl14882 436717003936 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 436717003937 NlpC/P60 family; Region: NLPC_P60; cl11438 436717003938 extracellular lipase, Pla-1/cef family; Region: lipase_Pla1_cef; TIGR03502 436717003939 Uncharacterized conserved protein [Function unknown]; Region: COG4104 436717003940 DNA polymerase V subunit UmuC; Reviewed; Region: umuC; PRK03609 436717003941 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 436717003942 active site 436717003943 DNA binding site [nucleotide binding] 436717003944 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (...; Region: S24_LexA-like; cd06529 436717003945 Catalytic site [active] 436717003946 Uncharacterised ACR, COG2135; Region: DUF159; cl03646 436717003947 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 436717003948 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 436717003949 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 436717003950 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 436717003951 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 436717003952 kynureninase; Region: kynureninase; TIGR01814 436717003953 Transmembrane amino acid transporter protein; Region: Aa_trans; cl00524 436717003954 ethanolamine permease; Region: 2A0305; TIGR00908 436717003955 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 436717003956 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 436717003957 Peptidase S8 family domain in ProteinaseK-like proteins; Region: Peptidases_S8_PCSK9_ProteinaseK_like; cd04077 436717003958 calcium binding site 2 [ion binding]; other site 436717003959 active site 436717003960 catalytic triad [active] 436717003961 calcium binding site 1 [ion binding]; other site 436717003962 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 436717003963 Bacitracin resistance protein BacA; Region: BacA; cl00858 436717003964 Sulfate transporter family; Region: Sulfate_transp; cl00967 436717003965 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 436717003966 Uncharacterised ACR, COG2135; Region: DUF159; cl03646 436717003967 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 436717003968 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 436717003969 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 436717003970 Ligand Binding Site [chemical binding]; other site 436717003971 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 436717003972 PAS fold; Region: PAS_4; pfam08448 436717003973 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 436717003974 metal binding site [ion binding]; metal-binding site 436717003975 active site 436717003976 I-site; other site 436717003977 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 436717003978 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 436717003979 PTS system fructose-specific transporter subunits IIBC; Provisional; Region: PRK10712 436717003980 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA...; Region: PTS_IIB_fructose; cd05569 436717003981 P-loop; other site 436717003982 active site 436717003983 phosphorylation site [posttranslational modification] 436717003984 Phosphotransferase system, EIIC; Region: PTS_EIIC; cl00557 436717003985 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 436717003986 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 436717003987 putative substrate binding site [chemical binding]; other site 436717003988 putative ATP binding site [chemical binding]; other site 436717003989 bifunctional PTS system fructose-specific transporter subunit IIA/HPr protein; Provisional; Region: PRK11109 436717003990 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 436717003991 active site 436717003992 phosphorylation site [posttranslational modification] 436717003993 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cl00163 436717003994 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 436717003995 dimerization domain swap beta strand [polypeptide binding]; other site 436717003996 regulatory protein interface [polypeptide binding]; other site 436717003997 active site 436717003998 regulatory phosphorylation site [posttranslational modification]; other site 436717003999 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 436717004000 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 436717004001 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 436717004002 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 436717004003 Predicted alpha/beta hydrolase [General function prediction only]; Region: COG4757 436717004004 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 436717004005 Domain of unknown function (DUF336); Region: DUF336; cl01249 436717004006 Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547 436717004007 methionine aminopeptidase; Reviewed; Region: PRK07281 436717004008 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 436717004009 active site 436717004010 LysR family transcriptional regulator; Provisional; Region: PRK14997 436717004011 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 436717004012 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_4; cd08473 436717004013 putative effector binding pocket; other site 436717004014 putative dimerization interface [polypeptide binding]; other site 436717004015 Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028 436717004016 putative GSH binding site [chemical binding]; other site 436717004017 catalytic residues [active] 436717004018 acetylornithine aminotransferase; Provisional; Region: PRK02627 436717004019 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase...; Region: OAT_like; cd00610 436717004020 inhibitor-cofactor binding pocket; inhibition site 436717004021 pyridoxal 5'-phosphate binding site [chemical binding]; other site 436717004022 catalytic residue [active] 436717004023 FOG: CBS domain [General function prediction only]; Region: COG0517 436717004024 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-...; Region: CBS_pair_10; cd04623 436717004025 Protein of unknown function (DUF2750); Region: DUF2750; pfam11042 436717004026 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 436717004027 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 436717004028 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 436717004029 P loop; other site 436717004030 GTP binding site [chemical binding]; other site 436717004031 Nitroreductase-like family 4. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_4; cd02140 436717004032 dimer interface [polypeptide binding]; other site 436717004033 FMN binding site [chemical binding]; other site 436717004034 Uncharacterized protein conserved in bacteria (DUF2057); Region: DUF2057; cl11437 436717004035 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 436717004036 Cyd operon protein YbgE (Cyd_oper_YbgE); Region: Cyd_oper_YbgE; cl11451 436717004037 Membrane bound YbgT-like protein; Region: YbgT_YccB; cl02039 436717004038 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 436717004039 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 436717004040 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562 436717004041 Protein of unknown function (DUF1449); Region: DUF1449; pfam07290 436717004042 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1)...; Region: Rieske; cd03467 436717004043 iron-sulfur cluster [ion binding]; other site 436717004044 [2Fe-2S] cluster binding site [ion binding]; other site 436717004045 Adenosine kinase (AK) catalyzes the phosphorylation of ribofuranosyl-containing nucleoside analogues at the 5'-hydroxyl using ATP or GTP as the phosphate donor.The physiological function of AK is associated with the regulation of extracellular...; Region: adenosine_kinase; cd01168 436717004046 substrate binding site [chemical binding]; other site 436717004047 ATP binding site [chemical binding]; other site 436717004048 potential frameshift: common BLAST hit: gi|184158352|ref|YP_001846691.1| ferrichrome-iron receptor protein 436717004049 Predicted Zn-dependent peptidases, insulinase-like [General function prediction only]; Region: COG1026 436717004050 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 436717004051 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 436717004052 Peptidase M16C associated; Region: M16C_assoc; pfam08367 436717004053 The outer membrane phospholipase A (OMPLA) is an integral membrane enzyme that catalyses the hydrolysis of acylester bonds in phospholipids using calcium as a cofactor. The enzyme has a fold of transmembrane beta-barrels and is widespread among Gram-...; Region: OMPLA; cd00541 436717004054 dimerization interface [polypeptide binding]; other site 436717004055 substrate binding site [chemical binding]; other site 436717004056 active site 436717004057 calcium binding site [ion binding]; other site 436717004058 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 436717004059 Cation transport protein; Region: TrkH; cl10514 436717004060 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 436717004061 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 436717004062 threonine dehydratase; Reviewed; Region: PRK09224 436717004063 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 436717004064 tetramer interface [polypeptide binding]; other site 436717004065 pyridoxal 5'-phosphate binding site [chemical binding]; other site 436717004066 catalytic residue [active] 436717004067 First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906 436717004068 putative Ile/Val binding site [chemical binding]; other site 436717004069 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 436717004070 putative Ile/Val binding site [chemical binding]; other site 436717004071 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 436717004072 tetramer (dimer of dimers) interface [polypeptide binding]; other site 436717004073 active site 436717004074 dimer interface [polypeptide binding]; other site 436717004075 Protein of unknown function DUF45; Region: DUF45; cl00636 436717004076 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 436717004077 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 436717004078 Semialdehyde dehydrogenase, dimerisation domain; Region: Semialdhyde_dhC; pfam02774 436717004079 ATP-dependent Clp protease adaptor protein ClpS; Region: ClpS; cl00933 436717004080 ATP-dependent Clp protease ATP-binding subunit clpA; Region: ClpA; TIGR02639 436717004081 Clp amino terminal domain; Region: Clp_N; pfam02861 436717004082 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 436717004083 Walker A motif; other site 436717004084 ATP binding site [chemical binding]; other site 436717004085 Walker B motif; other site 436717004086 arginine finger; other site 436717004087 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 436717004088 Walker A motif; other site 436717004089 ATP binding site [chemical binding]; other site 436717004090 Walker B motif; other site 436717004091 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 436717004092 Uncharacterised BCR, YnfA/UPF0060 family; Region: UPF0060; cl00757 436717004093 NeuB family; Region: NeuB; cl00496 436717004094 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 436717004095 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 436717004096 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 436717004097 Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400 436717004098 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 436717004099 2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930 436717004100 active site 436717004101 FMN binding site [chemical binding]; other site 436717004102 2,4-decadienoyl-CoA binding site; other site 436717004103 catalytic residue [active] 436717004104 4Fe-4S cluster binding site [ion binding]; other site 436717004105 dihydropyrimidine dehydrogenase subunit A; Provisional; Region: PRK11749 436717004106 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 436717004107 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 436717004108 FeeB and similar esterases/lipases. FeeA and FeeB are part of a biosynthetic gene cluster and may participate in the biosynthesis of long-chain N-acyltyrosines by providing saturated and unsaturated fatty acids, which it turn are loaded onto the acyl...; Region: FeeA_FeeB_like; cd01836 436717004109 active site 436717004110 catalytic triad [active] 436717004111 oxyanion hole [active] 436717004112 hydrolase; Region: PLN02511 436717004113 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687 436717004114 Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118 436717004115 CTP synthetase; Validated; Region: pyrG; PRK05380 436717004116 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer...; Region: CTGs; cd03113 436717004117 Catalytic site [active] 436717004118 Active site [active] 436717004119 UTP binding site [chemical binding]; other site 436717004120 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 436717004121 active site 436717004122 putative oxyanion hole; other site 436717004123 catalytic triad [active] 436717004124 NeuB family; Region: NeuB; cl00496 436717004125 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 436717004126 enolase; Provisional; Region: eno; PRK00077 436717004127 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 436717004128 dimer interface [polypeptide binding]; other site 436717004129 metal binding site [ion binding]; metal-binding site 436717004130 substrate binding pocket [chemical binding]; other site 436717004131 Protein of unknown function (DUF421); Region: DUF421; cl00990 436717004132 Outer membrane receptor for ferric coprogen and ferric-rhodotorulic acid [Inorganic ion transport and metabolism]; Region: FhuE; COG4773 436717004133 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 436717004134 N-terminal plug; other site 436717004135 ligand-binding site [chemical binding]; other site 436717004136 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 436717004137 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 436717004138 Coenzyme A binding pocket [chemical binding]; other site 436717004139 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 436717004140 Septum formation initiator; Region: DivIC; cl11433 436717004141 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 436717004142 substrate binding site [chemical binding]; other site 436717004143 dimer interface [polypeptide binding]; other site 436717004144 Coenzyme A transferase; Region: CoA_trans; cl00773 436717004145 Coenzyme A transferase; Region: CoA_trans; cl00773 436717004146 beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050 436717004147 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 436717004148 dimer interface [polypeptide binding]; other site 436717004149 active site 436717004150 3-carboxy-cis,cis-muconate cycloisomerase; Provisional; Region: PRK09053 436717004151 prokaryotic 3-carboxy-cis,cis-muconate cycloisomerase (CMLE)_like; Region: pCLME; cd01597 436717004152 tetramer interface [polypeptide binding]; other site 436717004153 active site 436717004154 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 436717004155 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 436717004156 benzoate transport; Region: 2A0115; TIGR00895 436717004157 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 436717004158 putative substrate translocation pore; other site 436717004159 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 436717004160 Protocatechuate 3,4-dioxygenase (3,4-PCD) , beta subunit. 3,4-PCD catalyzes the oxidative ring cleavage of 3,4-dihydroxybenzoate to produce beta-carboxy-cis,cis-muconate. 3,4-PCDs are large aggregates of 12 protomers, each composed of an alpha- and...; Region: 3,4-PCD_beta; cd03464 436717004161 multimer interface [polypeptide binding]; other site 436717004162 heterodimer interface [polypeptide binding]; other site 436717004163 protocatechuate 3,4-dioxygenase, beta subunit; Region: protocat_beta; TIGR02422 436717004164 active site 436717004165 Protocatechuate 3,4-dioxygenase beta subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PcaH; COG3485 436717004166 Protocatechuate 3,4-dioxygenase (3,4-PCD) , alpha subunit. 3,4-PCD catalyzes the oxidative ring cleavage of 3,4-dihydroxybenzoate to produce beta-carboxy-cis,cis-muconate. 3,4-PCDs are large aggregates of 12 protomers, each composed of an alpha- and...; Region: 3,4-PCD_alpha; cd03463 436717004167 heterodimer interface [polypeptide binding]; other site 436717004168 active site 436717004169 Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502 436717004170 3-dehydroquinate dehydratase, type I; Region: aroD; TIGR01093 436717004171 active site 436717004172 catalytic residue [active] 436717004173 dimer interface [polypeptide binding]; other site 436717004174 Nitrous oxidase accessory protein [Inorganic ion transport and metabolism]; Region: NosD; COG3420 436717004175 Carbohydrate-selective porin [Cell envelope biogenesis, outer membrane]; Region: OprB; COG3659 436717004176 Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966 436717004177 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 436717004178 membrane-bound PQQ-dependent dehydrogenase, glucose/quinate/shikimate family; Region: PQQ_membr_DH; TIGR03074 436717004179 Dehydrogenases with pyrrolo-quinoline quinone (PQQ) as cofactor, like ethanol, methanol, and membrane bound glucose dehydrogenases. The alignment model contains an 8-bladed beta-propeller; Region: PQQ_DH; cl11493 436717004180 Trp docking motif; other site 436717004181 active site 436717004182 Dehydrogenases with pyrrolo-quinoline quinone (PQQ) as cofactor, like ethanol, methanol, and membrane bound glucose dehydrogenases. The alignment model contains an 8-bladed beta-propeller; Region: PQQ_DH; cl11493 436717004183 'Velcro' closure; other site 436717004184 YeeE/YedE family (DUF395); Region: DUF395; cl01018 436717004185 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 436717004186 beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Region: pcaR_pcaU; TIGR02431 436717004187 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 436717004188 Bacterial transcriptional regulator; Region: IclR; pfam01614 436717004189 Transcriptional regulator [Transcription]; Region: LysR; COG0583 436717004190 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 436717004191 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 436717004192 substrate binding pocket [chemical binding]; other site 436717004193 dimerization interface [polypeptide binding]; other site 436717004194 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 436717004195 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 436717004196 active site 436717004197 Predicted aminoglycoside phosphotransferase [General function prediction only]; Region: COG3173 436717004198 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: ACAD10_11_like; cd05154 436717004199 putative active site [active] 436717004200 putative substrate binding site [chemical binding]; other site 436717004201 ATP binding site [chemical binding]; other site 436717004202 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 436717004203 catalytic core [active] 436717004204 short chain dehydrogenase; Provisional; Region: PRK08251 436717004205 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 436717004206 NAD(P) binding site [chemical binding]; other site 436717004207 active site 436717004208 outer membrane porin, OprD family; Region: OprD; pfam03573 436717004209 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 436717004210 Major Facilitator Superfamily; Region: MFS_1; pfam07690 436717004211 putative substrate translocation pore; other site 436717004212 Transcriptional regulators [Transcription]; Region: MarR; COG1846 436717004213 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 436717004214 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl11426 436717004215 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 436717004216 active site 436717004217 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 436717004218 benzoate 1,2-dioxygenase, large subunit; Region: benzo_1_2_benA; TIGR03229 436717004219 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 436717004220 [2Fe-2S] cluster binding site [ion binding]; other site 436717004221 C-terminal catalytic domain of the oxygenase alpha subunit of Pseudomonas resinovorans strain CA10 anthranilate 1,2-dioxygenase and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_AntDO-like; cd08879 436717004222 putative alpha subunit interface [polypeptide binding]; other site 436717004223 putative active site [active] 436717004224 putative substrate binding site [chemical binding]; other site 436717004225 Fe binding site [ion binding]; other site 436717004226 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 436717004227 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 436717004228 classical (c) SDRs; Region: SDR_c; cd05233 436717004229 NAD(P) binding site [chemical binding]; other site 436717004230 active site 436717004231 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 436717004232 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-...; Region: PDR_like; cd06185 436717004233 FMN-binding pocket [chemical binding]; other site 436717004234 flavin binding motif; other site 436717004235 phosphate binding motif [ion binding]; other site 436717004236 beta-alpha-beta structure motif; other site 436717004237 NAD binding pocket [chemical binding]; other site 436717004238 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 436717004239 catalytic loop [active] 436717004240 iron binding site [ion binding]; other site 436717004241 Flavin Reductases; Region: FlaRed; cl00801 436717004242 DNA-binding transcriptional activator FeaR; Provisional; Region: PRK09685 436717004243 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 436717004244 tyramine oxidase; Provisional; Region: tynA; PRK14696 436717004245 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 436717004246 Copper amine oxidase, N3 domain; Region: Cu_amine_oxidN3; pfam02728 436717004247 Copper amine oxidase, enzyme domain; Region: Cu_amine_oxid; pfam01179 436717004248 choline dehydrogenase; Validated; Region: PRK02106 436717004249 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 436717004250 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 436717004251 Escherichia coli NAD+-dependent phenylacetaldehyde dehydrogenase PadA-like; Region: ALDH_PADH_NahF; cd07113 436717004252 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 436717004253 NAD(P) binding site [chemical binding]; other site 436717004254 catalytic residues [active] 436717004255 Protein related to penicillin acylase [General function prediction only]; Region: COG2366 436717004256 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a four-...; Region: Ntn_hydrolase; cl00467 436717004257 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a four-...; Region: Ntn_hydrolase; cl00467 436717004258 active site 436717004259 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 436717004260 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 436717004261 beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050 436717004262 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 436717004263 dimer interface [polypeptide binding]; other site 436717004264 active site 436717004265 Coenzyme A transferase; Region: CoA_trans; cl00773 436717004266 Coenzyme A transferase; Region: CoA_trans; cl00773 436717004267 catechol 1,2-dioxygenase, proteobacterial; Region: catechol_proteo; TIGR02439 436717004268 Catechol 1,2 dioxygenase (1,2-CTD) catalyzes an intradiol cleavage reaction of catechol to form cis,cis-muconate. 1,2-CTDs is homodimers with one catalytic non-heme ferric ion per monomer. They belong to the aromatic dioxygenase family, a family of...; Region: 1,2-CTD; cd03460 436717004269 dimer interface [polypeptide binding]; other site 436717004270 active site 436717004271 Muconolactone delta-isomerase; Region: MIase; cl01992 436717004272 muconate and chloromuconate cycloisomerases; Region: mucon_cyclo; TIGR02534 436717004273 Muconate Lactonizing Enzyme (MLE), an homooctameric enzyme, catalyses the conversion of cis,cis-muconate (CCM) to muconolactone (ML) in the catechol branch of the beta-ketoadipate pathway. This pathway is used in soil microbes to breakdown lignin-...; Region: MLE; cd03318 436717004274 octamer interface [polypeptide binding]; other site 436717004275 active site 436717004276 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 436717004277 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 436717004278 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 436717004279 dimerization interface [polypeptide binding]; other site 436717004280 Bacterial protein of unknown function (Gcw_chp); Region: Gcw_chp; cl09901 436717004281 Transcriptional regulator [Transcription]; Region: LysR; COG0583 436717004282 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 436717004283 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 436717004284 dimerization interface [polypeptide binding]; other site 436717004285 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 436717004286 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 436717004287 dimer interface [polypeptide binding]; other site 436717004288 active site 436717004289 non-prolyl cis peptide bond; other site 436717004290 insertion regions; other site 436717004291 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and...; Region: PBPb; cd00134 436717004292 substrate binding pocket [chemical binding]; other site 436717004293 membrane-bound complex binding site; other site 436717004294 hinge residues; other site 436717004295 Cysteine dioxygenase type I; Region: CDO_I; cl02350 436717004296 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 436717004297 active site residue [active] 436717004298 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 436717004299 active site residue [active] 436717004300 Member of the Rhodanese Homology Domain superfamily, repeat 3. This CD includes putative rhodanese-related sulfurtransferases which contain 4 copies of the Rhodanese Homology Domain. This CD aligns the 3rd repeat which does not contain the putative...; Region: 4RHOD_Repeat_3; cd01534 436717004301 active site residue [active] 436717004302 Member of the Rhodanese Homology Domain superfamily, repeat 4. This CD includes putative rhodanese-related sulfurtransferases which contain 4 copies of the Rhodanese Homology Domain. This CD aligns the 4th repeat which, in general, contains the...; Region: 4RHOD_Repeat_4; cd01535 436717004303 active site residue [active] 436717004304 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 436717004305 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 436717004306 The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine. MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E...; Region: ABC_Mj1267_LivG_branched; cd03219 436717004307 Walker A/P-loop; other site 436717004308 ATP binding site [chemical binding]; other site 436717004309 Q-loop/lid; other site 436717004310 ABC transporter signature motif; other site 436717004311 Walker B; other site 436717004312 D-loop; other site 436717004313 H-loop/switch region; other site 436717004314 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 436717004315 TM-ABC transporter signature motif; other site 436717004316 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 436717004317 TM-ABC transporter signature motif; other site 436717004318 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_1; cd06334 436717004319 putative ligand binding site [chemical binding]; other site 436717004320 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 436717004321 LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids. The E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224 436717004322 Walker A/P-loop; other site 436717004323 ATP binding site [chemical binding]; other site 436717004324 Q-loop/lid; other site 436717004325 ABC transporter signature motif; other site 436717004326 Walker B; other site 436717004327 D-loop; other site 436717004328 H-loop/switch region; other site 436717004329 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 436717004330 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 436717004331 Walker A motif; other site 436717004332 ATP binding site [chemical binding]; other site 436717004333 Walker B motif; other site 436717004334 arginine finger; other site 436717004335 Bacterial regulatory protein, Fis family; Region: HTH_8; cl01091 436717004336 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 436717004337 Dibenzothiophene (DBT) desulfurization enzyme C; Region: DszC; cd01163 436717004338 Flavin binding site [chemical binding]; other site 436717004339 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 436717004340 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 436717004341 Walker A motif; other site 436717004342 ATP binding site [chemical binding]; other site 436717004343 Walker B motif; other site 436717004344 arginine finger; other site 436717004345 Bacterial regulatory protein, Fis family; Region: HTH_8; cl01091 436717004346 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 436717004347 classical (c) SDRs; Region: SDR_c; cd05233 436717004348 NAD(P) binding site [chemical binding]; other site 436717004349 active site 436717004350 beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Region: pcaR_pcaU; TIGR02431 436717004351 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 436717004352 Bacterial transcriptional regulator; Region: IclR; pfam01614 436717004353 putative succinate dehydrogenase; Reviewed; Region: PRK12842 436717004354 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 436717004355 NIPSNAP; Region: NIPSNAP; pfam07978 436717004356 benzoate transport; Region: 2A0115; TIGR00895 436717004357 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl11420 436717004358 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 436717004359 putative substrate translocation pore; other site 436717004360 Carbohydrate-selective porin [Cell envelope biogenesis, outer membrane]; Region: OprB; COG3659 436717004361 Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966 436717004362 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 436717004363 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 436717004364 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 436717004365 Transcriptional regulator [Transcription]; Region: IclR; COG1414 436717004366 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 436717004367 Bacterial transcriptional regulator; Region: IclR; pfam01614 436717004368 benzoate transport; Region: 2A0115; TIGR00895 436717004369 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 436717004370 putative substrate translocation pore; other site 436717004371 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 436717004372 shikimate 5-dehydrogenase; Provisional; Region: PRK12548 436717004373 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 436717004374 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 436717004375 shikimate binding site; other site 436717004376 NAD(P) binding site [chemical binding]; other site 436717004377 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 436717004378 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 436717004379 putative succinate dehydrogenase; Reviewed; Region: PRK12842 436717004380 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12843 436717004381 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 436717004382 NIPSNAP; Region: NIPSNAP; pfam07978 436717004383 NIPSNAP; Region: NIPSNAP; pfam07978 436717004384 Acetoacetate decarboxylase (ADC); Region: ADC; cl01919 436717004385 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 436717004386 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 436717004387 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 436717004388 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 436717004389 Old yellow enzyme (OYE)-related FMN binding domain, group 2. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_2_FMN; cd04733 436717004390 putative active site [active] 436717004391 putative FMN binding site [chemical binding]; other site 436717004392 putative substrate binding site [chemical binding]; other site 436717004393 putative catalytic residue [active] 436717004394 Uncharacterized conserved protein [Function unknown]; Region: COG3268 436717004395 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 436717004396 NAD(P) binding site [chemical binding]; other site 436717004397 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5,10-...; Region: DHFR; cl00161 436717004398 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 436717004399 potential catalytic triad [active] 436717004400 conserved cys residue [active] 436717004401 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 436717004402 DNA binding residues [nucleotide binding] 436717004403 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 436717004404 potential catalytic triad [active] 436717004405 conserved cys residue [active] 436717004406 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 436717004407 Predicted transcriptional regulator [Transcription]; Region: COG1959 436717004408 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 436717004409 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 436717004410 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 436717004411 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 436717004412 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 436717004413 Helix-turn-helix domain; Region: HTH_18; pfam12833 436717004414 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 436717004415 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 436717004416 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 436717004417 NAD(P) binding site [chemical binding]; other site 436717004418 active site 436717004419 Acetoacetate decarboxylase (ADC); Region: ADC; cl01919 436717004420 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687 436717004421 Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118 436717004422 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 436717004423 Old yellow enzyme (OYE)-related FMN binding domain, group 2. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_2_FMN; cd04733 436717004424 putative active site [active] 436717004425 putative FMN binding site [chemical binding]; other site 436717004426 putative substrate binding site [chemical binding]; other site 436717004427 putative catalytic residue [active] 436717004428 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687 436717004429 Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118 436717004430 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 436717004431 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 436717004432 putative NAD(P) binding site [chemical binding]; other site 436717004433 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 436717004434 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 436717004435 NADP binding site [chemical binding]; other site 436717004436 active site 436717004437 steroid binding site; other site 436717004438 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 436717004439 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 436717004440 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 436717004441 substrate binding site [chemical binding]; other site 436717004442 oxyanion hole (OAH) forming residues; other site 436717004443 trimer interface [polypeptide binding]; other site 436717004444 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 436717004445 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 436717004446 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 436717004447 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656 436717004448 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 436717004449 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 436717004450 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 436717004451 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 436717004452 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 436717004453 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 436717004454 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 436717004455 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 436717004456 Old yellow enzyme (OYE)-related FMN binding domain, group 2. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_2_FMN; cd04733 436717004457 putative active site [active] 436717004458 putative FMN binding site [chemical binding]; other site 436717004459 putative substrate binding site [chemical binding]; other site 436717004460 putative catalytic residue [active] 436717004461 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 436717004462 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 436717004463 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 436717004464 triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269 436717004465 NADP binding site [chemical binding]; other site 436717004466 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 436717004467 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 436717004468 Surface antigen; Region: Surface_Ag_2; cl01155 436717004469 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 436717004470 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 436717004471 Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670 436717004472 Retinal pigment epithelial membrane protein; Region: RPE65; cl10080 436717004473 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 436717004474 Transcriptional regulator [Transcription]; Region: IclR; COG1414 436717004475 Bacterial transcriptional regulator; Region: IclR; pfam01614 436717004476 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 436717004477 Major Facilitator Superfamily; Region: MFS_1; pfam07690 436717004478 putative substrate translocation pore; other site 436717004479 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 436717004480 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 436717004481 hypothetical protein; Validated; Region: PRK06201 436717004482 Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480 436717004483 Phd_YefM; Region: PhdYeFM; cl09153 436717004484 RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931 436717004485 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; cl12108 436717004486 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; cl12108 436717004487 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520 436717004488 Surface antigen; Region: Bac_surface_Ag; cl03097 436717004489 haemagglutination activity domain; Region: Haemagg_act; cl05436 436717004490 Possible hemagglutinin (DUF637); Region: DUF637; pfam04830 436717004491 SMI1 / KNR4 family; Region: SMI1_KNR4; cl01747 436717004492 Transcriptional regulator [Transcription]; Region: LysR; COG0583 436717004493 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 436717004494 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 436717004495 dimerization interface [polypeptide binding]; other site 436717004496 beta alanine--pyruvate transaminase; Provisional; Region: PRK09221 436717004497 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase...; Region: OAT_like; cd00610 436717004498 inhibitor-cofactor binding pocket; inhibition site 436717004499 pyridoxal 5'-phosphate binding site [chemical binding]; other site 436717004500 catalytic residue [active] 436717004501 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 436717004502 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 436717004503 tetrameric interface [polypeptide binding]; other site 436717004504 NAD binding site [chemical binding]; other site 436717004505 catalytic residues [active] 436717004506 Transmembrane amino acid transporter protein; Region: Aa_trans; cl00524 436717004507 Amino acid permease; Region: AA_permease; pfam00324 436717004508 Transcriptional regulator [Transcription]; Region: LysR; COG0583 436717004509 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 436717004510 The C-terminal substrate binding domain of LysR-type transcriptional regulators that are involved in the catabolism of dinitrotoluene, naphthalene and gamma-hexachlorohexane; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_NahR_LinR_like; cd08459 436717004511 substrate binding pocket [chemical binding]; other site 436717004512 dimerization interface [polypeptide binding]; other site 436717004513 Gentisate 1,2-dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3435 436717004514 Cupin domain; Region: Cupin_2; cl09118 436717004515 salicylate hydroxylase; Provisional; Region: PRK08163 436717004516 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 436717004517 GST_N family, Class Zeta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens...; Region: GST_N_Zeta; cd03042 436717004518 maleylacetoacetate isomerase; Region: maiA; TIGR01262 436717004519 C-terminal domain interface [polypeptide binding]; other site 436717004520 GSH binding site (G-site) [chemical binding]; other site 436717004521 putative dimer interface [polypeptide binding]; other site 436717004522 GST_C family, Class Zeta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens...; Region: GST_C_Zeta; cd03191 436717004523 dimer interface [polypeptide binding]; other site 436717004524 N-terminal domain interface [polypeptide binding]; other site 436717004525 putative maleylacetoacetate (MAA) substrate binding site (H site); other site 436717004526 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 436717004527 benzoate transport; Region: 2A0115; TIGR00895 436717004528 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 436717004529 putative substrate translocation pore; other site 436717004530 outer membrane porin, OprD family; Region: OprD; pfam03573 436717004531 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 436717004532 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 436717004533 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 436717004534 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 436717004535 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 436717004536 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 436717004537 Alpha-Ketoglutaric Semialdehyde Dehydrogenase; Region: ALDH_KGSADH; cd07129 436717004538 dimer interface [polypeptide binding]; other site 436717004539 NADP binding site [chemical binding]; other site 436717004540 catalytic residues [active] 436717004541 Dehydratase family; Region: ILVD_EDD; cl00340 436717004542 dihydroxy-acid dehydratase; Region: ilvD; TIGR00110 436717004543 Fumarylacetoacetate (FAA) hydrolase family protein [General function prediction only]; Region: COG3970 436717004544 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 436717004545 Transcriptional regulator [Transcription]; Region: LysR; COG0583 436717004546 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 436717004547 The C-terminal substrate binding domain of galactose-binding protein regulator contains the type 2 periplasmic binding fold; Region: PBP2_GbpR; cd08435 436717004548 putative dimerization interface [polypeptide binding]; other site 436717004549 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 436717004550 Escherichia coli Gne (a nucleoside-diphosphate-sugar 4-epimerase)-like, extended (e) SDRs; Region: Gne_like_SDR_e; cd05238 436717004551 putative NAD(P) binding site [chemical binding]; other site 436717004552 active site 436717004553 putative substrate binding site [chemical binding]; other site 436717004554 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 436717004555 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 436717004556 putative substrate translocation pore; other site 436717004557 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 436717004558 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 436717004559 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 436717004560 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 436717004561 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 436717004562 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 436717004563 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 436717004564 putative NAD(P) binding site [chemical binding]; other site 436717004565 putative substrate binding site [chemical binding]; other site 436717004566 catalytic Zn binding site [ion binding]; other site 436717004567 structural Zn binding site [ion binding]; other site 436717004568 dimer interface [polypeptide binding]; other site 436717004569 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 436717004570 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 436717004571 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 436717004572 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface...; Region: TroA-like; cl00262 436717004573 intersubunit interface [polypeptide binding]; other site 436717004574 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist...; Region: TM_ABC_iron-siderophores_like; cd06550 436717004575 ABC-ATPase subunit interface; other site 436717004576 dimer interface [polypeptide binding]; other site 436717004577 putative PBP binding regions; other site 436717004578 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 436717004579 ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea. Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 436717004580 Walker A/P-loop; other site 436717004581 ATP binding site [chemical binding]; other site 436717004582 Q-loop/lid; other site 436717004583 ABC transporter signature motif; other site 436717004584 Walker B; other site 436717004585 D-loop; other site 436717004586 H-loop/switch region; other site 436717004587 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 436717004588 Coenzyme A binding pocket [chemical binding]; other site 436717004589 Cupin domain; Region: Cupin_2; cl09118 436717004590 Helix-turn-helix domain; Region: HTH_18; pfam12833 436717004591 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 436717004592 Predicted permeases [General function prediction only]; Region: COG0730; cl00498 436717004593 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 436717004594 putative nicotinate phosphoribosyltransferase; Provisional; Region: PRK09198 436717004595 pre-B-cell colony-enhancing factor (PBEF)-like. The mammalian members of this group of nicotinate phosphoribosyltransferases (NAPRTases) were originally identified as genes whose expression is upregulated upon activation in lymphoid cells. In general...; Region: PBEF_like; cd01569 436717004596 active site 436717004597 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or...; Region: Nudix_Hydrolase; cl00447 436717004598 nudix motif; other site 436717004599 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or...; Region: Nudix_Hydrolase; cl00447 436717004600 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine...; Region: MTHFR; cl00246 436717004601 FAD binding site [chemical binding]; other site 436717004602 Methylene-tetrahydrofolate reductase C terminal; Region: MTHFR_C; pfam12225 436717004603 LuxR family transcriptional regulatory, chaperone HchA-associated; Region: reg_near_HchA; TIGR03541 436717004604 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 436717004605 DNA binding residues [nucleotide binding] 436717004606 dimerization interface [polypeptide binding]; other site 436717004607 indole acetimide hydrolase; Validated; Region: PRK07488 436717004608 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl11426 436717004609 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 436717004610 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 436717004611 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 436717004612 putative substrate translocation pore; other site 436717004613 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 436717004614 GH3 auxin-responsive promoter; Region: GH3; cl04006 436717004615 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 436717004616 Outer membrane efflux protein; Region: OEP; pfam02321 436717004617 Outer membrane efflux protein; Region: OEP; pfam02321 436717004618 Survival protein SurE; Region: SurE; cl00448 436717004619 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 436717004620 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 436717004621 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 436717004622 Uncharacterized conserved protein [Function unknown]; Region: COG4104 436717004623 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 436717004624 Transcriptional regulator [Transcription]; Region: IclR; COG1414 436717004625 Bacterial transcriptional regulator; Region: IclR; pfam01614 436717004626 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110 436717004627 Citrate transporter; Region: CitMHS; pfam03600 436717004628 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 436717004629 active site 436717004630 catalytic residues [active] 436717004631 metal binding site [ion binding]; metal-binding site 436717004632 CoA-transferase family III; Region: CoA_transf_3; cl00778 436717004633 HipA-like N-terminal domain; Region: HipA_N; pfam07805 436717004634 HipA-like C-terminal domain; Region: HipA_C; pfam07804 436717004635 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl09100 436717004636 Isochorismatase family; Region: Isochorismatase; pfam00857 436717004637 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them...; Region: YcaC_related; cd01012 436717004638 catalytic triad [active] 436717004639 dimer interface [polypeptide binding]; other site 436717004640 conserved cis-peptide bond; other site 436717004641 Phospholipase/Carboxylesterase; Region: Abhydrolase_2; pfam02230 436717004642 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 436717004643 DoxX; Region: DoxX; cl00976 436717004644 Transcriptional regulator [Transcription]; Region: LysR; COG0583 436717004645 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 436717004646 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 436717004647 putative effector binding pocket; other site 436717004648 dimerization interface [polypeptide binding]; other site 436717004649 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 436717004650 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 436717004651 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 436717004652 dimer interface [polypeptide binding]; other site 436717004653 phosphorylation site [posttranslational modification] 436717004654 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 436717004655 ATP binding site [chemical binding]; other site 436717004656 Mg2+ binding site [ion binding]; other site 436717004657 G-X-G motif; other site 436717004658 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 436717004659 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 436717004660 active site 436717004661 phosphorylation site [posttranslational modification] 436717004662 intermolecular recognition site; other site 436717004663 dimerization interface [polypeptide binding]; other site 436717004664 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 436717004665 DNA binding site [nucleotide binding] 436717004666 periplasmic multidrug efflux lipoprotein precursor; Reviewed; Region: PRK09578 436717004667 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 436717004668 Protein export membrane protein; Region: SecD_SecF; cl14618 436717004669 copper/silver efflux system outer membrane protein CusC; Provisional; Region: PRK09837 436717004670 Outer membrane efflux protein; Region: OEP; pfam02321 436717004671 Outer membrane efflux protein; Region: OEP; pfam02321 436717004672 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 436717004673 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 436717004674 benzoate transport; Region: 2A0115; TIGR00895 436717004675 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 436717004676 putative substrate translocation pore; other site 436717004677 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 436717004678 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 436717004679 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 436717004680 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 436717004681 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 436717004682 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 436717004683 Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl14881 436717004684 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 436717004685 Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; cl09488 436717004686 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 436717004687 Walker A/P-loop; other site 436717004688 ATP binding site [chemical binding]; other site 436717004689 Q-loop/lid; other site 436717004690 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 436717004691 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 436717004692 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 436717004693 Walker A/P-loop; other site 436717004694 ATP binding site [chemical binding]; other site 436717004695 Q-loop/lid; other site 436717004696 ABC transporter signature motif; other site 436717004697 Walker B; other site 436717004698 D-loop; other site 436717004699 H-loop/switch region; other site 436717004700 Uncharacterized conserved protein (DUF2132); Region: DUF2132; cl01894 436717004701 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 436717004702 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 436717004703 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 436717004704 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG...; Region: CAS_like; cl00184 436717004705 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 436717004706 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 436717004707 ligand binding site [chemical binding]; other site 436717004708 flexible hinge region; other site 436717004709 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 436717004710 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 436717004711 Sulfatase; Region: Sulfatase; cl10460 436717004712 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 436717004713 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 436717004714 N-terminal plug; other site 436717004715 ligand-binding site [chemical binding]; other site 436717004716 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 436717004717 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and...; Region: Aldo_ket_red; cd06660 436717004718 active site 436717004719 catalytic tetrad [active] 436717004720 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 436717004721 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 436717004722 active site 436717004723 non-prolyl cis peptide bond; other site 436717004724 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 436717004725 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 436717004726 N-terminal plug; other site 436717004727 ligand-binding site [chemical binding]; other site 436717004728 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 436717004729 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 436717004730 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 436717004731 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG...; Region: CAS_like; cl00184 436717004732 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 436717004733 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 436717004734 ligand binding site [chemical binding]; other site 436717004735 flexible hinge region; other site 436717004736 Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537 436717004737 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 436717004738 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 436717004739 Gram-negative bacterial tonB protein; Region: TonB; cl10048 436717004740 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 436717004741 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars...; Region: ABC_NrtD_SsuB_transporters; cd03293 436717004742 Walker A/P-loop; other site 436717004743 ATP binding site [chemical binding]; other site 436717004744 Q-loop/lid; other site 436717004745 ABC transporter signature motif; other site 436717004746 Walker B; other site 436717004747 D-loop; other site 436717004748 H-loop/switch region; other site 436717004749 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 436717004750 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cl00427 436717004751 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cl00427 436717004752 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 436717004753 active site 436717004754 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 436717004755 dimer interface [polypeptide binding]; other site 436717004756 non-prolyl cis peptide bond; other site 436717004757 insertion regions; other site 436717004758 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 436717004759 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 436717004760 N-terminal plug; other site 436717004761 ligand-binding site [chemical binding]; other site 436717004762 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16...; Region: OM_channels; cl00284 436717004763 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16...; Region: OM_channels; cl00284 436717004764 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_17; cd08503 436717004765 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 436717004766 Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537 436717004767 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 436717004768 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 436717004769 Gram-negative bacterial tonB protein; Region: TonB; cl10048 436717004770 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 436717004771 active site 436717004772 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 436717004773 dimer interface [polypeptide binding]; other site 436717004774 non-prolyl cis peptide bond; other site 436717004775 insertion regions; other site 436717004776 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 436717004777 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 436717004778 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cl00427 436717004779 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 436717004780 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 436717004781 dimer interface [polypeptide binding]; other site 436717004782 conserved gate region; other site 436717004783 ABC-ATPase subunit interface; other site 436717004784 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 436717004785 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars...; Region: ABC_NrtD_SsuB_transporters; cd03293 436717004786 Walker A/P-loop; other site 436717004787 ATP binding site [chemical binding]; other site 436717004788 Q-loop/lid; other site 436717004789 ABC transporter signature motif; other site 436717004790 Walker B; other site 436717004791 D-loop; other site 436717004792 H-loop/switch region; other site 436717004793 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 436717004794 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 436717004795 Sec-independent protein translocase protein (TatC); Region: TatC; cl00521 436717004796 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 436717004797 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 436717004798 Walker A motif; other site 436717004799 ATP binding site [chemical binding]; other site 436717004800 Walker B motif; other site 436717004801 arginine finger; other site 436717004802 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 436717004803 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 436717004804 dimer interface [polypeptide binding]; other site 436717004805 active site 436717004806 non-prolyl cis peptide bond; other site 436717004807 insertion regions; other site 436717004808 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 436717004809 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 436717004810 N-terminal plug; other site 436717004811 ligand-binding site [chemical binding]; other site 436717004812 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 436717004813 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 436717004814 Glucan exporter ATP-binding protein. In A. tumefaciens cyclic beta-1, 2-glucan must be transported into the periplasmic space to exert its action as a virluence factor. This subfamily belongs to the MRP-like family and is involved in drug, peptide...; Region: ABCC_Glucan_exporter_like; cd03254 436717004815 Walker A/P-loop; other site 436717004816 ATP binding site [chemical binding]; other site 436717004817 Q-loop/lid; other site 436717004818 ABC transporter signature motif; other site 436717004819 Walker B; other site 436717004820 D-loop; other site 436717004821 H-loop/switch region; other site 436717004822 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 436717004823 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 436717004824 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 436717004825 Walker A/P-loop; other site 436717004826 ATP binding site [chemical binding]; other site 436717004827 Q-loop/lid; other site 436717004828 ABC transporter signature motif; other site 436717004829 Walker B; other site 436717004830 D-loop; other site 436717004831 H-loop/switch region; other site 436717004832 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 436717004833 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 436717004834 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 436717004835 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 436717004836 active site 436717004837 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 436717004838 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 436717004839 Walker A/P-loop; other site 436717004840 ATP binding site [chemical binding]; other site 436717004841 Q-loop/lid; other site 436717004842 ABC transporter signature motif; other site 436717004843 Walker B; other site 436717004844 D-loop; other site 436717004845 H-loop/switch region; other site 436717004846 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 436717004847 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 436717004848 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 436717004849 Walker A/P-loop; other site 436717004850 ATP binding site [chemical binding]; other site 436717004851 Q-loop/lid; other site 436717004852 ABC transporter signature motif; other site 436717004853 Walker B; other site 436717004854 D-loop; other site 436717004855 H-loop/switch region; other site 436717004856 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 436717004857 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 436717004858 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 436717004859 dimer interface [polypeptide binding]; other site 436717004860 conserved gate region; other site 436717004861 putative PBP binding loops; other site 436717004862 ABC-ATPase subunit interface; other site 436717004863 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 436717004864 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 436717004865 dimer interface [polypeptide binding]; other site 436717004866 conserved gate region; other site 436717004867 putative PBP binding loops; other site 436717004868 ABC-ATPase subunit interface; other site 436717004869 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_17; cd08503 436717004870 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 436717004871 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 436717004872 active site 436717004873 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 436717004874 dimer interface [polypeptide binding]; other site 436717004875 non-prolyl cis peptide bond; other site 436717004876 insertion regions; other site 436717004877 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II)...; Region: Aldolase_II; cl00214 436717004878 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 436717004879 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 436717004880 Fimbrial protein; Region: Fimbrial; cl01416 436717004881 putative chaperone protein EcpD; Provisional; Region: PRK09926 436717004882 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 436717004883 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 436717004884 pilin outer membrane usher protein SafC; Provisional; Region: PRK15223; cl14650 436717004885 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 436717004886 Fimbrial protein; Region: Fimbrial; cl01416 436717004887 class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300 436717004888 S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase; Region: adh_III_F_hyde; TIGR02818 436717004889 substrate binding site [chemical binding]; other site 436717004890 catalytic Zn binding site [ion binding]; other site 436717004891 NAD binding site [chemical binding]; other site 436717004892 structural Zn binding site [ion binding]; other site 436717004893 dimer interface [polypeptide binding]; other site 436717004894 Catalase-like heme-binding proteins similar to the uncharacterized y4iL; Region: y4iL_like; cd08152 436717004895 putative heme binding pocket [chemical binding]; other site 436717004896 Glutathione-dependent formaldehyde-activating enzyme; Region: GFA; cl01553 436717004897 Putative catalytic domain, repeat 1, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_1; cd09111 436717004898 putative active site [active] 436717004899 catalytic site [active] 436717004900 Putative catalytic domain, repeat 2, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_2; cd09113 436717004901 putative active site [active] 436717004902 catalytic site [active] 436717004903 Uracil DNA glycosylase superfamily; Region: UDG; cl00483 436717004904 renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics...; Region: rDP_like; cd01301 436717004905 active site 436717004906 dimer interface [polypeptide binding]; other site 436717004907 pyrroloquinoline quinone biosynthesis protein PqqE; Provisional; Region: PRK05301 436717004908 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 436717004909 FeS/SAM binding site; other site 436717004910 radical SAM additional 4Fe4S-binding domain; Region: rSAM_more_4Fe4S; TIGR04085 436717004911 Coenzyme PQQ synthesis protein D (PqqD); Region: PqqD; cl05126 436717004912 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cl15243 436717004913 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 436717004914 coenzyme PQQ synthesis protein PqqA; Provisional; Region: pqqA; cl14189 436717004915 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 436717004916 Bacillus subtilis YhcR endonuclease and related proteins, N-terminal metallophosphatase domain; Region: MPP_YhcR_N; cd07412 436717004917 putative active site [active] 436717004918 putative metal binding site [ion binding]; other site 436717004919 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 436717004920 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 436717004921 metal binding site 2 [ion binding]; metal-binding site 436717004922 putative DNA binding helix; other site 436717004923 metal binding site 1 [ion binding]; metal-binding site 436717004924 dimer interface [polypeptide binding]; other site 436717004925 structural Zn2+ binding site [ion binding]; other site 436717004926 Outer membrane receptor for ferrienterochelin and colicins [Inorganic ion transport and metabolism]; Region: FepA; COG4771 436717004927 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 436717004928 N-terminal plug; other site 436717004929 ligand-binding site [chemical binding]; other site 436717004930 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 436717004931 Protein export membrane protein; Region: SecD_SecF; cl14618 436717004932 Isochorismatase, also known as 2,3 dihydro-2,3 dihydroxybenzoate synthase, catalyses the conversion of isochorismate, in the presence of water, to 2,3-dihydroxybenzoate and pyruvate, via the hydrolysis of a vinyl ether, an uncommon reaction in...; Region: isochorismatase; cd01013 436717004933 hydrophobic substrate binding pocket; other site 436717004934 Isochorismatase family; Region: Isochorismatase; pfam00857 436717004935 active site 436717004936 conserved cis-peptide bond; other site 436717004937 Phosphopantetheine attachment site; Region: PP-binding; cl09936 436717004938 Peptide arylation enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntE; COG1021 436717004939 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 436717004940 isochorismate synthase DhbC; Validated; Region: PRK06923 436717004941 chorismate binding enzyme; Region: Chorismate_bind; cl10555 436717004942 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 436717004943 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 436717004944 NAD(P) binding site [chemical binding]; other site 436717004945 active site 436717004946 enterobactin/ferric enterobactin esterase; Provisional; Region: PRK10439 436717004947 Domain of unknown function (DUF3327); Region: DUF3327; pfam11806 436717004948 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 436717004949 MbtH-like protein; Region: MbtH; cl01279 436717004950 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 436717004951 Condensation domain; Region: Condensation; cl09290 436717004952 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 436717004953 Phosphopantetheine attachment site; Region: PP-binding; cl09936 436717004954 Condensation domain; Region: Condensation; cl09290 436717004955 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 436717004956 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 436717004957 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 436717004958 Phosphopantetheine attachment site; Region: PP-binding; cl09936 436717004959 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 436717004960 enterobactin exporter EntS; Provisional; Region: PRK10489 436717004961 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 436717004962 putative substrate translocation pore; other site 436717004963 Phosphopantetheinyl transferase component of siderophore synthetase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntD; COG2977 436717004964 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500 436717004965 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 436717004966 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 436717004967 Walker A/P-loop; other site 436717004968 ATP binding site [chemical binding]; other site 436717004969 Q-loop/lid; other site 436717004970 ABC transporter signature motif; other site 436717004971 Walker B; other site 436717004972 D-loop; other site 436717004973 H-loop/switch region; other site 436717004974 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 436717004975 dimer interface [polypeptide binding]; other site 436717004976 conserved gate region; other site 436717004977 putative PBP binding loops; other site 436717004978 ABC-ATPase subunit interface; other site 436717004979 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 436717004980 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 436717004981 anthranilate 1,2-dioxygenase, large subunit; Region: anthran_1_2_A; TIGR03228 436717004982 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 436717004983 [2Fe-2S] cluster binding site [ion binding]; other site 436717004984 C-terminal catalytic domain of the oxygenase alpha subunit of Pseudomonas resinovorans strain CA10 anthranilate 1,2-dioxygenase and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_AntDO-like; cd08879 436717004985 putative alpha subunit interface [polypeptide binding]; other site 436717004986 putative active site [active] 436717004987 putative substrate binding site [chemical binding]; other site 436717004988 Fe binding site [ion binding]; other site 436717004989 Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667 436717004990 inter-subunit interface; other site 436717004991 anthranilate dioxygenase reductase; Provisional; Region: antC; PRK11872 436717004992 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 436717004993 catalytic loop [active] 436717004994 iron binding site [ion binding]; other site 436717004995 Benzoate dioxygenase reductase (BenDO) FAD/NAD binding domain. Oxygenases oxidize hydrocarbons using dioxygen as the oxidant. As a Class I bacterial dioxygenases, benzoate dioxygenase like proteins combine an [2Fe-2S] cluster containing N-terminal...; Region: BenDO_FAD_NAD; cd06209 436717004996 FAD binding pocket [chemical binding]; other site 436717004997 FAD binding motif [chemical binding]; other site 436717004998 phosphate binding motif [ion binding]; other site 436717004999 beta-alpha-beta structure motif; other site 436717005000 NAD binding pocket [chemical binding]; other site 436717005001 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 436717005002 Helix-turn-helix domain; Region: HTH_18; pfam12833 436717005003 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 436717005004 Protein involved in meta-pathway of phenol degradation [Energy production and conversion]; Region: COG4313 436717005005 Flavin Reductases; Region: FlaRed; cl00801 436717005006 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 436717005007 classical (c) SDRs; Region: SDR_c; cd05233 436717005008 NAD(P) binding site [chemical binding]; other site 436717005009 active site 436717005010 Dienelactone hydrolase family; Region: DLH; pfam01738 436717005011 outer membrane porin, OprD family; Region: OprD; pfam03573 436717005012 benzoate transport; Region: 2A0115; TIGR00895 436717005013 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 436717005014 putative substrate translocation pore; other site 436717005015 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 436717005016 Helix-turn-helix domain; Region: HTH_18; pfam12833 436717005017 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 436717005018 3-hydroxybutyrate dehydrogenase; Region: PHB_DH; TIGR01963 436717005019 NAD(P) binding site [chemical binding]; other site 436717005020 active site 436717005021 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110 436717005022 Citrate transporter; Region: CitMHS; pfam03600 436717005023 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 436717005024 Sensors of blue-light using FAD; Region: BLUF; pfam04940 436717005025 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 436717005026 active site 436717005027 Helix-turn-helix domain; Region: HTH_18; pfam12833 436717005028 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 436717005029 Major Facilitator Superfamily; Region: MFS_1; pfam07690 436717005030 putative substrate translocation pore; other site 436717005031 Protein of unknown function (DUF2846); Region: DUF2846; pfam11008 436717005032 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 436717005033 Transcriptional regulator [Transcription]; Region: LysR; COG0583 436717005034 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 436717005035 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 436717005036 putative dimerization interface [polypeptide binding]; other site 436717005037 Coenzyme A transferase; Region: CoA_trans; cl00773 436717005038 Coenzyme A transferase; Region: CoA_trans; cl00773 436717005039 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110 436717005040 acetyl-CoA acetyltransferase; Provisional; Region: PRK06954 436717005041 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 436717005042 dimer interface [polypeptide binding]; other site 436717005043 active site 436717005044 Transcriptional regulator [Transcription]; Region: LysR; COG0583 436717005045 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 436717005046 The C-terminal substrate binding domain of LysR-type transcriptional regulators that are involved in the catabolism of dinitrotoluene, naphthalene and gamma-hexachlorohexane; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_NahR_LinR_like; cd08459 436717005047 substrate binding pocket [chemical binding]; other site 436717005048 dimerization interface [polypeptide binding]; other site 436717005049 cell density-dependent motility repressor; Provisional; Region: PRK10082 436717005050 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 436717005051 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 436717005052 dimerization interface [polypeptide binding]; other site 436717005053 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 436717005054 Aspartase; Region: Aspartase; cd01357 436717005055 active sites [active] 436717005056 tetramer interface [polypeptide binding]; other site 436717005057 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 436717005058 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 436717005059 N-terminal plug; other site 436717005060 ligand-binding site [chemical binding]; other site 436717005061 alpha-ketoglutarate transporter; Provisional; Region: PRK10406 436717005062 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 436717005063 putative substrate translocation pore; other site 436717005064 Protein of unknown function (DUF971); Region: DUF971; cl01414 436717005065 putative oxidoreductase/HEAT repeat-containing protein; Provisional; Region: PRK13800 436717005066 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 436717005067 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars...; Region: ABC_NrtD_SsuB_transporters; cd03293 436717005068 Walker A/P-loop; other site 436717005069 ATP binding site [chemical binding]; other site 436717005070 Q-loop/lid; other site 436717005071 ABC transporter signature motif; other site 436717005072 Walker B; other site 436717005073 D-loop; other site 436717005074 H-loop/switch region; other site 436717005075 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 436717005076 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 436717005077 dimer interface [polypeptide binding]; other site 436717005078 conserved gate region; other site 436717005079 putative PBP binding loops; other site 436717005080 ABC-ATPase subunit interface; other site 436717005081 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 436717005082 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 436717005083 archaeoflavoprotein, MJ0208 family; Region: flavo_MJ0208; TIGR02700 436717005084 putative oxidoreductase; Provisional; Region: PRK08275 436717005085 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 436717005086 domain; Region: Succ_DH_flav_C; pfam02910 436717005087 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 436717005088 DNA-binding site [nucleotide binding]; DNA binding site 436717005089 UTRA domain; Region: UTRA; cl06649 436717005090 DNA-binding transcriptional activator DcuR; Provisional; Region: PRK10430 436717005091 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 436717005092 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 436717005093 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 436717005094 EamA-like transporter family; Region: EamA; cl01037 436717005095 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 436717005096 EamA-like transporter family; Region: EamA; cl01037 436717005097 homoserine dehydrogenase; Provisional; Region: PRK06270 436717005098 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 436717005099 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 436717005100 Predicted permeases [General function prediction only]; Region: COG0730; cl00498 436717005101 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr (; Region: PTPc; cl00053 436717005102 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 436717005103 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 436717005104 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 436717005105 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 436717005106 Walker A motif; other site 436717005107 ATP binding site [chemical binding]; other site 436717005108 Walker B motif; other site 436717005109 arginine finger; other site 436717005110 Bestrophin, RFP-TM, chloride channel; Region: Bestrophin; cl01544 436717005111 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 436717005112 (2R,3R)-2,3-butanediol dehydrogenase; Region: butanediol_DH_like; cd08233 436717005113 putative NAD(P) binding site [chemical binding]; other site 436717005114 catalytic Zn binding site [ion binding]; other site 436717005115 acetoin reductases; Region: 23BDH; TIGR02415 436717005116 meso-2,3-butanediol dehydrogenase-like, classical (c) SDRs; Region: meso-BDH-like_SDR_c; cd05366 436717005117 NAD binding site [chemical binding]; other site 436717005118 homotetramer interface [polypeptide binding]; other site 436717005119 homodimer interface [polypeptide binding]; other site 436717005120 active site 436717005121 substrate binding site [chemical binding]; other site 436717005122 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 436717005123 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 436717005124 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 436717005125 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 436717005126 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 436717005127 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 436717005128 E3 interaction surface; other site 436717005129 lipoyl attachment site [posttranslational modification]; other site 436717005130 dihydrolipoamide acetyltransferase; Provisional; Region: PRK14843 436717005131 e3 binding domain; Region: E3_binding; pfam02817 436717005132 e3 binding domain; Region: E3_binding; pfam02817 436717005133 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008 436717005134 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 436717005135 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 436717005136 alpha subunit interface [polypeptide binding]; other site 436717005137 TPP binding site [chemical binding]; other site 436717005138 heterodimer interface [polypeptide binding]; other site 436717005139 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 436717005140 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 436717005141 tetramer interface [polypeptide binding]; other site 436717005142 TPP-binding site [chemical binding]; other site 436717005143 heterodimer interface [polypeptide binding]; other site 436717005144 phosphorylation loop region [posttranslational modification] 436717005145 lipoyl synthase; Provisional; Region: PRK12928 436717005146 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 436717005147 FeS/SAM binding site; other site 436717005148 DNA-binding transcriptional regulator DhaR; Provisional; Region: PRK11388 436717005149 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cl15243 436717005150 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 436717005151 metal binding site [ion binding]; metal-binding site 436717005152 active site 436717005153 I-site; other site 436717005154 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 436717005155 Tetramer interface [polypeptide binding]; other site 436717005156 Active site [active] 436717005157 FMN-binding site [chemical binding]; other site 436717005158 HemK family putative methylases; Region: hemK_fam; TIGR00536 436717005159 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 436717005160 S-adenosylmethionine binding site [chemical binding]; other site 436717005161 tryptophan synthase, beta chain; Region: PLN02618 436717005162 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 436717005163 pyridoxal 5'-phosphate binding site [chemical binding]; other site 436717005164 catalytic residue [active] 436717005165 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 436717005166 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 436717005167 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 436717005168 Walker A motif; other site 436717005169 ATP binding site [chemical binding]; other site 436717005170 Walker B motif; other site 436717005171 arginine finger; other site 436717005172 YcgL domain; Region: YcgL; cl01189 436717005173 Transcriptional regulator [Transcription]; Region: LysR; COG0583 436717005174 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 436717005175 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 436717005176 dimerization interface [polypeptide binding]; other site 436717005177 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 436717005178 ribonuclease D; Region: rnd; TIGR01388 436717005179 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 436717005180 putative active site [active] 436717005181 catalytic site [active] 436717005182 putative substrate binding site [chemical binding]; other site 436717005183 HRDC domain; Region: HRDC; cl02578 436717005184 recombination protein RecR; Reviewed; Region: recR; PRK00076 436717005185 RecR protein; Region: RecR; pfam02132 436717005186 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 436717005187 putative active site [active] 436717005188 putative metal-binding site [ion binding]; other site 436717005189 tetramer interface [polypeptide binding]; other site 436717005190 Uncharacterised BCR, YbaB family COG0718; Region: DUF149; cl00494 436717005191 O-succinylhomoserine sulfhydrylase; Validated; Region: PRK08133 436717005192 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 436717005193 homodimer interface [polypeptide binding]; other site 436717005194 substrate-cofactor binding pocket; other site 436717005195 pyridoxal 5'-phosphate binding site [chemical binding]; other site 436717005196 catalytic residue [active] 436717005197 PhaC subunit; Region: PHA_synth_III_C; TIGR01836 436717005198 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 436717005199 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 436717005200 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 436717005201 NAD(P) binding pocket [chemical binding]; other site 436717005202 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life...; Region: HINT_subgroup; cd01277 436717005203 HIT family signature motif; other site 436717005204 catalytic residue [active] 436717005205 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface...; Region: gram_neg_porins; cd00342 436717005206 eyelet of channel; other site 436717005207 trimer interface [polypeptide binding]; other site 436717005208 Bacterial protein of unknown function (DUF937); Region: DUF937; cl01528 436717005209 Protein of unknown function (DUF2797); Region: DUF2797; pfam10977 436717005210 ABC-2 type transporter; Region: ABC2_membrane; cl11417 436717005211 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 436717005212 ABC-2 type transporter; Region: ABC2_membrane; cl11417 436717005213 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 436717005214 The ABCA subfamily mediates the transport of a variety of lipid compounds. Mutations of members of ABCA subfamily are associated with human genetic diseases, such as, familial high-density lipoprotein (HDL) deficiency, neonatal surfactant deficiency...; Region: ABC_subfamily_A; cd03263 436717005215 Walker A/P-loop; other site 436717005216 ATP binding site [chemical binding]; other site 436717005217 Q-loop/lid; other site 436717005218 ABC transporter signature motif; other site 436717005219 Walker B; other site 436717005220 D-loop; other site 436717005221 H-loop/switch region; other site 436717005222 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 436717005223 The ABCA subfamily mediates the transport of a variety of lipid compounds. Mutations of members of ABCA subfamily are associated with human genetic diseases, such as, familial high-density lipoprotein (HDL) deficiency, neonatal surfactant deficiency...; Region: ABC_subfamily_A; cd03263 436717005224 Walker A/P-loop; other site 436717005225 ATP binding site [chemical binding]; other site 436717005226 Q-loop/lid; other site 436717005227 ABC transporter signature motif; other site 436717005228 Walker B; other site 436717005229 D-loop; other site 436717005230 H-loop/switch region; other site 436717005231 putative efflux pump membrane fusion protein; Provisional; Region: PRK03598 436717005232 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2...; Region: Biotinyl_lipoyl_domains; cl11404 436717005233 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11552 436717005234 Domain of unknown function (DUF1956); Region: DUF1956; pfam09209 436717005235 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 436717005236 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 436717005237 Outer membrane receptor for ferric coprogen and ferric-rhodotorulic acid [Inorganic ion transport and metabolism]; Region: FhuE; COG4773 436717005238 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 436717005239 N-terminal plug; other site 436717005240 ligand-binding site [chemical binding]; other site 436717005241 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 436717005242 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 436717005243 Predicted permeases [General function prediction only]; Region: COG0730; cl00498 436717005244 NeuB family; Region: NeuB; cl00496 436717005245 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 436717005246 Cobalamin-5-phosphate synthase; Region: CobS; cl00415 436717005247 Histidine phosphatase superfamily (branch 2); Region: His_Phos_2; pfam00328 436717005248 Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061 436717005249 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 436717005250 catalytic core [active] 436717005251 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 436717005252 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 436717005253 putative dimer interface [polypeptide binding]; other site 436717005254 active site pocket [active] 436717005255 putative cataytic base [active] 436717005256 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is...; Region: CobU; cd00544 436717005257 homotrimer interface [polypeptide binding]; other site 436717005258 Walker A motif; other site 436717005259 GTP binding site [chemical binding]; other site 436717005260 Walker B motif; other site 436717005261 2'-5' RNA ligase [Translation, ribosomal structure and biogenesis]; Region: LigT; COG1514 436717005262 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 436717005263 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 436717005264 motif II; other site 436717005265 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 436717005266 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS); Region: YbaK_deacylase; cd00002 436717005267 putative deacylase active site [active] 436717005268 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 436717005269 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 436717005270 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 436717005271 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 436717005272 active site 436717005273 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 436717005274 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 436717005275 active site 436717005276 Alkane hydroxylase is a bacterial, integral-membrane di-iron enzyme that shares a requirement for iron and oxygen for activity similar to that of the non-heme integral-membrane acyl coenzyme A (CoA) desaturases and acyl lipid desaturases. The alk genes...; Region: Alkane-hydroxylase; cd03512 436717005277 Di-iron ligands [ion binding]; other site 436717005278 Cupin domain; Region: Cupin_2; cl09118 436717005279 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 436717005280 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 436717005281 periplasmic folding chaperone; Provisional; Region: PRK10788 436717005282 SurA N-terminal domain; Region: SurA_N; pfam09312 436717005283 PPIC-type PPIASE domain; Region: Rotamase; cl08278 436717005284 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and higher-...; Region: HU_IHF; cd00591 436717005285 IHF dimer interface [polypeptide binding]; other site 436717005286 IHF - DNA interface [nucleotide binding]; other site 436717005287 Poly(hydroxyalcanoate) granule associated protein (phasin); Region: Phasin; cl07863 436717005288 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 436717005289 Rrf2 family protein; Region: rrf2_super; TIGR00738 436717005290 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 436717005291 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 436717005292 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 436717005293 catalytic residue [active] 436717005294 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 436717005295 trimerization site [polypeptide binding]; other site 436717005296 active site 436717005297 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 436717005298 co-chaperone HscB; Provisional; Region: hscB; PRK05014 436717005299 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of...; Region: DnaJ; cd06257 436717005300 HSP70 interaction site [polypeptide binding]; other site 436717005301 HSCB C-terminal oligomerisation domain; Region: HSCB_C; pfam07743 436717005302 chaperone protein HscA; Provisional; Region: hscA; PRK05183 436717005303 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 436717005304 catalytic loop [active] 436717005305 iron binding site [ion binding]; other site 436717005306 cyclase homology domain; Region: CHD; cd07302 436717005307 nucleotidyl binding site; other site 436717005308 metal binding site [ion binding]; metal-binding site 436717005309 dimer interface [polypeptide binding]; other site 436717005310 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the...; Region: HIT_like; cl00228 436717005311 transcription-repair coupling factor; Provisional; Region: PRK10689 436717005312 CarD-like/TRCF domain; Region: CarD_TRCF; cl00588 436717005313 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 436717005314 ATP binding site [chemical binding]; other site 436717005315 putative Mg++ binding site [ion binding]; other site 436717005316 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 436717005317 nucleotide binding region [chemical binding]; other site 436717005318 ATP-binding site [chemical binding]; other site 436717005319 TRCF domain; Region: TRCF; pfam03461 436717005320 Dyp-type peroxidase family; Region: Dyp_perox; cl01067 436717005321 GST_N family, 2 repeats of the N-terminal domain of soluble GSTs (2 GST_N) subfamily; composed of uncharacterized proteins. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with...; Region: GST_N_2GST_N; cd03041 436717005322 putative C-terminal domain interface [polypeptide binding]; other site 436717005323 putative GSH binding site (G-site) [chemical binding]; other site 436717005324 putative dimer interface [polypeptide binding]; other site 436717005325 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 436717005326 Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480 436717005327 CC3(TIP30)-like, atypical (a) SDRs; Region: CC3_like_SDR_a; cd05250 436717005328 NAD binding site [chemical binding]; other site 436717005329 active site 436717005330 Ribosomal protein S20; Region: Ribosomal_S20p; cl00384 436717005331 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 436717005332 catalytic core [active] 436717005333 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in cysteine...; Region: CysQ; cd01638 436717005334 active site 436717005335 Uncharacterised ACR, COG2135; Region: DUF159; cl03646 436717005336 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 436717005337 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 436717005338 Walker A/P-loop; other site 436717005339 ATP binding site [chemical binding]; other site 436717005340 Q-loop/lid; other site 436717005341 ABC transporter signature motif; other site 436717005342 Walker B; other site 436717005343 D-loop; other site 436717005344 H-loop/switch region; other site 436717005345 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 436717005346 Walker A/P-loop; other site 436717005347 ATP binding site [chemical binding]; other site 436717005348 Q-loop/lid; other site 436717005349 ABC transporter signature motif; other site 436717005350 Walker B; other site 436717005351 D-loop; other site 436717005352 H-loop/switch region; other site 436717005353 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 436717005354 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 436717005355 dimer interface [polypeptide binding]; other site 436717005356 conserved gate region; other site 436717005357 putative PBP binding loops; other site 436717005358 ABC-ATPase subunit interface; other site 436717005359 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 436717005360 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 436717005361 dimer interface [polypeptide binding]; other site 436717005362 conserved gate region; other site 436717005363 putative PBP binding loops; other site 436717005364 ABC-ATPase subunit interface; other site 436717005365 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 436717005366 Peptidase M3 Thimet oligopeptidase (TOP) also includes neurolysin; Region: M3A_TOP; cd06455 436717005367 active site 436717005368 Zn binding site [ion binding]; other site 436717005369 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_18; cd08505 436717005370 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 436717005371 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_18; cd08505 436717005372 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 436717005373 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 436717005374 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 436717005375 N-terminal plug; other site 436717005376 ligand-binding site [chemical binding]; other site 436717005377 Gram-negative bacterial tonB protein; Region: TonB; cl10048 436717005378 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 436717005379 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 436717005380 Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537 436717005381 Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537 436717005382 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 436717005383 Malate synthase G (MSG), monomeric enzyme present in some bacteria. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to malyl-CoA , which hydrolyzes to malate and CoA. This reaction is part of the glyoxylate...; Region: malate_synt_G; cd00728 436717005384 active site 436717005385 Predicted ATPase [General function prediction only]; Region: COG1485 436717005386 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 436717005387 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 436717005388 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 436717005389 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 436717005390 Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl14881 436717005391 Membrane protein of unknown function (DUF340); Region: DUF340; cl01028 436717005392 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase contains two...; Region: OMP_decarboxylase_like; cd04725 436717005393 active site 436717005394 dimer interface [polypeptide binding]; other site 436717005395 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and higher-...; Region: HU_IHF; cd00591 436717005396 IHF dimer interface [polypeptide binding]; other site 436717005397 IHF - DNA interface [nucleotide binding]; other site 436717005398 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 436717005399 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 436717005400 RNA binding site [nucleotide binding]; other site 436717005401 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 436717005402 RNA binding site [nucleotide binding]; other site 436717005403 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists of...; Region: S1_RPS1_repeat_ec3; cd05688 436717005404 RNA binding site [nucleotide binding]; other site 436717005405 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain...; Region: S1_like; cl09927 436717005406 RNA binding site [nucleotide binding]; other site 436717005407 S1_RPS1_repeat_ec5: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists of...; Region: S1_RPS1_repeat_ec5; cd05690 436717005408 RNA binding site [nucleotide binding]; other site 436717005409 S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists of...; Region: S1_RPS1_repeat_ec6; cd05691 436717005410 RNA binding site [nucleotide binding]; other site 436717005411 cytidylate kinase; Provisional; Region: cmk; PRK00023 436717005412 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 436717005413 CMP-binding site; other site 436717005414 The sites determining sugar specificity; other site 436717005415 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 436717005416 putative hydrophobic ligand binding site [chemical binding]; other site 436717005417 protein interface [polypeptide binding]; other site 436717005418 gate; other site 436717005419 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 436717005420 nucleoside/Zn binding site; other site 436717005421 dimer interface [polypeptide binding]; other site 436717005422 catalytic motif [active] 436717005423 3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617 436717005424 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 436717005425 substrate binding site [chemical binding]; other site 436717005426 oxyanion hole (OAH) forming residues; other site 436717005427 trimer interface [polypeptide binding]; other site 436717005428 Uracil DNA glycosylase superfamily; Region: UDG; cl00483 436717005429 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 436717005430 General secretion pathway protein K; Region: GspK; pfam03934 436717005431 general secretion pathway protein J; Region: gspJ; TIGR01711 436717005432 Prokaryotic N-terminal methylation motif; Region: N_methyl; cl06830 436717005433 Pseudopilin GspJ; Region: GspJ; pfam11612 436717005434 Bacterial type II secretion system protein I/J; Region: GSPII_IJ; pfam02501 436717005435 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 436717005436 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 436717005437 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 436717005438 putative deoxyribonuclease YjjV; Provisional; Region: PRK11449 436717005439 active site 436717005440 PilZ domain; Region: PilZ; cl01260 436717005441 DNA polymerase III subunit delta'; Validated; Region: PRK05707 436717005442 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 436717005443 Ligand binding site [chemical binding]; other site 436717005444 oligomer interface [polypeptide binding]; other site 436717005445 Tetraacyldisaccharide-1-P 4'-kinase [Cell envelope biogenesis, outer membrane]; Region: LpxK; COG1663 436717005446 Tetraacyldisaccharide-1-P 4'-kinase; Region: LpxK; cl03652 436717005447 lipid A export permease/ATP-binding protein MsbA; Region: MsbA_lipidA; TIGR02203 436717005448 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 436717005449 MsbA is an essential ABC transporter, closely related to eukaryotic MDR proteins. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic...; Region: ABCC_MsbA; cd03251 436717005450 Walker A/P-loop; other site 436717005451 ATP binding site [chemical binding]; other site 436717005452 Q-loop/lid; other site 436717005453 ABC transporter signature motif; other site 436717005454 Walker B; other site 436717005455 D-loop; other site 436717005456 H-loop/switch region; other site 436717005457 Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537 436717005458 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 436717005459 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 436717005460 ParB-like partition proteins; Region: parB_part; TIGR00180 436717005461 ParB-like nuclease domain; Region: ParBc; cl02129 436717005462 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 436717005463 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following...; Region: ParA; cd02042 436717005464 P-loop; other site 436717005465 Magnesium ion binding site [ion binding]; other site 436717005466 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following...; Region: ParA; cd02042 436717005467 Magnesium ion binding site [ion binding]; other site 436717005468 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 436717005469 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 436717005470 NTP_transferase_like_1 is a member of the nucleotidyl transferase family; Region: NTP_transferase_like_1; cd06422 436717005471 Substrate binding site [chemical binding]; other site 436717005472 metal binding site [ion binding]; metal-binding site 436717005473 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 436717005474 Phosphotransferase enzyme family; Region: APH; pfam01636 436717005475 Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835 436717005476 Organic solvent tolerance protein; Region: OstA_C; pfam04453 436717005477 peptidyl-prolyl cis-trans isomerase SurA; Provisional; Region: PRK10770 436717005478 SurA N-terminal domain; Region: SurA_N; pfam09312 436717005479 PPIC-type PPIASE domain; Region: Rotamase; cl08278 436717005480 PPIC-type PPIASE domain; Region: Rotamase; cl08278 436717005481 hypothetical protein; Provisional; Region: PRK08185 436717005482 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose...; Region: TBP_aldolase_IIB; cd00947 436717005483 intersubunit interface [polypeptide binding]; other site 436717005484 active site 436717005485 zinc binding site [ion binding]; other site 436717005486 Na+ binding site [ion binding]; other site 436717005487 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cl00198 436717005488 substrate binding site [chemical binding]; other site 436717005489 hinge regions; other site 436717005490 ADP binding site [chemical binding]; other site 436717005491 catalytic site [active] 436717005492 Uncharacterized protein conserved in bacteria (DUF2237); Region: DUF2237; cl01467 436717005493 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 436717005494 active site 436717005495 dimer interface [polypeptide binding]; other site 436717005496 Cupin superfamily protein; Region: Cupin_4; pfam08007 436717005497 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 436717005498 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 436717005499 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 436717005500 dimerization interface [polypeptide binding]; other site 436717005501 putative DNA binding site [nucleotide binding]; other site 436717005502 putative Zn2+ binding site [ion binding]; other site 436717005503 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 436717005504 Protein of unknown function (DUF1275); Region: DUF1275; cl01453 436717005505 Uncharacterized protein conserved in bacteria (DUF2058); Region: DUF2058; cl01201 436717005506 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 436717005507 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 436717005508 MsbA is an essential ABC transporter, closely related to eukaryotic MDR proteins. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic...; Region: ABCC_MsbA; cd03251 436717005509 Walker A/P-loop; other site 436717005510 ATP binding site [chemical binding]; other site 436717005511 Q-loop/lid; other site 436717005512 ABC transporter signature motif; other site 436717005513 Walker B; other site 436717005514 D-loop; other site 436717005515 H-loop/switch region; other site 436717005516 YdeM is a Bacillus subtilis protein that belongs to a family of prokaryotic proteins of unkown function. YdeM has sequence similarity to the hot-dog fold of (R)-specific enoyl-CoA hydratase. Other enzymes with this fold include the peroxisomal...; Region: YdeM; cd03454 436717005517 putative active site [active] 436717005518 putative catalytic site [active] 436717005519 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 436717005520 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 436717005521 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 436717005522 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and L-...; Region: GCS_H; cd06848 436717005523 lipoyl attachment site [posttranslational modification]; other site 436717005524 SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes...; Region: SIRT5_Af1_CobB; cd01412 436717005525 NAD+ binding site [chemical binding]; other site 436717005526 substrate binding site [chemical binding]; other site 436717005527 Zn binding site [ion binding]; other site 436717005528 Sodium:solute symporter family; Region: SSF; cl00456 436717005529 leucine-responsive transcriptional regulator; Provisional; Region: PRK11169 436717005530 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 436717005531 bifunctional proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: PRK11905 436717005532 Proline dehydrogenase; Region: Pro_dh; cl03282 436717005533 Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125 436717005534 Glutamate binding site [chemical binding]; other site 436717005535 NAD binding site [chemical binding]; other site 436717005536 catalytic residues [active] 436717005537 Uncharacterised protein family (UPF0157); Region: UPF0157; cl00987 436717005538 tRNA (uracil-5-)-methyltransferase; Validated; Region: PRK05031 436717005539 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 436717005540 Predicted periplasmic protein (DUF2233); Region: DUF2233; cl10481 436717005541 NC domain; Region: NC; pfam04970 436717005542 YceI-like domain; Region: YceI; cl01001 436717005543 OsmC-like protein; Region: OsmC; cl00767 436717005544 transketolase; Reviewed; Region: PRK12753 436717005545 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 436717005546 TPP-binding site [chemical binding]; other site 436717005547 dimer interface [polypeptide binding]; other site 436717005548 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 436717005549 PYR/PP interface [polypeptide binding]; other site 436717005550 dimer interface [polypeptide binding]; other site 436717005551 TPP binding site [chemical binding]; other site 436717005552 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 436717005553 S-adenosylmethionine synthetase; Validated; Region: PRK05250 436717005554 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 436717005555 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 436717005556 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 436717005557 FxsA cytoplasmic membrane protein; Region: FxsA; cl01148 436717005558 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01039 436717005559 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 436717005560 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 436717005561 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 436717005562 non-specific DNA binding site [nucleotide binding]; other site 436717005563 salt bridge; other site 436717005564 sequence-specific DNA binding site [nucleotide binding]; other site 436717005565 Cupin domain; Region: Cupin_2; cl09118 436717005566 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cd00529 436717005567 active site 436717005568 putative DNA-binding cleft [nucleotide binding]; other site 436717005569 dimer interface [polypeptide binding]; other site 436717005570 putative carbohydrate kinase; Provisional; Region: PRK10565 436717005571 YjeF-related protein N-terminus; Region: YjeF_N; cl00318 436717005572 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 436717005573 putative substrate binding site [chemical binding]; other site 436717005574 putative ATP binding site [chemical binding]; other site 436717005575 Uncharacterized Fe-S protein [Energy production and conversion]; Region: COG1600 436717005576 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 436717005577 biotin synthase; Provisional; Region: PRK15108 436717005578 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 436717005579 FeS/SAM binding site; other site 436717005580 Biotin and Thiamin Synthesis associated domain; Region: BATS; cl06149 436717005581 Fimbrial protein; Region: Fimbrial; cl01416 436717005582 putative chaperone protein EcpD; Provisional; Region: PRK09926 436717005583 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 436717005584 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 436717005585 pilin outer membrane usher protein SafC; Provisional; Region: PRK15223; cl14650 436717005586 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 436717005587 putative major fimbrial protein SthE; Provisional; Region: PRK15292 436717005588 Fimbrial protein; Region: Fimbrial; cl01416 436717005589 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 436717005590 Helix-turn-helix domain; Region: HTH_18; pfam12833 436717005591 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 436717005592 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; cl01132 436717005593 Transcriptional regulator [Transcription]; Region: LysR; COG0583 436717005594 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 436717005595 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 436717005596 dimerization interface [polypeptide binding]; other site 436717005597 EamA-like transporter family; Region: EamA; cl01037 436717005598 Purine-cytosine permease and related proteins [Nucleotide transport and metabolism]; Region: CodB; COG1457 436717005599 Sodium:solute symporter family; Region: SSF; cl00456 436717005600 Predicted membrane protein [Function unknown]; Region: COG4125 436717005601 Bacterial Transmembrane Pair family; Region: BTP; pfam05232 436717005602 Bacterial Transmembrane Pair family; Region: BTP; pfam05232 436717005603 Transcriptional regulator [Transcription]; Region: LysR; COG0583 436717005604 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 436717005605 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 436717005606 dimerization interface [polypeptide binding]; other site 436717005607 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 436717005608 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 436717005609 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown ABO13168; Region: LPLAT_ABO13168-like; cd07988 436717005610 putative acyl-acceptor binding pocket; other site 436717005611 Domain of unknown function DUF28; Region: DUF28; cl00361 436717005612 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 436717005613 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 436717005614 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 436717005615 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP; Region: ABC_HisP_GlnQ_permeases; cd03262 436717005616 Walker A/P-loop; other site 436717005617 ATP binding site [chemical binding]; other site 436717005618 Q-loop/lid; other site 436717005619 ABC transporter signature motif; other site 436717005620 Walker B; other site 436717005621 D-loop; other site 436717005622 H-loop/switch region; other site 436717005623 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 436717005624 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 436717005625 dimer interface [polypeptide binding]; other site 436717005626 conserved gate region; other site 436717005627 putative PBP binding loops; other site 436717005628 ABC-ATPase subunit interface; other site 436717005629 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 436717005630 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 436717005631 dimer interface [polypeptide binding]; other site 436717005632 conserved gate region; other site 436717005633 putative PBP binding loops; other site 436717005634 ABC-ATPase subunit interface; other site 436717005635 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and...; Region: PBPb; cd00134 436717005636 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 436717005637 substrate binding pocket [chemical binding]; other site 436717005638 membrane-bound complex binding site; other site 436717005639 hinge residues; other site 436717005640 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 436717005641 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 436717005642 C-terminal domain interface [polypeptide binding]; other site 436717005643 GSH binding site (G-site) [chemical binding]; other site 436717005644 dimer interface [polypeptide binding]; other site 436717005645 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 436717005646 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 436717005647 active site 436717005648 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 436717005649 Dibenzothiophene (DBT) desulfurization enzyme C; Region: DszC; cd01163 436717005650 Flavin binding site [chemical binding]; other site 436717005651 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 436717005652 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 436717005653 active site 436717005654 non-prolyl cis peptide bond; other site 436717005655 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 436717005656 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 436717005657 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 436717005658 MetN (also known as YusC) is an ABC-type transporter encoded by metN of the metNPQ operon in Bacillus subtilis that is involved in methionine transport. Other members of this system include the MetP permease and the MetQ substrate binding protein; Region: ABC_MetN_methionine_transporter; cd03258 436717005659 Walker A/P-loop; other site 436717005660 ATP binding site [chemical binding]; other site 436717005661 Q-loop/lid; other site 436717005662 ABC transporter signature motif; other site 436717005663 Walker B; other site 436717005664 D-loop; other site 436717005665 H-loop/switch region; other site 436717005666 NIL domain; Region: NIL; pfam09383 436717005667 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 436717005668 dimer interface [polypeptide binding]; other site 436717005669 conserved gate region; other site 436717005670 ABC-ATPase subunit interface; other site 436717005671 GTP-binding protein YchF; Reviewed; Region: PRK09601 436717005672 YchF subfamily. YchF is a member of the Obg family, which includes four other subfamilies of GTPases: Obg, DRG, Ygr210, and NOG1. Obg is an essential gene that is involved in DNA replication in C. crescentus and Streptomyces griseus and is associated...; Region: YchF; cd01900 436717005673 G1 box; other site 436717005674 GTP/Mg2+ binding site [chemical binding]; other site 436717005675 Switch I region; other site 436717005676 G2 box; other site 436717005677 Switch II region; other site 436717005678 G3 box; other site 436717005679 G4 box; other site 436717005680 G5 box; other site 436717005681 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 436717005682 Protein of unknown function (DUF962); Region: DUF962; cl01879 436717005683 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 436717005684 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 436717005685 ligand binding site [chemical binding]; other site 436717005686 flexible hinge region; other site 436717005687 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 436717005688 putative switch regulator; other site 436717005689 non-specific DNA interactions [nucleotide binding]; other site 436717005690 DNA binding site [nucleotide binding] 436717005691 sequence specific DNA binding site [nucleotide binding]; other site 436717005692 putative cAMP binding site [chemical binding]; other site 436717005693 AzlC protein; Region: AzlC; cl00570 436717005694 putative L-valine exporter; Provisional; Region: PRK10408 436717005695 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 436717005696 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 436717005697 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 436717005698 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 436717005699 PII uridylyl-transferase; Provisional; Region: glnD; PRK00275 436717005700 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 436717005701 metal binding triad; other site 436717005702 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 436717005703 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 436717005704 ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900 436717005705 C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899 436717005706 aspartate aminotransferase; Provisional; Region: PRK08361 436717005707 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 436717005708 pyridoxal 5'-phosphate binding site [chemical binding]; other site 436717005709 homodimer interface [polypeptide binding]; other site 436717005710 catalytic residue [active] 436717005711 LysE type translocator; Region: LysE; cl00565 436717005712 Cupin domain; Region: Cupin_2; cl09118 436717005713 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 436717005714 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 436717005715 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue...; Region: GSH_Peroxidase; cd00340 436717005716 catalytic residues [active] 436717005717 dimer interface [polypeptide binding]; other site 436717005718 SelR domain; Region: SelR; cl00369 436717005719 alanine aminotransferase; Provisional; Region: PTZ00377 436717005720 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 436717005721 pyridoxal 5'-phosphate binding site [chemical binding]; other site 436717005722 homodimer interface [polypeptide binding]; other site 436717005723 catalytic residue [active] 436717005724 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 436717005725 Asparaginase (amidohydrolase): Asparaginases are tetrameric enzymes that catalyze the hydrolysis of asparagine to aspartic acid and ammonia. In bacteria, there are two classes of amidohydrolases, one highly specific for asparagine and localised to the...; Region: Asparaginase; cl00216 436717005726 active site/substrate binding site [active] 436717005727 tetramer interface [polypeptide binding]; other site 436717005728 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 436717005729 DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481 436717005730 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 436717005731 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli...; Region: DnaE_OBF; cd04485 436717005732 generic binding surface II; other site 436717005733 generic binding surface I; other site 436717005734 rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565 436717005735 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 436717005736 serine O-acetyltransferase; Region: cysE; TIGR01172 436717005737 Serine acetyltransferase, N-terminal; Region: SATase_N; pfam06426 436717005738 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of L-...; Region: LbH_SAT; cd03354 436717005739 trimer interface [polypeptide binding]; other site 436717005740 active site 436717005741 substrate binding site [chemical binding]; other site 436717005742 CoA binding site [chemical binding]; other site 436717005743 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 436717005744 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 436717005745 alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317 436717005746 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the...; Region: AhpF_NTD_N; cd02974 436717005747 catalytic residue [active] 436717005748 TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026 436717005749 catalytic residues [active] 436717005750 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 436717005751 Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059 436717005752 Chromate transporter; Region: Chromate_transp; pfam02417 436717005753 Chromate transporter; Region: Chromate_transp; pfam02417 436717005754 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 436717005755 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 436717005756 The C-terminal substrate binding domain of LysR-type transcrptional regulator BudR, which is responsible for activation of the expression of the butanediol operon genes; contains the type 2 periplasmic binding fold; Region: PBP2_BudR; cd08451 436717005757 putative dimerization interface [polypeptide binding]; other site 436717005758 putative substrate binding pocket [chemical binding]; other site 436717005759 Membrane transport protein; Region: Mem_trans; cl09117 436717005760 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 436717005761 dimerization interface [polypeptide binding]; other site 436717005762 putative DNA binding site [nucleotide binding]; other site 436717005763 putative Zn2+ binding site [ion binding]; other site 436717005764 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 436717005765 catalytic residues [active] 436717005766 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 436717005767 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 436717005768 active site 436717005769 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them...; Region: YcaC_related; cd01012 436717005770 Isochorismatase family; Region: Isochorismatase; pfam00857 436717005771 catalytic triad [active] 436717005772 dimer interface [polypeptide binding]; other site 436717005773 conserved cis-peptide bond; other site 436717005774 Transcriptional regulator [Transcription]; Region: LysR; COG0583 436717005775 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 436717005776 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 436717005777 putative effector binding pocket; other site 436717005778 dimerization interface [polypeptide binding]; other site 436717005779 Transcriptional regulators [Transcription]; Region: GntR; COG1802 436717005780 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 436717005781 DNA-binding site [nucleotide binding]; DNA binding site 436717005782 FCD domain; Region: FCD; cl11656 436717005783 Sodium:solute symporter family; Region: SSF; cl00456 436717005784 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 436717005785 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG...; Region: CAS_like; cl00184 436717005786 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 436717005787 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 436717005788 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 436717005789 dimer interface [polypeptide binding]; other site 436717005790 conserved gate region; other site 436717005791 putative PBP binding loops; other site 436717005792 ABC-ATPase subunit interface; other site 436717005793 taurine transporter ATP-binding subunit; Provisional; Region: tauB; PRK11248 436717005794 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars...; Region: ABC_NrtD_SsuB_transporters; cd03293 436717005795 Walker A/P-loop; other site 436717005796 ATP binding site [chemical binding]; other site 436717005797 Q-loop/lid; other site 436717005798 ABC transporter signature motif; other site 436717005799 Walker B; other site 436717005800 D-loop; other site 436717005801 H-loop/switch region; other site 436717005802 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 436717005803 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and...; Region: PBPb; cd00134 436717005804 substrate binding pocket [chemical binding]; other site 436717005805 membrane-bound complex binding site; other site 436717005806 hinge residues; other site 436717005807 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 436717005808 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 436717005809 putative substrate translocation pore; other site 436717005810 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 436717005811 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 436717005812 active site 436717005813 non-prolyl cis peptide bond; other site 436717005814 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 436717005815 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 436717005816 active site 436717005817 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562 436717005818 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 436717005819 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 436717005820 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 436717005821 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 436717005822 DNA-binding site [nucleotide binding]; DNA binding site 436717005823 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 436717005824 pyridoxal 5'-phosphate binding site [chemical binding]; other site 436717005825 homodimer interface [polypeptide binding]; other site 436717005826 catalytic residue [active] 436717005827 Transcriptional regulator [Transcription]; Region: LysR; COG0583 436717005828 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 436717005829 The C-terminal substrate-binding domian of LysR-type transcriptional regulator MdcR, which involved in the malonate catabolism contains the type 2 periplasmic binding fold; Region: PBP2_MdcR; cd08416 436717005830 putative dimerization interface [polypeptide binding]; other site 436717005831 Malonate/sodium symporter MadM subunit; Region: MadM; cl04274 436717005832 Malonate transporter MadL subunit; Region: MadL; cl04273 436717005833 Acyl transferase domain; Region: Acyl_transf_1; cl08282 436717005834 malonate decarboxylase, epsilon subunit; Region: malonate_mdcH; TIGR03131 436717005835 Phosphoribosyl-dephospho-CoA transferase MdcG; Region: MdcG; cl07913 436717005836 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl00513 436717005837 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl00513 436717005838 Malonate decarboxylase delta subunit (MdcD); Region: ACP; cl06082 436717005839 ATP:dephospho-CoA triphosphoribosyl transferase; Region: CitG; cl00768 436717005840 malonate decarboxylase, alpha subunit; Region: mdcA; TIGR01110 436717005841 Major Facilitator Superfamily; Region: MFS_1; pfam07690 436717005842 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 436717005843 putative substrate translocation pore; other site 436717005844 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 436717005845 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 436717005846 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 436717005847 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 436717005848 DNA-binding site [nucleotide binding]; DNA binding site 436717005849 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 436717005850 pyridoxal 5'-phosphate binding site [chemical binding]; other site 436717005851 homodimer interface [polypeptide binding]; other site 436717005852 catalytic residue [active] 436717005853 LrgB-like family; Region: LrgB; cl00596 436717005854 LrgA family; Region: LrgA; cl00608 436717005855 Transcriptional regulator [Transcription]; Region: LysR; COG0583 436717005856 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 436717005857 The C-terminal substrate binding domain of LysR-like transcriptional regulator CidR, contains the type 2 periplasmic binding fold; Region: PBP2_CidR; cd08438 436717005858 putative dimerization interface [polypeptide binding]; other site 436717005859 glutathione S-transferase; Provisional; Region: PRK15113 436717005860 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 436717005861 C-terminal domain interface [polypeptide binding]; other site 436717005862 GSH binding site (G-site) [chemical binding]; other site 436717005863 dimer interface [polypeptide binding]; other site 436717005864 GST_C family, unknown subfamily 4; composed of uncharacterized proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous...; Region: GST_C_4; cd03195 436717005865 putative substrate binding pocket (H-site) [chemical binding]; other site 436717005866 putative N-terminal domain interface [polypeptide binding]; other site 436717005867 putative S-transferase; Provisional; Region: PRK11752 436717005868 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen...; Region: GST_N_Ure2p_like; cd03048 436717005869 C-terminal domain interface [polypeptide binding]; other site 436717005870 GSH binding site (G-site) [chemical binding]; other site 436717005871 dimer interface [polypeptide binding]; other site 436717005872 GST_C family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen...; Region: GST_C_Ure2p_like; cd03178 436717005873 dimer interface [polypeptide binding]; other site 436717005874 N-terminal domain interface [polypeptide binding]; other site 436717005875 putative substrate binding pocket (H-site) [chemical binding]; other site 436717005876 Protein of unknown function (DUF2000); Region: DUF2000; cl02074 436717005877 LysE type translocator; Region: LysE; cl00565 436717005878 Cupin domain; Region: Cupin_2; cl09118 436717005879 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 436717005880 Transcriptional regulator [Transcription]; Region: LysR; COG0583 436717005881 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 436717005882 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 436717005883 putative effector binding pocket; other site 436717005884 putative dimerization interface [polypeptide binding]; other site 436717005885 short chain dehydrogenase; Provisional; Region: PRK12937 436717005886 tetrahydroxynaphthalene/trihydroxynaphthalene reductase-like, classical (c) SDRs; Region: THN_reductase-like_SDR_c; cd05362 436717005887 NADP binding site [chemical binding]; other site 436717005888 homodimer interface [polypeptide binding]; other site 436717005889 active site 436717005890 substrate binding site [chemical binding]; other site 436717005891 Member of the Rhodanese Homology Domain superfamily, subgroup 1. This CD includes the putative rhodanese-related sulfurtransferases of several uncharacterized proteins; Region: RHOD_1; cd01522 436717005892 active site residue [active] 436717005893 serine acetyltransferase; Region: PLN02357 436717005894 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of L-...; Region: LbH_SAT; cd03354 436717005895 trimer interface [polypeptide binding]; other site 436717005896 active site 436717005897 substrate binding site [chemical binding]; other site 436717005898 CoA binding site [chemical binding]; other site 436717005899 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 436717005900 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 436717005901 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 436717005902 catalytic residue [active] 436717005903 LysE type translocator; Region: LysE; cl00565 436717005904 transcriptional activator TtdR; Provisional; Region: PRK09801 436717005905 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 436717005906 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 436717005907 putative effector binding pocket; other site 436717005908 dimerization interface [polypeptide binding]; other site 436717005909 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 436717005910 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and...; Region: PBPb; cd00134 436717005911 substrate binding pocket [chemical binding]; other site 436717005912 membrane-bound complex binding site; other site 436717005913 hinge residues; other site 436717005914 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 436717005915 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and...; Region: PBPb; cd00134 436717005916 substrate binding pocket [chemical binding]; other site 436717005917 membrane-bound complex binding site; other site 436717005918 hinge residues; other site 436717005919 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 436717005920 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP; Region: ABC_HisP_GlnQ_permeases; cd03262 436717005921 Walker A/P-loop; other site 436717005922 ATP binding site [chemical binding]; other site 436717005923 Q-loop/lid; other site 436717005924 ABC transporter signature motif; other site 436717005925 Walker B; other site 436717005926 D-loop; other site 436717005927 H-loop/switch region; other site 436717005928 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 436717005929 dimer interface [polypeptide binding]; other site 436717005930 conserved gate region; other site 436717005931 putative PBP binding loops; other site 436717005932 ABC-ATPase subunit interface; other site 436717005933 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 436717005934 dimer interface [polypeptide binding]; other site 436717005935 conserved gate region; other site 436717005936 putative PBP binding loops; other site 436717005937 ABC-ATPase subunit interface; other site 436717005938 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 436717005939 ribonucleoside transporter; Reviewed; Region: nepI; PRK10213 436717005940 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 436717005941 putative substrate translocation pore; other site 436717005942 Transcriptional regulator [Transcription]; Region: LysR; COG0583 436717005943 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 436717005944 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 436717005945 putative effector binding pocket; other site 436717005946 putative dimerization interface [polypeptide binding]; other site 436717005947 Domain of unknown function (DUF369); Region: DUF369; cl00950 436717005948 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 436717005949 Response regulator receiver domain; Region: Response_reg; pfam00072 436717005950 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 436717005951 active site 436717005952 phosphorylation site [posttranslational modification] 436717005953 intermolecular recognition site; other site 436717005954 dimerization interface [polypeptide binding]; other site 436717005955 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 436717005956 DNA binding residues [nucleotide binding] 436717005957 dimerization interface [polypeptide binding]; other site 436717005958 Purine-cytosine permease and related proteins [Nucleotide transport and metabolism]; Region: CodB; COG1457 436717005959 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 436717005960 dimer interface [polypeptide binding]; other site 436717005961 phosphorylation site [posttranslational modification] 436717005962 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 436717005963 ATP binding site [chemical binding]; other site 436717005964 Mg2+ binding site [ion binding]; other site 436717005965 G-X-G motif; other site 436717005966 Response regulator receiver domain; Region: Response_reg; pfam00072 436717005967 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 436717005968 active site 436717005969 phosphorylation site [posttranslational modification] 436717005970 intermolecular recognition site; other site 436717005971 dimerization interface [polypeptide binding]; other site 436717005972 Purine-cytosine permease and related proteins [Nucleotide transport and metabolism]; Region: CodB; COG1457 436717005973 Sodium:solute symporter family; Region: SSF; cl00456 436717005974 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 436717005975 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 436717005976 LysE type translocator; Region: LysE; cl00565 436717005977 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (...; Region: S24_LexA-like; cd06529 436717005978 Catalytic site [active] 436717005979 short chain dehydrogenase; Provisional; Region: PRK06701 436717005980 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 436717005981 NAD binding site [chemical binding]; other site 436717005982 metal binding site [ion binding]; metal-binding site 436717005983 active site 436717005984 hydroperoxidase II; Provisional; Region: katE; PRK11249 436717005985 Clade 2 of the heme-binding enzyme catalase; Region: catalase_clade_2; cd08155 436717005986 tetramer interface [polypeptide binding]; other site 436717005987 heme binding pocket [chemical binding]; other site 436717005988 Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132 436717005989 domain interactions; other site 436717005990 Competence-damaged protein; Region: CinA; cl00666 436717005991 Transcriptional regulator [Transcription]; Region: LysR; COG0583 436717005992 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 436717005993 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 436717005994 putative effector binding pocket; other site 436717005995 dimerization interface [polypeptide binding]; other site 436717005996 SGNH_hydrolase subfamily, similar to the putative arylesterase/acylhydrolase from the rumen anaerobe Prevotella bryantii XynE. The P. bryantii XynE gene is located in a xylanase gene cluster. SGNH hydrolases are a diverse family of lipases and...; Region: XynE_like; cd01830 436717005997 active site 436717005998 catalytic triad [active] 436717005999 oxyanion hole [active] 436717006000 benzoate transport; Region: 2A0115; TIGR00895 436717006001 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 436717006002 putative substrate translocation pore; other site 436717006003 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16...; Region: OM_channels; cl00284 436717006004 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 436717006005 S-adenosylmethionine binding site [chemical binding]; other site 436717006006 AMP-binding domain protein; Validated; Region: PRK08315 436717006007 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 436717006008 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 436717006009 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 436717006010 isovaleryl-CoA dehydrogenase; Region: PLN02519 436717006011 Isovaleryl-CoA dehydrogenase; Region: IVD; cd01156 436717006012 substrate binding site [chemical binding]; other site 436717006013 FAD binding site [chemical binding]; other site 436717006014 catalytic base [active] 436717006015 3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820 436717006016 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl00513 436717006017 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl00513 436717006018 enoyl-CoA hydratase; Provisional; Region: PRK05995 436717006019 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 436717006020 substrate binding site [chemical binding]; other site 436717006021 oxyanion hole (OAH) forming residues; other site 436717006022 trimer interface [polypeptide binding]; other site 436717006023 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 436717006024 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 436717006025 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 436717006026 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 436717006027 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase...; Region: biotinyl_domain; cd06850 436717006028 carboxyltransferase (CT) interaction site; other site 436717006029 biotinylation site [posttranslational modification]; other site 436717006030 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 436717006031 active site 436717006032 catalytic residues [active] 436717006033 metal binding site [ion binding]; metal-binding site 436717006034 transcriptional regulator; Provisional; Region: PRK10632 436717006035 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 436717006036 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 436717006037 putative effector binding pocket; other site 436717006038 dimerization interface [polypeptide binding]; other site 436717006039 indolepyruvate ferredoxin oxidoreductase; Validated; Region: PRK09193 436717006040 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 436717006041 dimer interface [polypeptide binding]; other site 436717006042 PYR/PP interface [polypeptide binding]; other site 436717006043 TPP binding site [chemical binding]; other site 436717006044 substrate binding site [chemical binding]; other site 436717006045 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin...; Region: TPP_enzymes; cl01629 436717006046 TPP-binding site [chemical binding]; other site 436717006047 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546 436717006048 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 436717006049 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 436717006050 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 436717006051 active site 436717006052 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 436717006053 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 436717006054 CoenzymeA binding site [chemical binding]; other site 436717006055 subunit interaction site [polypeptide binding]; other site 436717006056 PHB binding site; other site 436717006057 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 436717006058 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 436717006059 putative substrate translocation pore; other site 436717006060 Coenzyme A transferase; Region: CoA_trans; cl00773 436717006061 Coenzyme A transferase; Region: CoA_trans; cl00773 436717006062 benzoate transport; Region: 2A0115; TIGR00895 436717006063 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 436717006064 putative substrate translocation pore; other site 436717006065 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 436717006066 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 436717006067 active site 436717006068 enoyl-CoA hydratase; Provisional; Region: PRK08138 436717006069 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 436717006070 substrate binding site [chemical binding]; other site 436717006071 oxyanion hole (OAH) forming residues; other site 436717006072 trimer interface [polypeptide binding]; other site 436717006073 3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826 436717006074 classical (c) SDRs; Region: SDR_c; cd05233 436717006075 NAD(P) binding site [chemical binding]; other site 436717006076 active site 436717006077 3-hydroxy-acyl-CoA dehydrogenase; Validated; Region: PRK08268 436717006078 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 436717006079 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 436717006080 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 436717006081 acetyl-CoA acetyltransferase; Provisional; Region: PRK08131 436717006082 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 436717006083 dimer interface [polypeptide binding]; other site 436717006084 active site 436717006085 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 436717006086 Transcriptional regulator [Transcription]; Region: IclR; COG1414 436717006087 Bacterial transcriptional regulator; Region: IclR; pfam01614 436717006088 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 436717006089 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 436717006090 putative substrate translocation pore; other site 436717006091 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 436717006092 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin...; Region: NPD_like; cd04730 436717006093 FMN binding site [chemical binding]; other site 436717006094 substrate binding site [chemical binding]; other site 436717006095 putative catalytic residue [active] 436717006096 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 436717006097 enoyl-CoA hydratase; Provisional; Region: PRK06688 436717006098 substrate binding site [chemical binding]; other site 436717006099 oxyanion hole (OAH) forming residues; other site 436717006100 trimer interface [polypeptide binding]; other site 436717006101 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 436717006102 Transcriptional regulator [Transcription]; Region: IclR; COG1414 436717006103 Bacterial transcriptional regulator; Region: IclR; pfam01614 436717006104 CoA-transferase family III; Region: CoA_transf_3; cl00778 436717006105 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 436717006106 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 436717006107 active site 436717006108 benzoate transport; Region: 2A0115; TIGR00895 436717006109 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 436717006110 putative substrate translocation pore; other site 436717006111 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 436717006112 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 436717006113 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 436717006114 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 436717006115 catalytic residue [active] 436717006116 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 436717006117 FAD dependent oxidoreductase TIGR03364; Region: HpnW_proposed 436717006118 potential frameshift: common BLAST hit: gi|126641408|ref|YP_001084392.1| ABC-type Fe3+ transport system permease component 436717006119 putative 2-aminoethylphosphonate ABC transporter, ATP-binding protein; Region: PhnT2; TIGR03265 436717006120 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 436717006121 Walker A/P-loop; other site 436717006122 ATP binding site [chemical binding]; other site 436717006123 Q-loop/lid; other site 436717006124 ABC transporter signature motif; other site 436717006125 Walker B; other site 436717006126 D-loop; other site 436717006127 H-loop/switch region; other site 436717006128 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 436717006129 ABC-type thiamine transport system, periplasmic component [Coenzyme metabolism]; Region: TbpA; COG4143 436717006130 transcriptional regulator protein; Region: phnR; TIGR03337 436717006131 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 436717006132 DNA-binding site [nucleotide binding]; DNA binding site 436717006133 UTRA domain; Region: UTRA; cl06649 436717006134 4-hydroxybenzoate 3-monooxygenase; Validated; Region: PRK08243 436717006135 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 436717006136 beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Region: pcaR_pcaU; TIGR02431 436717006137 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 436717006138 Bacterial transcriptional regulator; Region: IclR; pfam01614 436717006139 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 436717006140 Transcriptional regulator [Transcription]; Region: LysR; COG0583 436717006141 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 436717006142 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_6; cd08475 436717006143 putative effector binding pocket; other site 436717006144 putative dimerization interface [polypeptide binding]; other site 436717006145 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 436717006146 Uncharacterized ACR, COG1469; Region: DUF198; cl00642 436717006147 Gamma carbonic anhydrases (CA): Carbonic anhydrases are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism, involving the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide...; Region: LbH_gamma_CA; cd00710 436717006148 trimer interface [polypeptide binding]; other site 436717006149 active site 436717006150 dihydroorotase; Reviewed; Region: PRK09236 436717006151 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have...; Region: metallo-dependent_hydrolases; cl00281 436717006152 Dihydroorotase (DHOase), subgroup IIb; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This group contains the archeal members of the DHOase family; Region: DHOase_IIb; cd01318 436717006153 active site 436717006154 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 436717006155 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 436717006156 Serine dehydratase alpha chain; Region: SDH_alpha; cl12120 436717006157 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 436717006158 Transmembrane amino acid transporter protein; Region: Aa_trans; cl00524 436717006159 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 436717006160 Alpha-Ketoglutaric Semialdehyde Dehydrogenase; Region: ALDH_KGSADH; cd07129 436717006161 dimer interface [polypeptide binding]; other site 436717006162 NADP binding site [chemical binding]; other site 436717006163 catalytic residues [active] 436717006164 metabolite-proton symporter; Region: 2A0106; TIGR00883 436717006165 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 436717006166 putative substrate translocation pore; other site 436717006167 PAS fold; Region: PAS_4; pfam08448 436717006168 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 436717006169 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 436717006170 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 436717006171 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl14614 436717006172 A subunit; Region: glycerol3P_GlpA; TIGR03377 436717006173 Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383 436717006174 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 436717006175 Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl14881 436717006176 Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl14881 436717006177 hydroxyproline-2-epimerase; Provisional; Region: PRK13970 436717006178 hydroxyproline-2-epimerase; Provisional; Region: PRK13971 436717006179 Transcriptional regulators [Transcription]; Region: GntR; COG1802 436717006180 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 436717006181 DNA-binding site [nucleotide binding]; DNA binding site 436717006182 FCD domain; Region: FCD; cl11656 436717006183 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 436717006184 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 436717006185 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 436717006186 inhibitor site; inhibition site 436717006187 active site 436717006188 dimer interface [polypeptide binding]; other site 436717006189 catalytic residue [active] 436717006190 Putative hemolysin [General function prediction only]; Region: Hlx; COG3042 436717006191 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 436717006192 Domain of unknown function (DUF333); Region: DUF333; pfam03891 436717006193 Peptidase inhibitor I78 family; Region: Inhibitor_I78; pfam11720 436717006194 redox-sensitive transcriptional activator SoxR; Region: SoxR; TIGR01950 436717006195 Helix-Turn-Helix DNA binding domain of the SoxR transcription regulator; Region: HTH_SoxR; cd01110 436717006196 DNA binding residues [nucleotide binding] 436717006197 dimer interface [polypeptide binding]; other site 436717006198 [2Fe-2S] cluster binding site [ion binding]; other site 436717006199 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1636 436717006200 Uncharacterized BCR, COG1636; Region: DUF208; pfam02677 436717006201 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 436717006202 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 436717006203 DNA-binding site [nucleotide binding]; DNA binding site 436717006204 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 436717006205 pyridoxal 5'-phosphate binding site [chemical binding]; other site 436717006206 homodimer interface [polypeptide binding]; other site 436717006207 catalytic residue [active] 436717006208 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 436717006209 Coenzyme A binding pocket [chemical binding]; other site 436717006210 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214 436717006211 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 436717006212 putative cyanate transporter; Provisional; Region: cynX; PRK09705 436717006213 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 436717006214 nucleoside/Zn binding site; other site 436717006215 dimer interface [polypeptide binding]; other site 436717006216 catalytic motif [active] 436717006217 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 436717006218 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 436717006219 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 436717006220 Transcriptional regulator [Transcription]; Region: LysR; COG0583 436717006221 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 436717006222 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 436717006223 D-alanyl-D-alanine carboxypeptidase; Region: VanY; cl00813 436717006224 Uncharacterized protein conserved in bacteria (DUF2077); Region: DUF2077; cl01370 436717006225 Bacterial protein of unknown function (DUF876); Region: DUF876; cl01406 436717006226 type VI secretion-associated protein, ImpA family; Region: VI_chp_8; TIGR03363 436717006227 ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812 436717006228 type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345 436717006229 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 436717006230 Walker A motif; other site 436717006231 ATP binding site [chemical binding]; other site 436717006232 Walker B motif; other site 436717006233 arginine finger; other site 436717006234 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 436717006235 Walker A motif; other site 436717006236 ATP binding site [chemical binding]; other site 436717006237 Walker B motif; other site 436717006238 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 436717006239 Uncharacterized conserved protein [Function unknown]; Region: COG4104 436717006240 Flagellar motor protein [Cell motility and secretion]; Region: MotB; COG1360 436717006241 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 436717006242 ligand binding site [chemical binding]; other site 436717006243 Uncharacterized protein conserved in bacteria (DUF2094); Region: DUF2094; cl01611 436717006244 Type VI protein secretion system component VasK [Intracellular trafficking, secretion, and vesicular transport]; Region: IcmF; COG3523 436717006245 Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761 436717006246 Protein of unknown function (DUF1215); Region: DUF1215; pfam06744 436717006247 Protein of unknown function (DUF1305); Region: DUF1305; cl01404 436717006248 Bacterial protein of unknown function (DUF879); Region: DUF879; pfam05947 436717006249 type VI secretion protein, VC_A0110 family; Region: VI_chp_6; TIGR03359 436717006250 Gene 25-like lysozyme; Region: GPW_gp25; cl01403 436717006251 Protein of unknown function (DUF796); Region: DUF796; cl01226 436717006252 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3517; cl05484 436717006253 Protein of unknown function (DUF877); Region: DUF877; pfam05943 436717006254 Protein of unknown function (DUF770); Region: DUF770; cl01402 436717006255 Sel1 repeat; Region: Sel1; cl02723 436717006256 Sel1 repeat; Region: Sel1; cl02723 436717006257 Sel1 repeat; Region: Sel1; cl02723 436717006258 Sel1 repeat; Region: Sel1; cl02723 436717006259 Sel1 repeat; Region: Sel1; cl02723 436717006260 Uncharacterized protein conserved in bacteria [Function unknown]; Region: VgrG; COG3501 436717006261 Phage-related baseplate assembly protein; Region: Phage_base_V; cl11432 436717006262 Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; cl01733 436717006263 RHS protein; Region: RHS; pfam03527 436717006264 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 436717006265 Domain of unknown function (DUF1910); Region: DUF1910; pfam08928 436717006266 Domain of unknown function (DUF1911); Region: DUF1911; pfam08929 436717006267 Uncharacterized protein conserved in bacteria [Function unknown]; Region: VgrG; COG3501 436717006268 Phage-related baseplate assembly protein; Region: Phage_base_V; cl11432 436717006269 Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; cl01733 436717006270 Transcriptional regulator [Transcription]; Region: LysR; COG0583 436717006271 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 436717006272 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 436717006273 putative effector binding pocket; other site 436717006274 dimerization interface [polypeptide binding]; other site 436717006275 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 436717006276 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 436717006277 putative substrate translocation pore; other site 436717006278 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4460 436717006279 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 436717006280 dimer interface [polypeptide binding]; other site 436717006281 conserved gate region; other site 436717006282 putative PBP binding loops; other site 436717006283 ABC-ATPase subunit interface; other site 436717006284 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 436717006285 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars...; Region: ABC_NrtD_SsuB_transporters; cd03293 436717006286 Walker A/P-loop; other site 436717006287 ATP binding site [chemical binding]; other site 436717006288 Q-loop/lid; other site 436717006289 ABC transporter signature motif; other site 436717006290 Walker B; other site 436717006291 D-loop; other site 436717006292 H-loop/switch region; other site 436717006293 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 436717006294 allophanate hydrolase; Provisional; Region: PRK08186 436717006295 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl11426 436717006296 nickel responsive regulator; Provisional; Region: PRK04460 436717006297 NikR C terminal nickel binding domain; Region: NikR_C; pfam08753 436717006298 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 436717006299 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 436717006300 urea carboxylase; Region: urea_carbox; TIGR02712 436717006301 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 436717006302 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 436717006303 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 436717006304 Allophanate hydrolase subunit 2; Region: AHS2; cl00865 436717006305 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896 436717006306 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase...; Region: biotinyl_domain; cd06850 436717006307 carboxyltransferase (CT) interaction site; other site 436717006308 biotinylation site [posttranslational modification]; other site 436717006309 Domain of unknown function (DUF1989); Region: DUF1989; cl01474 436717006310 Domain of unknown function (DUF1989); Region: DUF1989; cl01474 436717006311 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 436717006312 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 436717006313 NAD binding site [chemical binding]; other site 436717006314 catalytic Zn binding site [ion binding]; other site 436717006315 structural Zn binding site [ion binding]; other site 436717006316 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07066 436717006317 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 436717006318 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 436717006319 aromatic amino acid exporter; Provisional; Region: PRK11689 436717006320 EamA-like transporter family; Region: EamA; cl01037 436717006321 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 436717006322 putative hydrophobic ligand binding site [chemical binding]; other site 436717006323 protein interface [polypeptide binding]; other site 436717006324 gate; other site 436717006325 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 436717006326 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 436717006327 ClC sycA-like chloride channel proteins. This ClC family presents in bacteria, where it facilitates acid resistance in acidic soil. Mutation of this gene (sycA) in Rhizobium tropici CIAT899 causes serious deficiencies in nodule development, nodulation...; Region: ClC_sycA_like; cd03682 436717006328 Voltage gated chloride channel; Region: Voltage_CLC; pfam00654 436717006329 putative Cl- selectivity filter; other site 436717006330 putative pore gating glutamate residue; other site 436717006331 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 436717006332 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 436717006333 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 436717006334 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 436717006335 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase...; Region: biotinyl_domain; cd06850 436717006336 carboxyltransferase (CT) interaction site; other site 436717006337 biotinylation site [posttranslational modification]; other site 436717006338 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 436717006339 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896 436717006340 Allophanate hydrolase subunit 2; Region: AHS2; cl00865 436717006341 Allophanate hydrolase subunit 2; Region: AHS2; pfam02626 436717006342 Protein of unknown function (DUF1445); Region: DUF1445; cl01790 436717006343 LamB/YcsF family; Region: LamB_YcsF; cl00664 436717006344 Natural resistance-associated macrophage protein; Region: Nramp; cl00836 436717006345 Transcriptional regulator [Transcription]; Region: LysR; COG0583 436717006346 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 436717006347 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 436717006348 dimerization interface [polypeptide binding]; other site 436717006349 RNA polymerase sigma factor; Provisional; Region: PRK12544 436717006350 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 436717006351 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171 436717006352 DNA binding residues [nucleotide binding] 436717006353 Uncharacterized protein conserved in bacteria (DUF2063); Region: DUF2063; cl01262 436717006354 hypothetical protein; Provisional; Region: PRK05409 436717006355 Protein of unknown function (DUF692); Region: DUF692; cl01263 436717006356 DoxX; Region: DoxX; cl00976 436717006357 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 436717006358 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 436717006359 NAD(P) binding site [chemical binding]; other site 436717006360 active site 436717006361 Beta-lactamase; Region: Beta-lactamase; cl01009 436717006362 Carbohydrate-selective porin [Cell envelope biogenesis, outer membrane]; Region: OprB; COG3659 436717006363 Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966 436717006364 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 436717006365 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 436717006366 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 436717006367 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 436717006368 Transcriptional regulator [Transcription]; Region: LysR; COG0583 436717006369 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 436717006370 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 436717006371 putative effector binding pocket; other site 436717006372 putative dimerization interface [polypeptide binding]; other site 436717006373 Hydrolase of X-linked nucleoside diphosphate N terminal; Region: Nudix_N; pfam12535 436717006374 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_14; cd04672 436717006375 nudix motif; other site 436717006376 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 436717006377 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 436717006378 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 436717006379 AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582 436717006380 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 436717006381 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 436717006382 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 436717006383 PAP2, bacterial acid phosphatase or class A non-specific acid phosphatases. These enzymes catalyze phosphomonoester hydrolysis, with optimal activity in low pH conditions. They are secreted into the periplasmic space, and their physiological role...; Region: PAP2_acid_phosphatase; cd03397 436717006384 active site 436717006385 AIDA autotransporter-like protein ShdA; Provisional; Region: PRK15319 436717006386 Pertactin-like passenger domains (virulence factors) of autotransporter proteins of the type V secretion system. Autotransporters are proteins used by Gram-negative bacteria to transport proteins across their outer membranes. The C-terminal (beta)...; Region: PL_Passenger_AT; cl00185 436717006387 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 436717006388 RNA polymerase sigma factor; Provisional; Region: PRK12528 436717006389 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 436717006390 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171 436717006391 DNA binding residues [nucleotide binding] 436717006392 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 436717006393 FecR protein; Region: FecR; pfam04773 436717006394 Outer membrane receptor for ferric coprogen and ferric-rhodotorulic acid [Inorganic ion transport and metabolism]; Region: FhuE; COG4773 436717006395 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 436717006396 N-terminal plug; other site 436717006397 ligand-binding site [chemical binding]; other site 436717006398 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 436717006399 tetramer interface [polypeptide binding]; other site 436717006400 active site 436717006401 Mg2+/Mn2+ binding site [ion binding]; other site 436717006402 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 436717006403 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 436717006404 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 436717006405 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 436717006406 N-terminal plug; other site 436717006407 ligand-binding site [chemical binding]; other site 436717006408 Spore Coat Protein U domain; Region: SCPU; cl02253 436717006409 Uncharacterized protein conserved in bacteria (DUF2147); Region: DUF2147; cl01951 436717006410 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 436717006411 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and...; Region: PBPb; cd00134 436717006412 substrate binding pocket [chemical binding]; other site 436717006413 membrane-bound complex binding site; other site 436717006414 hinge residues; other site 436717006415 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 436717006416 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 436717006417 dimer interface [polypeptide binding]; other site 436717006418 conserved gate region; other site 436717006419 putative PBP binding loops; other site 436717006420 ABC-ATPase subunit interface; other site 436717006421 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 436717006422 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars...; Region: ABC_NrtD_SsuB_transporters; cd03293 436717006423 Walker A/P-loop; other site 436717006424 ATP binding site [chemical binding]; other site 436717006425 Q-loop/lid; other site 436717006426 ABC transporter signature motif; other site 436717006427 Walker B; other site 436717006428 D-loop; other site 436717006429 H-loop/switch region; other site 436717006430 D-cysteine desulfhydrase; Validated; Region: PRK03910 436717006431 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD)...; Region: Trp-synth-beta_II; cl00342 436717006432 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 436717006433 catalytic residue [active] 436717006434 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 436717006435 aspartate racemase; Region: asp_race; TIGR00035 436717006436 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 436717006437 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 436717006438 putative substrate translocation pore; other site 436717006439 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 436717006440 active site 436717006441 catalytic residues [active] 436717006442 metal binding site [ion binding]; metal-binding site 436717006443 CoA-transferase family III; Region: CoA_transf_3; cl00778 436717006444 Transcriptional regulator [Transcription]; Region: LysR; COG0583 436717006445 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 436717006446 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_1; cd08421 436717006447 putative dimerization interface [polypeptide binding]; other site 436717006448 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria...; Region: Cytochrome_b_N; cl00859 436717006449 Catalase-like heme-binding proteins similar to the uncharacterized srpA; Region: srpA_like; cd08153 436717006450 putative heme binding pocket [chemical binding]; other site 436717006451 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 436717006452 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 436717006453 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein...; Region: CSP_CDS; cd04458 436717006454 DNA-binding site [nucleotide binding]; DNA binding site 436717006455 RNA-binding motif; other site 436717006456 Threonine/homoserine efflux transporter [Amino acid transport and metabolism]; Region: rhtA; COG5006 436717006457 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 436717006458 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 436717006459 ethanolamine permease; Region: 2A0305; TIGR00908 436717006460 Transmembrane amino acid transporter protein; Region: Aa_trans; cl00524 436717006461 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 436717006462 active site 436717006463 substrate binding site [chemical binding]; other site 436717006464 Phosphotransferase enzyme family; Region: APH; pfam01636 436717006465 ATP binding site [chemical binding]; other site 436717006466 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 436717006467 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 436717006468 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 436717006469 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 436717006470 4-aminobutyrate aminotransferase and related aminotransferases [Amino acid transport and metabolism]; Region: GabT; COG0160 436717006471 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase...; Region: OAT_like; cd00610 436717006472 inhibitor-cofactor binding pocket; inhibition site 436717006473 pyridoxal 5'-phosphate binding site [chemical binding]; other site 436717006474 catalytic residue [active] 436717006475 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 436717006476 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 436717006477 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; cl00304 436717006478 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl02184 436717006479 H+ Antiporter protein; Region: 2A0121; TIGR00900 436717006480 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 436717006481 CoenzymeA binding site [chemical binding]; other site 436717006482 subunit interaction site [polypeptide binding]; other site 436717006483 PHB binding site; other site 436717006484 phenylacetic acid degradation protein PaaY; Region: PaaY; TIGR02287 436717006485 paaY-like: This group is composed by uncharacterized proteins with similarity to the protein product of the E. coli paaY gene, which is part of the paa gene cluster responsible for phenylacetic acid degradation. Proteins in this group are expected to...; Region: LbH_paaY_like; cd04745 436717006486 putative trimer interface [polypeptide binding]; other site 436717006487 putative metal binding site [ion binding]; other site 436717006488 PaaX-like protein; Region: PaaX; pfam07848 436717006489 phenylacetic acid degradation operon negative regulatory protein PaaX; Region: PaaX_trns_reg; TIGR02277 436717006490 PaaX-like protein C-terminal domain; Region: PaaX_C; pfam08223 436717006491 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 436717006492 beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050 436717006493 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 436717006494 dimer interface [polypeptide binding]; other site 436717006495 active site 436717006496 3-hydroxy-acyl-CoA dehydrogenase; Validated; Region: PRK08268 436717006497 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 436717006498 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 436717006499 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 436717006500 enoyl-CoA hydratase; Provisional; Region: PRK08140 436717006501 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 436717006502 substrate binding site [chemical binding]; other site 436717006503 oxyanion hole (OAH) forming residues; other site 436717006504 trimer interface [polypeptide binding]; other site 436717006505 enoyl-CoA hydratase-isomerase; Provisional; Region: PRK09674 436717006506 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 436717006507 substrate binding site [chemical binding]; other site 436717006508 oxyanion hole (OAH) forming residues; other site 436717006509 trimer interface [polypeptide binding]; other site 436717006510 phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160 436717006511 NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-...; Region: PA_degradation_oxidoreductase_like; cd06214 436717006512 FAD binding pocket [chemical binding]; other site 436717006513 FAD binding motif [chemical binding]; other site 436717006514 phosphate binding motif [ion binding]; other site 436717006515 beta-alpha-beta structure motif; other site 436717006516 NAD(p) ribose binding residues [chemical binding]; other site 436717006517 NAD binding pocket [chemical binding]; other site 436717006518 NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site 436717006519 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 436717006520 catalytic loop [active] 436717006521 iron binding site [ion binding]; other site 436717006522 Domain of unknown function DUF59; Region: DUF59; cl00941 436717006523 phenylacetate-CoA oxygenase, PaaJ subunit; Region: PA_CoA_Oxy4; TIGR02159 436717006524 Phenylacetic acid catabolic protein; Region: PaaA_PaaC; cl01346 436717006525 Phenylacetic acid degradation B; Region: PaaB; cl01371 436717006526 Phenylacetic acid catabolic protein; Region: PaaA_PaaC; cl01346 436717006527 phenylacetate-CoA oxygenase, PaaG subunit; Region: PA_CoA_Oxy1; TIGR02156 436717006528 bifunctional aldehyde dehydrogenase/enoyl-CoA hydratase; Provisional; Region: PRK11563 436717006529 N-terminal domain of the monoamine oxidase C dehydratase; Region: ALDH_MaoC-N; cd07128 436717006530 substrate binding site [chemical binding]; other site 436717006531 dimer interface [polypeptide binding]; other site 436717006532 NADP binding site [chemical binding]; other site 436717006533 catalytic residues [active] 436717006534 MaoC_C The C-terminal hot dog fold of the MaoC (monoamine oxidase C) dehydratase regulatory protein. Orthologs of MaoC include PaaZ [Escherichia coli] and PaaN [Pseudomonas putida], which are putative ring-opening enzymes involved in phenylacetic acid...; Region: MaoC_C; cd03452 436717006535 substrate binding site [chemical binding]; other site 436717006536 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 436717006537 putative substrate translocation pore; other site 436717006538 Transcriptional regulator [Transcription]; Region: LysR; COG0583 436717006539 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 436717006540 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 436717006541 putative effector binding pocket; other site 436717006542 dimerization interface [polypeptide binding]; other site 436717006543 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 436717006544 MutS domain I; Region: MutS_I; pfam01624 436717006545 MutS domain II; Region: MutS_II; pfam05188 436717006546 MutS family domain IV; Region: MutS_IV; pfam05190 436717006547 MutS1 homolog in eukaryotes. The MutS protein initiates DNA mismatch repair by recognizing mispaired and unpaired bases embedded in duplex DNA and activating endo- and exonucleases to remove the mismatch. Members of the MutS family possess C-terminal...; Region: ABC_MutS1; cd03284 436717006548 Walker A/P-loop; other site 436717006549 ATP binding site [chemical binding]; other site 436717006550 Q-loop/lid; other site 436717006551 ABC transporter signature motif; other site 436717006552 Walker B; other site 436717006553 D-loop; other site 436717006554 H-loop/switch region; other site 436717006555 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 436717006556 Coenzyme A binding pocket [chemical binding]; other site 436717006557 Ferredoxin [Energy production and conversion]; Region: COG1146 436717006558 Domain of unknown function (DUF3470); Region: DUF3470; pfam11953 436717006559 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3108 436717006560 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 436717006561 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 436717006562 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 436717006563 Ligand Binding Site [chemical binding]; other site 436717006564 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cd00208 436717006565 putative trimer interface [polypeptide binding]; other site 436717006566 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the 6-...; Region: LbH_MAT_like; cd04647 436717006567 trimer interface [polypeptide binding]; other site 436717006568 active site 436717006569 substrate binding site [chemical binding]; other site 436717006570 putative CoA binding site [chemical binding]; other site 436717006571 CoA binding site [chemical binding]; other site 436717006572 Uncharacterized conserved protein [Function unknown]; Region: COG1739 436717006573 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 436717006574 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 436717006575 type I secretion system ATPase, LssB family; Region: type_I_sec_LssB; TIGR03375 436717006576 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 436717006577 ABC-type bacteriocin exporters. Many non-lantibiotic bacteriocins of lactic acid bacteria are produced as precursors which have N-terminal leader peptides that share similarities in amino acid sequence and contain a conserved processing site of two...; Region: ABCC_bacteriocin_exporters; cd03245 436717006578 Walker A/P-loop; other site 436717006579 ATP binding site [chemical binding]; other site 436717006580 Q-loop/lid; other site 436717006581 ABC transporter signature motif; other site 436717006582 Walker B; other site 436717006583 D-loop; other site 436717006584 H-loop/switch region; other site 436717006585 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 436717006586 Outer membrane efflux protein; Region: OEP; pfam02321 436717006587 Outer membrane efflux protein; Region: OEP; pfam02321 436717006588 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 436717006589 The ABC transporters belonging to the YhbG family are similar to members of the Mj1267_LivG family, which is involved in the transport of branched-chain amino acids. The genes yhbG and yhbN are located in a single operon and may function together in...; Region: ABC_YhbG; cd03218 436717006590 Walker A/P-loop; other site 436717006591 ATP binding site [chemical binding]; other site 436717006592 Q-loop/lid; other site 436717006593 ABC transporter signature motif; other site 436717006594 Walker B; other site 436717006595 D-loop; other site 436717006596 H-loop/switch region; other site 436717006597 OstA-like protein; Region: OstA; cl00844 436717006598 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3117; cl01200 436717006599 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 436717006600 D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892 436717006601 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose 5-...; Region: SIS_Kpsf; cd05014 436717006602 putative active site [active] 436717006603 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 436717006604 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 436717006605 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 436717006606 active site 436717006607 HIGH motif; other site 436717006608 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 436717006609 KMSKS motif; other site 436717006610 Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963 436717006611 tRNA binding surface [nucleotide binding]; other site 436717006612 anticodon binding site; other site 436717006613 Preprotein translocase subunit SecB. SecB is a cytoplasmic component of the multisubunit membrane-bound enzyme termed Sec protein translocase, which is the main constituent of the General Secretory (type II) Pathway involved in translocation of nascent...; Region: Translocase_SecB; cl00251 436717006614 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 436717006615 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 436717006616 Major Facilitator Superfamily; Region: MFS_1; pfam07690 436717006617 putative substrate translocation pore; other site 436717006618 Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4705 436717006619 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 436717006620 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 436717006621 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 436717006622 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 436717006623 Old yellow enzyme (OYE)-related FMN binding domain, group 2. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_2_FMN; cd04733 436717006624 putative active site [active] 436717006625 putative FMN binding site [chemical binding]; other site 436717006626 putative substrate binding site [chemical binding]; other site 436717006627 putative catalytic residue [active] 436717006628 short chain dehydrogenase; Validated; Region: PRK05855 436717006629 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 436717006630 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687 436717006631 Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118 436717006632 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 436717006633 Mechanosensitive ion channel; Region: MS_channel; pfam00924 436717006634 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 436717006635 active site 436717006636 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 436717006637 S-adenosylmethionine binding site [chemical binding]; other site 436717006638 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 436717006639 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 436717006640 active site 436717006641 Uncharacterized protein conserved in bacteria (DUF2171); Region: DUF2171; cl01558 436717006642 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 436717006643 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687 436717006644 Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118 436717006645 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 436717006646 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 436717006647 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 436717006648 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 436717006649 S-adenosylmethionine binding site [chemical binding]; other site 436717006650 leucine-responsive transcriptional regulator; Provisional; Region: PRK11169 436717006651 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 436717006652 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 436717006653 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 436717006654 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein...; Region: CSP_CDS; cd04458 436717006655 DNA-binding site [nucleotide binding]; DNA binding site 436717006656 RNA-binding motif; other site 436717006657 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 436717006658 putative acyl-acceptor binding pocket; other site 436717006659 LysE type translocator; Region: LysE; cl00565 436717006660 Predicted lysozyme (DUF847); Region: DUF847; pfam05838 436717006661 Predicted Peptidoglycan domain; Region: PG_binding_3; pfam09374 436717006662 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 436717006663 non-specific DNA binding site [nucleotide binding]; other site 436717006664 salt bridge; other site 436717006665 Predicted transcriptional regulator [Transcription]; Region: COG2932 436717006666 sequence-specific DNA binding site [nucleotide binding]; other site 436717006667 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (...; Region: S24_LexA-like; cd06529 436717006668 Catalytic site [active] 436717006669 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 436717006670 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a single-strand-...; Region: ExoVII_LU_OBF; cd04489 436717006671 generic binding surface II; other site 436717006672 generic binding surface I; other site 436717006673 LysE type translocator; Region: LysE; cl00565 436717006674 Cysteine-rich 4 helical bundle widely conserved in bacteria; Region: DUF326; cd08026 436717006675 dimerization interface [polypeptide binding]; other site 436717006676 Glutathione-dependent formaldehyde-activating enzyme; Region: GFA; cl01553 436717006677 Cu(I)-responsive transcriptional regulator; Region: CueR; TIGR02044 436717006678 Helix-Turn-Helix DNA binding domain of CueR-like transcription regulators; Region: HTH_CueR; cd01108 436717006679 DNA binding residues [nucleotide binding] 436717006680 dimer interface [polypeptide binding]; other site 436717006681 copper binding site [ion binding]; other site 436717006682 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 436717006683 metal-binding site [ion binding] 436717006684 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 436717006685 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 436717006686 metal-binding site [ion binding] 436717006687 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 436717006688 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 436717006689 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cl00207 436717006690 Activator of aromatic catabolism; Region: XylR_N; pfam06505 436717006691 V4R domain; Region: V4R; cl08369 436717006692 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 436717006693 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 436717006694 Walker A motif; other site 436717006695 ATP binding site [chemical binding]; other site 436717006696 Walker B motif; other site 436717006697 arginine finger; other site 436717006698 Phenol hydroxylase subunit; Region: Phenol_hyd_sub; pfam06099 436717006699 Aromatic and Alkene Monooxygenase Hydroxylase, subunit B, ferritin-like diiron-binding domain; Region: AAMH_B; cd01058 436717006700 dimerization interface [polypeptide binding]; other site 436717006701 MmoB/DmpM family; Region: MmoB_DmpM; pfam02406 436717006702 Aromatic and Alkene Monooxygenase Hydroxylase, subunit A, ferritin-like diiron-binding domain; Region: AAMH_A; cd01057 436717006703 dimerization interface [polypeptide binding]; other site 436717006704 putative path to active site cavity [active] 436717006705 diiron center [ion binding]; other site 436717006706 Phenol hydroxylase conserved region; Region: Phenol_monoox; pfam04663 436717006707 CDP-6-deoxy-delta-3,4-glucoseen reductase; Validated; Region: PRK07609 436717006708 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 436717006709 catalytic loop [active] 436717006710 iron binding site [ion binding]; other site 436717006711 Phenol 2-monooxygenase (phenol hydroxylase) is a flavoprotein monooxygenase, able to use molecular oxygen as a substrate in the microbial degredation of phenol. This protein is encoded by a single gene and uses a tightly bound FAD cofactor in the NAD(P); Region: phenol_2-monooxygenase_like; cd06211 436717006712 FAD binding pocket [chemical binding]; other site 436717006713 FAD binding motif [chemical binding]; other site 436717006714 phosphate binding motif [ion binding]; other site 436717006715 beta-alpha-beta structure motif; other site 436717006716 NAD binding pocket [chemical binding]; other site 436717006717 Protein involved in meta-pathway of phenol degradation [Energy production and conversion]; Region: COG4313 436717006718 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 436717006719 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 436717006720 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 436717006721 dimerization interface [polypeptide binding]; other site 436717006722 benzoate 1,2-dioxygenase, large subunit; Region: benzo_1_2_benA; TIGR03229 436717006723 Rieske non-heme iron oxygenase (RO) family, 2-Halobenzoate 1,2-dioxygenase (HBDO) subfamily, N-terminal Rieske domain of the oxygenase alpha subunit; ROs comprise a large class of aromatic ring-hydroxylating dioxygenases that enable microorganisms to...; Region: Rieske_RO_Alpha_HBDO; cd03542 436717006724 C-terminal catalytic domain of the oxygenase alpha subunit of Pseudomonas resinovorans strain CA10 anthranilate 1,2-dioxygenase and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_AntDO-like; cd08879 436717006725 putative alpha subunit interface [polypeptide binding]; other site 436717006726 putative active site [active] 436717006727 putative substrate binding site [chemical binding]; other site 436717006728 Fe binding site [ion binding]; other site 436717006729 Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667 436717006730 inter-subunit interface; other site 436717006731 anthranilate dioxygenase reductase; Provisional; Region: antC; PRK11872 436717006732 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 436717006733 catalytic loop [active] 436717006734 iron binding site [ion binding]; other site 436717006735 Benzoate dioxygenase reductase (BenDO) FAD/NAD binding domain. Oxygenases oxidize hydrocarbons using dioxygen as the oxidant. As a Class I bacterial dioxygenases, benzoate dioxygenase like proteins combine an [2Fe-2S] cluster containing N-terminal...; Region: BenDO_FAD_NAD; cd06209 436717006736 FAD binding pocket [chemical binding]; other site 436717006737 FAD binding motif [chemical binding]; other site 436717006738 phosphate binding motif [ion binding]; other site 436717006739 beta-alpha-beta structure motif; other site 436717006740 NAD binding pocket [chemical binding]; other site 436717006741 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 436717006742 1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate dehydrogenase (DHB DH)-like, classical (c) SDR; Region: DHB_DH-like_SDR_c; cd08937 436717006743 putative NAD(P) binding site [chemical binding]; other site 436717006744 active site 436717006745 benzoate transporter; Region: benE; TIGR00843 436717006746 Sulfate transporter family; Region: Sulfate_transp; cl00967 436717006747 benzoate transport; Region: 2A0115; TIGR00895 436717006748 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 436717006749 putative substrate translocation pore; other site 436717006750 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 436717006751 putative substrate translocation pore; other site 436717006752 outer membrane porin, OprD family; Region: OprD; pfam03573 436717006753 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK07515 436717006754 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 436717006755 dimer interface [polypeptide binding]; other site 436717006756 active site 436717006757 CoA binding pocket [chemical binding]; other site 436717006758 ATP-dependent helicase HrpA; Region: DEAH_box_HrpA; TIGR01967 436717006759 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 436717006760 ATP binding site [chemical binding]; other site 436717006761 putative Mg++ binding site [ion binding]; other site 436717006762 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 436717006763 nucleotide binding region [chemical binding]; other site 436717006764 ATP-binding site [chemical binding]; other site 436717006765 Helicase associated domain (HA2); Region: HA2; cl04503 436717006766 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 436717006767 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 436717006768 peroxiredoxin; Region: AhpC; TIGR03137 436717006769 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic...; Region: PRX_Typ2cys; cd03015 436717006770 dimer interface [polypeptide binding]; other site 436717006771 decamer (pentamer of dimers) interface [polypeptide binding]; other site 436717006772 catalytic triad [active] 436717006773 peroxidatic and resolving cysteines [active] 436717006774 Alkane hydroxylase is a bacterial, integral-membrane di-iron enzyme that shares a requirement for iron and oxygen for activity similar to that of the non-heme integral-membrane acyl coenzyme A (CoA) desaturases and acyl lipid desaturases. The alk genes...; Region: Alkane-hydroxylase; cd03512 436717006775 Fatty acid desaturase; Region: FA_desaturase; pfam00487 436717006776 Di-iron ligands [ion binding]; other site 436717006777 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 436717006778 Helix-turn-helix domain; Region: HTH_18; pfam12833 436717006779 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 436717006780 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 436717006781 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 436717006782 S-adenosylmethionine binding site [chemical binding]; other site 436717006783 Protein of unknown function (DUF1653); Region: DUF1653; cl01949 436717006784 alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317 436717006785 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the...; Region: AhpF_NTD_N; cd02974 436717006786 catalytic residue [active] 436717006787 TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026 436717006788 catalytic residues [active] 436717006789 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 436717006790 glutathionine S-transferase; Provisional; Region: PRK10542 436717006791 GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens...; Region: GST_N_Beta; cd03057 436717006792 C-terminal domain interface [polypeptide binding]; other site 436717006793 GSH binding site (G-site) [chemical binding]; other site 436717006794 dimer interface [polypeptide binding]; other site 436717006795 GST_C family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens...; Region: GST_C_Beta; cd03188 436717006796 dimer interface [polypeptide binding]; other site 436717006797 N-terminal domain interface [polypeptide binding]; other site 436717006798 substrate binding pocket (H-site) [chemical binding]; other site 436717006799 Predicted extracellular nuclease [General function prediction only]; Region: COG2374 436717006800 YhcR_OBF_like: A subfamily of OB-fold domains similar to the OB folds of Bacillus subtilis YhcR. YhcR is a sugar-nonspecific nuclease, which is active in the presence of Ca2+ and Mn2+. It cleaves RNA endonucleolytically, producing 3'-monophosphate...; Region: YhcR_OBF_like; cd04486 436717006801 generic binding surface II; other site 436717006802 generic binding surface I; other site 436717006803 Mycoplasma pulmonis MnuA nuclease-like; Region: MnuA_DNase1-like; cd10283 436717006804 putative active site [active] 436717006805 putative catalytic site [active] 436717006806 putative Mg binding site IVb [ion binding]; other site 436717006807 putative phosphate binding site [ion binding]; other site 436717006808 putative DNA binding site [nucleotide binding]; other site 436717006809 putative Mg binding site IVa [ion binding]; other site 436717006810 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 436717006811 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; cl00614 436717006812 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 436717006813 GST_N family, unknown subfamily 2; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_2; cd03047 436717006814 putative C-terminal domain interface [polypeptide binding]; other site 436717006815 putative GSH binding site (G-site) [chemical binding]; other site 436717006816 putative dimer interface [polypeptide binding]; other site 436717006817 GST_C family, unknown subfamily 2; composed of uncharacterized bacterial proteins, with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_C_2; cd03180 436717006818 putative N-terminal domain interface [polypeptide binding]; other site 436717006819 putative dimer interface [polypeptide binding]; other site 436717006820 putative substrate binding pocket (H-site) [chemical binding]; other site 436717006821 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 436717006822 Domain of unknown function (DUF2520); Region: DUF2520; pfam10728 436717006823 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 436717006824 ligand binding site [chemical binding]; other site 436717006825 dihydroorotase; Validated; Region: pyrC; PRK09357 436717006826 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C...; Region: DHOase_IIa; cd01317 436717006827 active site 436717006828 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 436717006829 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 436717006830 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 436717006831 23S rRNA m(2)G2445 methyltransferase; Provisional; Region: rlmL; PRK11783 436717006832 THUMP domain; Region: THUMP; cl12076 436717006833 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 436717006834 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 436717006835 Competence-damaged protein; Region: CinA; cl00666 436717006836 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 436717006837 Clp amino terminal domain; Region: Clp_N; pfam02861 436717006838 Clp amino terminal domain; Region: Clp_N; pfam02861 436717006839 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 436717006840 Walker A motif; other site 436717006841 ATP binding site [chemical binding]; other site 436717006842 Walker B motif; other site 436717006843 arginine finger; other site 436717006844 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 436717006845 Walker A motif; other site 436717006846 ATP binding site [chemical binding]; other site 436717006847 Walker B motif; other site 436717006848 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 436717006849 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 436717006850 Peptidase family M23; Region: Peptidase_M23; pfam01551 436717006851 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 436717006852 Coenzyme A binding pocket [chemical binding]; other site 436717006853 OsmC-like protein; Region: OsmC; cl00767 436717006854 DNA-binding transcriptional dual regulator Crp; Provisional; Region: PRK11753 436717006855 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 436717006856 ligand binding site [chemical binding]; other site 436717006857 flexible hinge region; other site 436717006858 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 436717006859 putative switch regulator; other site 436717006860 non-specific DNA interactions [nucleotide binding]; other site 436717006861 DNA binding site [nucleotide binding] 436717006862 sequence specific DNA binding site [nucleotide binding]; other site 436717006863 putative cAMP binding site [chemical binding]; other site 436717006864 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 436717006865 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and...; Region: Aldo_ket_red; cd06660 436717006866 active site 436717006867 catalytic tetrad [active] 436717006868 Peptidase family M48; Region: Peptidase_M48; cl12018 436717006869 adenylosuccinate synthetase; Provisional; Region: PRK01117 436717006870 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 436717006871 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 436717006872 ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: PRK12421 436717006873 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: HisRS-like_core; cd00773 436717006874 dimer interface [polypeptide binding]; other site 436717006875 motif 1; other site 436717006876 active site 436717006877 motif 2; other site 436717006878 motif 3; other site 436717006879 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 436717006880 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 436717006881 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 436717006882 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 436717006883 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation...; Region: AlaRS_core; cd00673 436717006884 motif 1; other site 436717006885 active site 436717006886 motif 2; other site 436717006887 motif 3; other site 436717006888 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 436717006889 DHHA1 domain; Region: DHHA1; pfam02272 436717006890 aspartate kinase; Reviewed; Region: PRK06635 436717006891 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 436717006892 putative nucleotide binding site [chemical binding]; other site 436717006893 putative catalytic residues [active] 436717006894 putative Mg ion binding site [ion binding]; other site 436717006895 putative aspartate binding site [chemical binding]; other site 436717006896 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 436717006897 putative allosteric regulatory site; other site 436717006898 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 436717006899 Global regulator protein family; Region: CsrA; cl00670 436717006900 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 436717006901 RNA/DNA hybrid binding site [nucleotide binding]; other site 436717006902 active site 436717006903 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria...; Region: Cytochrome_b_N; cl00859 436717006904 Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320 436717006905 active site 436717006906 purine riboside binding site [chemical binding]; other site 436717006907 Sulfate transporter family; Region: Sulfate_transp; cl00967 436717006908 Permease family; Region: Xan_ur_permease; pfam00860 436717006909 Pirin-related protein [General function prediction only]; Region: COG1741 436717006910 Cupin domain; Region: Cupin_2; cl09118 436717006911 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 436717006912 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 436717006913 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687 436717006914 Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118 436717006915 classical (c) SDRs; Region: SDR_c; cd05233 436717006916 short chain dehydrogenase; Provisional; Region: PRK05650 436717006917 NAD(P) binding site [chemical binding]; other site 436717006918 active site 436717006919 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 436717006920 Leucine carboxyl methyltransferase; Region: LCM; cl01306 436717006921 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 436717006922 transcriptional activator TtdR; Provisional; Region: PRK09801 436717006923 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_9; cd08479 436717006924 putative effector binding pocket; other site 436717006925 putative dimerization interface [polypeptide binding]; other site 436717006926 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 436717006927 D-galactonate transporter; Region: 2A0114; TIGR00893 436717006928 putative substrate translocation pore; other site 436717006929 Fumarate hydratase (Fumerase); Region: Fumerase; cl00851 436717006930 Fumarase C-terminus; Region: Fumerase_C; cl00795 436717006931 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 436717006932 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 436717006933 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 436717006934 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 436717006935 short chain dehydrogenase; Provisional; Region: PRK06181 436717006936 classical (c) SDRs; Region: SDR_c; cd05233 436717006937 NAD(P) binding site [chemical binding]; other site 436717006938 active site 436717006939 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 436717006940 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 436717006941 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 436717006942 TIGR03549 family protein; Region: TIGR03549 436717006943 OsmC-like protein; Region: OsmC; cl00767 436717006944 YcaO-like family; Region: YcaO; cl09146 436717006945 outer membrane porin, OprD family; Region: OprD; pfam03573 436717006946 benzoate transport; Region: 2A0115; TIGR00895 436717006947 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 436717006948 putative substrate translocation pore; other site 436717006949 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 436717006950 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 436717006951 Sulfatase; Region: Sulfatase; cl10460 436717006952 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; cl00556 436717006953 outer membrane porin, OprD family; Region: OprD; pfam03573 436717006954 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 436717006955 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1)...; Region: Rieske; cl00938 436717006956 iron-sulfur cluster [ion binding]; other site 436717006957 [2Fe-2S] cluster binding site [ion binding]; other site 436717006958 C-terminal catalytic domain of the oxygenase alpha subunit of dicamba O-demethylase and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_DMO-like; cd08878 436717006959 alpha subunit interface [polypeptide binding]; other site 436717006960 active site 436717006961 substrate binding site [chemical binding]; other site 436717006962 Fe binding site [ion binding]; other site 436717006963 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 436717006964 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-...; Region: PDR_like; cd06185 436717006965 FMN-binding pocket [chemical binding]; other site 436717006966 flavin binding motif; other site 436717006967 phosphate binding motif [ion binding]; other site 436717006968 beta-alpha-beta structure motif; other site 436717006969 NAD binding pocket [chemical binding]; other site 436717006970 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 436717006971 catalytic loop [active] 436717006972 iron binding site [ion binding]; other site 436717006973 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 436717006974 DNA-binding site [nucleotide binding]; DNA binding site 436717006975 FCD domain; Region: FCD; cl11656 436717006976 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 436717006977 putative 3-hydroxyphenylpropionic transporter MhpT; Provisional; Region: PRK11551 436717006978 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 436717006979 putative substrate translocation pore; other site 436717006980 p-hydroxycinnamoyl CoA hydratase/lyase; Validated; Region: PRK09120 436717006981 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 436717006982 substrate binding site [chemical binding]; other site 436717006983 oxyanion hole (OAH) forming residues; other site 436717006984 trimer interface [polypeptide binding]; other site 436717006985 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 436717006986 Salicylaldehyde dehydrogenase, DoxF-like; Region: ALDH_SaliADH; cd07105 436717006987 NAD(P) binding site [chemical binding]; other site 436717006988 catalytic residues [active] 436717006989 feruloyl-CoA synthase; Reviewed; Region: PRK08180 436717006990 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 436717006991 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 436717006992 active site 436717006993 outer membrane porin, OprD family; Region: OprD; pfam03573 436717006994 Protein of unknown function (DUF3237); Region: DUF3237; cl07905 436717006995 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 436717006996 CoenzymeA binding site [chemical binding]; other site 436717006997 subunit interaction site [polypeptide binding]; other site 436717006998 PHB binding site; other site 436717006999 Tannase and feruloyl esterase; Region: Tannase; pfam07519 436717007000 Transcriptional regulators [Transcription]; Region: FadR; COG2186 436717007001 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 436717007002 DNA-binding site [nucleotide binding]; DNA binding site 436717007003 FCD domain; Region: FCD; cl11656 436717007004 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 436717007005 Alpha-Ketoglutaric Semialdehyde Dehydrogenase; Region: ALDH_KGSADH; cd07129 436717007006 dimer interface [polypeptide binding]; other site 436717007007 NADP binding site [chemical binding]; other site 436717007008 catalytic residues [active] 436717007009 5-dehydro-4-deoxyglucarate dehydratase, also called 5-keto-4-deoxy-glucarate dehydratase (KDGDH); Region: KDGDH; cd00951 436717007010 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 436717007011 putative active site [active] 436717007012 catalytic residue [active] 436717007013 glucarate dehydratase; Region: glucar-dehydr; TIGR03247 436717007014 D-Glucarate dehydratase (GlucD) catalyzes the dehydration of both D-glucarate and L-idarate to form 5-keto-4-deoxy-D-glucarate (5-KDG) , the initial reaction of the catabolic pathway for (D)-glucarate. GlucD belongs to the enolase superfamily of...; Region: D-glucarate_dehydratase; cd03323 436717007015 active site 436717007016 tetramer interface [polypeptide binding]; other site 436717007017 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 436717007018 D-galactonate transporter; Region: 2A0114; TIGR00893 436717007019 putative substrate translocation pore; other site 436717007020 galactarate dehydratase; Region: galactar-dH20; TIGR03248 436717007021 SAF domain; Region: SAF; cl00555 436717007022 SAF domain; Region: SAF; cl00555 436717007023 EamA-like transporter family; Region: EamA; cl01037 436717007024 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 436717007025 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 436717007026 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 436717007027 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 436717007028 Coniferyl aldehyde dehydrogenase-like; Region: ALDH_CALDH_CalB; cd07133 436717007029 NAD(P) binding site [chemical binding]; other site 436717007030 catalytic residues [active] 436717007031 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 436717007032 haemagglutination activity domain; Region: Haemagg_act; cl05436 436717007033 Possible hemagglutinin (DUF637); Region: DUF637; pfam04830 436717007034 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520 436717007035 Surface antigen; Region: Bac_surface_Ag; cl03097 436717007036 Transmembrane amino acid transporter protein; Region: Aa_trans; cl00524 436717007037 Amino acid permease; Region: AA_permease; pfam00324 436717007038 Arginine/ornithine N-succinyltransferase beta subunit [Amino acid transport and metabolism]; Region: AstA; COG3138 436717007039 Arginine N-succinyltransferase beta subunit; Region: AstA; cl11440 436717007040 bifunctional succinylornithine transaminase/acetylornithine transaminase; Provisional; Region: PRK12381 436717007041 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase...; Region: OAT_like; cd00610 436717007042 inhibitor-cofactor binding pocket; inhibition site 436717007043 pyridoxal 5'-phosphate binding site [chemical binding]; other site 436717007044 catalytic residue [active] 436717007045 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 436717007046 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 436717007047 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 436717007048 Escherichia coli NAD+-dependent gamma-aminobutyraldehyde dehydrogenase YdcW-like; Region: ALDH_ABALDH-YdcW; cd07092 436717007049 tetrameric interface [polypeptide binding]; other site 436717007050 NAD binding site [chemical binding]; other site 436717007051 catalytic residues [active] 436717007052 substrate binding site [chemical binding]; other site 436717007053 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 436717007054 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 436717007055 Transcriptional regulators [Transcription]; Region: FadR; COG2186 436717007056 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 436717007057 DNA-binding site [nucleotide binding]; DNA binding site 436717007058 FCD domain; Region: FCD; cl11656 436717007059 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 436717007060 Transmembrane amino acid transporter protein; Region: Aa_trans; cl00524 436717007061 Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl14881 436717007062 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 436717007063 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 436717007064 Transmembrane amino acid transporter protein; Region: Aa_trans; cl00524 436717007065 Uncharacterized conserved protein (DUF2235); Region: DUF2235; cl01480 436717007066 Uncharacterized protein conserved in bacteria [Function unknown]; Region: VgrG; COG3501 436717007067 Phage-related baseplate assembly protein; Region: Phage_base_V; cl11432 436717007068 Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; cl01733 436717007069 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 436717007070 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 436717007071 Bacterial protein of unknown function (DUF898); Region: DUF898; cl01738 436717007072 Peptidase family M48; Region: Peptidase_M48; cl12018 436717007073 FAD binding domain; Region: FAD_binding_3; pfam01494 436717007074 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 436717007075 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 436717007076 phenol 2-monooxygenase; Provisional; Region: PRK08294 436717007077 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 436717007078 2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930 436717007079 active site 436717007080 FMN binding site [chemical binding]; other site 436717007081 2,4-decadienoyl-CoA binding site; other site 436717007082 catalytic residue [active] 436717007083 4Fe-4S cluster binding site [ion binding]; other site 436717007084 dihydropyrimidine dehydrogenase subunit A; Provisional; Region: PRK11749 436717007085 nitrite reductase [NAD(P)H], large subunit; Region: nitri_red_nirB; TIGR02374 436717007086 argininosuccinate synthase; Region: argG; TIGR00032 436717007087 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 436717007088 ANP binding site [chemical binding]; other site 436717007089 Substrate Binding Site II [chemical binding]; other site 436717007090 Substrate Binding Site I [chemical binding]; other site 436717007091 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 436717007092 metal binding site [ion binding]; metal-binding site 436717007093 active site 436717007094 I-site; other site 436717007095 Dihydroorotase [Nucleotide transport and metabolism]; Region: PyrC; COG0418 436717007096 Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294 436717007097 active site 436717007098 substrate binding pocket [chemical binding]; other site 436717007099 dimer interface [polypeptide binding]; other site 436717007100 DEDDh 3'-5' exonuclease domain of RNase T; Region: RNaseT; cd06134 436717007101 dimer interface [polypeptide binding]; other site 436717007102 putative active site [active] 436717007103 putative substrate binding site [chemical binding]; other site 436717007104 catalytic site [active] 436717007105 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 436717007106 putative active site [active] 436717007107 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 436717007108 Old yellow enzyme (OYE)-related FMN binding domain, group 2. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_2_FMN; cd04733 436717007109 putative active site [active] 436717007110 putative FMN binding site [chemical binding]; other site 436717007111 putative substrate binding site [chemical binding]; other site 436717007112 putative catalytic residue [active] 436717007113 ABC-type uncharacterized transport system, duplicated ATPase component [General function prediction only]; Region: COG4172 436717007114 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 436717007115 Walker A/P-loop; other site 436717007116 ATP binding site [chemical binding]; other site 436717007117 Q-loop/lid; other site 436717007118 ABC transporter signature motif; other site 436717007119 Walker B; other site 436717007120 D-loop; other site 436717007121 H-loop/switch region; other site 436717007122 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 436717007123 Walker A/P-loop; other site 436717007124 ATP binding site [chemical binding]; other site 436717007125 Q-loop/lid; other site 436717007126 ABC transporter signature motif; other site 436717007127 Walker B; other site 436717007128 D-loop; other site 436717007129 H-loop/switch region; other site 436717007130 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4239 436717007131 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 436717007132 dimer interface [polypeptide binding]; other site 436717007133 conserved gate region; other site 436717007134 putative PBP binding loops; other site 436717007135 ABC-ATPase subunit interface; other site 436717007136 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 436717007137 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 436717007138 dimer interface [polypeptide binding]; other site 436717007139 conserved gate region; other site 436717007140 putative PBP binding loops; other site 436717007141 ABC-ATPase subunit interface; other site 436717007142 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497 436717007143 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 436717007144 membrane-bound lytic murein transglycosylase D; Provisional; Region: mltD; PRK10783 436717007145 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 436717007146 N-acetyl-D-glucosamine binding site [chemical binding]; other site 436717007147 catalytic residue [active] 436717007148 stage VI sporulation protein D; Region: spore_VI_D; TIGR02907 436717007149 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cl00107 436717007150 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cl00107 436717007151 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 436717007152 putative peptidoglycan binding site; other site 436717007153 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cl00107 436717007154 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 436717007155 putative peptidoglycan binding site; other site 436717007156 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 436717007157 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 436717007158 putative peptidoglycan binding site; other site 436717007159 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 436717007160 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 436717007161 putative peptidoglycan binding site; other site 436717007162 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 436717007163 putative peptidoglycan binding site; other site 436717007164 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 436717007165 RNA/DNA hybrid binding site [nucleotide binding]; other site 436717007166 active site 436717007167 Proteobacterial; Region: dnaQ_proteo; TIGR01406 436717007168 DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131 436717007169 active site 436717007170 substrate binding site [chemical binding]; other site 436717007171 catalytic site [active] 436717007172 NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296 436717007173 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 436717007174 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 436717007175 putative NADH binding site [chemical binding]; other site 436717007176 putative active site [active] 436717007177 nudix motif; other site 436717007178 putative metal binding site [ion binding]; other site 436717007179 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 436717007180 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 436717007181 substrate binding pocket [chemical binding]; other site 436717007182 Predicted periplasmic or secreted lipoprotein [General function prediction only]; Region: OsmY; COG2823 436717007183 BON domain; Region: BON; cl02771 436717007184 Uncharacterised protein family UPF0102; Region: UPF0102; cl00516 436717007185 Predicted methyltransferases [General function prediction only]; Region: COG0313 436717007186 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; cl00304 436717007187 chromosome replication initiation inhibitor protein; Validated; Region: PRK03635 436717007188 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 436717007189 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 436717007190 dimerization interface [polypeptide binding]; other site 436717007191 LysE type translocator; Region: LysE; cl00565 436717007192 Cation efflux family; Region: Cation_efflux; cl00316 436717007193 Cd(II)/Pb(II)-responsive transcriptional regulator; Region: CadR-PbrR; TIGR02047 436717007194 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 436717007195 DNA binding residues [nucleotide binding] 436717007196 Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988 436717007197 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 436717007198 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 436717007199 Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988 436717007200 Aminopeptidase P, N-terminal domain; Region: AMP_N; pfam05195 436717007201 proline aminopeptidase P II; Provisional; Region: PRK10879 436717007202 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action...; Region: Prolidase; cd01087 436717007203 active site 436717007204 Uncharacterised protein family (UPF0149); Region: UPF0149; cl01173 436717007205 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 436717007206 Cell division protein ZapA; Region: ZapA; cl01146 436717007207 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 436717007208 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; cl00360 436717007209 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 436717007210 Found in ATP-dependent protease La (LON); Region: LON; cl01056 436717007211 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 436717007212 Walker A motif; other site 436717007213 ATP binding site [chemical binding]; other site 436717007214 Walker B motif; other site 436717007215 arginine finger; other site 436717007216 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 436717007217 Predicted SPOUT methyltransferase; Region: SPOUT_MTase; cl00679 436717007218 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 436717007219 The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363 436717007220 putative active site [active] 436717007221 metal binding site [ion binding]; metal-binding site 436717007222 META domain; Region: META; cl01245 436717007223 META domain; Region: META; cl01245 436717007224 glutamate dehydrogenase; Provisional; Region: PRK09414 436717007225 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 436717007226 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 436717007227 NAD(P) binding site [chemical binding]; other site 436717007228 electron transport complex protein RnfB; Provisional; Region: PRK05113 436717007229 Putative Fe-S cluster; Region: FeS; pfam04060 436717007230 4Fe-4S binding domain; Region: Fer4; cl02805 436717007231 endonuclease III; Provisional; Region: PRK10702 436717007232 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 436717007233 minor groove reading motif; other site 436717007234 helix-hairpin-helix signature motif; other site 436717007235 substrate binding pocket [chemical binding]; other site 436717007236 active site 436717007237 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 436717007238 adenylate kinase; Reviewed; Region: adk; PRK00279 436717007239 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 436717007240 AMP-binding site [chemical binding]; other site 436717007241 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 436717007242 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399 436717007243 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 436717007244 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 436717007245 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01039 436717007246 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 436717007247 S-adenosylmethionine binding site [chemical binding]; other site 436717007248 HupE / UreJ protein; Region: HupE_UreJ; cl01011 436717007249 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 436717007250 Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830 436717007251 UreF; Region: UreF; pfam01730 436717007252 urease accessory protein UreE; Provisional; Region: ureE; PRK13261 436717007253 UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The C-...; Region: UreE; cd00571 436717007254 dimer interface [polypeptide binding]; other site 436717007255 catalytic residues [active] 436717007256 urease subunit alpha; Reviewed; Region: ureC; PRK13207 436717007257 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 436717007258 subunit interactions [polypeptide binding]; other site 436717007259 active site 436717007260 flap region; other site 436717007261 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_beta; cd00407 436717007262 gamma-beta subunit interface [polypeptide binding]; other site 436717007263 alpha-beta subunit interface [polypeptide binding]; other site 436717007264 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 436717007265 alpha-gamma subunit interface [polypeptide binding]; other site 436717007266 beta-gamma subunit interface [polypeptide binding]; other site 436717007267 UreD urease accessory protein; Region: UreD; cl00530 436717007268 Uncharacterized lipoprotein NlpE involved in copper resistance; Region: NlpE; cl01138 436717007269 isocitrate lyase; Provisional; Region: PRK06498 436717007270 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 436717007271 tetramer interface [polypeptide binding]; other site 436717007272 active site 436717007273 Mg2+/Mn2+ binding site [ion binding]; other site 436717007274 Members of the ICL/PEPM_KPHMT enzyme superfamily catalyze the formation and cleavage of either P-C or C-C bonds. Typical members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate...; Region: ICL_KPHMT; cl00435 436717007275 Transcriptional regulator [Transcription]; Region: LysR; COG0583 436717007276 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 436717007277 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 436717007278 substrate binding pocket [chemical binding]; other site 436717007279 dimerization interface [polypeptide binding]; other site 436717007280 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 436717007281 Domain of unknown function DUF21; Region: DUF21; pfam01595 436717007282 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 436717007283 Transporter associated domain; Region: CorC_HlyC; pfam03471 436717007284 Citrate transporter; Region: CitMHS; pfam03600 436717007285 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110 436717007286 transmembrane helices; other site 436717007287 Uncharacterized protein conserved in bacteria (DUF2239); Region: DUF2239; cl01461 436717007288 sulfate adenylyltransferase subunit 1; Provisional; Region: cysN; PRK05124 436717007289 CysN_ATPS subfamily. CysN, together with protein CysD, form the ATP sulfurylase (ATPS) complex in some bacteria and lower eukaryotes. ATPS catalyzes the production of ATP sulfurylase (APS) and pyrophosphate (PPi) from ATP and sulfate. CysD, which...; Region: CysN_ATPS; cd04166 436717007290 CysD dimerization site [polypeptide binding]; other site 436717007291 G1 box; other site 436717007292 putative GEF interaction site [polypeptide binding]; other site 436717007293 GTP/Mg2+ binding site [chemical binding]; other site 436717007294 Switch I region; other site 436717007295 G2 box; other site 436717007296 G3 box; other site 436717007297 Switch II region; other site 436717007298 G4 box; other site 436717007299 G5 box; other site 436717007300 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of...; Region: CysN_NodQ_II; cd03695 436717007301 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of...; Region: CysN_NoDQ_III; cd04095 436717007302 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 436717007303 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 436717007304 Active Sites [active] 436717007305 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 436717007306 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-...; Region: LysRS_N; cd04322 436717007307 dimer interface [polypeptide binding]; other site 436717007308 putative anticodon binding site; other site 436717007309 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 436717007310 motif 1; other site 436717007311 active site 436717007312 motif 2; other site 436717007313 motif 3; other site 436717007314 Uncharacterised protein family (UPF0227); Region: UPF0227; cl14886 436717007315 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 436717007316 Rubredoxin [Energy production and conversion]; Region: COG1773 436717007317 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They...; Region: rubredoxin; cd00730 436717007318 iron binding site [ion binding]; other site 436717007319 NADH:flavorubredoxin oxidoreductase; Provisional; Region: PRK04965 436717007320 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 436717007321 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 436717007322 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 436717007323 DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151 436717007324 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 436717007325 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 436717007326 dimerization interface [polypeptide binding]; other site 436717007327 polyphosphate kinase; Provisional; Region: PRK05443 436717007328 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 436717007329 putative active site [active] 436717007330 catalytic site [active] 436717007331 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 436717007332 putative active site [active] 436717007333 putative domain interface [polypeptide binding]; other site 436717007334 catalytic site [active] 436717007335 Transglycosylase; Region: Transgly; cl07896 436717007336 Rhomboid family; Region: Rhomboid; cl11446 436717007337 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127 436717007338 FtsX-like permease family; Region: FtsX; pfam02687 436717007339 FtsX-like permease family; Region: FtsX; pfam02687 436717007340 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG4181 436717007341 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 436717007342 Walker A/P-loop; other site 436717007343 ATP binding site [chemical binding]; other site 436717007344 Q-loop/lid; other site 436717007345 ABC transporter signature motif; other site 436717007346 Walker B; other site 436717007347 D-loop; other site 436717007348 H-loop/switch region; other site 436717007349 Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822 436717007350 active site 436717007351 catalytic triad [active] 436717007352 oxyanion hole [active] 436717007353 switch loop; other site 436717007354 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378 436717007355 active site clefts [active] 436717007356 zinc binding site [ion binding]; other site 436717007357 dimer interface [polypeptide binding]; other site 436717007358 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 436717007359 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 436717007360 outer membrane receptor FepA; Provisional; Region: PRK13524 436717007361 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 436717007362 N-terminal plug; other site 436717007363 ligand-binding site [chemical binding]; other site 436717007364 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 436717007365 IscR-regulated protein YhgI; Region: YhgI_GntY; TIGR03341 436717007366 NifU-like domain; Region: NifU; cl00484 436717007367 Rhomboid family; Region: Rhomboid; cl11446 436717007368 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 436717007369 Sulfatase; Region: Sulfatase; cl10460 436717007370 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; cl00556 436717007371 D-Serine dehydratase is a pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of L- or D-serine to pyruvate and ammonia. D-serine dehydratase serves as a detoxifying enzyme in most E. coli strains where D-serine is a competitive...; Region: D-Ser-dehyd; cd06447 436717007372 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 436717007373 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 436717007374 catalytic residue [active] 436717007375 Phosphate transporter family; Region: PHO4; cl00396 436717007376 Phosphate transporter family; Region: PHO4; cl00396 436717007377 B12-dependent methionine synthase; Provisional; Region: metH; PRK09490 436717007378 Homocysteine/selenocysteine methylase (S-methylmethionine-dependent) [Amino acid transport and metabolism]; Region: MHT1; cl14105 436717007379 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 436717007380 substrate binding pocket [chemical binding]; other site 436717007381 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 436717007382 B12 binding site [chemical binding]; other site 436717007383 cobalt ligand [ion binding]; other site 436717007384 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 436717007385 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+...; Region: SIR2; cl00195 436717007386 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 436717007387 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 436717007388 PYR/PP interface [polypeptide binding]; other site 436717007389 dimer interface [polypeptide binding]; other site 436717007390 TPP binding site [chemical binding]; other site 436717007391 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 436717007392 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 436717007393 TPP-binding site [chemical binding]; other site 436717007394 dimer interface [polypeptide binding]; other site 436717007395 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 436717007396 D-galactonate transporter; Region: 2A0114; TIGR00893 436717007397 putative substrate translocation pore; other site 436717007398 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 436717007399 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 436717007400 NAD(P) binding site [chemical binding]; other site 436717007401 active site 436717007402 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 436717007403 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 436717007404 HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 436717007405 dimerization interface [polypeptide binding]; other site 436717007406 substrate binding pocket [chemical binding]; other site 436717007407 Galactose mutarotase and related enzymes [Carbohydrate transport and metabolism]; Region: GalM; COG2017 436717007408 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 436717007409 active site 436717007410 catalytic residues [active] 436717007411 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 436717007412 putative substrate translocation pore; other site 436717007413 Major Facilitator Superfamily; Region: MFS_1; pfam07690 436717007414 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 436717007415 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 436717007416 Glutaminase; Region: Glutaminase; cl00907 436717007417 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(...; Region: Pep_deformylase; cd00487 436717007418 active site 436717007419 catalytic residues [active] 436717007420 metal binding site [ion binding]; metal-binding site 436717007421 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 436717007422 metabolite-proton symporter; Region: 2A0106; TIGR00883 436717007423 putative substrate translocation pore; other site 436717007424 hypothetical protein; Provisional; Region: PRK07064 436717007425 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 436717007426 PYR/PP interface [polypeptide binding]; other site 436717007427 dimer interface [polypeptide binding]; other site 436717007428 TPP binding site [chemical binding]; other site 436717007429 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 436717007430 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin...; Region: TPP_enzymes; cd00568 436717007431 TPP-binding site [chemical binding]; other site 436717007432 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 436717007433 Uncharacterized Candidatus pelagibacter aldehyde dehydrogenase, DhaS-like; Region: ALDH_DhaS; cd07114 436717007434 NAD(P) binding site [chemical binding]; other site 436717007435 catalytic residues [active] 436717007436 L-aspartate dehydrogenase; Provisional; Region: PRK13303 436717007437 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 436717007438 Domain of unknown function DUF108; Region: DUF108; pfam01958 436717007439 short chain dehydrogenase; Provisional; Region: PRK07062 436717007440 putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344 436717007441 putative NAD(P) binding site [chemical binding]; other site 436717007442 putative active site [active] 436717007443 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 436717007444 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 436717007445 Cupin domain; Region: Cupin_2; cl09118 436717007446 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 436717007447 D-galactonate transporter; Region: 2A0114; TIGR00893 436717007448 putative substrate translocation pore; other site 436717007449 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 436717007450 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 436717007451 2,3-dihydroxybiphenyl 1,2-dioxygenase; Region: 23dbph12diox; TIGR03213 436717007452 C-terminal domain of Burkholderia sp. NF100 MhqB and similar proteins; MhqB is a type I extradiol dioxygenase involved in the catabolism of methylhydroquinone, an intermediate in the degradation of fenitrothion; Region: MhqB_like_C; cd08360 436717007453 putative active site [active] 436717007454 putative metal binding site [ion binding]; other site 436717007455 short chain dehydrogenase; Provisional; Region: PRK12939 436717007456 classical (c) SDRs; Region: SDR_c; cd05233 436717007457 NAD(P) binding site [chemical binding]; other site 436717007458 active site 436717007459 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 436717007460 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 436717007461 [2Fe-2S] cluster binding site [ion binding]; other site 436717007462 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 436717007463 hydrophobic ligand binding site; other site 436717007464 Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise...; Region: Rieske_RO_ferredoxin; cd03528 436717007465 [2Fe-2S] cluster binding site [ion binding]; other site 436717007466 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 436717007467 Transcriptional regulator [Transcription]; Region: IclR; COG1414 436717007468 Bacterial transcriptional regulator; Region: IclR; pfam01614 436717007469 Nicotinamide mononucleotide transporter; Region: NMN_transporter; cl01256 436717007470 EamA-like transporter family; Region: EamA; cl01037 436717007471 putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272 436717007472 enoyl-CoA hydratase; Provisional; Region: PRK06563 436717007473 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 436717007474 substrate binding site [chemical binding]; other site 436717007475 oxyanion hole (OAH) forming residues; other site 436717007476 trimer interface [polypeptide binding]; other site 436717007477 Predicted alpha/beta hydrolase [General function prediction only]; Region: COG4757 436717007478 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 436717007479 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 436717007480 hemin storage system protein; Provisional; Region: hmsS; cl14676 436717007481 N-glycosyltransferase; Provisional; Region: PRK11204 436717007482 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 436717007483 DXD motif; other site 436717007484 poly-beta-1,6-N-acetyl-D-glucosamine N-deacetylase PgaB; Region: deacetyl_PgaB; TIGR03938 436717007485 Polysaccharide deacetylase; Region: Polysacc_deac_1; cl12061 436717007486 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587 436717007487 YaeQ protein; Region: YaeQ; cl01913 436717007488 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 436717007489 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 436717007490 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 436717007491 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain...; Region: BFIT_BACH; cd03442 436717007492 MarC family integral membrane protein; Region: MarC; cl00919 436717007493 choline transport protein BetT; Provisional; Region: PRK09928 436717007494 BCCT family transporter; Region: BCCT; cl00569 436717007495 BCCT family transporter; Region: BCCT; cl00569 436717007496 transcriptional regulator BetI; Validated; Region: PRK00767 436717007497 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 436717007498 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 436717007499 NAD+-dependent 4-trimethylaminobutyraldehyde dehydrogenase, ALDH family 9A1; Region: ALDH_F9_TMBADH; cd07090 436717007500 tetrameric interface [polypeptide binding]; other site 436717007501 NAD binding site [chemical binding]; other site 436717007502 catalytic residues [active] 436717007503 choline dehydrogenase; Validated; Region: PRK02106 436717007504 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 436717007505 Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl14881 436717007506 Predicted dehydrogenase [General function prediction only]; Region: COG0579 436717007507 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 436717007508 Homocysteine/selenocysteine methylase (S-methylmethionine-dependent) [Amino acid transport and metabolism]; Region: MHT1; cl14105 436717007509 Transmembrane amino acid transporter protein; Region: Aa_trans; cl00524 436717007510 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 436717007511 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 436717007512 Protein of unknown function (DUF1275); Region: DUF1275; cl01453 436717007513 Protein of unknown function (DUF454); Region: DUF454; cl01063 436717007514 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cd00232 436717007515 heme binding pocket [chemical binding]; other site 436717007516 heme ligand [chemical binding]; other site 436717007517 Gram-negative bacterial tonB protein; Region: TonB; cl10048 436717007518 Protein of unknown function (DUF560); Region: DUF560; pfam04575 436717007519 Secretin and TonB N terminus short domain; Region: STN; pfam07660 436717007520 TonB-dependent Receptor Plug Domain; Region: Plug; cl08461 436717007521 TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786 436717007522 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16...; Region: OM_channels; cl00284 436717007523 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 436717007524 FecR protein; Region: FecR; pfam04773 436717007525 RNA polymerase sigma factor; Reviewed; Region: PRK12523 436717007526 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 436717007527 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cl01055 436717007528 Transcriptional regulator [Transcription]; Region: LysR; COG0583 436717007529 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 436717007530 The C-teminal substrate binding domain of LysR-like nitrogen assimilation control (NAC) protein, contains the type 2 periplasmic binding fold; Region: PBP2_Nac; cd08433 436717007531 putative dimerization interface [polypeptide binding]; other site 436717007532 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 436717007533 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 436717007534 inhibitor site; inhibition site 436717007535 active site 436717007536 dimer interface [polypeptide binding]; other site 436717007537 catalytic residue [active] 436717007538 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 436717007539 benzoate transport; Region: 2A0115; TIGR00895 436717007540 putative substrate translocation pore; other site 436717007541 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 436717007542 outer membrane porin, OprD family; Region: OprD; pfam03573 436717007543 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins...; Region: HNHc; cl00083 436717007544 Domain of unknown function DUF87; Region: DUF87; pfam01935 436717007545 HerA helicase [Replication, recombination, and repair]; Region: COG0433 436717007546 D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; cl00408 436717007547 Uncharacterised ACR, COG2135; Region: DUF159; cl03646 436717007548 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (...; Region: S24_LexA-like; cd06529 436717007549 Catalytic site [active] 436717007550 DNA polymerase V subunit UmuC; Reviewed; Region: umuC; PRK03609 436717007551 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 436717007552 active site 436717007553 DNA binding site [nucleotide binding] 436717007554 Predicted lysozyme (DUF847); Region: DUF847; pfam05838 436717007555 Predicted Peptidoglycan domain; Region: PG_binding_3; pfam09374 436717007556 Lysis protein S; Region: Lysis_S; pfam04971 436717007557 Phage-related protein, tail component [Function unknown]; Region: COG4733 436717007558 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cl00065 436717007559 NlpC/P60 family; Region: NLPC_P60; cl11438 436717007560 Uncharacterized conserved protein (DUF2163); Region: DUF2163; pfam09931 436717007561 Phage conserved hypothetical protein BR0599; Region: Phage_BR0599; pfam09356 436717007562 Conserved hypothetical protein 2217 (DUF2460); Region: DUF2460; cl02268 436717007563 putative protein serine/threonine phosphatase; Provisional; Region: PRK14559 436717007564 1-deoxy-D-xylulose 5-phosphate reductoisomerase [Lipid metabolism]; Region: Dxr; COG0743 436717007565 Encapsulating protein for peroxidase; Region: Linocin_M18; cl12047 436717007566 Uncharacterized protein conserved in bacteria (DUF2184); Region: DUF2184; pfam09950 436717007567 Uncharacterized protein conserved in bacteria (DUF2213); Region: DUF2213; pfam09979 436717007568 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3566 436717007569 Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072 436717007570 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3567; cl12082 436717007571 Protein of unknown function (DUF1073); Region: DUF1073; pfam06381 436717007572 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5410 436717007573 Terminase-like family; Region: Terminase_6; pfam03237 436717007574 Phage-related terminase [General function prediction only]; Region: COG5362; cl02216 436717007575 Uncharacterized conserved protein (DUF2280); Region: DUF2280; cl02353 436717007576 D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; cl00408 436717007577 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 436717007578 putative active site [active] 436717007579 Pyocin large subunit [General function prediction only]; Region: COG5529 436717007580 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 436717007581 cofactor binding site; other site 436717007582 DNA binding site [nucleotide binding] 436717007583 substrate interaction site [chemical binding]; other site 436717007584 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 436717007585 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl09100 436717007586 Predicted transcriptional regulator [Transcription]; Region: COG2932 436717007587 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (...; Region: S24_LexA-like; cd06529 436717007588 Catalytic site [active] 436717007589 phage nucleotide-binding protein; Region: phage_P_loop; TIGR01618 436717007590 Ftsk gamma domain; Region: Ftsk_gamma; cl09645 436717007591 bifunctional UDP-glucuronic acid decarboxylase/UDP-4-amino-4-deoxy-L-arabinose formyltransferase; Validated; Region: PRK08125 436717007592 integrase; Provisional; Region: PRK09692 436717007593 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 436717007594 active site 436717007595 Int/Topo IB signature motif; other site 436717007596 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040 436717007597 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 436717007598 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 436717007599 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 436717007600 putative substrate translocation pore; other site 436717007601 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 436717007602 efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998 436717007603 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 436717007604 CoenzymeA binding site [chemical binding]; other site 436717007605 subunit interaction site [polypeptide binding]; other site 436717007606 PHB binding site; other site 436717007607 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823 436717007608 dimer interface [polypeptide binding]; other site 436717007609 allosteric magnesium binding site [ion binding]; other site 436717007610 active site 436717007611 aspartate-rich active site metal binding site; other site 436717007612 Schiff base residues; other site 436717007613 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 436717007614 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 436717007615 Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl14881 436717007616 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 436717007617 TIGR01777 family protein; Region: yfcH 436717007618 NAD(P) binding site [chemical binding]; other site 436717007619 active site 436717007620 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 436717007621 OsmC-like protein; Region: OsmC; cl00767 436717007622 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 436717007623 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 436717007624 active site 436717007625 metal binding site [ion binding]; metal-binding site 436717007626 DNA binding site [nucleotide binding] 436717007627 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 436717007628 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 436717007629 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 436717007630 Walker A/P-loop; other site 436717007631 ATP binding site [chemical binding]; other site 436717007632 Q-loop/lid; other site 436717007633 exonuclease subunit SbcC; Provisional; Region: PRK10246 436717007634 SbcCD and other Mre11/Rad50 (MR) complexes are implicated in the metabolism of DNA ends. They cleave ends sealed by hairpin structures and are thought to play a role in removing protein bound to DNA termini; Region: ABC_sbcCD; cd03279 436717007635 ABC transporter signature motif; other site 436717007636 Walker B; other site 436717007637 D-loop; other site 436717007638 H-loop/switch region; other site 436717007639 Bacitracin resistance protein BacA; Region: BacA; cl00858 436717007640 Pyridoxal 5-phosphate (PLP)-binding TIM barrel domain of Type III PLP-Dependent Enzymes, Yggs-like proteins; Region: PLPDE_III_Yggs_like; cd06824 436717007641 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 436717007642 catalytic residue [active] 436717007643 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 436717007644 Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131 436717007645 Walker A motif; other site 436717007646 ATP binding site [chemical binding]; other site 436717007647 Walker B motif; other site 436717007648 Tfp pilus assembly protein, ATPase PilU [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilU; COG5008 436717007649 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 436717007650 Walker A motif; other site 436717007651 ATP binding site [chemical binding]; other site 436717007652 Walker B motif; other site 436717007653 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 436717007654 metal binding site 2 [ion binding]; metal-binding site 436717007655 putative DNA binding helix; other site 436717007656 metal binding site 1 [ion binding]; metal-binding site 436717007657 dimer interface [polypeptide binding]; other site 436717007658 structural Zn2+ binding site [ion binding]; other site 436717007659 SmpA / OmlA family; Region: SmpA_OmlA; cl01095 436717007660 Uncharacterised protein family (UPF0125); Region: UPF0125; cl01096 436717007661 hypothetical protein; Provisional; Region: PRK00808 436717007662 Hemerythrin (Hr) is a non-heme diiron oxygen transport protein found in four marine invertebrate phyla including priapulida, brachiopoda, sipunculida, and annelida, as well as in protozoa. Myohemerythrin (Mhr), a hemerythrin homolog, is found in the...; Region: Hemerythrin; cl11605 436717007663 octamerization interface [polypeptide binding]; other site 436717007664 diferric-oxygen binding site [ion binding]; other site 436717007665 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 436717007666 putative active site [active] 436717007667 putative dimer interface [polypeptide binding]; other site 436717007668 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 436717007669 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using...; Region: AAK_NAGK-C; cd04250 436717007670 feedback inhibition sensing region; other site 436717007671 homohexameric interface [polypeptide binding]; other site 436717007672 nucleotide binding site [chemical binding]; other site 436717007673 N-acetyl-L-glutamate binding site [chemical binding]; other site 436717007674 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 436717007675 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 436717007676 active site 436717007677 substrate binding site [chemical binding]; other site 436717007678 metal binding site [ion binding]; metal-binding site 436717007679 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 436717007680 trimer interface [polypeptide binding]; other site 436717007681 active site 436717007682 ATP-dependent DNA helicase Rep; Region: rep; TIGR01074 436717007683 UvrD/REP helicase; Region: UvrD-helicase; cl14126 436717007684 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 436717007685 ligand binding site [chemical binding]; other site 436717007686 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; Region: LPLAT_LCLAT1-like; cd07990 436717007687 putative acyl-acceptor binding pocket; other site 436717007688 Septum formation inhibitor [Cell division and chromosome partitioning]; Region: MinC; COG0850 436717007689 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 436717007690 Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894 436717007691 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a...; Region: MinD; cd02036 436717007692 Switch I; other site 436717007693 Switch II; other site 436717007694 Septum formation topological specificity factor MinE; Region: MinE; cl00538 436717007695 LysE type translocator; Region: LysE; cl00565 436717007696 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 436717007697 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 436717007698 Ftsk gamma domain; Region: Ftsk_gamma; cl09645 436717007699 thioredoxin reductase; Provisional; Region: PRK10262 436717007700 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 436717007701 Leucyl/phenylalanyl-tRNA protein transferase; Region: Leu_Phe_trans; cl01006 436717007702 arginyl-tRNA-protein transferase; Provisional; Region: PRK01305 436717007703 Arginine-tRNA-protein transferase, N terminus; Region: ATE_N; pfam04376 436717007704 Arginine-tRNA-protein transferase, C terminus; Region: ATE_C; pfam04377 436717007705 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 436717007706 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 436717007707 Coenzyme A binding pocket [chemical binding]; other site 436717007708 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687 436717007709 Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118 436717007710 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687 436717007711 Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118 436717007712 elongation factor Tu; Reviewed; Region: PRK00049 436717007713 EF-Tu subfamily. This subfamily includes orthologs of translation elongation factor EF-Tu in bacteria, mitochondria, and chloroplasts. It is one of several GTP-binding translation factors found in the larger family of GTP-binding elongation factors; Region: EF_Tu; cd01884 436717007714 G1 box; other site 436717007715 GEF interaction site [polypeptide binding]; other site 436717007716 GTP/Mg2+ binding site [chemical binding]; other site 436717007717 Switch I region; other site 436717007718 G2 box; other site 436717007719 G3 box; other site 436717007720 Switch II region; other site 436717007721 G4 box; other site 436717007722 G5 box; other site 436717007723 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 436717007724 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts)...; Region: EFTU_III; cd03707 436717007725 Antibiotic Binding Site [chemical binding]; other site 436717007726 elongation factor G; Reviewed; Region: PRK00007 436717007727 Elongation factor G (EF-G) subfamily. Translocation is mediated by EF-G (also called translocase). The structure of EF-G closely resembles that of the complex between EF-Tu and tRNA. This is an example of molecular mimicry; a protein domain evolved...; Region: EF-G; cd01886 436717007728 G1 box; other site 436717007729 putative GEF interaction site [polypeptide binding]; other site 436717007730 GTP/Mg2+ binding site [chemical binding]; other site 436717007731 Switch I region; other site 436717007732 G2 box; other site 436717007733 G3 box; other site 436717007734 Switch II region; other site 436717007735 G4 box; other site 436717007736 G5 box; other site 436717007737 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide...; Region: EFG_mtEFG_II; cd04088 436717007738 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor...; Region: EFG_mtEFG1_IV; cd01434 436717007739 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor...; Region: EFG_mtEFG_C; cd03713 436717007740 Ribosomal protein S7p/S5e; Region: Ribosomal_S7; cl00313 436717007741 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 436717007742 S17 interaction site [polypeptide binding]; other site 436717007743 S8 interaction site; other site 436717007744 16S rRNA interaction site [nucleotide binding]; other site 436717007745 streptomycin interaction site [chemical binding]; other site 436717007746 23S rRNA interaction site [nucleotide binding]; other site 436717007747 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 436717007748 EcsC protein family; Region: EcsC; pfam12787 436717007749 3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK07967 436717007750 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 436717007751 dimer interface [polypeptide binding]; other site 436717007752 active site 436717007753 Uncharacterised protein family (UPF0093); Region: UPF0093; cl00863 436717007754 NAD synthetase; Provisional; Region: PRK13981 436717007755 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 436717007756 multimer interface [polypeptide binding]; other site 436717007757 active site 436717007758 catalytic triad [active] 436717007759 protein interface 1 [polypeptide binding]; other site 436717007760 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to...; Region: NAD_synthase; cd00553 436717007761 homodimer interface [polypeptide binding]; other site 436717007762 NAD binding pocket [chemical binding]; other site 436717007763 ATP binding pocket [chemical binding]; other site 436717007764 Mg binding site [ion binding]; other site 436717007765 active-site loop [active] 436717007766 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 436717007767 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-...; Region: PDR_like; cd06185 436717007768 FMN-binding pocket [chemical binding]; other site 436717007769 flavin binding motif; other site 436717007770 phosphate binding motif [ion binding]; other site 436717007771 beta-alpha-beta structure motif; other site 436717007772 NAD binding pocket [chemical binding]; other site 436717007773 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 436717007774 catalytic loop [active] 436717007775 iron binding site [ion binding]; other site 436717007776 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 436717007777 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 436717007778 tetramerization interface [polypeptide binding]; other site 436717007779 NAD(P) binding site [chemical binding]; other site 436717007780 catalytic residues [active] 436717007781 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 436717007782 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 436717007783 [2Fe-2S] cluster binding site [ion binding]; other site 436717007784 C-terminal catalytic domain of the oxygenase alpha subunit of an uncharacterized subgroup of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C_2; cd08886 436717007785 putative alpha subunit interface [polypeptide binding]; other site 436717007786 putative active site [active] 436717007787 putative substrate binding site [chemical binding]; other site 436717007788 Fe binding site [ion binding]; other site 436717007789 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 436717007790 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 436717007791 substrate binding pocket [chemical binding]; other site 436717007792 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 436717007793 BCCT family transporter; Region: BCCT; cl00569 436717007794 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 436717007795 transcriptional activator TtdR; Provisional; Region: PRK09801 436717007796 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 436717007797 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_9; cd08479 436717007798 putative effector binding pocket; other site 436717007799 putative dimerization interface [polypeptide binding]; other site 436717007800 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 436717007801 active site 436717007802 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 436717007803 SmpB-tmRNA interface; other site 436717007804 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 436717007805 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; cl00650 436717007806 23S rRNA pseudouridine synthase D; Provisional; Region: rluD; PRK11180 436717007807 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 436717007808 RNA binding surface [nucleotide binding]; other site 436717007809 PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF...; Region: PseudoU_synth_RluCD_like; cd02869 436717007810 active site 436717007811 outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302 436717007812 DNA primase, catalytic core; Region: dnaG; TIGR01391 436717007813 CHC2 zinc finger; Region: zf-CHC2; cl02597 436717007814 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 436717007815 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 436717007816 active site 436717007817 metal binding site [ion binding]; metal-binding site 436717007818 interdomain interaction site; other site 436717007819 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 436717007820 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 436717007821 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 436717007822 tRNA; other site 436717007823 putative tRNA binding site [nucleotide binding]; other site 436717007824 putative NADP binding site [chemical binding]; other site 436717007825 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 436717007826 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 436717007827 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cl02429 436717007828 binding surface 436717007829 TPR motif; other site 436717007830 outer membrane lipoprotein LolB; Provisional; Region: lolB; PRK00022 436717007831 Outer membrane lipoprotein LolB; Region: LolB; pfam03550 436717007832 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00343 436717007833 GHMP kinases N terminal domain; Region: GHMP_kinases_N; cl08256 436717007834 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 436717007835 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK04923 436717007836 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 436717007837 Ribosomal_L25_TL5_CTC: Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain. L25 is a single-domain protein, homologous to the N-terminal domain of TL5 and CTC, which each contain two domains. CTC is a known stress protein, and proteins of this...; Region: Ribosomal_L25_TL5_CTC; cd00495 436717007838 5S rRNA interface [nucleotide binding]; other site 436717007839 CTC domain interface; other site 436717007840 L16 interface [polypeptide binding]; other site 436717007841 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 436717007842 putative active site [active] 436717007843 catalytic residue [active] 436717007844 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 436717007845 tetramerization interface [polypeptide binding]; other site 436717007846 active site 436717007847 Uncharacterized membrane-anchored protein [Function unknown]; Region: COG4929 436717007848 Predicted membrane protein (DUF2157); Region: DUF2157; cl10480 436717007849 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; cl00336 436717007850 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 436717007851 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 436717007852 motif II; other site 436717007853 bifunctional hydroxy-methylpyrimidine kinase/ hydroxy-phosphomethylpyrimidine kinase; Reviewed; Region: PRK06427 436717007854 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 436717007855 dimer interface [polypeptide binding]; other site 436717007856 substrate binding site [chemical binding]; other site 436717007857 ATP binding site [chemical binding]; other site 436717007858 LysM domain/BON superfamily protein; Provisional; Region: PRK11198 436717007859 BON domain; Region: BON; cl02771 436717007860 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 436717007861 putative peptidoglycan binding site; other site 436717007862 Phosphopantetheine attachment site; Region: PP-binding; cl09936 436717007863 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 436717007864 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 436717007865 NAD(P) binding site [chemical binding]; other site 436717007866 homotetramer interface [polypeptide binding]; other site 436717007867 homodimer interface [polypeptide binding]; other site 436717007868 active site 436717007869 Acyl transferase domain; Region: Acyl_transf_1; cl08282 436717007870 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 436717007871 Ribosomal L32p protein family; Region: Ribosomal_L32p; cl09115 436717007872 Uncharacterized ACR, COG1399; Region: DUF177; cl00616 436717007873 Protein of unknown function, DUF462; Region: DUF462; cl01190 436717007874 yrdC domain; Region: Sua5_yciO_yrdC; cl00305 436717007875 ScpA/B protein; Region: ScpA_ScpB; cl00598 436717007876 Putative transcriptional regulators (Ypuh-like); Region: DUF387; cl00612 436717007877 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 436717007878 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 436717007879 RNA binding surface [nucleotide binding]; other site 436717007880 PseudoU_synth_RluB: Pseudouridine synthase, Escherichia coli RluB like. This group is comprised of bacterial and eukaryotic proteins similar to E. coli RluB. Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to...; Region: PseudoU_synth_RluB; cd02556 436717007881 probable active site [active] 436717007882 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 436717007883 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 436717007884 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 436717007885 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 436717007886 S-adenosylmethionine binding site [chemical binding]; other site 436717007887 7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156 436717007888 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 436717007889 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 436717007890 catalytic residue [active] 436717007891 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase...; Region: OAT_like; cd00610 436717007892 adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK06173 436717007893 inhibitor-cofactor binding pocket; inhibition site 436717007894 pyridoxal 5'-phosphate binding site [chemical binding]; other site 436717007895 catalytic residue [active] 436717007896 putative pimeloyl-BioC--CoA transferase BioH; Region: bioH; TIGR01738 436717007897 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 436717007898 Trehalose-phosphatase; Region: Trehalose_PPase; pfam02358 436717007899 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is...; Region: GT1_TPS; cd03788 436717007900 alpha,alpha-trehalose-phosphate synthase [UDP-forming]; Region: trehalose_OtsA; TIGR02400 436717007901 active site 436717007902 homotetramer interface [polypeptide binding]; other site 436717007903 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 436717007904 putative substrate translocation pore; other site 436717007905 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 436717007906 Ferritin-like domain; Region: Ferritin; pfam00210 436717007907 heme binding site [chemical binding]; other site 436717007908 ferroxidase pore; other site 436717007909 ferroxidase diiron center [ion binding]; other site 436717007910 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 436717007911 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 436717007912 nucleotide binding pocket [chemical binding]; other site 436717007913 K-X-D-G motif; other site 436717007914 catalytic site [active] 436717007915 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 436717007916 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 436717007917 Helix-hairpin-helix motif; Region: HHH_2; pfam12826 436717007918 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo/...; Region: BRCT; cd00027 436717007919 Dimer interface [polypeptide binding]; other site 436717007920 BRCT sequence motif; other site 436717007921 ZipA C-terminal domain. ZipA, a membrane-anchored protein, is one of at least nine essential gene products necessary for assembly of the septal ring which mediates cell division in E.coli. ZipA and FtsA directly bind FtsZ, a homolog of eukaryotic...; Region: ZipA; cl12038 436717007922 FtsZ protein binding site [polypeptide binding]; other site 436717007923 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 436717007924 Barmotin is a tight junction-associated protein expressed in rat epithelial cells which is thought to have an important regulatory role in tight junction barrier function. Barmotin belongs to the SMC protein family. SMC proteins are large (...; Region: ABC_SMC_barmotin; cd03278 436717007925 Walker A/P-loop; other site 436717007926 ATP binding site [chemical binding]; other site 436717007927 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 436717007928 Barmotin is a tight junction-associated protein expressed in rat epithelial cells which is thought to have an important regulatory role in tight junction barrier function. Barmotin belongs to the SMC protein family. SMC proteins are large (...; Region: ABC_SMC_barmotin; cd03278 436717007929 ABC transporter signature motif; other site 436717007930 Walker B; other site 436717007931 D-loop; other site 436717007932 H-loop/switch region; other site 436717007933 Transcriptional regulators [Transcription]; Region: GntR; COG1802 436717007934 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 436717007935 DNA-binding site [nucleotide binding]; DNA binding site 436717007936 Predicted permeases [General function prediction only]; Region: COG0730; cl00498 436717007937 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 436717007938 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 436717007939 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 436717007940 Bordetella pertussis Bvg accessory factor family; Region: Bvg_acc_factor; cl09130 436717007941 signal recognition particle protein; Provisional; Region: PRK10867 436717007942 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 436717007943 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 436717007944 GTP binding site [chemical binding]; other site 436717007945 Signal peptide binding domain; Region: SRP_SPB; pfam02978 436717007946 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 436717007947 tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042 436717007948 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and...; Region: DUS_like_FMN; cd02801 436717007949 FMN binding site [chemical binding]; other site 436717007950 active site 436717007951 catalytic residues [active] 436717007952 substrate binding site [chemical binding]; other site 436717007953 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 436717007954 trimer interface [polypeptide binding]; other site 436717007955 active site 436717007956 LysE type translocator; Region: LysE; cl00565 436717007957 Uncharacterized protein conserved in bacteria (DUF2062); Region: DUF2062; cl01261 436717007958 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 436717007959 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 436717007960 methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133 436717007961 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 436717007962 active site 436717007963 HIGH motif; other site 436717007964 KMSKS motif; other site 436717007965 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 436717007966 tRNA binding surface [nucleotide binding]; other site 436717007967 anticodon binding site; other site 436717007968 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 436717007969 dimer interface [polypeptide binding]; other site 436717007970 putative tRNA-binding site [nucleotide binding]; other site 436717007971 LysE type translocator; Region: LysE; cl00565 436717007972 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 436717007973 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 436717007974 putative substrate translocation pore; other site 436717007975 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 436717007976 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 436717007977 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD)...; Region: Trp-synth-beta_II; cl00342 436717007978 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 436717007979 catalytic residue [active] 436717007980 Predicted flavoproteins [General function prediction only]; Region: COG2081 436717007981 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 436717007982 Conserved TM helix; Region: TM_helix; pfam05552 436717007983 Conserved TM helix; Region: TM_helix; pfam05552 436717007984 Conserved TM helix; Region: TM_helix; pfam05552 436717007985 ferredoxin-NADP reductase; Provisional; Region: PRK10926 436717007986 Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195 436717007987 FAD binding pocket [chemical binding]; other site 436717007988 FAD binding motif [chemical binding]; other site 436717007989 phosphate binding motif [ion binding]; other site 436717007990 beta-alpha-beta structure motif; other site 436717007991 NAD binding pocket [chemical binding]; other site 436717007992 putative DNA-binding transcriptional regulator; Provisional; Region: PRK10837 436717007993 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 436717007994 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 436717007995 putative dimerization interface [polypeptide binding]; other site 436717007996 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein...; Region: CSP_CDS; cd04458 436717007997 DNA-binding site [nucleotide binding]; DNA binding site 436717007998 RNA-binding motif; other site 436717007999 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 436717008000 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 436717008001 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 436717008002 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 436717008003 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 436717008004 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 436717008005 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 436717008006 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492 436717008007 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 436717008008 NADH dehydrogenase subunit J; Provisional; Region: PRK06433; cl14634 436717008009 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 436717008010 4Fe-4S binding domain; Region: Fer4; cl02805 436717008011 4Fe-4S binding domain; Region: Fer4; cl02805 436717008012 NADH dehydrogenase; Region: NADHdh; cl00469 436717008013 NADH dehydrogenase subunit G; Validated; Region: PRK08166 436717008014 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 436717008015 catalytic loop [active] 436717008016 iron binding site [ion binding]; other site 436717008017 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 436717008018 MopB_NDH-1_NuoG2-N7: The second domain of the NuoG subunit (with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex in the respiratory...; Region: MopB_NDH-1_NuoG2-N7; cd02771 436717008019 [4Fe-4S] binding site [ion binding]; other site 436717008020 MopB_CT_NDH-1_NuoG2-N7: C-terminal region of the NuoG-like subunit (of the variant with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting...; Region: MopB_CT_NDH-1_NuoG2-N7; cd02788 436717008021 NADH dehydrogenase I subunit F; Provisional; Region: PRK11278 436717008022 Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512 436717008023 SLBB domain; Region: SLBB; pfam10531 436717008024 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 436717008025 NADH-quinone oxidoreductase, E subunit; Region: nuoE_fam; TIGR01958 436717008026 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of...; Region: TRX_Fd_NuoE; cd03064 436717008027 putative dimer interface [polypeptide binding]; other site 436717008028 [2Fe-2S] cluster binding site [ion binding]; other site 436717008029 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl00539 436717008030 bifunctional NADH:ubiquinone oxidoreductase subunit C/D; Provisional; Region: PRK11742 436717008031 Respiratory-chain NADH dehydrogenase, 49 Kd subunit; Region: Complex1_49kDa; cl00417 436717008032 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; cl00419 436717008033 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3; Region: Oxidored_q4; cl00535 436717008034 MASE1; Region: MASE1; pfam05231 436717008035 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 436717008036 metal binding site [ion binding]; metal-binding site 436717008037 active site 436717008038 I-site; other site 436717008039 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cd06225 436717008040 dimerization interface [polypeptide binding]; other site 436717008041 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 436717008042 dimer interface [polypeptide binding]; other site 436717008043 phosphorylation site [posttranslational modification] 436717008044 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 436717008045 ATP binding site [chemical binding]; other site 436717008046 Mg2+ binding site [ion binding]; other site 436717008047 G-X-G motif; other site 436717008048 DNA-binding transcriptional regulator RstA; Provisional; Region: PRK10701 436717008049 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 436717008050 active site 436717008051 phosphorylation site [posttranslational modification] 436717008052 intermolecular recognition site; other site 436717008053 dimerization interface [polypeptide binding]; other site 436717008054 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 436717008055 DNA binding site [nucleotide binding] 436717008056 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07207 436717008057 ATP cone domain; Region: ATP-cone; pfam03477 436717008058 Class I ribonucleotide reductase; Region: RNR_I; cd01679 436717008059 active site 436717008060 dimer interface [polypeptide binding]; other site 436717008061 catalytic residues [active] 436717008062 effector binding site; other site 436717008063 R2 peptide binding site; other site 436717008064 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 436717008065 dimer interface [polypeptide binding]; other site 436717008066 putative radical transfer pathway; other site 436717008067 diiron center [ion binding]; other site 436717008068 tyrosyl radical; other site 436717008069 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 436717008070 aspartate aminotransferase; Provisional; Region: PRK08361 436717008071 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 436717008072 pyridoxal 5'-phosphate binding site [chemical binding]; other site 436717008073 homodimer interface [polypeptide binding]; other site 436717008074 catalytic residue [active] 436717008075 hypothetical protein; Provisional; Region: PRK09897 436717008076 Cupin domain; Region: Cupin_2; cl09118 436717008077 Predicted ATPase [General function prediction only]; Region: COG1485 436717008078 chromosome replication initiation inhibitor protein; Validated; Region: PRK03635 436717008079 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 436717008080 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 436717008081 dimerization interface [polypeptide binding]; other site 436717008082 Diaminopimelate epimerase; Region: DAP_epimerase; cl14668 436717008083 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 436717008084 Transcriptional regulator [Transcription]; Region: LysR; COG0583 436717008085 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 436717008086 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 436717008087 dimerization interface [polypeptide binding]; other site 436717008088 pyrimidine utilization regulatory protein R; Region: RutR; TIGR03613 436717008089 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 436717008090 Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; cl01733 436717008091 Sel1 repeat; Region: Sel1; cl02723 436717008092 Sel1 repeat; Region: Sel1; cl02723 436717008093 Sel1 repeat; Region: Sel1; cl02723 436717008094 Sel1 repeat; Region: Sel1; cl02723 436717008095 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 436717008096 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 436717008097 Flavin Reductases; Region: FlaRed; cl00801 436717008098 methionine synthase; Provisional; Region: PRK01207 436717008099 C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme catalyses the last step in the production of methionine by...; Region: CIMS_C_terminal_like; cd03311 436717008100 substrate binding site [chemical binding]; other site 436717008101 THF binding site; other site 436717008102 zinc-binding site [ion binding]; other site 436717008103 Domain of unknown function (DUF1852); Region: DUF1852; pfam08908 436717008104 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 436717008105 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 436717008106 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 436717008107 dimerization interface [polypeptide binding]; other site 436717008108 LysE type translocator; Region: LysE; cl00565 436717008109 Fatty acid desaturase; Region: FA_desaturase; pfam00487 436717008110 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 436717008111 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 436717008112 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 436717008113 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 436717008114 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like6; cd05664 436717008115 metal binding site [ion binding]; metal-binding site 436717008116 putative dimer interface [polypeptide binding]; other site 436717008117 Long-chain fatty acid transport protein [Lipid metabolism]; Region: FadL; COG2067 436717008118 Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; cl09488 436717008119 Transcriptional regulator [Transcription]; Region: LysR; COG0583 436717008120 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 436717008121 The C-teminal substrate binding domain of LysR-like nitrogen assimilation control (NAC) protein, contains the type 2 periplasmic binding fold; Region: PBP2_Nac; cd08433 436717008122 putative dimerization interface [polypeptide binding]; other site 436717008123 citrate-proton symporter; Provisional; Region: PRK15075 436717008124 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 436717008125 putative substrate translocation pore; other site 436717008126 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 436717008127 nitrogen assimilation transcriptional regulator; Provisional; Region: PRK11233 436717008128 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 436717008129 The C-teminal substrate binding domain of LysR-like nitrogen assimilation control (NAC) protein, contains the type 2 periplasmic binding fold; Region: PBP2_Nac; cd08433 436717008130 putative dimerization interface [polypeptide binding]; other site 436717008131 tricarballylate dehydrogenase; Validated; Region: PRK08274 436717008132 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 436717008133 tricarballylate utilization protein B; Provisional; Region: PRK15033 436717008134 HPP family; Region: HPP; pfam04982 436717008135 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 436717008136 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 436717008137 CoA-transferase family III; Region: CoA_transf_3; cl00778 436717008138 benzoate transport; Region: 2A0115; TIGR00895 436717008139 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 436717008140 putative substrate translocation pore; other site 436717008141 Glutaryl-CoA dehydrogenase; Region: GCD; cd01151 436717008142 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 436717008143 FAD binding site [chemical binding]; other site 436717008144 substrate binding pocket [chemical binding]; other site 436717008145 catalytic base [active] 436717008146 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 436717008147 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 436717008148 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 436717008149 dimerization interface [polypeptide binding]; other site 436717008150 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 436717008151 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH8; cd08262 436717008152 putative NAD(P) binding site [chemical binding]; other site 436717008153 catalytic Zn binding site [ion binding]; other site 436717008154 Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320 436717008155 active site 436717008156 purine riboside binding site [chemical binding]; other site 436717008157 Quinolinate synthetase A protein; Region: NadA; cl00420 436717008158 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group...; Region: OAT; cd02152 436717008159 heterotetramer interface [polypeptide binding]; other site 436717008160 active site pocket [active] 436717008161 cleavage site 436717008162 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 436717008163 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 436717008164 DNA binding site [nucleotide binding] 436717008165 active site 436717008166 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 436717008167 Cation efflux family; Region: Cation_efflux; cl00316 436717008168 Copper resistance protein B precursor (CopB); Region: CopB; cl01476 436717008169 copper-resistance protein, CopA family; Region: copper_res_A; TIGR01480 436717008170 Multicopper oxidase; Region: Cu-oxidase; cl14658 436717008171 Multicopper oxidase; Region: Cu-oxidase; cl14658 436717008172 Multicopper oxidase; Region: Cu-oxidase; cl14658 436717008173 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 436717008174 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 436717008175 active site 436717008176 motif I; other site 436717008177 motif II; other site 436717008178 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 436717008179 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative...; Region: RPE; cd00429 436717008180 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 436717008181 substrate binding site [chemical binding]; other site 436717008182 hexamer interface [polypeptide binding]; other site 436717008183 metal binding site [ion binding]; metal-binding site 436717008184 Uncharacterized protein conserved in bacteria (DUF2218); Region: DUF2218; cl01424 436717008185 Predicted esterase [General function prediction only]; Region: COG0627 436717008186 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 436717008187 Peptidase C13 family; Region: Peptidase_C13; cl02159 436717008188 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 436717008189 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl14000 436717008190 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 436717008191 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 436717008192 trimer interface [polypeptide binding]; other site 436717008193 putative metal binding site [ion binding]; other site 436717008194 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 436717008195 putative active site [active] 436717008196 putative CoA binding site [chemical binding]; other site 436717008197 nudix motif; other site 436717008198 metal binding site [ion binding]; metal-binding site 436717008199 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_4; cd04511 436717008200 nudix motif; other site 436717008201 Long-chain fatty acid transport protein [Lipid metabolism]; Region: FadL; COG2067 436717008202 Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; cl09488 436717008203 bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase precursor protein; Reviewed; Region: PRK11907 436717008204 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the 'double-glycine' leader peptides from the precursors of various...; Region: Peptidase_C39G; cd02423 436717008205 putative active site [active] 436717008206 anthranilate synthase component I, archaeal clade; Region: TrpE-arch; TIGR01820 436717008207 chorismate binding enzyme; Region: Chorismate_bind; cl10555 436717008208 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 436717008209 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 436717008210 pyridoxal 5'-phosphate binding site [chemical binding]; other site 436717008211 homodimer interface [polypeptide binding]; other site 436717008212 catalytic residue [active] 436717008213 Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141 436717008214 E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent oxidation of L-histidinol to L-...; Region: Histidinol_dh; cd06572 436717008215 NAD binding site [chemical binding]; other site 436717008216 dimerization interface [polypeptide binding]; other site 436717008217 product binding site; other site 436717008218 substrate binding site [chemical binding]; other site 436717008219 zinc binding site [ion binding]; other site 436717008220 catalytic residues [active] 436717008221 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 436717008222 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Validated; Region: PRK09369 436717008223 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 436717008224 hinge; other site 436717008225 active site 436717008226 BolA-like protein; Region: BolA; cl00386 436717008227 RaiA ('ribosome-associated inhibitor A', also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal A site...; Region: RaiA; cd00552 436717008228 30S subunit binding site; other site 436717008229 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 436717008230 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 436717008231 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 436717008232 VacJ like lipoprotein; Region: VacJ; cl01073 436717008233 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 436717008234 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 436717008235 anti sigma factor interaction site; other site 436717008236 regulatory phosphorylation site [posttranslational modification]; other site 436717008237 Predicted amidohydrolase [General function prediction only]; Region: COG0388 436717008238 Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases); Region: nit; cd07572 436717008239 putative active site [active] 436717008240 catalytic triad [active] 436717008241 dimer interface [polypeptide binding]; other site 436717008242 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 436717008243 OsmC-like protein; Region: OsmC; cl00767 436717008244 general secretory pathway protein E; Region: type_II_gspE; TIGR02533 436717008245 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 436717008246 Walker A motif; other site 436717008247 ATP binding site [chemical binding]; other site 436717008248 Walker B motif; other site 436717008249 Mechanosensitive ion channel; Region: MS_channel; pfam00924 436717008250 Predicted membrane protein (DUF2339); Region: DUF2339; pfam10101 436717008251 DNA polymerase I; Provisional; Region: PRK05755 436717008252 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 436717008253 active site 436717008254 metal binding site 1 [ion binding]; metal-binding site 436717008255 putative 5' ssDNA interaction site; other site 436717008256 metal binding site 3; metal-binding site 436717008257 metal binding site 2 [ion binding]; metal-binding site 436717008258 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 436717008259 putative DNA binding site [nucleotide binding]; other site 436717008260 putative metal binding site [ion binding]; other site 436717008261 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 436717008262 active site 436717008263 catalytic site [active] 436717008264 substrate binding site [chemical binding]; other site 436717008265 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 436717008266 active site 436717008267 DNA binding site [nucleotide binding] 436717008268 catalytic site [active] 436717008269 YGGT family; Region: YGGT; cl00508 436717008270 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 436717008271 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 436717008272 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 436717008273 TilS substrate binding domain; Region: TilS; pfam09179 436717008274 B3/4 domain; Region: B3_4; cl11458 436717008275 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl00513 436717008276 guanosine pentaphosphate phosphohydrolase; Provisional; Region: PRK11031 436717008277 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 436717008278 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 436717008279 catalytic residues [active] 436717008280 transcription termination factor Rho; Provisional; Region: rho; PRK09376 436717008281 Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498 436717008282 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent...; Region: Rho_CSD; cd04459 436717008283 RNA binding site [nucleotide binding]; other site 436717008284 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of...; Region: rho_factor; cd01128 436717008285 multimer interface [polypeptide binding]; other site 436717008286 Walker A motif; other site 436717008287 ATP binding site [chemical binding]; other site 436717008288 Walker B motif; other site 436717008289 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and higher-...; Region: HU_IHF; cd00591 436717008290 IHF dimer interface [polypeptide binding]; other site 436717008291 IHF - DNA interface [nucleotide binding]; other site 436717008292 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 436717008293 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 436717008294 putative tRNA-binding site [nucleotide binding]; other site 436717008295 B3/4 domain; Region: B3_4; cl11458 436717008296 tRNA synthetase B5 domain; Region: B5; cl08394 436717008297 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 436717008298 dimer interface [polypeptide binding]; other site 436717008299 motif 1; other site 436717008300 motif 3; other site 436717008301 motif 2; other site 436717008302 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 436717008303 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 436717008304 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 436717008305 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 436717008306 dimer interface [polypeptide binding]; other site 436717008307 motif 1; other site 436717008308 active site 436717008309 motif 2; other site 436717008310 motif 3; other site 436717008311 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 436717008312 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 436717008313 Coenzyme A binding pocket [chemical binding]; other site 436717008314 Domain of unknown function (DUF1768); Region: DUF1768; cl01271 436717008315 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 436717008316 23S rRNA binding site [nucleotide binding]; other site 436717008317 L21 binding site [polypeptide binding]; other site 436717008318 L13 binding site [polypeptide binding]; other site 436717008319 Ribosomal protein L35; Region: Ribosomal_L35p; cl00392 436717008320 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 436717008321 putative substrate translocation pore; other site 436717008322 H+ Antiporter protein; Region: 2A0121; TIGR00900 436717008323 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 436717008324 GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972 436717008325 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen...; Region: GST_N_Ure2p_like; cd03048 436717008326 C-terminal domain interface [polypeptide binding]; other site 436717008327 GSH binding site (G-site) [chemical binding]; other site 436717008328 dimer interface [polypeptide binding]; other site 436717008329 GST_C family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen...; Region: GST_C_Ure2p_like; cd03178 436717008330 dimer interface [polypeptide binding]; other site 436717008331 N-terminal domain interface [polypeptide binding]; other site 436717008332 putative substrate binding pocket (H-site) [chemical binding]; other site 436717008333 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 436717008334 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 436717008335 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase...; Region: TGS_ThrRS_N; cd01667 436717008336 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 436717008337 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 436717008338 active site 436717008339 dimer interface [polypeptide binding]; other site 436717008340 motif 1; other site 436717008341 motif 2; other site 436717008342 motif 3; other site 436717008343 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 436717008344 anticodon binding site; other site 436717008345 acyl-CoA synthetase; Validated; Region: PRK08162 436717008346 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 436717008347 Protein of unknown function (DUF615); Region: DUF615; cl01147 436717008348 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 436717008349 dimerization domain swap beta strand [polypeptide binding]; other site 436717008350 regulatory protein interface [polypeptide binding]; other site 436717008351 active site 436717008352 regulatory phosphorylation site [posttranslational modification]; other site 436717008353 P-loop ATPase protein family; Region: ATP_bind_2; cl10035 436717008354 pantoate--beta-alanine ligase; Region: panC; TIGR00018 436717008355 Pantoate-beta-alanine ligase; Region: PanC; cd00560 436717008356 active site 436717008357 ATP-binding site [chemical binding]; other site 436717008358 pantoate-binding site; other site 436717008359 HXXH motif; other site 436717008360 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 436717008361 oligomerization interface [polypeptide binding]; other site 436717008362 active site 436717008363 metal binding site [ion binding]; metal-binding site 436717008364 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 436717008365 catalytic center binding site [active] 436717008366 ATP binding site [chemical binding]; other site 436717008367 poly(A) polymerase; Region: pcnB; TIGR01942 436717008368 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 436717008369 active site 436717008370 NTP binding site [chemical binding]; other site 436717008371 metal binding triad [ion binding]; metal-binding site 436717008372 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 436717008373 Polymerase A arginine-rich C-terminus; Region: PolyA_pol_arg_C; pfam12626 436717008374 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 436717008375 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 436717008376 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 436717008377 MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345 436717008378 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 436717008379 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 436717008380 NAD(P) binding site [chemical binding]; other site 436717008381 active site 436717008382 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 436717008383 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 436717008384 synthetase active site [active] 436717008385 NTP binding site [chemical binding]; other site 436717008386 metal binding site [ion binding]; metal-binding site 436717008387 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named...; Region: TGS_RelA_SpoT; cd01668 436717008388 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 436717008389 23S rRNA m(5)U1939 methyltransferase; Reviewed; Region: rumA; PRK13168 436717008390 TRAM domain; Region: TRAM; cl01282 436717008391 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 436717008392 Uncharacterized bacterial subgroup of the DEDDy 3'-5' exonuclease domain of family-B DNA polymerases; Region: DNA_polB_like1_exo; cd05782 436717008393 active site 436717008394 catalytic site [active] 436717008395 substrate binding site [chemical binding]; other site 436717008396 Predicted 3'-5' exonuclease related to the exonuclease domain of PolB; Region: DNA_pol_B_exo2; pfam10108 436717008397 cysteine synthases; Region: cysKM; TIGR01136 436717008398 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine...; Region: CBS_like; cd01561 436717008399 dimer interface [polypeptide binding]; other site 436717008400 pyridoxal 5'-phosphate binding site [chemical binding]; other site 436717008401 catalytic residue [active] 436717008402 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 436717008403 dimer interface [polypeptide binding]; other site 436717008404 phosphorylation site [posttranslational modification] 436717008405 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 436717008406 ATP binding site [chemical binding]; other site 436717008407 Mg2+ binding site [ion binding]; other site 436717008408 G-X-G motif; other site 436717008409 Response regulator receiver domain; Region: Response_reg; pfam00072 436717008410 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 436717008411 active site 436717008412 phosphorylation site [posttranslational modification] 436717008413 intermolecular recognition site; other site 436717008414 dimerization interface [polypeptide binding]; other site 436717008415 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086 436717008416 enoyl-CoA hydratase; Provisional; Region: PRK07509 436717008417 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 436717008418 substrate binding site [chemical binding]; other site 436717008419 oxyanion hole (OAH) forming residues; other site 436717008420 trimer interface [polypeptide binding]; other site 436717008421 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 436717008422 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 436717008423 hydroxypyruvate isomerase; Region: OH-pyruv-isom; TIGR03234 436717008424 Domain of unknown function DUF143; Region: DUF143; cl00519 436717008425 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 436717008426 putative NAD(P) binding site [chemical binding]; other site 436717008427 active site 436717008428 NAD(P) transhydrogenase beta subunit; Region: PNTB; cl00566 436717008429 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 436717008430 NAD(P) transhydrogenase subunit alpha; Provisional; Region: pntA; PRK09424 436717008431 Alanine dehydrogenase/PNT, N-terminal domain; Region: AlaDh_PNT_N; pfam05222 436717008432 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl14614 436717008433 EamA-like transporter family; Region: EamA; cl01037 436717008434 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 436717008435 EamA-like transporter family; Region: EamA; cl01037 436717008436 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 436717008437 homotrimer interaction site [polypeptide binding]; other site 436717008438 putative active site [active] 436717008439 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 436717008440 putative substrate translocation pore; other site 436717008441 tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815 436717008442 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and...; Region: DUS_like_FMN; cd02801 436717008443 FMN binding site [chemical binding]; other site 436717008444 active site 436717008445 catalytic residues [active] 436717008446 substrate binding site [chemical binding]; other site 436717008447 Transcriptional regulator [Transcription]; Region: LysR; COG0583 436717008448 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 436717008449 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 436717008450 dimerization interface [polypeptide binding]; other site 436717008451 substrate binding pocket [chemical binding]; other site 436717008452 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179 436717008453 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-...; Region: YgdL_like; cd00755 436717008454 putative ATP binding site [chemical binding]; other site 436717008455 putative substrate interface [chemical binding]; other site 436717008456 aconitate hydratase; Validated; Region: PRK09277 436717008457 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 436717008458 substrate binding site [chemical binding]; other site 436717008459 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 436717008460 ligand binding site [chemical binding]; other site 436717008461 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 436717008462 substrate binding site [chemical binding]; other site 436717008463 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 436717008464 putative deoxyribonuclease YjjV; Provisional; Region: PRK11449 436717008465 active site 436717008466 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 436717008467 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 436717008468 RF3 subfamily. Peptide chain release factor 3 (RF3) is a protein involved in the termination step of translation in bacteria. Termination occurs when class I release factors (RF1 or RF2) recognize the stop codon at the A-site of the ribosome and...; Region: RF3; cd04169 436717008469 G1 box; other site 436717008470 putative GEF interaction site [polypeptide binding]; other site 436717008471 GTP/Mg2+ binding site [chemical binding]; other site 436717008472 Switch I region; other site 436717008473 G2 box; other site 436717008474 G3 box; other site 436717008475 Switch II region; other site 436717008476 G4 box; other site 436717008477 G5 box; other site 436717008478 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 436717008479 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 436717008480 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 436717008481 MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300 436717008482 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 436717008483 metal binding site [ion binding]; metal-binding site 436717008484 active site 436717008485 I-site; other site 436717008486 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 436717008487 ketol-acid reductoisomerase; Provisional; Region: PRK05479 436717008488 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 436717008489 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 436717008490 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 436717008491 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 436717008492 putative valine binding site [chemical binding]; other site 436717008493 dimer interface [polypeptide binding]; other site 436717008494 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 436717008495 acetolactate synthase 3 catalytic subunit; Validated; Region: PRK06466 436717008496 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 436717008497 PYR/PP interface [polypeptide binding]; other site 436717008498 dimer interface [polypeptide binding]; other site 436717008499 TPP binding site [chemical binding]; other site 436717008500 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 436717008501 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 436717008502 TPP-binding site [chemical binding]; other site 436717008503 dimer interface [polypeptide binding]; other site 436717008504 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 436717008505 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 436717008506 HIGH motif; other site 436717008507 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 436717008508 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 436717008509 active site 436717008510 KMSKS motif; other site 436717008511 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 436717008512 tRNA binding surface [nucleotide binding]; other site 436717008513 Lipopolysaccharide-assembly; Region: LptE; cl01125 436717008514 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 436717008515 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 436717008516 macrolide transporter subunit MacA; Provisional; Region: PRK11578 436717008517 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2...; Region: Biotinyl_lipoyl_domains; cl11404 436717008518 lipoyl-biotinyl attachment site [posttranslational modification]; other site 436717008519 macrolide transporter ATP-binding /permease protein; Provisional; Region: PRK10535 436717008520 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 436717008521 Walker A/P-loop; other site 436717008522 ATP binding site [chemical binding]; other site 436717008523 Q-loop/lid; other site 436717008524 ABC transporter signature motif; other site 436717008525 Walker B; other site 436717008526 D-loop; other site 436717008527 H-loop/switch region; other site 436717008528 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 436717008529 FtsX-like permease family; Region: FtsX; pfam02687 436717008530 NodT family; Region: outer_NodT; TIGR01845 436717008531 Outer membrane efflux protein; Region: OEP; pfam02321 436717008532 Outer membrane efflux protein; Region: OEP; pfam02321 436717008533 Enoyl-[acyl-carrier-protein]; Region: FabI; COG0623 436717008534 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 436717008535 NAD binding site [chemical binding]; other site 436717008536 homotetramer interface [polypeptide binding]; other site 436717008537 homodimer interface [polypeptide binding]; other site 436717008538 substrate binding site [chemical binding]; other site 436717008539 active site 436717008540 BAX inhibitor (BI)-1 like protein family. Mammalian members of this family of small transmembrane proteins have been shown to have an antiapoptotic effect either by stimulating the antiapoptotic function of Bcl-2, a well characterized oncogene, or...; Region: BI-1-like; cl00473 436717008541 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 436717008542 putative active site [active] 436717008543 putative substrate binding site [chemical binding]; other site 436717008544 catalytic site [active] 436717008545 dimer interface [polypeptide binding]; other site 436717008546 GTPase RsgA; Reviewed; Region: PRK12288 436717008547 YjeQ/EngC. YjeQ (YloQ in Bacillus subtilis) represents a protein family whose members are broadly conserved in bacteria and have been shown to be essential to the growth of E. coli and B. subtilis. Proteins of the YjeQ family contain all sequence...; Region: YjeQ_engC; cd01854 436717008548 GTPase/OB domain interface [polypeptide binding]; other site 436717008549 GTPase/Zn-binding domain interface [polypeptide binding]; other site 436717008550 GTP/Mg2+ binding site [chemical binding]; other site 436717008551 G4 box; other site 436717008552 G5 box; other site 436717008553 G1 box; other site 436717008554 Switch I region; other site 436717008555 G2 box; other site 436717008556 G3 box; other site 436717008557 Switch II region; other site 436717008558 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 436717008559 active site residue [active] 436717008560 Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418 436717008561 GSH binding site [chemical binding]; other site 436717008562 catalytic residues [active] 436717008563 Preprotein translocase subunit SecB. SecB is a cytoplasmic component of the multisubunit membrane-bound enzyme termed Sec protein translocase, which is the main constituent of the General Secretory (type II) Pathway involved in translocation of nascent...; Region: Translocase_SecB; cl00251 436717008564 SecA binding site; other site 436717008565 Preprotein binding site; other site 436717008566 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 436717008567 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500 436717008568 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK09116 436717008569 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 436717008570 dimer interface [polypeptide binding]; other site 436717008571 active site 436717008572 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 436717008573 3-oxoacyl-(acyl-carrier-protein) reductase, putative; Region: fabG_rel; TIGR01831 436717008574 NAD(P) binding site [chemical binding]; other site 436717008575 homotetramer interface [polypeptide binding]; other site 436717008576 homodimer interface [polypeptide binding]; other site 436717008577 active site 436717008578 Domain of unknown function, appears to be related to a diverse group of beta-hydroxydecanoyl ACP dehydratases (FabA) and beta-hydroxyacyl ACP dehydratases (FabZ). This group appears to lack the conserved active site histidine of FabA and FabZ; Region: FabA_like; cd01289 436717008579 putative active site 1 [active] 436717008580 3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK09185 436717008581 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 436717008582 dimer interface [polypeptide binding]; other site 436717008583 active site 436717008584 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 436717008585 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 436717008586 Predicted exporter [General function prediction only]; Region: COG4258 436717008587 Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl01065 436717008588 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active...; Region: 4HBT; cd00586 436717008589 active site 436717008590 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 436717008591 tyrosine 2,3-aminomutase; Region: Tyr_2_3_mutase; TIGR03832 436717008592 active sites [active] 436717008593 tetramer interface [polypeptide binding]; other site 436717008594 Predicted acyltransferase [General function prediction only]; Region: COG4261 436717008595 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 436717008596 putative acyl-acceptor binding pocket; other site 436717008597 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 436717008598 Ligand binding site [chemical binding]; other site 436717008599 Putative Catalytic site [active] 436717008600 DXD motif; other site 436717008601 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 436717008602 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 436717008603 Predicted membrane protein [Function unknown]; Region: COG4648 436717008604 Phosphopantetheine attachment site; Region: PP-binding; cl09936 436717008605 Phosphopantetheine attachment site; Region: PP-binding; cl09936 436717008606 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 436717008607 putative acyl-acceptor binding pocket; other site 436717008608 GTP-binding protein Der; Reviewed; Region: PRK00093 436717008609 EngA1 subfamily. This CD represents the first GTPase domain of EngA and its orthologs, which are composed of two adjacent GTPase domains. Since the sequences of the two domains are more similar to each other than to other GTPases, it is likely that...; Region: EngA1; cd01894 436717008610 G1 box; other site 436717008611 GTP/Mg2+ binding site [chemical binding]; other site 436717008612 Switch I region; other site 436717008613 G2 box; other site 436717008614 Switch II region; other site 436717008615 G3 box; other site 436717008616 G4 box; other site 436717008617 G5 box; other site 436717008618 EngA2 subfamily. This CD represents the second GTPase domain of EngA and its orthologs, which are composed of two adjacent GTPase domains. Since the sequences of the two domains are more similar to each other than to other GTPases, it is likely that...; Region: EngA2; cd01895 436717008619 G1 box; other site 436717008620 GTP/Mg2+ binding site [chemical binding]; other site 436717008621 Switch I region; other site 436717008622 G2 box; other site 436717008623 G3 box; other site 436717008624 Switch II region; other site 436717008625 G4 box; other site 436717008626 G5 box; other site 436717008627 outer membrane assembly lipoprotein YfgL; Region: assembly_YfgL; TIGR03300 436717008628 Dehydrogenases with pyrrolo-quinoline quinone (PQQ) as cofactor, like ethanol, methanol, and membrane bound glucose dehydrogenases. The alignment model contains an 8-bladed beta-propeller; Region: PQQ_DH; cl11493 436717008629 Dehydrogenases with pyrrolo-quinoline quinone (PQQ) as cofactor, like ethanol, methanol, and membrane bound glucose dehydrogenases. The alignment model contains an 8-bladed beta-propeller; Region: PQQ_DH; cl11493 436717008630 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2976 436717008631 Uncharacterized protein conserved in bacteria (DUF2133); Region: DUF2133; pfam09976 436717008632 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 436717008633 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: HisRS-like_core; cd00773 436717008634 dimer interface [polypeptide binding]; other site 436717008635 motif 1; other site 436717008636 active site 436717008637 motif 2; other site 436717008638 motif 3; other site 436717008639 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 436717008640 anticodon binding site; other site 436717008641 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 436717008642 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase; Region: ispG_gcpE; TIGR00612 436717008643 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl09100 436717008644 cytoskeletal protein RodZ; Provisional; Region: PRK10856 436717008645 type IV pilus biogenesis/stability protein PilW; Region: type_IV_pilW; TIGR02521 436717008646 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 436717008647 TPR motif; other site 436717008648 binding surface 436717008649 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK11194 436717008650 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 436717008651 FeS/SAM binding site; other site 436717008652 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 436717008653 active site 436717008654 multimer interface [polypeptide binding]; other site 436717008655 Protein of unknown function (DUF528); Region: DUF528; cl01123 436717008656 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 436717008657 active site 436717008658 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 436717008659 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule...; Region: GT1_like_2; cd03814 436717008660 carboxy-terminal protease; Provisional; Region: PRK11186 436717008661 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 436717008662 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 436717008663 protein binding site [polypeptide binding]; other site 436717008664 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 436717008665 Catalytic dyad [active] 436717008666 C-terminal domain of tail specific protease (DUF3340); Region: DUF3340; pfam11818 436717008667 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 436717008668 Leucine carboxyl methyltransferase; Region: LCM; cl01306 436717008669 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 436717008670 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 436717008671 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 436717008672 putative catalytic cysteine [active] 436717008673 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 436717008674 Gluconate kinase [Carbohydrate transport and metabolism]; Region: GntK; COG3265 436717008675 ATP-binding site [chemical binding]; other site 436717008676 Gluconate-6-phosphate binding site [chemical binding]; other site 436717008677 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110 436717008678 gluconate transporter; Region: gntP; TIGR00791 436717008679 keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718 436717008680 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 436717008681 active site 436717008682 intersubunit interface [polypeptide binding]; other site 436717008683 catalytic residue [active] 436717008684 Dehydratase family; Region: ILVD_EDD; cl00340 436717008685 6-phosphogluconate dehydratase; Region: edd; TIGR01196 436717008686 Acetokinase family; Region: Acetate_kinase; cl01029 436717008687 phosphate acetyltransferase; Reviewed; Region: PRK05632 436717008688 DRTGG domain; Region: DRTGG; cl12147 436717008689 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390 436717008690 Fumarate hydratase (Fumerase); Region: Fumerase; cl00851 436717008691 Fumarase C-terminus; Region: Fumerase_C; cl00795 436717008692 Uncharacterized protein conserved in bacteria (DUF2059); Region: DUF2059; cl01243 436717008693 Protein of unknown function (DUF2846); Region: DUF2846; pfam11008 436717008694 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 436717008695 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 436717008696 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 436717008697 Walker A motif; other site 436717008698 ATP binding site [chemical binding]; other site 436717008699 Walker B motif; other site 436717008700 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 436717008701 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 436717008702 oligomer interface [polypeptide binding]; other site 436717008703 active site residues [active] 436717008704 trigger factor; Provisional; Region: tig; PRK01490 436717008705 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587 436717008706 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 436717008707 Outer membrane receptor for monomeric catechols [Inorganic ion transport and metabolism]; Region: Fiu; COG4774 436717008708 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 436717008709 N-terminal plug; other site 436717008710 ligand-binding site [chemical binding]; other site 436717008711 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; cl01206 436717008712 2-isopropylmalate synthase; Validated; Region: PRK03739 436717008713 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 436717008714 active site 436717008715 catalytic residues [active] 436717008716 metal binding site [ion binding]; metal-binding site 436717008717 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502 436717008718 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 436717008719 Homoserine acetyltransferase [Amino acid transport and metabolism]; Region: MET2; COG2021 436717008720 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 436717008721 S-adenosylmethionine binding site [chemical binding]; other site 436717008722 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 436717008723 Sel1 repeat; Region: Sel1; cl02723 436717008724 Sel1 repeat; Region: Sel1; cl02723 436717008725 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A Ham1-...; Region: HAM1; cd00515 436717008726 active site 436717008727 dimerization interface [polypeptide binding]; other site 436717008728 potential frameshift: common BLAST hit: gi|169634435|ref|YP_001708171.1| putative permease 436717008729 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 436717008730 sec-independent translocase; Provisional; Region: tatB; PRK00404 436717008731 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 436717008732 Sec-independent protein translocase protein (TatC); Region: TatC; cl00521 436717008733 Bacterial protein of unknown function (DUF839); Region: DUF839; pfam05787 436717008734 Predicted phosphatase [General function prediction only]; Region: PhoX; COG3211 436717008735 Protein of unknown function (DUF833); Region: DUF833; cl01315 436717008736 Prolipoprotein diacylglyceryl transferase; Region: LGT; cl00478 436717008737 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 436717008738 dimerization interface [polypeptide binding]; other site 436717008739 active site 436717008740 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5,10-...; Region: DHFR; cd00209 436717008741 folate binding site [chemical binding]; other site 436717008742 NADP+ binding site [chemical binding]; other site 436717008743 Peptide methionine sulfoxide reductase; Region: PMSR; cl00366 436717008744 Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537 436717008745 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 436717008746 Protein of unknown function (DUF2869); Region: DUF2869; pfam11068 436717008747 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 436717008748 Gram-negative bacterial tonB protein; Region: TonB; cl10048 436717008749 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 436717008750 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 436717008751 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 436717008752 putative active site [active] 436717008753 putative substrate binding site [chemical binding]; other site 436717008754 putative cosubstrate binding site; other site 436717008755 catalytic site [active] 436717008756 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 436717008757 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 436717008758 Coniferyl aldehyde dehydrogenase-like; Region: ALDH_CALDH_CalB; cd07133 436717008759 NAD(P) binding site [chemical binding]; other site 436717008760 catalytic residues [active] 436717008761 Ribosomal L28 family; Region: Ribosomal_L28; cl00367 436717008762 Ribosomal protein L33; Region: Ribosomal_L33; cl00383 436717008763 putative cation:proton antiport protein; Provisional; Region: PRK10669 436717008764 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 436717008765 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 436717008766 ASC-1 homology or ASCH domain, a small beta-barrel domain found in all three kingdoms of life. ASCH resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as an RNA-binding domain during coactivation...; Region: ASCH; cl01020 436717008767 RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA...; Region: RRM; cd00590 436717008768 RNA/DNA binding site [nucleotide binding]; other site 436717008769 RRM dimerization site [polypeptide binding]; other site 436717008770 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 436717008771 UvrD/REP helicase; Region: UvrD-helicase; cl14126 436717008772 Uncharacterized conserved protein [Function unknown]; Region: HdeD; cl01277 436717008773 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 436717008774 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in...; Region: TOPRIM_TopoIA_TopoI; cd03363 436717008775 active site 436717008776 interdomain interaction site; other site 436717008777 putative metal-binding site [ion binding]; other site 436717008778 nucleotide binding site [chemical binding]; other site 436717008779 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded...; Region: TOP1Ac; cd00186 436717008780 domain I; other site 436717008781 DNA binding groove [nucleotide binding] 436717008782 phosphate binding site [ion binding]; other site 436717008783 domain II; other site 436717008784 domain III; other site 436717008785 nucleotide binding site [chemical binding]; other site 436717008786 catalytic site [active] 436717008787 domain IV; other site 436717008788 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; cl11977 436717008789 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; cl11977 436717008790 Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272 436717008791 Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272 436717008792 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 436717008793 Arginate lyase and other MDR family members; Region: AL_MDR; cd08252 436717008794 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817 436717008795 putative NAD(P) binding site [chemical binding]; other site 436717008796 dimer interface [polypeptide binding]; other site 436717008797 SlyX; Region: SlyX; cl01090 436717008798 ABC transporter ATPase component; Reviewed; Region: PRK11147 436717008799 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 436717008800 Walker A/P-loop; other site 436717008801 ATP binding site [chemical binding]; other site 436717008802 Q-loop/lid; other site 436717008803 ABC transporter signature motif; other site 436717008804 Walker B; other site 436717008805 D-loop; other site 436717008806 H-loop/switch region; other site 436717008807 ABC transporter; Region: ABC_tran_2; pfam12848 436717008808 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by...; Region: ABCF_EF-3; cd03221 436717008809 LysE type translocator; Region: LysE; cl00565 436717008810 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 436717008811 putative acyl-acceptor binding pocket; other site 436717008812 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 436717008813 This family is most closely related to the GT1 family of glycosyltransferases. WavL in Vibrio cholerae has been shown to be involved in the biosynthesis of the lipopolysaccharide core; Region: GT1_WavL_like; cd03819 436717008814 putative ADP-binding pocket [chemical binding]; other site 436717008815 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 436717008816 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 436717008817 putative catalytic site [active] 436717008818 putative metal binding site [ion binding]; other site 436717008819 putative phosphate binding site [ion binding]; other site 436717008820 aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK06598 436717008821 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 436717008822 Semialdehyde dehydrogenase, dimerisation domain; Region: Semialdhyde_dhC; pfam02774 436717008823 Tfp pilus assembly protein FimV [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimV; COG3170 436717008824 Tfp pilus assembly protein FimV [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimV; COG3170 436717008825 FimV N-terminal domain; Region: FimV_core; TIGR03505 436717008826 Asparaginase (amidohydrolase): Asparaginases are tetrameric enzymes that catalyze the hydrolysis of asparagine to aspartic acid and ammonia. In bacteria, there are two classes of amidohydrolases, one highly specific for asparagine and localised to the...; Region: Asparaginase; cl00216 436717008827 active site/substrate binding site [active] 436717008828 tetramer interface [polypeptide binding]; other site 436717008829 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 436717008830 PseudoU_synth_EcTruA: Pseudouridine synthase, Escherichia coli TruA like. This group consists of eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA, Pseudomonas aeruginosa truA and human pseudouridine synthase-like 1 (PUSL1)...; Region: PseudoU_synth_EcTruA; cd02570 436717008831 dimerization interface 3.5A [polypeptide binding]; other site 436717008832 active site 436717008833 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 436717008834 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 436717008835 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 436717008836 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 436717008837 rRNA binding site [nucleotide binding]; other site 436717008838 predicted 30S ribosome binding site; other site 436717008839 Protein of unknown function (DUF1311); Region: DUF1311; cl01530 436717008840 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 436717008841 isocitrate dehydrogenase; Validated; Region: PRK06451 436717008842 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate 3-...; Region: IPMI_Swivel; cd01577 436717008843 substrate binding site [chemical binding]; other site 436717008844 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 436717008845 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 436717008846 substrate binding site [chemical binding]; other site 436717008847 ligand binding site [chemical binding]; other site 436717008848 Predicted membrane protein (DUF2061); Region: DUF2061; cl01257 436717008849 Transcriptional regulator [Transcription]; Region: LysR; COG0583 436717008850 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 436717008851 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 436717008852 dimerization interface [polypeptide binding]; other site 436717008853 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 436717008854 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where...; Region: Ap4A_hydrolase_plant_like; cd03671 436717008855 putative active site [active] 436717008856 Ap4A binding site [chemical binding]; other site 436717008857 nudix motif; other site 436717008858 putative metal binding site [ion binding]; other site 436717008859 Signal transduction protein containing GAF and PtsI domains [Signal transduction mechanisms]; Region: PtsP; COG3605 436717008860 GAF domain; Region: GAF; cl00853 436717008861 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 436717008862 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 436717008863 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 436717008864 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 436717008865 Heme-dependent peroxidases similar to plant peroxidases; Region: plant_peroxidase_like; cl00196 436717008866 heme binding site [chemical binding]; other site 436717008867 Heme-dependent peroxidases similar to plant peroxidases; Region: plant_peroxidase_like; cl00196 436717008868 heme binding site [chemical binding]; other site 436717008869 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 436717008870 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 436717008871 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 436717008872 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 436717008873 dimerization interface [polypeptide binding]; other site 436717008874 Protein of unknown function (DUF1345); Region: DUF1345; cl01753 436717008875 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 436717008876 GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins...; Region: GST_N_GTT1_like; cd03046 436717008877 putative C-terminal domain interface [polypeptide binding]; other site 436717008878 putative GSH binding site (G-site) [chemical binding]; other site 436717008879 putative dimer interface [polypeptide binding]; other site 436717008880 GST_C family, unknown subfamily 8; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_C_8; cd03207 436717008881 putative N-terminal domain interface [polypeptide binding]; other site 436717008882 putative dimer interface [polypeptide binding]; other site 436717008883 putative substrate binding pocket (H-site) [chemical binding]; other site 436717008884 Predicted transcriptional regulator [Transcription]; Region: COG2378 436717008885 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 436717008886 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 436717008887 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 436717008888 motif II; other site 436717008889 23S rRNA pseudouridylate synthase C; Provisional; Region: PRK11025 436717008890 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 436717008891 PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF...; Region: PseudoU_synth_RluCD_like; cd02869 436717008892 active site 436717008893 ribonuclease E; Reviewed; Region: rne; PRK10811 436717008894 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 436717008895 homodimer interface [polypeptide binding]; other site 436717008896 oligonucleotide binding site [chemical binding]; other site 436717008897 long-chain-acyl-CoA synthetase; Validated; Region: PRK08279 436717008898 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 436717008899 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 436717008900 Transcriptional regulator [Transcription]; Region: LysR; COG0583 436717008901 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 436717008902 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 436717008903 putative effector binding pocket; other site 436717008904 putative dimerization interface [polypeptide binding]; other site 436717008905 short chain dehydrogenase; Provisional; Region: PRK12744 436717008906 tetrahydroxynaphthalene/trihydroxynaphthalene reductase-like, classical (c) SDRs; Region: THN_reductase-like_SDR_c; cd05362 436717008907 NADP binding site [chemical binding]; other site 436717008908 homodimer interface [polypeptide binding]; other site 436717008909 active site 436717008910 substrate binding site [chemical binding]; other site 436717008911 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 436717008912 HemN family oxidoreductase; Provisional; Region: PRK05660 436717008913 FeS/SAM binding site; other site 436717008914 HemN C-terminal region; Region: HemN_C; pfam06969 436717008915 Protein of unknown function, DUF606; Region: DUF606; cl01273 436717008916 multidrug efflux protein; Reviewed; Region: PRK01766 436717008917 MatE; Region: MatE; pfam01554 436717008918 MatE; Region: MatE; pfam01554 436717008919 Dibenzothiophene (DBT) desulfurization enzyme C; Region: DszC; cd01163 436717008920 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 436717008921 Flavin binding site [chemical binding]; other site 436717008922 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 436717008923 Dibenzothiophene (DBT) desulfurization enzyme C; Region: DszC; cd01163 436717008924 Flavin binding site [chemical binding]; other site 436717008925 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 436717008926 Ribosomal protein L31; Region: Ribosomal_L31; cl00377 436717008927 HopJ type III effector protein; Region: HopJ; pfam08888 436717008928 CrcB-like protein; Region: CRCB; cl09114 436717008929 Glutathione-dependent formaldehyde-activating enzyme; Region: GFA; cl01553 436717008930 Predicted flavoproteins [General function prediction only]; Region: COG2081 436717008931 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 436717008932 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 436717008933 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 436717008934 Domain of unknown function (DUF329); Region: DUF329; cl01144 436717008935 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 436717008936 ferrochelatase; Reviewed; Region: hemH; PRK00035 436717008937 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 436717008938 C-terminal domain interface [polypeptide binding]; other site 436717008939 active site 436717008940 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 436717008941 active site 436717008942 N-terminal domain interface [polypeptide binding]; other site 436717008943 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 436717008944 aspartate racemase; Region: asp_race; TIGR00035 436717008945 Protein of unknown function (DUF1285); Region: DUF1285; cl01571 436717008946 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 436717008947 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 436717008948 Electron transfer flavoprotein-ubiquinone oxidoreductase; Region: ETF_QO; pfam05187 436717008949 SirA (also known as UvrY, and YhhP) belongs to a family of two-component response regulators that controls secondary metabolism and virulence. The other member of this two-component system is a sensor kinase called BarA which phosphorylates SirA. A...; Region: SirA; cd03423 436717008950 CPxP motif; other site 436717008951 Putative Mg2+ and Co2+ transporter CorC [Inorganic ion transport and metabolism]; Region: CorC; COG4535 436717008952 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 436717008953 Transporter associated domain; Region: CorC_HlyC; pfam03471 436717008954 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 436717008955 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 436717008956 putative active site [active] 436717008957 catalytic triad [active] 436717008958 putative dimer interface [polypeptide binding]; other site 436717008959 tRNA-binding-domain-containing CsaA-like proteins. CsaA is a molecular chaperone with export related activities. CsaA has a putative tRNA binding activity. The functional unit of CsaA is a homodimer and this domain acts as a dimerization domain; Region: tRNA_bind_CsaA; cd02798 436717008960 dimer interface [polypeptide binding]; other site 436717008961 putative tRNA-binding site [nucleotide binding]; other site 436717008962 Protein of unknown function (DUF2798); Region: DUF2798; pfam11391 436717008963 general secretion pathway protein G; Region: typeII_sec_gspG; TIGR01710 436717008964 Bacterial type II secretion system protein G; Region: GSPII_G; pfam08334 436717008965 general secretion pathway protein F; Region: GspF; TIGR02120 436717008966 Bacterial type II secretion system protein F domain; Region: GSPII_F; cl00906 436717008967 Bacterial type II secretion system protein F domain; Region: GSPII_F; cl00906 436717008968 primosome assembly protein PriA; Validated; Region: PRK05580 436717008969 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 436717008970 ATP binding site [chemical binding]; other site 436717008971 putative Mg++ binding site [ion binding]; other site 436717008972 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl14882 436717008973 glutathione-regulated potassium-efflux system protein KefC; Provisional; Region: PRK03562 436717008974 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 436717008975 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 436717008976 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 436717008977 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 436717008978 dimerization interface [polypeptide binding]; other site 436717008979 domain crossover interface; other site 436717008980 redox-dependent activation switch; other site 436717008981 LysE type translocator; Region: LysE; cl00565 436717008982 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of...; Region: DnaJ; cd06257 436717008983 chaperone protein DnaJ; Region: DnaJ_bact; TIGR02349 436717008984 HSP70 interaction site [polypeptide binding]; other site 436717008985 DnaJ C terminal domain; Region: DnaJ_C; pfam01556 436717008986 DnaJ C terminal domain; Region: DnaJ_C; pfam01556 436717008987 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 436717008988 magnesium/nickel/cobalt transporter CorA; Provisional; Region: PRK11085; cl00459 436717008989 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 436717008990 3' exoribonuclease family, domain 1; Region: RNase_PH; pfam01138 436717008991 3' exoribonuclease family, domain 2; Region: RNase_PH_C; pfam03725 436717008992 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 436717008993 3' exoribonuclease family, domain 1; Region: RNase_PH; pfam01138 436717008994 3' exoribonuclease family, domain 2; Region: RNase_PH_C; pfam03725 436717008995 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 436717008996 putative nucleic acid binding region [nucleotide binding]; other site 436717008997 G-X-X-G motif; other site 436717008998 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA...; Region: S1_PNPase; cd04472 436717008999 RNA binding site [nucleotide binding]; other site 436717009000 domain interface; other site 436717009001 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole...; Region: Ribosomal_S15p_S13e; cd00353 436717009002 16S/18S rRNA binding site [nucleotide binding]; other site 436717009003 S13e-L30e interaction site [polypeptide binding]; other site 436717009004 25S rRNA binding site [nucleotide binding]; other site 436717009005 Beta-lactamase; Region: Beta-lactamase; cl01009 436717009006 exodeoxyribonuclease V, alpha subunit; Region: recD; TIGR01447 436717009007 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl14882 436717009008 ATP binding site [chemical binding]; other site 436717009009 putative Mg++ binding site [ion binding]; other site 436717009010 UvrD/REP helicase; Region: UvrD-helicase; cl14126 436717009011 ATP-dependent exoDNAse (exonuclease V) beta subunit (contains helicase and exonuclease domains) [DNA replication, recombination, and repair]; Region: RecB; COG1074 436717009012 UvrD/REP helicase; Region: UvrD-helicase; cl14126 436717009013 exodeoxyribonuclease V, gamma subunit; Region: recC; TIGR01450 436717009014 exonuclease V subunit gamma; Provisional; Region: recC; PRK11069 436717009015 Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971 436717009016 polyphosphate:AMP phosphotransferase; Region: poly_P_AMP_trns; TIGR03708 436717009017 Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971 436717009018 ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209 436717009019 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 436717009020 S-adenosylmethionine binding site [chemical binding]; other site 436717009021 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 436717009022 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3165 436717009023 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 436717009024 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 436717009025 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 436717009026 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 436717009027 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 436717009028 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_2; cd07253 436717009029 dimer interface [polypeptide binding]; other site 436717009030 metal binding site [ion binding]; metal-binding site 436717009031 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 436717009032 Phosphoribosyl-AMP cyclohydrolase; Region: PRA-CH; cl00344 436717009033 MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345 436717009034 DNA helicase II; Region: uvrD; TIGR01075 436717009035 UvrD/REP helicase; Region: UvrD-helicase; cl14126 436717009036 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 436717009037 Predicted ATP-binding protein involved in virulence [General function prediction only]; Region: COG3950 436717009038 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 436717009039 ABC transporter signature motif; other site 436717009040 Walker B; other site 436717009041 D-loop; other site 436717009042 H-loop/switch region; other site 436717009043 putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12648 436717009044 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 436717009045 Domain related to MnhB subunit of Na+/H+ antiporter; Region: MnhB; cl00676 436717009046 Domain related to MnhB subunit of Na+/H+ antiporter; Region: MnhB; cl00676 436717009047 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492 436717009048 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12666 436717009049 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 436717009050 Na+/H+ ion antiporter subunit; Region: MNHE; cl00807 436717009051 Multiple resistance and pH regulation protein F (MrpF / PhaF); Region: MrpF_PhaF; cl09154 436717009052 Na+/H+ antiporter subunit; Region: PhaG_MnhG_YufB; cl00583 436717009053 Ribosome-binding factor A; Region: RBFA; cl00542 436717009054 translation initiation factor IF-2; Validated; Region: infB; PRK05306 436717009055 translation initiation factor IF-2; Region: IF-2; TIGR00487 436717009056 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 436717009057 IF2/eIF5B (initiation factors 2/ eukaryotic initiation factor 5B) subfamily. IF2/eIF5B contribute to ribosomal subunit joining and function as GTPases that are maximally activated by the presence of both ribosomal subunits. As seen in other GTPases...; Region: IF2_eIF5B; cd01887 436717009058 G1 box; other site 436717009059 putative GEF interaction site [polypeptide binding]; other site 436717009060 GTP/Mg2+ binding site [chemical binding]; other site 436717009061 Switch I region; other site 436717009062 G2 box; other site 436717009063 G3 box; other site 436717009064 Switch II region; other site 436717009065 G4 box; other site 436717009066 G5 box; other site 436717009067 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the...; Region: IF2_mtIF2_II; cd03702 436717009068 Translation-initiation factor 2; Region: IF-2; pfam11987 436717009069 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation...; Region: mtIF2_IVc; cd03692 436717009070 transcription elongation factor NusA; Validated; Region: nusA; PRK09202 436717009071 NusA N-terminal domain; Region: NusA_N; pfam08529 436717009072 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and...; Region: S1_NusA; cd04455 436717009073 RNA binding site [nucleotide binding]; other site 436717009074 homodimer interface [polypeptide binding]; other site 436717009075 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 436717009076 G-X-X-G motif; other site 436717009077 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 436717009078 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 436717009079 The eukaryotic Sm and Sm-like (LSm) proteins associate with RNA to form the core domain of the ribonucleoprotein particles involved in a variety of RNA processing events including pre-mRNA splicing, telomere replication, and mRNA degradation. Members...; Region: Sm_like; cl00259 436717009080 ribosome maturation protein RimP; Reviewed; Region: PRK00092 436717009081 The eukaryotic Sm and Sm-like (LSm) proteins associate with RNA to form the core domain of the ribonucleoprotein particles involved in a variety of RNA processing events including pre-mRNA splicing, telomere replication, and mRNA degradation. Members...; Region: Sm_like; cl00259 436717009082 Sm1 motif; other site 436717009083 D3 - B interaction site; other site 436717009084 D1 - D2 interaction site; other site 436717009085 Hfq - Hfq interaction site; other site 436717009086 RNA binding pocket [nucleotide binding]; other site 436717009087 Sm2 motif; other site 436717009088 potential protein location (hypothetical protein AOLE_17765 [Acinetobacter sp. DR1]) that overlaps RNA (tRNA-L and tRNAM) 436717009089 Preprotein translocase SecG subunit; Region: SecG; cl09123 436717009090 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 436717009091 substrate binding site [chemical binding]; other site 436717009092 dimer interface [polypeptide binding]; other site 436717009093 catalytic triad [active] 436717009094 type IV-A pilus assembly ATPase PilB; Region: type_IV_pilB; TIGR02538 436717009095 GSPII_E N-terminal domain; Region: GSPII_E_N; pfam05157 436717009096 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 436717009097 Walker A motif; other site 436717009098 ATP binding site [chemical binding]; other site 436717009099 Walker B motif; other site 436717009100 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 436717009101 Bacterial type II secretion system protein F domain; Region: GSPII_F; cl00906 436717009102 Bacterial type II secretion system protein F domain; Region: GSPII_F; cl00906 436717009103 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 436717009104 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 436717009105 Type IV leader peptidase family; Region: Peptidase_A24; cl02077 436717009106 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 436717009107 CoA-binding site [chemical binding]; other site 436717009108 ATP-binding [chemical binding]; other site 436717009109 EamA-like transporter family; Region: EamA; cl01037 436717009110 23S rRNA (guanosine-2'-O-)-methyltransferase; Provisional; Region: PRK11181 436717009111 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 436717009112 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 436717009113 Protein of unknown function (DUF1255); Region: DUF1255; cl01202 436717009114 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 436717009115 binding surface 436717009116 TPR motif; other site 436717009117 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 436717009118 RecN ATPase involved in DNA repair; ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds including sugars, ions, peptides...; Region: ABC_RecN; cd03241 436717009119 Walker A/P-loop; other site 436717009120 ATP binding site [chemical binding]; other site 436717009121 Q-loop/lid; other site 436717009122 RecN ATPase involved in DNA repair; ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds including sugars, ions, peptides...; Region: ABC_RecN; cd03241 436717009123 ABC transporter signature motif; other site 436717009124 Walker B; other site 436717009125 D-loop; other site 436717009126 H-loop/switch region; other site 436717009127 Uncharacterized ACR, COG1678; Region: DUF179; cl00731 436717009128 Uncharacterised protein family (UPF0081); Region: UPF0081; cl00525 436717009129 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 436717009130 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2...; Region: Biotinyl_lipoyl_domains; cl11404 436717009131 Protein of unknown function (DUF1656); Region: DUF1656; cl11658 436717009132 Bacterial protein of unknown function (DUF939); Region: DUF939; cl12136 436717009133 Fusaric acid resistance protein family; Region: FUSC; pfam04632 436717009134 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 436717009135 Transcriptional regulator [Transcription]; Region: IclR; COG1414 436717009136 Bacterial transcriptional regulator; Region: IclR; pfam01614 436717009137 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; cl01206 436717009138 bifunctional DNA-binding transcriptional dual regulator/O6-methylguanine-DNA methyltransferase; Provisional; Region: PRK15435 436717009139 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 436717009140 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 436717009141 DNA binding site [nucleotide binding] 436717009142 active site 436717009143 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 436717009144 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 436717009145 active site 436717009146 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II; cd00556 436717009147 active site 436717009148 dimer interface [polypeptide binding]; other site 436717009149 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 436717009150 GIY-YIG catalytic domain; Region: GIY-YIG; cl01061 436717009151 UvrB/uvrC motif; Region: UVR; pfam02151 436717009152 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 436717009153 Helix-hairpin-helix motif; Region: HHH_2; pfam12826 436717009154 Aspartyl/Asparaginyl beta-hydroxylase; Region: Asp_Arg_Hydrox; cl01426 436717009155 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadB; PRK11730 436717009156 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 436717009157 substrate binding site [chemical binding]; other site 436717009158 oxyanion hole (OAH) forming residues; other site 436717009159 trimer interface [polypeptide binding]; other site 436717009160 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 436717009161 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 436717009162 3-ketoacyl-CoA thiolase; Reviewed; Region: fadA; PRK08947 436717009163 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 436717009164 dimer interface [polypeptide binding]; other site 436717009165 active site 436717009166 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 436717009167 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 436717009168 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 436717009169 DNA binding residues [nucleotide binding] 436717009170 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 436717009171 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 436717009172 catalytic residues [active] 436717009173 heat shock protein 90; Provisional; Region: PRK05218 436717009174 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 436717009175 Protein of unknown function (DUF1311); Region: DUF1311; cl01530 436717009176 Surface antigen; Region: Surface_Ag_2; cl01155 436717009177 Predicted permease [General function prediction only]; Region: COG2056 436717009178 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110 436717009179 short chain dehydrogenase; Validated; Region: PRK05855 436717009180 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 436717009181 CoenzymeA binding site [chemical binding]; other site 436717009182 subunit interaction site [polypeptide binding]; other site 436717009183 PHB binding site; other site 436717009184 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 436717009185 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 436717009186 RNA polymerase Rpb1, domain 2; Region: RNA_pol_Rpb1_2; cl11591 436717009187 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 436717009188 DNA-directed RNA polymerase, beta'' subunit; Region: rpoC2_cyan; TIGR02388 436717009189 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 436717009190 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 436717009191 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 436717009192 bifunctional DNA-directed RNA polymerase subunit beta/beta'; Reviewed; Region: PRK09603 436717009193 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 436717009194 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 436717009195 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 436717009196 DNA binding site [nucleotide binding] 436717009197 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 436717009198 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl04593 436717009199 RNA polymerase beta subunit; Region: RNA_pol_Rpb2_1; cl04591 436717009200 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 436717009201 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl04593 436717009202 RPB11 interaction site [polypeptide binding]; other site 436717009203 RPB12 interaction site [polypeptide binding]; other site 436717009204 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 436717009205 RPB1 interaction site [polypeptide binding]; other site 436717009206 RPB11 interaction site [polypeptide binding]; other site 436717009207 RPB10 interaction site [polypeptide binding]; other site 436717009208 RPB3 interaction site [polypeptide binding]; other site 436717009209 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 436717009210 core dimer interface [polypeptide binding]; other site 436717009211 peripheral dimer interface [polypeptide binding]; other site 436717009212 L10 interface [polypeptide binding]; other site 436717009213 L11 interface [polypeptide binding]; other site 436717009214 putative EF-Tu interaction site [polypeptide binding]; other site 436717009215 putative EF-G interaction site [polypeptide binding]; other site 436717009216 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11...; Region: Ribosomal_L10; cd05797 436717009217 23S rRNA interface [nucleotide binding]; other site 436717009218 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 436717009219 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that...; Region: Ribosomal_L1; cd00403 436717009220 mRNA/rRNA interface [nucleotide binding]; other site 436717009221 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 436717009222 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 436717009223 23S rRNA interface [nucleotide binding]; other site 436717009224 L7/L12 interface [polypeptide binding]; other site 436717009225 putative thiostrepton binding site; other site 436717009226 L25 interface [polypeptide binding]; other site 436717009227 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 436717009228 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 436717009229 putative homodimer interface [polypeptide binding]; other site 436717009230 SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; cl00481 436717009231 elongation factor Tu; Reviewed; Region: PRK00049 436717009232 EF-Tu subfamily. This subfamily includes orthologs of translation elongation factor EF-Tu in bacteria, mitochondria, and chloroplasts. It is one of several GTP-binding translation factors found in the larger family of GTP-binding elongation factors; Region: EF_Tu; cd01884 436717009233 G1 box; other site 436717009234 GEF interaction site [polypeptide binding]; other site 436717009235 GTP/Mg2+ binding site [chemical binding]; other site 436717009236 Switch I region; other site 436717009237 G2 box; other site 436717009238 G3 box; other site 436717009239 Switch II region; other site 436717009240 G4 box; other site 436717009241 G5 box; other site 436717009242 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 436717009243 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts)...; Region: EFTU_III; cd03707 436717009244 Antibiotic Binding Site [chemical binding]; other site 436717009245 anthranilate synthase component I; Provisional; Region: PRK13565 436717009246 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 436717009247 chorismate binding enzyme; Region: Chorismate_bind; cl10555 436717009248 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 436717009249 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 436717009250 motif II; other site 436717009251 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 436717009252 phosphopeptide binding site; other site 436717009253 general secretion pathway protein D; Region: type_II_gspD; TIGR02517 436717009254 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 436717009255 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 436717009256 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 436717009257 Bacterial type II and III secretion system protein; Region: Secretin; cl02829 436717009258 general secretion pathway protein C; Region: typeII_sec_gspC; TIGR01713 436717009259 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind C-...; Region: PDZ_serine_protease; cd00987 436717009260 Bacterial type II secretion system protein N; Region: GSPII_N; pfam01203 436717009261 H-NS histone family; Region: Histone_HNS; pfam00816 436717009262 Domain in histone-like proteins of HNS family; Region: HNS; cl09251 436717009263 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active...; Region: 4HBT; cd00586 436717009264 active site 436717009265 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations...; Region: HemD; cd06578 436717009266 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 436717009267 active site 436717009268 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 436717009269 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 436717009270 domain interfaces; other site 436717009271 active site 436717009272 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 436717009273 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 436717009274 active site 436717009275 phosphorylation site [posttranslational modification] 436717009276 intermolecular recognition site; other site 436717009277 dimerization interface [polypeptide binding]; other site 436717009278 LytTr DNA-binding domain; Region: LytTR; cl04498 436717009279 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 436717009280 Histidine kinase; Region: His_kinase; pfam06580 436717009281 argininosuccinate lyase; Provisional; Region: PRK00855 436717009282 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 436717009283 active sites [active] 436717009284 tetramer interface [polypeptide binding]; other site 436717009285 Bacterial Fe(2+) trafficking; Region: Iron_traffic; cl01104 436717009286 transcriptional regulator PhoU; Provisional; Region: PRK11115 436717009287 PhoU domain; Region: PhoU; pfam01895 436717009288 PhoU domain; Region: PhoU; pfam01895 436717009289 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 436717009290 Outer membrane efflux protein; Region: OEP; pfam02321 436717009291 Outer membrane efflux protein; Region: OEP; pfam02321 436717009292 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 436717009293 EamA-like transporter family; Region: EamA; cl01037 436717009294 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 436717009295 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 436717009296 ThiC family; Region: ThiC; cl08031 436717009297 ADP-ribose pyrophosphatase NudF; Provisional; Region: nudF; PRK10729 436717009298 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as...; Region: ADPRase_NUDT5; cd03424 436717009299 dimer interface [polypeptide binding]; other site 436717009300 ADP-ribose binding site [chemical binding]; other site 436717009301 active site 436717009302 nudix motif; other site 436717009303 metal binding site [ion binding]; metal-binding site 436717009304 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 436717009305 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 436717009306 active site 436717009307 metal binding site [ion binding]; metal-binding site 436717009308 hexamer interface [polypeptide binding]; other site 436717009309 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 436717009310 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 436717009311 active site 436717009312 HIGH motif; other site 436717009313 nucleotide binding site [chemical binding]; other site 436717009314 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 436717009315 potential frameshift: common BLAST hit: gi|184156588|ref|YP_001844927.1| UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase 436717009316 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 436717009317 Ferrous iron transport protein B (FeoB) subfamily. E. coli has an iron(II) transport system, known as feo, which may make an important contribution to the iron supply of the cell under anaerobic conditions. FeoB has been identified as part of this...; Region: FeoB; cd01879 436717009318 G1 box; other site 436717009319 GTP/Mg2+ binding site [chemical binding]; other site 436717009320 Switch I region; other site 436717009321 G2 box; other site 436717009322 G3 box; other site 436717009323 Switch II region; other site 436717009324 G4 box; other site 436717009325 G5 box; other site 436717009326 Nucleoside recognition; Region: Gate; cl00486 436717009327 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 436717009328 Nucleoside recognition; Region: Gate; cl00486 436717009329 FeoA domain; Region: FeoA; cl00838 436717009330 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 436717009331 N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination of chromosomal replication, and stable plasmid...; Region: INT_XerDC; cd00798 436717009332 Int/Topo IB signature motif; other site 436717009333 active site 436717009334 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 436717009335 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide...; Region: DsbA_DsbC_DsbG; cd03020 436717009336 dimerization domain [polypeptide binding]; other site 436717009337 dimer interface [polypeptide binding]; other site 436717009338 catalytic residues [active] 436717009339 homoserine dehydrogenase; Provisional; Region: PRK06349 436717009340 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 436717009341 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 436717009342 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 436717009343 threonine synthase; Reviewed; Region: PRK06721 436717009344 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants...; Region: Thr-synth_1; cd01563 436717009345 homodimer interface [polypeptide binding]; other site 436717009346 pyridoxal 5'-phosphate binding site [chemical binding]; other site 436717009347 catalytic residue [active] 436717009348 Beta-lactamase; Region: Beta-lactamase; cl01009 436717009349 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 436717009350 response regulator; Provisional; Region: PRK09483 436717009351 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 436717009352 active site 436717009353 phosphorylation site [posttranslational modification] 436717009354 intermolecular recognition site; other site 436717009355 dimerization interface [polypeptide binding]; other site 436717009356 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 436717009357 DNA binding residues [nucleotide binding] 436717009358 dimerization interface [polypeptide binding]; other site 436717009359 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 436717009360 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cl00080 436717009361 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 436717009362 ATP binding site [chemical binding]; other site 436717009363 Mg2+ binding site [ion binding]; other site 436717009364 G-X-G motif; other site 436717009365 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 436717009366 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 436717009367 active site 436717009368 phosphorylation site [posttranslational modification] 436717009369 intermolecular recognition site; other site 436717009370 dimerization interface [polypeptide binding]; other site 436717009371 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 436717009372 Walker A motif; other site 436717009373 ATP binding site [chemical binding]; other site 436717009374 Walker B motif; other site 436717009375 arginine finger; other site 436717009376 Bacterial regulatory protein, Fis family; Region: HTH_8; cl01091 436717009377 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 436717009378 C-terminal peptidase (prc); Region: prc; TIGR00225 436717009379 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated...; Region: PDZ; cd00136 436717009380 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 436717009381 Catalytic dyad [active] 436717009382 Sulfatase; Region: Sulfatase; cl10460 436717009383 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 436717009384 Predicted permeases [General function prediction only]; Region: COG0795; cl12074 436717009385 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 436717009386 Predicted permeases [General function prediction only]; Region: COG0795; cl12074 436717009387 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 436717009388 multifunctional aminopeptidase A; Provisional; Region: PRK00913 436717009389 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein...; Region: Peptidase_M17; cd00433 436717009390 interface (dimer of trimers) [polypeptide binding]; other site 436717009391 Substrate-binding/catalytic site; other site 436717009392 Zn-binding sites [ion binding]; other site 436717009393 DNA polymerase III chi subunit, HolC; Region: DNA_pol3_chi; cl01106 436717009394 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 436717009395 Lumazine binding domain; Region: Lum_binding; pfam00677 436717009396 Lumazine binding domain; Region: Lum_binding; pfam00677 436717009397 Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG3392 436717009398 D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; cl00408 436717009399 bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase; Provisional; Region: ribD; PRK10786 436717009400 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 436717009401 catalytic motif [active] 436717009402 Zn binding site [ion binding]; other site 436717009403 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5,10-...; Region: DHFR; cl00161 436717009404 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 436717009405 ATP cone domain; Region: ATP-cone; pfam03477 436717009406 Ammonium Transporter Family; Region: Ammonium_transp; cl03012 436717009407 Nitrogen regulatory protein P-II; Region: P-II; cl00412 436717009408 Membrane fusogenic activity; Region: BMFP; cl01115 436717009409 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 436717009410 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 436717009411 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 436717009412 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 436717009413 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 436717009414 DNA-binding site [nucleotide binding]; DNA binding site 436717009415 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 436717009416 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 436717009417 pyridoxal 5'-phosphate binding site [chemical binding]; other site 436717009418 homodimer interface [polypeptide binding]; other site 436717009419 catalytic residue [active] 436717009420 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II)...; Region: Aldolase_II; cl00214 436717009421 intersubunit interface [polypeptide binding]; other site 436717009422 active site 436717009423 Zn2+ binding site [ion binding]; other site 436717009424 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 436717009425 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 436717009426 inhibitor site; inhibition site 436717009427 active site 436717009428 dimer interface [polypeptide binding]; other site 436717009429 catalytic residue [active] 436717009430 Bacterial protein of unknown function (Gcw_chp); Region: Gcw_chp; cl09901 436717009431 outer membrane porin, OprD family; Region: OprD; pfam03573 436717009432 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 436717009433 dimer interface [polypeptide binding]; other site 436717009434 substrate binding site [chemical binding]; other site 436717009435 metal binding sites [ion binding]; metal-binding site 436717009436 MAPEG family; Region: MAPEG; cl09190 436717009437 Long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07059 436717009438 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 436717009439 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 436717009440 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in...; Region: TOP4c; cd00187 436717009441 CAP-like domain; other site 436717009442 Active site [active] 436717009443 primary dimer interface [polypeptide binding]; other site 436717009444 benzoate transport; Region: 2A0115; TIGR00895 436717009445 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 436717009446 putative substrate translocation pore; other site 436717009447 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 436717009448 Predicted membrane protein [Function unknown]; Region: COG2860 436717009449 UPF0126 domain; Region: UPF0126; pfam03458 436717009450 UPF0126 domain; Region: UPF0126; pfam03458 436717009451 hypothetical protein; Provisional; Region: PRK01752 436717009452 SEC-C motif; Region: SEC-C; cl12132 436717009453 SEC-C motif; Region: SEC-C; cl12132 436717009454 Integral membrane protein TerC family; Region: TerC; cl10468 436717009455 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 436717009456 Transporter associated domain; Region: CorC_HlyC; pfam03471 436717009457 DNA recombination-mediator protein A; Region: DNA_processg_A; cl00695 436717009458 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 436717009459 putative transporter; Provisional; Region: PRK10504 436717009460 putative substrate translocation pore; other site 436717009461 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 436717009462 Uncharacterized bacterial muramidase containing a glycosyl hydrolase family 25 (GH25) catalytic domain. Endo-N-acetylmuramidases are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the...; Region: GH25_muramidase_1; cd06413 436717009463 active site 436717009464 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 436717009465 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 436717009466 active site 436717009467 DNA polymerase IV; Validated; Region: PRK02406 436717009468 DNA binding site [nucleotide binding] 436717009469 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150 436717009470 homotrimer interaction site [polypeptide binding]; other site 436717009471 putative active site [active] 436717009472 Protein of unknown function (DUF2726); Region: DUF2726; pfam10881 436717009473 hypothetical protein; Provisional; Region: PRK01254 436717009474 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cl14056 436717009475 Domain of unknown function (DUF3362); Region: DUF3362; pfam11842 436717009476 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4222 436717009477 Cu(I)-responsive transcriptional regulator; Region: CueR; TIGR02044 436717009478 Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg6; cd04781 436717009479 DNA binding residues [nucleotide binding] 436717009480 putative dimer interface [polypeptide binding]; other site 436717009481 putative metal binding residues [ion binding]; other site 436717009482 Protein of unknown function (DUF2938); Region: DUF2938; pfam11158 436717009483 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 436717009484 Protein of unknown function (DUF2798); Region: DUF2798; pfam11391 436717009485 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 436717009486 N-acetyl-D-glucosamine binding site [chemical binding]; other site 436717009487 catalytic residue [active] 436717009488 cysteine synthases; Region: cysKM; TIGR01136 436717009489 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine...; Region: CBS_like; cd01561 436717009490 dimer interface [polypeptide binding]; other site 436717009491 pyridoxal 5'-phosphate binding site [chemical binding]; other site 436717009492 catalytic residue [active] 436717009493 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 436717009494 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 436717009495 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 436717009496 TonB-dependent copper receptor; Region: TonB-copper; TIGR01778 436717009497 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 436717009498 N-terminal plug; other site 436717009499 ligand-binding site [chemical binding]; other site 436717009500 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(...; Region: Pep_deformylase; cd00487 436717009501 active site 436717009502 catalytic residues [active] 436717009503 metal binding site [ion binding]; metal-binding site 436717009504 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cl00107 436717009505 DNA recombination-mediator protein A; Region: DNA_processg_A; cl00695 436717009506 yrdC domain; Region: Sua5_yciO_yrdC; cl00305 436717009507 EamA-like transporter family; Region: EamA; cl01037 436717009508 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 436717009509 EamA-like transporter family; Region: EamA; cl01037 436717009510 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 436717009511 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 436717009512 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 436717009513 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 436717009514 putative substrate translocation pore; other site 436717009515 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 436717009516 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 436717009517 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue...; Region: GSH_Peroxidase; cd00340 436717009518 catalytic residues [active] 436717009519 dimer interface [polypeptide binding]; other site 436717009520 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 436717009521 ATP synthase, Delta/Epsilon chain, beta-sandwich domain; Region: ATP-synt_DE_N; cl10033 436717009522 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 436717009523 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 436717009524 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 436717009525 alpha subunit interaction interface [polypeptide binding]; other site 436717009526 Walker A motif; other site 436717009527 ATP binding site [chemical binding]; other site 436717009528 Walker B motif; other site 436717009529 inhibitor binding site; inhibition site 436717009530 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 436717009531 ATP synthase; Region: ATP-synt; cl00365 436717009532 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 436717009533 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 436717009534 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 436717009535 Walker A motif; other site 436717009536 ATP binding site [chemical binding]; other site 436717009537 Walker B motif; other site 436717009538 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 436717009539 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl07975 436717009540 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 436717009541 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl07975 436717009542 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 436717009543 ATP synthase subunit C; Region: ATP-synt_C; cl00466 436717009544 ATP synthase A chain; Region: ATP-synt_A; cl00413 436717009545 ATP synthase I chain; Region: ATP_synt_I; cl09170 436717009546 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface...; Region: TroA-like; cl00262 436717009547 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 436717009548 intersubunit interface [polypeptide binding]; other site 436717009549 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 436717009550 metal binding site 2 [ion binding]; metal-binding site 436717009551 putative DNA binding helix; other site 436717009552 metal binding site 1 [ion binding]; metal-binding site 436717009553 dimer interface [polypeptide binding]; other site 436717009554 structural Zn2+ binding site [ion binding]; other site 436717009555 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 436717009556 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 436717009557 Walker A/P-loop; other site 436717009558 ATP binding site [chemical binding]; other site 436717009559 Q-loop/lid; other site 436717009560 ABC transporter signature motif; other site 436717009561 Walker B; other site 436717009562 D-loop; other site 436717009563 H-loop/switch region; other site 436717009564 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist...; Region: TM_ABC_iron-siderophores_like; cd06550 436717009565 ABC-ATPase subunit interface; other site 436717009566 dimer interface [polypeptide binding]; other site 436717009567 putative PBP binding regions; other site 436717009568 LysE type translocator; Region: LysE; cl00565 436717009569 Dyp-type peroxidase family; Region: Dyp_perox; cl01067 436717009570 malate dehydrogenase; Provisional; Region: PRK13529 436717009571 Malic enzyme, N-terminal domain; Region: malic; pfam00390 436717009572 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 436717009573 NAD(P) binding site [chemical binding]; other site 436717009574 Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; pfam03485 436717009575 Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018 436717009576 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 436717009577 active site 436717009578 HIGH motif; other site 436717009579 nucleotide binding site [chemical binding]; other site 436717009580 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 436717009581 KMSK motif region; other site 436717009582 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 436717009583 tRNA binding surface [nucleotide binding]; other site 436717009584 anticodon binding site; other site 436717009585 Sporulation related domain; Region: SPOR; cl10051 436717009586 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 436717009587 GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins...; Region: GST_N_GTT1_like; cd03046 436717009588 putative C-terminal domain interface [polypeptide binding]; other site 436717009589 putative GSH binding site (G-site) [chemical binding]; other site 436717009590 putative dimer interface [polypeptide binding]; other site 436717009591 GST_C family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins...; Region: GST_C_GTT1_like; cd03189 436717009592 putative N-terminal domain interface [polypeptide binding]; other site 436717009593 putative dimer interface [polypeptide binding]; other site 436717009594 putative substrate binding pocket (H-site) [chemical binding]; other site 436717009595 OsmC-like protein; Region: OsmC; cl00767 436717009596 Pirin-related protein [General function prediction only]; Region: COG1741 436717009597 Cupin domain; Region: Cupin_2; cl09118 436717009598 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 436717009599 Domain of Unknown Function with PDB structure; Region: DUF3861; pfam12977 436717009600 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 436717009601 putative DNA binding helix; other site 436717009602 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 436717009603 GMP synthase; Reviewed; Region: guaA; PRK00074 436717009604 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 436717009605 AMP/PPi binding site [chemical binding]; other site 436717009606 candidate oxyanion hole; other site 436717009607 catalytic triad [active] 436717009608 potential glutamine specificity residues [chemical binding]; other site 436717009609 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 436717009610 ATP Binding subdomain [chemical binding]; other site 436717009611 Ligand Binding sites [chemical binding]; other site 436717009612 Dimerization subdomain; other site 436717009613 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399 436717009614 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399 436717009615 DoxX; Region: DoxX; cl00976 436717009616 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 436717009617 LysE type translocator; Region: LysE; cl00565 436717009618 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 436717009619 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following...; Region: ParA; cd02042 436717009620 P-loop; other site 436717009621 Magnesium ion binding site [ion binding]; other site 436717009622 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following...; Region: ParA; cd02042 436717009623 Magnesium ion binding site [ion binding]; other site 436717009624 Invasion gene expression up-regulator, SirB; Region: SirB; cl01184 436717009625 BolA-like protein; Region: BolA; cl00386 436717009626 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 436717009627 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500 436717009628 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 436717009629 NAD(P) binding site [chemical binding]; other site 436717009630 active site 436717009631 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 436717009632 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 436717009633 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 436717009634 hydrophobic ligand binding site; other site 436717009635 Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033 436717009636 Protein of unknown function (DUF1329); Region: DUF1329; pfam07044 436717009637 peptide synthase; Provisional; Region: PRK12467 436717009638 Condensation domain; Region: Condensation; cl09290 436717009639 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 436717009640 Phosphopantetheine attachment site; Region: PP-binding; cl09936 436717009641 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 436717009642 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 436717009643 Phosphopantetheine attachment site; Region: PP-binding; cl09936 436717009644 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 436717009645 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 436717009646 active site 436717009647 peptide synthase; Validated; Region: PRK05691 436717009648 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 436717009649 DNA-binding transcriptional activator SdiA; Provisional; Region: PRK10188 436717009650 Autoinducer binding domain; Region: Autoind_bind; pfam03472 436717009651 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 436717009652 DNA binding residues [nucleotide binding] 436717009653 dimerization interface [polypeptide binding]; other site 436717009654 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 436717009655 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 436717009656 metabolite-proton symporter; Region: 2A0106; TIGR00883 436717009657 putative substrate translocation pore; other site 436717009658 3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617 436717009659 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 436717009660 substrate binding site [chemical binding]; other site 436717009661 oxyanion hole (OAH) forming residues; other site 436717009662 trimer interface [polypeptide binding]; other site 436717009663 enoyl-CoA hydratase; Provisional; Region: PRK05862 436717009664 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 436717009665 substrate binding site [chemical binding]; other site 436717009666 oxyanion hole (OAH) forming residues; other site 436717009667 trimer interface [polypeptide binding]; other site 436717009668 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 436717009669 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 436717009670 active site 436717009671 acetyl-CoA synthetase; Provisional; Region: PRK04319 436717009672 Domain of unknown function (DUF3448); Region: DUF3448; pfam11930 436717009673 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 436717009674 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 436717009675 3-hydroxyisobutyrate dehydrogenase; Region: HIBADH; TIGR01692 436717009676 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 436717009677 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 436717009678 tetrameric interface [polypeptide binding]; other site 436717009679 NAD binding site [chemical binding]; other site 436717009680 catalytic residues [active] 436717009681 Transcriptional regulator [Transcription]; Region: LysR; COG0583 436717009682 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 436717009683 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 436717009684 dimerization interface [polypeptide binding]; other site 436717009685 Transmembrane amino acid transporter protein; Region: Aa_trans; cl00524 436717009686 Amino acid permease; Region: AA_permease; pfam00324 436717009687 Transmembrane amino acid transporter protein; Region: Aa_trans; cl00524 436717009688 Amino acid permease; Region: AA_permease; pfam00324 436717009689 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150 436717009690 homotrimer interaction site [polypeptide binding]; other site 436717009691 putative active site [active] 436717009692 alanine racemase; Reviewed; Region: dadX; PRK03646 436717009693 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827 436717009694 active site 436717009695 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 436717009696 substrate binding site [chemical binding]; other site 436717009697 catalytic residues [active] 436717009698 dimer interface [polypeptide binding]; other site 436717009699 Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl14881 436717009700 D-amino acid dehydrogenase small subunit; Provisional; Region: PRK12409 436717009701 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 436717009702 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 436717009703 Protein of unknown function (DUF1624); Region: DUF1624; cl01394 436717009704 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 436717009705 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 436717009706 N-terminal plug; other site 436717009707 ligand-binding site [chemical binding]; other site 436717009708 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 436717009709 Protein of unknown function (DUF1260); Region: DUF1260; cl01170 436717009710 PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF...; Region: PseudoU_synth_RluCD_like; cd02869 436717009711 active site 436717009712 Protein of unknown function (DUF1003); Region: DUF1003; cl01831 436717009713 Protein of unknown function (DUF2867); Region: DUF2867; pfam11066 436717009714 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 436717009715 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 436717009716 putative substrate translocation pore; other site 436717009717 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 436717009718 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 436717009719 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 436717009720 NAD(P) binding site [chemical binding]; other site 436717009721 active site 436717009722 Uncharacterized protein conserved in bacteria [Function unknown]; Region: VgrG; COG3501 436717009723 Phage-related baseplate assembly protein; Region: Phage_base_V; cl11432 436717009724 Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; cl01733 436717009725 Sel1 repeat; Region: Sel1; cl02723 436717009726 Sel1 repeat; Region: Sel1; cl02723 436717009727 Sel1 repeat; Region: Sel1; cl02723 436717009728 Sel1 repeat; Region: Sel1; cl02723 436717009729 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 436717009730 hypothetical protein; Provisional; Region: PRK11032 436717009731 2-methylisocitrate dehydratase, Fe/S-dependent; Region: 2met_isocit_dHY; TIGR02333 436717009732 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 436717009733 substrate binding site [chemical binding]; other site 436717009734 ligand binding site [chemical binding]; other site 436717009735 Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215 436717009736 substrate binding site [chemical binding]; other site 436717009737 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 436717009738 Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A (...; Region: CS_ACL-C_CCL; cl00416 436717009739 oxalacetate binding site [chemical binding]; other site 436717009740 citrylCoA binding site [chemical binding]; other site 436717009741 coenzyme A binding site [chemical binding]; other site 436717009742 catalytic triad [active] 436717009743 PEP phosphonomutase and related enzymes [Carbohydrate transport and metabolism]; Region: PrpB; COG2513 436717009744 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 436717009745 tetramer interface [polypeptide binding]; other site 436717009746 active site 436717009747 Mg2+/Mn2+ binding site [ion binding]; other site 436717009748 Transcriptional regulators [Transcription]; Region: GntR; COG1802 436717009749 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 436717009750 DNA-binding site [nucleotide binding]; DNA binding site 436717009751 FCD domain; Region: FCD; cl11656 436717009752 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 436717009753 pyridoxal 5'-phosphate binding site [chemical binding]; other site 436717009754 homodimer interface [polypeptide binding]; other site 436717009755 catalytic residue [active] 436717009756 D-lactate dehydrogenase; Provisional; Region: PRK11183 436717009757 FAD binding domain; Region: FAD_binding_4; pfam01565 436717009758 D-lactate dehydrogenase, membrane binding; Region: Lact-deh-memb; pfam09330 436717009759 L-lactate dehydrogenase; Provisional; Region: lldD; PRK11197 436717009760 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 436717009761 phosphate binding site [ion binding]; other site 436717009762 DNA-binding transcriptional repressor LldR; Provisional; Region: PRK10421 436717009763 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 436717009764 DNA-binding site [nucleotide binding]; DNA binding site 436717009765 FCD domain; Region: FCD; cl11656 436717009766 L-lactate permease; Region: Lactate_perm; cl00701 436717009767 glycolate transporter; Provisional; Region: PRK09695 436717009768 phosphomannomutase CpsG; Provisional; Region: PRK15414 436717009769 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 436717009770 active site 436717009771 substrate binding site [chemical binding]; other site 436717009772 metal binding site [ion binding]; metal-binding site 436717009773 Sulfatase; Region: Sulfatase; cl10460 436717009774 Acyltransferase family; Region: Acyl_transf_3; pfam01757 436717009775 Predicted O-acyltransferase [General function prediction only]; Region: COG3274; cl00792 436717009776 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 436717009777 UDP-glucose 4-epimerase; Region: PLN02240 436717009778 NAD binding site [chemical binding]; other site 436717009779 homodimer interface [polypeptide binding]; other site 436717009780 active site 436717009781 substrate binding site [chemical binding]; other site 436717009782 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 436717009783 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 436717009784 active site 436717009785 dimer interface [polypeptide binding]; other site 436717009786 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 436717009787 dimer interface [polypeptide binding]; other site 436717009788 active site 436717009789 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 436717009790 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 436717009791 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 436717009792 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 436717009793 active site 436717009794 tetramer interface [polypeptide binding]; other site 436717009795 Bacterial sugar transferase; Region: Bac_transf; cl00939 436717009796 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 436717009797 active site 436717009798 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 436717009799 UDP-N-acetylglucosamine 2-epimerase; Region: wecB; TIGR00236 436717009800 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues...; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 436717009801 active site 436717009802 homodimer interface [polypeptide binding]; other site 436717009803 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 436717009804 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 436717009805 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 436717009806 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the 6-...; Region: LbH_MAT_like; cd04647 436717009807 trimer interface [polypeptide binding]; other site 436717009808 active site 436717009809 substrate binding site [chemical binding]; other site 436717009810 CoA binding site [chemical binding]; other site 436717009811 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 436717009812 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 436717009813 inhibitor-cofactor binding pocket; inhibition site 436717009814 pyridoxal 5'-phosphate binding site [chemical binding]; other site 436717009815 catalytic residue [active] 436717009816 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 436717009817 WcxM-like, Left-handed parallel beta-Helix (LbH) N-terminal domain: This group is composed of Xanthomonas campestris WcxM and proteins with similarity to the WcxM N-terminal domain. WcxM is thought to be bifunctional, catalyzing both the isomerization...; Region: LbH_WxcM_N_like; cd03358 436717009818 putative trimer interface [polypeptide binding]; other site 436717009819 putative active site [active] 436717009820 putative substrate binding site [chemical binding]; other site 436717009821 putative CoA binding site [chemical binding]; other site 436717009822 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 436717009823 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 436717009824 Vi polysaccharide biosynthesis protein TviB; Provisional; Region: PRK15182 436717009825 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 436717009826 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 436717009827 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 436717009828 polysaccharide export protein Wza; Provisional; Region: PRK15078 436717009829 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 436717009830 Low molecular weight phosphatase family; Region: LMWPc; cd00115 436717009831 Active site [active] 436717009832 tyrosine kinase; Provisional; Region: PRK11519 436717009833 Chain length determinant protein; Region: Wzz; cl01623 436717009834 Chain length determinant protein; Region: Wzz; cl01623 436717009835 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 436717009836 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 436717009837 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 436717009838 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587 436717009839 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 436717009840 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 436717009841 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587 436717009842 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 436717009843 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 436717009844 amidase catalytic site [active] 436717009845 Zn binding residues [ion binding]; other site 436717009846 substrate binding site [chemical binding]; other site 436717009847 quinolinate phosphoribosyltransferase; Validated; Region: PRK09016 436717009848 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with 5-...; Region: QPRTase; cd01572 436717009849 dimerization interface [polypeptide binding]; other site 436717009850 active site 436717009851 Pseudomonas-type; Region: PC_PLC; TIGR03396 436717009852 Phosphoesterase family; Region: Phosphoesterase; cl10627 436717009853 Domain of unknown function (DUF756); Region: DUF756; pfam05506 436717009854 Domain of unknown function (DUF756); Region: DUF756; pfam05506 436717009855 ribonuclease PH; Reviewed; Region: rph; PRK00173 436717009856 3' exoribonuclease family, domain 1; Region: RNase_PH; pfam01138 436717009857 3' exoribonuclease family, domain 2; Region: RNase_PH_C; pfam03725 436717009858 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 436717009859 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These...; Region: Delta6-FADS-like; cd03506 436717009860 putative di-iron ligands [ion binding]; other site 436717009861 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_2; cd06216 436717009862 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 436717009863 FAD binding pocket [chemical binding]; other site 436717009864 FAD binding motif [chemical binding]; other site 436717009865 phosphate binding motif [ion binding]; other site 436717009866 beta-alpha-beta structure motif; other site 436717009867 NAD binding pocket [chemical binding]; other site 436717009868 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 436717009869 catalytic loop [active] 436717009870 iron binding site [ion binding]; other site 436717009871 DNA-binding transcriptional repressor FabR; Provisional; Region: PRK11202 436717009872 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 436717009873 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 436717009874 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 436717009875 DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019 436717009876 catalytic residues [active] 436717009877 hinge region; other site 436717009878 alpha helical domain; other site 436717009879 bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134 436717009880 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 436717009881 S-adenosylmethionine binding site [chemical binding]; other site 436717009882 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 436717009883 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 436717009884 active site 436717009885 motif I; other site 436717009886 motif II; other site 436717009887 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 436717009888 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 436717009889 NAD(P) binding site [chemical binding]; other site 436717009890 active site 436717009891 Domain of unknown function (DUF3315); Region: DUF3315; cl02275 436717009892 Domain of unknown function (DUF3315); Region: DUF3315; cl02275 436717009893 N-acetylglutamate synthase; Validated; Region: PRK05279 436717009894 AAK_NAGS-ABP: N-acetylglutamate (NAG) kinase-like domain of the NAG Synthase (NAGS) of the arginine-biosynthesis pathway (ABP) found in gamma- and beta-proteobacteria and higher plant chloroplasts. Domain architecture of these NAGS consisted of an N-...; Region: AAK_NAGS-ABP; cd04237 436717009895 putative feedback inhibition sensing region; other site 436717009896 putative nucleotide binding site [chemical binding]; other site 436717009897 putative substrate binding site [chemical binding]; other site 436717009898 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 436717009899 Coenzyme A binding pocket [chemical binding]; other site 436717009900 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 436717009901 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and...; Region: PBPb; cd00134 436717009902 substrate binding pocket [chemical binding]; other site 436717009903 membrane-bound complex binding site; other site 436717009904 hinge residues; other site 436717009905 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 436717009906 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and...; Region: PBPb; cd00134 436717009907 substrate binding pocket [chemical binding]; other site 436717009908 membrane-bound complex binding site; other site 436717009909 hinge residues; other site 436717009910 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 436717009911 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 436717009912 active site 436717009913 dimer interface [polypeptide binding]; other site 436717009914 non-prolyl cis peptide bond; other site 436717009915 insertion regions; other site 436717009916 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 436717009917 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 436717009918 putative PBP binding loops; other site 436717009919 dimer interface [polypeptide binding]; other site 436717009920 ABC-ATPase subunit interface; other site 436717009921 aliphatic sulfonates transport ATP-binding subunit; Provisional; Region: ssuB; PRK11247 436717009922 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars...; Region: ABC_NrtD_SsuB_transporters; cd03293 436717009923 Walker A/P-loop; other site 436717009924 ATP binding site [chemical binding]; other site 436717009925 Q-loop/lid; other site 436717009926 ABC transporter signature motif; other site 436717009927 Walker B; other site 436717009928 D-loop; other site 436717009929 H-loop/switch region; other site 436717009930 pyrimidine utilization regulatory protein R; Region: RutR; TIGR03613 436717009931 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 436717009932 YcdC-like protein, C-terminal region; Region: TetR_C_3; pfam08362 436717009933 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 436717009934 Tellurite-resistance/Dicarboxylate Transporter (TDT) family includes sulfite sensitivity protein (sulfite efflux pump; SSU1); Region: TDT_SSU1; cd09318 436717009935 gating phenylalanine in ion channel; other site 436717009936 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 436717009937 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 436717009938 active site 436717009939 Riboflavin kinase; Region: Flavokinase; pfam01687 436717009940 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 436717009941 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 436717009942 active site 436717009943 HIGH motif; other site 436717009944 nucleotide binding site [chemical binding]; other site 436717009945 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 436717009946 active site 436717009947 KMSKS motif; other site 436717009948 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 436717009949 tRNA binding surface [nucleotide binding]; other site 436717009950 anticodon binding site; other site 436717009951 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 436717009952 Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458 436717009953 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587 436717009954 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 436717009955 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 436717009956 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 436717009957 substrate binding site [chemical binding]; other site 436717009958 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 436717009959 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 436717009960 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 436717009961 Transcriptional regulator [Transcription]; Region: LysR; COG0583 436717009962 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 436717009963 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 436717009964 putative effector binding pocket; other site 436717009965 dimerization interface [polypeptide binding]; other site 436717009966 Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576 436717009967 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding...; Region: GrpE; cd00446 436717009968 dimer interface [polypeptide binding]; other site 436717009969 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 436717009970 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 436717009971 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families...; Region: ZnMc; cl00064 436717009972 active site 436717009973 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 436717009974 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families...; Region: ZnMc; cl00064 436717009975 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families...; Region: ZnMc; cl00064 436717009976 active site 436717009977 active site 436717009978 lytic murein transglycosylase; Region: MltB_2; TIGR02283 436717009979 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases...; Region: lysozyme_like; cl00222 436717009980 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 436717009981 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 436717009982 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 436717009983 AIR carboxylase; Region: AIRC; cl00310 436717009984 Protein of unknown function, DUF486; Region: DUF486; cl01236 436717009985 UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase; Region: mpl; TIGR01081 436717009986 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 436717009987 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 436717009988 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 436717009989 Bacterial low temperature requirement A protein (LtrA); Region: LtrA; cl01754 436717009990 PAP2_like proteins, BcrC_like subfamily. Several members of this family have been annotated as bacitracin transport permeases, as it was suspected that they form the permease component of an ABC transporter system. It was shown, however, that BcrC from...; Region: PAP2_BcrC_like; cd03385 436717009991 active site 436717009992 Integral membrane protein TerC family; Region: TerC; cl10468 436717009993 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 436717009994 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 436717009995 [2Fe-2S] cluster binding site [ion binding]; other site 436717009996 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 436717009997 hydrophobic ligand binding site; other site 436717009998 guanine deaminase; Provisional; Region: PRK09228 436717009999 Guanine deaminase (GDEase). Guanine deaminase is an aminohydrolase responsible for the conversion of guanine to xanthine and ammonia, the first step to utilize guanine as a nitrogen source. This reaction also removes the guanine base from the pool and...; Region: GDEase; cd01303 436717010000 active site 436717010001 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 436717010002 Transglycosylase associated protein; Region: Transgly_assoc; cl00978 436717010003 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 436717010004 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide...; Region: DsbA_DsbC_DsbG; cd03020 436717010005 dimerization domain [polypeptide binding]; other site 436717010006 dimer interface [polypeptide binding]; other site 436717010007 catalytic residues [active] 436717010008 Cation efflux family; Region: Cation_efflux; cl00316 436717010009 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 436717010010 Transcriptional regulators RcnR and FrmR, and related domains; this domain family was previously known as part of DUF156; Region: RcnR-FrmR-like_DUF156; cd10153 436717010011 putative metal binding site [ion binding]; other site 436717010012 putative homotetramer interface [polypeptide binding]; other site 436717010013 putative homodimer interface [polypeptide binding]; other site 436717010014 putative homodimer-homodimer interface [polypeptide binding]; other site 436717010015 putative allosteric switch controlling residues; other site 436717010016 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 436717010017 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 436717010018 TrmE (MnmE, ThdF, MSS1) is a 3-domain protein found in bacteria and eukaryotes. It controls modification of the uridine at the wobble position (U34) of tRNAs that read codons ending with A or G in the mixed codon family boxes. TrmE contains a GTPase...; Region: trmE; cd04164 436717010019 G1 box; other site 436717010020 GTP/Mg2+ binding site [chemical binding]; other site 436717010021 Switch I region; other site 436717010022 G2 box; other site 436717010023 Switch II region; other site 436717010024 G3 box; other site 436717010025 G4 box; other site 436717010026 G5 box; other site 436717010027 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 436717010028 membrane protein insertase; Provisional; Region: PRK01318 436717010029 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 436717010030 Domain of unknown function DUF37; Region: DUF37; cl00506 436717010031 Ribonuclease P; Region: Ribonuclease_P; cl00457 436717010032 Ribosomal protein L34; Region: Ribosomal_L34; cl00370