-- dump date   	20140618_190058
-- class       	Genbank::misc_feature
-- table       	misc_feature_note
-- id	note
405416000001	Initiator Replication protein; Region: Rep_3; pfam01051
405416000002	Helix-turn-helix domain; Region: HTH_17; cl17695
405416000003	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316
405416000004	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
405416000005	Integrase core domain; Region: rve; pfam00665
405416000006	Domain of unknown function (DUF3387); Region: DUF3387; pfam11867
405416000007	Initiator Replication protein; Region: Rep_3; pfam01051
405416000008	ParA-like protein; Provisional; Region: PHA02518
405416000009	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
405416000010	P-loop; other site
405416000011	Magnesium ion binding site [ion binding]; other site
405416000012	Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: StbD; COG2161
405416000013	Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026
405416000014	putative transposase OrfB; Reviewed; Region: PHA02517
405416000015	HTH-like domain; Region: HTH_21; pfam13276
405416000016	Integrase core domain; Region: rve; pfam00665
405416000017	Integrase core domain; Region: rve_3; pfam13683
405416000018	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
405416000019	multiple promoter invertase; Provisional; Region: mpi; PRK13413
405416000020	catalytic residues [active]
405416000021	catalytic nucleophile [active]
405416000022	Presynaptic Site I dimer interface [polypeptide binding]; other site
405416000023	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
405416000024	Synaptic Flat tetramer interface [polypeptide binding]; other site
405416000025	Synaptic Site I dimer interface [polypeptide binding]; other site
405416000026	DNA binding site [nucleotide binding]
405416000027	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
405416000028	DNA-binding interface [nucleotide binding]; DNA binding site
405416000029	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
405416000030	Sel1-like repeats; Region: SEL1; smart00671
405416000031	putative transposase OrfB; Reviewed; Region: PHA02517
405416000032	HTH-like domain; Region: HTH_21; pfam13276
405416000033	Integrase core domain; Region: rve; pfam00665
405416000034	Integrase core domain; Region: rve_3; pfam13683
405416000035	Beta-lactamase class D [Defense mechanisms]; Region: COG2602
405416000036	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677
405416000037	InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811
405416000038	InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759
405416000039	IS1 transposase; Region: DDE_Tnp_IS1; cl00721
405416000040	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
405416000041	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316
405416000042	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
405416000043	Integrase core domain; Region: rve; pfam00665
405416000044	putative transposase OrfB; Reviewed; Region: PHA02517
405416000045	HTH-like domain; Region: HTH_21; pfam13276
405416000046	Integrase core domain; Region: rve; pfam00665
405416000047	Integrase core domain; Region: rve_3; pfam13683
405416000048	Beta-lactamase class D [Defense mechanisms]; Region: COG2602
405416000049	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677
405416000050	InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811
405416000051	InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759
405416000052	IS1 transposase; Region: DDE_Tnp_IS1; cl00721
405416000053	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
405416000054	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316
405416000055	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
405416000056	Integrase core domain; Region: rve; pfam00665
405416000057	TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029
405416000058	active site
405416000059	metal binding site [ion binding]; metal-binding site
405416000060	interdomain interaction site; other site
405416000061	DEAD-like helicases superfamily; Region: DEXDc; smart00487
405416000062	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
405416000063	ATP binding site [chemical binding]; other site
405416000064	putative Mg++ binding site [ion binding]; other site
405416000065	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351
405416000066	nucleotide binding region [chemical binding]; other site
405416000067	ATP-binding site [chemical binding]; other site
405416000068	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
405416000069	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
405416000070	non-specific DNA binding site [nucleotide binding]; other site
405416000071	salt bridge; other site
405416000072	sequence-specific DNA binding site [nucleotide binding]; other site
405416000073	RT_Bac_retron_II: Reverse transcriptases (RTs) in bacterial retrotransposons or retrons. The polymerase reaction of this enzyme leads to the production of a unique RNA-DNA complex called msDNA (multicopy single-stranded (ss)DNA) in which a small ssDNA...; Region: RT_Bac_retron_II; cd03487
405416000074	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
405416000075	putative active site [active]
405416000076	putative NTP binding site [chemical binding]; other site
405416000077	putative nucleic acid binding site [nucleotide binding]; other site
405416000078	Replicase family; Region: Replicase; pfam03090
405416000079	Primase C terminal 1 (PriCT-1); Region: PriCT_1; pfam08708
405416000080	Homeodomain-like domain; Region: HTH_23; pfam13384
405416000081	Zeta toxin; Region: Zeta_toxin; pfam06414
405416000082	Protein of unknown function (DUF1173); Region: DUF1173; pfam06666
405416000083	Staphylococcal nuclease homologues; Region: SNc; smart00318
405416000084	Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cd00175
405416000085	Catalytic site; other site
405416000086	H-NS histone family; Region: Histone_HNS; pfam00816
405416000087	Domain in histone-like proteins of HNS family; Region: HNS; smart00528
405416000088	Protein of unknown function (DUF2786); Region: DUF2786; pfam10979
405416000089	Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286
405416000090	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
405416000091	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
405416000092	P-loop; other site
405416000093	Magnesium ion binding site [ion binding]; other site
405416000094	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
405416000095	Magnesium ion binding site [ion binding]; other site
405416000096	ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180
405416000097	ParB-like nuclease domain; Region: ParB; smart00470
405416000098	KorB domain; Region: KorB; pfam08535
405416000099	Toxic anion resistance protein (TelA); Region: TelA; pfam05816
405416000100	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cl02542
405416000101	HSP70 interaction site [polypeptide binding]; other site
405416000102	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
405416000103	Type IV secretion-system coupling protein DNA-binding domain; Region: TrwB_AAD_bind; pfam10412
405416000104	Walker A motif; other site
405416000105	ATP binding site [chemical binding]; other site
405416000106	Walker B motif; other site
405416000107	TrwC relaxase; Region: TrwC; pfam08751
405416000108	conjugative relaxase domain, TrwC/TraI family; Region: relax_trwC; TIGR02686
405416000109	AAA domain; Region: AAA_30; pfam13604
405416000110	Family description; Region: UvrD_C_2; pfam13538
405416000111	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
405416000112	Helix-turn-helix domain; Region: HTH_38; pfam13936
405416000113	Homeodomain-like domain; Region: HTH_32; pfam13565
405416000114	Integrase core domain; Region: rve; pfam00665
405416000115	Integrase core domain; Region: rve_3; cl15866
405416000116	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788
405416000117	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
405416000118	catalytic residues [active]
405416000119	catalytic nucleophile [active]
405416000120	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
405416000121	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
405416000122	N-acetyl-D-glucosamine binding site [chemical binding]; other site
405416000123	catalytic residue [active]
405416000124	TraL protein; Region: TraL; cl06278
405416000125	TraE protein; Region: TraE; cl05060
405416000126	TraK protein; Region: TraK; pfam06586
405416000127	conjugal transfer protein TraK; Provisional; Region: PRK13736; cl05878
405416000128	Protein of unknown function (DUF1510); Region: DUF1510; pfam07423
405416000129	Bacterial conjugation TrbI-like protein; Region: TrbI; pfam03743
405416000130	DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020
405416000131	dimerization domain [polypeptide binding]; other site
405416000132	dimer interface [polypeptide binding]; other site
405416000133	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
405416000134	catalytic residues [active]
405416000135	type IV conjugative transfer system lipoprotein TraV; Region: TraV; TIGR02747
405416000136	Type IV conjugative transfer system lipoprotein (TraV); Region: TraV; pfam09676
405416000137	type-IV secretion system protein TraC; Region: TraC-F-type; TIGR02746
405416000138	F pilus assembly Type-IV secretion system for plasmid transfer; Region: TraC_F_IV; pfam11130
405416000139	Sex factor F TraW protein N terminal; Region: TraW_N; cl10149
405416000140	TraU protein; Region: TraU; pfam06834
405416000141	Type-F conjugative transfer system pilin assembly protein; Region: TrbC_Ftype; pfam09673
405416000142	conjugal transfer mating pair stabilization protein TraN; Reviewed; Region: PRK12355
405416000143	Type-1V conjugative transfer system mating pair stabilisation; Region: TraN; pfam06986
405416000144	F plasmid transfer operon protein; Region: TraF; pfam13728
405416000145	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
405416000146	catalytic residues [active]
405416000147	Conjugative relaxosome accessory transposon protein; Region: TraH; cl05580
405416000148	Conjugative relaxosome accessory transposon protein; Region: TraH; cl05580
405416000149	TraG-like protein, N-terminal region; Region: TraG_N; pfam07916
405416000150	Y-family of DNA polymerases; Region: PolY; cl12025
405416000151	active site
405416000152	Y-family of DNA polymerases; Region: PolY; cl12025
405416000153	DNA binding site [nucleotide binding]
405416000154	Domain of unknown function (DUF4113); Region: DUF4113; pfam13438
405416000155	Cytochrome b562; Region: Cytochrom_B562; cl01546
405416000156	DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939
405416000157	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
405416000158	ATP binding site [chemical binding]; other site
405416000159	Mg2+ binding site [ion binding]; other site
405416000160	G-X-G motif; other site
405416000161	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
405416000162	anchoring element; other site
405416000163	dimer interface [polypeptide binding]; other site
405416000164	ATP binding site [chemical binding]; other site
405416000165	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
405416000166	active site
405416000167	putative metal-binding site [ion binding]; other site
405416000168	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
405416000169	recombination protein F; Reviewed; Region: recF; PRK00064
405416000170	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
405416000171	Walker A/P-loop; other site
405416000172	ATP binding site [chemical binding]; other site
405416000173	Q-loop/lid; other site
405416000174	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
405416000175	ABC transporter signature motif; other site
405416000176	Walker B; other site
405416000177	D-loop; other site
405416000178	H-loop/switch region; other site
405416000179	DNA polymerase III subunit beta; Validated; Region: PRK05643
405416000180	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
405416000181	putative DNA binding surface [nucleotide binding]; other site
405416000182	dimer interface [polypeptide binding]; other site
405416000183	beta-clamp/clamp loader binding surface; other site
405416000184	beta-clamp/translesion DNA polymerase binding surface; other site
405416000185	DnaA N-terminal domain; Region: DnaA_N; pfam11638
405416000186	chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362
405416000187	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
405416000188	Walker A motif; other site
405416000189	ATP binding site [chemical binding]; other site
405416000190	Walker B motif; other site
405416000191	arginine finger; other site
405416000192	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
405416000193	DnaA box-binding interface [nucleotide binding]; other site
405416000194	50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399
405416000195	Ribonuclease P; Region: Ribonuclease_P; pfam00825
405416000196	hypothetical protein; Provisional; Region: PRK14386
405416000197	membrane protein insertase; Provisional; Region: PRK01318
405416000198	membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592
405416000199	tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291
405416000200	GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396
405416000201	trmE is a tRNA modification GTPase; Region: trmE; cd04164
405416000202	G1 box; other site
405416000203	GTP/Mg2+ binding site [chemical binding]; other site
405416000204	Switch I region; other site
405416000205	G2 box; other site
405416000206	Switch II region; other site
405416000207	G3 box; other site
405416000208	G4 box; other site
405416000209	G5 box; other site
405416000210	Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631
405416000211	Transcriptional regulators RcnR and FrmR, and related domains; this domain family was previously known as part of DUF156; Region: RcnR-FrmR-like_DUF156; cd10153
405416000212	putative metal binding site [ion binding]; other site
405416000213	putative homodimer interface [polypeptide binding]; other site
405416000214	putative homotetramer interface [polypeptide binding]; other site
405416000215	putative homodimer-homodimer interface [polypeptide binding]; other site
405416000216	putative allosteric switch controlling residues; other site
405416000217	Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230
405416000218	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
405416000219	Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651
405416000220	DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020
405416000221	dimerization domain [polypeptide binding]; other site
405416000222	dimer interface [polypeptide binding]; other site
405416000223	catalytic residues [active]
405416000224	Predicted membrane protein [Function unknown]; Region: COG2261
405416000225	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
405416000226	active site
405416000227	guanine deaminase; Provisional; Region: PRK09228
405416000228	Guanine deaminase (GDEase). Guanine deaminase is an aminohydrolase responsible for the conversion of guanine to xanthine and ammonia, the first step to utilize guanine as a nitrogen source. This reaction also removes the guanine base from the pool and...; Region: GDEase; cd01303
405416000229	active site
405416000230	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
405416000231	Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469
405416000232	[2Fe-2S] cluster binding site [ion binding]; other site
405416000233	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
405416000234	hydrophobic ligand binding site; other site
405416000235	Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754
405416000236	Bacterial protein of unknown function (DUF925); Region: DUF925; pfam06042
405416000237	integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718
405416000238	PAP2_like proteins, BcrC_like subfamily. Several members of this family have been annotated as bacitracin transport permeases, as it was suspected that they form the permease component of an ABC transporter system. It was shown, however, that BcrC from...; Region: PAP2_BcrC_like; cd03385
405416000239	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
405416000240	active site
405416000241	Bacterial low temperature requirement A protein (LtrA); Region: LtrA; cl01754
405416000242	UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase; Region: mpl; TIGR01081
405416000243	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
405416000244	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
405416000245	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
405416000246	Protein of unknown function, DUF486; Region: DUF486; cl01236
405416000247	AIR carboxylase; Region: AIRC; pfam00731
405416000248	phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019
405416000249	ATP-grasp domain; Region: ATP-grasp; pfam02222
405416000250	Transglycosylase SLT domain; Region: SLT_2; pfam13406
405416000251	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
405416000252	N-acetyl-D-glucosamine binding site [chemical binding]; other site
405416000253	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
405416000254	Dual-action HEIGH metallo-peptidase; Region: Peptidase_M57; pfam12388
405416000255	Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064
405416000256	active site
405416000257	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
405416000258	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
405416000259	nucleotide binding site [chemical binding]; other site
405416000260	GrpE; Region: GrpE; pfam01025
405416000261	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
405416000262	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
405416000263	dimer interface [polypeptide binding]; other site
405416000264	Transcriptional regulator [Transcription]; Region: LysR; COG0583
405416000265	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
405416000266	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
405416000267	putative effector binding pocket; other site
405416000268	dimerization interface [polypeptide binding]; other site
405416000269	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
405416000270	Protein of unknown function (DUF2424); Region: DUF2424; pfam10340
405416000271	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
405416000272	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
405416000273	peptidyl-prolyl cis-trans isomerase A (rotamase A); Provisional; Region: PRK10903
405416000274	cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920
405416000275	substrate binding site [chemical binding]; other site
405416000276	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
405416000277	Ankyrin repeats (many copies); Region: Ank_4; pfam13637
405416000278	Ankyrin repeats (many copies); Region: Ank_4; pfam13637
405416000279	Predicted flavoprotein [General function prediction only]; Region: COG0431
405416000280	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
405416000281	FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095
405416000282	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
405416000283	lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376
405416000284	isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743
405416000285	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
405416000286	active site
405416000287	HIGH motif; other site
405416000288	nucleotide binding site [chemical binding]; other site
405416000289	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
405416000290	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
405416000291	active site
405416000292	KMSKS motif; other site
405416000293	Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960
405416000294	tRNA binding surface [nucleotide binding]; other site
405416000295	anticodon binding site; other site
405416000296	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
405416000297	bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627
405416000298	FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064
405416000299	active site
405416000300	Riboflavin kinase; Region: Flavokinase; smart00904
405416000301	Tellurite resistance protein and related permeases [Inorganic ion transport and metabolism]; Region: TehA; COG1275
405416000302	Tellurite-resistance/Dicarboxylate Transporter (TDT) family includes sulfite sensitivity protein (sulfite efflux pump; SSU1); Region: TDT_SSU1; cd09318
405416000303	gating phenylalanine in ion channel; other site
405416000304	Phosphorylase superfamily; Region: PNP_UDP_1; cl00303
405416000305	pyrimidine utilization regulatory protein R; Region: RutR; TIGR03613
405416000306	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
405416000307	YcdC-like protein, C-terminal region; Region: TetR_C_3; pfam08362
405416000308	aliphatic sulfonates transport ATP-binding subunit; Provisional; Region: ssuB; PRK11247
405416000309	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
405416000310	Walker A/P-loop; other site
405416000311	ATP binding site [chemical binding]; other site
405416000312	Q-loop/lid; other site
405416000313	ABC transporter signature motif; other site
405416000314	Walker B; other site
405416000315	D-loop; other site
405416000316	H-loop/switch region; other site
405416000317	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
405416000318	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
405416000319	putative PBP binding loops; other site
405416000320	dimer interface [polypeptide binding]; other site
405416000321	ABC-ATPase subunit interface; other site
405416000322	alkanesulfonate monooxygenase; Provisional; Region: PRK00719
405416000323	Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094
405416000324	active site
405416000325	dimer interface [polypeptide binding]; other site
405416000326	non-prolyl cis peptide bond; other site
405416000327	insertion regions; other site
405416000328	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
405416000329	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
405416000330	substrate binding pocket [chemical binding]; other site
405416000331	membrane-bound complex binding site; other site
405416000332	hinge residues; other site
405416000333	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
405416000334	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
405416000335	substrate binding pocket [chemical binding]; other site
405416000336	membrane-bound complex binding site; other site
405416000337	N-acetylglutamate synthase; Validated; Region: PRK05279
405416000338	AAK_NAGS-ABP: N-acetylglutamate (NAG) kinase-like domain of the NAG Synthase (NAGS) of the arginine-biosynthesis pathway (ABP) found in gamma- and beta-proteobacteria and higher plant chloroplasts. Domain architecture of these NAGS consisted of an...; Region: AAK_NAGS-ABP; cd04237
405416000339	putative feedback inhibition sensing region; other site
405416000340	putative nucleotide binding site [chemical binding]; other site
405416000341	putative substrate binding site [chemical binding]; other site
405416000342	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
405416000343	Coenzyme A binding pocket [chemical binding]; other site
405416000344	Domain of unknown function (DUF3315); Region: DUF3315; pfam11776
405416000345	Domain of unknown function (DUF3315); Region: DUF3315; pfam11776
405416000346	putative oxoacyl-(acyl carrier protein) reductase; Provisional; Region: PRK08945
405416000347	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
405416000348	NAD(P) binding site [chemical binding]; other site
405416000349	active site
405416000350	phosphoglycolate phosphatase; Provisional; Region: PRK13222
405416000351	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
405416000352	active site
405416000353	motif I; other site
405416000354	motif II; other site
405416000355	bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134
405416000356	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
405416000357	S-adenosylmethionine binding site [chemical binding]; other site
405416000358	DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019
405416000359	catalytic residues [active]
405416000360	hinge region; other site
405416000361	alpha helical domain; other site
405416000362	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
405416000363	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
405416000364	DNA-binding transcriptional repressor FabR; Provisional; Region: PRK11202
405416000365	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
405416000366	Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_2; cd06216
405416000367	FMN reductase; Validated; Region: fre; PRK08051
405416000368	FAD binding pocket [chemical binding]; other site
405416000369	FAD binding motif [chemical binding]; other site
405416000370	phosphate binding motif [ion binding]; other site
405416000371	beta-alpha-beta structure motif; other site
405416000372	NAD binding pocket [chemical binding]; other site
405416000373	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
405416000374	catalytic loop [active]
405416000375	iron binding site [ion binding]; other site
405416000376	Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239
405416000377	The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506
405416000378	putative di-iron ligands [ion binding]; other site
405416000379	ribonuclease PH; Reviewed; Region: rph; PRK00173
405416000380	Ribonuclease PH; Region: RNase_PH_bact; cd11362
405416000381	hexamer interface [polypeptide binding]; other site
405416000382	active site
405416000383	phospholipase C, phosphocholine-specific, Pseudomonas-type; Region: PC_PLC; TIGR03396
405416000384	Phosphoesterase family; Region: Phosphoesterase; pfam04185
405416000385	Domain of unknown function (DUF756); Region: DUF756; pfam05506
405416000386	Domain of unknown function (DUF756); Region: DUF756; pfam05506
405416000387	quinolinate phosphoribosyltransferase; Validated; Region: PRK09016
405416000388	Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572
405416000389	dimerization interface [polypeptide binding]; other site
405416000390	active site
405416000391	N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023
405416000392	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
405416000393	amidase catalytic site [active]
405416000394	Zn binding residues [ion binding]; other site
405416000395	substrate binding site [chemical binding]; other site
405416000396	Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728
405416000397	MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123
405416000398	Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346
405416000399	FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545
405416000400	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
405416000401	Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346
405416000402	FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545
405416000403	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
405416000404	tyrosine kinase; Provisional; Region: PRK11519
405416000405	Chain length determinant protein; Region: Wzz; pfam02706
405416000406	G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807
405416000407	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
405416000408	Low molecular weight phosphatase family; Region: LMWPc; cd00115
405416000409	Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451
405416000410	active site
405416000411	Periplasmic protein involved in polysaccharide export, contains    SLBB domain of b-grasp fold [Cell wall/membrane/envelope biogenesis]; Region: Wza; COG1596
405416000412	Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563
405416000413	Vi polysaccharide biosynthesis protein TviB; Provisional; Region: PRK15182
405416000414	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
405416000415	UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984
405416000416	UDP-N-acetylglucosamine 4,6-dehydratase; Region: PseB; TIGR03589
405416000417	UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237
405416000418	NAD(P) binding site [chemical binding]; other site
405416000419	homodimer interface [polypeptide binding]; other site
405416000420	substrate binding site [chemical binding]; other site
405416000421	active site
405416000422	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
405416000423	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
405416000424	inhibitor-cofactor binding pocket; inhibition site
405416000425	pyridoxal 5'-phosphate binding site [chemical binding]; other site
405416000426	catalytic residue [active]
405416000427	CMP-NeuAc_Synthase activates N-acetylneuraminic acid by adding CMP moiety; Region: CMP-NeuAc_Synthase; cd02513
405416000428	ligand binding site; other site
405416000429	tetramer interface; other site
405416000430	pseudaminic acid biosynthesis-associated protein PseG; Region: PseG; TIGR03590
405416000431	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
405416000432	pseudaminic acid biosynthesis N-acetyl transferase; Region: PseH; TIGR03585
405416000433	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
405416000434	pseudaminic acid synthase; Region: PseI; TIGR03586
405416000435	NeuB family; Region: NeuB; pfam03102
405416000436	C-terminal SAF domain of sialic acid synthetase; Region: SAF_NeuB_like; cd11615
405416000437	NeuB binding interface [polypeptide binding]; other site
405416000438	putative substrate binding site [chemical binding]; other site
405416000439	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
405416000440	Capsule polysaccharide export protein [Cell envelope biogenesis, outer membrane]; Region: KpsS; COG3562
405416000441	Core-2/I-Branching enzyme; Region: Branch; pfam02485
405416000442	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
405416000443	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
405416000444	active site
405416000445	Bacterial sugar transferase; Region: Bac_transf; pfam02397
405416000446	Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541
405416000447	dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209
405416000448	active site
405416000449	tetramer interface; other site
405416000450	Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004
405416000451	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
405416000452	UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984
405416000453	glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179
405416000454	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015
405416000455	active site
405416000456	dimer interface [polypeptide binding]; other site
405416000457	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016
405416000458	dimer interface [polypeptide binding]; other site
405416000459	active site
405416000460	UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247
405416000461	UDP-glucose 4-epimerase; Region: PLN02240
405416000462	NAD binding site [chemical binding]; other site
405416000463	homodimer interface [polypeptide binding]; other site
405416000464	active site
405416000465	substrate binding site [chemical binding]; other site
405416000466	phosphomannomutase CpsG; Provisional; Region: PRK15414
405416000467	The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089
405416000468	active site
405416000469	substrate binding site [chemical binding]; other site
405416000470	metal binding site [ion binding]; metal-binding site
405416000471	L-lactate permease; Provisional; Region: PRK10420
405416000472	glycolate transporter; Provisional; Region: PRK09695
405416000473	DNA-binding transcriptional repressor LldR; Provisional; Region: PRK10421
405416000474	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
405416000475	DNA-binding site [nucleotide binding]; DNA binding site
405416000476	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
405416000477	L-lactate dehydrogenase; Provisional; Region: lldD; PRK11197
405416000478	Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809
405416000479	active site
405416000480	substrate binding site [chemical binding]; other site
405416000481	FMN binding site [chemical binding]; other site
405416000482	putative catalytic residues [active]
405416000483	D-lactate dehydrogenase; Provisional; Region: PRK11183
405416000484	FAD binding domain; Region: FAD_binding_4; pfam01565
405416000485	D-lactate dehydrogenase, membrane binding; Region: Lact-deh-memb; pfam09330
405416000486	aromatic amino acid aminotransferase; Provisional; Region: PRK09257
405416000487	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
405416000488	pyridoxal 5'-phosphate binding site [chemical binding]; other site
405416000489	homodimer interface [polypeptide binding]; other site
405416000490	catalytic residue [active]
405416000491	Transcriptional regulators [Transcription]; Region: GntR; COG1802
405416000492	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
405416000493	DNA-binding site [nucleotide binding]; DNA binding site
405416000494	FCD domain; Region: FCD; pfam07729
405416000495	Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714
405416000496	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
405416000497	tetramer interface [polypeptide binding]; other site
405416000498	active site
405416000499	Mg2+/Mn2+ binding site [ion binding]; other site
405416000500	Citrate synthase [Energy production and conversion]; Region: GltA; COG0372
405416000501	methylcitrate synthase; Provisional; Region: PRK12351
405416000502	oxalacetate binding site [chemical binding]; other site
405416000503	citrylCoA binding site [chemical binding]; other site
405416000504	coenzyme A binding site [chemical binding]; other site
405416000505	catalytic triad [active]
405416000506	2-methylisocitrate dehydratase, Fe/S-dependent; Region: 2met_isocit_dHY; TIGR02333
405416000507	Aconitase A catalytic domain; Region: AcnA_IRP; cd01586
405416000508	substrate binding site [chemical binding]; other site
405416000509	ligand binding site [chemical binding]; other site
405416000510	Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215
405416000511	substrate binding site [chemical binding]; other site
405416000512	Restriction endonuclease; Region: Mrr_cat; pfam04471
405416000513	Protein of unknown function (DUF1451); Region: DUF1451; pfam07295
405416000514	Domain of unknown function (DUF4126); Region: DUF4126; pfam13548
405416000515	3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK07967
405416000516	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
405416000517	dimer interface [polypeptide binding]; other site
405416000518	active site
405416000519	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
405416000520	Sel1-like repeats; Region: SEL1; smart00671
405416000521	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
405416000522	binding surface
405416000523	TPR motif; other site
405416000524	Sel1-like repeats; Region: SEL1; smart00671
405416000525	Uncharacterized protein conserved in bacteria [Function unknown]; Region: VgrG; COG3501
405416000526	Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954
405416000527	Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717
405416000528	Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296
405416000529	Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; pfam10106
405416000530	Protein of unknown function (DUF3396); Region: DUF3396; pfam11876
405416000531	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
405416000532	NAD(P) binding site [chemical binding]; other site
405416000533	active site
405416000534	Predicted membrane protein [Function unknown]; Region: COG4420
405416000535	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
405416000536	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
405416000537	active site
405416000538	Protein of unknown function (DUF1260); Region: DUF1260; pfam06877
405416000539	SnoaL-like domain; Region: SnoaL_2; pfam12680
405416000540	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
405416000541	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
405416000542	N-terminal plug; other site
405416000543	ligand-binding site [chemical binding]; other site
405416000544	Predicted membrane protein [Function unknown]; Region: COG3503
405416000545	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
405416000546	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
405416000547	putative DNA binding site [nucleotide binding]; other site
405416000548	putative Zn2+ binding site [ion binding]; other site
405416000549	AsnC family; Region: AsnC_trans_reg; pfam01037
405416000550	D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711
405416000551	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
405416000552	mRNA stabilisation; Region: mRNA_stabil; pfam13929
405416000553	alanine racemase; Reviewed; Region: dadX; PRK03646
405416000554	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827
405416000555	active site
405416000556	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
405416000557	substrate binding site [chemical binding]; other site
405416000558	catalytic residues [active]
405416000559	dimer interface [polypeptide binding]; other site
405416000560	This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function.  The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150
405416000561	homotrimer interaction site [polypeptide binding]; other site
405416000562	putative active site [active]
405416000563	D-alanine/D-serine/glycine permease; Provisional; Region: PRK11049
405416000564	D-alanine/D-serine/glycine permease; Provisional; Region: PRK11049
405416000565	Transcriptional regulator [Transcription]; Region: LysR; COG0583
405416000566	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
405416000567	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
405416000568	dimerization interface [polypeptide binding]; other site
405416000569	Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085
405416000570	methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722
405416000571	tetrameric interface [polypeptide binding]; other site
405416000572	NAD binding site [chemical binding]; other site
405416000573	catalytic residues [active]
405416000574	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
405416000575	3-hydroxyisobutyrate dehydrogenase; Region: HIBADH; TIGR01692
405416000576	Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365
405416000577	Domain of unknown function (DUF3448); Region: DUF3448; pfam11930
405416000578	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
405416000579	acyl-activating enzyme (AAE) consensus motif; other site
405416000580	AMP binding site [chemical binding]; other site
405416000581	active site
405416000582	CoA binding site [chemical binding]; other site
405416000583	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
405416000584	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
405416000585	active site
405416000586	enoyl-CoA hydratase; Provisional; Region: PRK05862
405416000587	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
405416000588	substrate binding site [chemical binding]; other site
405416000589	oxyanion hole (OAH) forming residues; other site
405416000590	trimer interface [polypeptide binding]; other site
405416000591	3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617
405416000592	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
405416000593	substrate binding site [chemical binding]; other site
405416000594	oxyanion hole (OAH) forming residues; other site
405416000595	trimer interface [polypeptide binding]; other site
405416000596	2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766
405416000597	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
405416000598	metabolite-proton symporter; Region: 2A0106; TIGR00883
405416000599	putative substrate translocation pore; other site
405416000600	Autoinducer synthetase; Region: Autoind_synth; cl17404
405416000601	DNA-binding transcriptional activator SdiA; Provisional; Region: PRK10188
405416000602	Autoinducer binding domain; Region: Autoind_bind; pfam03472
405416000603	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
405416000604	DNA binding residues [nucleotide binding]
405416000605	dimerization interface [polypeptide binding]; other site
405416000606	acyl-CoA synthetase; Validated; Region: PRK05850
405416000607	Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931
405416000608	acyl-activating enzyme (AAE) consensus motif; other site
405416000609	active site
405416000610	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
405416000611	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
405416000612	active site
405416000613	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
405416000614	Condensation domain; Region: Condensation; pfam00668
405416000615	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
405416000616	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
405416000617	The adenylation domain of nonribosomal peptide synthetases (NRPS), including salinosporamide A polyketide synthase; Region: A_NRPS_Ta1_like; cd12116
405416000618	acyl-activating enzyme (AAE) consensus motif; other site
405416000619	AMP binding site [chemical binding]; other site
405416000620	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
405416000621	Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319
405416000622	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
405416000623	hydrophobic ligand binding site; other site
405416000624	Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033
405416000625	Protein of unknown function (DUF1329); Region: DUF1329; pfam07044
405416000626	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
405416000627	NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370
405416000628	NAD(P) binding site [chemical binding]; other site
405416000629	active site
405416000630	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
405416000631	Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303
405416000632	catalytic site [active]
405416000633	4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648
405416000634	Stress-induced morphogen (activity unknown) [Signal transduction mechanisms]; Region: BolA; COG0271
405416000635	Invasion gene expression up-regulator, SirB; Region: SirB; cl01184
405416000636	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
405416000637	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
405416000638	P-loop; other site
405416000639	Magnesium ion binding site [ion binding]; other site
405416000640	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
405416000641	Magnesium ion binding site [ion binding]; other site
405416000642	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
405416000643	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
405416000644	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
405416000645	Predicted membrane protein [Function unknown]; Region: COG2259
405416000646	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399
405416000647	GMP synthase; Reviewed; Region: guaA; PRK00074
405416000648	Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742
405416000649	AMP/PPi binding site [chemical binding]; other site
405416000650	candidate oxyanion hole; other site
405416000651	catalytic triad [active]
405416000652	potential glutamine specificity residues [chemical binding]; other site
405416000653	The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997
405416000654	ATP Binding subdomain [chemical binding]; other site
405416000655	Ligand Binding sites [chemical binding]; other site
405416000656	Dimerization subdomain; other site
405416000657	aminoglycoside resistance protein; Provisional; Region: PRK13746
405416000658	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
405416000659	active site
405416000660	NTP binding site [chemical binding]; other site
405416000661	metal binding triad [ion binding]; metal-binding site
405416000662	antibiotic binding site [chemical binding]; other site
405416000663	Domain of unknown function (DUF4111); Region: DUF4111; pfam13427
405416000664	Predicted transcriptional regulators [Transcription]; Region: COG1695
405416000665	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
405416000666	Domain of Unknown Function with PDB structure (DUF3861); Region: DUF3861; pfam12977
405416000667	Pirin; Region: Pirin; pfam02678
405416000668	Pirin-related protein [General function prediction only]; Region: COG1741
405416000669	Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726
405416000670	OsmC-like protein; Region: OsmC; pfam02566
405416000671	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
405416000672	GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046
405416000673	putative C-terminal domain interface [polypeptide binding]; other site
405416000674	putative GSH binding site (G-site) [chemical binding]; other site
405416000675	putative dimer interface [polypeptide binding]; other site
405416000676	C-terminal, alpha helical domain of GTT1-like Glutathione S-transferases; Region: GST_C_GTT1_like; cd03189
405416000677	putative N-terminal domain interface [polypeptide binding]; other site
405416000678	putative dimer interface [polypeptide binding]; other site
405416000679	putative substrate binding pocket (H-site) [chemical binding]; other site
405416000680	Sporulation related domain; Region: SPOR; pfam05036
405416000681	Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016
405416000682	Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018
405416000683	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
405416000684	active site
405416000685	HIGH motif; other site
405416000686	nucleotide binding site [chemical binding]; other site
405416000687	catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
405416000688	KMSK motif region; other site
405416000689	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
405416000690	tRNA binding surface [nucleotide binding]; other site
405416000691	anticodon binding site; other site
405416000692	malate dehydrogenase; Provisional; Region: PRK13529
405416000693	Malic enzyme, N-terminal domain; Region: malic; pfam00390
405416000694	NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312
405416000695	NAD(P) binding site [chemical binding]; other site
405416000696	Dyp-type peroxidase family; Region: Dyp_perox; cl01067
405416000697	LysE type translocator; Region: LysE; cl00565
405416000698	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
405416000699	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
405416000700	ABC-ATPase subunit  interface; other site
405416000701	dimer interface [polypeptide binding]; other site
405416000702	putative PBP binding regions; other site
405416000703	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
405416000704	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
405416000705	Walker A/P-loop; other site
405416000706	ATP binding site [chemical binding]; other site
405416000707	Q-loop/lid; other site
405416000708	ABC transporter signature motif; other site
405416000709	Walker B; other site
405416000710	D-loop; other site
405416000711	H-loop/switch region; other site
405416000712	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cl17326
405416000713	metal binding site 2 [ion binding]; metal-binding site
405416000714	putative DNA binding helix; other site
405416000715	metal binding site 1 [ion binding]; metal-binding site
405416000716	dimer interface [polypeptide binding]; other site
405416000717	structural Zn2+ binding site [ion binding]; other site
405416000718	Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297
405416000719	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
405416000720	intersubunit interface [polypeptide binding]; other site
405416000721	F0F1 ATP synthase subunit I; Validated; Region: PRK05760
405416000722	F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356
405416000723	F0F1 ATP synthase subunit A; Validated; Region: PRK05815
405416000724	F0F1 ATP synthase subunit C; Validated; Region: PRK06876
405416000725	F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711
405416000726	F0F1 ATP synthase subunit B; Validated; Region: PRK05759
405416000727	F0F1 ATP synthase subunit delta; Validated; Region: PRK05758
405416000728	ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213
405416000729	F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281
405416000730	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
405416000731	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
405416000732	Walker A motif; other site
405416000733	ATP binding site [chemical binding]; other site
405416000734	Walker B motif; other site
405416000735	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
405416000736	mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151
405416000737	core domain interface [polypeptide binding]; other site
405416000738	delta subunit interface [polypeptide binding]; other site
405416000739	epsilon subunit interface [polypeptide binding]; other site
405416000740	F0F1 ATP synthase subunit beta; Validated; Region: PRK09280
405416000741	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
405416000742	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
405416000743	alpha subunit interaction interface [polypeptide binding]; other site
405416000744	Walker A motif; other site
405416000745	ATP binding site [chemical binding]; other site
405416000746	Walker B motif; other site
405416000747	inhibitor binding site; inhibition site
405416000748	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
405416000749	F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571
405416000750	mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152
405416000751	gamma subunit interface [polypeptide binding]; other site
405416000752	epsilon subunit interface [polypeptide binding]; other site
405416000753	LBP interface [polypeptide binding]; other site
405416000754	Protein of unknown function (DUF2846); Region: DUF2846; pfam11008
405416000755	Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340
405416000756	catalytic residues [active]
405416000757	dimer interface [polypeptide binding]; other site
405416000758	Helix-turn-helix domain; Region: HTH_18; pfam12833
405416000759	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
405416000760	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
405416000761	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
405416000762	putative substrate translocation pore; other site
405416000763	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
405416000764	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
405416000765	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
405416000766	EamA-like transporter family; Region: EamA; pfam00892
405416000767	EamA-like transporter family; Region: EamA; pfam00892
405416000768	Telomere recombination; Region: Sua5_yciO_yrdC; cl00305
405416000769	DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481
405416000770	DNA protecting protein DprA; Region: dprA; TIGR00732
405416000771	Uncharacterized protein containing LysM domain [Function unknown]; Region: XkdP; COG1652
405416000772	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
405416000773	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
405416000774	active site
405416000775	catalytic residues [active]
405416000776	metal binding site [ion binding]; metal-binding site
405416000777	TonB-dependent copper receptor; Region: TonB-copper; TIGR01778
405416000778	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
405416000779	N-terminal plug; other site
405416000780	ligand-binding site [chemical binding]; other site
405416000781	Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; pfam09995
405416000782	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
405416000783	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
405416000784	Acetyltransferase (GNAT) domain; Region: Acetyltransf_9; pfam13527
405416000785	Coenzyme A binding pocket [chemical binding]; other site
405416000786	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
405416000787	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
405416000788	dimer interface [polypeptide binding]; other site
405416000789	pyridoxal 5'-phosphate binding site [chemical binding]; other site
405416000790	catalytic residue [active]
405416000791	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
405416000792	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
405416000793	N-acetyl-D-glucosamine binding site [chemical binding]; other site
405416000794	catalytic residue [active]
405416000795	Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655
405416000796	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
405416000797	Protein of unknown function (DUF2938); Region: DUF2938; pfam11158
405416000798	Cu(I)-responsive transcriptional regulator; Region: CueR; TIGR02044
405416000799	Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg6; cd04781
405416000800	DNA binding residues [nucleotide binding]
405416000801	putative dimer interface [polypeptide binding]; other site
405416000802	putative metal binding residues [ion binding]; other site
405416000803	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4222
405416000804	Class II Chelatase: a family of ATP-independent monomeric or homodimeric enzymes that catalyze the insertion of metal into protoporphyrin rings. This family includes protoporphyrin IX ferrochelatase (HemH), sirohydrochlorin ferrochelatase (SirB) and the...; Region: Chelatase_Class_II; cl02784
405416000805	hypothetical protein; Provisional; Region: PRK01254
405416000806	Radical SAM N-terminal; Region: Radical_SAM_N; pfam08497
405416000807	Radical SAM N-terminal; Region: Radical_SAM_N; pfam08497
405416000808	Domain of unknown function (DUF3362); Region: DUF3362; pfam11842
405416000809	Protein of unknown function (DUF2726); Region: DUF2726; pfam10881
405416000810	This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function.  The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150
405416000811	homotrimer interaction site [polypeptide binding]; other site
405416000812	putative active site [active]
405416000813	DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586
405416000814	active site
405416000815	DNA polymerase IV; Validated; Region: PRK02406
405416000816	DNA binding site [nucleotide binding]
405416000817	Uncharacterized bacterial muramidase containing a glycosyl hydrolase family 25 (GH25) catalytic domain. Endo-N-acetylmuramidases are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis...; Region: GH25_muramidase_1; cd06413
405416000818	active site
405416000819	Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183
405416000820	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
405416000821	putative transporter; Provisional; Region: PRK10504
405416000822	putative substrate translocation pore; other site
405416000823	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
405416000824	Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695
405416000825	Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861
405416000826	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
405416000827	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
405416000828	Transporter associated domain; Region: CorC_HlyC; smart01091
405416000829	hypothetical protein; Provisional; Region: PRK01752
405416000830	SEC-C motif; Region: SEC-C; pfam02810
405416000831	Predicted membrane protein [Function unknown]; Region: COG2860
405416000832	UPF0126 domain; Region: UPF0126; pfam03458
405416000833	UPF0126 domain; Region: UPF0126; pfam03458
405416000834	benzoate transport; Region: 2A0115; TIGR00895
405416000835	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
405416000836	putative substrate translocation pore; other site
405416000837	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
405416000838	DNA topoisomerase IV subunit A; Validated; Region: PRK05561
405416000839	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
405416000840	CAP-like domain; other site
405416000841	active site
405416000842	primary dimer interface [polypeptide binding]; other site
405416000843	Long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07059
405416000844	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
405416000845	Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936
405416000846	acyl-activating enzyme (AAE) consensus motif; other site
405416000847	putative AMP binding site [chemical binding]; other site
405416000848	putative active site [active]
405416000849	putative CoA binding site [chemical binding]; other site
405416000850	Predicted membrane protein [Function unknown]; Region: COG3686
405416000851	Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412
405416000852	dimer interface [polypeptide binding]; other site
405416000853	substrate binding site [chemical binding]; other site
405416000854	metal binding sites [ion binding]; metal-binding site
405416000855	outer membrane porin, OprD family; Region: OprD; pfam03573
405416000856	DDE domain; Region: DDE_Tnp_IS240; pfam13610
405416000857	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
405416000858	Domain of unknown function (DUF3330); Region: DUF3330; pfam11809
405416000859	integrase/recombinase; Provisional; Region: PRK15417
405416000860	IntI (E2) integrases, site-specific tyrosine recombinases, DNA breaking-rejoining enzymes, N- and C-terminal domains. This CD includes integrases which are components of multiresistant integrons and mediate recombination between a proximal attI site and...; Region: INT_IntI; cd01193
405416000861	Int/Topo IB signature motif; other site
405416000862	Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523
405416000863	Siderophore biosynthesis protein domain; Region: AlcB; smart01006
405416000864	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
405416000865	Coenzyme A binding pocket [chemical binding]; other site
405416000866	Beta-lactamase class D [Defense mechanisms]; Region: COG2602
405416000867	Small Multidrug Resistance protein; Region: Multi_Drug_Res; pfam00893
405416000868	DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
405416000869	dihydropteroate synthase; Region: DHPS; TIGR01496
405416000870	substrate binding pocket [chemical binding]; other site
405416000871	dimer interface [polypeptide binding]; other site
405416000872	inhibitor binding site; inhibition site
405416000873	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
405416000874	Coenzyme A binding pocket [chemical binding]; other site
405416000875	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
405416000876	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
405416000877	catalytic residues [active]
405416000878	catalytic nucleophile [active]
405416000879	Presynaptic Site I dimer interface [polypeptide binding]; other site
405416000880	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
405416000881	Synaptic Flat tetramer interface [polypeptide binding]; other site
405416000882	Synaptic Site I dimer interface [polypeptide binding]; other site
405416000883	DNA binding site [nucleotide binding]
405416000884	Bacterial conjugation TrbI-like protein; Region: TrbI; cl04242
405416000885	Cd(II)/Pb(II)-responsive transcriptional regulator; Region: CadR-PbrR; TIGR02047
405416000886	Helix-Turn-Helix DNA binding domain of the CadR and PbrR transcription regulators; Region: HTH_CadR-PbrR; cd04784
405416000887	DNA binding residues [nucleotide binding]
405416000888	dimer interface [polypeptide binding]; other site
405416000889	putative metal binding site [ion binding]; other site
405416000890	Heavy-metal-associated domain; Region: HMA; pfam00403
405416000891	metal-binding site [ion binding]
405416000892	Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230
405416000893	lipoprotein signal peptidase; Provisional; Region: PRK14776
405416000894	Transposase; Region: DDE_Tnp_ISL3; pfam01610
405416000895	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
405416000896	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
405416000897	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
405416000898	Sulfate transporter family; Region: Sulfate_transp; pfam00916
405416000899	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
405416000900	Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606
405416000901	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
405416000902	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078
405416000903	Membrane fusogenic activity; Region: BMFP; pfam04380
405416000904	Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347
405416000905	Nitrogen regulatory protein P-II; Region: P-II; smart00938
405416000906	Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004
405416000907	transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464
405416000908	ATP cone domain; Region: ATP-cone; pfam03477
405416000909	bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase; Provisional; Region: ribD; PRK10786
405416000910	Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284
405416000911	catalytic motif [active]
405416000912	Zn binding site [ion binding]; other site
405416000913	RibD C-terminal domain; Region: RibD_C; cl17279
405416000914	D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; cl17344
405416000915	riboflavin synthase subunit alpha; Provisional; Region: PRK09289
405416000916	Lumazine binding domain; Region: Lum_binding; pfam00677
405416000917	Lumazine binding domain; Region: Lum_binding; pfam00677
405416000918	DNA polymerase III chi subunit, HolC; Region: DNA_pol3_chi; pfam04364
405416000919	multifunctional aminopeptidase A; Provisional; Region: PRK00913
405416000920	Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433
405416000921	interface (dimer of trimers) [polypeptide binding]; other site
405416000922	Substrate-binding/catalytic site; other site
405416000923	Zn-binding sites [ion binding]; other site
405416000924	Predicted permeases [General function prediction only]; Region: COG0795; cl12074
405416000925	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
405416000926	Predicted permeases [General function prediction only]; Region: COG0795; cl12074
405416000927	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
405416000928	phosphoglyceromutase; Provisional; Region: PRK05434
405416000929	Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696
405416000930	Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793
405416000931	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
405416000932	PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cd00136
405416000933	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
405416000934	Catalytic dyad [active]
405416000935	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
405416000936	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
405416000937	active site
405416000938	phosphorylation site [posttranslational modification]
405416000939	intermolecular recognition site; other site
405416000940	dimerization interface [polypeptide binding]; other site
405416000941	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
405416000942	Walker A motif; other site
405416000943	ATP binding site [chemical binding]; other site
405416000944	Walker B motif; other site
405416000945	arginine finger; other site
405416000946	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
405416000947	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
405416000948	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
405416000949	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
405416000950	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
405416000951	dimer interface [polypeptide binding]; other site
405416000952	phosphorylation site [posttranslational modification]
405416000953	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
405416000954	ATP binding site [chemical binding]; other site
405416000955	Mg2+ binding site [ion binding]; other site
405416000956	G-X-G motif; other site
405416000957	response regulator; Provisional; Region: PRK09483
405416000958	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
405416000959	active site
405416000960	phosphorylation site [posttranslational modification]
405416000961	intermolecular recognition site; other site
405416000962	dimerization interface [polypeptide binding]; other site
405416000963	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
405416000964	DNA binding residues [nucleotide binding]
405416000965	dimerization interface [polypeptide binding]; other site
405416000966	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
405416000967	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768
405416000968	threonine synthase; Reviewed; Region: PRK06721
405416000969	Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of  threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563
405416000970	homodimer interface [polypeptide binding]; other site
405416000971	pyridoxal 5'-phosphate binding site [chemical binding]; other site
405416000972	catalytic residue [active]
405416000973	homoserine dehydrogenase; Provisional; Region: PRK06349
405416000974	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
405416000975	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
405416000976	ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881
405416000977	Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651
405416000978	DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020
405416000979	dimerization domain [polypeptide binding]; other site
405416000980	dimer interface [polypeptide binding]; other site
405416000981	catalytic residues [active]
405416000982	site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283
405416000983	XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798
405416000984	active site
405416000985	Int/Topo IB signature motif; other site
405416000986	FeoA domain; Region: FeoA; pfam04023
405416000987	Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370
405416000988	Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879
405416000989	G1 box; other site
405416000990	GTP/Mg2+ binding site [chemical binding]; other site
405416000991	Switch I region; other site
405416000992	G2 box; other site
405416000993	G3 box; other site
405416000994	Switch II region; other site
405416000995	G4 box; other site
405416000996	G5 box; other site
405416000997	Nucleoside recognition; Region: Gate; pfam07670
405416000998	Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664
405416000999	Nucleoside recognition; Region: Gate; pfam07670
405416001000	UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK03803
405416001001	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
405416001002	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
405416001003	cell division protein FtsW; Region: ftsW; TIGR02614
405416001004	glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710
405416001005	active site
405416001006	nucleotide binding site [chemical binding]; other site
405416001007	HIGH motif; other site
405416001008	KMSKS motif; other site
405416001009	RNA polymerase-binding protein DksA; Region: dksA; TIGR02420
405416001010	Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402
405416001011	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
405416001012	active site
405416001013	metal binding site [ion binding]; metal-binding site
405416001014	hexamer interface [polypeptide binding]; other site
405416001015	ADP-ribose pyrophosphatase NudF; Provisional; Region: nudF; PRK10729
405416001016	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
405416001017	dimer interface [polypeptide binding]; other site
405416001018	ADP-ribose binding site [chemical binding]; other site
405416001019	active site
405416001020	nudix motif; other site
405416001021	metal binding site [ion binding]; metal-binding site
405416001022	thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284
405416001023	ThiC-associated domain; Region: ThiC-associated; pfam13667
405416001024	Thiamine biosynthesis protein ThiC [Coenzyme metabolism]; Region: ThiC; COG0422
405416001025	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
405416001026	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
405416001027	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
405416001028	EamA-like transporter family; Region: EamA; pfam00892
405416001029	type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844
405416001030	transcriptional regulator PhoU; Provisional; Region: PRK11115
405416001031	PhoU domain; Region: PhoU; pfam01895
405416001032	PhoU domain; Region: PhoU; pfam01895
405416001033	oxidative damage protection protein; Provisional; Region: PRK05408
405416001034	argininosuccinate lyase; Provisional; Region: PRK00855
405416001035	Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359
405416001036	active sites [active]
405416001037	tetramer interface [polypeptide binding]; other site
405416001038	Histidine kinase; Region: His_kinase; pfam06580
405416001039	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
405416001040	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
405416001041	active site
405416001042	phosphorylation site [posttranslational modification]
405416001043	intermolecular recognition site; other site
405416001044	dimerization interface [polypeptide binding]; other site
405416001045	LytTr DNA-binding domain; Region: LytTR; smart00850
405416001046	porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072
405416001047	Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494
405416001048	domain interfaces; other site
405416001049	active site
405416001050	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
405416001051	Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587
405416001052	active site
405416001053	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
405416001054	active site
405416001055	H-NS histone family; Region: Histone_HNS; pfam00816
405416001056	Domain in histone-like proteins of HNS family; Region: HNS; smart00528
405416001057	Type II secretion system (T2SS), protein N; Region: T2SN; pfam01203
405416001058	type II secretion system protein C; Region: typeII_sec_gspC; TIGR01713
405416001059	Type IV pilus biogenesis; Region: Pilus_PilP; pfam11356
405416001060	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
405416001061	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
405416001062	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
405416001063	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
405416001064	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
405416001065	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
405416001066	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
405416001067	phosphopeptide binding site; other site
405416001068	phosphoglycolate phosphatase; Provisional; Region: PRK13222
405416001069	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
405416001070	motif II; other site
405416001071	anthranilate synthase component I; Provisional; Region: PRK13565
405416001072	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
405416001073	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
405416001074	Elongation factor Tu GTP binding domain; Region: GTP_EFTU; pfam00009
405416001075	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
405416001076	G1 box; other site
405416001077	GEF interaction site [polypeptide binding]; other site
405416001078	GTP/Mg2+ binding site [chemical binding]; other site
405416001079	Switch I region; other site
405416001080	G2 box; other site
405416001081	G3 box; other site
405416001082	Switch II region; other site
405416001083	G4 box; other site
405416001084	G5 box; other site
405416001085	preprotein translocase subunit SecE; Reviewed; Region: secE; PRK05740
405416001086	transcription antitermination protein NusG; Validated; Region: nusG; PRK05609
405416001087	Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891
405416001088	putative homodimer interface [polypeptide binding]; other site
405416001089	NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091
405416001090	heterodimer interface [polypeptide binding]; other site
405416001091	homodimer interface [polypeptide binding]; other site
405416001092	50S ribosomal protein L11; Validated; Region: rplK; PRK00140
405416001093	Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349
405416001094	23S rRNA interface [nucleotide binding]; other site
405416001095	L7/L12 interface [polypeptide binding]; other site
405416001096	putative thiostrepton binding site; other site
405416001097	L25 interface [polypeptide binding]; other site
405416001098	Ribosomal protein L1.  The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA.  In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403
405416001099	mRNA/rRNA interface [nucleotide binding]; other site
405416001100	Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797
405416001101	23S rRNA interface [nucleotide binding]; other site
405416001102	Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site
405416001103	Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387
405416001104	core dimer interface [polypeptide binding]; other site
405416001105	peripheral dimer interface [polypeptide binding]; other site
405416001106	L10 interface [polypeptide binding]; other site
405416001107	L11 interface [polypeptide binding]; other site
405416001108	putative EF-Tu interaction site [polypeptide binding]; other site
405416001109	putative EF-G interaction site [polypeptide binding]; other site
405416001110	DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405
405416001111	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585
405416001112	RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561
405416001113	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
405416001114	RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562
405416001115	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
405416001116	RPB1 interaction site [polypeptide binding]; other site
405416001117	RPB11 interaction site [polypeptide binding]; other site
405416001118	RPB10 interaction site [polypeptide binding]; other site
405416001119	RPB3 interaction site [polypeptide binding]; other site
405416001120	RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997
405416001121	DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086
405416001122	RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663
405416001123	RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983
405416001124	RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000
405416001125	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
405416001126	Rpb1 - Rpb6 interaction site [polypeptide binding]; other site
405416001127	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
405416001128	Rpb1 - Rpb6 interaction site [polypeptide binding]; other site
405416001129	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
405416001130	DNA binding site [nucleotide binding]
405416001131	Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site
405416001132	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
405416001133	active site 2 [active]
405416001134	active site 1 [active]
405416001135	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
405416001136	Putative serine esterase (DUF676); Region: DUF676; pfam05057
405416001137	Predicted permease [General function prediction only]; Region: COG2056
405416001138	Na+-H+ antiporter family; Region: Na_H_antiport_2; pfam13726
405416001139	Outer membrane protein W [Cell envelope biogenesis, outer membrane]; Region: OmpW; COG3047
405416001140	Protein of unknown function (DUF1311); Region: DUF1311; pfam07007
405416001141	heat shock protein 90; Provisional; Region: PRK05218
405416001142	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
405416001143	ATP binding site [chemical binding]; other site
405416001144	Mg2+ binding site [ion binding]; other site
405416001145	G-X-G motif; other site
405416001146	Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761
405416001147	DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024
405416001148	catalytic residues [active]
405416001149	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
405416001150	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
405416001151	DNA binding residues [nucleotide binding]
405416001152	Predicted esterase of the alpha/beta hydrolase fold [General function prediction only]; Region: COG3545
405416001153	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
405416001154	hypothetical protein; Provisional; Region: PRK10215
405416001155	3-ketoacyl-CoA thiolase; Reviewed; Region: fadA; PRK08947
405416001156	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
405416001157	dimer interface [polypeptide binding]; other site
405416001158	active site
405416001159	multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadB; PRK11730
405416001160	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
405416001161	substrate binding site [chemical binding]; other site
405416001162	oxyanion hole (OAH) forming residues; other site
405416001163	trimer interface [polypeptide binding]; other site
405416001164	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
405416001165	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
405416001166	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
405416001167	Aspartyl/asparaginyl beta-hydroxylase and related dioxygenases [Posttranslational modification, protein turnover, chaperones]; Region: COG3555
405416001168	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220
405416001169	excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558
405416001170	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
405416001171	GIY-YIG motif/motif A; other site
405416001172	active site
405416001173	catalytic site [active]
405416001174	putative DNA binding site [nucleotide binding]; other site
405416001175	metal binding site [ion binding]; metal-binding site
405416001176	UvrB/uvrC motif; Region: UVR; pfam02151
405416001177	UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459
405416001178	Thioesterase-like superfamily; Region: 4HBT_3; pfam13622
405416001179	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445
405416001180	active site
405416001181	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II; cd00556
405416001182	active site
405416001183	dimer interface [polypeptide binding]; other site
405416001184	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453
405416001185	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
405416001186	Helix-turn-helix domain; Region: HTH_18; pfam12833
405416001187	Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350
405416001188	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
405416001189	DNA binding site [nucleotide binding]
405416001190	active site
405416001191	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_2; pfam13532
405416001192	IclR helix-turn-helix domain; Region: HTH_IclR; cl17605
405416001193	Transcriptional regulator [Transcription]; Region: IclR; COG1414
405416001194	Bacterial transcriptional regulator; Region: IclR; pfam01614
405416001195	Fusaric acid resistance protein family; Region: FUSC; pfam04632
405416001196	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
405416001197	Protein of unknown function (DUF1656); Region: DUF1656; pfam07869
405416001198	Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566
405416001199	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
405416001200	HlyD family secretion protein; Region: HlyD_3; pfam13437
405416001201	Holliday junction resolvase-like protein; Reviewed; Region: PRK00109
405416001202	Uncharacterized ACR, COG1678; Region: DUF179; pfam02622
405416001203	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497
405416001204	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
405416001205	Walker A/P-loop; other site
405416001206	ATP binding site [chemical binding]; other site
405416001207	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
405416001208	ABC transporter signature motif; other site
405416001209	Walker B; other site
405416001210	D-loop; other site
405416001211	H-loop/switch region; other site
405416001212	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
405416001213	binding surface
405416001214	Tetratricopeptide repeat; Region: TPR_16; pfam13432
405416001215	TPR motif; other site
405416001216	Protein of unknown function (DUF1255); Region: DUF1255; pfam06865
405416001217	23S rRNA (guanosine-2'-O-)-methyltransferase; Provisional; Region: PRK11181
405416001218	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032
405416001219	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
405416001220	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
405416001221	EamA-like transporter family; Region: EamA; pfam00892
405416001222	Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237
405416001223	Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022
405416001224	CoA-binding site [chemical binding]; other site
405416001225	ATP-binding [chemical binding]; other site
405416001226	Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989
405416001227	Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750
405416001228	Type IV leader peptidase family; Region: Peptidase_A24; pfam01478
405416001229	Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459
405416001230	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
405416001231	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
405416001232	type IV-A pilus assembly ATPase PilB; Region: type_IV_pilB; TIGR02538
405416001233	Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157
405416001234	PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129
405416001235	Walker A motif; other site
405416001236	ATP binding site [chemical binding]; other site
405416001237	Walker B motif; other site
405416001238	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
405416001239	triosephosphate isomerase; Provisional; Region: PRK14567
405416001240	substrate binding site [chemical binding]; other site
405416001241	dimer interface [polypeptide binding]; other site
405416001242	catalytic triad [active]
405416001243	Preprotein translocase SecG subunit; Region: SecG; pfam03840
405416001244	Sm and related proteins; Region: Sm_like; cl00259
405416001245	ribosome maturation protein RimP; Reviewed; Region: PRK00092
405416001246	Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734
405416001247	putative oligomer interface [polypeptide binding]; other site
405416001248	putative RNA binding site [nucleotide binding]; other site
405416001249	transcription elongation factor NusA; Validated; Region: nusA; PRK09202
405416001250	NusA N-terminal domain; Region: NusA_N; pfam08529
405416001251	S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455
405416001252	RNA binding site [nucleotide binding]; other site
405416001253	homodimer interface [polypeptide binding]; other site
405416001254	NusA-like KH domain; Region: KH_5; pfam13184
405416001255	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
405416001256	G-X-X-G motif; other site
405416001257	transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954
405416001258	transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954
405416001259	translation initiation factor IF-2; Region: IF-2; TIGR00487
405416001260	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
405416001261	Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887
405416001262	G1 box; other site
405416001263	putative GEF interaction site [polypeptide binding]; other site
405416001264	GTP/Mg2+ binding site [chemical binding]; other site
405416001265	Switch I region; other site
405416001266	G2 box; other site
405416001267	G3 box; other site
405416001268	Switch II region; other site
405416001269	G4 box; other site
405416001270	G5 box; other site
405416001271	This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702
405416001272	Translation-initiation factor 2; Region: IF-2; pfam11987
405416001273	mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692
405416001274	ribosome-binding factor A; Provisional; Region: PRK13816
405416001275	putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12674
405416001276	Multiple resistance and pH regulation protein F (MrpF / PhaF); Region: MrpF_PhaF; cl09154
405416001277	putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK08965
405416001278	putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12666
405416001279	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
405416001280	putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK09094
405416001281	putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12648
405416001282	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
405416001283	Domain of unknown function (DUF4040); Region: DUF4040; pfam13244
405416001284	Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111
405416001285	putative monovalent cation/H+ antiporter subunit B; Reviewed; Region: PRK12573
405416001286	AAA domain; Region: AAA_23; pfam13476
405416001287	Family description; Region: UvrD_C_2; pfam13538
405416001288	bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759
405416001289	phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051
405416001290	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534
405416001291	metal binding site [ion binding]; metal-binding site
405416001292	2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654
405416001293	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
405416001294	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
405416001295	ABC1 family; Region: ABC1; cl17513
405416001296	2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982
405416001297	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3165
405416001298	Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226
405416001299	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
405416001300	S-adenosylmethionine binding site [chemical binding]; other site
405416001301	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4627
405416001302	Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971
405416001303	polyphosphate:AMP phosphotransferase; Region: poly_P_AMP_trns; TIGR03708
405416001304	Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971
405416001305	Uncharacterized protein/domain associated with GTPases [Function unknown]; Region: COG3597
405416001306	Exodeoxyribonuclease V, gamma subunit; Region: Exonuc_V_gamma; pfam04257
405416001307	exonuclease V subunit gamma; Provisional; Region: recC; PRK11069
405416001308	Part of AAA domain; Region: AAA_19; pfam13245
405416001309	ATP-dependent exoDNAse (exonuclease V) beta subunit (contains helicase and exonuclease domains) [DNA replication, recombination, and repair]; Region: RecB; COG1074
405416001310	Family description; Region: UvrD_C_2; pfam13538
405416001311	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
405416001312	AAA domain; Region: AAA_30; pfam13604
405416001313	AAA domain; Region: AAA_22; pfam13401
405416001314	Family description; Region: UvrD_C_2; pfam13538
405416001315	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
405416001316	Beta-lactamase; Region: Beta-lactamase; pfam00144
405416001317	Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353
405416001318	16S/18S rRNA binding site [nucleotide binding]; other site
405416001319	S13e-L30e interaction site [polypeptide binding]; other site
405416001320	25S rRNA binding site [nucleotide binding]; other site
405416001321	polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824
405416001322	Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363
405416001323	RNase E interface [polypeptide binding]; other site
405416001324	trimer interface [polypeptide binding]; other site
405416001325	Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726
405416001326	Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364
405416001327	RNase E interface [polypeptide binding]; other site
405416001328	trimer interface [polypeptide binding]; other site
405416001329	active site
405416001330	Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393
405416001331	putative nucleic acid binding region [nucleotide binding]; other site
405416001332	G-X-X-G motif; other site
405416001333	S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase  is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472
405416001334	RNA binding site [nucleotide binding]; other site
405416001335	domain interface; other site
405416001336	CorA-like Mg2+ transporter protein; Region: CorA; pfam01544
405416001337	Thermotoga maritima CorA-like family; Region: TmCorA-like; cd12822
405416001338	oligomer interface [polypeptide binding]; other site
405416001339	metal binding site [ion binding]; metal-binding site
405416001340	metal binding site [ion binding]; metal-binding site
405416001341	putative Cl binding site [ion binding]; other site
405416001342	aspartate ring; other site
405416001343	basic sphincter; other site
405416001344	hydrophobic gate; other site
405416001345	periplasmic entrance; other site
405416001346	MerR HTH family regulatory protein; Region: MerR_2; pfam13591
405416001347	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
405416001348	chaperone protein DnaJ; Region: DnaJ_bact; TIGR02349
405416001349	HSP70 interaction site [polypeptide binding]; other site
405416001350	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
405416001351	substrate binding site [polypeptide binding]; other site
405416001352	dimer interface [polypeptide binding]; other site
405416001353	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
405416001354	Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114
405416001355	Heat shock protein 33 (Hsp33):  Cytosolic protein that acts as a molecular chaperone under oxidative conditions.  In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498
405416001356	dimerization interface [polypeptide binding]; other site
405416001357	domain crossover interface; other site
405416001358	redox-dependent activation switch; other site
405416001359	glutathione-regulated potassium-efflux system protein KefC; Provisional; Region: PRK03562
405416001360	transporter, monovalent cation:proton antiporter-2 (CPA2) family; Region: 2a37; TIGR00932
405416001361	TrkA-N domain; Region: TrkA_N; pfam02254
405416001362	primosome assembly protein PriA; Validated; Region: PRK05580
405416001363	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
405416001364	ATP binding site [chemical binding]; other site
405416001365	putative Mg++ binding site [ion binding]; other site
405416001366	helicase superfamily c-terminal domain; Region: HELICc; smart00490
405416001367	ATP-binding site [chemical binding]; other site
405416001368	type II secretion system protein F; Region: GspF; TIGR02120
405416001369	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
405416001370	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
405416001371	type II secretion system protein G; Region: typeII_sec_gspG; TIGR01710
405416001372	Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334
405416001373	tRNA-binding-domain-containing CsaA-like proteins. CsaA is a molecular chaperone with export related activities. CsaA has a putative tRNA binding activity. The functional unit of CsaA is a homodimer and this domain acts as a dimerization domain; Region: tRNA_bind_CsaA; cd02798
405416001374	dimer interface [polypeptide binding]; other site
405416001375	putative tRNA-binding site [nucleotide binding]; other site
405416001376	apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302
405416001377	Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571
405416001378	putative active site [active]
405416001379	catalytic triad [active]
405416001380	putative dimer interface [polypeptide binding]; other site
405416001381	FOG: CBS domain [General function prediction only]; Region: COG0517
405416001382	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
405416001383	Transporter associated domain; Region: CorC_HlyC; smart01091
405416001384	SirA (also known as UvrY,  and YhhP) belongs to a family of two-component response regulators that controls secondary metabolism and virulence. The other member of this two-component system is a sensor kinase called BarA which phosphorylates SirA.  A...; Region: SirA; cd03423
405416001385	CPxP  motif; other site
405416001386	Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644
405416001387	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
405416001388	Electron transfer flavoprotein-ubiquinone oxidoreductase; Region: ETF_QO; pfam05187
405416001389	Ferredoxin-like protein [Energy production and conversion]; Region: FixX; COG2440
405416001390	Protein of unknown function (DUF1285); Region: DUF1285; pfam06938
405416001391	glutamate racemase; Provisional; Region: PRK00865
405416001392	aspartate racemase; Region: asp_race; TIGR00035
405416001393	Domain of unknown function (DUF4062); Region: DUF4062; pfam13271
405416001394	ferrochelatase; Reviewed; Region: hemH; PRK00035
405416001395	Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411
405416001396	C-terminal domain interface [polypeptide binding]; other site
405416001397	active site
405416001398	Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419
405416001399	active site
405416001400	N-terminal domain interface [polypeptide binding]; other site
405416001401	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
405416001402	Domain of unknown function (DUF329); Region: DUF329; pfam03884
405416001403	Putative methyltransferase; Region: Methyltransf_4; cl17290
405416001404	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
405416001405	uncharacterized flavoprotein, PP_4765 family; Region: flavo_PP4765; TIGR03862
405416001406	Glutathione-dependent formaldehyde-activating enzyme; Region: GFA; pfam04828
405416001407	chromosome condensation membrane protein; Provisional; Region: PRK14196
405416001408	HopJ type III effector protein; Region: HopJ; pfam08888
405416001409	50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678
405416001410	Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661
405416001411	ABC1 family; Region: ABC1; pfam03109
405416001412	sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022
405416001413	Dibenzothiophene (DBT) desulfurization enzyme C; Region: DszC; cd01163
405416001414	Flavin binding site [chemical binding]; other site
405416001415	Dibenzothiophene (DBT) desulfurization enzyme C; Region: DszC; cd01163
405416001416	sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022
405416001417	Flavin binding site [chemical binding]; other site
405416001418	multidrug efflux protein; Reviewed; Region: PRK01766
405416001419	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131
405416001420	cation binding site [ion binding]; other site
405416001421	Protein of unknown function, DUF606; Region: DUF606; pfam04657
405416001422	HemN family oxidoreductase; Provisional; Region: PRK05660
405416001423	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
405416001424	FeS/SAM binding site; other site
405416001425	HemN C-terminal domain; Region: HemN_C; pfam06969
405416001426	short chain dehydrogenase; Provisional; Region: PRK12744
405416001427	tetrahydroxynaphthalene/trihydroxynaphthalene reductase-like, classical (c) SDRs; Region: THN_reductase-like_SDR_c; cd05362
405416001428	NADP binding site [chemical binding]; other site
405416001429	homodimer interface [polypeptide binding]; other site
405416001430	active site
405416001431	substrate binding site [chemical binding]; other site
405416001432	Transcriptional regulator [Transcription]; Region: LysR; COG0583
405416001433	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
405416001434	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472
405416001435	putative effector binding pocket; other site
405416001436	putative dimerization interface [polypeptide binding]; other site
405416001437	long-chain-acyl-CoA synthetase; Validated; Region: PRK08279
405416001438	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
405416001439	Fatty acid transport proteins (FATP) play dual roles as fatty acid transporters and its activation enzymes; Region: FATP_FACS; cd05940
405416001440	acyl-activating enzyme (AAE) consensus motif; other site
405416001441	putative AMP binding site [chemical binding]; other site
405416001442	putative active site [active]
405416001443	putative CoA binding site [chemical binding]; other site
405416001444	Ribonucleases G and E [Translation, ribosomal structure and biogenesis]; Region: CafA; COG1530
405416001445	S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453
405416001446	homodimer interface [polypeptide binding]; other site
405416001447	oligonucleotide binding site [chemical binding]; other site
405416001448	23S rRNA pseudouridylate synthase C; Provisional; Region: PRK11025
405416001449	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
405416001450	RNA binding surface [nucleotide binding]; other site
405416001451	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
405416001452	active site
405416001453	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
405416001454	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
405416001455	motif II; other site
405416001456	Predicted transcriptional regulator [Transcription]; Region: COG2378
405416001457	HTH domain; Region: HTH_11; pfam08279
405416001458	WYL domain; Region: WYL; pfam13280
405416001459	GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972
405416001460	GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046
405416001461	putative C-terminal domain interface [polypeptide binding]; other site
405416001462	putative GSH binding site (G-site) [chemical binding]; other site
405416001463	putative dimer interface [polypeptide binding]; other site
405416001464	C-terminal, alpha helical domain of an unknown subfamily 8 of Glutathione S-transferases; Region: GST_C_8; cd03207
405416001465	dimer interface [polypeptide binding]; other site
405416001466	N-terminal domain interface [polypeptide binding]; other site
405416001467	putative substrate binding pocket (H-site) [chemical binding]; other site
405416001468	Protein of unknown function (DUF1345); Region: DUF1345; pfam07077
405416001469	DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906
405416001470	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
405416001471	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
405416001472	dimerization interface [polypeptide binding]; other site
405416001473	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
405416001474	Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706
405416001475	catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061
405416001476	Heme-dependent peroxidases similar to plant peroxidases; Region: plant_peroxidase_like; cl00196
405416001477	heme binding site [chemical binding]; other site
405416001478	C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200
405416001479	Signal transduction protein containing GAF and PtsI domains [Signal transduction mechanisms]; Region: PtsP; COG3605
405416001480	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
405416001481	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
405416001482	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
405416001483	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
405416001484	Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671
405416001485	putative active site [active]
405416001486	Ap4A binding site [chemical binding]; other site
405416001487	nudix motif; other site
405416001488	putative metal binding site [ion binding]; other site
405416001489	Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560
405416001490	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
405416001491	Transcriptional regulator [Transcription]; Region: LysR; COG0583
405416001492	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
405416001493	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
405416001494	dimerization interface [polypeptide binding]; other site
405416001495	Predicted membrane protein (DUF2061); Region: DUF2061; pfam09834
405416001496	3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402
405416001497	3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583
405416001498	substrate binding site [chemical binding]; other site
405416001499	ligand binding site [chemical binding]; other site
405416001500	isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641
405416001501	Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577
405416001502	substrate binding site [chemical binding]; other site
405416001503	3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772
405416001504	tartrate dehydrogenase; Region: TTC; TIGR02089
405416001505	Protein of unknown function (DUF1311); Region: DUF1311; cl01530
405416001506	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
405416001507	rRNA binding site [nucleotide binding]; other site
405416001508	predicted 30S ribosome binding site; other site
405416001509	Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625
405416001510	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
405416001511	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
405416001512	tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021
405416001513	Eukaryotic and bacterial pseudouridine synthases similar to E.  coli TruA; Region: PseudoU_synth_EcTruA; cd02570
405416001514	dimerization interface 3.5A [polypeptide binding]; other site
405416001515	active site
405416001516	Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963
405416001517	active site
405416001518	homodimer interface [polypeptide binding]; other site
405416001519	FimV N-terminal domain; Region: FimV_core; TIGR03505
405416001520	aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK06598
405416001521	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
405416001522	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
405416001523	putative catalytic site [active]
405416001524	putative metal binding site [ion binding]; other site
405416001525	putative phosphate binding site [ion binding]; other site
405416001526	glutamate/aspartate:proton symporter; Provisional; Region: gltP; PRK11283
405416001527	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
405416001528	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
405416001529	This family is most closely related to the GT1 family of glycosyltransferases. WavL in Vibrio cholerae has been shown to be involved in the biosynthesis of the lipopolysaccharide core; Region: GT1_WavL_like; cd03819
405416001530	putative ADP-binding pocket [chemical binding]; other site
405416001531	Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279
405416001532	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
405416001533	putative acyl-acceptor binding pocket; other site
405416001534	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
405416001535	ABC transporter ATPase component; Reviewed; Region: PRK11147
405416001536	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
405416001537	Walker A/P-loop; other site
405416001538	ATP binding site [chemical binding]; other site
405416001539	Q-loop/lid; other site
405416001540	ABC transporter signature motif; other site
405416001541	Walker B; other site
405416001542	D-loop; other site
405416001543	H-loop/switch region; other site
405416001544	ABC transporter; Region: ABC_tran_2; pfam12848
405416001545	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
405416001546	SlyX; Region: SlyX; pfam04102
405416001547	Arginate lyase and other MDR family members; Region: AL_MDR; cd08252
405416001548	zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817
405416001549	putative NAD(P) binding site [chemical binding]; other site
405416001550	dimer interface [polypeptide binding]; other site
405416001551	Predicted transcriptional regulators [Transcription]; Region: COG1733
405416001552	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
405416001553	Ammonium Transporter Family; Region: Ammonium_transp; cl03012
405416001554	DNA topoisomerase I subunit omega; Validated; Region: PRK07561
405416001555	TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I.   Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363
405416001556	active site
405416001557	interdomain interaction site; other site
405416001558	putative metal-binding site [ion binding]; other site
405416001559	nucleotide binding site [chemical binding]; other site
405416001560	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
405416001561	domain I; other site
405416001562	DNA binding groove [nucleotide binding]
405416001563	phosphate binding site [ion binding]; other site
405416001564	domain II; other site
405416001565	domain III; other site
405416001566	nucleotide binding site [chemical binding]; other site
405416001567	catalytic site [active]
405416001568	domain IV; other site
405416001569	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
405416001570	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
405416001571	Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272
405416001572	Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272
405416001573	Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247
405416001574	Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
405416001575	Part of AAA domain; Region: AAA_19; pfam13245
405416001576	Family description; Region: UvrD_C_2; pfam13538
405416001577	RNA-binding proteins (RRM domain) [General function prediction only]; Region: COG0724
405416001578	RNA recognition motif; Region: RRM; smart00360
405416001579	ASC-1 homology or ASCH domain, a small beta-barrel domain found in all three kingdoms of life. ASCH resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as an RNA-binding domain during coactivation; Region: ASCH; cl01020
405416001580	putative cation:proton antiport protein; Provisional; Region: PRK10669
405416001581	Kef-type K+ transport system, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: RosB; COG4651
405416001582	TrkA-N domain; Region: TrkA_N; pfam02254
405416001583	50S ribosomal protein L33; Validated; Region: rpmG; PRK00595
405416001584	50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359
405416001585	aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381
405416001586	Coniferyl aldehyde dehydrogenase-like; Region: ALDH_CALDH_CalB; cd07133
405416001587	NAD(P) binding site [chemical binding]; other site
405416001588	catalytic residues [active]
405416001589	Bacterial transcriptional repressor; Region: TetR; pfam13972
405416001590	formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027
405416001591	N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875
405416001592	Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648
405416001593	putative active site [active]
405416001594	putative substrate binding site [chemical binding]; other site
405416001595	putative cosubstrate binding site; other site
405416001596	catalytic site [active]
405416001597	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
405416001598	Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811
405416001599	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
405416001600	Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472
405416001601	methionine sulfoxide reductase A; Provisional; Region: PRK14054
405416001602	Domain of unknown function (DUF4105); Region: DUF4105; pfam13387
405416001603	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
405416001604	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209
405416001605	folate binding site [chemical binding]; other site
405416001606	NADP+ binding site [chemical binding]; other site
405416001607	thymidylate synthase; Reviewed; Region: thyA; PRK01827
405416001608	Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351
405416001609	dimerization interface [polypeptide binding]; other site
405416001610	active site
405416001611	prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK12437
405416001612	NRDE protein; Region: NRDE; cl01315
405416001613	Predicted phosphatase [General function prediction only]; Region: PhoX; COG3211
405416001614	Bacterial protein of unknown function (DUF839); Region: DUF839; pfam05787
405416001615	Sec-independent protein translocase protein (TatC); Region: TatC; cl00521
405416001616	twin arginine-targeting protein translocase TatB; Region: tatB; TIGR01410
405416001617	mttA/Hcf106 family; Region: MttA_Hcf106; cl00788
405416001618	Membrane transport protein; Region: Mem_trans; cl09117
405416001619	NTPase/HAM1.  This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515
405416001620	active site
405416001621	dimerization interface [polypeptide binding]; other site
405416001622	Sel1-like repeats; Region: SEL1; smart00671
405416001623	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
405416001624	Sel1-like repeats; Region: SEL1; smart00671
405416001625	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
405416001626	S-adenosylmethionine binding site [chemical binding]; other site
405416001627	homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175
405416001628	homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392
405416001629	2-isopropylmalate synthase; Validated; Region: PRK03739
405416001630	Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942
405416001631	active site
405416001632	catalytic residues [active]
405416001633	metal binding site [ion binding]; metal-binding site
405416001634	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917
405416001635	Fe(II)-dependent oxygenase superfamily protein; Provisional; Region: PRK05467
405416001636	Outer membrane receptor for monomeric catechols [Inorganic ion transport and metabolism]; Region: Fiu; COG4774
405416001637	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
405416001638	N-terminal plug; other site
405416001639	ligand-binding site [chemical binding]; other site
405416001640	trigger factor; Provisional; Region: tig; PRK01490
405416001641	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
405416001642	Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698
405416001643	Clp protease; Region: CLP_protease; pfam00574
405416001644	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
405416001645	oligomer interface [polypeptide binding]; other site
405416001646	active site residues [active]
405416001647	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
405416001648	ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689
405416001649	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
405416001650	Walker A motif; other site
405416001651	ATP binding site [chemical binding]; other site
405416001652	Walker B motif; other site
405416001653	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
405416001654	Protein of unknown function (DUF2846); Region: DUF2846; pfam11008
405416001655	Uncharacterized protein conserved in bacteria (DUF2059); Region: DUF2059; pfam09832
405416001656	Fumarate hydratase (Fumerase); Region: Fumerase; pfam05681
405416001657	Fumarase C-terminus; Region: Fumerase_C; pfam05683
405416001658	phosphate acetyltransferase; Reviewed; Region: PRK05632
405416001659	DRTGG domain; Region: DRTGG; pfam07085
405416001660	phosphotransacetylase; Reviewed; Region: eutD; PRK09653
405416001661	acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180
405416001662	propionate/acetate kinase; Provisional; Region: PRK12379
405416001663	phosphogluconate dehydratase; Validated; Region: PRK09054
405416001664	6-phosphogluconate dehydratase; Region: edd; TIGR01196
405416001665	keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718
405416001666	KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452
405416001667	active site
405416001668	intersubunit interface [polypeptide binding]; other site
405416001669	catalytic residue [active]
405416001670	GntP family permease; Region: GntP_permease; pfam02447
405416001671	fructuronate transporter; Provisional; Region: PRK10034; cl15264
405416001672	Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021
405416001673	ATP-binding site [chemical binding]; other site
405416001674	Gluconate-6-phosphate binding site [chemical binding]; other site
405416001675	Shikimate kinase; Region: SKI; pfam01202
405416001676	NADP+-dependent non-phosphorylating glyceraldehyde 3-phosphate dehydrogenase and ALDH family 11; Region: ALDH_F11_NP-GAPDH; cd07082
405416001677	NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012
405416001678	tetrameric interface [polypeptide binding]; other site
405416001679	activator binding site; other site
405416001680	NADP binding site [chemical binding]; other site
405416001681	substrate binding site [chemical binding]; other site
405416001682	catalytic residues [active]
405416001683	Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079
405416001684	gamma-glutamyl phosphate reductase; Region: proA; TIGR00407
405416001685	putative catalytic cysteine [active]
405416001686	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
405416001687	Leucine carboxyl methyltransferase; Region: LCM; pfam04072
405416001688	beta-hexosaminidase; Provisional; Region: PRK05337
405416001689	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
405416001690	carboxy-terminal protease; Provisional; Region: PRK11186
405416001691	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
405416001692	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
405416001693	protein binding site [polypeptide binding]; other site
405416001694	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
405416001695	Catalytic dyad [active]
405416001696	C-terminal domain of tail specific protease (DUF3340); Region: DUF3340; pfam11818
405416001697	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
405416001698	This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814
405416001699	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
405416001700	PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610
405416001701	active site
405416001702	Iron-sulphur cluster assembly; Region: Fe-S_assembly; pfam04384
405416001703	Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413
405416001704	active site
405416001705	multimer interface [polypeptide binding]; other site
405416001706	ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK11194
405416001707	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
405416001708	FeS/SAM binding site; other site
405416001709	type IV pilus biogenesis/stability protein PilW; Region: type_IV_pilW; TIGR02521
405416001710	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
405416001711	TPR motif; other site
405416001712	binding surface
405416001713	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
405416001714	TPR motif; other site
405416001715	binding surface
405416001716	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
405416001717	binding surface
405416001718	TPR motif; other site
405416001719	Helix-turn-helix domain; Region: HTH_25; pfam13413
405416001720	Domain of unknown function (DUF4115); Region: DUF4115; pfam13464
405416001721	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366
405416001722	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
405416001723	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
405416001724	histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037
405416001725	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
405416001726	dimer interface [polypeptide binding]; other site
405416001727	motif 1; other site
405416001728	active site
405416001729	motif 2; other site
405416001730	motif 3; other site
405416001731	HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859
405416001732	anticodon binding site; other site
405416001733	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2976
405416001734	Uncharacterized protein conserved in bacteria (DUF2133); Region: DUF2133; pfam09976
405416001735	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
405416001736	TPR motif; other site
405416001737	binding surface
405416001738	outer membrane assembly lipoprotein YfgL; Region: assembly_YfgL; TIGR03300
405416001739	PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493
405416001740	Trp docking motif [polypeptide binding]; other site
405416001741	active site
405416001742	GTP-binding protein Der; Reviewed; Region: PRK00093
405416001743	EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894
405416001744	G1 box; other site
405416001745	GTP/Mg2+ binding site [chemical binding]; other site
405416001746	Switch I region; other site
405416001747	G2 box; other site
405416001748	Switch II region; other site
405416001749	G3 box; other site
405416001750	G4 box; other site
405416001751	G5 box; other site
405416001752	EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895
405416001753	G1 box; other site
405416001754	GTP/Mg2+ binding site [chemical binding]; other site
405416001755	Switch I region; other site
405416001756	G2 box; other site
405416001757	G3 box; other site
405416001758	Switch II region; other site
405416001759	G4 box; other site
405416001760	G5 box; other site
405416001761	Beta-ketoacyl synthase, N-terminal domain; Region: Ketoacyl-synt_2; pfam13723
405416001762	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
405416001763	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
405416001764	putative acyl-acceptor binding pocket; other site
405416001765	Phosphopantetheine attachment site; Region: PP-binding; cl09936
405416001766	acyl carrier protein; Provisional; Region: PRK05350
405416001767	Predicted membrane protein [Function unknown]; Region: COG4648
405416001768	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
405416001769	Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365
405416001770	acyl-activating enzyme (AAE) consensus motif; other site
405416001771	active site
405416001772	AMP binding site [chemical binding]; other site
405416001773	CoA binding site [chemical binding]; other site
405416001774	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
405416001775	active site 2 [active]
405416001776	active site 1 [active]
405416001777	DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179
405416001778	Ligand binding site; other site
405416001779	Putative Catalytic site; other site
405416001780	DXD motif; other site
405416001781	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
405416001782	putative acyl-acceptor binding pocket; other site
405416001783	Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332
405416001784	active sites [active]
405416001785	tetramer interface [polypeptide binding]; other site
405416001786	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
405416001787	active site
405416001788	Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl17548
405416001789	Predicted exporter [General function prediction only]; Region: COG4258
405416001790	Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644
405416001791	3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK09185
405416001792	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
405416001793	dimer interface [polypeptide binding]; other site
405416001794	active site
405416001795	Domain of unknown function, appears to be related to a diverse group of beta-hydroxydecanoyl ACP dehydratases (FabA) and beta-hydroxyacyl ACP dehydratases (FabZ). This group appears to lack the conserved active site histidine of FabA and FabZ; Region: FabA_like; cd01289
405416001796	putative active site 1 [active]
405416001797	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
405416001798	3-oxoacyl-(acyl-carrier-protein) reductase, putative; Region: fabG_rel; TIGR01831
405416001799	NAD(P) binding site [chemical binding]; other site
405416001800	homotetramer interface [polypeptide binding]; other site
405416001801	homodimer interface [polypeptide binding]; other site
405416001802	active site
405416001803	3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK09116
405416001804	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
405416001805	dimer interface [polypeptide binding]; other site
405416001806	active site
405416001807	Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091
405416001808	4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648
405416001809	preprotein translocase subunit SecB; Validated; Region: PRK05751
405416001810	SecA binding site; other site
405416001811	Preprotein binding site; other site
405416001812	Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418
405416001813	GSH binding site [chemical binding]; other site
405416001814	catalytic residues [active]
405416001815	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
405416001816	active site residue [active]
405416001817	GTPase RsgA; Reviewed; Region: PRK12288
405416001818	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
405416001819	RNA binding site [nucleotide binding]; other site
405416001820	Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854
405416001821	GTPase/Zn-binding domain interface [polypeptide binding]; other site
405416001822	GTP/Mg2+ binding site [chemical binding]; other site
405416001823	G4 box; other site
405416001824	G5 box; other site
405416001825	G1 box; other site
405416001826	Switch I region; other site
405416001827	G2 box; other site
405416001828	G3 box; other site
405416001829	Switch II region; other site
405416001830	DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135
405416001831	putative active site [active]
405416001832	putative substrate binding site [chemical binding]; other site
405416001833	dimer interface [polypeptide binding]; other site
405416001834	catalytic site [active]
405416001835	Bax inhibitor 1 like; Region: BaxI_1; cl17691
405416001836	Enoyl-[acyl-carrier-protein]; Region: FabI; COG0623
405416001837	Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372
405416001838	NAD binding site [chemical binding]; other site
405416001839	homotetramer interface [polypeptide binding]; other site
405416001840	homodimer interface [polypeptide binding]; other site
405416001841	substrate binding site [chemical binding]; other site
405416001842	active site
405416001843	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
405416001844	macrolide transporter ATP-binding /permease protein; Provisional; Region: PRK10535
405416001845	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
405416001846	Walker A/P-loop; other site
405416001847	ATP binding site [chemical binding]; other site
405416001848	Q-loop/lid; other site
405416001849	ABC transporter signature motif; other site
405416001850	Walker B; other site
405416001851	D-loop; other site
405416001852	H-loop/switch region; other site
405416001853	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
405416001854	FtsX-like permease family; Region: FtsX; pfam02687
405416001855	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
405416001856	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
405416001857	HlyD family secretion protein; Region: HlyD_3; pfam13437
405416001858	DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574
405416001859	DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144
405416001860	Lipopolysaccharide-assembly; Region: LptE; pfam04390
405416001861	leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390
405416001862	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
405416001863	HIGH motif; other site
405416001864	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
405416001865	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
405416001866	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
405416001867	active site
405416001868	KMSKS motif; other site
405416001869	Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958
405416001870	tRNA binding surface [nucleotide binding]; other site
405416001871	Domain of unknown function (DUF4124); Region: DUF4124; pfam13511
405416001872	acetolactate synthase 3 catalytic subunit; Validated; Region: PRK06466
405416001873	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
405416001874	PYR/PP interface [polypeptide binding]; other site
405416001875	dimer interface [polypeptide binding]; other site
405416001876	TPP binding site [chemical binding]; other site
405416001877	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
405416001878	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
405416001879	TPP-binding site [chemical binding]; other site
405416001880	dimer interface [polypeptide binding]; other site
405416001881	acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895
405416001882	N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878
405416001883	putative valine binding site [chemical binding]; other site
405416001884	dimer interface [polypeptide binding]; other site
405416001885	Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369
405416001886	ketol-acid reductoisomerase; Provisional; Region: PRK05479
405416001887	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991
405416001888	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450
405416001889	MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300
405416001890	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
405416001891	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
405416001892	metal binding site [ion binding]; metal-binding site
405416001893	active site
405416001894	I-site; other site
405416001895	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
405416001896	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
405416001897	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
405416001898	transcriptional repressor BetI; Region: betaine_BetI; TIGR03384
405416001899	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
405416001900	peptide chain release factor 3; Provisional; Region: prfC; PRK00741
405416001901	Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169
405416001902	G1 box; other site
405416001903	putative GEF interaction site [polypeptide binding]; other site
405416001904	GTP/Mg2+ binding site [chemical binding]; other site
405416001905	Switch I region; other site
405416001906	G2 box; other site
405416001907	G3 box; other site
405416001908	Switch II region; other site
405416001909	G4 box; other site
405416001910	G5 box; other site
405416001911	RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689
405416001912	Protein of unknown function (DUF3298); Region: DUF3298; pfam11738
405416001913	Domain of unknown function (DUF4163); Region: DUF4163; pfam13739
405416001914	Protein of unknown function (DUF3298); Region: DUF3298; pfam11738
405416001915	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
405416001916	active site
405416001917	aconitate hydratase; Validated; Region: PRK09277
405416001918	Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285
405416001919	substrate binding site [chemical binding]; other site
405416001920	ligand binding site [chemical binding]; other site
405416001921	Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580
405416001922	substrate binding site [chemical binding]; other site
405416001923	This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function.  The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199
405416001924	homotrimer interaction site [polypeptide binding]; other site
405416001925	putative active site [active]
405416001926	Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179
405416001927	Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755
405416001928	putative ATP binding site [chemical binding]; other site
405416001929	putative substrate interface [chemical binding]; other site
405416001930	Transcriptional regulator [Transcription]; Region: LysR; COG0583
405416001931	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
405416001932	The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414
405416001933	dimerization interface [polypeptide binding]; other site
405416001934	substrate binding pocket [chemical binding]; other site
405416001935	tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815
405416001936	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
405416001937	FMN binding site [chemical binding]; other site
405416001938	active site
405416001939	catalytic residues [active]
405416001940	substrate binding site [chemical binding]; other site
405416001941	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
405416001942	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
405416001943	putative substrate translocation pore; other site
405416001944	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
405416001945	homotrimer interaction site [polypeptide binding]; other site
405416001946	putative active site [active]
405416001947	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
405416001948	EamA-like transporter family; Region: EamA; pfam00892
405416001949	EamA-like transporter family; Region: EamA; pfam00892
405416001950	Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304
405416001951	NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288
405416001952	ligand binding site [chemical binding]; other site
405416001953	homodimer interface [polypeptide binding]; other site
405416001954	NAD(P) binding site [chemical binding]; other site
405416001955	trimer interface B [polypeptide binding]; other site
405416001956	trimer interface A [polypeptide binding]; other site
405416001957	Domain of unknown function (DUF3814); Region: DUF3814; pfam12769
405416001958	NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233
405416001959	NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; COG1282
405416001960	retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327
405416001961	acetoacetyl-CoA reductase; Provisional; Region: PRK12935
405416001962	putative NAD(P) binding site [chemical binding]; other site
405416001963	active site
405416001964	iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090
405416001965	hydroxypyruvate isomerase; Region: OH-pyruv-isom; TIGR03234
405416001966	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
405416001967	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
405416001968	enoyl-CoA hydratase; Provisional; Region: PRK07509
405416001969	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
405416001970	substrate binding site [chemical binding]; other site
405416001971	oxyanion hole (OAH) forming residues; other site
405416001972	trimer interface [polypeptide binding]; other site
405416001973	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
405416001974	dimer interface [polypeptide binding]; other site
405416001975	phosphorylation site [posttranslational modification]
405416001976	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
405416001977	ATP binding site [chemical binding]; other site
405416001978	Mg2+ binding site [ion binding]; other site
405416001979	G-X-G motif; other site
405416001980	Response regulator receiver domain; Region: Response_reg; pfam00072
405416001981	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
405416001982	active site
405416001983	phosphorylation site [posttranslational modification]
405416001984	intermolecular recognition site; other site
405416001985	dimerization interface [polypeptide binding]; other site
405416001986	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086
405416001987	cysteine synthase B; Region: cysM; TIGR01138
405416001988	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
405416001989	dimer interface [polypeptide binding]; other site
405416001990	pyridoxal 5'-phosphate binding site [chemical binding]; other site
405416001991	catalytic residue [active]
405416001992	Uncharacterized bacterial subgroup of the DEDDy 3'-5' exonuclease domain of family-B DNA polymerases; Region: DNA_polB_like1_exo; cd05782
405416001993	active site
405416001994	catalytic site [active]
405416001995	substrate binding site [chemical binding]; other site
405416001996	Predicted 3'-5' exonuclease related to the exonuclease domain of PolB; Region: DNA_pol_B_exo2; pfam10108
405416001997	23S rRNA m(5)U1939 methyltransferase; Reviewed; Region: rumA; PRK13168
405416001998	TRAM domain; Region: TRAM; pfam01938
405416001999	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
405416002000	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
405416002001	S-adenosylmethionine binding site [chemical binding]; other site
405416002002	HD domain; Region: HD_4; pfam13328
405416002003	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
405416002004	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
405416002005	synthetase active site [active]
405416002006	NTP binding site [chemical binding]; other site
405416002007	metal binding site [ion binding]; metal-binding site
405416002008	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
405416002009	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
405416002010	short chain dehydrogenase; Provisional; Region: PRK08267
405416002011	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
405416002012	NAD(P) binding site [chemical binding]; other site
405416002013	active site
405416002014	nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562
405416002015	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528
405416002016	homodimer interface [polypeptide binding]; other site
405416002017	metal binding site [ion binding]; metal-binding site
405416002018	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529
405416002019	homodimer interface [polypeptide binding]; other site
405416002020	active site
405416002021	putative chemical substrate binding site [chemical binding]; other site
405416002022	metal binding site [ion binding]; metal-binding site
405416002023	DNA uptake protein and related DNA-binding proteins [DNA replication, recombination, and repair]; Region: ComEA; COG1555
405416002024	Helix-hairpin-helix motif; Region: HHH; pfam00633
405416002025	poly(A) polymerase; Region: pcnB; TIGR01942
405416002026	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
405416002027	active site
405416002028	NTP binding site [chemical binding]; other site
405416002029	metal binding triad [ion binding]; metal-binding site
405416002030	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
405416002031	Polymerase A arginine-rich C-terminus; Region: PolyA_pol_arg_C; pfam12626
405416002032	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483
405416002033	catalytic center binding site [active]
405416002034	ATP binding site [chemical binding]; other site
405416002035	Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557
405416002036	oligomerization interface [polypeptide binding]; other site
405416002037	active site
405416002038	metal binding site [ion binding]; metal-binding site
405416002039	pantoate--beta-alanine ligase; Region: panC; TIGR00018
405416002040	Pantoate-beta-alanine ligase; Region: PanC; cd00560
405416002041	active site
405416002042	ATP-binding site [chemical binding]; other site
405416002043	pantoate-binding site; other site
405416002044	HXXH motif; other site
405416002045	glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416
405416002046	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
405416002047	dimerization domain swap beta strand [polypeptide binding]; other site
405416002048	regulatory protein interface [polypeptide binding]; other site
405416002049	active site
405416002050	regulatory phosphorylation site [posttranslational modification]; other site
405416002051	hypothetical protein; Provisional; Region: PRK05255
405416002052	acyl-CoA synthetase; Validated; Region: PRK08162
405416002053	Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles and Arabidopsis; Region: ttLC_FACS_AEE21_like; cd12118
405416002054	acyl-activating enzyme (AAE) consensus motif; other site
405416002055	putative active site [active]
405416002056	AMP binding site [chemical binding]; other site
405416002057	putative CoA binding site [chemical binding]; other site
405416002058	threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413
405416002059	TGS _ThrRS_N:  ThrRS (threonyl-tRNA Synthetase)  is a class II tRNA synthetase that couples threonine to its cognate tRNA.  In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667
405416002060	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
405416002061	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
405416002062	active site
405416002063	dimer interface [polypeptide binding]; other site
405416002064	motif 1; other site
405416002065	motif 2; other site
405416002066	motif 3; other site
405416002067	ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860
405416002068	anticodon binding site; other site
405416002069	translation initiation factor IF-3; Reviewed; Region: infC; PRK00028
405416002070	Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707
405416002071	GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972
405416002072	GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048
405416002073	C-terminal domain interface [polypeptide binding]; other site
405416002074	GSH binding site (G-site) [chemical binding]; other site
405416002075	dimer interface [polypeptide binding]; other site
405416002076	C-terminal, alpha helical domain of Escherichia coli YfcG Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YfcG_like; cd10291
405416002077	N-terminal domain interface [polypeptide binding]; other site
405416002078	putative dimer interface [polypeptide binding]; other site
405416002079	active site
405416002080	Predicted membrane protein [Function unknown]; Region: COG1238
405416002081	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
405416002082	putative substrate translocation pore; other site
405416002083	H+ Antiporter protein; Region: 2A0121; TIGR00900
405416002084	50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172
405416002085	Ribosomal protein L20; Region: Ribosomal_L20; cd07026
405416002086	23S rRNA binding site [nucleotide binding]; other site
405416002087	L21 binding site [polypeptide binding]; other site
405416002088	L13 binding site [polypeptide binding]; other site
405416002089	Domain of unknown function (DUF1768); Region: DUF1768; pfam08719
405416002090	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
405416002091	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
405416002092	Coenzyme A binding pocket [chemical binding]; other site
405416002093	phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488
405416002094	Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912
405416002095	Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496
405416002096	dimer interface [polypeptide binding]; other site
405416002097	motif 1; other site
405416002098	active site
405416002099	motif 2; other site
405416002100	motif 3; other site
405416002101	phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629
405416002102	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
405416002103	putative tRNA-binding site [nucleotide binding]; other site
405416002104	B3/4 domain; Region: B3_4; pfam03483
405416002105	tRNA synthetase B5 domain; Region: B5; smart00874
405416002106	Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA,  PheRS is an...; Region: PheRS_beta_core; cd00769
405416002107	dimer interface [polypeptide binding]; other site
405416002108	motif 1; other site
405416002109	motif 3; other site
405416002110	motif 2; other site
405416002111	Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147
405416002112	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
405416002113	IHF dimer interface [polypeptide binding]; other site
405416002114	IHF - DNA interface [nucleotide binding]; other site
405416002115	transcription termination factor Rho; Provisional; Region: rho; PRK09376
405416002116	Rho termination factor, N-terminal domain; Region: Rho_N; smart00959
405416002117	Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459
405416002118	RNA binding site [nucleotide binding]; other site
405416002119	Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128
405416002120	multimer interface [polypeptide binding]; other site
405416002121	Walker A motif; other site
405416002122	ATP binding site [chemical binding]; other site
405416002123	Walker B motif; other site
405416002124	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
405416002125	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
405416002126	catalytic residues [active]
405416002127	guanosine pentaphosphate phosphohydrolase; Provisional; Region: PRK11031
405416002128	Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541
405416002129	acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724
405416002130	tRNA(Ile)-lysidine synthetase; Provisional; Region: tilS; PRK10660
405416002131	N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992
405416002132	TilS substrate binding domain; Region: TilS; pfam09179
405416002133	TilS substrate C-terminal domain; Region: TilS_C; pfam11734
405416002134	pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880
405416002135	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232
405416002136	YGGT family; Region: YGGT; pfam02325
405416002137	DNA polymerase I; Provisional; Region: PRK05755
405416002138	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
405416002139	active site
405416002140	metal binding site 1 [ion binding]; metal-binding site
405416002141	putative 5' ssDNA interaction site; other site
405416002142	metal binding site 3; metal-binding site
405416002143	metal binding site 2 [ion binding]; metal-binding site
405416002144	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
405416002145	putative DNA binding site [nucleotide binding]; other site
405416002146	putative metal binding site [ion binding]; other site
405416002147	DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139
405416002148	active site
405416002149	catalytic site [active]
405416002150	substrate binding site [chemical binding]; other site
405416002151	Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637
405416002152	active site
405416002153	DNA binding site [nucleotide binding]
405416002154	catalytic site [active]
405416002155	Predicted membrane protein (DUF2339); Region: DUF2339; pfam10101
405416002156	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
405416002157	Mechanosensitive ion channel; Region: MS_channel; pfam00924
405416002158	Protein of unknown function (DUF432); Region: DUF432; cl01027
405416002159	type II secretion system protein E; Region: type_II_gspE; TIGR02533
405416002160	PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129
405416002161	Walker A motif; other site
405416002162	ATP binding site [chemical binding]; other site
405416002163	Walker B motif; other site
405416002164	peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561
405416002165	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
405416002166	MarR family; Region: MarR; pfam01047
405416002167	Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases); Region: nit; cd07572
405416002168	nitrilase; Region: PLN02798
405416002169	putative active site [active]
405416002170	catalytic triad [active]
405416002171	dimer interface [polypeptide binding]; other site
405416002172	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
405416002173	anti sigma factor interaction site; other site
405416002174	regulatory phosphorylation site [posttranslational modification]; other site
405416002175	Sigma factor PP2C-like phosphatases; Region: PP2C_SIG; smart00331
405416002176	VacJ like lipoprotein; Region: VacJ; cl01073
405416002177	RNA polymerase factor sigma-54; Reviewed; Region: PRK05932
405416002178	Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309
405416002179	Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963
405416002180	Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552
405416002181	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552
405416002182	30S subunit binding site; other site
405416002183	BolA-like protein; Region: BolA; cl00386
405416002184	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
405416002185	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
405416002186	hinge; other site
405416002187	active site
405416002188	ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040
405416002189	ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686
405416002190	Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572
405416002191	histidinol dehydrogenase; Region: hisD; TIGR00069
405416002192	NAD binding site [chemical binding]; other site
405416002193	dimerization interface [polypeptide binding]; other site
405416002194	product binding site; other site
405416002195	substrate binding site [chemical binding]; other site
405416002196	zinc binding site [ion binding]; other site
405416002197	catalytic residues [active]
405416002198	Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079
405416002199	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
405416002200	pyridoxal 5'-phosphate binding site [chemical binding]; other site
405416002201	homodimer interface [polypeptide binding]; other site
405416002202	catalytic residue [active]
405416002203	Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147
405416002204	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
405416002205	A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39G; cd02423
405416002206	putative active site [active]
405416002207	Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; cl17479
405416002208	NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297
405416002209	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_4; cd04511
405416002210	nudix motif; other site
405416002211	Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426
405416002212	putative active site [active]
405416002213	putative CoA binding site [chemical binding]; other site
405416002214	nudix motif; other site
405416002215	metal binding site [ion binding]; metal-binding site
405416002216	Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663
405416002217	Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645
405416002218	trimer interface [polypeptide binding]; other site
405416002219	putative metal binding site [ion binding]; other site
405416002220	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
405416002221	Glycoprotease family; Region: Peptidase_M22; pfam00814
405416002222	Putative SAM-dependent methyltransferase; Region: SAM_MT; cl17517
405416002223	Peptidase C13 family; Region: Peptidase_C13; pfam01650
405416002224	S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821
405416002225	S-formylglutathione hydrolase; Region: PLN02442
405416002226	Uncharacterized protein conserved in bacteria (DUF2218); Region: DUF2218; pfam09981
405416002227	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
405416002228	ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163
405416002229	substrate binding site [chemical binding]; other site
405416002230	hexamer interface [polypeptide binding]; other site
405416002231	metal binding site [ion binding]; metal-binding site
405416002232	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
405416002233	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
405416002234	active site
405416002235	motif I; other site
405416002236	motif II; other site
405416002237	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
405416002238	copper-resistance protein, CopA family; Region: copper_res_A; TIGR01480
405416002239	Multicopper oxidase; Region: Cu-oxidase_3; pfam07732
405416002240	Multicopper oxidase; Region: Cu-oxidase; pfam00394
405416002241	Multicopper oxidase; Region: Cu-oxidase_2; pfam07731
405416002242	Copper resistance protein B precursor (CopB); Region: CopB; pfam05275
405416002243	Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230
405416002244	Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076
405416002245	6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870
405416002246	methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901
405416002247	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
405416002248	DNA binding site [nucleotide binding]
405416002249	active site
405416002250	Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152
405416002251	heterotetramer interface [polypeptide binding]; other site
405416002252	active site pocket [active]
405416002253	cleavage site
405416002254	quinolinate synthetase; Provisional; Region: PRK09375
405416002255	Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816
405416002256	Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320
405416002257	active site
405416002258	purine riboside binding site [chemical binding]; other site
405416002259	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
405416002260	Alcohol dehydrogenases of the MDR family; Region: Zn_ADH8; cd08262
405416002261	putative NAD(P) binding site [chemical binding]; other site
405416002262	catalytic Zn binding site [ion binding]; other site
405416002263	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
405416002264	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
405416002265	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
405416002266	dimerization interface [polypeptide binding]; other site
405416002267	Glutaryl-CoA dehydrogenase; Region: GCD; cd01151
405416002268	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
405416002269	FAD binding site [chemical binding]; other site
405416002270	substrate binding pocket [chemical binding]; other site
405416002271	catalytic base [active]
405416002272	benzoate transport; Region: 2A0115; TIGR00895
405416002273	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
405416002274	putative substrate translocation pore; other site
405416002275	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
405416002276	nitrobindin heme-binding domain; Region: nitrobindin; cl10502
405416002277	CoA-transferase family III; Region: CoA_transf_3; pfam02515
405416002278	tricarballylate utilization protein B; Provisional; Region: PRK15033
405416002279	tricarballylate dehydrogenase; Validated; Region: PRK08274
405416002280	Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730
405416002281	nitrogen assimilation transcriptional regulator; Provisional; Region: PRK11233
405416002282	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
405416002283	The C-teminal substrate binding domain of LysR-like nitrogen assimilation control (NAC) protein, contains the type 2 periplasmic binding fold; Region: PBP2_Nac; cd08433
405416002284	putative dimerization interface [polypeptide binding]; other site
405416002285	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
405416002286	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
405416002287	citrate-proton symporter; Provisional; Region: PRK15075
405416002288	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
405416002289	putative substrate translocation pore; other site
405416002290	Transcriptional regulator [Transcription]; Region: LysR; COG0583
405416002291	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
405416002292	The C-teminal substrate binding domain of LysR-like nitrogen assimilation control (NAC) protein, contains the type 2 periplasmic binding fold; Region: PBP2_Nac; cd08433
405416002293	putative dimerization interface [polypeptide binding]; other site
405416002294	Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; cl17479
405416002295	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
405416002296	M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like6; cd05664
405416002297	metal binding site [ion binding]; metal-binding site
405416002298	putative dimer interface [polypeptide binding]; other site
405416002299	Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625
405416002300	SurA N-terminal domain; Region: SurA_N; pfam09312
405416002301	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
405416002302	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
405416002303	Fatty acid desaturase; Region: FA_desaturase; pfam00487
405416002304	LysE type translocator; Region: LysE; cl00565
405416002305	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
405416002306	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
405416002307	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
405416002308	dimerization interface [polypeptide binding]; other site
405416002309	Domain of unknown function (DUF1852); Region: DUF1852; pfam08908
405416002310	methionine synthase; Provisional; Region: PRK01207
405416002311	CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311
405416002312	substrate binding site [chemical binding]; other site
405416002313	THF binding site; other site
405416002314	zinc-binding site [ion binding]; other site
405416002315	Flavin Reductases; Region: FlaRed; cl00801
405416002316	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
405416002317	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
405416002318	Restriction endonuclease; Region: Mrr_cat; pfam04471
405416002319	AAA ATPase domain; Region: AAA_16; pfam13191
405416002320	AAA domain; Region: AAA_22; pfam13401
405416002321	Transcriptional regulator [Transcription]; Region: LysR; COG0583
405416002322	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
405416002323	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
405416002324	dimerization interface [polypeptide binding]; other site
405416002325	hypothetical protein; Provisional; Region: PRK10281
405416002326	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
405416002327	Helix-turn-helix domain; Region: HTH_38; pfam13936
405416002328	Homeodomain-like domain; Region: HTH_32; pfam13565
405416002329	Integrase core domain; Region: rve; pfam00665
405416002330	Integrase core domain; Region: rve_3; cl15866
405416002331	membrane-bound PQQ-dependent dehydrogenase, glucose/quinate/shikimate family; Region: PQQ_membr_DH; TIGR03074
405416002332	Membrane-bound PQQ-dependent glucose dehydrogenase; Region: PQQ_mGDH; cd10280
405416002333	Trp docking motif [polypeptide binding]; other site
405416002334	putative active site [active]
405416002335	Helix-turn-helix domain; Region: HTH_17; pfam12728
405416002336	Helix-turn-helix domain; Region: HTH_17; pfam12728
405416002337	Bacterial TniB protein; Region: TniB; pfam05621
405416002338	AAA domain; Region: AAA_22; pfam13401
405416002339	Integrase core domain; Region: rve; pfam00665
405416002340	TnsA endonuclease N terminal; Region: Tn7_Tnp_TnsA_N; pfam08722
405416002341	phage-associated protein, BcepMu gp16 family; Region: BcepMu_gp16; TIGR04111
405416002342	Protein of unknown function (DUF4007); Region: DUF4007; pfam13182
405416002343	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
405416002344	Active Sites [active]
405416002345	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
405416002346	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c_3; pfam13589
405416002347	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
405416002348	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
405416002349	ATP binding site [chemical binding]; other site
405416002350	Mg2+ binding site [ion binding]; other site
405416002351	G-X-G motif; other site
405416002352	Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049
405416002353	dimer interface [polypeptide binding]; other site
405416002354	putative radical transfer pathway; other site
405416002355	diiron center [ion binding]; other site
405416002356	tyrosyl radical; other site
405416002357	ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07207
405416002358	ATP cone domain; Region: ATP-cone; pfam03477
405416002359	Class I ribonucleotide reductase; Region: RNR_I; cd01679
405416002360	active site
405416002361	dimer interface [polypeptide binding]; other site
405416002362	catalytic residues [active]
405416002363	effector binding site; other site
405416002364	R2 peptide binding site; other site
405416002365	DNA-binding transcriptional regulator RstA; Provisional; Region: PRK10701
405416002366	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
405416002367	active site
405416002368	phosphorylation site [posttranslational modification]
405416002369	intermolecular recognition site; other site
405416002370	dimerization interface [polypeptide binding]; other site
405416002371	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
405416002372	DNA binding site [nucleotide binding]
405416002373	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
405416002374	dimerization interface [polypeptide binding]; other site
405416002375	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
405416002376	dimer interface [polypeptide binding]; other site
405416002377	phosphorylation site [posttranslational modification]
405416002378	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
405416002379	ATP binding site [chemical binding]; other site
405416002380	Mg2+ binding site [ion binding]; other site
405416002381	G-X-G motif; other site
405416002382	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
405416002383	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
405416002384	metal binding site [ion binding]; metal-binding site
405416002385	active site
405416002386	I-site; other site
405416002387	NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602
405416002388	NADH dehydrogenase subunit B; Validated; Region: PRK06411
405416002389	bifunctional NADH:ubiquinone oxidoreductase subunit C/D; Provisional; Region: PRK11742
405416002390	NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961
405416002391	NADH dehydrogenase subunit D; Validated; Region: PRK06075
405416002392	NADH dehydrogenase subunit E; Validated; Region: PRK07539
405416002393	TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064
405416002394	putative dimer interface [polypeptide binding]; other site
405416002395	[2Fe-2S] cluster binding site [ion binding]; other site
405416002396	NADH dehydrogenase I subunit F; Provisional; Region: PRK11278
405416002397	SLBB domain; Region: SLBB; pfam10531
405416002398	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928
405416002399	NADH dehydrogenase subunit G; Validated; Region: PRK08166
405416002400	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
405416002401	catalytic loop [active]
405416002402	iron binding site [ion binding]; other site
405416002403	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588
405416002404	MopB_NDH-1_NuoG2-N7: The second domain of the NuoG subunit (with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex in the respiratory...; Region: MopB_NDH-1_NuoG2-N7; cd02771
405416002405	[4Fe-4S] binding site [ion binding]; other site
405416002406	MopB_CT_NDH-1_NuoG2-N7: C-terminal region of the NuoG-like subunit (of the variant with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex...; Region: MopB_CT_NDH-1_NuoG2-N7; cd02788
405416002407	NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076
405416002408	Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650
405416002409	NADH-quinone oxidoreductase, chain I; Region: NuoI; TIGR01971
405416002410	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
405416002411	NADH:ubiquinone oxidoreductase subunit 6 (chain J) [Energy production and conversion]; Region: NuoJ; COG0839
405416002412	NADH dehydrogenase subunit J; Provisional; Region: PRK06433
405416002413	NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715
405416002414	NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590
405416002415	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662
405416002416	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
405416002417	NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846
405416002418	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
405416002419	NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777
405416002420	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
405416002421	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
405416002422	active site
405416002423	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
405416002424	DNA-binding site [nucleotide binding]; DNA binding site
405416002425	RNA-binding motif; other site
405416002426	putative DNA-binding transcriptional regulator; Provisional; Region: PRK10837
405416002427	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
405416002428	C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420
405416002429	putative dimerization interface [polypeptide binding]; other site
405416002430	ferredoxin-NADP reductase; Provisional; Region: PRK10926
405416002431	Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195
405416002432	FAD binding pocket [chemical binding]; other site
405416002433	FAD binding motif [chemical binding]; other site
405416002434	phosphate binding motif [ion binding]; other site
405416002435	beta-alpha-beta structure motif; other site
405416002436	NAD binding pocket [chemical binding]; other site
405416002437	Conserved TM helix; Region: TM_helix; pfam05552
405416002438	Conserved TM helix; Region: TM_helix; pfam05552
405416002439	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
405416002440	Conserved TM helix; Region: TM_helix; pfam05552
405416002441	Conserved TM helix; Region: TM_helix; pfam05552
405416002442	HI0933-like protein; Region: HI0933_like; pfam03486
405416002443	Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342
405416002444	Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291
405416002445	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
405416002446	catalytic residue [active]
405416002447	efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998
405416002448	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
405416002449	HlyD family secretion protein; Region: HlyD_3; pfam13437
405416002450	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
405416002451	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
405416002452	putative substrate translocation pore; other site
405416002453	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
405416002454	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
405416002455	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
405416002456	methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133
405416002457	catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814
405416002458	active site
405416002459	HIGH motif; other site
405416002460	KMSKS motif; other site
405416002461	Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957
405416002462	tRNA binding surface [nucleotide binding]; other site
405416002463	anticodon binding site; other site
405416002464	tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins.  This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties.  MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800
405416002465	dimer interface [polypeptide binding]; other site
405416002466	putative tRNA-binding site [nucleotide binding]; other site
405416002467	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489
405416002468	MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037
405416002469	Phosphorylase superfamily; Region: PNP_UDP_1; pfam01048
405416002470	Uncharacterized protein conserved in bacteria (DUF2062); Region: DUF2062; pfam09835
405416002471	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
405416002472	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
405416002473	trimer interface [polypeptide binding]; other site
405416002474	active site
405416002475	tRNA-dihydrouridine synthase C; Provisional; Region: PRK10550
405416002476	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
405416002477	FMN binding site [chemical binding]; other site
405416002478	active site
405416002479	catalytic residues [active]
405416002480	substrate binding site [chemical binding]; other site
405416002481	Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504
405416002482	signal recognition particle protein; Provisional; Region: PRK10867
405416002483	SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963
405416002484	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
405416002485	GTP binding site [chemical binding]; other site
405416002486	Signal peptide binding domain; Region: SRP_SPB; pfam02978
405416002487	pantothenate kinase; Reviewed; Region: PRK13322
405416002488	Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340
405416002489	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057
405416002490	Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237
405416002491	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
405416002492	Transcriptional regulators [Transcription]; Region: GntR; COG1802
405416002493	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
405416002494	DNA-binding site [nucleotide binding]; DNA binding site
405416002495	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
405416002496	AAA domain; Region: AAA_23; pfam13476
405416002497	Walker A/P-loop; other site
405416002498	ATP binding site [chemical binding]; other site
405416002499	Q-loop/lid; other site
405416002500	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
405416002501	ABC transporter signature motif; other site
405416002502	Walker B; other site
405416002503	D-loop; other site
405416002504	H-loop/switch region; other site
405416002505	ZipA, C-terminal FtsZ-binding domain; Region: ZipA_C; pfam04354
405416002506	FtsZ protein binding site [polypeptide binding]; other site
405416002507	NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956
405416002508	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114
405416002509	nucleotide binding pocket [chemical binding]; other site
405416002510	K-X-D-G motif; other site
405416002511	catalytic site [active]
405416002512	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
405416002513	NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119
405416002514	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027
405416002515	Dimer interface [polypeptide binding]; other site
405416002516	BRCT sequence motif; other site
405416002517	Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193
405416002518	Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907
405416002519	heme binding site [chemical binding]; other site
405416002520	ferroxidase pore; other site
405416002521	ferroxidase diiron center [ion binding]; other site
405416002522	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
405416002523	Major Facilitator Superfamily; Region: MFS_1; pfam07690
405416002524	putative substrate translocation pore; other site
405416002525	Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788
405416002526	alpha,alpha-trehalose-phosphate synthase [UDP-forming]; Region: trehalose_OtsA; TIGR02400
405416002527	active site
405416002528	homotetramer interface [polypeptide binding]; other site
405416002529	Trehalose-6-phosphatase [Carbohydrate transport and metabolism]; Region: OtsB; COG1877
405416002530	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
405416002531	active site
405416002532	motif I; other site
405416002533	motif II; other site
405416002534	carboxylesterase BioH; Provisional; Region: PRK10349
405416002535	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
405416002536	adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK06173
405416002537	inhibitor-cofactor binding pocket; inhibition site
405416002538	pyridoxal 5'-phosphate binding site [chemical binding]; other site
405416002539	catalytic residue [active]
405416002540	8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958
405416002541	pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825
405416002542	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
405416002543	catalytic residue [active]
405416002544	biotin biosynthesis protein BioC; Region: BioC; TIGR02072
405416002545	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
405416002546	S-adenosylmethionine binding site [chemical binding]; other site
405416002547	dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090
405416002548	AAA domain; Region: AAA_26; pfam13500
405416002549	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
405416002550	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
405416002551	RNA binding surface [nucleotide binding]; other site
405416002552	Pseudouridine synthase, Escherichia coli RluB like; Region: PseudoU_synth_RluB; cd02556
405416002553	probable active site [active]
405416002554	Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079
405416002555	ScpA/B protein; Region: ScpA_ScpB; cl00598
405416002556	Telomere recombination; Region: Sua5_yciO_yrdC; cl00305
405416002557	Protein of unknown function, DUF462; Region: DUF462; pfam04315
405416002558	Uncharacterized ACR, COG1399; Region: DUF177; pfam02620
405416002559	50S ribosomal protein L32; Validated; Region: rpmF; PRK01110
405416002560	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
405416002561	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
405416002562	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
405416002563	3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830
405416002564	NAD(P) binding site [chemical binding]; other site
405416002565	homotetramer interface [polypeptide binding]; other site
405416002566	homodimer interface [polypeptide binding]; other site
405416002567	active site
405416002568	acyl carrier protein; Provisional; Region: acpP; PRK00982
405416002569	LysM domain/BON superfamily protein; Provisional; Region: PRK11198
405416002570	BON domain; Region: BON; pfam04972
405416002571	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
405416002572	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
405416002573	dimer interface [polypeptide binding]; other site
405416002574	substrate binding site [chemical binding]; other site
405416002575	ATP binding site [chemical binding]; other site
405416002576	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
405416002577	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
405416002578	motif II; other site
405416002579	3,4-dihydroxy-2-butanone 4-phosphate synthase; Provisional; Region: ribB; PRK03353
405416002580	3,4-dihydroxy-2-butanone 4-phosphate synthase [Coenzyme metabolism]; Region: RibB; COG0108
405416002581	Domain of unknown function (DUF4401); Region: DUF4401; pfam14351
405416002582	GDYXXLXY protein; Region: GDYXXLXY; pfam14345
405416002583	Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent  decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919
405416002584	tetramerization interface [polypeptide binding]; other site
405416002585	active site
405416002586	Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
405416002587	putative active site [active]
405416002588	catalytic residue [active]
405416002589	Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495
405416002590	5S rRNA interface [nucleotide binding]; other site
405416002591	CTC domain interface [polypeptide binding]; other site
405416002592	L16 interface [polypeptide binding]; other site
405416002593	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259
405416002594	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
405416002595	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
405416002596	active site
405416002597	4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00343
405416002598	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
405416002599	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
405416002600	outer membrane lipoprotein LolB; Provisional; Region: lolB; PRK00022
405416002601	Outer membrane lipoprotein LolB; Region: LolB; pfam03550
405416002602	putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917
405416002603	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
405416002604	binding surface
405416002605	TPR motif; other site
405416002606	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
405416002607	binding surface
405416002608	TPR motif; other site
405416002609	glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045
405416002610	NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213
405416002611	tRNA; other site
405416002612	putative tRNA binding site [nucleotide binding]; other site
405416002613	putative NADP binding site [chemical binding]; other site
405416002614	Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745
405416002615	DNA primase; Validated; Region: dnaG; PRK05667
405416002616	CHC2 zinc finger; Region: zf-CHC2; pfam01807
405416002617	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
405416002618	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
405416002619	active site
405416002620	metal binding site [ion binding]; metal-binding site
405416002621	interdomain interaction site; other site
405416002622	DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410
405416002623	Outer membrane lipoprotein; Region: YfiO; pfam13525
405416002624	23S rRNA pseudouridine synthase D; Provisional; Region: rluD; PRK11180
405416002625	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
405416002626	RNA binding surface [nucleotide binding]; other site
405416002627	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
405416002628	active site
405416002629	Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578
405416002630	Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496
405416002631	Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655
405416002632	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
405416002633	Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294
405416002634	SmpB-tmRNA interface; other site
405416002635	phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168
405416002636	Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163
405416002637	active site
405416002638	(T/H)XGH motif; other site
405416002639	Phosphate-selective porin O and P; Region: Porin_O_P; pfam07396
405416002640	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_9; cd08479
405416002641	putative effector binding pocket; other site
405416002642	putative dimerization interface [polypeptide binding]; other site
405416002643	Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473
405416002644	tartrate dehydrogenase; Region: TTC; TIGR02089
405416002645	putative transporter; Provisional; Region: PRK09950
405416002646	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
405416002647	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
405416002648	substrate binding pocket [chemical binding]; other site
405416002649	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
405416002650	Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469
405416002651	[2Fe-2S] cluster binding site [ion binding]; other site
405416002652	C-terminal catalytic domain of the oxygenase alpha subunit of an uncharacterized subgroup of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C_2; cd08886
405416002653	putative alpha subunit interface [polypeptide binding]; other site
405416002654	putative active site [active]
405416002655	putative substrate binding site [chemical binding]; other site
405416002656	Fe binding site [ion binding]; other site
405416002657	succinic semialdehyde dehydrogenase; Region: PLN02278
405416002658	Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103
405416002659	tetramerization interface [polypeptide binding]; other site
405416002660	NAD(P) binding site [chemical binding]; other site
405416002661	catalytic residues [active]
405416002662	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
405416002663	Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal  ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185
405416002664	FMN-binding pocket [chemical binding]; other site
405416002665	flavin binding motif; other site
405416002666	phosphate binding motif [ion binding]; other site
405416002667	beta-alpha-beta structure motif; other site
405416002668	NAD binding pocket [chemical binding]; other site
405416002669	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
405416002670	catalytic loop [active]
405416002671	iron binding site [ion binding]; other site
405416002672	NAD synthetase; Provisional; Region: PRK13981
405416002673	Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570
405416002674	multimer interface [polypeptide binding]; other site
405416002675	active site
405416002676	catalytic triad [active]
405416002677	protein interface 1 [polypeptide binding]; other site
405416002678	NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553
405416002679	homodimer interface [polypeptide binding]; other site
405416002680	NAD binding pocket [chemical binding]; other site
405416002681	ATP binding pocket [chemical binding]; other site
405416002682	Mg binding site [ion binding]; other site
405416002683	active-site loop [active]
405416002684	Pirin; Region: Pirin; pfam02678
405416002685	Pirin-related protein [General function prediction only]; Region: COG1741
405416002686	Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726
405416002687	Uncharacterized protein family (UPF0093); Region: UPF0093; pfam03653
405416002688	3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK07967
405416002689	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
405416002690	dimer interface [polypeptide binding]; other site
405416002691	active site
405416002692	EcsC protein family; Region: EcsC; pfam12787
405416002693	S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368
405416002694	S17 interaction site [polypeptide binding]; other site
405416002695	S8 interaction site; other site
405416002696	16S rRNA interaction site [nucleotide binding]; other site
405416002697	streptomycin interaction site [chemical binding]; other site
405416002698	23S rRNA interaction site [nucleotide binding]; other site
405416002699	aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site
405416002700	30S ribosomal protein S7; Validated; Region: PRK05302
405416002701	elongation factor G; Reviewed; Region: PRK00007
405416002702	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
405416002703	G1 box; other site
405416002704	putative GEF interaction site [polypeptide binding]; other site
405416002705	GTP/Mg2+ binding site [chemical binding]; other site
405416002706	Switch I region; other site
405416002707	G2 box; other site
405416002708	G3 box; other site
405416002709	Switch II region; other site
405416002710	G4 box; other site
405416002711	G5 box; other site
405416002712	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
405416002713	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
405416002714	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
405416002715	Elongation factor Tu GTP binding domain; Region: GTP_EFTU; pfam00009
405416002716	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
405416002717	G1 box; other site
405416002718	GEF interaction site [polypeptide binding]; other site
405416002719	GTP/Mg2+ binding site [chemical binding]; other site
405416002720	Switch I region; other site
405416002721	G2 box; other site
405416002722	G3 box; other site
405416002723	Switch II region; other site
405416002724	G4 box; other site
405416002725	G5 box; other site
405416002726	Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687
405416002727	Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118
405416002728	Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687
405416002729	Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118
405416002730	ribosomal-protein-alanine N-acetyltransferase; Provisional; Region: rimI; PRK09491
405416002731	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
405416002732	Coenzyme A binding pocket [chemical binding]; other site
405416002733	arginyl-tRNA-protein transferase; Provisional; Region: PRK01305
405416002734	Arginine-tRNA-protein transferase, N terminus; Region: ATE_N; pfam04376
405416002735	Arginine-tRNA-protein transferase, C terminus; Region: ATE_C; pfam04377
405416002736	leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301
405416002737	thioredoxin reductase; Provisional; Region: PRK10262
405416002738	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
405416002739	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
405416002740	Domain of unknown function (DUF4117); Region: DUF4117; pfam13491
405416002741	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
405416002742	This domain directs oriented DNA translocation and forms a winged helix structure; Region: Ftsk_gamma; smart00843
405416002743	threonine efflux system; Provisional; Region: PRK10229
405416002744	Septum formation topological specificity factor MinE; Region: MinE; pfam03776
405416002745	Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894
405416002746	Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036
405416002747	Switch I; other site
405416002748	Switch II; other site
405416002749	Septum formation inhibitor [Cell division and chromosome partitioning]; Region: MinC; COG0850
405416002750	Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775
405416002751	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
405416002752	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; Region: LPLAT_LCLAT1-like; cd07990
405416002753	putative acyl-acceptor binding pocket; other site
405416002754	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
405416002755	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
405416002756	ligand binding site [chemical binding]; other site
405416002757	ATP-dependent DNA helicase Rep; Region: rep; TIGR01074
405416002758	Part of AAA domain; Region: AAA_19; pfam13245
405416002759	Family description; Region: UvrD_C_2; pfam13538
405416002760	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
405416002761	trimer interface [polypeptide binding]; other site
405416002762	active site
405416002763	Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109
405416002764	The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089
405416002765	active site
405416002766	substrate binding site [chemical binding]; other site
405416002767	metal binding site [ion binding]; metal-binding site
405416002768	AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250
405416002769	feedback inhibition sensing region; other site
405416002770	homohexameric interface [polypeptide binding]; other site
405416002771	nucleotide binding site [chemical binding]; other site
405416002772	N-acetyl-L-glutamate binding site [chemical binding]; other site
405416002773	Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; pfam13444
405416002774	Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121
405416002775	Glutamine amidotransferases class-II (Gn-AT)_YafJ-type.  YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea.  YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908
405416002776	putative active site [active]
405416002777	putative dimer interface [polypeptide binding]; other site
405416002778	Hemerythrin; Region: Hemerythrin; cd12107
405416002779	Fe binding site [ion binding]; other site
405416002780	Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456
405416002781	hypothetical protein; Validated; Region: PRK01777
405416002782	outer membrane biogenesis protein BamE; Provisional; Region: PRK11548
405416002783	SmpA / OmlA family; Region: SmpA_OmlA; pfam04355
405416002784	ferric uptake regulator; Provisional; Region: fur; PRK09462
405416002785	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
405416002786	metal binding site 2 [ion binding]; metal-binding site
405416002787	putative DNA binding helix; other site
405416002788	metal binding site 1 [ion binding]; metal-binding site
405416002789	dimer interface [polypeptide binding]; other site
405416002790	structural Zn2+ binding site [ion binding]; other site
405416002791	Tfp pilus assembly protein, ATPase PilU [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilU; COG5008
405416002792	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
405416002793	Walker A motif; other site
405416002794	ATP binding site [chemical binding]; other site
405416002795	Walker B motif; other site
405416002796	Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805
405416002797	Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131
405416002798	Walker A motif; other site
405416002799	ATP binding site [chemical binding]; other site
405416002800	Walker B motif; other site
405416002801	Pyridoxal 5-phosphate (PLP)-binding TIM barrel domain of Type III PLP-Dependent Enzymes, Yggs-like proteins; Region: PLPDE_III_Yggs_like; cd06824
405416002802	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
405416002803	catalytic residue [active]
405416002804	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
405416002805	Walker A/P-loop; other site
405416002806	ATP binding site [chemical binding]; other site
405416002807	Q-loop/lid; other site
405416002808	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
405416002809	ABC transporter signature motif; other site
405416002810	Walker B; other site
405416002811	D-loop; other site
405416002812	H-loop/switch region; other site
405416002813	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
405416002814	Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840
405416002815	active site
405416002816	metal binding site [ion binding]; metal-binding site
405416002817	DNA binding site [nucleotide binding]
405416002818	Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320
405416002819	Organic hydroperoxide reductase [Secondary metabolites biosynthesis, transport and catabolism]; Region: osmC; COG1764
405416002820	N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247
405416002821	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
405416002822	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
405416002823	Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090
405416002824	NAD(P) binding site [chemical binding]; other site
405416002825	active site
405416002826	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
405416002827	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
405416002828	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
405416002829	Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823
405416002830	dimer interface [polypeptide binding]; other site
405416002831	allosteric magnesium binding site [ion binding]; other site
405416002832	active site
405416002833	aspartate-rich active site metal binding site; other site
405416002834	Schiff base residues; other site
405416002835	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
405416002836	CoenzymeA binding site [chemical binding]; other site
405416002837	subunit interaction site [polypeptide binding]; other site
405416002838	PHB binding site; other site
405416002839	efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998
405416002840	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
405416002841	HlyD family secretion protein; Region: HlyD_3; pfam13437
405416002842	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
405416002843	Major Facilitator Superfamily; Region: MFS_1; pfam07690
405416002844	putative substrate translocation pore; other site
405416002845	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
405416002846	Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405
405416002847	Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019
405416002848	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
405416002849	AAA domain; Region: AAA_21; pfam13304
405416002850	Walker A/P-loop; other site
405416002851	ATP binding site [chemical binding]; other site
405416002852	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
405416002853	Walker B; other site
405416002854	D-loop; other site
405416002855	H-loop/switch region; other site
405416002856	Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dam; COG0338
405416002857	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
405416002858	Helix-turn-helix domain; Region: HTH_38; pfam13936
405416002859	Homeodomain-like domain; Region: HTH_32; pfam13565
405416002860	Integrase core domain; Region: rve; pfam00665
405416002861	Integrase core domain; Region: rve_3; cl15866
405416002862	outer membrane porin, OprD family; Region: OprD; pfam03573
405416002863	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
405416002864	benzoate transport; Region: 2A0115; TIGR00895
405416002865	putative substrate translocation pore; other site
405416002866	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
405416002867	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
405416002868	Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408
405416002869	inhibitor site; inhibition site
405416002870	active site
405416002871	dimer interface [polypeptide binding]; other site
405416002872	catalytic residue [active]
405416002873	Transcriptional regulator [Transcription]; Region: LysR; COG0583
405416002874	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
405416002875	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
405416002876	dimerization interface [polypeptide binding]; other site
405416002877	RNA polymerase sigma factor; Reviewed; Region: PRK12523
405416002878	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
405416002879	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
405416002880	DNA binding residues [nucleotide binding]
405416002881	Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712
405416002882	FecR protein; Region: FecR; pfam04773
405416002883	Secretin and TonB N terminus short domain; Region: STN; pfam07660
405416002884	TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786
405416002885	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
405416002886	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
405416002887	TPR repeat; Region: TPR_11; pfam13414
405416002888	Protein of unknown function (DUF560); Region: DUF560; pfam04575
405416002889	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
405416002890	Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cd00232
405416002891	heme binding pocket [chemical binding]; other site
405416002892	heme ligand [chemical binding]; other site
405416002893	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2832
405416002894	Protein of unknown function (DUF1275); Region: DUF1275; pfam06912
405416002895	PGAP1-like protein; Region: PGAP1; pfam07819
405416002896	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
405416002897	arginine-ornithine antiporter; Region: arg_ornith_anti; TIGR03810
405416002898	Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574
405416002899	Homocysteine/selenocysteine methylase (S-methylmethionine-dependent) [Amino acid transport and metabolism]; Region: MHT1; COG2040
405416002900	malate:quinone oxidoreductase; Validated; Region: PRK05257
405416002901	malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320
405416002902	choline dehydrogenase; Validated; Region: PRK02106
405416002903	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
405416002904	betaine aldehyde dehydrogenase; Provisional; Region: PRK13252
405416002905	NAD+-dependent 4-trimethylaminobutyraldehyde dehydrogenase, ALDH family 9A1; Region: ALDH_F9_TMBADH; cd07090
405416002906	tetrameric interface [polypeptide binding]; other site
405416002907	NAD binding site [chemical binding]; other site
405416002908	catalytic residues [active]
405416002909	transcriptional regulator BetI; Validated; Region: PRK00767
405416002910	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
405416002911	Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977
405416002912	BCCT family transporter; Region: BCCT; pfam02028
405416002913	choline transport protein BetT; Provisional; Region: PRK09928
405416002914	Multiple antibiotic transporter [Intracellular trafficking and secretion]; Region: MarC; COG2095
405416002915	Brown fat-inducible thioesterase (BFIT).  Brain acyl-CoA hydrolase (BACH).  These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442
405416002916	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
405416002917	CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492
405416002918	C4-dicarboxylate transporter DctA; Reviewed; Region: PRK13027
405416002919	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
405416002920	YaeQ protein; Region: YaeQ; pfam07152
405416002921	FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545
405416002922	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
405416002923	poly-beta-1,6-N-acetyl-D-glucosamine N-deacetylase PgaB; Region: deacetyl_PgaB; TIGR03938
405416002924	N-terminal putative catalytic polysaccharide deacetylase domain of bacterial poly-beta-1,6-N-acetyl-D-glucosamine N-deacetylase PgaB, and similar proteins; Region: CE4_PgaB_5s; cd10964
405416002925	putative active site [active]
405416002926	putative metal binding site [ion binding]; other site
405416002927	N-glycosyltransferase; Provisional; Region: PRK11204
405416002928	CESA_like is  the cellulose synthase superfamily; Region: CESA_like; cd06423
405416002929	DXD motif; other site
405416002930	PgaD-like protein; Region: PgaD; pfam13994
405416002931	enoyl-CoA hydratase; Provisional; Region: PRK06563
405416002932	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
405416002933	substrate binding site [chemical binding]; other site
405416002934	oxyanion hole (OAH) forming residues; other site
405416002935	trimer interface [polypeptide binding]; other site
405416002936	Nicotinamide mononucleotide transporter; Region: NMN_transporter; pfam04973
405416002937	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
405416002938	Transcriptional regulator [Transcription]; Region: IclR; COG1414
405416002939	Bacterial transcriptional regulator; Region: IclR; pfam01614
405416002940	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938
405416002941	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
405416002942	Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469
405416002943	[2Fe-2S] cluster binding site [ion binding]; other site
405416002944	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
405416002945	hydrophobic ligand binding site; other site
405416002946	short chain dehydrogenase; Provisional; Region: PRK12939
405416002947	classical (c) SDRs; Region: SDR_c; cd05233
405416002948	NAD(P) binding site [chemical binding]; other site
405416002949	active site
405416002950	C-terminal domain of Burkholderia sp. NF100 MhqB and similar proteins; MhqB is a type I extradiol dioxygenase involved in the catabolism of methylhydroquinone, an intermediate in the degradation of fenitrothion; Region: MhqB_like_C; cd08360
405416002951	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
405416002952	putative active site [active]
405416002953	putative metal binding site [ion binding]; other site
405416002954	phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754
405416002955	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
405416002956	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
405416002957	D-galactonate transporter; Region: 2A0114; TIGR00893
405416002958	putative substrate translocation pore; other site
405416002959	Cupin domain; Region: Cupin_2; pfam07883
405416002960	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
405416002961	Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303
405416002962	short chain dehydrogenase; Provisional; Region: PRK07062
405416002963	putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344
405416002964	putative NAD(P) binding site [chemical binding]; other site
405416002965	putative active site [active]
405416002966	L-aspartate dehydrogenase; Provisional; Region: PRK13303
405416002967	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
405416002968	Domain of unknown function DUF108; Region: DUF108; pfam01958
405416002969	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
405416002970	Uncharacterized Candidatus pelagibacter aldehyde dehydrogenase, DhaS-like; Region: ALDH_DhaS; cd07114
405416002971	NAD(P) binding site [chemical binding]; other site
405416002972	catalytic residues [active]
405416002973	hypothetical protein; Provisional; Region: PRK07064
405416002974	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
405416002975	PYR/PP interface [polypeptide binding]; other site
405416002976	dimer interface [polypeptide binding]; other site
405416002977	TPP binding site [chemical binding]; other site
405416002978	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
405416002979	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568
405416002980	TPP-binding site [chemical binding]; other site
405416002981	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
405416002982	metabolite-proton symporter; Region: 2A0106; TIGR00883
405416002983	putative substrate translocation pore; other site
405416002984	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
405416002985	active site
405416002986	catalytic residues [active]
405416002987	metal binding site [ion binding]; metal-binding site
405416002988	glutaminase; Provisional; Region: PRK00971
405416002989	Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066
405416002990	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
405416002991	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
405416002992	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
405416002993	putative substrate translocation pore; other site
405416002994	Major Facilitator Superfamily; Region: MFS_1; pfam07690
405416002995	galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019
405416002996	active site
405416002997	catalytic residues [active]
405416002998	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
405416002999	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
405416003000	The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432
405416003001	dimerization interface [polypeptide binding]; other site
405416003002	substrate binding pocket [chemical binding]; other site
405416003003	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
405416003004	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
405416003005	NAD(P) binding site [chemical binding]; other site
405416003006	active site
405416003007	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
405416003008	D-galactonate transporter; Region: 2A0114; TIGR00893
405416003009	putative substrate translocation pore; other site
405416003010	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
405416003011	TPP-binding site [chemical binding]; other site
405416003012	dimer interface [polypeptide binding]; other site
405416003013	Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958
405416003014	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
405416003015	PYR/PP interface [polypeptide binding]; other site
405416003016	dimer interface [polypeptide binding]; other site
405416003017	TPP binding site [chemical binding]; other site
405416003018	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
405416003019	B12-dependent methionine synthase; Provisional; Region: metH; PRK09490
405416003020	Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646
405416003021	MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH).  Cobalamin-dependent...; Region: MeTr; cd00740
405416003022	substrate binding pocket [chemical binding]; other site
405416003023	B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069
405416003024	B12 binding site [chemical binding]; other site
405416003025	cobalt ligand [ion binding]; other site
405416003026	Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965
405416003027	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
405416003028	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
405416003029	D-Serine dehydratase is a pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of L- or D-serine  to pyruvate and ammonia.  D-serine dehydratase serves as a detoxifying enzyme in most E. coli strains where D-serine is a competitive...; Region: D-Ser-dehyd; cd06447
405416003030	Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291
405416003031	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
405416003032	catalytic residue [active]
405416003033	Uncharacterized conserved protein [Function unknown]; Region: COG1262
405416003034	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
405416003035	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
405416003036	Sulfatase; Region: Sulfatase; pfam00884
405416003037	Rhomboid family; Region: Rhomboid; cl11446
405416003038	Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316
405416003039	IscR-regulated protein YhgI; Region: YhgI_GntY; TIGR03341
405416003040	Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694
405416003041	outer membrane receptor FepA; Provisional; Region: PRK13524
405416003042	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
405416003043	N-terminal plug; other site
405416003044	ligand-binding site [chemical binding]; other site
405416003045	Lipase.  Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883
405416003046	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
405416003047	nucleophilic elbow; other site
405416003048	catalytic triad; other site
405416003049	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378
405416003050	active site clefts [active]
405416003051	zinc binding site [ion binding]; other site
405416003052	dimer interface [polypeptide binding]; other site
405416003053	Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822
405416003054	active site
405416003055	catalytic triad [active]
405416003056	oxyanion hole [active]
405416003057	switch loop; other site
405416003058	Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG4181
405416003059	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
405416003060	Walker A/P-loop; other site
405416003061	ATP binding site [chemical binding]; other site
405416003062	Q-loop/lid; other site
405416003063	ABC transporter signature motif; other site
405416003064	Walker B; other site
405416003065	D-loop; other site
405416003066	H-loop/switch region; other site
405416003067	Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127
405416003068	FtsX-like permease family; Region: FtsX; pfam02687
405416003069	FtsX-like permease family; Region: FtsX; pfam02687
405416003070	Rhomboid family; Region: Rhomboid; pfam01694
405416003071	monofunctional biosynthetic peptidoglycan transglycosylase; Provisional; Region: mtgA; PRK00056
405416003072	Transglycosylase; Region: Transgly; cl17702
405416003073	polyphosphate kinase; Provisional; Region: PRK05443
405416003074	Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089
405416003075	Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503
405416003076	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
405416003077	putative active site [active]
405416003078	catalytic site [active]
405416003079	Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168
405416003080	putative active site [active]
405416003081	putative domain interface [polypeptide binding]; other site
405416003082	catalytic site [active]
405416003083	Sporulation related domain; Region: SPOR; cl10051
405416003084	DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151
405416003085	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
405416003086	The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411
405416003087	dimerization interface [polypeptide binding]; other site
405416003088	3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427
405416003089	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
405416003090	NADH:flavorubredoxin oxidoreductase; Provisional; Region: PRK04965
405416003091	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
405416003092	Rubredoxin [Energy production and conversion]; Region: COG1773
405416003093	Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730
405416003094	iron binding site [ion binding]; other site
405416003095	Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814
405416003096	putative hydrophobic ligand binding site [chemical binding]; other site
405416003097	Uncharacterized protein family (UPF0227); Region: UPF0227; cl14886
405416003098	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
405416003099	lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484
405416003100	LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322
405416003101	dimer interface [polypeptide binding]; other site
405416003102	putative anticodon binding site; other site
405416003103	Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775
405416003104	motif 1; other site
405416003105	active site
405416003106	motif 2; other site
405416003107	motif 3; other site
405416003108	Capsule assembly protein Wzi; Region: Caps_assemb_Wzi; pfam14052
405416003109	sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039
405416003110	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
405416003111	Active Sites [active]
405416003112	sulfate adenylyltransferase subunit 1; Provisional; Region: cysN; PRK05124
405416003113	CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166
405416003114	CysD dimerization site [polypeptide binding]; other site
405416003115	G1 box; other site
405416003116	putative GEF interaction site [polypeptide binding]; other site
405416003117	GTP/Mg2+ binding site [chemical binding]; other site
405416003118	Switch I region; other site
405416003119	G2 box; other site
405416003120	G3 box; other site
405416003121	Switch II region; other site
405416003122	G4 box; other site
405416003123	G5 box; other site
405416003124	CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695
405416003125	TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095
405416003126	Uncharacterized protein conserved in bacteria (DUF2239); Region: DUF2239; pfam09998
405416003127	H+/citrate symporter [Energy production and conversion]; Region: CitM; COG2851
405416003128	Citrate transporter; Region: CitMHS; pfam03600
405416003129	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
405416003130	Domain of unknown function DUF21; Region: DUF21; pfam01595
405416003131	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
405416003132	Transporter associated domain; Region: CorC_HlyC; smart01091
405416003133	Transcriptional regulator [Transcription]; Region: LysR; COG0583
405416003134	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
405416003135	The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417
405416003136	substrate binding pocket [chemical binding]; other site
405416003137	dimerization interface [polypeptide binding]; other site
405416003138	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
405416003139	tetramer interface [polypeptide binding]; other site
405416003140	active site
405416003141	Mg2+/Mn2+ binding site [ion binding]; other site
405416003142	isocitrate lyase; Region: PLN02892
405416003143	Uncharacterized lipoprotein NlpE involved in copper resistance [Cell envelope biogenesis, outer membrane / Inorganic ion transport and metabolism]; Region: CutF; COG3015
405416003144	NlpE N-terminal domain; Region: NlpE; pfam04170
405416003145	UreD urease accessory protein; Region: UreD; pfam01774
405416003146	Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390
405416003147	alpha-gamma subunit interface [polypeptide binding]; other site
405416003148	beta-gamma subunit interface [polypeptide binding]; other site
405416003149	Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407
405416003150	gamma-beta subunit interface [polypeptide binding]; other site
405416003151	alpha-beta subunit interface [polypeptide binding]; other site
405416003152	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
405416003153	urease subunit alpha; Reviewed; Region: ureC; PRK13207
405416003154	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
405416003155	active site
405416003156	urease accessory protein UreE; Provisional; Region: ureE; PRK13261
405416003157	UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571
405416003158	dimer interface [polypeptide binding]; other site
405416003159	catalytic residues [active]
405416003160	Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830
405416003161	UreF; Region: UreF; pfam01730
405416003162	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
405416003163	HupE / UreJ protein; Region: HupE_UreJ; pfam04955
405416003164	N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742
405416003165	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
405416003166	S-adenosylmethionine binding site [chemical binding]; other site
405416003167	penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423
405416003168	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
405416003169	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
405416003170	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399
405416003171	adenylate kinase; Reviewed; Region: adk; PRK00279
405416003172	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
405416003173	AMP-binding site [chemical binding]; other site
405416003174	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
405416003175	Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177
405416003176	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
405416003177	minor groove reading motif; other site
405416003178	helix-hairpin-helix signature motif; other site
405416003179	substrate binding pocket [chemical binding]; other site
405416003180	active site
405416003181	Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576
405416003182	ferredoxin; Provisional; Region: PRK08764
405416003183	Putative Fe-S cluster; Region: FeS; cl17515
405416003184	4Fe-4S binding domain; Region: Fer4; pfam00037
405416003185	glutamate dehydrogenase; Provisional; Region: PRK09414
405416003186	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
405416003187	NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313
405416003188	NAD(P) binding site [chemical binding]; other site
405416003189	META domain; Region: META; pfam03724
405416003190	META domain; Region: META; pfam03724
405416003191	Domain of unknown function (DUF4377); Region: DUF4377; pfam14302
405416003192	The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363
405416003193	Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900
405416003194	putative active site [active]
405416003195	metal binding site [ion binding]; metal-binding site
405416003196	rRNA large subunit methyltransferase; Provisional; Region: PRK00103
405416003197	ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466
405416003198	Found in ATP-dependent protease La (LON); Region: LON; smart00464
405416003199	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
405416003200	Walker A motif; other site
405416003201	ATP binding site [chemical binding]; other site
405416003202	Walker B motif; other site
405416003203	arginine finger; other site
405416003204	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
405416003205	Extended Signal Peptide of Type V secretion system; Region: ESPR; pfam13018
405416003206	YadA-like, left-handed beta-roll; Region: LbR_YadA-like; cd12820
405416003207	trimer interface [polypeptide binding]; other site
405416003208	YadA-like, left-handed beta-roll; Region: LbR_YadA-like; cd12820
405416003209	trimer interface [polypeptide binding]; other site
405416003210	Left-handed beta-roll, including virulence factors and various other proteins; Region: LbR-like; cl17507
405416003211	trimer interface [polypeptide binding]; other site
405416003212	YadA-like, left-handed beta-roll; Region: LbR_YadA-like; cd12820
405416003213	trimer interface [polypeptide binding]; other site
405416003214	YadA-like, left-handed beta-roll; Region: LbR_YadA-like; cd12820
405416003215	trimer interface [polypeptide binding]; other site
405416003216	YadA-like C-terminal region; Region: YadA; pfam03895
405416003217	SmpA / OmlA family; Region: SmpA_OmlA; pfam04355
405416003218	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
405416003219	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
405416003220	ligand binding site [chemical binding]; other site
405416003221	5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812
405416003222	5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727
405416003223	serine hydroxymethyltransferase; Reviewed; Region: PRK13034
405416003224	Helix-turn-helix domain; Region: HTH_17; cl17695
405416003225	AAA domain; Region: AAA_24; pfam13479
405416003226	phage nucleotide-binding protein; Region: phage_P_loop; TIGR01618
405416003227	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
405416003228	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
405416003229	non-specific DNA binding site [nucleotide binding]; other site
405416003230	salt bridge; other site
405416003231	sequence-specific DNA binding site [nucleotide binding]; other site
405416003232	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
405416003233	Catalytic site [active]
405416003234	Bacteriophage replication protein O; Region: Phage_rep_O; cl04545
405416003235	Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277
405416003236	putative active site [active]
405416003237	Uncharacterized conserved protein (DUF2280); Region: DUF2280; pfam10045
405416003238	Terminase-like family; Region: Terminase_6; pfam03237
405416003239	Phage terminase large subunit; Region: Terminase_3; cl12054
405416003240	Domain of unknown function (DUF4055); Region: DUF4055; pfam13264
405416003241	Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072
405416003242	Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452
405416003243	Phage protein (N4 Gp49/phage Sf6 gene 66) family; Region: Phage_gp49_66; pfam13876
405416003244	phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554
405416003245	LEM-like domain of lamina-associated polypeptide 2 (LAP2) and similar proteins; Region: LEM_like; cd12935
405416003246	Bacteriophage related domain of unknown function; Region: DUF4128; pfam13554
405416003247	Arc-like DNA binding domain; Region: Arc; pfam03869
405416003248	Prophage antirepressor [Transcription]; Region: COG3617
405416003249	BRO family, N-terminal domain; Region: Bro-N; smart01040
405416003250	Phage-related minor tail protein [Function unknown]; Region: COG5281
405416003251	tape measure domain; Region: tape_meas_nterm; TIGR02675
405416003252	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
405416003253	N-acetyl-D-glucosamine binding site [chemical binding]; other site
405416003254	catalytic residue [active]
405416003255	Domain of unknown function (DUF1833); Region: DUF1833; pfam08875
405416003256	Glycosyl hydrolase 108; Region: Glyco_hydro_108; pfam05838
405416003257	Predicted Peptidoglycan domain; Region: PG_binding_3; pfam09374
405416003258	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
405416003259	phospholipase D; Region: PLN02866
405416003260	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
405416003261	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
405416003262	Domain of unknown function (DUF1705); Region: DUF1705; pfam08019
405416003263	Sulfatase; Region: Sulfatase; pfam00884
405416003264	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
405416003265	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
405416003266	active site
405416003267	Int/Topo IB signature motif; other site
405416003268	DNA binding site [nucleotide binding]
405416003269	Cell division protein ZapA; Region: ZapA; pfam05164
405416003270	Uncharacterized protein family (UPF0149); Region: UPF0149; pfam03695
405416003271	Aminopeptidase P, N-terminal domain; Region: AMP_N; pfam05195
405416003272	proline aminopeptidase P II; Provisional; Region: PRK10879
405416003273	Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087
405416003274	active site
405416003275	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
405416003276	Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988
405416003277	Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988
405416003278	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
405416003279	Cd(II)/Pb(II)-responsive transcriptional regulator; Region: CadR-PbrR; TIGR02047
405416003280	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
405416003281	DNA binding residues [nucleotide binding]
405416003282	Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230
405416003283	Lysine efflux permease [General function prediction only]; Region: COG1279
405416003284	chromosome replication initiation inhibitor protein; Validated; Region: PRK03635
405416003285	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
405416003286	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
405416003287	dimerization interface [polypeptide binding]; other site
405416003288	Menaquinone biosynthesis; Region: VitK2_biosynth; cl17475
405416003289	Predicted methyltransferases [General function prediction only]; Region: COG0313
405416003290	Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648
405416003291	putative SAM binding site [chemical binding]; other site
405416003292	putative homodimer interface [polypeptide binding]; other site
405416003293	hypothetical protein; Provisional; Region: PRK14674
405416003294	Predicted periplasmic or secreted lipoprotein [General function prediction only]; Region: OsmY; COG2823
405416003295	BON domain; Region: BON; pfam04972
405416003296	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
405416003297	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
405416003298	substrate binding pocket [chemical binding]; other site
405416003299	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
405416003300	NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296
405416003301	NADH pyrophosphatase; Reviewed; Region: nudC; PRK00241
405416003302	NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297
405416003303	NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429
405416003304	putative NADH binding site [chemical binding]; other site
405416003305	putative active site [active]
405416003306	nudix motif; other site
405416003307	putative metal binding site [ion binding]; other site
405416003308	RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278
405416003309	RNA/DNA hybrid binding site [nucleotide binding]; other site
405416003310	active site
405416003311	DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406
405416003312	DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131
405416003313	active site
405416003314	catalytic site [active]
405416003315	substrate binding site [chemical binding]; other site
405416003316	membrane-bound lytic murein transglycosylase D; Provisional; Region: mltD; PRK10783
405416003317	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
405416003318	N-acetyl-D-glucosamine binding site [chemical binding]; other site
405416003319	catalytic residue [active]
405416003320	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
405416003321	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
405416003322	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
405416003323	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
405416003324	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
405416003325	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
405416003326	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
405416003327	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
405416003328	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
405416003329	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
405416003330	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
405416003331	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
405416003332	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497
405416003333	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709
405416003334	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4174
405416003335	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
405416003336	dimer interface [polypeptide binding]; other site
405416003337	conserved gate region; other site
405416003338	ABC-ATPase subunit interface; other site
405416003339	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4239
405416003340	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
405416003341	dimer interface [polypeptide binding]; other site
405416003342	conserved gate region; other site
405416003343	putative PBP binding loops; other site
405416003344	ABC-ATPase subunit interface; other site
405416003345	ABC-type uncharacterized transport system, duplicated ATPase component [General function prediction only]; Region: COG4172
405416003346	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
405416003347	Walker A/P-loop; other site
405416003348	ATP binding site [chemical binding]; other site
405416003349	Q-loop/lid; other site
405416003350	ABC transporter signature motif; other site
405416003351	Walker B; other site
405416003352	D-loop; other site
405416003353	H-loop/switch region; other site
405416003354	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
405416003355	Walker A/P-loop; other site
405416003356	ATP binding site [chemical binding]; other site
405416003357	Q-loop/lid; other site
405416003358	ABC transporter signature motif; other site
405416003359	Walker B; other site
405416003360	D-loop; other site
405416003361	H-loop/switch region; other site
405416003362	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
405416003363	Old yellow enzyme (OYE)-related FMN binding domain, group 2.  Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_2_FMN; cd04733
405416003364	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
405416003365	putative active site [active]
405416003366	putative FMN binding site [chemical binding]; other site
405416003367	putative substrate binding site [chemical binding]; other site
405416003368	putative catalytic residue [active]
405416003369	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
405416003370	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
405416003371	N-terminal plug; other site
405416003372	ligand-binding site [chemical binding]; other site
405416003373	DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847
405416003374	DEDDh 3'-5' exonuclease domain of RNase T; Region: RNaseT; cd06134
405416003375	dimer interface [polypeptide binding]; other site
405416003376	catalytic site [active]
405416003377	putative active site [active]
405416003378	putative substrate binding site [chemical binding]; other site
405416003379	Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294
405416003380	active site
405416003381	substrate binding pocket [chemical binding]; other site
405416003382	dimer interface [polypeptide binding]; other site
405416003383	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
405416003384	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
405416003385	metal binding site [ion binding]; metal-binding site
405416003386	active site
405416003387	I-site; other site
405416003388	argininosuccinate synthase; Provisional; Region: PRK13820
405416003389	Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate .  In...; Region: Argininosuccinate_Synthase; cd01999
405416003390	ANP binding site [chemical binding]; other site
405416003391	Substrate Binding Site II [chemical binding]; other site
405416003392	Substrate Binding Site I [chemical binding]; other site
405416003393	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
405416003394	2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli  is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930
405416003395	active site
405416003396	FMN binding site [chemical binding]; other site
405416003397	2,4-decadienoyl-CoA binding site; other site
405416003398	catalytic residue [active]
405416003399	4Fe-4S cluster binding site [ion binding]; other site
405416003400	Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446
405416003401	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
405416003402	Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501
405416003403	Bacterial protein of unknown function (DUF898); Region: DUF898; pfam05987
405416003404	ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464
405416003405	NLPA lipoprotein; Region: Lipoprotein_9; pfam03180
405416003406	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
405416003407	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
405416003408	Uncharacterized protein conserved in bacteria [Function unknown]; Region: VgrG; COG3501
405416003409	Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954
405416003410	Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717
405416003411	Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296
405416003412	Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; pfam10106
405416003413	RHS Repeat; Region: RHS_repeat; pfam05593
405416003414	Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209
405416003415	RHS Repeat; Region: RHS_repeat; pfam05593
405416003416	RHS Repeat; Region: RHS_repeat; pfam05593
405416003417	RHS Repeat; Region: RHS_repeat; pfam05593
405416003418	RHS Repeat; Region: RHS_repeat; cl11982
405416003419	RHS protein; Region: RHS; pfam03527
405416003420	RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696
405416003421	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
405416003422	Sel1-like repeats; Region: SEL1; smart00671
405416003423	Sel1-like repeats; Region: SEL1; smart00671
405416003424	Sel1-like repeats; Region: SEL1; smart00671
405416003425	Sel1-like repeats; Region: SEL1; smart00671
405416003426	Sel1-like repeats; Region: SEL1; smart00671
405416003427	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
405416003428	Sel1-like repeats; Region: SEL1; smart00671
405416003429	Sel1-like repeats; Region: SEL1; smart00671
405416003430	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
405416003431	Sel1 repeat; Region: Sel1; cl02723
405416003432	Sel1-like repeats; Region: SEL1; smart00671
405416003433	Sel1-like repeats; Region: SEL1; smart00671
405416003434	Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113
405416003435	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
405416003436	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
405416003437	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
405416003438	Transcriptional regulators [Transcription]; Region: FadR; COG2186
405416003439	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
405416003440	DNA-binding site [nucleotide binding]; DNA binding site
405416003441	FCD domain; Region: FCD; pfam07729
405416003442	SnoaL-like domain; Region: SnoaL_2; pfam12680
405416003443	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
405416003444	gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK13473
405416003445	Escherichia coli NAD+-dependent gamma-aminobutyraldehyde dehydrogenase YdcW-like; Region: ALDH_ABALDH-YdcW; cd07092
405416003446	tetrameric interface [polypeptide binding]; other site
405416003447	NAD binding site [chemical binding]; other site
405416003448	catalytic residues [active]
405416003449	substrate binding site [chemical binding]; other site
405416003450	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
405416003451	AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404
405416003452	AsnC family; Region: AsnC_trans_reg; pfam01037
405416003453	bifunctional succinylornithine transaminase/acetylornithine transaminase; Provisional; Region: PRK12381
405416003454	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
405416003455	inhibitor-cofactor binding pocket; inhibition site
405416003456	pyridoxal 5'-phosphate binding site [chemical binding]; other site
405416003457	catalytic residue [active]
405416003458	Arginine/ornithine N-succinyltransferase beta subunit [Amino acid transport and metabolism]; Region: AstA; COG3138
405416003459	Arginine N-succinyltransferase beta subunit; Region: AstA; cl11440
405416003460	D-alanine/D-serine/glycine permease; Provisional; Region: PRK11049
405416003461	aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381
405416003462	Coniferyl aldehyde dehydrogenase-like; Region: ALDH_CALDH_CalB; cd07133
405416003463	NAD(P) binding site [chemical binding]; other site
405416003464	catalytic residues [active]
405416003465	DDE domain; Region: DDE_Tnp_IS240; pfam13610
405416003466	Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687
405416003467	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
405416003468	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
405416003469	Pirin-related protein [General function prediction only]; Region: COG1741
405416003470	Pirin; Region: Pirin; pfam02678
405416003471	Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118
405416003472	Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687
405416003473	classical (c) SDRs; Region: SDR_c; cd05233
405416003474	short chain dehydrogenase; Provisional; Region: PRK05650
405416003475	NAD(P) binding site [chemical binding]; other site
405416003476	active site
405416003477	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
405416003478	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
405416003479	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
405416003480	Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816
405416003481	Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320
405416003482	active site
405416003483	purine riboside binding site [chemical binding]; other site
405416003484	Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038
405416003485	bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182
405416003486	RNA/DNA hybrid binding site [nucleotide binding]; other site
405416003487	active site
405416003488	carbon storage regulator; Provisional; Region: PRK01712
405416003489	aspartate kinase; Reviewed; Region: PRK06635
405416003490	AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261
405416003491	putative nucleotide binding site [chemical binding]; other site
405416003492	putative catalytic residues [active]
405416003493	putative Mg ion binding site [ion binding]; other site
405416003494	putative aspartate binding site [chemical binding]; other site
405416003495	ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913
405416003496	putative allosteric regulatory site; other site
405416003497	ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936
405416003498	alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252
405416003499	Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673
405416003500	motif 1; other site
405416003501	active site
405416003502	motif 2; other site
405416003503	motif 3; other site
405416003504	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
405416003505	DHHA1 domain; Region: DHHA1; pfam02272
405416003506	Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057
405416003507	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846
405416003508	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
405416003509	ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: PRK12421
405416003510	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
405416003511	dimer interface [polypeptide binding]; other site
405416003512	motif 1; other site
405416003513	active site
405416003514	motif 2; other site
405416003515	motif 3; other site
405416003516	Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788
405416003517	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
405416003518	Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108
405416003519	Peptidase family M48; Region: Peptidase_M48; pfam01435
405416003520	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
405416003521	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
405416003522	active site
405416003523	catalytic tetrad [active]
405416003524	DNA-binding transcriptional dual regulator Crp; Provisional; Region: PRK11753
405416003525	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
405416003526	ligand binding site [chemical binding]; other site
405416003527	flexible hinge region; other site
405416003528	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
405416003529	putative switch regulator; other site
405416003530	non-specific DNA interactions [nucleotide binding]; other site
405416003531	DNA binding site [nucleotide binding]
405416003532	sequence specific DNA binding site [nucleotide binding]; other site
405416003533	putative cAMP binding site [chemical binding]; other site
405416003534	OsmC-like protein; Region: OsmC; cl00767
405416003535	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
405416003536	Coenzyme A binding pocket [chemical binding]; other site
405416003537	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
405416003538	Peptidase family M23; Region: Peptidase_M23; pfam01551
405416003539	ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346
405416003540	Clp amino terminal domain; Region: Clp_N; pfam02861
405416003541	Clp amino terminal domain; Region: Clp_N; pfam02861
405416003542	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
405416003543	Walker A motif; other site
405416003544	ATP binding site [chemical binding]; other site
405416003545	Walker B motif; other site
405416003546	arginine finger; other site
405416003547	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
405416003548	Walker A motif; other site
405416003549	ATP binding site [chemical binding]; other site
405416003550	Walker B motif; other site
405416003551	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
405416003552	Competence-damaged protein; Region: CinA; pfam02464
405416003553	23S rRNA m(2)G2445 methyltransferase; Provisional; Region: rlmL; PRK11783
405416003554	THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715
405416003555	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
405416003556	DNA methylase; Region: N6_N4_Mtase; cl17433
405416003557	aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856
405416003558	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
405416003559	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
405416003560	dihydroorotase; Validated; Region: pyrC; PRK09357
405416003561	Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317
405416003562	active site
405416003563	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
405416003564	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
405416003565	ligand binding site [chemical binding]; other site
405416003566	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807
405416003567	Domain of unknown function (DUF2520); Region: DUF2520; pfam10728
405416003568	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
405416003569	GST_N family, unknown subfamily 2; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_2; cd03047
405416003570	putative C-terminal domain interface [polypeptide binding]; other site
405416003571	putative GSH binding site (G-site) [chemical binding]; other site
405416003572	putative dimer interface [polypeptide binding]; other site
405416003573	C-terminal, alpha helical domain of an unknown subfamily 2 of Glutathione S-transferases; Region: GST_C_2; cd03180
405416003574	putative N-terminal domain interface [polypeptide binding]; other site
405416003575	putative dimer interface [polypeptide binding]; other site
405416003576	putative substrate binding pocket (H-site) [chemical binding]; other site
405416003577	tRNA (guanine-N(7)-)-methyltransferase; Reviewed; Region: trmB; PRK00121
405416003578	Predicted extracellular nuclease [General function prediction only]; Region: COG2374
405416003579	YhcR_OBF_like: A subfamily of OB-fold domains similar to the OB folds of Bacillus subtilis YhcR. YhcR is a sugar-nonspecific nuclease, which is active in the presence of Ca2+ and Mn2+. It cleaves RNA endonucleolytically, producing 3'-monophosphate...; Region: YhcR_OBF_like; cd04486
405416003580	generic binding surface II; other site
405416003581	generic binding surface I; other site
405416003582	Mycoplasma pulmonis MnuA nuclease-like; Region: MnuA_DNase1-like; cd10283
405416003583	putative active site [active]
405416003584	putative catalytic site [active]
405416003585	putative Mg binding site IVb [ion binding]; other site
405416003586	putative phosphate binding site [ion binding]; other site
405416003587	putative DNA binding site [nucleotide binding]; other site
405416003588	putative Mg binding site IVa [ion binding]; other site
405416003589	glutathionine S-transferase; Provisional; Region: PRK10542
405416003590	GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057
405416003591	C-terminal domain interface [polypeptide binding]; other site
405416003592	GSH binding site (G-site) [chemical binding]; other site
405416003593	dimer interface [polypeptide binding]; other site
405416003594	C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188
405416003595	dimer interface [polypeptide binding]; other site
405416003596	N-terminal domain interface [polypeptide binding]; other site
405416003597	substrate binding pocket (H-site) [chemical binding]; other site
405416003598	alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317
405416003599	Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974
405416003600	catalytic residue [active]
405416003601	TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026
405416003602	catalytic residues [active]
405416003603	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
405416003604	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
405416003605	Protein of unknown function (DUF1653); Region: DUF1653; pfam07866
405416003606	Predicted O-methyltransferase [General function prediction only]; Region: COG4122
405416003607	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
405416003608	S-adenosylmethionine binding site [chemical binding]; other site
405416003609	KTSC domain; Region: KTSC; pfam13619
405416003610	peroxiredoxin; Region: AhpC; TIGR03137
405416003611	Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015
405416003612	dimer interface [polypeptide binding]; other site
405416003613	decamer (pentamer of dimers) interface [polypeptide binding]; other site
405416003614	catalytic triad [active]
405416003615	peroxidatic and resolving cysteines [active]
405416003616	ATP-dependent helicase HrpA; Region: DEAH_box_HrpA; TIGR01967
405416003617	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
405416003618	ATP binding site [chemical binding]; other site
405416003619	putative Mg++ binding site [ion binding]; other site
405416003620	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
405416003621	nucleotide binding region [chemical binding]; other site
405416003622	ATP-binding site [chemical binding]; other site
405416003623	Helicase associated domain (HA2); Region: HA2; pfam04408
405416003624	Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717
405416003625	Domain of unknown function (DUF3418); Region: DUF3418; pfam11898
405416003626	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK07515
405416003627	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
405416003628	dimer interface [polypeptide binding]; other site
405416003629	active site
405416003630	CoA binding pocket [chemical binding]; other site
405416003631	outer membrane porin, OprD family; Region: OprD; pfam03573
405416003632	benzoate transport; Region: 2A0115; TIGR00895
405416003633	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
405416003634	putative substrate translocation pore; other site
405416003635	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
405416003636	putative substrate translocation pore; other site
405416003637	benzoate transporter; Region: benE; TIGR00843
405416003638	Benzoate membrane transport protein; Region: BenE; pfam03594
405416003639	1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate dehydrogenase; Provisional; Region: benD; PRK12823
405416003640	1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate dehydrogenase (DHB DH)-like, classical (c) SDR; Region: DHB_DH-like_SDR_c; cd08937
405416003641	putative NAD(P) binding site [chemical binding]; other site
405416003642	active site
405416003643	anthranilate dioxygenase reductase; Provisional; Region: antC; PRK11872
405416003644	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
405416003645	catalytic loop [active]
405416003646	iron binding site [ion binding]; other site
405416003647	Benzoate dioxygenase reductase (BenDO) FAD/NAD binding domain. Oxygenases oxidize hydrocarbons using dioxygen as the oxidant. As a Class I bacterial dioxygenases, benzoate dioxygenase like proteins combine an [2Fe-2S] cluster containing N-terminal...; Region: BenDO_FAD_NAD; cd06209
405416003648	FAD binding pocket [chemical binding]; other site
405416003649	FAD binding motif [chemical binding]; other site
405416003650	phosphate binding motif [ion binding]; other site
405416003651	beta-alpha-beta structure motif; other site
405416003652	NAD binding pocket [chemical binding]; other site
405416003653	Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667
405416003654	inter-subunit interface; other site
405416003655	benzoate 1,2-dioxygenase, large subunit; Region: benzo_1_2_benA; TIGR03229
405416003656	Rieske non-heme iron oxygenase (RO) family, 2-Halobenzoate 1,2-dioxygenase (HBDO) subfamily, N-terminal Rieske domain of the oxygenase alpha subunit; ROs comprise a large class of aromatic ring-hydroxylating dioxygenases that enable microorganisms to...; Region: Rieske_RO_Alpha_HBDO; cd03542
405416003657	C-terminal catalytic domain of the oxygenase alpha subunit of Pseudomonas resinovorans strain CA10 anthranilate 1,2-dioxygenase and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_AntDO-like; cd08879
405416003658	putative alpha subunit interface [polypeptide binding]; other site
405416003659	putative active site [active]
405416003660	putative substrate binding site [chemical binding]; other site
405416003661	Fe binding site [ion binding]; other site
405416003662	DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906
405416003663	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
405416003664	The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in benzoate catabolism; contains the type 2 periplasmic binding fold; Region: PBP2_BenM_CatM_CatR; cd08445
405416003665	dimerizarion interface [polypeptide binding]; other site
405416003666	CrgA pocket; other site
405416003667	substrate binding pocket [chemical binding]; other site
405416003668	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
405416003669	metal-binding site [ion binding]
405416003670	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
405416003671	metal-binding site [ion binding]
405416003672	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
405416003673	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
405416003674	metal-binding site [ion binding]
405416003675	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
405416003676	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
405416003677	motif II; other site
405416003678	Cu(I)-responsive transcriptional regulator; Region: CueR; TIGR02044
405416003679	Helix-Turn-Helix DNA binding domain of CueR-like transcription regulators; Region: HTH_CueR; cd01108
405416003680	DNA binding residues [nucleotide binding]
405416003681	dimer interface [polypeptide binding]; other site
405416003682	copper binding site [ion binding]; other site
405416003683	Glutathione-dependent formaldehyde-activating enzyme; Region: GFA; pfam04828
405416003684	Cysteine-rich 4 helical bundle widely conserved in bacteria; Region: DUF326; cd08026
405416003685	dimerization interface [polypeptide binding]; other site
405416003686	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
405416003687	exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286
405416003688	ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489
405416003689	generic binding surface II; other site
405416003690	generic binding surface I; other site
405416003691	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
405416003692	Predicted transcriptional regulator [Transcription]; Region: COG2932
405416003693	non-specific DNA binding site [nucleotide binding]; other site
405416003694	salt bridge; other site
405416003695	sequence-specific DNA binding site [nucleotide binding]; other site
405416003696	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
405416003697	Catalytic site [active]
405416003698	Glycosyl hydrolase 108; Region: Glyco_hydro_108; pfam05838
405416003699	Predicted Peptidoglycan domain; Region: PG_binding_3; pfam09374
405416003700	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
405416003701	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
405416003702	DNA-binding site [nucleotide binding]; DNA binding site
405416003703	RNA-binding motif; other site
405416003704	pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880
405416003705	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232
405416003706	Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072
405416003707	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
405416003708	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
405416003709	putative substrate translocation pore; other site
405416003710	Predicted transcriptional regulators [Transcription]; Region: COG1733
405416003711	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
405416003712	Domain of unknown function (DUF4142); Region: DUF4142; pfam13628
405416003713	cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260
405416003714	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
405416003715	active site
405416003716	HIGH motif; other site
405416003717	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
405416003718	KMSKS motif; other site
405416003719	Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963
405416003720	tRNA binding surface [nucleotide binding]; other site
405416003721	anticodon binding site; other site
405416003722	D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892
405416003723	KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014
405416003724	putative active site [active]
405416003725	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein.  These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604
405416003726	HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662
405416003727	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
405416003728	active site
405416003729	motif I; other site
405416003730	motif II; other site
405416003731	Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835
405416003732	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3117; cl01200
405416003733	lipopolysaccharide transport periplasmic protein LptA; Region: outer_YhbN_LptA; TIGR03002
405416003734	OstA-like protein; Region: OstA; pfam03968
405416003735	ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137
405416003736	ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218
405416003737	Walker A/P-loop; other site
405416003738	ATP binding site [chemical binding]; other site
405416003739	Q-loop/lid; other site
405416003740	ABC transporter signature motif; other site
405416003741	Walker B; other site
405416003742	D-loop; other site
405416003743	H-loop/switch region; other site
405416003744	type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844
405416003745	type I secretion system ATPase, LssB family; Region: type_I_sec_LssB; TIGR03375
405416003746	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
405416003747	ATP-binding cassette domain of bacteriocin exporters, subfamily C; Region: ABCC_bacteriocin_exporters; cd03245
405416003748	Walker A/P-loop; other site
405416003749	ATP binding site [chemical binding]; other site
405416003750	Q-loop/lid; other site
405416003751	ABC transporter signature motif; other site
405416003752	Walker B; other site
405416003753	D-loop; other site
405416003754	H-loop/switch region; other site
405416003755	type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843
405416003756	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
405416003757	HlyD family secretion protein; Region: HlyD_3; pfam13437
405416003758	Uncharacterized conserved protein [Function unknown]; Region: COG1739
405416003759	Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205
405416003760	Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110
405416003761	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
405416003762	putative trimer interface [polypeptide binding]; other site
405416003763	Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647
405416003764	trimer interface [polypeptide binding]; other site
405416003765	active site
405416003766	substrate binding site [chemical binding]; other site
405416003767	putative CoA binding site [chemical binding]; other site
405416003768	CoA binding site [chemical binding]; other site
405416003769	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
405416003770	Ligand Binding Site [chemical binding]; other site
405416003771	Predicted O-methyltransferase [General function prediction only]; Region: COG4122
405416003772	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
405416003773	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3108
405416003774	Ferredoxin [Energy production and conversion]; Region: COG1146
405416003775	4Fe-4S binding domain; Region: Fer4; cl02805
405416003776	Domain of unknown function (DUF3470); Region: DUF3470; pfam11953
405416003777	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
405416003778	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
405416003779	Coenzyme A binding pocket [chemical binding]; other site
405416003780	DNA mismatch repair protein MutS; Provisional; Region: PRK05399
405416003781	MutS domain I; Region: MutS_I; pfam01624
405416003782	MutS domain II; Region: MutS_II; pfam05188
405416003783	MutS domain III; Region: MutS_III; pfam05192
405416003784	MutS domain V; Region: MutS_V; pfam00488
405416003785	Walker A/P-loop; other site
405416003786	ATP binding site [chemical binding]; other site
405416003787	Q-loop/lid; other site
405416003788	ABC transporter signature motif; other site
405416003789	Walker B; other site
405416003790	D-loop; other site
405416003791	H-loop/switch region; other site
405416003792	putative transposase OrfB; Reviewed; Region: PHA02517
405416003793	HTH-like domain; Region: HTH_21; pfam13276
405416003794	Integrase core domain; Region: rve; pfam00665
405416003795	Integrase core domain; Region: rve_3; pfam13683
405416003796	AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404
405416003797	putative DNA binding site [nucleotide binding]; other site
405416003798	putative Zn2+ binding site [ion binding]; other site
405416003799	Threonine/homoserine efflux transporter [Amino acid transport and metabolism]; Region: rhtA; COG5006
405416003800	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
405416003801	Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279
405416003802	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
405416003803	putative acyl-acceptor binding pocket; other site
405416003804	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
405416003805	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
405416003806	benzoate transport; Region: 2A0115; TIGR00895
405416003807	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
405416003808	putative substrate translocation pore; other site
405416003809	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
405416003810	Uncharacterized protein conserved in bacteria (DUF2147); Region: DUF2147; pfam09917
405416003811	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
405416003812	Helix-Turn-Helix DNA binding domain of the transcription regulators NolA and AlbR; Region: HTH_NolA-AlbR; cd04788
405416003813	DNA binding residues [nucleotide binding]
405416003814	putative dimer interface [polypeptide binding]; other site
405416003815	TipAS antibiotic-recognition domain; Region: TipAS; pfam07739
405416003816	TipAS antibiotic-recognition domain; Region: TipAS; pfam07739
405416003817	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
405416003818	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
405416003819	Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508
405416003820	Coenzyme A binding pocket [chemical binding]; other site
405416003821	Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419
405416003822	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
405416003823	motif II; other site
405416003824	Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354
405416003825	Uncharacterized protein conserved in bacteria [Function unknown]; Region: VgrG; COG3501
405416003826	Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954
405416003827	Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717
405416003828	Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296
405416003829	Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; pfam10106
405416003830	RHS Repeat; Region: RHS_repeat; pfam05593
405416003831	Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209
405416003832	RHS Repeat; Region: RHS_repeat; pfam05593
405416003833	RHS Repeat; Region: RHS_repeat; pfam05593
405416003834	RHS Repeat; Region: RHS_repeat; pfam05593
405416003835	RHS Repeat; Region: RHS_repeat; pfam05593
405416003836	RHS Repeat; Region: RHS_repeat; pfam05593
405416003837	RHS protein; Region: RHS; pfam03527
405416003838	RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696
405416003839	transcriptional regulator, ArgP family; Region: argP; TIGR03298
405416003840	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
405416003841	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
405416003842	dimerization interface [polypeptide binding]; other site
405416003843	Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914
405416003844	LamB/YcsF family of  lactam utilization protein; Region: LamB_YcsF_like; cd10787
405416003845	putative active site [active]
405416003846	hypothetical protein; Provisional; Region: PRK05463
405416003847	Allophanate hydrolase subunit 1; Region: AHS1; pfam02682
405416003848	Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896
405416003849	Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896
405416003850	Allophanate hydrolase subunit 2; Region: AHS2; pfam02626
405416003851	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
405416003852	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
405416003853	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
405416003854	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
405416003855	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
405416003856	carboxyltransferase (CT) interaction site; other site
405416003857	biotinylation site [posttranslational modification]; other site
405416003858	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
405416003859	ClC sycA-like chloride channel proteins. This ClC family presents in bacteria, where it facilitates acid resistance in acidic soil. Mutation of this gene (sycA) in Rhizobium tropici CIAT899 causes serious deficiencies in nodule development, nodulation...; Region: ClC_sycA_like; cd03682
405416003860	putative Cl- selectivity filter; other site
405416003861	putative pore gating glutamate residue; other site
405416003862	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
405416003863	Sel1-like repeats; Region: SEL1; smart00671
405416003864	Sel1-like repeats; Region: SEL1; smart00671
405416003865	Sel1-like repeats; Region: SEL1; smart00671
405416003866	Sel1-like repeats; Region: SEL1; smart00671
405416003867	Sel1-like repeats; Region: SEL1; smart00671
405416003868	Sel1-like repeats; Region: SEL1; smart00671
405416003869	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
405416003870	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
405416003871	Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821
405416003872	putative hydrophobic ligand binding site [chemical binding]; other site
405416003873	protein interface [polypeptide binding]; other site
405416003874	gate; other site
405416003875	Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283
405416003876	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
405416003877	NAD binding site [chemical binding]; other site
405416003878	catalytic Zn binding site [ion binding]; other site
405416003879	structural Zn binding site [ion binding]; other site
405416003880	urea carboxylase-associated protein 1; Region: urea_degr_1; TIGR03424
405416003881	urea carboxylase-associated protein 2; Region: urea_degr_2; TIGR03425
405416003882	urea carboxylase-associated protein 1; Region: urea_degr_1; TIGR03424
405416003883	Domain of unknown function (DUF1989); Region: DUF1989; pfam09347
405416003884	urea carboxylase; Region: urea_carbox; TIGR02712
405416003885	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
405416003886	ATP-grasp domain; Region: ATP-grasp_4; cl17255
405416003887	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
405416003888	Allophanate hydrolase subunit 2; Region: AHS2; smart00797
405416003889	Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896
405416003890	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
405416003891	carboxyltransferase (CT) interaction site; other site
405416003892	biotinylation site [posttranslational modification]; other site
405416003893	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
405416003894	Predicted transcriptional regulators [Transcription]; Region: COG1733
405416003895	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
405416003896	nickel responsive regulator; Provisional; Region: PRK04460
405416003897	NikR C terminal nickel binding domain; Region: NikR_C; pfam08753
405416003898	allophanate hydrolase; Provisional; Region: PRK08186
405416003899	Amidase; Region: Amidase; cl11426
405416003900	ABC transporter periplasmic binding protein, urea carboxylase region; Region: ABC_peri_uca; TIGR03427
405416003901	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
405416003902	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
405416003903	Walker A/P-loop; other site
405416003904	ATP binding site [chemical binding]; other site
405416003905	Q-loop/lid; other site
405416003906	ABC transporter signature motif; other site
405416003907	Walker B; other site
405416003908	D-loop; other site
405416003909	H-loop/switch region; other site
405416003910	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
405416003911	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
405416003912	dimer interface [polypeptide binding]; other site
405416003913	conserved gate region; other site
405416003914	putative PBP binding loops; other site
405416003915	ABC-ATPase subunit interface; other site
405416003916	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4460
405416003917	Protein of unknown function (DUF770); Region: DUF770; pfam05591
405416003918	Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and    vesicular transport]; Region: COG3517; cl05484
405416003919	Protein of unknown function (DUF877); Region: DUF877; pfam05943
405416003920	Protein of unknown function (DUF796); Region: DUF796; pfam05638
405416003921	type VI secretion system lysozyme-like protein; Region: VI_zyme; TIGR03357
405416003922	Type VI protein secretion system component VasA [Intracellular trafficking, secretion, and    vesicular transport]; Region: COG3519
405416003923	Bacterial protein of unknown function (DUF879); Region: DUF879; cl15462
405416003924	Protein of unknown function (DUF1305); Region: DUF1305; pfam06996
405416003925	Type VI protein secretion system component VasK [Intracellular trafficking, secretion, and    vesicular transport]; Region: IcmF; COG3523
405416003926	Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761
405416003927	Protein of unknown function (DUF1215); Region: DUF1215; pfam06744
405416003928	Uncharacterized protein conserved in bacteria (DUF2094); Region: DUF2094; cl01611
405416003929	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
405416003930	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
405416003931	ligand binding site [chemical binding]; other site
405416003932	PAAR motif; Region: PAAR_motif; pfam05488
405416003933	type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345
405416003934	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
405416003935	Walker A motif; other site
405416003936	ATP binding site [chemical binding]; other site
405416003937	Walker B motif; other site
405416003938	arginine finger; other site
405416003939	JNK_SAPK-associated protein-1; Region: Jnk-SapK_ap_N; pfam09744
405416003940	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
405416003941	Walker A motif; other site
405416003942	ATP binding site [chemical binding]; other site
405416003943	Walker B motif; other site
405416003944	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
405416003945	type VI secretion-associated protein, ImpA family; Region: VI_chp_8; TIGR03363
405416003946	ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812
405416003947	type VI secretion protein, VC_A0114 family; Region: VI_chp_4; TIGR03353
405416003948	Bacterial protein of unknown function (DUF876); Region: DUF876; pfam05936
405416003949	type IV / VI secretion system protein, DotU family; Region: IV_VI_DotU; TIGR03349
405416003950	D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557
405416003951	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_M15_4; pfam13539
405416003952	Transcriptional regulator [Transcription]; Region: LysR; COG0583
405416003953	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
405416003954	LysR substrate binding domain; Region: LysR_substrate; pfam03466
405416003955	dimerization interface [polypeptide binding]; other site
405416003956	Ankyrin repeats (many copies); Region: Ank_4; pfam13637
405416003957	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
405416003958	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
405416003959	Ankyrin repeats (many copies); Region: Ank_4; pfam13637
405416003960	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
405416003961	nucleoside/Zn binding site; other site
405416003962	dimer interface [polypeptide binding]; other site
405416003963	catalytic motif [active]
405416003964	putative cyanate transporter; Provisional; Region: cynX; PRK09705
405416003965	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
405416003966	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214
405416003967	Protein of unknown function (DUF1006); Region: DUF1006; pfam06224
405416003968	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
405416003969	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
405416003970	Coenzyme A binding pocket [chemical binding]; other site
405416003971	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1636
405416003972	redox-sensitive transcriptional activator SoxR; Region: SoxR; TIGR01950
405416003973	Helix-Turn-Helix DNA binding domain of the SoxR transcription regulator; Region: HTH_SoxR; cd01110
405416003974	DNA binding residues [nucleotide binding]
405416003975	dimer interface [polypeptide binding]; other site
405416003976	[2Fe-2S] cluster binding site [ion binding]; other site
405416003977	Putative hemolysin [General function prediction only]; Region: Hlx; COG3042
405416003978	Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139
405416003979	Domain of unknown function (DUF333); Region: DUF333; pfam03891
405416003980	Peptidase inhibitor I78 family; Region: Inhibitor_I78; pfam11720
405416003981	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
405416003982	Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408
405416003983	inhibitor site; inhibition site
405416003984	active site
405416003985	dimer interface [polypeptide binding]; other site
405416003986	catalytic residue [active]
405416003987	EamA-like transporter family; Region: EamA; pfam00892
405416003988	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
405416003989	Transcriptional regulators [Transcription]; Region: GntR; COG1802
405416003990	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
405416003991	DNA-binding site [nucleotide binding]; DNA binding site
405416003992	FCD domain; Region: FCD; pfam07729
405416003993	hydroxyproline-2-epimerase; Provisional; Region: PRK13970
405416003994	hydroxyproline-2-epimerase; Provisional; Region: PRK13971
405416003995	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
405416003996	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
405416003997	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510
405416003998	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992
405416003999	PAS fold; Region: PAS_4; pfam08448
405416004000	Helix-turn-helix domain; Region: HTH_18; pfam12833
405416004001	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
405416004002	metabolite-proton symporter; Region: 2A0106; TIGR00883
405416004003	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
405416004004	putative substrate translocation pore; other site
405416004005	NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012
405416004006	Alpha-Ketoglutaric Semialdehyde Dehydrogenase; Region: ALDH_KGSADH; cd07129
405416004007	dimer interface [polypeptide binding]; other site
405416004008	NADP binding site [chemical binding]; other site
405416004009	catalytic residues [active]
405416004010	amino acid transporter; Region: 2A0306; TIGR00909
405416004011	L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720
405416004012	Serine dehydratase beta chain; Region: SDH_beta; pfam03315
405416004013	Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313
405416004014	bifunctional aldehyde dehydrogenase/enoyl-CoA hydratase; Provisional; Region: PRK11563
405416004015	N-terminal domain of the monoamine oxidase C dehydratase; Region: ALDH_MaoC-N; cd07128
405416004016	substrate binding site [chemical binding]; other site
405416004017	dimer interface [polypeptide binding]; other site
405416004018	NADP binding site [chemical binding]; other site
405416004019	catalytic residues [active]
405416004020	MaoC_C  The C-terminal hot dog fold of the MaoC (monoamine oxidase C) dehydratase regulatory protein. Orthologs of MaoC include PaaZ [Escherichia coli] and PaaN [Pseudomonas putida], which are putative ring-opening enzymes involved in phenylacetic acid...; Region: MaoC_C; cd03452
405416004021	substrate binding site [chemical binding]; other site
405416004022	phenylacetate-CoA oxygenase subunit PaaA; Provisional; Region: paaA; PRK13778
405416004023	phenylacetate-CoA oxygenase, PaaG subunit; Region: PA_CoA_Oxy1; TIGR02156
405416004024	phenylacetate-CoA oxygenase subunit PaaB; Provisional; Region: paaB; PRK13781
405416004025	Phenylacetic acid catabolic protein; Region: PaaA_PaaC; pfam05138
405416004026	Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151
405416004027	phenylacetate-CoA oxygenase, PaaJ subunit; Region: PA_CoA_Oxy4; TIGR02159
405416004028	phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160
405416004029	NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214
405416004030	FAD binding pocket [chemical binding]; other site
405416004031	FAD binding motif [chemical binding]; other site
405416004032	phosphate binding motif [ion binding]; other site
405416004033	beta-alpha-beta structure motif; other site
405416004034	NAD(p) ribose binding residues [chemical binding]; other site
405416004035	NAD binding pocket [chemical binding]; other site
405416004036	NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site
405416004037	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
405416004038	catalytic loop [active]
405416004039	iron binding site [ion binding]; other site
405416004040	enoyl-CoA hydratase-isomerase; Provisional; Region: PRK09674
405416004041	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
405416004042	substrate binding site [chemical binding]; other site
405416004043	oxyanion hole (OAH) forming residues; other site
405416004044	trimer interface [polypeptide binding]; other site
405416004045	enoyl-CoA hydratase; Provisional; Region: PRK08140
405416004046	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
405416004047	substrate binding site [chemical binding]; other site
405416004048	oxyanion hole (OAH) forming residues; other site
405416004049	trimer interface [polypeptide binding]; other site
405416004050	3-hydroxy-acyl-CoA dehydrogenase; Validated; Region: PRK08268
405416004051	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
405416004052	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
405416004053	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
405416004054	beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050
405416004055	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
405416004056	dimer interface [polypeptide binding]; other site
405416004057	active site
405416004058	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
405416004059	phenylacetate-CoA ligase; Region: PA_CoA_ligase; TIGR02155
405416004060	acyl-activating enzyme (AAE) consensus motif; other site
405416004061	AMP binding site [chemical binding]; other site
405416004062	active site
405416004063	CoA binding site [chemical binding]; other site
405416004064	PaaX-like protein; Region: PaaX; pfam07848
405416004065	phenylacetic acid degradation operon negative regulatory protein PaaX; Region: PaaX_trns_reg; TIGR02277
405416004066	PaaX-like protein C-terminal domain; Region: PaaX_C; pfam08223
405416004067	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
405416004068	putative trimer interface [polypeptide binding]; other site
405416004069	putative CoA binding site [chemical binding]; other site
405416004070	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
405416004071	CoenzymeA binding site [chemical binding]; other site
405416004072	subunit interaction site [polypeptide binding]; other site
405416004073	PHB binding site; other site
405416004074	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
405416004075	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
405416004076	putative active site [active]
405416004077	putative NTP binding site [chemical binding]; other site
405416004078	putative nucleic acid binding site [nucleotide binding]; other site
405416004079	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
405416004080	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
405416004081	Catalase-like heme-binding proteins similar to the uncharacterized srpA; Region: srpA_like; cd08153
405416004082	putative heme binding pocket [chemical binding]; other site
405416004083	Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038
405416004084	Uncharacterized conserved protein [Function unknown]; Region: COG5470
405416004085	Transcriptional regulators [Transcription]; Region: GntR; COG1802
405416004086	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
405416004087	DNA-binding site [nucleotide binding]; DNA binding site
405416004088	FCD domain; Region: FCD; cl11656
405416004089	Amino acid synthesis; Region: AA_synth; pfam06684
405416004090	Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303
405416004091	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
405416004092	Flavin reductase like domain; Region: Flavin_Reduct; smart00903
405416004093	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
405416004094	Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296
405416004095	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
405416004096	Uncharacterized Candidatus pelagibacter aldehyde dehydrogenase, DhaS-like; Region: ALDH_DhaS; cd07114
405416004097	NAD(P) binding site [chemical binding]; other site
405416004098	catalytic residues [active]
405416004099	Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456
405416004100	Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133
405416004101	Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103
405416004102	NAD(P) binding site [chemical binding]; other site
405416004103	catalytic residues [active]
405416004104	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
405416004105	Carboxymuconolactone decarboxylase family; Region: CMD; cl00460
405416004106	Transcriptional regulator [Transcription]; Region: LysR; COG0583
405416004107	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
405416004108	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_6; cd08475
405416004109	putative effector binding pocket; other site
405416004110	putative dimerization interface [polypeptide binding]; other site
405416004111	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
405416004112	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
405416004113	beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Region: pcaR_pcaU; TIGR02431
405416004114	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
405416004115	Bacterial transcriptional regulator; Region: IclR; pfam01614
405416004116	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
405416004117	4-hydroxybenzoate 3-monooxygenase; Validated; Region: PRK08243
405416004118	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
405416004119	transcriptional regulator protein; Region: phnR; TIGR03337
405416004120	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
405416004121	DNA-binding site [nucleotide binding]; DNA binding site
405416004122	UTRA domain; Region: UTRA; pfam07702
405416004123	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
405416004124	ABC-type thiamine transport system, periplasmic component [Coenzyme metabolism]; Region: TbpA; COG4143
405416004125	putative 2-aminoethylphosphonate ABC transporter, ATP-binding protein; Region: PhnT2; TIGR03265
405416004126	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
405416004127	Walker A/P-loop; other site
405416004128	ATP binding site [chemical binding]; other site
405416004129	Q-loop/lid; other site
405416004130	ABC transporter signature motif; other site
405416004131	Walker B; other site
405416004132	D-loop; other site
405416004133	H-loop/switch region; other site
405416004134	putative 2-aminoethylphosphonate ABC transporter, permease protein; Region: PhnU2; TIGR03262
405416004135	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
405416004136	dimer interface [polypeptide binding]; other site
405416004137	conserved gate region; other site
405416004138	putative PBP binding loops; other site
405416004139	ABC-ATPase subunit interface; other site
405416004140	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
405416004141	dimer interface [polypeptide binding]; other site
405416004142	conserved gate region; other site
405416004143	putative PBP binding loops; other site
405416004144	ABC-ATPase subunit interface; other site
405416004145	FAD dependent oxidoreductase TIGR03364; Region: HpnW_proposed
405416004146	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
405416004147	2-aminoethylphosphonate--pyruvate transaminase; Provisional; Region: PRK13479
405416004148	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
405416004149	catalytic residue [active]
405416004150	phosphonoacetaldehyde hydrolase; Provisional; Region: PRK13478
405416004151	benzoate transport; Region: 2A0115; TIGR00895
405416004152	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
405416004153	putative substrate translocation pore; other site
405416004154	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
405416004155	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
405416004156	active site
405416004157	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
405416004158	CoA-transferase family III; Region: CoA_transf_3; pfam02515
405416004159	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
405416004160	Transcriptional regulator [Transcription]; Region: IclR; COG1414
405416004161	Bacterial transcriptional regulator; Region: IclR; pfam01614
405416004162	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
405416004163	enoyl-CoA hydratase; Provisional; Region: PRK06688
405416004164	substrate binding site [chemical binding]; other site
405416004165	oxyanion hole (OAH) forming residues; other site
405416004166	trimer interface [polypeptide binding]; other site
405416004167	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
405416004168	Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070
405416004169	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
405416004170	FMN binding site [chemical binding]; other site
405416004171	substrate binding site [chemical binding]; other site
405416004172	putative catalytic residue [active]
405416004173	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
405416004174	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
405416004175	putative substrate translocation pore; other site
405416004176	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
405416004177	Transcriptional regulator [Transcription]; Region: IclR; COG1414
405416004178	Bacterial transcriptional regulator; Region: IclR; pfam01614
405416004179	acetyl-CoA acetyltransferase; Provisional; Region: PRK08131
405416004180	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
405416004181	dimer interface [polypeptide binding]; other site
405416004182	active site
405416004183	3-hydroxy-acyl-CoA dehydrogenase; Validated; Region: PRK08268
405416004184	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
405416004185	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
405416004186	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
405416004187	3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826
405416004188	classical (c) SDRs; Region: SDR_c; cd05233
405416004189	NAD(P) binding site [chemical binding]; other site
405416004190	active site
405416004191	enoyl-CoA hydratase; Provisional; Region: PRK08138
405416004192	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
405416004193	substrate binding site [chemical binding]; other site
405416004194	oxyanion hole (OAH) forming residues; other site
405416004195	trimer interface [polypeptide binding]; other site
405416004196	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
405416004197	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
405416004198	active site
405416004199	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
405416004200	benzoate transport; Region: 2A0115; TIGR00895
405416004201	putative substrate translocation pore; other site
405416004202	3-oxoacid CoA-transferase, A subunit; Region: pcaI_scoA_fam; TIGR02429
405416004203	3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428
405416004204	Maltoporin periplasmic N-terminal extension; Region: Sugarporin_N; pfam11471
405416004205	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
405416004206	Major Facilitator Superfamily; Region: MFS_1; pfam07690
405416004207	putative substrate translocation pore; other site
405416004208	Major Facilitator Superfamily; Region: MFS_1; pfam07690
405416004209	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
405416004210	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
405416004211	CoenzymeA binding site [chemical binding]; other site
405416004212	subunit interaction site [polypeptide binding]; other site
405416004213	PHB binding site; other site
405416004214	Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418
405416004215	acyl-CoA dehydrogenase; Provisional; Region: PTZ00456
405416004216	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
405416004217	active site
405416004218	Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806
405416004219	Thioesterase-like superfamily; Region: 4HBT_3; pfam13622
405416004220	indolepyruvate ferredoxin oxidoreductase; Validated; Region: PRK09193
405416004221	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
405416004222	dimer interface [polypeptide binding]; other site
405416004223	PYR/PP interface [polypeptide binding]; other site
405416004224	TPP binding site [chemical binding]; other site
405416004225	substrate binding site [chemical binding]; other site
405416004226	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629
405416004227	TPP-binding site [chemical binding]; other site
405416004228	Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014
405416004229	Transcriptional regulator [Transcription]; Region: LysR; COG0583
405416004230	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
405416004231	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
405416004232	putative effector binding pocket; other site
405416004233	dimerization interface [polypeptide binding]; other site
405416004234	Isopropylmalate/homocitrate/citramalate synthases [Amino acid transport and metabolism]; Region: LeuA; COG0119
405416004235	3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938
405416004236	active site
405416004237	catalytic residues [active]
405416004238	metal binding site [ion binding]; metal-binding site
405416004239	Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770
405416004240	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
405416004241	ATP-grasp domain; Region: ATP-grasp_4; cl17255
405416004242	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
405416004243	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
405416004244	carboxyltransferase (CT) interaction site; other site
405416004245	biotinylation site [posttranslational modification]; other site
405416004246	enoyl-CoA hydratase; Provisional; Region: PRK05995
405416004247	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
405416004248	substrate binding site [chemical binding]; other site
405416004249	oxyanion hole (OAH) forming residues; other site
405416004250	trimer interface [polypeptide binding]; other site
405416004251	3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820
405416004252	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
405416004253	isovaleryl-CoA dehydrogenase; Region: PLN02519
405416004254	Isovaleryl-CoA dehydrogenase; Region: IVD; cd01156
405416004255	substrate binding site [chemical binding]; other site
405416004256	FAD binding site [chemical binding]; other site
405416004257	catalytic base [active]
405416004258	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
405416004259	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
405416004260	AMP-binding domain protein; Validated; Region: PRK08315
405416004261	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
405416004262	Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917
405416004263	acyl-activating enzyme (AAE) consensus motif; other site
405416004264	putative AMP binding site [chemical binding]; other site
405416004265	putative active site [active]
405416004266	putative CoA binding site [chemical binding]; other site
405416004267	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
405416004268	S-adenosylmethionine binding site [chemical binding]; other site
405416004269	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
405416004270	SGNH_hydrolase subfamily, similar to the putative arylesterase/acylhydrolase from the rumen anaerobe Prevotella bryantii XynE. The P. bryantii XynE gene is located in a xylanase gene cluster. SGNH hydrolases are a diverse family of lipases and esterases; Region: XynE_like; cd01830
405416004271	active site
405416004272	catalytic triad [active]
405416004273	oxyanion hole [active]
405416004274	Transcriptional regulator [Transcription]; Region: LysR; COG0583
405416004275	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
405416004276	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
405416004277	putative effector binding pocket; other site
405416004278	dimerization interface [polypeptide binding]; other site
405416004279	The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia.  This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775
405416004280	Competence-damaged protein; Region: CinA; pfam02464
405416004281	hydroperoxidase II; Provisional; Region: katE; PRK11249
405416004282	Clade 2 of the heme-binding enzyme catalase; Region: catalase_clade_2; cd08155
405416004283	tetramer interface [polypeptide binding]; other site
405416004284	heme binding pocket [chemical binding]; other site
405416004285	Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132
405416004286	domain interactions; other site
405416004287	short chain dehydrogenase; Provisional; Region: PRK06701
405416004288	classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355
405416004289	NAD binding site [chemical binding]; other site
405416004290	metal binding site [ion binding]; metal-binding site
405416004291	active site
405416004292	Stress-induced bacterial acidophilic repeat motif; Region: KGG; pfam10685
405416004293	SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974
405416004294	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
405416004295	Catalytic site [active]
405416004296	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
405416004297	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
405416004298	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
405416004299	putative DNA binding site [nucleotide binding]; other site
405416004300	putative Zn2+ binding site [ion binding]; other site
405416004301	AsnC family; Region: AsnC_trans_reg; pfam01037
405416004302	Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456
405416004303	Na binding site [ion binding]; other site
405416004304	Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456
405416004305	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
405416004306	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
405416004307	dimer interface [polypeptide binding]; other site
405416004308	phosphorylation site [posttranslational modification]
405416004309	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
405416004310	ATP binding site [chemical binding]; other site
405416004311	Mg2+ binding site [ion binding]; other site
405416004312	G-X-G motif; other site
405416004313	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
405416004314	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
405416004315	active site
405416004316	phosphorylation site [posttranslational modification]
405416004317	intermolecular recognition site; other site
405416004318	dimerization interface [polypeptide binding]; other site
405416004319	Response regulator receiver domain; Region: Response_reg; pfam00072
405416004320	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
405416004321	active site
405416004322	phosphorylation site [posttranslational modification]
405416004323	intermolecular recognition site; other site
405416004324	dimerization interface [polypeptide binding]; other site
405416004325	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
405416004326	DNA binding residues [nucleotide binding]
405416004327	dimerization interface [polypeptide binding]; other site
405416004328	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
405416004329	Coenzyme A binding pocket [chemical binding]; other site
405416004330	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
405416004331	dimer interface [polypeptide binding]; other site
405416004332	conserved gate region; other site
405416004333	putative PBP binding loops; other site
405416004334	ABC-ATPase subunit interface; other site
405416004335	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
405416004336	dimer interface [polypeptide binding]; other site
405416004337	conserved gate region; other site
405416004338	putative PBP binding loops; other site
405416004339	ABC-ATPase subunit interface; other site
405416004340	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
405416004341	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
405416004342	Walker A/P-loop; other site
405416004343	ATP binding site [chemical binding]; other site
405416004344	Q-loop/lid; other site
405416004345	ABC transporter signature motif; other site
405416004346	Walker B; other site
405416004347	D-loop; other site
405416004348	H-loop/switch region; other site
405416004349	Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062
405416004350	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
405416004351	substrate binding pocket [chemical binding]; other site
405416004352	membrane-bound complex binding site; other site
405416004353	hinge residues; other site
405416004354	Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062
405416004355	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
405416004356	substrate binding pocket [chemical binding]; other site
405416004357	membrane-bound complex binding site; other site
405416004358	hinge residues; other site
405416004359	Transcriptional regulator [Transcription]; Region: LysR; COG0583
405416004360	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
405416004361	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
405416004362	putative effector binding pocket; other site
405416004363	dimerization interface [polypeptide binding]; other site
405416004364	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
405416004365	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
405416004366	Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453
405416004367	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
405416004368	catalytic residue [active]
405416004369	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
405416004370	trimer interface [polypeptide binding]; other site
405416004371	active site
405416004372	substrate binding site [chemical binding]; other site
405416004373	CoA binding site [chemical binding]; other site
405416004374	Member of the Rhodanese Homology Domain superfamily, subgroup 1. This CD includes the putative rhodanese-related sulfurtransferases of several uncharacterized proteins; Region: RHOD_1; cd01522
405416004375	active site residue [active]
405416004376	short chain dehydrogenase; Provisional; Region: PRK12937
405416004377	tetrahydroxynaphthalene/trihydroxynaphthalene reductase-like, classical (c) SDRs; Region: THN_reductase-like_SDR_c; cd05362
405416004378	NADP binding site [chemical binding]; other site
405416004379	homodimer interface [polypeptide binding]; other site
405416004380	active site
405416004381	substrate binding site [chemical binding]; other site
405416004382	Transcriptional regulator [Transcription]; Region: LysR; COG0583
405416004383	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
405416004384	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472
405416004385	putative effector binding pocket; other site
405416004386	putative dimerization interface [polypeptide binding]; other site
405416004387	putative S-transferase; Provisional; Region: PRK11752
405416004388	GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048
405416004389	C-terminal domain interface [polypeptide binding]; other site
405416004390	GSH binding site (G-site) [chemical binding]; other site
405416004391	dimer interface [polypeptide binding]; other site
405416004392	C-terminal, alpha helical domain of Escherichia coli Yghu Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YghU_like; cd10292
405416004393	dimer interface [polypeptide binding]; other site
405416004394	N-terminal domain interface [polypeptide binding]; other site
405416004395	active site
405416004396	glutathione S-transferase; Provisional; Region: PRK15113
405416004397	Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of  glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570
405416004398	C-terminal domain interface [polypeptide binding]; other site
405416004399	GSH binding site (G-site) [chemical binding]; other site
405416004400	dimer interface [polypeptide binding]; other site
405416004401	C-terminal, alpha helical domain of an unknown subfamily 4 of Glutathione S-transferases; Region: GST_C_4; cd03195
405416004402	putative dimer interface [polypeptide binding]; other site
405416004403	N-terminal domain interface [polypeptide binding]; other site
405416004404	putative substrate binding pocket (H-site) [chemical binding]; other site
405416004405	Transcriptional regulator [Transcription]; Region: LysR; COG0583
405416004406	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
405416004407	The C-terminal substrate binding domain of LysR-like transcriptional regulator CidR, contains the type 2 periplasmic binding fold; Region: PBP2_CidR; cd08438
405416004408	putative dimerization interface [polypeptide binding]; other site
405416004409	LrgA family; Region: LrgA; cl00608
405416004410	Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346
405416004411	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
405416004412	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
405416004413	DNA-binding site [nucleotide binding]; DNA binding site
405416004414	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
405416004415	pyridoxal 5'-phosphate binding site [chemical binding]; other site
405416004416	homodimer interface [polypeptide binding]; other site
405416004417	catalytic residue [active]
405416004418	Transcriptional regulator [Transcription]; Region: PaiB; COG2808
405416004419	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
405416004420	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
405416004421	Major Facilitator Superfamily; Region: MFS_1; pfam07690
405416004422	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
405416004423	putative substrate translocation pore; other site
405416004424	malonate decarboxylase, alpha subunit; Region: mdcA; TIGR01110
405416004425	triphosphoribosyl-dephospho-CoA synthase; Validated; Region: PRK01237
405416004426	malonate decarboxylase subunit delta; Provisional; Region: PRK01220
405416004427	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189
405416004428	malonate decarboxylase, gamma subunit; Region: malonate_gamma; TIGR03134
405416004429	phosphoribosyl-dephospho-CoA transferase; Provisional; Region: PRK01293
405416004430	Phosphoribosyl-dephospho-CoA transferase MdcG; Region: MdcG; pfam10620
405416004431	malonate decarboxylase, epsilon subunit; Region: malonate_mdcH; TIGR03131
405416004432	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
405416004433	Malonate transporter MadL subunit; Region: MadL; cl04273
405416004434	malonate transporter, MadM subunit; Region: malonate_madM; TIGR00808
405416004435	Transcriptional regulator [Transcription]; Region: LysR; COG0583
405416004436	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
405416004437	The C-terminal substrate-binding domian of LysR-type transcriptional regulator MdcR, which involved in the malonate catabolism contains the type 2 periplasmic binding fold; Region: PBP2_MdcR; cd08416
405416004438	putative dimerization interface [polypeptide binding]; other site
405416004439	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
405416004440	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
405416004441	DNA-binding site [nucleotide binding]; DNA binding site
405416004442	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
405416004443	pyridoxal 5'-phosphate binding site [chemical binding]; other site
405416004444	homodimer interface [polypeptide binding]; other site
405416004445	catalytic residue [active]
405416004446	Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322
405416004447	cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219
405416004448	Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654
405416004449	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
405416004450	sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022
405416004451	active site
405416004452	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
405416004453	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
405416004454	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
405416004455	Sugar (and other) transporter; Region: Sugar_tr; pfam00083
405416004456	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
405416004457	putative substrate translocation pore; other site
405416004458	taurine ABC transporter, periplasmic binding protein; Region: taurine_ABC_bnd; TIGR01729
405416004459	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
405416004460	substrate binding pocket [chemical binding]; other site
405416004461	membrane-bound complex binding site; other site
405416004462	hinge residues; other site
405416004463	taurine transporter ATP-binding subunit; Provisional; Region: tauB; PRK11248
405416004464	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
405416004465	Walker A/P-loop; other site
405416004466	ATP binding site [chemical binding]; other site
405416004467	Q-loop/lid; other site
405416004468	ABC transporter signature motif; other site
405416004469	Walker B; other site
405416004470	D-loop; other site
405416004471	H-loop/switch region; other site
405416004472	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
405416004473	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
405416004474	dimer interface [polypeptide binding]; other site
405416004475	conserved gate region; other site
405416004476	putative PBP binding loops; other site
405416004477	ABC-ATPase subunit interface; other site
405416004478	taurine dioxygenase; Reviewed; Region: tauD; PRK09553
405416004479	Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175
405416004480	active site
405416004481	iron coordination sites [ion binding]; other site
405416004482	substrate binding pocket [chemical binding]; other site
405416004483	Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518
405416004484	uncharacterized nucleobase-cation-symport-1 (NCS1) transporter subfamily; solute-binding domain; Region: SLC-NCS1sbd_u1; cd11555
405416004485	Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133
405416004486	Na binding site [ion binding]; other site
405416004487	putative substrate binding site [chemical binding]; other site
405416004488	Transcriptional regulators [Transcription]; Region: GntR; COG1802
405416004489	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
405416004490	DNA-binding site [nucleotide binding]; DNA binding site
405416004491	FCD domain; Region: FCD; pfam07729
405416004492	Transcriptional regulator [Transcription]; Region: LysR; COG0583
405416004493	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
405416004494	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
405416004495	putative effector binding pocket; other site
405416004496	dimerization interface [polypeptide binding]; other site
405416004497	YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012
405416004498	Isochorismatase family; Region: Isochorismatase; pfam00857
405416004499	catalytic triad [active]
405416004500	dimer interface [polypeptide binding]; other site
405416004501	conserved cis-peptide bond; other site
405416004502	Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574
405416004503	YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300
405416004504	active site
405416004505	Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034
405416004506	ArsC family; Region: ArsC; pfam03960
405416004507	catalytic residues [active]
405416004508	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
405416004509	dimerization interface [polypeptide binding]; other site
405416004510	putative DNA binding site [nucleotide binding]; other site
405416004511	putative Zn2+ binding site [ion binding]; other site
405416004512	Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798
405416004513	arsenical-resistance protein; Region: acr3; TIGR00832
405416004514	Transcriptional regulator [Transcription]; Region: LysR; COG0583
405416004515	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
405416004516	The C-terminal substrate binding domain of LysR-type transcrptional regulator BudR, which is responsible for activation of the expression of the butanediol operon genes; contains the type 2 periplasmic binding fold; Region: PBP2_BudR; cd08451
405416004517	putative dimerization interface [polypeptide binding]; other site
405416004518	putative substrate binding pocket [chemical binding]; other site
405416004519	Chromate transporter; Region: Chromate_transp; pfam02417
405416004520	Chromate transporter; Region: Chromate_transp; pfam02417
405416004521	alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317
405416004522	Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974
405416004523	catalytic residue [active]
405416004524	TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026
405416004525	catalytic residues [active]
405416004526	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
405416004527	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
405416004528	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
405416004529	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
405416004530	TPR motif; other site
405416004531	binding surface
405416004532	serine O-acetyltransferase; Region: cysE; TIGR01172
405416004533	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
405416004534	trimer interface [polypeptide binding]; other site
405416004535	active site
405416004536	substrate binding site [chemical binding]; other site
405416004537	CoA binding site [chemical binding]; other site
405416004538	rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565
405416004539	SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307
405416004540	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433
405416004541	DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673
405416004542	putative active site [active]
405416004543	putative PHP Thumb interface [polypeptide binding]; other site
405416004544	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
405416004545	generic binding surface I; other site
405416004546	generic binding surface II; other site
405416004547	Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964
405416004548	active site
405416004549	homodimer interface [polypeptide binding]; other site
405416004550	homotetramer interface [polypeptide binding]; other site
405416004551	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
405416004552	Sodium:dicarboxylate symporter family; Region: SDF; cl00573
405416004553	aminotransferase AlaT; Validated; Region: PRK09265
405416004554	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
405416004555	pyridoxal 5'-phosphate binding site [chemical binding]; other site
405416004556	homodimer interface [polypeptide binding]; other site
405416004557	catalytic residue [active]
405416004558	methionine sulfoxide reductase B; Provisional; Region: PRK00222
405416004559	SelR domain; Region: SelR; pfam01641
405416004560	Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340
405416004561	catalytic residues [active]
405416004562	dimer interface [polypeptide binding]; other site
405416004563	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
405416004564	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
405416004565	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
405416004566	LysE type translocator; Region: LysE; cl00565
405416004567	succinyldiaminopimelate transaminase; Provisional; Region: PRK09147
405416004568	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
405416004569	pyridoxal 5'-phosphate binding site [chemical binding]; other site
405416004570	homodimer interface [polypeptide binding]; other site
405416004571	catalytic residue [active]
405416004572	PII uridylyl-transferase; Provisional; Region: glnD; PRK00275
405416004573	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
405416004574	metal binding triad; other site
405416004575	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
405416004576	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
405416004577	Zn2+ binding site [ion binding]; other site
405416004578	Mg2+ binding site [ion binding]; other site
405416004579	ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900
405416004580	C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899
405416004581	phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288
405416004582	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
405416004583	ATP-grasp domain; Region: ATP-grasp; pfam02222
405416004584	5-carboxymethyl-2-hydroxymuconate isomerase (CHMI) is a trimeric enzyme catalyzing the isomerization of the unsaturated ketone 5-(carboxymethyl)-2-hydroxymuconate to 5-(carboxymethyl)-2-oxo-3-hexene-1,6-dionate. This is one step in the...; Region: CHMI; cl01268
405416004585	trimer interface [polypeptide binding]; other site
405416004586	putative substrate binding pocket [chemical binding]; other site
405416004587	4-Oxalocrotonate Tautomerase:  Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235
405416004588	active site 1 [active]
405416004589	dimer interface [polypeptide binding]; other site
405416004590	hexamer interface [polypeptide binding]; other site
405416004591	active site 2 [active]
405416004592	putative L-valine exporter; Provisional; Region: PRK10408
405416004593	AzlC protein; Region: AzlC; cl00570
405416004594	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
405416004595	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
405416004596	ligand binding site [chemical binding]; other site
405416004597	flexible hinge region; other site
405416004598	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
405416004599	putative switch regulator; other site
405416004600	non-specific DNA interactions [nucleotide binding]; other site
405416004601	DNA binding site [nucleotide binding]
405416004602	sequence specific DNA binding site [nucleotide binding]; other site
405416004603	putative cAMP binding site [chemical binding]; other site
405416004604	Predicted membrane protein [Function unknown]; Region: COG4539
405416004605	GTP-binding protein YchF; Reviewed; Region: PRK09601
405416004606	YchF GTPase; Region: YchF; cd01900
405416004607	G1 box; other site
405416004608	GTP/Mg2+ binding site [chemical binding]; other site
405416004609	Switch I region; other site
405416004610	G2 box; other site
405416004611	Switch II region; other site
405416004612	G3 box; other site
405416004613	G4 box; other site
405416004614	G5 box; other site
405416004615	TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867
405416004616	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
405416004617	dimer interface [polypeptide binding]; other site
405416004618	conserved gate region; other site
405416004619	ABC-ATPase subunit interface; other site
405416004620	DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153
405416004621	ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258
405416004622	Walker A/P-loop; other site
405416004623	ATP binding site [chemical binding]; other site
405416004624	Q-loop/lid; other site
405416004625	ABC transporter signature motif; other site
405416004626	Walker B; other site
405416004627	D-loop; other site
405416004628	H-loop/switch region; other site
405416004629	This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930
405416004630	NLPA lipoprotein; Region: Lipoprotein_9; pfam03180
405416004631	NLPA lipoprotein; Region: Lipoprotein_9; pfam03180
405416004632	FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860
405416004633	nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095
405416004634	active site
405416004635	non-prolyl cis peptide bond; other site
405416004636	sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022
405416004637	Dibenzothiophene (DBT) desulfurization enzyme C; Region: DszC; cd01163
405416004638	Flavin binding site [chemical binding]; other site
405416004639	sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022
405416004640	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
405416004641	active site
405416004642	Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of  glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570
405416004643	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
405416004644	C-terminal domain interface [polypeptide binding]; other site
405416004645	GSH binding site (G-site) [chemical binding]; other site
405416004646	dimer interface [polypeptide binding]; other site
405416004647	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776
405416004648	N-terminal domain interface [polypeptide binding]; other site
405416004649	glutamate and aspartate transporter subunit; Provisional; Region: PRK10797
405416004650	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
405416004651	substrate binding pocket [chemical binding]; other site
405416004652	membrane-bound complex binding site; other site
405416004653	hinge residues; other site
405416004654	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
405416004655	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
405416004656	dimer interface [polypeptide binding]; other site
405416004657	conserved gate region; other site
405416004658	putative PBP binding loops; other site
405416004659	ABC-ATPase subunit interface; other site
405416004660	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
405416004661	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
405416004662	dimer interface [polypeptide binding]; other site
405416004663	conserved gate region; other site
405416004664	putative PBP binding loops; other site
405416004665	ABC-ATPase subunit interface; other site
405416004666	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
405416004667	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
405416004668	Walker A/P-loop; other site
405416004669	ATP binding site [chemical binding]; other site
405416004670	Q-loop/lid; other site
405416004671	ABC transporter signature motif; other site
405416004672	Walker B; other site
405416004673	D-loop; other site
405416004674	H-loop/switch region; other site
405416004675	DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563
405416004676	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
405416004677	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
405416004678	putative DNA binding site [nucleotide binding]; other site
405416004679	putative Zn2+ binding site [ion binding]; other site
405416004680	AsnC family; Region: AsnC_trans_reg; pfam01037
405416004681	hypothetical protein; Validated; Region: PRK00110
405416004682	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown ABO13168; Region: LPLAT_ABO13168-like; cd07988
405416004683	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
405416004684	putative acyl-acceptor binding pocket; other site
405416004685	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
405416004686	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
405416004687	Domain of unknown function (DUF4102); Region: DUF4102; pfam13356
405416004688	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
405416004689	active site
405416004690	catalytic residues [active]
405416004691	Int/Topo IB signature motif; other site
405416004692	DNA binding site [nucleotide binding]
405416004693	Transcriptional regulator [Transcription]; Region: LysR; COG0583
405416004694	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
405416004695	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
405416004696	dimerization interface [polypeptide binding]; other site
405416004697	Predicted membrane protein [Function unknown]; Region: COG4125
405416004698	Bacterial Transmembrane Pair family; Region: BTP; pfam05232
405416004699	Bacterial Transmembrane Pair family; Region: BTP; pfam05232
405416004700	Purine-cytosine permease and related proteins [Nucleotide transport and metabolism]; Region: CodB; COG1457
405416004701	Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133
405416004702	Na binding site [ion binding]; other site
405416004703	EamA-like transporter family; Region: EamA; pfam00892
405416004704	Transcriptional regulator [Transcription]; Region: LysR; COG0583
405416004705	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
405416004706	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
405416004707	dimerization interface [polypeptide binding]; other site
405416004708	putative major fimbrial protein SthE; Provisional; Region: PRK15292
405416004709	P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539
405416004710	P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188
405416004711	PapC N-terminal domain; Region: PapC_N; pfam13954
405416004712	Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577
405416004713	PapC C-terminal domain; Region: PapC_C; pfam13953
405416004714	P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121
405416004715	Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345
405416004716	Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753
405416004717	P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539
405416004718	biotin synthase; Provisional; Region: PRK15108
405416004719	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
405416004720	FeS/SAM binding site; other site
405416004721	Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876
405416004722	epoxyqueuosine reductase; Region: TIGR00276
405416004723	Domain of unknown function (DUF1730); Region: DUF1730; pfam08331
405416004724	putative carbohydrate kinase; Provisional; Region: PRK10565
405416004725	YjeF-related protein N-terminus; Region: YjeF_N; pfam03853
405416004726	B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171
405416004727	putative substrate binding site [chemical binding]; other site
405416004728	putative ATP binding site [chemical binding]; other site
405416004729	Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529
405416004730	active site
405416004731	putative DNA-binding cleft [nucleotide binding]; other site
405416004732	dimer interface [polypeptide binding]; other site
405416004733	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
405416004734	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
405416004735	non-specific DNA binding site [nucleotide binding]; other site
405416004736	salt bridge; other site
405416004737	sequence-specific DNA binding site [nucleotide binding]; other site
405416004738	Cupin domain; Region: Cupin_2; cl17218
405416004739	Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247
405416004740	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
405416004741	Beta-lactamase class D [Defense mechanisms]; Region: COG2602
405416004742	FxsA cytoplasmic membrane protein; Region: FxsA; pfam04186
405416004743	N2,N2-dimethylguanosine tRNA methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TRM1; COG1867
405416004744	S-adenosylmethionine synthetase; Validated; Region: PRK05250
405416004745	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
405416004746	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
405416004747	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
405416004748	transketolase; Reviewed; Region: PRK12753
405416004749	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
405416004750	TPP-binding site [chemical binding]; other site
405416004751	dimer interface [polypeptide binding]; other site
405416004752	ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192
405416004753	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
405416004754	PYR/PP interface [polypeptide binding]; other site
405416004755	dimer interface [polypeptide binding]; other site
405416004756	TPP binding site [chemical binding]; other site
405416004757	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
405416004758	OsmC-like protein; Region: OsmC; pfam02566
405416004759	Uncharacterized conserved protein [Function unknown]; Region: COG2353
405416004760	Lecithin retinol acyltransferase; Region: LRAT; pfam04970
405416004761	Predicted periplasmic protein [Function unknown]; Region: COG3698
405416004762	Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992
405416004763	tRNA (uracil-5-)-methyltransferase; Validated; Region: PRK05031
405416004764	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
405416004765	S-adenosylmethionine binding site [chemical binding]; other site
405416004766	Uncharacterized protein family (UPF0157); Region: UPF0157; cl00987
405416004767	bifunctional proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: PRK11905
405416004768	Proline dehydrogenase [Amino acid transport and metabolism]; Region: PutA; COG0506
405416004769	Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125
405416004770	Glutamate binding site [chemical binding]; other site
405416004771	NAD binding site [chemical binding]; other site
405416004772	catalytic residues [active]
405416004773	leucine-responsive transcriptional regulator; Provisional; Region: PRK11169
405416004774	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
405416004775	dimerization interface [polypeptide binding]; other site
405416004776	putative DNA binding site [nucleotide binding]; other site
405416004777	putative Zn2+ binding site [ion binding]; other site
405416004778	AsnC family; Region: AsnC_trans_reg; pfam01037
405416004779	Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475
405416004780	Na binding site [ion binding]; other site
405416004781	NAD-dependent deacetylase; Provisional; Region: PRK00481
405416004782	SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412
405416004783	NAD+ binding site [chemical binding]; other site
405416004784	substrate binding site [chemical binding]; other site
405416004785	Zn binding site [ion binding]; other site
405416004786	Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848
405416004787	lipoyl attachment site [posttranslational modification]; other site
405416004788	Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625
405416004789	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
405416004790	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
405416004791	YdeM is a Bacillus subtilis protein that belongs to a family of prokaryotic proteins of unkown function.  YdeM has sequence similarity to the hot-dog fold of (R)-specific enoyl-CoA hydratase.   Other enzymes with this fold include the peroxisomal...; Region: YdeM; cd03454
405416004792	putative active site [active]
405416004793	putative catalytic site [active]
405416004794	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
405416004795	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
405416004796	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
405416004797	Walker A/P-loop; other site
405416004798	ATP binding site [chemical binding]; other site
405416004799	Q-loop/lid; other site
405416004800	ABC transporter signature motif; other site
405416004801	Walker B; other site
405416004802	D-loop; other site
405416004803	H-loop/switch region; other site
405416004804	Uncharacterized protein conserved in bacteria (DUF2058); Region: DUF2058; pfam09831
405416004805	Protein of unknown function (DUF1275); Region: DUF1275; pfam06912
405416004806	serine/threonine transporter SstT; Provisional; Region: PRK13628
405416004807	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
405416004808	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
405416004809	dimerization interface [polypeptide binding]; other site
405416004810	putative DNA binding site [nucleotide binding]; other site
405416004811	putative Zn2+ binding site [ion binding]; other site
405416004812	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
405416004813	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
405416004814	Cupin superfamily protein; Region: Cupin_4; pfam08007
405416004815	Cupin-like domain; Region: Cupin_8; pfam13621
405416004816	Maf-like protein; Region: Maf; pfam02545
405416004817	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
405416004818	active site
405416004819	dimer interface [polypeptide binding]; other site
405416004820	Uncharacterized protein conserved in bacteria (DUF2237); Region: DUF2237; pfam09996
405416004821	phosphoglycerate kinase; Provisional; Region: pgk; PRK00073
405416004822	Phosphoglycerate kinase; Region: PGK; pfam00162
405416004823	substrate binding site [chemical binding]; other site
405416004824	hinge regions; other site
405416004825	ADP binding site [chemical binding]; other site
405416004826	catalytic site [active]
405416004827	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947
405416004828	fructose-bisphosphate aldolase; Provisional; Region: PRK09197
405416004829	intersubunit interface [polypeptide binding]; other site
405416004830	active site
405416004831	zinc binding site [ion binding]; other site
405416004832	Na+ binding site [ion binding]; other site
405416004833	peptidyl-prolyl cis-trans isomerase SurA; Provisional; Region: PRK10770
405416004834	SurA N-terminal domain; Region: SurA_N; pfam09312
405416004835	PPIC-type PPIASE domain; Region: Rotamase_2; cl08278
405416004836	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
405416004837	Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452
405416004838	OstA-like protein; Region: OstA; cl00844
405416004839	Organic solvent tolerance protein; Region: OstA_C; pfam04453
405416004840	Predicted phosphotransferase related to Ser/Thr protein kinases [General function prediction only]; Region: COG3178
405416004841	Phosphotransferase enzyme family; Region: APH; pfam01636
405416004842	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
405416004843	NTP_transferase_like_1 is a member of the nucleotidyl transferase family; Region: NTP_transferase_like_1; cd06422
405416004844	Substrate binding site; other site
405416004845	metal-binding site
405416004846	16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107
405416004847	rRNA small subunit methyltransferase G; Region: GidB; pfam02527
405416004848	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
405416004849	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
405416004850	P-loop; other site
405416004851	Magnesium ion binding site [ion binding]; other site
405416004852	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
405416004853	Magnesium ion binding site [ion binding]; other site
405416004854	ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180
405416004855	ParB-like nuclease domain; Region: ParB; smart00470
405416004856	Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811
405416004857	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
405416004858	Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472
405416004859	lipid A export permease/ATP-binding protein MsbA; Region: MsbA_lipidA; TIGR02203
405416004860	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
405416004861	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
405416004862	Walker A/P-loop; other site
405416004863	ATP binding site [chemical binding]; other site
405416004864	Q-loop/lid; other site
405416004865	ABC transporter signature motif; other site
405416004866	Walker B; other site
405416004867	D-loop; other site
405416004868	H-loop/switch region; other site
405416004869	Tetraacyldisaccharide-1-P 4'-kinase [Cell envelope biogenesis, outer membrane]; Region: LpxK; COG1663
405416004870	Tetraacyldisaccharide-1-P 4'-kinase; Region: LpxK; pfam02606
405416004871	3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450
405416004872	CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517
405416004873	Ligand binding site; other site
405416004874	oligomer interface; other site
405416004875	DNA polymerase III subunit delta'; Validated; Region: PRK05707
405416004876	PilZ domain; Region: PilZ; cl01260
405416004877	Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099
405416004878	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
405416004879	active site
405416004880	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
405416004881	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
405416004882	Type II secretion system (T2SS), protein I; Region: T2SI; pfam02501
405416004883	prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532
405416004884	Type II secretion system (T2SS), protein J; Region: T2SJ; pfam11612
405416004885	Type II secretion system (T2SS), protein K; Region: T2SK; pfam03934
405416004886	6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242
405416004887	Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027
405416004888	ligand binding site [chemical binding]; other site
405416004889	active site
405416004890	UGI interface [polypeptide binding]; other site
405416004891	catalytic site [active]
405416004892	3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617
405416004893	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
405416004894	substrate binding site [chemical binding]; other site
405416004895	oxyanion hole (OAH) forming residues; other site
405416004896	trimer interface [polypeptide binding]; other site
405416004897	2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766
405416004898	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
405416004899	nucleoside/Zn binding site; other site
405416004900	dimer interface [polypeptide binding]; other site
405416004901	catalytic motif [active]
405416004902	Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821
405416004903	putative hydrophobic ligand binding site [chemical binding]; other site
405416004904	protein interface [polypeptide binding]; other site
405416004905	gate; other site
405416004906	cytidylate kinase; Provisional; Region: cmk; PRK00023
405416004907	Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020
405416004908	CMP-binding site; other site
405416004909	The sites determining sugar specificity; other site
405416004910	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
405416004911	RNA binding site [nucleotide binding]; other site
405416004912	30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676
405416004913	S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688
405416004914	RNA binding site [nucleotide binding]; other site
405416004915	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
405416004916	RNA binding site [nucleotide binding]; other site
405416004917	S1_RPS1_repeat_ec5: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec5; cd05690
405416004918	RNA binding site [nucleotide binding]; other site
405416004919	S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec6; cd05691
405416004920	RNA binding site [nucleotide binding]; other site
405416004921	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
405416004922	IHF dimer interface [polypeptide binding]; other site
405416004923	IHF - DNA interface [nucleotide binding]; other site
405416004924	Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725
405416004925	active site
405416004926	dimer interface [polypeptide binding]; other site
405416004927	Membrane protein of unknown function (DUF340); Region: DUF340; cl01028
405416004928	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
405416004929	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
405416004930	Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625
405416004931	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
405416004932	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
405416004933	Predicted ATPase [General function prediction only]; Region: COG1485
405416004934	malate synthase G; Provisional; Region: PRK02999
405416004935	active site
405416004936	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
405416004937	Coenzyme A binding pocket [chemical binding]; other site
405416004938	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
405416004939	Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472
405416004940	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
405416004941	Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472
405416004942	Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811
405416004943	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
405416004944	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
405416004945	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
405416004946	N-terminal plug; other site
405416004947	ligand-binding site [chemical binding]; other site
405416004948	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_18; cd08505
405416004949	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
405416004950	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_18; cd08505
405416004951	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
405416004952	Peptidase M3 Thimet oligopeptidase (TOP) also includes neurolysin; Region: M3A_TOP; cd06455
405416004953	Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339
405416004954	active site
405416004955	Zn binding site [ion binding]; other site
405416004956	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
405416004957	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
405416004958	dimer interface [polypeptide binding]; other site
405416004959	conserved gate region; other site
405416004960	putative PBP binding loops; other site
405416004961	ABC-ATPase subunit interface; other site
405416004962	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
405416004963	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
405416004964	dimer interface [polypeptide binding]; other site
405416004965	conserved gate region; other site
405416004966	putative PBP binding loops; other site
405416004967	ABC-ATPase subunit interface; other site
405416004968	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
405416004969	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
405416004970	Walker A/P-loop; other site
405416004971	ATP binding site [chemical binding]; other site
405416004972	Q-loop/lid; other site
405416004973	ABC transporter signature motif; other site
405416004974	Walker B; other site
405416004975	D-loop; other site
405416004976	H-loop/switch region; other site
405416004977	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
405416004978	Walker A/P-loop; other site
405416004979	ATP binding site [chemical binding]; other site
405416004980	Q-loop/lid; other site
405416004981	ABC transporter signature motif; other site
405416004982	Walker B; other site
405416004983	D-loop; other site
405416004984	H-loop/switch region; other site
405416004985	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
405416004986	Uncharacterized ACR, COG2135; Region: DUF159; pfam02586
405416004987	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
405416004988	CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638
405416004989	active site
405416004990	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
405416004991	catalytic core [active]
405416004992	30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239
405416004993	CC3(TIP30)-like, atypical (a) SDRs; Region: CC3_like_SDR_a; cd05250
405416004994	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
405416004995	NAD binding site [chemical binding]; other site
405416004996	active site
405416004997	ribonuclease activity regulator protein RraA; Provisional; Region: PRK09372
405416004998	GST_N family, 2 repeats of the N-terminal domain of soluble GSTs (2 GST_N) subfamily; composed of uncharacterized proteins. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a...; Region: GST_N_2GST_N; cd03041
405416004999	putative C-terminal domain interface [polypeptide binding]; other site
405416005000	putative GSH binding site (G-site) [chemical binding]; other site
405416005001	putative dimer interface [polypeptide binding]; other site
405416005002	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
405416005003	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
405416005004	Dyp-type peroxidase family; Region: Dyp_perox; cl01067
405416005005	Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197
405416005006	CarD-like/TRCF domain; Region: CarD_TRCF; smart01058
405416005007	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
405416005008	ATP binding site [chemical binding]; other site
405416005009	putative Mg++ binding site [ion binding]; other site
405416005010	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
405416005011	nucleotide binding region [chemical binding]; other site
405416005012	ATP-binding site [chemical binding]; other site
405416005013	This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982
405416005014	HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228
405416005015	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
405416005016	cyclase homology domain; Region: CHD; cd07302
405416005017	nucleotidyl binding site; other site
405416005018	metal binding site [ion binding]; metal-binding site
405416005019	dimer interface [polypeptide binding]; other site
405416005020	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
405416005021	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
405416005022	catalytic loop [active]
405416005023	iron binding site [ion binding]; other site
405416005024	chaperone protein HscA; Provisional; Region: hscA; PRK05183
405416005025	Nucleotide-binding domain of HscA and similar proteins; Region: HscA_like_NBD; cd10236
405416005026	nucleotide binding site [chemical binding]; other site
405416005027	putative NEF/HSP70 interaction site [polypeptide binding]; other site
405416005028	SBD interface [polypeptide binding]; other site
405416005029	co-chaperone HscB; Provisional; Region: hscB; PRK05014
405416005030	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
405416005031	HSP70 interaction site [polypeptide binding]; other site
405416005032	HSCB C-terminal oligomerisation domain; Region: HSCB_C; pfam07743
405416005033	Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400
405416005034	NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822
405416005035	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664
405416005036	trimerization site [polypeptide binding]; other site
405416005037	active site
405416005038	cysteine desulfurase; Provisional; Region: PRK14012
405416005039	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
405416005040	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
405416005041	catalytic residue [active]
405416005042	Transcriptional regulator; Region: Rrf2; cl17282
405416005043	Rrf2 family protein; Region: rrf2_super; TIGR00738
405416005044	Poly(hydroxyalcanoate) granule associated protein (phasin); Region: Phasin; pfam05597
405416005045	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
405416005046	IHF dimer interface [polypeptide binding]; other site
405416005047	IHF - DNA interface [nucleotide binding]; other site
405416005048	periplasmic folding chaperone; Provisional; Region: PRK10788
405416005049	SurA N-terminal domain; Region: SurA_N_3; cl07813
405416005050	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
405416005051	Cupin; Region: Cupin_6; pfam12852
405416005052	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
405416005053	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
405416005054	Alkane hydroxylase is a bacterial, integral-membrane di-iron enzyme that shares a requirement for iron and oxygen for activity similar to that of the non-heme integral-membrane acyl coenzyme A (CoA) desaturases and acyl lipid desaturases. The alk genes...; Region: Alkane-hydroxylase; cd03512
405416005055	Fatty acid desaturase; Region: FA_desaturase; pfam00487
405416005056	Di-iron ligands [ion binding]; other site
405416005057	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
405416005058	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
405416005059	active site
405416005060	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
405416005061	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
405416005062	active site
405416005063	Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661
405416005064	ABC1 family; Region: ABC1; cl17513
405416005065	This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002
405416005066	putative deacylase active site [active]
405416005067	Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264
405416005068	IucA / IucC family; Region: IucA_IucC; pfam04183
405416005069	Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276
405416005070	Lysine/ornithine N-monooxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: IucD; COG3486
405416005071	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
405416005072	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
405416005073	Major Facilitator Superfamily; Region: MFS_1; pfam07690
405416005074	putative substrate translocation pore; other site
405416005075	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
405416005076	Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264
405416005077	IucA / IucC family; Region: IucA_IucC; pfam04183
405416005078	Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276
405416005079	Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264
405416005080	IucA / IucC family; Region: IucA_IucC; pfam04183
405416005081	Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276
405416005082	FhuF 2Fe-2S C-terminal domain; Region: FhuF_C; pfam11575
405416005083	Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480
405416005084	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
405416005085	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
405416005086	N-terminal plug; other site
405416005087	ligand-binding site [chemical binding]; other site
405416005088	Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182
405416005089	PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703
405416005090	Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523
405416005091	Siderophore biosynthesis protein domain; Region: AlcB; smart01006
405416005092	beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009
405416005093	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
405416005094	motif II; other site
405416005095	Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125
405416005096	2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563
405416005097	Cellular and retroviral pepsin-like aspartate proteases; Region: pepsin_retropepsin_like; cl11403
405416005098	Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544
405416005099	homotrimer interface [polypeptide binding]; other site
405416005100	Walker A motif; other site
405416005101	GTP binding site [chemical binding]; other site
405416005102	Walker B motif; other site
405416005103	Phosphoribosyltransferase; Region: DBI_PRT; pfam02277
405416005104	Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439
405416005105	putative dimer interface [polypeptide binding]; other site
405416005106	active site pocket [active]
405416005107	putative cataytic base [active]
405416005108	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
405416005109	catalytic core [active]
405416005110	Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061
405416005111	cobalamin synthase; Reviewed; Region: cobS; PRK00235
405416005112	phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261
405416005113	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
405416005114	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
405416005115	Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182
405416005116	PepSY-associated TM helix; Region: PepSY_TM_3; pfam13706
405416005117	PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703
405416005118	Outer membrane receptor for ferric coprogen and ferric-rhodotorulic acid [Inorganic ion transport and metabolism]; Region: FhuE; COG4773
405416005119	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
405416005120	N-terminal plug; other site
405416005121	ligand-binding site [chemical binding]; other site
405416005122	lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025
405416005123	ipid-A-disaccharide synthase; Provisional; Region: PRK14089
405416005124	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
405416005125	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
405416005126	Domain of unknown function (DUF1956); Region: DUF1956; pfam09209
405416005127	putative efflux pump membrane fusion protein; Provisional; Region: PRK03598
405416005128	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
405416005129	HlyD family secretion protein; Region: HlyD_3; pfam13437
405416005130	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
405416005131	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
405416005132	Walker A/P-loop; other site
405416005133	ATP binding site [chemical binding]; other site
405416005134	Q-loop/lid; other site
405416005135	ABC transporter signature motif; other site
405416005136	Walker B; other site
405416005137	D-loop; other site
405416005138	H-loop/switch region; other site
405416005139	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
405416005140	ATP-binding cassette domain of the lipid transporters, subfamily A; Region: ABC_subfamily_A; cd03263
405416005141	Walker A/P-loop; other site
405416005142	ATP binding site [chemical binding]; other site
405416005143	Q-loop/lid; other site
405416005144	ABC transporter signature motif; other site
405416005145	Walker B; other site
405416005146	D-loop; other site
405416005147	H-loop/switch region; other site
405416005148	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
405416005149	ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679
405416005150	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
405416005151	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
405416005152	Protein of unknown function (DUF2797); Region: DUF2797; pfam10977
405416005153	Bacterial protein of unknown function (DUF937); Region: DUF937; cl01528
405416005154	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
405416005155	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
405416005156	eyelet of channel; other site
405416005157	trimer interface [polypeptide binding]; other site
405416005158	HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277
405416005159	HIT family signature motif; other site
405416005160	catalytic residue [active]
405416005161	Uncharacterized conserved protein [Function unknown]; Region: COG3791
405416005162	TonB C terminal; Region: TonB_2; pfam13103
405416005163	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
405416005164	S-adenosylmethionine binding site [chemical binding]; other site
405416005165	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
405416005166	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
405416005167	O-succinylhomoserine sulfhydrylase; Validated; Region: PRK08133
405416005168	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
405416005169	homodimer interface [polypeptide binding]; other site
405416005170	substrate-cofactor binding pocket; other site
405416005171	pyridoxal 5'-phosphate binding site [chemical binding]; other site
405416005172	catalytic residue [active]
405416005173	hypothetical protein; Validated; Region: PRK00153
405416005174	recombination protein RecR; Reviewed; Region: recR; PRK00076
405416005175	RecR protein; Region: RecR; pfam02132
405416005176	TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR.  RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025
405416005177	putative active site [active]
405416005178	putative metal-binding site [ion binding]; other site
405416005179	tetramer interface [polypeptide binding]; other site
405416005180	Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349
405416005181	DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142
405416005182	catalytic site [active]
405416005183	putative active site [active]
405416005184	putative substrate binding site [chemical binding]; other site
405416005185	HRDC domain; Region: HRDC; pfam00570
405416005186	YcgL domain; Region: YcgL; pfam05166
405416005187	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
405416005188	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
405416005189	Walker A motif; other site
405416005190	ATP binding site [chemical binding]; other site
405416005191	Walker B motif; other site
405416005192	arginine finger; other site
405416005193	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3825
405416005194	tryptophan synthase, beta subunit; Region: trpB; TIGR00263
405416005195	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
405416005196	pyridoxal 5'-phosphate binding site [chemical binding]; other site
405416005197	catalytic residue [active]
405416005198	HemK family putative methylases; Region: hemK_fam; TIGR00536
405416005199	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
405416005200	S-adenosylmethionine binding site [chemical binding]; other site
405416005201	Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082
405416005202	Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304
405416005203	Tetramer interface [polypeptide binding]; other site
405416005204	active site
405416005205	FMN-binding site [chemical binding]; other site
405416005206	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
405416005207	metal binding site [ion binding]; metal-binding site
405416005208	active site
405416005209	I-site; other site
405416005210	TENA/THI-4/PQQC family; Region: TENA_THI-4; cl15243
405416005211	Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862
405416005212	lipoyl synthase; Provisional; Region: PRK12928
405416005213	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
405416005214	FeS/SAM binding site; other site
405416005215	pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182
405416005216	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
405416005217	tetramer interface [polypeptide binding]; other site
405416005218	TPP-binding site [chemical binding]; other site
405416005219	heterodimer interface [polypeptide binding]; other site
405416005220	phosphorylation loop region [posttranslational modification]
405416005221	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022
405416005222	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
405416005223	alpha subunit interface [polypeptide binding]; other site
405416005224	TPP binding site [chemical binding]; other site
405416005225	heterodimer interface [polypeptide binding]; other site
405416005226	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
405416005227	pyruvate dehydrogenase complex dihydrolipoamide acetyltransferase, long form; Region: PDHac_trf_mito; TIGR01349
405416005228	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
405416005229	E3 interaction surface; other site
405416005230	lipoyl attachment site [posttranslational modification]; other site
405416005231	e3 binding domain; Region: E3_binding; pfam02817
405416005232	e3 binding domain; Region: E3_binding; pfam02817
405416005233	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
405416005234	dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416
405416005235	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
405416005236	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
405416005237	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
405416005238	meso-2,3-butanediol dehydrogenase-like, classical (c) SDRs; Region: meso-BDH-like_SDR_c; cd05366
405416005239	acetoin reductases; Region: 23BDH; TIGR02415
405416005240	NAD binding site [chemical binding]; other site
405416005241	homotetramer interface [polypeptide binding]; other site
405416005242	homodimer interface [polypeptide binding]; other site
405416005243	active site
405416005244	substrate binding site [chemical binding]; other site
405416005245	(2R,3R)-2,3-butanediol dehydrogenase; Region: butanediol_DH_like; cd08233
405416005246	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
405416005247	putative NAD(P) binding site [chemical binding]; other site
405416005248	catalytic Zn binding site [ion binding]; other site
405416005249	Bestrophin, RFP-TM, chloride channel; Region: Bestrophin; pfam01062
405416005250	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
405416005251	psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974
405416005252	Walker A motif; other site
405416005253	ATP binding site [chemical binding]; other site
405416005254	Walker B motif; other site
405416005255	arginine finger; other site
405416005256	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
405416005257	Putative phosphatase (DUF442); Region: DUF442; cl17385
405416005258	Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446
405416005259	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
405416005260	Homoserine dehydrogenase [Amino acid transport and metabolism]; Region: ThrA; COG0460
405416005261	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
405416005262	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
405416005263	EamA-like transporter family; Region: EamA; pfam00892
405416005264	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
405416005265	EamA-like transporter family; Region: EamA; pfam00892
405416005266	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
405416005267	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
405416005268	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
405416005269	Predicted transcriptional regulators [Transcription]; Region: COG1733
405416005270	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
405416005271	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
405416005272	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
405416005273	Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059
405416005274	chromate transporter, chromate ion transporter (CHR) family; Region: 2A51; TIGR00937
405416005275	Chromate transporter; Region: Chromate_transp; pfam02417
405416005276	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
405416005277	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
405416005278	DNA-binding site [nucleotide binding]; DNA binding site
405416005279	UTRA domain; Region: UTRA; pfam07702
405416005280	putative oxidoreductase; Provisional; Region: PRK08275
405416005281	L-aspartate oxidase; Provisional; Region: PRK06175
405416005282	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
405416005283	Ferredoxin [Energy production and conversion]; Region: COG1146
405416005284	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432
405416005285	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
405416005286	substrate binding pocket [chemical binding]; other site
405416005287	membrane-bound complex binding site; other site
405416005288	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
405416005289	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
405416005290	dimer interface [polypeptide binding]; other site
405416005291	conserved gate region; other site
405416005292	putative PBP binding loops; other site
405416005293	ABC-ATPase subunit interface; other site
405416005294	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
405416005295	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
405416005296	Walker A/P-loop; other site
405416005297	ATP binding site [chemical binding]; other site
405416005298	Q-loop/lid; other site
405416005299	ABC transporter signature motif; other site
405416005300	Walker B; other site
405416005301	D-loop; other site
405416005302	H-loop/switch region; other site
405416005303	HEAT repeats; Region: HEAT_2; pfam13646
405416005304	HEAT repeats; Region: HEAT_2; pfam13646
405416005305	HEAT repeats; Region: HEAT_2; pfam13646
405416005306	Protein of unknown function (DUF971); Region: DUF971; pfam06155
405416005307	alpha-ketoglutarate transporter; Provisional; Region: PRK10406
405416005308	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
405416005309	putative substrate translocation pore; other site
405416005310	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
405416005311	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
405416005312	N-terminal plug; other site
405416005313	ligand-binding site [chemical binding]; other site
405416005314	aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273
405416005315	Aspartase; Region: Aspartase; cd01357
405416005316	active sites [active]
405416005317	tetramer interface [polypeptide binding]; other site
405416005318	cell density-dependent motility repressor; Provisional; Region: PRK10082
405416005319	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
405416005320	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
405416005321	dimerization interface [polypeptide binding]; other site
405416005322	Transcriptional regulator [Transcription]; Region: LysR; COG0583
405416005323	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
405416005324	The C-terminal substrate binding domain of LysR-type transcriptional regulators that are involved in the catabolism of dinitrotoluene, naphthalene and gamma-hexachlorohexane; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_NahR_LinR_like; cd08459
405416005325	substrate binding pocket [chemical binding]; other site
405416005326	dimerization interface [polypeptide binding]; other site
405416005327	acetyl-CoA acetyltransferase; Provisional; Region: PRK06954
405416005328	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
405416005329	dimer interface [polypeptide binding]; other site
405416005330	active site
405416005331	Short chain fatty acids transporter [Lipid metabolism]; Region: AtoE; COG2031
405416005332	3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428
405416005333	Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788
405416005334	Transcriptional regulator [Transcription]; Region: LysR; COG0583
405416005335	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
405416005336	TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440
405416005337	putative dimerization interface [polypeptide binding]; other site
405416005338	H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610
405416005339	fructuronate transporter; Provisional; Region: PRK10034; cl15264
405416005340	3-hydroxybutyrate dehydrogenase; Provisional; Region: PRK12429
405416005341	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
405416005342	NAD(P) binding site [chemical binding]; other site
405416005343	active site
405416005344	Helix-turn-helix domain; Region: HTH_18; pfam12833
405416005345	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
405416005346	benzoate transport; Region: 2A0115; TIGR00895
405416005347	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
405416005348	putative substrate translocation pore; other site
405416005349	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
405416005350	Dienelactone hydrolase family; Region: DLH; pfam01738
405416005351	SnoaL-like domain; Region: SnoaL_2; pfam12680
405416005352	short chain dehydrogenase; Provisional; Region: PRK08265
405416005353	classical (c) SDRs; Region: SDR_c; cd05233
405416005354	NAD(P) binding site [chemical binding]; other site
405416005355	active site
405416005356	Flavin reductase like domain; Region: Flavin_Reduct; smart00903
405416005357	Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; cl01768
405416005358	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
405416005359	Helix-turn-helix domain; Region: HTH_18; pfam12833
405416005360	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
405416005361	anthranilate dioxygenase reductase; Provisional; Region: antC; PRK11872
405416005362	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
405416005363	catalytic loop [active]
405416005364	iron binding site [ion binding]; other site
405416005365	Benzoate dioxygenase reductase (BenDO) FAD/NAD binding domain. Oxygenases oxidize hydrocarbons using dioxygen as the oxidant. As a Class I bacterial dioxygenases, benzoate dioxygenase like proteins combine an [2Fe-2S] cluster containing N-terminal...; Region: BenDO_FAD_NAD; cd06209
405416005366	FAD binding pocket [chemical binding]; other site
405416005367	FAD binding motif [chemical binding]; other site
405416005368	phosphate binding motif [ion binding]; other site
405416005369	beta-alpha-beta structure motif; other site
405416005370	NAD binding pocket [chemical binding]; other site
405416005371	Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667
405416005372	inter-subunit interface; other site
405416005373	anthranilate 1,2-dioxygenase, large subunit; Region: anthran_1_2_A; TIGR03228
405416005374	Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469
405416005375	[2Fe-2S] cluster binding site [ion binding]; other site
405416005376	C-terminal catalytic domain of the oxygenase alpha subunit of Pseudomonas resinovorans strain CA10 anthranilate 1,2-dioxygenase and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_AntDO-like; cd08879
405416005377	putative alpha subunit interface [polypeptide binding]; other site
405416005378	putative active site [active]
405416005379	putative substrate binding site [chemical binding]; other site
405416005380	Fe binding site [ion binding]; other site
405416005381	N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; cl17549
405416005382	molybdate transporter periplasmic protein; Provisional; Region: modA; PRK10677
405416005383	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
405416005384	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
405416005385	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
405416005386	dimer interface [polypeptide binding]; other site
405416005387	conserved gate region; other site
405416005388	putative PBP binding loops; other site
405416005389	ABC-ATPase subunit interface; other site
405416005390	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
405416005391	phosphonate C-P lyase system protein PhnL; Region: CP_lyasePhnL; TIGR02324
405416005392	Walker A/P-loop; other site
405416005393	ATP binding site [chemical binding]; other site
405416005394	Q-loop/lid; other site
405416005395	ABC transporter signature motif; other site
405416005396	Walker B; other site
405416005397	D-loop; other site
405416005398	H-loop/switch region; other site
405416005399	2,3-dihydroxybenzoate-2,3-dehydrogenase; Validated; Region: PRK08220
405416005400	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
405416005401	NAD(P) binding site [chemical binding]; other site
405416005402	active site
405416005403	Isochorismatase, also known as 2,3 dihydro-2,3 dihydroxybenzoate synthase, catalyses the conversion of isochorismate, in the presence of water, to 2,3-dihydroxybenzoate and pyruvate, via the hydrolysis of a vinyl ether, an uncommon reaction in biological...; Region: isochorismatase; cd01013
405416005404	hydrophobic substrate binding pocket; other site
405416005405	Isochorismatase family; Region: Isochorismatase; pfam00857
405416005406	active site
405416005407	conserved cis-peptide bond; other site
405416005408	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cl17326
405416005409	metal binding site 2 [ion binding]; metal-binding site
405416005410	putative DNA binding helix; other site
405416005411	metal binding site 1 [ion binding]; metal-binding site
405416005412	dimer interface [polypeptide binding]; other site
405416005413	structural Zn2+ binding site [ion binding]; other site
405416005414	5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737
405416005415	Bacillus subtilis YhcR endonuclease and related proteins, N-terminal metallophosphatase domain; Region: MPP_YhcR_N; cd07412
405416005416	putative active site [active]
405416005417	putative metal binding site [ion binding]; other site
405416005418	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
405416005419	polyphosphate kinase; Provisional; Region: PRK05443
405416005420	Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089
405416005421	Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503
405416005422	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
405416005423	putative active site [active]
405416005424	catalytic site [active]
405416005425	Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168
405416005426	putative domain interface [polypeptide binding]; other site
405416005427	putative active site [active]
405416005428	catalytic site [active]
405416005429	pyrroloquinoline quinone biosynthesis protein PqqB; Provisional; Region: PRK05184
405416005430	coenzyme PQQ biosynthesis protein B; Region: PQQ_syn_pqqB; TIGR02108
405416005431	pyrroloquinoline quinone biosynthesis protein PqqC; Provisional; Region: PRK05157
405416005432	pyrroloquinoline quinone biosynthesis protein PqqD; Provisional; Region: PRK02079
405416005433	pyrroloquinoline quinone biosynthesis protein PqqE; Provisional; Region: PRK05301
405416005434	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
405416005435	FeS/SAM binding site; other site
405416005436	radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085
405416005437	Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355
405416005438	renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301
405416005439	active site
405416005440	dimer interface [polypeptide binding]; other site
405416005441	MUG-like Uracil-DNA glycosylase enzyme family; Region: UDG_MUG_like; cd10032
405416005442	putative active site [active]
405416005443	Putative catalytic domain, repeat 1, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_1; cd09111
405416005444	PLD-like domain; Region: PLDc_2; pfam13091
405416005445	putative active site [active]
405416005446	catalytic site [active]
405416005447	Putative catalytic domain, repeat 2, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_2; cd09113
405416005448	PLD-like domain; Region: PLDc_2; pfam13091
405416005449	putative active site [active]
405416005450	catalytic site [active]
405416005451	Catalase-like heme-binding proteins similar to the uncharacterized y4iL; Region: y4iL_like; cd08152
405416005452	putative heme binding pocket [chemical binding]; other site
405416005453	class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300
405416005454	S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase; Region: adh_III_F_hyde; TIGR02818
405416005455	substrate binding site [chemical binding]; other site
405416005456	catalytic Zn binding site [ion binding]; other site
405416005457	NAD binding site [chemical binding]; other site
405416005458	structural Zn binding site [ion binding]; other site
405416005459	dimer interface [polypeptide binding]; other site
405416005460	P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539
405416005461	P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188
405416005462	PapC N-terminal domain; Region: PapC_N; pfam13954
405416005463	Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577
405416005464	PapC C-terminal domain; Region: PapC_C; pfam13953
405416005465	P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121
405416005466	Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345
405416005467	Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753
405416005468	P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539
405416005469	Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; cl17479
405416005470	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
405416005471	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
405416005472	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
405416005473	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
405416005474	Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748
405416005475	Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593
405416005476	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
405416005477	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
405416005478	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
405416005479	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
405416005480	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
405416005481	alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561
405416005482	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
405416005483	The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915
405416005484	Protein export membrane protein; Region: SecD_SecF; cl14618
405416005485	Protein export membrane protein; Region: SecD_SecF; cl14618
405416005486	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
405416005487	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
405416005488	HlyD family secretion protein; Region: HlyD_3; pfam13437
405416005489	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
405416005490	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
405416005491	active site
405416005492	phosphorylation site [posttranslational modification]
405416005493	intermolecular recognition site; other site
405416005494	dimerization interface [polypeptide binding]; other site
405416005495	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
405416005496	DNA binding site [nucleotide binding]
405416005497	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
405416005498	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
405416005499	dimerization interface [polypeptide binding]; other site
405416005500	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
405416005501	dimer interface [polypeptide binding]; other site
405416005502	phosphorylation site [posttranslational modification]
405416005503	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
405416005504	ATP binding site [chemical binding]; other site
405416005505	Mg2+ binding site [ion binding]; other site
405416005506	G-X-G motif; other site
405416005507	Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625
405416005508	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220
405416005509	dimerization interface [polypeptide binding]; other site
405416005510	putative DNA binding site [nucleotide binding]; other site
405416005511	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
405416005512	putative Zn2+ binding site [ion binding]; other site
405416005513	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
405416005514	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
405416005515	Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028
405416005516	classical (c) SDRs; Region: SDR_c; cd05233
405416005517	NAD(P) binding site [chemical binding]; other site
405416005518	active site
405416005519	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
405416005520	classical (c) SDRs; Region: SDR_c; cd05233
405416005521	NAD(P) binding site [chemical binding]; other site
405416005522	active site
405416005523	PAAR motif; Region: PAAR_motif; pfam05488
405416005524	Phage antirepressor protein KilAC domain; Region: ANT; pfam03374
405416005525	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
405416005526	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
405416005527	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
405416005528	non-specific DNA binding site [nucleotide binding]; other site
405416005529	salt bridge; other site
405416005530	sequence-specific DNA binding site [nucleotide binding]; other site
405416005531	HD domain; Region: HD_4; pfam13328
405416005532	Survival protein SurE; Region: SurE; pfam01975
405416005533	type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844
405416005534	GH3 auxin-responsive promoter; Region: GH3; pfam03321
405416005535	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
405416005536	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
405416005537	putative substrate translocation pore; other site
405416005538	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
405416005539	Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566
405416005540	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
405416005541	HlyD family secretion protein; Region: HlyD_3; pfam13437
405416005542	indole acetimide hydrolase; Validated; Region: PRK07488
405416005543	Amidase; Region: Amidase; pfam01425
405416005544	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
405416005545	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
405416005546	DNA binding residues [nucleotide binding]
405416005547	dimerization interface [polypeptide binding]; other site
405416005548	Methylene-tetrahydrofolate reductase C terminal; Region: MTHFR_C; pfam12225
405416005549	Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cl00246
405416005550	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883
405416005551	nudix motif; other site
405416005552	Uncharacterized conserved protein [General function prediction only]; Region: COG4111
405416005553	putative nicotinate phosphoribosyltransferase; Provisional; Region: PRK09198
405416005554	pre-B-cell colony-enhancing factor (PBEF)-like. The mammalian members of this group of nicotinate phosphoribosyltransferases (NAPRTases) were originally identified as genes whose expression is upregulated upon activation in lymphoid cells. In general; Region: PBEF_like; cd01569
405416005555	active site
405416005556	Phosphoribosylpyrophosphate synthetase [Nucleotide transport and metabolism / Amino acid transport and metabolism]; Region: PrsA; COG0462
405416005557	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
405416005558	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
405416005559	active site
405416005560	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
405416005561	Cupin domain; Region: Cupin_2; cl17218
405416005562	Helix-turn-helix domain; Region: HTH_18; pfam12833
405416005563	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
405416005564	Coenzyme A binding pocket [chemical binding]; other site
405416005565	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
405416005566	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
405416005567	Walker A/P-loop; other site
405416005568	ATP binding site [chemical binding]; other site
405416005569	Q-loop/lid; other site
405416005570	ABC transporter signature motif; other site
405416005571	Walker B; other site
405416005572	D-loop; other site
405416005573	H-loop/switch region; other site
405416005574	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
405416005575	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
405416005576	ABC-ATPase subunit  interface; other site
405416005577	dimer interface [polypeptide binding]; other site
405416005578	putative PBP binding regions; other site
405416005579	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
405416005580	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
405416005581	intersubunit interface [polypeptide binding]; other site
405416005582	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
405416005583	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283
405416005584	putative NAD(P) binding site [chemical binding]; other site
405416005585	putative substrate binding site [chemical binding]; other site
405416005586	catalytic Zn binding site [ion binding]; other site
405416005587	structural Zn binding site [ion binding]; other site
405416005588	dimer interface [polypeptide binding]; other site
405416005589	Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599
405416005590	Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599
405416005591	Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917
405416005592	AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719
405416005593	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
405416005594	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
405416005595	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
405416005596	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
405416005597	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
405416005598	4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332
405416005599	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
405416005600	putative substrate translocation pore; other site
405416005601	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
405416005602	Escherichia coli Gne (a nucleoside-diphosphate-sugar 4-epimerase)-like, extended (e) SDRs; Region: Gne_like_SDR_e; cd05238
405416005603	putative NAD(P) binding site [chemical binding]; other site
405416005604	active site
405416005605	putative substrate binding site [chemical binding]; other site
405416005606	Transcriptional regulator [Transcription]; Region: LysR; COG0583
405416005607	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
405416005608	The C-terminal substrate binding domain of galactose-binding protein regulator contains the type 2 periplasmic binding fold; Region: PBP2_GbpR; cd08435
405416005609	putative dimerization interface [polypeptide binding]; other site
405416005610	Fumarylacetoacetate (FAA) hydrolase family protein [General function prediction only]; Region: COG3970
405416005611	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
405416005612	dihydroxy-acid dehydratase; Provisional; Region: PRK13017
405416005613	NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012
405416005614	Alpha-Ketoglutaric Semialdehyde Dehydrogenase; Region: ALDH_KGSADH; cd07129
405416005615	dimer interface [polypeptide binding]; other site
405416005616	NADP binding site [chemical binding]; other site
405416005617	catalytic residues [active]
405416005618	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
405416005619	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
405416005620	AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246
405416005621	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
405416005622	putative substrate translocation pore; other site
405416005623	Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566
405416005624	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
405416005625	HlyD family secretion protein; Region: HlyD_3; pfam13437
405416005626	RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931
405416005627	type I secretion C-terminal target domain (VC_A0849 subclass); Region: T1SS_VCA0849; TIGR03661
405416005628	Antitoxin of toxin-antitoxin stability system N-terminal; Region: RelB_N; pfam12910
405416005629	hypothetical protein; Validated; Region: PRK06201
405416005630	Demethylmenaquinone methyltransferase [Coenzyme metabolism]; Region: MenG; COG0684
405416005631	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
405416005632	Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173
405416005633	ligand binding site [chemical binding]; other site
405416005634	NAD binding site [chemical binding]; other site
405416005635	dimerization interface [polypeptide binding]; other site
405416005636	catalytic site [active]
405416005637	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
405416005638	Major Facilitator Superfamily; Region: MFS_1; pfam07690
405416005639	putative substrate translocation pore; other site
405416005640	IclR helix-turn-helix domain; Region: HTH_IclR; cl17605
405416005641	Transcriptional regulator [Transcription]; Region: IclR; COG1414
405416005642	Bacterial transcriptional regulator; Region: IclR; pfam01614
405416005643	Protein of unknown function, DUF606; Region: DUF606; pfam04657
405416005644	Protein of unknown function, DUF606; Region: DUF606; pfam04657
405416005645	Transcriptional regulator [Transcription]; Region: LysR; COG0583
405416005646	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
405416005647	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
405416005648	putative effector binding pocket; other site
405416005649	dimerization interface [polypeptide binding]; other site
405416005650	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
405416005651	putative substrate translocation pore; other site
405416005652	Major Facilitator Superfamily; Region: MFS_1; pfam07690
405416005653	SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450
405416005654	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567
405416005655	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
405416005656	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
405416005657	DNA-binding site [nucleotide binding]; DNA binding site
405416005658	The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866
405416005659	Dicarboxylate carrier protein MatC N-terminus; Region: MatC_N; pfam07158
405416005660	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
405416005661	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221
405416005662	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
405416005663	Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618
405416005664	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
405416005665	active site
405416005666	4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332
405416005667	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
405416005668	putative substrate translocation pore; other site
405416005669	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
405416005670	haemagglutination activity domain; Region: Haemagg_act; pfam05860
405416005671	Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; cl01733
405416005672	Possible hemagglutinin (DUF637); Region: DUF637; pfam04830
405416005673	Pre-toxin domain with VENN motif; Region: PT-VENN; pfam04829
405416005674	MafB19-like deaminase; Region: MafB19-deam; pfam14437
405416005675	Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831
405416005676	POTRA domain, ShlB-type; Region: POTRA_2; pfam08479
405416005677	Haemolysin secretion/activation protein ShlB/FhaC/HecB; Region: ShlB; pfam03865
405416005678	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
405416005679	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
405416005680	M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like2; cd05667
405416005681	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
405416005682	metal binding site [ion binding]; metal-binding site
405416005683	putative dimer interface [polypeptide binding]; other site
405416005684	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
405416005685	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
405416005686	Kef-type K+ transport systems, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: Kch; COG1226
405416005687	TrkA-N domain; Region: TrkA_N; pfam02254
405416005688	dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606
405416005689	Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995
405416005690	LysR family transcriptional regulator; Provisional; Region: PRK14997
405416005691	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
405416005692	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_4; cd08473
405416005693	putative effector binding pocket; other site
405416005694	putative dimerization interface [polypeptide binding]; other site
405416005695	Isochorismatase family; Region: Isochorismatase; pfam00857
405416005696	YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012
405416005697	catalytic triad [active]
405416005698	dimer interface [polypeptide binding]; other site
405416005699	conserved cis-peptide bond; other site
405416005700	Uncharacterized conserved protein [Function unknown]; Region: COG1359
405416005701	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
405416005702	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
405416005703	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
405416005704	Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706
405416005705	Transcriptional regulator; Region: Rrf2; pfam02082
405416005706	Rrf2 family protein; Region: rrf2_super; TIGR00738
405416005707	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
405416005708	Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693
405416005709	Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141
405416005710	potential catalytic triad [active]
405416005711	conserved cys residue [active]
405416005712	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
405416005713	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
405416005714	DNA binding residues [nucleotide binding]
405416005715	RibD C-terminal domain; Region: RibD_C; cl17279
405416005716	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
405416005717	Uncharacterized conserved protein [Function unknown]; Region: COG3268
405416005718	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
405416005719	NAD(P) binding site [chemical binding]; other site
405416005720	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
405416005721	Old yellow enzyme (OYE)-related FMN binding domain, group 2.  Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_2_FMN; cd04733
405416005722	putative active site [active]
405416005723	putative FMN binding site [chemical binding]; other site
405416005724	putative substrate binding site [chemical binding]; other site
405416005725	putative catalytic residue [active]
405416005726	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
405416005727	MarR family; Region: MarR; pfam01047
405416005728	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
405416005729	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
405416005730	Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141
405416005731	Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693
405416005732	potential catalytic triad [active]
405416005733	conserved cys residue [active]
405416005734	2-oxoglutarate dehydrogenase E2 component; Region: PLN02226
405416005735	Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753
405416005736	Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156
405416005737	tetramer interface [polypeptide binding]; other site
405416005738	heme binding pocket [chemical binding]; other site
405416005739	NADPH binding site [chemical binding]; other site
405416005740	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
405416005741	alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561
405416005742	Acetoacetate decarboxylase (ADC); Region: ADC; cl01919
405416005743	aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381
405416005744	Coniferyl aldehyde dehydrogenase-like; Region: ALDH_CALDH_CalB; cd07133
405416005745	NAD(P) binding site [chemical binding]; other site
405416005746	catalytic residues [active]
405416005747	putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824
405416005748	PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276
405416005749	NAD(P) binding site [chemical binding]; other site
405416005750	Predicted symporter [General function prediction only]; Region: DhlC; COG4147
405416005751	Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480
405416005752	Na binding site [ion binding]; other site
405416005753	Protein of unknown function, DUF485; Region: DUF485; pfam04341
405416005754	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07008
405416005755	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
405416005756	acyl-activating enzyme (AAE) consensus motif; other site
405416005757	AMP binding site [chemical binding]; other site
405416005758	active site
405416005759	CoA binding site [chemical binding]; other site
405416005760	Propionate catabolism activator; Region: PrpR_N; pfam06506
405416005761	psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974
405416005762	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
405416005763	Walker A motif; other site
405416005764	ATP binding site [chemical binding]; other site
405416005765	Walker B motif; other site
405416005766	arginine finger; other site
405416005767	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
405416005768	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
405416005769	classical (c) SDRs; Region: SDR_c; cd05233
405416005770	NAD(P) binding site [chemical binding]; other site
405416005771	active site
405416005772	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
405416005773	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
405416005774	active site
405416005775	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
405416005776	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
405416005777	active site
405416005778	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
405416005779	catalytic core [active]
405416005780	Phosphotransferase enzyme family; Region: APH; pfam01636
405416005781	Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154
405416005782	putative active site [active]
405416005783	putative substrate binding site [chemical binding]; other site
405416005784	ATP binding site [chemical binding]; other site
405416005785	NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012
405416005786	Alpha-Ketoglutaric Semialdehyde Dehydrogenase; Region: ALDH_KGSADH; cd07129
405416005787	dimer interface [polypeptide binding]; other site
405416005788	NADP binding site [chemical binding]; other site
405416005789	catalytic residues [active]
405416005790	Uncharacterized protein conserved in bacteria [Function unknown]; Region: GguC; COG3802
405416005791	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
405416005792	4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332
405416005793	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
405416005794	putative substrate translocation pore; other site
405416005795	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
405416005796	dihydroxy-acid dehydratase; Validated; Region: PRK06131
405416005797	Transcriptional regulators [Transcription]; Region: FadR; COG2186
405416005798	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
405416005799	DNA-binding site [nucleotide binding]; DNA binding site
405416005800	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
405416005801	Bacterial protein of unknown function (Gcw_chp); Region: Gcw_chp; pfam09694
405416005802	DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906
405416005803	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
405416005804	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
405416005805	dimerization interface [polypeptide binding]; other site
405416005806	muconate and chloromuconate cycloisomerases; Region: mucon_cyclo; TIGR02534
405416005807	Muconate Lactonizing Enzyme (MLE), an homooctameric enzyme, catalyses the conversion of cis,cis-muconate (CCM) to muconolactone (ML) in the catechol branch of the beta-ketoadipate pathway. This pathway is used in soil microbes to breakdown lignin-derived...; Region: MLE; cd03318
405416005808	octamer interface [polypeptide binding]; other site
405416005809	active site
405416005810	muconolactone delta-isomerase; Region: muco_delta; TIGR03221
405416005811	catechol 1,2-dioxygenase, proteobacterial; Region: catechol_proteo; TIGR02439
405416005812	Catechol 1,2 dioxygenase (1,2-CTD) catalyzes an intradiol cleavage reaction of catechol to form cis,cis-muconate. 1,2-CTDs is homodimers with one catalytic non-heme ferric ion per monomer. They belong to the aromatic dioxygenase family, a family of...; Region: 1,2-CTD; cd03460
405416005813	dimer interface [polypeptide binding]; other site
405416005814	active site
405416005815	3-oxoacid CoA-transferase, A subunit; Region: pcaI_scoA_fam; TIGR02429
405416005816	3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428
405416005817	beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050
405416005818	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
405416005819	dimer interface [polypeptide binding]; other site
405416005820	active site
405416005821	3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427
405416005822	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
405416005823	Protein related to penicillin acylase [General function prediction only]; Region: COG2366
405416005824	The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid.  N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467
405416005825	The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid.  N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467
405416005826	active site
405416005827	Escherichia coli NAD+-dependent phenylacetaldehyde dehydrogenase PadA-like; Region: ALDH_PADH_NahF; cd07113
405416005828	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
405416005829	NAD(P) binding site [chemical binding]; other site
405416005830	catalytic residues [active]
405416005831	tyramine oxidase; Provisional; Region: tynA; PRK14696
405416005832	Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833
405416005833	Copper amine oxidase, N3 domain; Region: Cu_amine_oxidN3; pfam02728
405416005834	Copper amine oxidase, enzyme domain; Region: Cu_amine_oxid; pfam01179
405416005835	DNA-binding transcriptional activator FeaR; Provisional; Region: PRK09685
405416005836	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
405416005837	Flavin reductase like domain; Region: Flavin_Reduct; smart00903
405416005838	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
405416005839	Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal  ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185
405416005840	FMN-binding pocket [chemical binding]; other site
405416005841	flavin binding motif; other site
405416005842	phosphate binding motif [ion binding]; other site
405416005843	beta-alpha-beta structure motif; other site
405416005844	NAD binding pocket [chemical binding]; other site
405416005845	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
405416005846	catalytic loop [active]
405416005847	iron binding site [ion binding]; other site
405416005848	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
405416005849	classical (c) SDRs; Region: SDR_c; cd05233
405416005850	NAD(P) binding site [chemical binding]; other site
405416005851	active site
405416005852	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
405416005853	benzoate 1,2-dioxygenase, large subunit; Region: benzo_1_2_benA; TIGR03229
405416005854	Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469
405416005855	[2Fe-2S] cluster binding site [ion binding]; other site
405416005856	C-terminal catalytic domain of the oxygenase alpha subunit of Pseudomonas resinovorans strain CA10 anthranilate 1,2-dioxygenase and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_AntDO-like; cd08879
405416005857	putative alpha subunit interface [polypeptide binding]; other site
405416005858	putative active site [active]
405416005859	putative substrate binding site [chemical binding]; other site
405416005860	Fe binding site [ion binding]; other site
405416005861	SnoaL-like domain; Region: SnoaL_4; pfam13577
405416005862	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
405416005863	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
405416005864	active site
405416005865	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
405416005866	Amidase; Region: Amidase; cl11426
405416005867	Transcriptional regulators [Transcription]; Region: MarR; COG1846
405416005868	Winged helix DNA-binding domain; Region: HTH_27; pfam13463
405416005869	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
405416005870	Major Facilitator Superfamily; Region: MFS_1; pfam07690
405416005871	putative substrate translocation pore; other site
405416005872	outer membrane porin, OprD family; Region: OprD; pfam03573
405416005873	short chain dehydrogenase; Provisional; Region: PRK08251
405416005874	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
405416005875	NAD(P) binding site [chemical binding]; other site
405416005876	active site
405416005877	Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040
405416005878	catalytic core [active]
405416005879	thiamine kinase; Region: ycfN_thiK; TIGR02721
405416005880	Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154
405416005881	putative active site [active]
405416005882	putative substrate binding site [chemical binding]; other site
405416005883	ATP binding site [chemical binding]; other site
405416005884	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
405416005885	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
405416005886	active site
405416005887	Transcriptional regulator [Transcription]; Region: LysR; COG0583
405416005888	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
405416005889	The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417
405416005890	substrate binding pocket [chemical binding]; other site
405416005891	dimerization interface [polypeptide binding]; other site
405416005892	beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Region: pcaR_pcaU; TIGR02431
405416005893	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
405416005894	Bacterial transcriptional regulator; Region: IclR; pfam01614
405416005895	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
405416005896	Predicted transporter component [General function prediction only]; Region: COG2391
405416005897	Domain of unknown function (DUF4341); Region: DUF4341; pfam14241
405416005898	7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695
405416005899	membrane-bound PQQ-dependent dehydrogenase, glucose/quinate/shikimate family; Region: PQQ_membr_DH; TIGR03074
405416005900	Membrane-bound PQQ-dependent glucose dehydrogenase; Region: PQQ_mGDH; cd10280
405416005901	Trp docking motif [polypeptide binding]; other site
405416005902	putative active site [active]
405416005903	Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966
405416005904	Right handed beta helix region; Region: Beta_helix; pfam13229
405416005905	Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502
405416005906	3-dehydroquinate dehydratase [Amino acid transport and metabolism]; Region: AroD; COG0710
405416005907	active site
405416005908	catalytic residue [active]
405416005909	dimer interface [polypeptide binding]; other site
405416005910	Protocatechuate 3,4-dioxygenase beta subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PcaH; COG3485
405416005911	Protocatechuate 3,4-dioxygenase (3,4-PCD) , alpha subunit. 3,4-PCD catalyzes the oxidative ring cleavage of 3,4-dihydroxybenzoate to produce beta-carboxy-cis,cis-muconate. 3,4-PCDs are large aggregates of 12 protomers, each composed of an alpha- and...; Region: 3,4-PCD_alpha; cd03463
405416005912	heterodimer interface [polypeptide binding]; other site
405416005913	active site
405416005914	Protocatechuate 3,4-dioxygenase (3,4-PCD) , beta subunit. 3,4-PCD catalyzes the oxidative ring cleavage of 3,4-dihydroxybenzoate to produce beta-carboxy-cis,cis-muconate. 3,4-PCDs are large aggregates of 12 protomers, each composed of an alpha- and...; Region: 3,4-PCD_beta; cd03464
405416005915	heterodimer interface [polypeptide binding]; other site
405416005916	multimer interface [polypeptide binding]; other site
405416005917	protocatechuate 3,4-dioxygenase, beta subunit; Region: protocat_beta; TIGR02422
405416005918	active site
405416005919	Carboxymuconolactone decarboxylase family; Region: CMD; cl00460
405416005920	benzoate transport; Region: 2A0115; TIGR00895
405416005921	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
405416005922	putative substrate translocation pore; other site
405416005923	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
405416005924	3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427
405416005925	3-carboxy-cis,cis-muconate cycloisomerase; Provisional; Region: PRK09053
405416005926	prokaryotic 3-carboxy-cis,cis-muconate cycloisomerase (CMLE)_like; Region: pCLME; cd01597
405416005927	tetramer interface [polypeptide binding]; other site
405416005928	active site
405416005929	beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050
405416005930	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
405416005931	dimer interface [polypeptide binding]; other site
405416005932	active site
405416005933	3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428
405416005934	Coenzyme A transferase; Region: CoA_trans; cl17247
405416005935	Coenzyme A transferase; Region: CoA_trans; cl17247
405416005936	CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516
405416005937	substrate binding site; other site
405416005938	dimer interface; other site
405416005939	Septum formation initiator; Region: DivIC; cl17659
405416005940	Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919
405416005941	Predicted membrane protein [Function unknown]; Region: COG2323
405416005942	enolase; Provisional; Region: eno; PRK00077
405416005943	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
405416005944	dimer interface [polypeptide binding]; other site
405416005945	metal binding site [ion binding]; metal-binding site
405416005946	substrate binding pocket [chemical binding]; other site
405416005947	2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198
405416005948	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
405416005949	CTP synthetase; Validated; Region: pyrG; PRK05380
405416005950	CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113
405416005951	Catalytic site [active]
405416005952	active site
405416005953	UTP binding site [chemical binding]; other site
405416005954	Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746
405416005955	active site
405416005956	putative oxyanion hole; other site
405416005957	catalytic triad [active]
405416005958	Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687
405416005959	Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118
405416005960	Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; Region: COG0429
405416005961	SGNH_hydrolase subfamily, FeeA, FeeB and similar esterases/lipases. FeeA and FeeB are part of a biosynthetic gene cluster and may participate in the biosynthesis of long-chain N-acyltyrosines by providing saturated and unsaturated fatty acids, which it...; Region: FeeA_FeeB_like; cd01836
405416005962	active site
405416005963	catalytic triad [active]
405416005964	oxyanion hole [active]
405416005965	SnoaL-like domain; Region: SnoaL_2; pfam12680
405416005966	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
405416005967	2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli  is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930
405416005968	active site
405416005969	FMN binding site [chemical binding]; other site
405416005970	2,4-decadienoyl-CoA binding site; other site
405416005971	catalytic residue [active]
405416005972	4Fe-4S cluster binding site [ion binding]; other site
405416005973	Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446
405416005974	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
405416005975	Predicted transcriptional regulators [Transcription]; Region: COG1695
405416005976	Transcriptional regulator PadR-like family; Region: PadR; cl17335
405416005977	Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400
405416005978	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
405416005979	phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12755
405416005980	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
405416005981	hypothetical protein; Provisional; Region: PRK02237
405416005982	ATP-dependent Clp protease ATP-binding subunit clpA; Region: ClpA; TIGR02639
405416005983	Clp amino terminal domain; Region: Clp_N; pfam02861
405416005984	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
405416005985	Walker A motif; other site
405416005986	ATP binding site [chemical binding]; other site
405416005987	Walker B motif; other site
405416005988	arginine finger; other site
405416005989	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
405416005990	Walker A motif; other site
405416005991	ATP binding site [chemical binding]; other site
405416005992	Walker B motif; other site
405416005993	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
405416005994	Uncharacterized conserved protein [Function unknown]; Region: COG2127
405416005995	Membrane-anchored protein predicted to be involved in regulation of amylopullulanase [Carbohydrate transport and metabolism]; Region: COG4945
405416005996	N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436
405416005997	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
405416005998	Protein of unknown function DUF45; Region: DUF45; pfam01863
405416005999	RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398
405416006000	tetramer (dimer of dimers) interface [polypeptide binding]; other site
405416006001	active site
405416006002	dimer interface [polypeptide binding]; other site
405416006003	threonine dehydratase; Reviewed; Region: PRK09224
405416006004	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
405416006005	tetramer interface [polypeptide binding]; other site
405416006006	pyridoxal 5'-phosphate binding site [chemical binding]; other site
405416006007	catalytic residue [active]
405416006008	First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906
405416006009	putative Ile/Val binding site [chemical binding]; other site
405416006010	Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907
405416006011	putative Ile/Val binding site [chemical binding]; other site
405416006012	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
405416006013	TrkA-N domain; Region: TrkA_N; pfam02254
405416006014	Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168
405416006015	potassium uptake protein, TrkH family; Region: 2a38; TIGR00933
405416006016	The outer membrane phospholipase A (OMPLA) is an integral membrane enzyme that catalyses the hydrolysis of acylester bonds in phospholipids using calcium as a cofactor. The enzyme has a fold of transmembrane beta-barrels and is widespread among...; Region: OMPLA; cd00541
405416006017	dimerization interface [polypeptide binding]; other site
405416006018	substrate binding site [chemical binding]; other site
405416006019	active site
405416006020	calcium binding site [ion binding]; other site
405416006021	Predicted Zn-dependent peptidases, insulinase-like [General function prediction only]; Region: COG1026
405416006022	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
405416006023	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
405416006024	Peptidase M16C associated; Region: M16C_assoc; pfam08367
405416006025	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
405416006026	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
405416006027	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
405416006028	N-terminal plug; other site
405416006029	ligand-binding site [chemical binding]; other site
405416006030	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
405416006031	Adenosine kinase (AK) catalyzes the phosphorylation of ribofuranosyl-containing nucleoside analogues at the 5'-hydroxyl using ATP or GTP as the phosphate donor.The physiological function of AK is associated with the regulation of extracellular...; Region: adenosine_kinase; cd01168
405416006032	substrate binding site [chemical binding]; other site
405416006033	ATP binding site [chemical binding]; other site
405416006034	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467
405416006035	iron-sulfur cluster [ion binding]; other site
405416006036	[2Fe-2S] cluster binding site [ion binding]; other site
405416006037	Protein of unknown function (DUF1449); Region: DUF1449; pfam07290
405416006038	putative transposase OrfB; Reviewed; Region: PHA02517
405416006039	HTH-like domain; Region: HTH_21; pfam13276
405416006040	Integrase core domain; Region: rve; pfam00665
405416006041	Integrase core domain; Region: rve_3; pfam13683
405416006042	Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562
405416006043	cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219
405416006044	Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322
405416006045	Cyd operon protein YbgE (Cyd_oper_YbgE); Region: Cyd_oper_YbgE; pfam09600
405416006046	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
405416006047	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
405416006048	Coenzyme A binding pocket [chemical binding]; other site
405416006049	Uncharacterized protein conserved in bacteria (DUF2057); Region: DUF2057; pfam09829
405416006050	Nitroreductase-like family 4.  A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_4; cd02140
405416006051	dimer interface [polypeptide binding]; other site
405416006052	FMN binding site [chemical binding]; other site
405416006053	signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416
405416006054	SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881
405416006055	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
405416006056	P loop; other site
405416006057	GTP binding site [chemical binding]; other site
405416006058	Protein of unknown function (DUF2750); Region: DUF2750; pfam11042
405416006059	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_10; cd04623
405416006060	FOG: CBS domain [General function prediction only]; Region: COG0517
405416006061	acetylornithine aminotransferase; Provisional; Region: PRK02627
405416006062	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
405416006063	inhibitor-cofactor binding pocket; inhibition site
405416006064	pyridoxal 5'-phosphate binding site [chemical binding]; other site
405416006065	catalytic residue [active]
405416006066	Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028
405416006067	putative GSH binding site [chemical binding]; other site
405416006068	catalytic residues [active]
405416006069	LysR family transcriptional regulator; Provisional; Region: PRK14997
405416006070	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
405416006071	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_4; cd08473
405416006072	putative effector binding pocket; other site
405416006073	putative dimerization interface [polypeptide binding]; other site
405416006074	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
405416006075	active site
405416006076	Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547
405416006077	Uncharacterized protein, possibly involved in utilization of glycolate and propanediol [General function prediction only]; Region: GlcG; COG3193
405416006078	Predicted alpha/beta hydrolase [General function prediction only]; Region: COG4757
405416006079	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
405416006080	bifunctional PTS system fructose-specific transporter subunit IIA/HPr protein; Provisional; Region: PRK11109
405416006081	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
405416006082	active site
405416006083	phosphorylation site [posttranslational modification]
405416006084	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cl00163
405416006085	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
405416006086	dimerization domain swap beta strand [polypeptide binding]; other site
405416006087	regulatory protein interface [polypeptide binding]; other site
405416006088	active site
405416006089	regulatory phosphorylation site [posttranslational modification]; other site
405416006090	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
405416006091	Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080
405416006092	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
405416006093	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
405416006094	Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105
405416006095	1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164
405416006096	putative substrate binding site [chemical binding]; other site
405416006097	putative ATP binding site [chemical binding]; other site
405416006098	PTS system fructose-specific transporter subunits IIBC; Provisional; Region: PRK10712
405416006099	PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569
405416006100	active site
405416006101	P-loop; other site
405416006102	phosphorylation site [posttranslational modification]
405416006103	Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; cl17425
405416006104	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
405416006105	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
405416006106	putative DNA binding site [nucleotide binding]; other site
405416006107	putative Zn2+ binding site [ion binding]; other site
405416006108	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
405416006109	PAS domain; Region: PAS_9; pfam13426
405416006110	putative active site [active]
405416006111	heme pocket [chemical binding]; other site
405416006112	PAS fold; Region: PAS_4; pfam08448
405416006113	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
405416006114	putative active site [active]
405416006115	heme pocket [chemical binding]; other site
405416006116	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
405416006117	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
405416006118	metal binding site [ion binding]; metal-binding site
405416006119	active site
405416006120	I-site; other site
405416006121	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
405416006122	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
405416006123	Ligand Binding Site [chemical binding]; other site
405416006124	dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606
405416006125	Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995
405416006126	Uncharacterized ACR, COG2135; Region: DUF159; pfam02586
405416006127	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
405416006128	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
405416006129	Sulfate transporter family; Region: Sulfate_transp; pfam00916
405416006130	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
405416006131	Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922
405416006132	Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404
405416006133	Peptidase S8 family domain in ProteinaseK-like proteins; Region: Peptidases_S8_PCSK9_ProteinaseK_like; cd04077
405416006134	calcium binding site 2 [ion binding]; other site
405416006135	active site
405416006136	catalytic triad [active]
405416006137	calcium binding site 1 [ion binding]; other site
405416006138	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
405416006139	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
405416006140	Helix-turn-helix domain; Region: HTH_38; pfam13936
405416006141	Homeodomain-like domain; Region: HTH_32; pfam13565
405416006142	Integrase core domain; Region: rve; pfam00665
405416006143	Integrase core domain; Region: rve_3; cl15866
405416006144	Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113
405416006145	Kynureninase [Amino acid transport and metabolism]; Region: COG3844
405416006146	kynureninase; Region: kynureninase; TIGR01814
405416006147	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
405416006148	catalytic residue [active]
405416006149	helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344
405416006150	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
405416006151	putative DNA binding site [nucleotide binding]; other site
405416006152	putative Zn2+ binding site [ion binding]; other site
405416006153	AsnC family; Region: AsnC_trans_reg; pfam01037
405416006154	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
405416006155	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
405416006156	Fels-1 Prophage Protein-like; Region: Fels1; pfam05666
405416006157	Fels-1 Prophage Protein-like; Region: Fels1; pfam05666
405416006158	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915
405416006159	Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419
405416006160	motif II; other site
405416006161	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
405416006162	RNA binding surface [nucleotide binding]; other site
405416006163	recombinase A; Provisional; Region: recA; PRK09354
405416006164	RecA is a  bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response.  RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983
405416006165	hexamer interface [polypeptide binding]; other site
405416006166	Walker A motif; other site
405416006167	ATP binding site [chemical binding]; other site
405416006168	Walker B motif; other site
405416006169	recombination regulator RecX; Reviewed; Region: recX; PRK00117
405416006170	tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795
405416006171	UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289
405416006172	UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351
405416006173	active site
405416006174	FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288
405416006175	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892
405416006176	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613
405416006177	UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352
405416006178	trimer interface [polypeptide binding]; other site
405416006179	active site
405416006180	UDP-GlcNAc binding site [chemical binding]; other site
405416006181	lipid binding site [chemical binding]; lipid-binding site
405416006182	Outer membrane protein (OmpH-like); Region: OmpH; pfam03938
405416006183	outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303
405416006184	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
405416006185	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
405416006186	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
405416006187	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
405416006188	Surface antigen; Region: Bac_surface_Ag; pfam01103
405416006189	zinc metallopeptidase RseP; Provisional; Region: PRK10779
405416006190	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
405416006191	active site
405416006192	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
405416006193	protein binding site [polypeptide binding]; other site
405416006194	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
405416006195	protein binding site [polypeptide binding]; other site
405416006196	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
405416006197	putative substrate binding region [chemical binding]; other site
405416006198	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447
405416006199	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670
405416006200	1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436
405416006201	DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288
405416006202	Cytidylyltransferase family; Region: CTP_transf_1; pfam01148
405416006203	CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575
405416006204	Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255
405416006205	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230
405416006206	putative FPP binding hydrophobic cleft; other site
405416006207	dimer interface [polypeptide binding]; other site
405416006208	putative IPP diphosphate binding site; other site
405416006209	ribosome recycling factor; Reviewed; Region: frr; PRK00083
405416006210	Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation.  Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520
405416006211	hinge region; other site
405416006212	UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254
405416006213	putative nucleotide binding site [chemical binding]; other site
405416006214	uridine monophosphate binding site [chemical binding]; other site
405416006215	homohexameric interface [polypeptide binding]; other site
405416006216	ribosomal protein S12 methylthiotransferase; Provisional; Region: rimO; PRK14862
405416006217	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
405416006218	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
405416006219	FeS/SAM binding site; other site
405416006220	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
405416006221	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
405416006222	putative active site [active]
405416006223	heme pocket [chemical binding]; other site
405416006224	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
405416006225	dimer interface [polypeptide binding]; other site
405416006226	phosphorylation site [posttranslational modification]
405416006227	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
405416006228	ATP binding site [chemical binding]; other site
405416006229	Mg2+ binding site [ion binding]; other site
405416006230	G-X-G motif; other site
405416006231	nitrogen regulation protein NR(I); Region: ntrC; TIGR01818
405416006232	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
405416006233	active site
405416006234	phosphorylation site [posttranslational modification]
405416006235	intermolecular recognition site; other site
405416006236	dimerization interface [polypeptide binding]; other site
405416006237	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
405416006238	Walker A motif; other site
405416006239	ATP binding site [chemical binding]; other site
405416006240	Walker B motif; other site
405416006241	arginine finger; other site
405416006242	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
405416006243	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
405416006244	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
405416006245	ornithine carbamoyltransferase; Provisional; Region: PRK00779
405416006246	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
405416006247	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
405416006248	Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053
405416006249	catalytic residues [active]
405416006250	active site
405416006251	MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554
405416006252	homotrimer interaction site [polypeptide binding]; other site
405416006253	zinc binding site [ion binding]; other site
405416006254	CDP-binding sites; other site
405416006255	D-amino acid dehydrogenase small subunit; Provisional; Region: PRK12409
405416006256	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
405416006257	hydroxyglutarate oxidase; Provisional; Region: PRK11728
405416006258	fumarate hydratase; Reviewed; Region: fumC; PRK00485
405416006259	Class II fumarases; Region: Fumarase_classII; cd01362
405416006260	active site
405416006261	tetramer interface [polypeptide binding]; other site
405416006262	UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087
405416006263	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
405416006264	NAD(P) binding site [chemical binding]; other site
405416006265	active site
405416006266	sulfur relay protein TusD/DsrE; Region: sulf_tusD_dsrE; TIGR03012
405416006267	Dissimilatory sulfite reductase (desulfoviridin), gamma subunit [Inorganic ion transport and metabolism]; Region: DsrC; COG2920
405416006268	DsrC like protein; Region: DsrC; pfam04358
405416006269	EamA-like transporter family; Region: EamA; pfam00892
405416006270	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
405416006271	DNA-binding site [nucleotide binding]; DNA binding site
405416006272	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
405416006273	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
405416006274	pyridoxal 5'-phosphate binding site [chemical binding]; other site
405416006275	homodimer interface [polypeptide binding]; other site
405416006276	catalytic residue [active]
405416006277	Predicted transcriptional regulators [Transcription]; Region: COG1733
405416006278	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
405416006279	Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303
405416006280	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
405416006281	dimer interface [polypeptide binding]; other site
405416006282	putative functional site; other site
405416006283	putative MPT binding site; other site
405416006284	bifunctional molybdenum cofactor biosynthesis protein MoaC/MogA; Provisional; Region: moaC; PRK03604
405416006285	MoaC family. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine derivative to the precursor...; Region: MoaC; cl00242
405416006286	trimer interface [polypeptide binding]; other site
405416006287	dimer interface [polypeptide binding]; other site
405416006288	putative active site [active]
405416006289	MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886
405416006290	MPT binding site; other site
405416006291	trimer interface [polypeptide binding]; other site
405416006292	MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756
405416006293	MoaE homodimer interface [polypeptide binding]; other site
405416006294	MoaD interaction [polypeptide binding]; other site
405416006295	active site residues [active]
405416006296	molybdenum cofactor biosynthesis protein A, bacterial; Region: moaA; TIGR02666
405416006297	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
405416006298	FeS/SAM binding site; other site
405416006299	Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463
405416006300	Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243
405416006301	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
405416006302	molybdopterin cofactor binding site; other site
405416006303	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
405416006304	The MopB_CT_1 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. This CD is of the...; Region: MopB_CT_1; cd02782
405416006305	putative molybdopterin cofactor binding site; other site
405416006306	molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317
405416006307	MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503
405416006308	GTP binding site; other site
405416006309	Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243
405416006310	Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754
405416006311	[4Fe-4S] binding site [ion binding]; other site
405416006312	molybdopterin cofactor binding site; other site
405416006313	Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791
405416006314	molybdopterin cofactor binding site; other site
405416006315	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
405416006316	Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529
405416006317	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992
405416006318	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
405416006319	nitrite reductase subunit NirD; Provisional; Region: PRK14989
405416006320	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
405416006321	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
405416006322	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
405416006323	Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707
405416006324	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
405416006325	active site
405416006326	phosphorylation site [posttranslational modification]
405416006327	intermolecular recognition site; other site
405416006328	dimerization interface [polypeptide binding]; other site
405416006329	ANTAR domain; Region: ANTAR; pfam03861
405416006330	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
405416006331	NMT1-like family; Region: NMT1_2; pfam13379
405416006332	DNA polymerase V subunit UmuC; Reviewed; Region: umuC; PRK03609
405416006333	umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700
405416006334	active site
405416006335	DNA binding site [nucleotide binding]
405416006336	Domain of unknown function (DUF4113); Region: DUF4113; pfam13438
405416006337	Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466
405416006338	Dehydroquinase class II; Region: DHquinase_II; pfam01220
405416006339	trimer interface [polypeptide binding]; other site
405416006340	active site
405416006341	dimer interface [polypeptide binding]; other site
405416006342	acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302
405416006343	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
405416006344	carboxyltransferase (CT) interaction site; other site
405416006345	biotinylation site [posttranslational modification]; other site
405416006346	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
405416006347	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
405416006348	ATP-grasp domain; Region: ATP-grasp_4; cl17255
405416006349	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
405416006350	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
405416006351	putative 3-phenylpropionic acid transporter; Provisional; Region: PRK11128
405416006352	putative substrate translocation pore; other site
405416006353	PAAR motif; Region: PAAR_motif; pfam05488
405416006354	PAAR motif; Region: PAAR_motif; pfam05488
405416006355	TIGR02594 family protein; Region: TIGR02594
405416006356	Helicase_C-like; Region: Helicase_C_4; pfam13871
405416006357	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
405416006358	S-adenosylmethionine binding site [chemical binding]; other site
405416006359	Carbohydrate binding domain; Region: CBM_4_9; pfam02018
405416006360	Domain of unknown function (DUF1983); Region: DUF1983; pfam09327
405416006361	Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026
405416006362	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153
405416006363	P22_AR N-terminal domain; Region: P22_AR_N; pfam10547
405416006364	Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cl17442
405416006365	protein-splicing catalytic site; other site
405416006366	thioester formation/cholesterol transfer; other site
405416006367	Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755
405416006368	putative pectinesterase; Region: PLN02432; cl01911
405416006369	P22_AR N-terminal domain; Region: P22_AR_N; pfam10547
405416006370	Glycine zipper 2TM domain; Region: Rick_17kDa_Anti; cl10470
405416006371	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
405416006372	non-specific DNA binding site [nucleotide binding]; other site
405416006373	salt bridge; other site
405416006374	sequence-specific DNA binding site [nucleotide binding]; other site
405416006375	Endodeoxyribonuclease RusA; Region: RusA; pfam05866
405416006376	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
405416006377	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
405416006378	Walker A motif; other site
405416006379	ATP binding site [chemical binding]; other site
405416006380	Walker B motif; other site
405416006381	arginine finger; other site
405416006382	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
405416006383	Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270
405416006384	cofactor binding site; other site
405416006385	DNA binding site [nucleotide binding]
405416006386	substrate interaction site [chemical binding]; other site
405416006387	HNH endonuclease; Region: HNH_3; pfam13392
405416006388	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
405416006389	MarR family; Region: MarR_2; cl17246
405416006390	Cro/C1-type HTH DNA-binding domain; Region: HTH_26; pfam13443
405416006391	Predicted transcriptional regulator [Transcription]; Region: COG2932
405416006392	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
405416006393	Catalytic site [active]
405416006394	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
405416006395	exodeoxyribonuclease X; Provisional; Region: PRK07983
405416006396	active site
405416006397	catalytic site [active]
405416006398	substrate binding site [chemical binding]; other site
405416006399	Ead/Ea22-like protein; Region: Ead_Ea22; pfam13935
405416006400	Methyltransferase domain; Region: Methyltransf_25; pfam13649
405416006401	S-adenosylmethionine binding site [chemical binding]; other site
405416006402	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
405416006403	active site
405416006404	Int/Topo IB signature motif; other site
405416006405	DNA binding site [nucleotide binding]
405416006406	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
405416006407	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
405416006408	Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182
405416006409	PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703
405416006410	Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069
405416006411	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
405416006412	active site
405416006413	FMN binding site [chemical binding]; other site
405416006414	substrate binding site [chemical binding]; other site
405416006415	3Fe-4S cluster binding site [ion binding]; other site
405416006416	Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267
405416006417	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
405416006418	Uncharacterized conserved protein [Function unknown]; Region: COG1434
405416006419	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
405416006420	putative active site [active]
405416006421	UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK00046
405416006422	FAD binding domain; Region: FAD_binding_4; pfam01565
405416006423	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873
405416006424	Low molecular weight phosphatase family; Region: LMWPc; cd00115
405416006425	Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451
405416006426	active site
405416006427	Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282
405416006428	Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454
405416006429	5-hydroxyvalerate dehydrogenase (HVD) catalyzes the oxidation of 5-hydroxyvalerate to 5-oxovalerate with NAD+ as cofactor; Region: HVD; cd08193
405416006430	putative active site [active]
405416006431	metal binding site [ion binding]; metal-binding site
405416006432	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
405416006433	active site
405416006434	phospholipase C, phosphocholine-specific, Pseudomonas-type; Region: PC_PLC; TIGR03396
405416006435	Phosphoesterase family; Region: Phosphoesterase; pfam04185
405416006436	Domain of unknown function (DUF756); Region: DUF756; pfam05506
405416006437	Domain of unknown function (DUF756); Region: DUF756; pfam05506
405416006438	DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14960
405416006439	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
405416006440	Walker A motif; other site
405416006441	ATP binding site [chemical binding]; other site
405416006442	Walker B motif; other site
405416006443	arginine finger; other site
405416006444	DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169
405416006445	methyl viologen resistance protein SmvA; Provisional; Region: PRK14995
405416006446	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
405416006447	putative substrate translocation pore; other site
405416006448	TetR family transcriptional regulator; Provisional; Region: PRK14996
405416006449	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
405416006450	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
405416006451	Beta-lactamase; Region: Beta-lactamase; pfam00144
405416006452	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
405416006453	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
405416006454	active site 2 [active]
405416006455	active site 1 [active]
405416006456	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08261
405416006457	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
405416006458	NAD(P) binding site [chemical binding]; other site
405416006459	active site
405416006460	acetyl-CoA acetyltransferase; Provisional; Region: PRK09268
405416006461	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
405416006462	dimer interface [polypeptide binding]; other site
405416006463	active site
405416006464	Bacterial Transmembrane Pair family; Region: BTP; pfam05232
405416006465	Bacterial Transmembrane Pair family; Region: BTP; pfam05232
405416006466	Transcriptional regulator [Transcription]; Region: LysR; COG0583
405416006467	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
405416006468	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
405416006469	dimerization interface [polypeptide binding]; other site
405416006470	transaldolase-like protein; Provisional; Region: PTZ00411
405416006471	Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957
405416006472	active site
405416006473	dimer interface [polypeptide binding]; other site
405416006474	catalytic residue [active]
405416006475	leucine export protein LeuE; Provisional; Region: PRK10958
405416006476	leucine-responsive transcriptional regulator; Provisional; Region: PRK11169
405416006477	Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412
405416006478	AsnC family; Region: AsnC_trans_reg; pfam01037
405416006479	Benzoate membrane transport protein; Region: BenE; pfam03594
405416006480	benzoate transporter; Region: benE; TIGR00843
405416006481	Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285
405416006482	MgtC family; Region: MgtC; pfam02308
405416006483	magnesium-transporting ATPase MgtA; Provisional; Region: PRK10517
405416006484	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690
405416006485	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
405416006486	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
405416006487	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
405416006488	RDD family; Region: RDD; pfam06271
405416006489	dipeptidase, putative; Region: dipeptidaselike; TIGR01887
405416006490	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
405416006491	Ligand Binding Site [chemical binding]; other site
405416006492	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
405416006493	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
405416006494	Walker A/P-loop; other site
405416006495	ATP binding site [chemical binding]; other site
405416006496	Q-loop/lid; other site
405416006497	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
405416006498	ABC transporter signature motif; other site
405416006499	Walker B; other site
405416006500	D-loop; other site
405416006501	ABC transporter; Region: ABC_tran_2; pfam12848
405416006502	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
405416006503	Outer membrane protein W [Cell envelope biogenesis, outer membrane]; Region: OmpW; COG3047
405416006504	Outer membrane receptor for ferric coprogen and ferric-rhodotorulic acid [Inorganic ion transport and metabolism]; Region: FhuE; COG4773
405416006505	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
405416006506	N-terminal plug; other site
405416006507	ligand-binding site [chemical binding]; other site
405416006508	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
405416006509	Coenzyme A binding pocket [chemical binding]; other site
405416006510	synaptic vesicle protein SV2; Region: synapt_SV2; TIGR01299
405416006511	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
405416006512	Mechanosensitive ion channel; Region: MS_channel; pfam00924
405416006513	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
405416006514	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
405416006515	N-terminal plug; other site
405416006516	ligand-binding site [chemical binding]; other site
405416006517	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
405416006518	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
405416006519	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
405416006520	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
405416006521	putative DNA binding site [nucleotide binding]; other site
405416006522	putative Zn2+ binding site [ion binding]; other site
405416006523	AsnC family; Region: AsnC_trans_reg; pfam01037
405416006524	chorismate mutase; Provisional; Region: PRK08055
405416006525	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
405416006526	active site
405416006527	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
405416006528	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
405416006529	NAD(P) binding site [chemical binding]; other site
405416006530	active site
405416006531	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
405416006532	Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of  glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570
405416006533	C-terminal domain interface [polypeptide binding]; other site
405416006534	GSH binding site (G-site) [chemical binding]; other site
405416006535	dimer interface [polypeptide binding]; other site
405416006536	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299
405416006537	N-terminal domain interface [polypeptide binding]; other site
405416006538	aminopeptidase N; Provisional; Region: pepN; PRK14015
405416006539	Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_1; cd09600
405416006540	active site
405416006541	Zn binding site [ion binding]; other site
405416006542	4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170
405416006543	substrate binding site [chemical binding]; other site
405416006544	multimerization interface [polypeptide binding]; other site
405416006545	ATP binding site [chemical binding]; other site
405416006546	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
405416006547	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
405416006548	DNA gyrase inhibitor [DNA replication, recombination, and repair]; Region: COG3449
405416006549	5-carboxymethyl-2-hydroxymuconate isomerase (CHMI) is a trimeric enzyme catalyzing the isomerization of the unsaturated ketone 5-(carboxymethyl)-2-hydroxymuconate to 5-(carboxymethyl)-2-oxo-3-hexene-1,6-dionate. This is one step in the...; Region: CHMI; cd00580
405416006550	putative substrate binding pocket [chemical binding]; other site
405416006551	trimer interface [polypeptide binding]; other site
405416006552	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
405416006553	PIF1-like helicase; Region: PIF1; pfam05970
405416006554	Walker A motif; other site
405416006555	ATP binding site [chemical binding]; other site
405416006556	Walker B motif; other site
405416006557	Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176
405416006558	Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454
405416006559	dimer interface [polypeptide binding]; other site
405416006560	active site
405416006561	metal binding site [ion binding]; metal-binding site
405416006562	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
405416006563	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
405416006564	Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862
405416006565	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
405416006566	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
405416006567	NAD(P) binding site [chemical binding]; other site
405416006568	catalytic residues [active]
405416006569	ethanolamine permease; Region: 2A0305; TIGR00908
405416006570	ethanolamine ammonia lyase large subunit; Provisional; Region: PRK15067
405416006571	Ethanolamine ammonia lyase large subunit (EutB); Region: EutB; pfam06751
405416006572	ethanolamine ammonia-lyase small subunit; Provisional; Region: PRK05465
405416006573	GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518
405416006574	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741
405416006575	catalytic triad [active]
405416006576	glutaminyl-tRNA synthetase; Provisional; Region: PRK05347
405416006577	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
405416006578	active site
405416006579	HIGH motif; other site
405416006580	nucleotide binding site [chemical binding]; other site
405416006581	catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807
405416006582	KMSKS motif; other site
405416006583	tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950
405416006584	cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920
405416006585	substrate binding site [chemical binding]; other site
405416006586	Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398
405416006587	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
405416006588	putative active site [active]
405416006589	putative metal binding site [ion binding]; other site
405416006590	NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149
405416006591	dimer interface [polypeptide binding]; other site
405416006592	FMN binding site [chemical binding]; other site
405416006593	EamA-like transporter family; Region: EamA; pfam00892
405416006594	phosphonate utilization associated putative membrane protein; Region: phn_DUF6; TIGR03340
405416006595	bacterial Hfq-like; Region: Hfq; cd01716
405416006596	hexamer interface [polypeptide binding]; other site
405416006597	Sm1 motif; other site
405416006598	RNA binding site [nucleotide binding]; other site
405416006599	Sm2 motif; other site
405416006600	tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324
405416006601	tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091
405416006602	DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095
405416006603	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
405416006604	ATP binding site [chemical binding]; other site
405416006605	Mg2+ binding site [ion binding]; other site
405416006606	G-X-G motif; other site
405416006607	MutL_Trans_MutL: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to Escherichia coli MutL.  EcMutL belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family.  This transducer domain is homologous to the second...; Region: MutL_Trans_MutL; cd03482
405416006608	ATP binding site [chemical binding]; other site
405416006609	MutL C terminal dimerisation domain; Region: MutL_C; pfam08676
405416006610	Uncharacterized P-loop hydrolase UPF0079; Region: UPF0079; cl00520
405416006611	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
405416006612	Pseudouridine synthase, a subgroup of the RluA family; Region: PSRA_1; cd02558
405416006613	probable active site [active]
405416006614	RelB antitoxin; Region: RelB; cl01171
405416006615	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
405416006616	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
405416006617	Coenzyme A binding pocket [chemical binding]; other site
405416006618	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
405416006619	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
405416006620	RNA binding surface [nucleotide binding]; other site
405416006621	Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553
405416006622	active site
405416006623	uracil binding [chemical binding]; other site
405416006624	Protein of unknown function (DUF441); Region: DUF441; pfam04284
405416006625	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
405416006626	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
405416006627	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
405416006628	dimerization interface [polypeptide binding]; other site
405416006629	Domain of unknown function (DUF4198); Region: DUF4198; pfam10670
405416006630	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
405416006631	Major Facilitator Superfamily; Region: MFS_1; pfam07690
405416006632	putative substrate translocation pore; other site
405416006633	Ion transport protein; Region: Ion_trans; pfam00520
405416006634	Ion channel; Region: Ion_trans_2; pfam07885
405416006635	CCC1-related family of proteins; Region: CCC1_like; cl00278
405416006636	bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238
405416006637	Aconitase B swivel domain. Aconitate hydratase B is involved in energy metabolism as part of the TCA cycle. It catalyses the formation of cis-aconitate from citrate. This is the aconitase swivel domain, which undergoes swivelling conformational change in...; Region: AcnB_Swivel; cd01576
405416006638	substrate binding site [chemical binding]; other site
405416006639	Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle; Region: AcnB; cd01581
405416006640	substrate binding site [chemical binding]; other site
405416006641	ligand binding site [chemical binding]; other site
405416006642	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911
405416006643	Family of unknown function (DUF490); Region: DUF490; pfam04357
405416006644	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911
405416006645	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
405416006646	Membrane-fusion protein [Cell envelope biogenesis, outer membrane]; Region: AcrA; COG0845
405416006647	Surface antigen; Region: Bac_surface_Ag; pfam01103
405416006648	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
405416006649	putative substrate translocation pore; other site
405416006650	Demethoxyubiquinone hydroxylase, ferritin-like diiron-binding domain; Region: DMQH; cd01042
405416006651	diiron binding motif [ion binding]; other site
405416006652	Protein of unknown function (DUF2799); Region: DUF2799; pfam10973
405416006653	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
405416006654	Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174
405416006655	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
405416006656	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
405416006657	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
405416006658	active site
405416006659	phosphorylation site [posttranslational modification]
405416006660	intermolecular recognition site; other site
405416006661	dimerization interface [polypeptide binding]; other site
405416006662	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
405416006663	DNA binding site [nucleotide binding]
405416006664	Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205
405416006665	Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702
405416006666	USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987
405416006667	Ligand Binding Site [chemical binding]; other site
405416006668	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
405416006669	dimer interface [polypeptide binding]; other site
405416006670	phosphorylation site [posttranslational modification]
405416006671	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
405416006672	ATP binding site [chemical binding]; other site
405416006673	Mg2+ binding site [ion binding]; other site
405416006674	G-X-G motif; other site
405416006675	potassium-transporting ATPase subunit C; Reviewed; Region: PRK00315
405416006676	potassium-transporting ATPase subunit B; Provisional; Region: PRK01122
405416006677	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
405416006678	Soluble P-type ATPase [General function prediction only]; Region: COG4087
405416006679	potassium-transporting ATPase subunit A; Provisional; Region: PRK05482
405416006680	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cl00233
405416006681	catalytic center binding site [active]
405416006682	ATP binding site [chemical binding]; other site
405416006683	Dihydroneopterin aldolase; Region: FolB; pfam02152
405416006684	active site
405416006685	Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661
405416006686	ABC1 family; Region: ABC1; cl17513
405416006687	molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690
405416006688	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
405416006689	ATP binding site [chemical binding]; other site
405416006690	substrate interface [chemical binding]; other site
405416006691	Flavin reductase like domain; Region: Flavin_Reduct; smart00903
405416006692	Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365
405416006693	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
405416006694	acyl-activating enzyme (AAE) consensus motif; other site
405416006695	AMP binding site [chemical binding]; other site
405416006696	active site
405416006697	CoA binding site [chemical binding]; other site
405416006698	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
405416006699	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
405416006700	active site
405416006701	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08217
405416006702	17hydroxysteroid dehydrogenase type 10 (HSD10)-like, classical (c) SDRs; Region: HSD10-like_SDR_c; cd05371
405416006703	NAD binding site [chemical binding]; other site
405416006704	homodimer interface [polypeptide binding]; other site
405416006705	homotetramer interface [polypeptide binding]; other site
405416006706	active site
405416006707	Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625
405416006708	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
405416006709	SurA N-terminal domain; Region: SurA_N; pfam09312
405416006710	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
405416006711	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
405416006712	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
405416006713	substrate binding pocket [chemical binding]; other site
405416006714	ABC transporter periplasmic binding protein, urea carboxylase region; Region: ABC_peri_uca; TIGR03427
405416006715	membrane-bound complex binding site; other site
405416006716	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
405416006717	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
405416006718	ABC-ATPase subunit interface; other site
405416006719	N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328
405416006720	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
405416006721	peptide chain release factor 1; Validated; Region: prfA; PRK00591
405416006722	This domain is found in peptide chain release factors; Region: PCRF; smart00937
405416006723	RF-1 domain; Region: RF-1; pfam00472
405416006724	Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693
405416006725	Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141
405416006726	potential catalytic triad [active]
405416006727	conserved cys residue [active]
405416006728	Transcriptional regulator [Transcription]; Region: LysR; COG0583
405416006729	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
405416006730	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
405416006731	putative effector binding pocket; other site
405416006732	dimerization interface [polypeptide binding]; other site
405416006733	luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558
405416006734	probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858
405416006735	PgaD-like protein; Region: PgaD; pfam13994
405416006736	N-glycosyltransferase; Provisional; Region: PRK11204
405416006737	CESA_like is  the cellulose synthase superfamily; Region: CESA_like; cd06423
405416006738	DXD motif; other site
405416006739	poly-beta-1,6-N-acetyl-D-glucosamine N-deacetylase PgaB; Region: deacetyl_PgaB; TIGR03938
405416006740	N-terminal putative catalytic polysaccharide deacetylase domain of bacterial poly-beta-1,6-N-acetyl-D-glucosamine N-deacetylase PgaB, and similar proteins; Region: CE4_PgaB_5s; cd10964
405416006741	putative active site [active]
405416006742	putative metal binding site [ion binding]; other site
405416006743	poly-beta-1,6 N-acetyl-D-glucosamine export porin PgaA; Region: PGA_TPR_OMP; TIGR03939
405416006744	poly-beta-1,6 N-acetyl-D-glucosamine export porin PgaA; Region: PGA_TPR_OMP; TIGR03939
405416006745	PEP synthetase regulatory protein; Provisional; Region: PRK05339
405416006746	phosphoenolpyruvate synthase; Validated; Region: PRK06464
405416006747	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
405416006748	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
405416006749	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
405416006750	Domain of unknown function (DUF4339); Region: DUF4339; pfam14237
405416006751	RDD family; Region: RDD; pfam06271
405416006752	cytochrome o ubiquinol oxidase subunit II; Region: CyoA; TIGR01433
405416006753	COX Aromatic Rich Motif; Region: COX_ARM; pfam06481
405416006754	Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843
405416006755	Ubiquinol oxidase subunit I.  Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane.  It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662
405416006756	D-pathway; other site
405416006757	Putative ubiquinol binding site [chemical binding]; other site
405416006758	Low-spin heme (heme b) binding site [chemical binding]; other site
405416006759	Putative water exit pathway; other site
405416006760	Binuclear center (heme o3/CuB) [ion binding]; other site
405416006761	K-pathway; other site
405416006762	Putative proton exit pathway; other site
405416006763	Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane.  It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863
405416006764	Subunit I/III interface [polypeptide binding]; other site
405416006765	Subunit III/IV interface [polypeptide binding]; other site
405416006766	cytochrome o ubiquinol oxidase subunit IV; Provisional; Region: PRK10582
405416006767	protoheme IX farnesyltransferase; Provisional; Region: PRK04375
405416006768	UbiA prenyltransferase family; Region: UbiA; pfam01040
405416006769	30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453
405416006770	30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391
405416006771	50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137
405416006772	Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281
405416006773	Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948
405416006774	replicative DNA helicase; Region: DnaB; TIGR00665
405416006775	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
405416006776	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
405416006777	Walker A motif; other site
405416006778	ATP binding site [chemical binding]; other site
405416006779	Walker B motif; other site
405416006780	DNA binding loops [nucleotide binding]
405416006781	alanine racemase; Reviewed; Region: alr; PRK00053
405416006782	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827
405416006783	active site
405416006784	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
405416006785	substrate binding site [chemical binding]; other site
405416006786	catalytic residues [active]
405416006787	dimer interface [polypeptide binding]; other site
405416006788	Predicted proteasome-type protease [Posttranslational modification, protein turnover, chaperones]; Region: COG3484
405416006789	Bacterial proteasome, beta subunit. The 20S proteasome, multisubunit proteolytic complex, is the central enzyme of nonlysosomal protein degradation in both the cytosol and nucleus. It is composed of 28 subunits arranged as four homoheptameric rings that...; Region: proteasome_beta_bacterial; cd03765
405416006790	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
405416006791	Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379
405416006792	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
405416006793	A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168
405416006794	Uncharacterized conserved protein [Function unknown]; Region: COG2308
405416006795	Predicted transcriptional regulator [Transcription]; Region: COG2378
405416006796	WYL domain; Region: WYL; pfam13280
405416006797	tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192
405416006798	NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206
405416006799	GidA associated domain 3; Region: GIDA_assoc_3; pfam13932
405416006800	Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325
405416006801	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
405416006802	S-adenosylmethionine binding site [chemical binding]; other site
405416006803	MJ0042 family finger-like domain; Region: MJ0042_CXXC; TIGR02098
405416006804	Protein of unknown function (DUF3426); Region: DUF3426; pfam11906
405416006805	Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420
405416006806	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881
405416006807	Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal  ATIC formylase domain that formylates...; Region: IMPCH; cd01421
405416006808	purine monophosphate binding site [chemical binding]; other site
405416006809	dimer interface [polypeptide binding]; other site
405416006810	putative catalytic residues [active]
405416006811	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798
405416006812	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362
405416006813	phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885
405416006814	Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844
405416006815	Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071
405416006816	Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843
405416006817	ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464
405416006818	NLPA lipoprotein; Region: Lipoprotein_9; pfam03180
405416006819	DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153
405416006820	ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258
405416006821	Walker A/P-loop; other site
405416006822	ATP binding site [chemical binding]; other site
405416006823	Q-loop/lid; other site
405416006824	ABC transporter signature motif; other site
405416006825	Walker B; other site
405416006826	D-loop; other site
405416006827	H-loop/switch region; other site
405416006828	NIL domain; Region: NIL; pfam09383
405416006829	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
405416006830	dimer interface [polypeptide binding]; other site
405416006831	conserved gate region; other site
405416006832	ABC-ATPase subunit interface; other site
405416006833	hydroxyacylglutathione hydrolase; Region: GSH_gloB; TIGR03413
405416006834	C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663
405416006835	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
405416006836	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
405416006837	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
405416006838	multidrug resistance protein D; Provisional; Region: emrD; PRK11652
405416006839	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
405416006840	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
405416006841	Coenzyme A binding pocket [chemical binding]; other site
405416006842	Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133
405416006843	aromatic amino acid exporter; Provisional; Region: PRK11689
405416006844	EamA-like transporter family; Region: EamA; pfam00892
405416006845	Aspartate racemase [Cell envelope biogenesis, outer membrane]; Region: RacX; COG1794
405416006846	aspartate racemase; Region: asp_race; TIGR00035
405416006847	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3009
405416006848	Protein of unknown function (DUF330); Region: DUF330; pfam03886
405416006849	mce related protein; Region: MCE; pfam02470
405416006850	mce related protein; Region: MCE; pfam02470
405416006851	mce related protein; Region: MCE; pfam02470
405416006852	Uncharacterized paraquat-inducible protein A [Function unknown]; Region: PqiA; COG2995
405416006853	Paraquat-inducible protein A; Region: PqiA; pfam04403
405416006854	Paraquat-inducible protein A; Region: PqiA; pfam04403
405416006855	aspartate-alanine antiporter; Region: Asp_Ala_antiprt; TIGR03802
405416006856	Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826
405416006857	TrkA-C domain; Region: TrkA_C; pfam02080
405416006858	TrkA-C domain; Region: TrkA_C; pfam02080
405416006859	Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826
405416006860	aspartate 4-decarboxylase; Region: asp_4_decarbox; TIGR03801
405416006861	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
405416006862	pyridoxal 5'-phosphate binding site [chemical binding]; other site
405416006863	homodimer interface [polypeptide binding]; other site
405416006864	catalytic residue [active]
405416006865	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
405416006866	EamA-like transporter family; Region: EamA; pfam00892
405416006867	EamA-like transporter family; Region: EamA; pfam00892
405416006868	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
405416006869	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
405416006870	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
405416006871	putative substrate translocation pore; other site
405416006872	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
405416006873	Osmosensory transporter coiled coil; Region: Osmo_CC; pfam08946
405416006874	Spore Coat Protein U domain; Region: SCPU; cl02253
405416006875	Spore Coat Protein U domain; Region: SCPU; pfam05229
405416006876	P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188
405416006877	Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577
405416006878	PapC C-terminal domain; Region: PapC_C; pfam13953
405416006879	P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121
405416006880	Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345
405416006881	Spore Coat Protein U domain; Region: SCPU; pfam05229
405416006882	Spore Coat Protein U domain; Region: SCPU; cl02253
405416006883	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
405416006884	Helix-turn-helix domain; Region: HTH_38; pfam13936
405416006885	Homeodomain-like domain; Region: HTH_32; pfam13565
405416006886	Integrase core domain; Region: rve; pfam00665
405416006887	Integrase core domain; Region: rve_3; cl15866
405416006888	Spore Coat Protein U domain; Region: SCPU; pfam05229
405416006889	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
405416006890	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
405416006891	Transcriptional regulators [Transcription]; Region: FadR; COG2186
405416006892	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
405416006893	DNA-binding site [nucleotide binding]; DNA binding site
405416006894	FCD domain; Region: FCD; pfam07729
405416006895	Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG2607
405416006896	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
405416006897	Walker A motif; other site
405416006898	ATP binding site [chemical binding]; other site
405416006899	Walker B motif; other site
405416006900	Na+/glutamate symporter [Amino acid transport and metabolism]; Region: GltS; COG0786
405416006901	Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167
405416006902	alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561
405416006903	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
405416006904	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
405416006905	Helix-turn-helix domain; Region: HTH_18; pfam12833
405416006906	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
405416006907	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
405416006908	Sensors of blue-light using FAD; Region: BLUF; pfam04940
405416006909	Bacterial OB fold (BOF) protein; Region: BOF; cl01196
405416006910	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
405416006911	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
405416006912	active site
405416006913	Methyltransferase domain; Region: Methyltransf_31; pfam13847
405416006914	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
405416006915	S-adenosylmethionine binding site [chemical binding]; other site
405416006916	GlcNAc-PI de-N-acetylase; Region: PIG-L; pfam02585
405416006917	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
405416006918	active site
405416006919	Uncharacterized protein conserved in bacteria (DUF2171); Region: DUF2171; pfam09939
405416006920	gamma-aminobutyrate permease; Region: GABAperm; TIGR01773
405416006921	Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085
405416006922	methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722
405416006923	tetrameric interface [polypeptide binding]; other site
405416006924	NAD binding site [chemical binding]; other site
405416006925	catalytic residues [active]
405416006926	beta alanine--pyruvate transaminase; Provisional; Region: PRK09221
405416006927	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
405416006928	inhibitor-cofactor binding pocket; inhibition site
405416006929	pyridoxal 5'-phosphate binding site [chemical binding]; other site
405416006930	catalytic residue [active]
405416006931	Transcriptional regulator [Transcription]; Region: LysR; COG0583
405416006932	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
405416006933	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
405416006934	dimerization interface [polypeptide binding]; other site
405416006935	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
405416006936	substrate binding site [chemical binding]; other site
405416006937	activation loop (A-loop); other site
405416006938	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
405416006939	Domain of unknown function (DUF3336); Region: DUF3336; pfam11815
405416006940	Triacylglycerol lipase 3, 4, and 5 and Sugar-Dependent 1 lipase; Region: Pat_TGL3-4-5_SDP1; cd07206
405416006941	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752
405416006942	active site
405416006943	nucleophile elbow; other site
405416006944	Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG2607
405416006945	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
405416006946	Walker A motif; other site
405416006947	ATP binding site [chemical binding]; other site
405416006948	Walker B motif; other site
405416006949	UGMP family protein; Validated; Region: PRK09604
405416006950	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
405416006951	30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270
405416006952	Yqey-like protein; Region: YqeY; pfam09424
405416006953	Putative Zn-dependent protease, contains TPR repeats [General function prediction only]; Region: COG4783
405416006954	Peptidase family M48; Region: Peptidase_M48; cl12018
405416006955	bifunctional glyoxylate/hydroxypyruvate reductase B; Provisional; Region: PRK15409
405416006956	D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301
405416006957	dimerization interface [polypeptide binding]; other site
405416006958	ligand binding site [chemical binding]; other site
405416006959	NADP binding site [chemical binding]; other site
405416006960	catalytic site [active]
405416006961	Peptidase family M48; Region: Peptidase_M48; cl12018
405416006962	amidophosphoribosyltransferase; Provisional; Region: PRK09246
405416006963	Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319
405416006964	active site
405416006965	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
405416006966	active site
405416006967	Colicin V production protein; Region: Colicin_V; pfam02674
405416006968	dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286
405416006969	Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738
405416006970	quinone interaction residues [chemical binding]; other site
405416006971	active site
405416006972	catalytic residues [active]
405416006973	FMN binding site [chemical binding]; other site
405416006974	substrate binding site [chemical binding]; other site
405416006975	Type II secretion system (T2SS), protein M; Region: T2SM; cl01222
405416006976	Type II secretion system (T2SS), protein L; Region: T2SL; pfam05134
405416006977	GspL periplasmic domain; Region: GspL_C; cl14909
405416006978	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
405416006979	catalytic core [active]
405416006980	NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094
405416006981	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
405416006982	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
405416006983	Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135
405416006984	putative FMN binding site [chemical binding]; other site
405416006985	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
405416006986	DEAD-like helicases superfamily; Region: DEXDc; smart00487
405416006987	ATP binding site [chemical binding]; other site
405416006988	Mg++ binding site [ion binding]; other site
405416006989	motif III; other site
405416006990	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
405416006991	nucleotide binding region [chemical binding]; other site
405416006992	ATP-binding site [chemical binding]; other site
405416006993	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
405416006994	DNA-binding site [nucleotide binding]; DNA binding site
405416006995	RNA-binding motif; other site
405416006996	SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain.  SirA (also known as UvrY,  and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291
405416006997	CPxP  motif; other site
405416006998	RNA polymerase factor sigma-32; Reviewed; Region: PRK06596
405416006999	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
405416007000	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
405416007001	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
405416007002	DNA binding residues [nucleotide binding]
405416007003	Uncharacterized small membrane protein [Function unknown]; Region: COG2363
405416007004	ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565
405416007005	thiS-thiF/thiG interaction site; other site
405416007006	Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728
405416007007	ThiS interaction site; other site
405416007008	putative active site [active]
405416007009	tetramer interface [polypeptide binding]; other site
405416007010	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4339
405416007011	hypothetical protein; Validated; Region: PRK02101
405416007012	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2945
405416007013	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
405416007014	Xaa-His dipeptidase; Region: aa-his-dipept; TIGR01893
405416007015	M20 Peptidase D has specificity for beta-alanyl-L-histidine dipeptide; Region: M20_pepD; cd03890
405416007016	metal binding site [ion binding]; metal-binding site
405416007017	dimer interface [polypeptide binding]; other site
405416007018	bifunctional cyclohexadienyl dehydrogenase/ 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK14806
405416007019	prephenate dehydrogenase; Validated; Region: PRK08507
405416007020	EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556
405416007021	hinge; other site
405416007022	active site
405416007023	Chorismate mutase type II; Region: CM_2; cl00693
405416007024	Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077
405416007025	Prephenate dehydratase; Region: PDT; pfam00800
405416007026	C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905
405416007027	putative L-Phe binding site [chemical binding]; other site
405416007028	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819
405416007029	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
405416007030	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
405416007031	active site
405416007032	C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663
405416007033	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
405416007034	hypothetical protein; Validated; Region: PRK09071
405416007035	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
405416007036	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
405416007037	Protein of unknown function (DUF1315); Region: DUF1315; pfam07023
405416007038	inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK01231
405416007039	inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02231
405416007040	penicillin-binding protein 1B; Region: PBP_1b; TIGR02071
405416007041	Transglycosylase; Region: Transgly; pfam00912
405416007042	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
405416007043	hypothetical protein; Provisional; Region: PRK08999
405416007044	The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425
405416007045	active site
405416007046	8-oxo-dGMP binding site [chemical binding]; other site
405416007047	nudix motif; other site
405416007048	metal binding site [ion binding]; metal-binding site
405416007049	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
405416007050	thiamine phosphate binding site [chemical binding]; other site
405416007051	active site
405416007052	Hemin uptake protein hemP; Region: hemP; cl10043
405416007053	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
405416007054	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
405416007055	dimer interface [polypeptide binding]; other site
405416007056	phosphorylation site [posttranslational modification]
405416007057	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
405416007058	ATP binding site [chemical binding]; other site
405416007059	Mg2+ binding site [ion binding]; other site
405416007060	G-X-G motif; other site
405416007061	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
405416007062	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
405416007063	active site
405416007064	phosphorylation site [posttranslational modification]
405416007065	intermolecular recognition site; other site
405416007066	dimerization interface [polypeptide binding]; other site
405416007067	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
405416007068	DNA binding site [nucleotide binding]
405416007069	Bacterial OB fold (BOF) protein; Region: BOF; cl01196
405416007070	Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157
405416007071	Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804
405416007072	PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129
405416007073	Walker A motif; other site
405416007074	ATP binding site [chemical binding]; other site
405416007075	Walker B motif; other site
405416007076	Predicted membrane protein [Function unknown]; Region: COG3174
405416007077	Domain of unknown function (DUF4010); Region: DUF4010; pfam13194
405416007078	Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281
405416007079	homodimer interaction site [polypeptide binding]; other site
405416007080	cofactor binding site; other site
405416007081	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
405416007082	Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195
405416007083	FAD binding pocket [chemical binding]; other site
405416007084	FAD binding motif [chemical binding]; other site
405416007085	phosphate binding motif [ion binding]; other site
405416007086	beta-alpha-beta structure motif; other site
405416007087	NAD binding pocket [chemical binding]; other site
405416007088	Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384
405416007089	hydroxyproline-2-epimerase; Provisional; Region: PRK13971
405416007090	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
405416007091	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
405416007092	DNA-binding site [nucleotide binding]; DNA binding site
405416007093	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
405416007094	pyridoxal 5'-phosphate binding site [chemical binding]; other site
405416007095	homodimer interface [polypeptide binding]; other site
405416007096	catalytic residue [active]
405416007097	putative protease; Provisional; Region: PRK15452
405416007098	Peptidase family U32; Region: Peptidase_U32; pfam01136
405416007099	archaeoflavoprotein, MJ0208 family; Region: flavo_MJ0208; TIGR02700
405416007100	Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076
405416007101	ABC-type histidine transport system, ATPase component [Amino acid transport and metabolism]; Region: HisP; COG4598
405416007102	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
405416007103	Walker A/P-loop; other site
405416007104	ATP binding site [chemical binding]; other site
405416007105	Q-loop/lid; other site
405416007106	ABC transporter signature motif; other site
405416007107	Walker B; other site
405416007108	D-loop; other site
405416007109	H-loop/switch region; other site
405416007110	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
405416007111	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
405416007112	dimer interface [polypeptide binding]; other site
405416007113	conserved gate region; other site
405416007114	putative PBP binding loops; other site
405416007115	ABC-ATPase subunit interface; other site
405416007116	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
405416007117	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
405416007118	dimer interface [polypeptide binding]; other site
405416007119	conserved gate region; other site
405416007120	putative PBP binding loops; other site
405416007121	ABC-ATPase subunit interface; other site
405416007122	lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096
405416007123	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
405416007124	substrate binding pocket [chemical binding]; other site
405416007125	membrane-bound complex binding site; other site
405416007126	hinge residues; other site
405416007127	Transcriptional regulator [Transcription]; Region: LysR; COG0583
405416007128	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
405416007129	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472
405416007130	putative effector binding pocket; other site
405416007131	putative dimerization interface [polypeptide binding]; other site
405416007132	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
405416007133	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
405416007134	HlyD family secretion protein; Region: HlyD_3; pfam13437
405416007135	AcrB/AcrD/AcrF family; Region: ACR_tran; pfam00873
405416007136	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
405416007137	serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011
405416007138	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
405416007139	dimer interface [polypeptide binding]; other site
405416007140	active site
405416007141	glycine-pyridoxal phosphate binding site [chemical binding]; other site
405416007142	folate binding site [chemical binding]; other site
405416007143	Family of unknown function (DUF695); Region: DUF695; pfam05117
405416007144	Protein of unknown function (DUF1260); Region: DUF1260; pfam06877
405416007145	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
405416007146	Secretory lipase; Region: LIP; pfam03583
405416007147	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
405416007148	exodeoxyribonuclease X; Provisional; Region: PRK07983
405416007149	active site
405416007150	catalytic site [active]
405416007151	substrate binding site [chemical binding]; other site
405416007152	Protein of unknown function (DUF3820); Region: DUF3820; cl01411
405416007153	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
405416007154	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
405416007155	Walker A/P-loop; other site
405416007156	ATP binding site [chemical binding]; other site
405416007157	Q-loop/lid; other site
405416007158	ABC transporter signature motif; other site
405416007159	Walker B; other site
405416007160	D-loop; other site
405416007161	H-loop/switch region; other site
405416007162	inner membrane transport permease; Provisional; Region: PRK15066
405416007163	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
405416007164	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2904
405416007165	7-cyano-7-deazaguanine reductase; Provisional; Region: queF; PRK11792
405416007166	Enzyme related to GTP cyclohydrolase I [General function prediction only]; Region: COG0780
405416007167	rod shape-determining protein RodA; Region: rodA_shape; TIGR02210
405416007168	Transglycosylase SLT domain; Region: SLT_2; pfam13406
405416007169	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
405416007170	N-acetyl-D-glucosamine binding site [chemical binding]; other site
405416007171	catalytic residue [active]
405416007172	Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797
405416007173	Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330
405416007174	Protein of unknown function (DUF962); Region: DUF962; cl01879
405416007175	Branched-chain amino acid transport protein (AzlD); Region: AzlD; pfam05437
405416007176	AzlC protein; Region: AzlC; cl00570
405416007177	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
405416007178	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
405416007179	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
405416007180	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
405416007181	Protein of unknown function (DUF3465); Region: DUF3465; pfam11948
405416007182	elongation factor Ts; Provisional; Region: tsf; PRK09377
405416007183	UBA/TS-N domain; Region: UBA; pfam00627
405416007184	Elongation factor TS; Region: EF_TS; pfam00889
405416007185	Elongation factor TS; Region: EF_TS; pfam00889
405416007186	Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425
405416007187	rRNA interaction site [nucleotide binding]; other site
405416007188	S8 interaction site; other site
405416007189	putative laminin-1 binding site; other site
405416007190	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
405416007191	active site
405416007192	Outer membrane protein W [Cell envelope biogenesis, outer membrane]; Region: OmpW; COG3047
405416007193	nitrite extrusion protein (nitrite facilitator); Region: 2A0108; TIGR00886
405416007194	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
405416007195	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
405416007196	Major Facilitator Superfamily; Region: MFS_1; pfam07690
405416007197	putative substrate translocation pore; other site
405416007198	leucine-responsive transcriptional regulator; Provisional; Region: PRK11169
405416007199	soluble pyridine nucleotide transhydrogenase; Provisional; Region: PRK05249
405416007200	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
405416007201	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
405416007202	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
405416007203	lipoyl synthase; Provisional; Region: PRK05481
405416007204	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
405416007205	FeS/SAM binding site; other site
405416007206	acyl-CoA dehydrogenase; Reviewed; Region: fadE; PRK09463
405416007207	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
405416007208	active site
405416007209	Domain of unknown function (DUF1974); Region: DUF1974; pfam09317
405416007210	Carboxymuconolactone decarboxylase family; Region: CMD; cl00460
405416007211	Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296
405416007212	S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476
405416007213	S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401
405416007214	homotetramer interface [polypeptide binding]; other site
405416007215	ligand binding site [chemical binding]; other site
405416007216	catalytic site [active]
405416007217	NAD binding site [chemical binding]; other site
405416007218	Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537
405416007219	FAD binding site [chemical binding]; other site
405416007220	16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713
405416007221	RNA methyltransferase, RsmE family; Region: TIGR00046
405416007222	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
405416007223	PAS fold; Region: PAS_3; pfam08447
405416007224	heme pocket [chemical binding]; other site
405416007225	putative active site [active]
405416007226	PAS domain S-box; Region: sensory_box; TIGR00229
405416007227	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
405416007228	putative active site [active]
405416007229	heme pocket [chemical binding]; other site
405416007230	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
405416007231	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
405416007232	metal binding site [ion binding]; metal-binding site
405416007233	active site
405416007234	I-site; other site
405416007235	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
405416007236	bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed; Region: PRK07232
405416007237	Malic enzyme, N-terminal domain; Region: malic; pfam00390
405416007238	NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311
405416007239	putative NAD(P) binding site [chemical binding]; other site
405416007240	Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280
405416007241	multifunctional tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase; Reviewed; Region: cca; PRK10885
405416007242	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
405416007243	active site
405416007244	NTP binding site [chemical binding]; other site
405416007245	metal binding triad [ion binding]; metal-binding site
405416007246	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
405416007247	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
405416007248	Zn2+ binding site [ion binding]; other site
405416007249	Mg2+ binding site [ion binding]; other site
405416007250	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
405416007251	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
405416007252	protein binding site [polypeptide binding]; other site
405416007253	NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371
405416007254	Uncharacterized conserved protein [Function unknown]; Region: COG0327
405416007255	Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605
405416007256	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
405416007257	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
405416007258	Protein of unknown function (DUF2726); Region: DUF2726; pfam10881
405416007259	Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506
405416007260	4-hydroxybenzoate octaprenyltransferase; Reviewed; Region: ubiA; PRK12848
405416007261	UbiA prenyltransferase family; Region: UbiA; pfam01040
405416007262	Chorismate lyase; Region: Chor_lyase; cl01230
405416007263	glutamine synthetase; Provisional; Region: glnA; PRK09469
405416007264	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
405416007265	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
405416007266	Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104
405416007267	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
405416007268	putative substrate translocation pore; other site
405416007269	POT family; Region: PTR2; cl17359
405416007270	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl17904
405416007271	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
405416007272	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
405416007273	X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP; cd01085
405416007274	active site
405416007275	para-aminobenzoate synthase component II; Provisional; Region: PRK08857
405416007276	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
405416007277	glutamine binding [chemical binding]; other site
405416007278	catalytic triad [active]
405416007279	Peptidase family M1; Region: Peptidase_M1; pfam01433
405416007280	Peptidase M1 Aminopeptidase N family incudes tricorn interacting factor F3, Endoplasmic reticulum aminopeptidase 1 (ERAP1), Aminopeptidase Q (APQ); Region: M1_APN_2; cd09601
405416007281	Zn binding site [ion binding]; other site
405416007282	Domain of unknown function (DUF3358); Region: DUF3358; pfam11838
405416007283	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
405416007284	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
405416007285	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
405416007286	anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188
405416007287	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
405416007288	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
405416007289	Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331
405416007290	active site
405416007291	ribulose/triose binding site [chemical binding]; other site
405416007292	phosphate binding site [ion binding]; other site
405416007293	substrate (anthranilate) binding pocket [chemical binding]; other site
405416007294	product (indole) binding pocket [chemical binding]; other site
405416007295	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2840
405416007296	Smr domain; Region: Smr; pfam01713
405416007297	XdhC and CoxI family; Region: XdhC_CoxI; pfam02625
405416007298	xanthine dehydrogenase accessory protein XdhC; Region: xanthine_xdhC; TIGR02964
405416007299	XdhC Rossmann domain; Region: XdhC_C; pfam13478
405416007300	xanthine dehydrogenase, molybdopterin binding subunit; Region: xanthine_xdhB; TIGR02965
405416007301	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
405416007302	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
405416007303	xanthine dehydrogenase, small subunit; Region: xanthine_xdhA; TIGR02963
405416007304	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085
405416007305	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
405416007306	CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450
405416007307	GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate.  The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria.  In...; Region: GTP_cyclohydro1; cd00642
405416007308	homodecamer interface [polypeptide binding]; other site
405416007309	GTP cyclohydrolase I; Provisional; Region: PLN03044
405416007310	active site
405416007311	putative catalytic site residues [active]
405416007312	zinc binding site [ion binding]; other site
405416007313	GTP-CH-I/GFRP interaction surface; other site
405416007314	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
405416007315	Helix-turn-helix domain; Region: HTH_38; pfam13936
405416007316	Homeodomain-like domain; Region: HTH_32; pfam13565
405416007317	Integrase core domain; Region: rve; pfam00665
405416007318	Integrase core domain; Region: rve_3; cl15866
405416007319	beta-lactamase/D-alanine carboxypeptidase; Provisional; Region: ampC; PRK11289
405416007320	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
405416007321	Domain of unknown function (DUF4105); Region: DUF4105; pfam13387
405416007322	Protein of unknown function (DUF3015); Region: DUF3015; pfam11220
405416007323	Protein of unknown function (DUF817); Region: DUF817; pfam05675
405416007324	Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717
405416007325	substrate binding site [chemical binding]; other site
405416007326	active site
405416007327	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
405416007328	Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409
405416007329	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
405416007330	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
405416007331	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
405416007332	4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648
405416007333	Thioesterase domain; Region: Thioesterase; pfam00975
405416007334	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
405416007335	putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608
405416007336	Walker A/P-loop; other site
405416007337	ATP binding site [chemical binding]; other site
405416007338	Q-loop/lid; other site
405416007339	ABC transporter signature motif; other site
405416007340	Walker B; other site
405416007341	D-loop; other site
405416007342	H-loop/switch region; other site
405416007343	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
405416007344	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
405416007345	Walker A/P-loop; other site
405416007346	ATP binding site [chemical binding]; other site
405416007347	Q-loop/lid; other site
405416007348	ABC transporter signature motif; other site
405416007349	Walker B; other site
405416007350	D-loop; other site
405416007351	H-loop/switch region; other site
405416007352	histidine decarboxylase; Provisional; Region: PRK02769
405416007353	Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155
405416007354	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
405416007355	catalytic residue [active]
405416007356	Isochorismatase, also known as 2,3 dihydro-2,3 dihydroxybenzoate synthase, catalyses the conversion of isochorismate, in the presence of water, to 2,3-dihydroxybenzoate and pyruvate, via the hydrolysis of a vinyl ether, an uncommon reaction in biological...; Region: isochorismatase; cd01013
405416007357	hydrophobic substrate binding pocket; other site
405416007358	Isochorismatase family; Region: Isochorismatase; pfam00857
405416007359	active site
405416007360	conserved cis-peptide bond; other site
405416007361	Aryl carrier domain [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3433
405416007362	enterobactin synthase subunit E; Provisional; Region: entE; PRK10946
405416007363	2,3-dihydroxybenzoate-AMP ligase; Region: 23DHB-AMP_lg; cd05920
405416007364	acyl-activating enzyme (AAE) consensus motif; other site
405416007365	active site
405416007366	AMP binding site [chemical binding]; other site
405416007367	substrate binding site [chemical binding]; other site
405416007368	Condensation domain; Region: Condensation; pfam00668
405416007369	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
405416007370	Nonribosomal peptide synthase; Region: NRPS; pfam08415
405416007371	Condensation domain; Region: Condensation; pfam00668
405416007372	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
405416007373	Nonribosomal peptide synthase; Region: NRPS; pfam08415
405416007374	Lysine/ornithine N-monooxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: IucD; COG3486
405416007375	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
405416007376	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
405416007377	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
405416007378	N-terminal plug; other site
405416007379	ligand-binding site [chemical binding]; other site
405416007380	ABC-type enterochelin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: CeuA; COG4607
405416007381	Siderophore binding protein FatB.  These proteins have been shown to function as ABC-type initial receptors in the siderophore-mediated iron uptake in some eubacterial species.  They belong to the TroA superfamily of periplasmic metal binding proteins...; Region: FatB; cd01140
405416007382	putative ligand binding residues [chemical binding]; other site
405416007383	ABC-type enterochelin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CeuD; COG4604
405416007384	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
405416007385	Walker A/P-loop; other site
405416007386	ATP binding site [chemical binding]; other site
405416007387	Q-loop/lid; other site
405416007388	ABC transporter signature motif; other site
405416007389	Walker B; other site
405416007390	D-loop; other site
405416007391	H-loop/switch region; other site
405416007392	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
405416007393	ABC-ATPase subunit  interface; other site
405416007394	dimer interface [polypeptide binding]; other site
405416007395	putative PBP binding regions; other site
405416007396	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
405416007397	ABC-ATPase subunit  interface; other site
405416007398	dimer interface [polypeptide binding]; other site
405416007399	putative PBP binding regions; other site
405416007400	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
405416007401	Condensation domain; Region: Condensation; pfam00668
405416007402	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
405416007403	The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; Region: A_NRPS_TlmIV_like; cd12114
405416007404	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
405416007405	acyl-activating enzyme (AAE) consensus motif; other site
405416007406	AMP binding site [chemical binding]; other site
405416007407	Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375
405416007408	Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193
405416007409	FAD binding pocket [chemical binding]; other site
405416007410	FAD binding motif [chemical binding]; other site
405416007411	phosphate binding motif [ion binding]; other site
405416007412	NAD binding pocket [chemical binding]; other site
405416007413	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964
405416007414	YheO-like PAS domain; Region: PAS_6; pfam08348
405416007415	HTH domain; Region: HTH_22; pfam13309
405416007416	Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342
405416007417	catalytic residue [active]
405416007418	Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342
405416007419	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
405416007420	Pirin-related protein [General function prediction only]; Region: COG1741
405416007421	Pirin; Region: Pirin; pfam02678
405416007422	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
405416007423	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
405416007424	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
405416007425	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
405416007426	Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR9; cd08274
405416007427	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
405416007428	putative NAD(P) binding site [chemical binding]; other site
405416007429	L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948
405416007430	Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188
405416007431	metal binding site [ion binding]; metal-binding site
405416007432	substrate binding pocket [chemical binding]; other site
405416007433	Sugar (and other) transporter; Region: Sugar_tr; pfam00083
405416007434	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
405416007435	putative substrate translocation pore; other site
405416007436	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
405416007437	Antitoxin of toxin-antitoxin stability system N-terminal; Region: RelB_N; pfam12910
405416007438	EamA-like transporter family; Region: EamA; pfam00892
405416007439	EamA-like transporter family; Region: EamA; pfam00892
405416007440	aromatic amino acid exporter; Provisional; Region: PRK11689
405416007441	Multiple antibiotic transporter [Intracellular trafficking and secretion]; Region: MarC; COG2095
405416007442	ethanolamine utilization protein EutQ; Provisional; Region: PRK15457
405416007443	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
405416007444	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
405416007445	Rubredoxin [Energy production and conversion]; Region: COG1773
405416007446	Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730
405416007447	iron binding site [ion binding]; other site
405416007448	NADH:flavorubredoxin oxidoreductase; Provisional; Region: PRK04965
405416007449	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
405416007450	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
405416007451	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
405416007452	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
405416007453	NAD(P) binding site [chemical binding]; other site
405416007454	catalytic residues [active]
405416007455	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
405416007456	Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469
405416007457	[2Fe-2S] cluster binding site [ion binding]; other site
405416007458	C-terminal catalytic domain of the oxygenase alpha subunit of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C; cd00680
405416007459	alpha subunit interface [polypeptide binding]; other site
405416007460	active site
405416007461	substrate binding site [chemical binding]; other site
405416007462	Fe binding site [ion binding]; other site
405416007463	BCCT family transporter; Region: BCCT; pfam02028
405416007464	BCCT family transporter; Region: BCCT; pfam02028
405416007465	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
405416007466	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
405416007467	The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432
405416007468	dimerization interface [polypeptide binding]; other site
405416007469	substrate binding pocket [chemical binding]; other site
405416007470	Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113
405416007471	Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085
405416007472	methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722
405416007473	tetrameric interface [polypeptide binding]; other site
405416007474	NAD binding site [chemical binding]; other site
405416007475	catalytic residues [active]
405416007476	Protein of unknown function (DUF861); Region: Cupin_3; pfam05899
405416007477	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
405416007478	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
405416007479	Purine catabolism regulatory protein-like family; Region: PucR; pfam07905
405416007480	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
405416007481	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
405416007482	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
405416007483	Phage antirepressor protein KilAC domain; Region: ANT; cl01462
405416007484	Protein of unknown function (DUF466); Region: DUF466; pfam04328
405416007485	carbon starvation protein A; Provisional; Region: PRK15015
405416007486	Carbon starvation protein CstA; Region: CstA; pfam02554
405416007487	C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722
405416007488	elongation factor P; Validated; Region: PRK00529
405416007489	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
405416007490	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
405416007491	RNA binding site [nucleotide binding]; other site
405416007492	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
405416007493	RNA binding site [nucleotide binding]; other site
405416007494	Radical SAM superfamily; Region: Radical_SAM; pfam04055
405416007495	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
405416007496	FeS/SAM binding site; other site
405416007497	PAS domain S-box; Region: sensory_box; TIGR00229
405416007498	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cl00290
405416007499	50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019
405416007500	Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385
405416007501	SBF-like CPA transporter family (DUF4137); Region: DUF4137; pfam13593
405416007502	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
405416007503	Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233
405416007504	dimer interface [polypeptide binding]; other site
405416007505	active site
405416007506	metal binding site [ion binding]; metal-binding site
405416007507	glutathione binding site [chemical binding]; other site
405416007508	muropeptide transporter; Validated; Region: ampG; cl17669
405416007509	muropeptide transporter; Validated; Region: ampG; cl17669
405416007510	muropeptide transporter; Validated; Region: ampG; cl17669
405416007511	AAA domain; Region: AAA_32; pfam13654
405416007512	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cl00148
405416007513	primary dimer interface [polypeptide binding]; other site
405416007514	lon-related putative ATP-dependent protease; Region: lon_rel; TIGR00764
405416007515	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
405416007516	Transcriptional regulator [Transcription]; Region: LysR; COG0583
405416007517	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
405416007518	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
405416007519	putative effector binding pocket; other site
405416007520	dimerization interface [polypeptide binding]; other site
405416007521	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
405416007522	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
405416007523	Peptidase family M23; Region: Peptidase_M23; pfam01551
405416007524	5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346
405416007525	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
405416007526	D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686
405416007527	Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936
405416007528	Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663
405416007529	Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645
405416007530	trimer interface [polypeptide binding]; other site
405416007531	putative metal binding site [ion binding]; other site
405416007532	Contains a crystal structure of the Nudix hydrolase from Nitrosomonas europaea, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_2; cd03675
405416007533	nudix motif; other site
405416007534	Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482
405416007535	tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998
405416007536	putative lysogenization regulator; Reviewed; Region: PRK00218
405416007537	adenylosuccinate lyase; Provisional; Region: PRK09285
405416007538	PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598
405416007539	tetramer interface [polypeptide binding]; other site
405416007540	active site
405416007541	Predicted membrane protein (DUF2238); Region: DUF2238; pfam09997
405416007542	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
405416007543	signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706
405416007544	Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023
405416007545	tandem repeat interface [polypeptide binding]; other site
405416007546	oligomer interface [polypeptide binding]; other site
405416007547	active site residues [active]
405416007548	phosphate transporter ATP-binding protein; Provisional; Region: PRK14235
405416007549	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
405416007550	Walker A/P-loop; other site
405416007551	ATP binding site [chemical binding]; other site
405416007552	Q-loop/lid; other site
405416007553	ABC transporter signature motif; other site
405416007554	Walker B; other site
405416007555	D-loop; other site
405416007556	H-loop/switch region; other site
405416007557	Domain of unknown function (DUF3333); Region: DUF3333; pfam11812
405416007558	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581
405416007559	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
405416007560	dimer interface [polypeptide binding]; other site
405416007561	conserved gate region; other site
405416007562	putative PBP binding loops; other site
405416007563	ABC-ATPase subunit interface; other site
405416007564	Phosphate ATP-binding cassette transporter; Region: DUF3708; pfam12501
405416007565	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573
405416007566	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
405416007567	dimer interface [polypeptide binding]; other site
405416007568	conserved gate region; other site
405416007569	putative PBP binding loops; other site
405416007570	ABC-ATPase subunit interface; other site
405416007571	ABC-type phosphate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PstS; COG0226
405416007572	aromatic amino acid transporter; Provisional; Region: PRK10238
405416007573	Pyruvate decarboxylase and related thiamine pyrophosphate-requiring enzymes [Carbohydrate transport and metabolism / Coenzyme metabolism / General function prediction only]; Region: COG3961
405416007574	Pyrimidine (PYR) binding domain of pyruvate decarboxylase (PDC), indolepyruvate decarboxylase (IPDC) and related proteins; Region: TPP_PYR_PDC_IPDC_like; cd07038
405416007575	dimer interface [polypeptide binding]; other site
405416007576	PYR/PP interface [polypeptide binding]; other site
405416007577	TPP binding site [chemical binding]; other site
405416007578	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
405416007579	Thiamine pyrophosphate (TPP) family, PDC_IPDC subfamily, TPP-binding module; composed of proteins similar to pyruvate decarboxylase (PDC) and indolepyruvate decarboxylase (IPDC). PDC, a key enzyme in alcoholic fermentation, catalyzes the conversion of...; Region: TPP_PDC_IPDC; cd02005
405416007580	TPP-binding site [chemical binding]; other site
405416007581	dimer interface [polypeptide binding]; other site
405416007582	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
405416007583	AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404
405416007584	AsnC family; Region: AsnC_trans_reg; pfam01037
405416007585	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
405416007586	Streptomyces aureofaciens putative aldehyde dehydrogenase AldA (AAD23400)-like; Region: ALDH_AldA-AAD23400; cd07106
405416007587	NAD(P) binding site [chemical binding]; other site
405416007588	catalytic residues [active]
405416007589	DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450
405416007590	pyridoxal 5'-phosphate binding site [chemical binding]; other site
405416007591	catalytic residue [active]
405416007592	diaminobutyrate--2-oxoglutarate aminotransferase; Provisional; Region: PRK06931
405416007593	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
405416007594	inhibitor-cofactor binding pocket; inhibition site
405416007595	pyridoxal 5'-phosphate binding site [chemical binding]; other site
405416007596	catalytic residue [active]
405416007597	Protein of unknown function (DUF541); Region: SIMPL; cl01077
405416007598	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
405416007599	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
405416007600	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
405416007601	CoenzymeA binding site [chemical binding]; other site
405416007602	subunit interaction site [polypeptide binding]; other site
405416007603	PHB binding site; other site
405416007604	Fatty acid desaturase; Region: FA_desaturase; pfam00487
405416007605	The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506
405416007606	putative di-iron ligands [ion binding]; other site
405416007607	Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_2; cd06216
405416007608	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
405416007609	FAD binding pocket [chemical binding]; other site
405416007610	FAD binding motif [chemical binding]; other site
405416007611	phosphate binding motif [ion binding]; other site
405416007612	beta-alpha-beta structure motif; other site
405416007613	NAD binding pocket [chemical binding]; other site
405416007614	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
405416007615	catalytic loop [active]
405416007616	iron binding site [ion binding]; other site
405416007617	DNA-binding transcriptional repressor FabR; Provisional; Region: PRK11202
405416007618	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
405416007619	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465
405416007620	ATP-dependent helicase HepA; Validated; Region: PRK04914
405416007621	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
405416007622	ATP binding site [chemical binding]; other site
405416007623	putative Mg++ binding site [ion binding]; other site
405416007624	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
405416007625	nucleotide binding region [chemical binding]; other site
405416007626	ATP-binding site [chemical binding]; other site
405416007627	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
405416007628	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
405416007629	active site
405416007630	Phosphopantetheine attachment site; Region: PP-binding; cl09936
405416007631	glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062
405416007632	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
405416007633	inhibitor-cofactor binding pocket; inhibition site
405416007634	pyridoxal 5'-phosphate binding site [chemical binding]; other site
405416007635	catalytic residue [active]
405416007636	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
405416007637	thiamine phosphate binding site [chemical binding]; other site
405416007638	active site
405416007639	pyrophosphate binding site [ion binding]; other site
405416007640	Protein of unknown function (DUF962); Region: DUF962; pfam06127
405416007641	Uncharacterized subgroup of the CYTH-like superfamily having an associated CHAD domain; Region: CYTH-like_Pase_CHAD; cd07756
405416007642	putative active site [active]
405416007643	putative metal binding residues [ion binding]; other site
405416007644	signature motif; other site
405416007645	putative triphosphate binding site [ion binding]; other site
405416007646	The CHAD domain is an alpha-helical domain functionally associated with some members of the adenylate cyclase family; Region: CHAD; smart00880
405416007647	The CHAD domain is an alpha-helical domain functionally associated with some members of the adenylate cyclase family; Region: CHAD; smart00880
405416007648	Protein of unknown function (DUF3144); Region: DUF3144; pfam11342
405416007649	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
405416007650	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
405416007651	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
405416007652	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
405416007653	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
405416007654	Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384
405416007655	Predicted Na+/dicarboxylate symporter [General function prediction only]; Region: COG1823
405416007656	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
405416007657	Transcriptional regulator [Transcription]; Region: LysR; COG0583
405416007658	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
405416007659	The C-terminal substrate binding domain of LysR-type transcriptional regulators, YofA and SoxR, contains the type 2 periplasmic binding fold; Region: PBP2_YofA_SoxR_like; cd08442
405416007660	putative dimerization interface [polypeptide binding]; other site
405416007661	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
405416007662	Major Facilitator Superfamily; Region: MFS_1; pfam07690
405416007663	putative substrate translocation pore; other site
405416007664	isocitrate dehydrogenase; Validated; Region: PRK06451
405416007665	isocitrate dehydrogenase; Reviewed; Region: PRK07006
405416007666	Pseudouridine synthase, Escherichia coli RluE; Region: PseudoU_synth_RluE; cd02566
405416007667	pseudouridine synthase; Region: TIGR00093
405416007668	probable active site [active]
405416007669	Monomeric isocitrate dehydrogenase [Energy production and conversion]; Region: Icd; COG2838
405416007670	Monomeric isocitrate dehydrogenase; Region: IDH; cl15383
405416007671	Predicted protease with the C-terminal PDZ domain [General function prediction only]; Region: COG3975
405416007672	M61 glycyl aminopeptidase; Region: Peptidase_M61; pfam05299
405416007673	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
405416007674	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
405416007675	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768
405416007676	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
405416007677	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
405416007678	FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095
405416007679	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
405416007680	Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415
405416007681	DNA photolyase; Region: DNA_photolyase; pfam00875
405416007682	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
405416007683	CESA_like is  the cellulose synthase superfamily; Region: CESA_like; cd06423
405416007684	DXD motif; other site
405416007685	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
405416007686	UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381
405416007687	Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase  family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786
405416007688	active site
405416007689	homodimer interface [polypeptide binding]; other site
405416007690	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
405416007691	TPR motif; other site
405416007692	binding surface
405416007693	Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_1; cd02432
405416007694	Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070
405416007695	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
405416007696	FMN binding site [chemical binding]; other site
405416007697	substrate binding site [chemical binding]; other site
405416007698	putative catalytic residue [active]
405416007699	putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737
405416007700	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
405416007701	FMN binding site [chemical binding]; other site
405416007702	active site
405416007703	catalytic residues [active]
405416007704	substrate binding site [chemical binding]; other site
405416007705	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
405416007706	active site
405416007707	DNA binding site [nucleotide binding]
405416007708	Int/Topo IB signature motif; other site
405416007709	Glycosyl hydrolase 108; Region: Glyco_hydro_108; pfam05838
405416007710	Predicted Peptidoglycan domain; Region: PG_binding_3; pfam09374
405416007711	Lysis protein S; Region: Lysis_S; pfam04971
405416007712	Phage-related protein, tail component [Function unknown]; Region: COG4733
405416007713	Putative phage tail protein; Region: Phage-tail_3; pfam13550
405416007714	Phage-related protein, tail component [Function unknown]; Region: COG4723
405416007715	Phage-related protein, tail component [Function unknown]; Region: COG4723
405416007716	Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding) found in proteins also containing NlpC/P60 domains; Region: MPN_NLPC_P60; cd08073
405416007717	MPN+ (JAMM) motif; other site
405416007718	Zinc-binding site [ion binding]; other site
405416007719	NlpC/P60 family; Region: NLPC_P60; cl17555
405416007720	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
405416007721	Phage minor tail protein L; Region: Phage_tail_L; cl01908
405416007722	Phage minor tail protein; Region: Phage_min_tail; cl01940
405416007723	Phage-related minor tail protein [Function unknown]; Region: COG5281
405416007724	tape measure domain; Region: tape_meas_nterm; TIGR02675
405416007725	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
405416007726	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
405416007727	N-acetyl-D-glucosamine binding site [chemical binding]; other site
405416007728	catalytic residue [active]
405416007729	Predicted nuclease of the RNAse H fold, HicB family [General    function prediction only]; Region: COG1598
405416007730	YcfA-like protein; Region: YcfA; pfam07927
405416007731	Putative stress-responsive nuclear envelope protein; Region: Ish1; pfam10281
405416007732	Phage protein (N4 Gp49/phage Sf6 gene 66) family; Region: Phage_gp49_66; pfam13876
405416007733	Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072
405416007734	Domain of unknown function (DUF4055); Region: DUF4055; pfam13264
405416007735	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5410
405416007736	Terminase-like family; Region: Terminase_6; pfam03237
405416007737	Phage-related terminase [General function prediction only]; Region: COG5362; cl02216
405416007738	Uncharacterized conserved protein (DUF2280); Region: DUF2280; pfam10045
405416007739	Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dam; COG0338
405416007740	membrane glycoprotein; Provisional; Region: PHA03332
405416007741	Protein of unknown function (DUF1064); Region: DUF1064; pfam06356
405416007742	HNH nucleases; Region: HNHc; smart00507
405416007743	active site
405416007744	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
405416007745	Active Sites [active]
405416007746	Bacteriophage replication protein O; Region: Phage_rep_O; cl04545
405416007747	Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which  binds to Adenosine nucleotide; Region: AANH_like; cl00292
405416007748	Ligand Binding Site [chemical binding]; other site
405416007749	Predicted transcriptional regulator [Transcription]; Region: COG2932
405416007750	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
405416007751	Catalytic site [active]
405416007752	ERF superfamily; Region: ERF; pfam04404
405416007753	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
405416007754	active site
405416007755	catalytic site [active]
405416007756	substrate binding site [chemical binding]; other site
405416007757	Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420
405416007758	Pyocin activator protein PrtN; Region: PyocinActivator; pfam11112
405416007759	Protein of unknown function (DUF1615); Region: DUF1615; pfam07759
405416007760	Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560
405416007761	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
405416007762	gamma-glutamyl kinase; Provisional; Region: PRK05429
405416007763	AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242
405416007764	nucleotide binding site [chemical binding]; other site
405416007765	homotetrameric interface [polypeptide binding]; other site
405416007766	putative phosphate binding site [ion binding]; other site
405416007767	putative allosteric binding site; other site
405416007768	PUA domain; Region: PUA; pfam01472
405416007769	GTPase CgtA; Reviewed; Region: obgE; PRK12298
405416007770	GTP1/OBG; Region: GTP1_OBG; pfam01018
405416007771	Obg GTPase; Region: Obg; cd01898
405416007772	G1 box; other site
405416007773	GTP/Mg2+ binding site [chemical binding]; other site
405416007774	Switch I region; other site
405416007775	G2 box; other site
405416007776	G3 box; other site
405416007777	Switch II region; other site
405416007778	G4 box; other site
405416007779	G5 box; other site
405416007780	glyceraldehyde-3-phosphate dehydrogenase; Reviewed; Region: PRK08289
405416007781	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846
405416007782	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
405416007783	Predicted permeases [General function prediction only]; Region: RarD; COG2962
405416007784	Bacterial lipocalin [Cell envelope biogenesis, outer membrane]; Region: Blc; COG3040
405416007785	Lipocalin-like domain; Region: Lipocalin_2; pfam08212
405416007786	excinuclease ABC subunit B; Provisional; Region: PRK05298
405416007787	Myosin and Kinesin motor domain. These ATPases belong to the P-loop NTPase family and provide the driving force in myosin and kinesin mediated processes; Region: Motor_domain; cl00286
405416007788	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
405416007789	ATP-binding site [chemical binding]; other site
405416007790	ATP binding site [chemical binding]; other site
405416007791	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
405416007792	nucleotide binding region [chemical binding]; other site
405416007793	ATP-binding site [chemical binding]; other site
405416007794	Ultra-violet resistance protein B; Region: UvrB; pfam12344
405416007795	UvrB/uvrC motif; Region: UVR; pfam02151
405416007796	hypothetical protein; Region: PHA00684
405416007797	PAS domain; Region: PAS_9; pfam13426
405416007798	PAS domain; Region: PAS_9; pfam13426
405416007799	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
405416007800	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
405416007801	metal binding site [ion binding]; metal-binding site
405416007802	active site
405416007803	I-site; other site
405416007804	aspartate aminotransferase; Provisional; Region: PRK05764
405416007805	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
405416007806	pyridoxal 5'-phosphate binding site [chemical binding]; other site
405416007807	homodimer interface [polypeptide binding]; other site
405416007808	catalytic residue [active]
405416007809	Uncharacterized conserved protein [Function unknown]; Region: COG3791
405416007810	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
405416007811	CoenzymeA binding site [chemical binding]; other site
405416007812	subunit interaction site [polypeptide binding]; other site
405416007813	PHB binding site; other site
405416007814	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
405416007815	malonic semialdehyde reductase; Provisional; Region: PRK10538
405416007816	NAD(P) binding site [chemical binding]; other site
405416007817	active site
405416007818	MiaE tRNA-modifying nonheme diiron monooxygenase, ferritin-like diiron-binding domain; Region: MiaE; cd07910
405416007819	active site
405416007820	dinuclear metal binding site [ion binding]; other site
405416007821	dimerization interface [polypeptide binding]; other site
405416007822	Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003
405416007823	active site
405416007824	hydrophilic channel; other site
405416007825	dimerization interface [polypeptide binding]; other site
405416007826	catalytic residues [active]
405416007827	active site lid [active]
405416007828	DNA repair protein RecO; Reviewed; Region: recO; PRK00085
405416007829	Recombination protein O N terminal; Region: RecO_N; pfam11967
405416007830	Recombination protein O C terminal; Region: RecO_C; pfam02565
405416007831	GTPase Era; Reviewed; Region: era; PRK00089
405416007832	E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163
405416007833	G1 box; other site
405416007834	GTP/Mg2+ binding site [chemical binding]; other site
405416007835	Switch I region; other site
405416007836	G2 box; other site
405416007837	Switch II region; other site
405416007838	G3 box; other site
405416007839	G4 box; other site
405416007840	G5 box; other site
405416007841	KH domain; Region: KH_2; pfam07650
405416007842	ribonuclease III; Reviewed; Region: rnc; PRK00102
405416007843	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
405416007844	dimerization interface [polypeptide binding]; other site
405416007845	active site
405416007846	metal binding site [ion binding]; metal-binding site
405416007847	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048
405416007848	dsRNA binding site [nucleotide binding]; other site
405416007849	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
405416007850	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
405416007851	Catalytic site [active]
405416007852	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
405416007853	GTP-binding protein LepA; Provisional; Region: PRK05433
405416007854	LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890
405416007855	G1 box; other site
405416007856	putative GEF interaction site [polypeptide binding]; other site
405416007857	GTP/Mg2+ binding site [chemical binding]; other site
405416007858	Switch I region; other site
405416007859	G2 box; other site
405416007860	G3 box; other site
405416007861	Switch II region; other site
405416007862	G4 box; other site
405416007863	G5 box; other site
405416007864	lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699
405416007865	lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane.   LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709
405416007866	GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421
405416007867	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
405416007868	active site
405416007869	periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037
405416007870	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
405416007871	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
405416007872	protein binding site [polypeptide binding]; other site
405416007873	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
405416007874	protein binding site [polypeptide binding]; other site
405416007875	L-aspartate oxidase; Provisional; Region: PRK09077
405416007876	L-aspartate oxidase; Provisional; Region: PRK06175
405416007877	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
405416007878	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
405416007879	CoenzymeA binding site [chemical binding]; other site
405416007880	subunit interaction site [polypeptide binding]; other site
405416007881	PHB binding site; other site
405416007882	Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672
405416007883	thymidylate kinase; Validated; Region: tmk; PRK00698
405416007884	TMP-binding site; other site
405416007885	ATP-binding site [chemical binding]; other site
405416007886	YceG-like family; Region: YceG; pfam02618
405416007887	proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010
405416007888	dimerization interface [polypeptide binding]; other site
405416007889	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
405416007890	ADCL_like: 4-Amino-4-deoxychorismate lyase:  is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate.  Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559
405416007891	pyridoxal 5'-phosphate binding site [chemical binding]; other site
405416007892	catalytic residue [active]
405416007893	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
405416007894	substrate binding pocket [chemical binding]; other site
405416007895	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
405416007896	membrane-bound complex binding site; other site
405416007897	hinge residues; other site
405416007898	Serine hydrolase; Region: Ser_hydrolase; pfam06821
405416007899	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
405416007900	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
405416007901	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
405416007902	dimer interface [polypeptide binding]; other site
405416007903	conserved gate region; other site
405416007904	putative PBP binding loops; other site
405416007905	ABC-ATPase subunit interface; other site
405416007906	sulfate transport protein; Provisional; Region: cysT; CHL00187
405416007907	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
405416007908	dimer interface [polypeptide binding]; other site
405416007909	conserved gate region; other site
405416007910	putative PBP binding loops; other site
405416007911	ABC-ATPase subunit interface; other site
405416007912	ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118
405416007913	ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296
405416007914	Walker A/P-loop; other site
405416007915	ATP binding site [chemical binding]; other site
405416007916	Q-loop/lid; other site
405416007917	ABC transporter signature motif; other site
405416007918	Walker B; other site
405416007919	D-loop; other site
405416007920	H-loop/switch region; other site
405416007921	TOBE-like domain; Region: TOBE_3; pfam12857
405416007922	transcriptional regulator CysB-like protein; Reviewed; Region: PRK12683
405416007923	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
405416007924	The C-terminal substrate domain of LysR-type transcriptional regulators CysB-like contains type 2 periplasmic binding fold; Region: PBP2_CysB_like; cd08413
405416007925	substrate binding site [chemical binding]; other site
405416007926	dimerization interface [polypeptide binding]; other site
405416007927	2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830
405416007928	2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350
405416007929	active site
405416007930	substrate binding site [chemical binding]; other site
405416007931	trimer interface [polypeptide binding]; other site
405416007932	CoA binding site [chemical binding]; other site
405416007933	putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE, gammaproteobacterial type; Region: rSAM_QueE_gams; TIGR04349
405416007934	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
405416007935	FeS/SAM binding site; other site
405416007936	ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995
405416007937	Ligand Binding Site [chemical binding]; other site
405416007938	Predicted ATPases of PP-loop superfamily [General function prediction only]; Region: COG2102
405416007939	This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily  includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which  binds to Adenosine group.  This subfamily; Region: Alpha_ANH_like_IV; cd01994
405416007940	Ligand Binding Site [chemical binding]; other site
405416007941	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
405416007942	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
405416007943	catalytic triad [active]
405416007944	Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340
405416007945	SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379
405416007946	nicotinamide-nucleotide adenylyltransferase; Provisional; Region: PRK13793
405416007947	active site
405416007948	nucleotide binding site [chemical binding]; other site
405416007949	HIGH motif; other site
405416007950	KMSKS motif; other site
405416007951	enoyl-CoA hydratase; Provisional; Region: PRK06688
405416007952	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
405416007953	substrate binding site [chemical binding]; other site
405416007954	oxyanion hole (OAH) forming residues; other site
405416007955	trimer interface [polypeptide binding]; other site
405416007956	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323
405416007957	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
405416007958	putative substrate translocation pore; other site
405416007959	phosphoribosylformylglycinamidine synthase; Provisional; Region: PRK05297
405416007960	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203
405416007961	dimerization interface [polypeptide binding]; other site
405416007962	ATP binding site [chemical binding]; other site
405416007963	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204
405416007964	dimerization interface [polypeptide binding]; other site
405416007965	ATP binding site [chemical binding]; other site
405416007966	Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740
405416007967	putative active site [active]
405416007968	catalytic triad [active]
405416007969	deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01096
405416007970	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
405416007971	Zn2+ binding site [ion binding]; other site
405416007972	Mg2+ binding site [ion binding]; other site
405416007973	Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116
405416007974	RuvA N terminal domain; Region: RuvA_N; pfam01330
405416007975	RuvA, C-terminal domain; Region: RuvA_C; pfam07499
405416007976	Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080
405416007977	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078
405416007978	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
405416007979	Walker A motif; other site
405416007980	ATP binding site [chemical binding]; other site
405416007981	Walker B motif; other site
405416007982	arginine finger; other site
405416007983	Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491
405416007984	M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like2; cd05667
405416007985	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
405416007986	metal binding site [ion binding]; metal-binding site
405416007987	putative dimer interface [polypeptide binding]; other site
405416007988	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
405416007989	active site
405416007990	TolQ protein; Region: tolQ; TIGR02796
405416007991	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
405416007992	TolR protein; Region: tolR; TIGR02801
405416007993	TolA protein; Region: tolA_full; TIGR02794
405416007994	TonB C terminal; Region: TonB_2; pfam13103
405416007995	translocation protein TolB; Provisional; Region: tolB; PRK04922
405416007996	TolB amino-terminal domain; Region: TolB_N; pfam04052
405416007997	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
405416007998	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
405416007999	putative outer membrane lipoprotein; Provisional; Region: PRK09967
405416008000	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
405416008001	ligand binding site [chemical binding]; other site
405416008002	fructose-1,6-bisphosphatase family protein; Region: PLN02628
405416008003	Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate  into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354
405416008004	AMP binding site [chemical binding]; other site
405416008005	metal binding site [ion binding]; metal-binding site
405416008006	active site
405416008007	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
405416008008	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
405416008009	RNA polymerase factor sigma-70; Validated; Region: PRK09047
405416008010	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
405416008011	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
405416008012	DNA binding residues [nucleotide binding]
405416008013	Protein of unknown function (DUF3106); Region: DUF3106; pfam11304
405416008014	Acinetobacter rhombotarget A; Region: GlyGly_RbtA; TIGR04212
405416008015	CSLREA domain; Region: CSLREA_Nterm; TIGR04214
405416008016	Acinetobacter rhombotarget A; Region: GlyGly_RbtA; TIGR04212
405416008017	CSLREA domain; Region: CSLREA_Nterm; TIGR04214
405416008018	ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593
405416008019	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
405416008020	Walker A motif; other site
405416008021	ATP binding site [chemical binding]; other site
405416008022	Walker B motif; other site
405416008023	arginine finger; other site
405416008024	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
405416008025	Domain of unknown function DUF20; Region: UPF0118; pfam01594
405416008026	phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385
405416008027	PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196
405416008028	dimerization interface [polypeptide binding]; other site
405416008029	putative ATP binding site [chemical binding]; other site
405416008030	phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647
405416008031	Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645
405416008032	active site
405416008033	substrate binding site [chemical binding]; other site
405416008034	cosubstrate binding site; other site
405416008035	catalytic site [active]
405416008036	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
405416008037	Periplasmic serine proteases (ClpP class) [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: SppA; COG0616
405416008038	Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023
405416008039	tandem repeat interface [polypeptide binding]; other site
405416008040	oligomer interface [polypeptide binding]; other site
405416008041	active site residues [active]
405416008042	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
405416008043	putative acyl-acceptor binding pocket; other site
405416008044	Domain of unknown function (DUF4131); Region: DUF4131; pfam13567
405416008045	Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658
405416008046	Competence protein; Region: Competence; pfam03772
405416008047	Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333
405416008048	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
405416008049	lipoprotein releasing system, ATP-binding protein; Region: LolD_lipo_ex; TIGR02211
405416008050	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
405416008051	Walker A/P-loop; other site
405416008052	ATP binding site [chemical binding]; other site
405416008053	Q-loop/lid; other site
405416008054	ABC transporter signature motif; other site
405416008055	Walker B; other site
405416008056	D-loop; other site
405416008057	H-loop/switch region; other site
405416008058	lipoprotein releasing system, transmembrane protein, LolC/E family; Region: lolCE; TIGR02212
405416008059	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
405416008060	FtsX-like permease family; Region: FtsX; pfam02687
405416008061	putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272
405416008062	EamA-like transporter family; Region: EamA; pfam00892
405416008063	Uncharacterized BCR, YaiI/YqxD family COG1671; Region: DUF188; pfam02639
405416008064	Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT).  PSAT is active as...; Region: PSAT_like; cd00611
405416008065	homodimer interface [polypeptide binding]; other site
405416008066	substrate-cofactor binding pocket; other site
405416008067	pyridoxal 5'-phosphate binding site [chemical binding]; other site
405416008068	catalytic residue [active]
405416008069	Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538
405416008070	Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566
405416008071	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
405416008072	HlyD family secretion protein; Region: HlyD_3; pfam13437
405416008073	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
405416008074	ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698
405416008075	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
405416008076	uncharacterized YdjC-like family proteins from bacteria; Region: YdjC_like_3; cd10807
405416008077	putative active site [active]
405416008078	YdjC motif; other site
405416008079	Mg binding site [ion binding]; other site
405416008080	putative homodimer interface [polypeptide binding]; other site
405416008081	undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714
405416008082	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
405416008083	Ligand binding site; other site
405416008084	Putative Catalytic site; other site
405416008085	DXD motif; other site
405416008086	GtrA-like protein; Region: GtrA; pfam04138
405416008087	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807
405416008088	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364
405416008089	DNA gyrase subunit A; Validated; Region: PRK05560
405416008090	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
405416008091	CAP-like domain; other site
405416008092	active site
405416008093	primary dimer interface [polypeptide binding]; other site
405416008094	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
405416008095	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
405416008096	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
405416008097	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
405416008098	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
405416008099	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
405416008100	electron transfer flavoprotein subunit alpha; Provisional; Region: PLN00022
405416008101	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715
405416008102	Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766
405416008103	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714
405416008104	Ligand binding site [chemical binding]; other site
405416008105	Electron transfer flavoprotein domain; Region: ETF; pfam01012
405416008106	site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236
405416008107	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
405416008108	active site
405416008109	DNA binding site [nucleotide binding]
405416008110	Int/Topo IB signature motif; other site
405416008111	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
405416008112	diaminopimelate epimerase; Provisional; Region: dapF; PRK00450
405416008113	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
405416008114	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
405416008115	diaminopimelate decarboxylase; Region: lysA; TIGR01048
405416008116	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828
405416008117	active site
405416008118	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
405416008119	substrate binding site [chemical binding]; other site
405416008120	catalytic residues [active]
405416008121	dimer interface [polypeptide binding]; other site
405416008122	D-alanine/D-serine/glycine permease; Provisional; Region: PRK11049
405416008123	DNA repair protein RadA; Provisional; Region: PRK11823
405416008124	Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121
405416008125	Walker A motif/ATP binding site; other site
405416008126	ATP binding site [chemical binding]; other site
405416008127	Walker B motif; other site
405416008128	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
405416008129	Tim44 is an essential component of the machinery that mediates the translocation of nuclear-encoded proteins across the mitochondrial inner membrane; Region: Tim44; smart00978
405416008130	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
405416008131	EF-P lysine aminoacylase GenX; Region: genX; TIGR00462
405416008132	motif 1; other site
405416008133	dimer interface [polypeptide binding]; other site
405416008134	active site
405416008135	motif 2; other site
405416008136	motif 3; other site
405416008137	erythronate-4-phosphate dehydrogenase; Validated; Region: PRK00257
405416008138	D-Erythronate-4-Phosphate Dehydrogenase NAD-binding and catalytic domains; Region: ErythrP_dh; cd12158
405416008139	ligand binding site [chemical binding]; other site
405416008140	NAD binding site [chemical binding]; other site
405416008141	catalytic site [active]
405416008142	homodimer interface [polypeptide binding]; other site
405416008143	Protein of unknown function (DUF1232); Region: DUF1232; cl01318
405416008144	formate dehydrogenase accessory protein; Reviewed; Region: PRK00724
405416008145	The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767
405416008146	putative molybdopterin cofactor binding site [chemical binding]; other site
405416008147	The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787
405416008148	putative molybdopterin cofactor binding site; other site
405416008149	Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929
405416008150	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
405416008151	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
405416008152	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
405416008153	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
405416008154	NAD(P) binding site [chemical binding]; other site
405416008155	active site
405416008156	Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137
405416008157	dimer interface [polypeptide binding]; other site
405416008158	FMN binding site [chemical binding]; other site
405416008159	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
405416008160	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
405416008161	Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687
405416008162	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
405416008163	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
405416008164	The adenylation (A) domain of siderophore-synthesizing nonribosomal peptide synthetases (NRPS); Region: A_NRPS_SidN3_like; cd05918
405416008165	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
405416008166	acyl-activating enzyme (AAE) consensus motif; other site
405416008167	AMP binding site [chemical binding]; other site
405416008168	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
405416008169	non-ribosomal peptide synthetase terminal domain of unknown function; Region: NRPS_term_dom; TIGR02353
405416008170	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
405416008171	putative trimer interface [polypeptide binding]; other site
405416008172	putative CoA binding site [chemical binding]; other site
405416008173	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
405416008174	putative CoA binding site [chemical binding]; other site
405416008175	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
405416008176	Calcium/calmodulin dependent protein kinase II Association; Region: CaMKII_AD; cl17504
405416008177	transcription elongation factor GreB; Reviewed; Region: greB; PRK01885
405416008178	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
405416008179	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
405416008180	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
405416008181	N-acetyl-D-glucosamine binding site [chemical binding]; other site
405416008182	catalytic residue [active]
405416008183	SCP-2 sterol transfer family; Region: SCP2; pfam02036
405416008184	tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696
405416008185	This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily  includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which  binds to Adenosine group.  This subfamily; Region: Alpha_ANH_like_II; cd01993
405416008186	Ligand Binding Site [chemical binding]; other site
405416008187	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
405416008188	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
405416008189	N-acetyl-D-glucosamine binding site [chemical binding]; other site
405416008190	catalytic residue [active]
405416008191	heat shock protein HtpX; Provisional; Region: PRK05457
405416008192	Domain of unknown function (DUF4112); Region: DUF4112; pfam13430
405416008193	The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915
405416008194	Protein export membrane protein; Region: SecD_SecF; cl14618
405416008195	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
405416008196	Glycerophosphodiester phosphodiesterase domain of Streptomycin coelicolor (GlpQ1) and similar proteins; Region: GDPD_ScGlpQ1_like; cd08602
405416008197	putative active site [active]
405416008198	catalytic site [active]
405416008199	putative metal binding site [ion binding]; other site
405416008200	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
405416008201	Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818
405416008202	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
405416008203	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
405416008204	ring oligomerisation interface [polypeptide binding]; other site
405416008205	ATP/Mg binding site [chemical binding]; other site
405416008206	stacking interactions; other site
405416008207	hinge regions; other site
405416008208	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
405416008209	oligomerisation interface [polypeptide binding]; other site
405416008210	mobile loop; other site
405416008211	roof hairpin; other site
405416008212	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
405416008213	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
405416008214	Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753
405416008215	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
405416008216	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
405416008217	type I secretion C-terminal target domain (VC_A0849 subclass); Region: T1SS_VCA0849; TIGR03661
405416008218	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
405416008219	Bacillus subtilis YydB and related proteins, metallophosphatase domain; Region: MPP_YydB; cd07400
405416008220	putative active site [active]
405416008221	putative metal binding site [ion binding]; other site
405416008222	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
405416008223	active site
405416008224	metal binding site [ion binding]; metal-binding site
405416008225	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
405416008226	Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597
405416008227	Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819
405416008228	active site
405416008229	substrate-binding site [chemical binding]; other site
405416008230	metal-binding site [ion binding]
405416008231	GTP binding site [chemical binding]; other site
405416008232	glycerol-3-phosphate dehydrogenase; Reviewed; Region: glpD; PRK12266
405416008233	glycerol kinase; Provisional; Region: glpK; PRK00047
405416008234	Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786
405416008235	N- and C-terminal domain interface [polypeptide binding]; other site
405416008236	active site
405416008237	MgATP binding site [chemical binding]; other site
405416008238	catalytic site [active]
405416008239	metal binding site [ion binding]; metal-binding site
405416008240	glycerol binding site [chemical binding]; other site
405416008241	homotetramer interface [polypeptide binding]; other site
405416008242	homodimer interface [polypeptide binding]; other site
405416008243	FBP binding site [chemical binding]; other site
405416008244	protein IIAGlc interface [polypeptide binding]; other site
405416008245	alpha-ketoglutarate transporter; Provisional; Region: PRK10406
405416008246	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
405416008247	putative substrate translocation pore; other site
405416008248	Predicted methyltransferase [General function prediction only]; Region: COG3897
405416008249	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
405416008250	S-adenosylmethionine binding site [chemical binding]; other site
405416008251	bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14192
405416008252	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
405416008253	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
405416008254	homodimer interface [polypeptide binding]; other site
405416008255	NADP binding site [chemical binding]; other site
405416008256	substrate binding site [chemical binding]; other site
405416008257	PhoD-like phosphatase; Region: PhoD; pfam09423
405416008258	Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389
405416008259	putative active site [active]
405416008260	putative metal binding site [ion binding]; other site
405416008261	Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389
405416008262	DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
405416008263	dihydropteroate synthase; Region: DHPS; TIGR01496
405416008264	substrate binding pocket [chemical binding]; other site
405416008265	dimer interface [polypeptide binding]; other site
405416008266	inhibitor binding site; inhibition site
405416008267	FtsH Extracellular; Region: FtsH_ext; pfam06480
405416008268	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
405416008269	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
405416008270	Walker A motif; other site
405416008271	ATP binding site [chemical binding]; other site
405416008272	Walker B motif; other site
405416008273	arginine finger; other site
405416008274	Peptidase family M41; Region: Peptidase_M41; pfam01434
405416008275	FtsJ-like methyltransferase; Region: FtsJ; cl17430
405416008276	23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293
405416008277	Escherichia coli YhbY is associated with pre-50S ribosomal subunits, which implies a function in ribosome assembly; Region: CRS1_YhbY; smart01103
405416008278	Domon-like domain of UDP-N-acetylenolpyruvoylglucosamine reductase; Region: DOMON_murB_like; cd09627
405416008279	putative heme binding site [chemical binding]; other site
405416008280	carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564
405416008281	Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097
405416008282	Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744
405416008283	catalytic site [active]
405416008284	subunit interface [polypeptide binding]; other site
405416008285	carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294
405416008286	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
405416008287	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
405416008288	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
405416008289	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
405416008290	ATP-grasp domain; Region: ATP-grasp_4; cl17255
405416008291	Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424
405416008292	IMP binding site; other site
405416008293	dimer interface [polypeptide binding]; other site
405416008294	interdomain contacts; other site
405416008295	partial ornithine binding site; other site
405416008296	transcription elongation factor GreA; Reviewed; Region: greA; PRK00226
405416008297	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
405416008298	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
405416008299	Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110
405416008300	Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349
405416008301	trimer interface [polypeptide binding]; other site
405416008302	active site
405416008303	substrate binding site [chemical binding]; other site
405416008304	CoA binding site [chemical binding]; other site
405416008305	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
405416008306	Ligand Binding Site [chemical binding]; other site
405416008307	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
405416008308	DNA binding site [nucleotide binding]
405416008309	active site
405416008310	Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064
405416008311	active site
405416008312	CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381
405416008313	putative active site [active]
405416008314	putative metal binding site [ion binding]; other site
405416008315	Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854
405416008316	type 2 lantibiotic biosynthesis protein LanM; Region: lanti_2_LanM; TIGR03897
405416008317	type I secretion C-terminal target domain (VC_A0849 subclass); Region: T1SS_VCA0849; TIGR03661
405416008318	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
405416008319	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
405416008320	tail sheath protein; Provisional; Region: 18; PHA02539
405416008321	NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025
405416008322	Predicted metalloprotease [General function prediction only]; Region: COG2321
405416008323	Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228
405416008324	Protein of unknown function (DUF808); Region: DUF808; pfam05661
405416008325	tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282
405416008326	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
405416008327	active site
405416008328	HIGH motif; other site
405416008329	dimer interface [polypeptide binding]; other site
405416008330	KMSKS motif; other site
405416008331	succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678
405416008332	CoA binding domain; Region: CoA_binding; smart00881
405416008333	CoA-ligase; Region: Ligase_CoA; pfam00549
405416008334	succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696
405416008335	ATP-grasp domain; Region: ATP-grasp_2; pfam08442
405416008336	CoA-ligase; Region: Ligase_CoA; pfam00549
405416008337	dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06467
405416008338	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
405416008339	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
405416008340	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
405416008341	dihydrolipoamide succinyltransferase; Validated; Region: PRK05704
405416008342	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
405416008343	E3 interaction surface; other site
405416008344	lipoyl attachment site [posttranslational modification]; other site
405416008345	e3 binding domain; Region: E3_binding; pfam02817
405416008346	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
405416008347	2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404
405416008348	Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016
405416008349	TPP-binding site [chemical binding]; other site
405416008350	Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779
405416008351	succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950
405416008352	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085
405416008353	succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07057
405416008354	L-aspartate oxidase; Provisional; Region: PRK06175
405416008355	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
405416008356	Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. E. coli SQR, a member of this subfamily, reduces the...; Region: SQR_TypeC_SdhD; cd03494
405416008357	SdhC subunit interface [polypeptide binding]; other site
405416008358	proximal heme binding site [chemical binding]; other site
405416008359	cardiolipin binding site; other site
405416008360	Iron-sulfur protein interface; other site
405416008361	proximal quinone binding site [chemical binding]; other site
405416008362	Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499
405416008363	proximal quinone binding site [chemical binding]; other site
405416008364	SdhD (CybS) interface [polypeptide binding]; other site
405416008365	proximal heme binding site [chemical binding]; other site
405416008366	Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114
405416008367	Citrate synthase [Energy production and conversion]; Region: GltA; COG0372
405416008368	dimer interface [polypeptide binding]; other site
405416008369	active site
405416008370	citrylCoA binding site [chemical binding]; other site
405416008371	NADH binding [chemical binding]; other site
405416008372	cationic pore residues; other site
405416008373	oxalacetate/citrate binding site [chemical binding]; other site
405416008374	coenzyme A binding site [chemical binding]; other site
405416008375	catalytic triad [active]
405416008376	Protein of unknown function (DUF1289); Region: DUF1289; pfam06945
405416008377	Predicted sulfurtransferase [General function prediction only]; Region: COG1054
405416008378	Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518
405416008379	active site residue [active]
405416008380	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
405416008381	Helix-turn-helix domain; Region: HTH_38; pfam13936
405416008382	Homeodomain-like domain; Region: HTH_32; pfam13565
405416008383	Integrase core domain; Region: rve; pfam00665
405416008384	Integrase core domain; Region: rve_3; cl15866
405416008385	Uncharacterized protein family (UPF0149); Region: UPF0149; pfam03695
405416008386	Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979
405416008387	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
405416008388	Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546
405416008389	RNA polymerase sigma factor RpoD, C-terminal domain; Region: RpoD_Cterm; TIGR02393
405416008390	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
405416008391	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
405416008392	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
405416008393	DNA binding residues [nucleotide binding]
405416008394	Protein of unknown function (DUF493); Region: DUF493; pfam04359
405416008395	lipoate-protein ligase B; Provisional; Region: PRK14342
405416008396	Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454
405416008397	Iron-containing alcohol dehydrogenases-like; Region: Fe-ADH5; cd08189
405416008398	putative active site [active]
405416008399	metal binding site [ion binding]; metal-binding site
405416008400	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
405416008401	Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655
405416008402	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
405416008403	Predicted transcriptional regulators [Transcription]; Region: COG1733
405416008404	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
405416008405	Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219
405416008406	siroheme synthase; Provisional; Region: cysG; PRK10637
405416008407	Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241
405416008408	Sirohaem synthase dimerisation region; Region: CysG_dimeriser; pfam10414
405416008409	Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642
405416008410	active site
405416008411	SAM binding site [chemical binding]; other site
405416008412	homodimer interface [polypeptide binding]; other site
405416008413	seryl-tRNA synthetase; Provisional; Region: PRK05431
405416008414	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
405416008415	Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770
405416008416	dimer interface [polypeptide binding]; other site
405416008417	active site
405416008418	motif 1; other site
405416008419	motif 2; other site
405416008420	motif 3; other site
405416008421	Protein of unknown function (DUF3298); Region: DUF3298; pfam11738
405416008422	lipoprotein chaperone; Reviewed; Region: lolA; PRK00031
405416008423	Outer membrane lipoprotein carrier protein LolA; Region: LolA; pfam03548
405416008424	50S ribosomal protein L27; Validated; Region: rpmA; PRK05435
405416008425	50S ribosomal protein L21; Validated; Region: rplU; PRK05573
405416008426	50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278
405416008427	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
405416008428	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
405416008429	substrate binding pocket [chemical binding]; other site
405416008430	chain length determination region; other site
405416008431	substrate-Mg2+ binding site; other site
405416008432	catalytic residues [active]
405416008433	aspartate-rich region 1; other site
405416008434	active site lid residues [active]
405416008435	aspartate-rich region 2; other site
405416008436	Site-specific recombinase; Region: SpecificRecomb; pfam10136
405416008437	PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392
405416008438	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
405416008439	active site
405416008440	multidrug efflux system transporter AcrA; Provisional; Region: PRK15030
405416008441	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
405416008442	HlyD family secretion protein; Region: HlyD_3; pfam13437
405416008443	The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915
405416008444	Protein export membrane protein; Region: SecD_SecF; cl14618
405416008445	Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538
405416008446	Putative heavy-metal-binding; Region: YbjQ_1; cl00426
405416008447	Uncharacterized conserved protein [Function unknown]; Region: COG0393
405416008448	SnoaL-like domain; Region: SnoaL_4; pfam13577
405416008449	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
405416008450	short chain dehydrogenase; Provisional; Region: PRK06181
405416008451	NAD(P) binding site [chemical binding]; other site
405416008452	active site
405416008453	valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729
405416008454	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
405416008455	HIGH motif; other site
405416008456	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
405416008457	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
405416008458	active site
405416008459	KMSKS motif; other site
405416008460	Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962
405416008461	tRNA binding surface [nucleotide binding]; other site
405416008462	anticodon binding site; other site
405416008463	Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458
405416008464	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
405416008465	S-adenosylmethionine binding site [chemical binding]; other site
405416008466	Predicted permeases [General function prediction only]; Region: COG0679
405416008467	Transcriptional regulator [Transcription]; Region: LysR; COG0583
405416008468	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
405416008469	putative DNA binding site [nucleotide binding]; other site
405416008470	putative Zn2+ binding site [ion binding]; other site
405416008471	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
405416008472	dimerization interface [polypeptide binding]; other site
405416008473	Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004
405416008474	PAP2_like_6 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which mainly contains bacterial proteins, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_6; cd03396
405416008475	active site
405416008476	sensor protein QseC; Provisional; Region: PRK10337
405416008477	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
405416008478	dimer interface [polypeptide binding]; other site
405416008479	phosphorylation site [posttranslational modification]
405416008480	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
405416008481	ATP binding site [chemical binding]; other site
405416008482	Mg2+ binding site [ion binding]; other site
405416008483	G-X-G motif; other site
405416008484	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
405416008485	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
405416008486	active site
405416008487	phosphorylation site [posttranslational modification]
405416008488	intermolecular recognition site; other site
405416008489	dimerization interface [polypeptide binding]; other site
405416008490	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
405416008491	DNA binding site [nucleotide binding]
405416008492	putative metal dependent hydrolase; Provisional; Region: PRK11598
405416008493	Domain of unknown function (DUF1705); Region: DUF1705; pfam08019
405416008494	Sulfatase; Region: Sulfatase; pfam00884
405416008495	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
405416008496	muropeptide transporter; Validated; Region: ampG; cl17669
405416008497	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
405416008498	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown ABO13168; Region: LPLAT_ABO13168-like; cd07988
405416008499	putative acyl-acceptor binding pocket; other site
405416008500	hypothetical protein; Provisional; Region: PRK10279
405416008501	Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205
405416008502	nucleophile elbow; other site
405416008503	Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585
405416008504	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
405416008505	Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403
405416008506	Protein of unknown function (DUF419); Region: DUF419; cl15265
405416008507	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
405416008508	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
405416008509	substrate binding pocket [chemical binding]; other site
405416008510	chain length determination region; other site
405416008511	substrate-Mg2+ binding site; other site
405416008512	catalytic residues [active]
405416008513	aspartate-rich region 1; other site
405416008514	active site lid residues [active]
405416008515	aspartate-rich region 2; other site
405416008516	probable AcnD-accessory protein PrpF; Region: prpF; TIGR02334
405416008517	Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113
405416008518	chaperone protein HchA; Provisional; Region: PRK04155
405416008519	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
405416008520	conserved cys residue [active]
405416008521	putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824
405416008522	PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276
405416008523	NAD(P) binding site [chemical binding]; other site
405416008524	AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719
405416008525	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
405416008526	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
405416008527	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
405416008528	undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281
405416008529	Mrr N-terminal domain; Region: Mrr_N; pfam14338
405416008530	PaaX-like protein C-terminal domain; Region: PaaX_C; pfam08223
405416008531	This CD includes the dihydrorhizobitoxine fatty acid desaturase (RtxC) characterized in Bradyrhizobium japonicum USDA110, and other related proteins. Dihydrorhizobitoxine desaturase is reported to be involved in the final step of rhizobitoxine...; Region: Rhizobitoxine-FADS-like; cd03510
405416008532	putative di-iron ligands [ion binding]; other site
405416008533	This CD includes the dihydrorhizobitoxine fatty acid desaturase (RtxC) characterized in Bradyrhizobium japonicum USDA110, and other related proteins. Dihydrorhizobitoxine desaturase is reported to be involved in the final step of rhizobitoxine...; Region: Rhizobitoxine-FADS-like; cd03510
405416008534	Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625
405416008535	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
405416008536	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
405416008537	Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525
405416008538	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
405416008539	Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; cl17479
405416008540	Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; cl17479
405416008541	phosphoserine phosphatase; Provisional; Region: thrH; PRK13582
405416008542	Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560
405416008543	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
405416008544	Active Sites [active]
405416008545	acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946
405416008546	Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007
405416008547	ribonuclease G; Provisional; Region: PRK11712
405416008548	S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453
405416008549	homodimer interface [polypeptide binding]; other site
405416008550	oligonucleotide binding site [chemical binding]; other site
405416008551	Maf-like protein; Region: Maf; pfam02545
405416008552	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
405416008553	active site
405416008554	dimer interface [polypeptide binding]; other site
405416008555	rod shape-determining protein MreD; Region: shape_MreD; TIGR03426
405416008556	rod shape-determining protein MreC; Provisional; Region: PRK13922
405416008557	rod shape-determining protein MreC; Region: MreC; pfam04085
405416008558	rod shape-determining protein MreB; Provisional; Region: PRK13927
405416008559	MreB and similar proteins; Region: MreB_like; cd10225
405416008560	nucleotide binding site [chemical binding]; other site
405416008561	Mg binding site [ion binding]; other site
405416008562	putative protofilament interaction site [polypeptide binding]; other site
405416008563	RodZ interaction site [polypeptide binding]; other site
405416008564	aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034
405416008565	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
405416008566	aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012
405416008567	aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477
405416008568	GatB/GatE catalytic domain; Region: GatB_N; pfam02934
405416008569	GatB domain; Region: GatB_Yqey; smart00845
405416008570	intracellular protease, PfpI family; Region: PfpI; TIGR01382
405416008571	Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_1; cd03169
405416008572	conserved cys residue [active]
405416008573	Protein of unknown function (DUF1176); Region: DUF1176; pfam06674
405416008574	microcin B17 transporter; Reviewed; Region: PRK11098
405416008575	threonine dehydratase; Provisional; Region: PRK07334
405416008576	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
405416008577	tetramer interface [polypeptide binding]; other site
405416008578	pyridoxal 5'-phosphate binding site [chemical binding]; other site
405416008579	catalytic residue [active]
405416008580	C-terminal ACT domain of biodegradative (catabolic) threonine dehydratase II (ThrD-II) and other related ACT domains; Region: ACT_ThrD-II-like; cd04886
405416008581	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752
405416008582	Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205
405416008583	active site
405416008584	nucleophile elbow; other site
405416008585	Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115
405416008586	Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548
405416008587	Nitroreductase family. Members of this family utilize FMN as a cofactor and catalyze reduction of a variety of nitroaromatic compounds, including nitrofurans, nitrobenzens, nitrophenol, nitrobenzoate and quinones by using either NADH or NADPH as a source...; Region: Nitroreductase; cd02136
405416008588	putative FMN binding site [chemical binding]; other site
405416008589	bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102
405416008590	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
405416008591	putative substrate translocation pore; other site
405416008592	TIGR01666 family membrane protein; Region: YCCS
405416008593	FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805
405416008594	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
405416008595	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
405416008596	YcxB-like protein; Region: YcxB; pfam14317
405416008597	Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182
405416008598	PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172
405416008599	PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703
405416008600	Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; Region: CysJ; COG0369
405416008601	Flavodoxin; Region: Flavodoxin_1; pfam00258
405416008602	Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR_like1; cd06200
405416008603	FAD binding pocket [chemical binding]; other site
405416008604	FAD binding motif [chemical binding]; other site
405416008605	catalytic residues [active]
405416008606	NAD binding pocket [chemical binding]; other site
405416008607	phosphate binding motif [ion binding]; other site
405416008608	beta-alpha-beta structure motif; other site
405416008609	Uncharacterized conserved protein [Function unknown]; Region: COG1434
405416008610	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
405416008611	putative active site [active]
405416008612	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
405416008613	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
405416008614	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2832
405416008615	Domain of unknown function (DUF1853); Region: DUF1853; cl01545
405416008616	Predicted small secreted protein [Function unknown]; Region: COG5510
405416008617	succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009
405416008618	M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891
405416008619	metal binding site [ion binding]; metal-binding site
405416008620	dimer interface [polypeptide binding]; other site
405416008621	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
405416008622	putative binding surface; other site
405416008623	active site
405416008624	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
405416008625	putative binding surface; other site
405416008626	active site
405416008627	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
405416008628	putative binding surface; other site
405416008629	active site
405416008630	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
405416008631	putative binding surface; other site
405416008632	active site
405416008633	Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895
405416008634	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
405416008635	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
405416008636	ATP binding site [chemical binding]; other site
405416008637	Mg2+ binding site [ion binding]; other site
405416008638	G-X-G motif; other site
405416008639	CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731
405416008640	Response regulator receiver domain; Region: Response_reg; pfam00072
405416008641	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
405416008642	active site
405416008643	phosphorylation site [posttranslational modification]
405416008644	intermolecular recognition site; other site
405416008645	dimerization interface [polypeptide binding]; other site
405416008646	Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675
405416008647	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
405416008648	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
405416008649	dimer interface [polypeptide binding]; other site
405416008650	putative CheW interface [polypeptide binding]; other site
405416008651	Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835
405416008652	Response regulator receiver domain; Region: Response_reg; pfam00072
405416008653	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
405416008654	active site
405416008655	phosphorylation site [posttranslational modification]
405416008656	intermolecular recognition site; other site
405416008657	dimerization interface [polypeptide binding]; other site
405416008658	Response regulator receiver domain; Region: Response_reg; pfam00072
405416008659	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
405416008660	active site
405416008661	phosphorylation site [posttranslational modification]
405416008662	intermolecular recognition site; other site
405416008663	dimerization interface [polypeptide binding]; other site
405416008664	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
405416008665	HlyD family secretion protein; Region: HlyD_3; pfam13437
405416008666	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
405416008667	prolyl-tRNA synthetase; Provisional; Region: PRK09194
405416008668	Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779
405416008669	dimer interface [polypeptide binding]; other site
405416008670	motif 1; other site
405416008671	active site
405416008672	motif 2; other site
405416008673	INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334
405416008674	putative deacylase active site [active]
405416008675	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
405416008676	active site
405416008677	motif 3; other site
405416008678	ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861
405416008679	anticodon binding site; other site
405416008680	Uncharacterized conserved protein [Function unknown]; Region: COG3422
405416008681	Domain of unknown function (DUF1508); Region: DUF1508; pfam07411
405416008682	Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824
405416008683	PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274
405416008684	PhnA protein; Region: PhnA; pfam03831
405416008685	Uncharacterized conserved protein [Function unknown]; Region: COG3189
405416008686	Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_2; cd08895
405416008687	putative hydrophobic ligand binding site [chemical binding]; other site
405416008688	Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354
405416008689	folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317
405416008690	protein disulfide isomerase II DsbC; Provisional; Region: PRK10877
405416008691	DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020
405416008692	dimerization domain [polypeptide binding]; other site
405416008693	dimer interface [polypeptide binding]; other site
405416008694	catalytic residues [active]
405416008695	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
405416008696	Sel1-like repeats; Region: SEL1; smart00671
405416008697	Predicted permeases [General function prediction only]; Region: COG0679
405416008698	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
405416008699	Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis.  Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932
405416008700	active site
405416008701	FMN binding site [chemical binding]; other site
405416008702	substrate binding site [chemical binding]; other site
405416008703	homotetramer interface [polypeptide binding]; other site
405416008704	catalytic residue [active]
405416008705	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
405416008706	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
405416008707	N-terminal plug; other site
405416008708	ligand-binding site [chemical binding]; other site
405416008709	Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540
405416008710	active site
405416008711	DNA binding site [nucleotide binding]
405416008712	formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103
405416008713	N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966
405416008714	DNA binding site [nucleotide binding]
405416008715	catalytic residue [active]
405416008716	H2TH interface [polypeptide binding]; other site
405416008717	putative catalytic residues [active]
405416008718	turnover-facilitating residue; other site
405416008719	intercalation triad [nucleotide binding]; other site
405416008720	8OG recognition residue [nucleotide binding]; other site
405416008721	putative reading head residues; other site
405416008722	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
405416008723	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
405416008724	PPIC-type PPIASE domain; Region: Rotamase_2; cl08278
405416008725	GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661
405416008726	putative active site pocket [active]
405416008727	dimerization interface [polypeptide binding]; other site
405416008728	putative catalytic residue [active]
405416008729	large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13952
405416008730	large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567
405416008731	Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217
405416008732	Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891
405416008733	G1 box; other site
405416008734	putative GEF interaction site [polypeptide binding]; other site
405416008735	GTP/Mg2+ binding site [chemical binding]; other site
405416008736	Switch I region; other site
405416008737	G2 box; other site
405416008738	G3 box; other site
405416008739	Switch II region; other site
405416008740	G4 box; other site
405416008741	G5 box; other site
405416008742	BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu.  BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691
405416008743	BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants.  BipA is a highly...; Region: BipA_TypA_C; cd03710
405416008744	Xanthine/uracil permeases [Nucleotide transport and metabolism]; Region: UraA; COG2233
405416008745	16S ribosomal RNA m2G1207 methyltransferase; Provisional; Region: rsmC; PRK09489
405416008746	Methyltransferase small domain N-terminal; Region: MTS_N; pfam08468
405416008747	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
405416008748	S-adenosylmethionine binding site [chemical binding]; other site
405416008749	lysine transporter; Provisional; Region: PRK10836
405416008750	Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139
405416008751	hypothetical protein; Reviewed; Region: PRK09588
405416008752	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505
405416008753	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
405416008754	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
405416008755	ligand binding site [chemical binding]; other site
405416008756	Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830
405416008757	Type II transport protein GspH; Region: GspH; pfam12019
405416008758	acetyl-CoA acetyltransferase; Provisional; Region: PRK06954
405416008759	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
405416008760	dimer interface [polypeptide binding]; other site
405416008761	active site
405416008762	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
405416008763	Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588
405416008764	dimer interface [polypeptide binding]; other site
405416008765	Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076
405416008766	Bacterial protein of unknown function (DUF934); Region: DUF934; pfam06073
405416008767	Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155
405416008768	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
405416008769	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
405416008770	membrane-bound PQQ-dependent dehydrogenase, glucose/quinate/shikimate family; Region: PQQ_membr_DH; TIGR03074
405416008771	Membrane-bound PQQ-dependent glucose dehydrogenase; Region: PQQ_mGDH; cd10280
405416008772	Trp docking motif [polypeptide binding]; other site
405416008773	putative active site [active]
405416008774	Carbohydrate-selective porin, OprB family; Region: OprB; cl17816
405416008775	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
405416008776	CoA-transferase family III; Region: CoA_transf_3; pfam02515
405416008777	Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625
405416008778	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
405416008779	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
405416008780	acetyl-CoA acetyltransferase; Validated; Region: PRK08242
405416008781	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
405416008782	dimer interface [polypeptide binding]; other site
405416008783	active site
405416008784	multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154
405416008785	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
405416008786	substrate binding site [chemical binding]; other site
405416008787	oxyanion hole (OAH) forming residues; other site
405416008788	trimer interface [polypeptide binding]; other site
405416008789	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
405416008790	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
405416008791	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667
405416008792	Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208
405416008793	active site
405416008794	nucleophile elbow; other site
405416008795	Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; pfam13444
405416008796	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
405416008797	Methyltransferase domain; Region: Methyltransf_31; pfam13847
405416008798	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
405416008799	S-adenosylmethionine binding site [chemical binding]; other site
405416008800	Haemolysin-III related; Region: HlyIII; cl03831
405416008801	channel protein, hemolysin III family; Region: hlyIII; TIGR01065
405416008802	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
405416008803	metabolite-proton symporter; Region: 2A0106; TIGR00883
405416008804	putative substrate translocation pore; other site
405416008805	preprotein translocase subunit SecA; Reviewed; Region: PRK12904
405416008806	SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958
405416008807	SEC-C motif; Region: SEC-C; pfam02810
405416008808	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
405416008809	Peroxiredoxin (PRX) family, 1-cys PRX subfamily; composed of PRXs containing only one conserved cysteine, which serves as the peroxidatic cysteine. They are homodimeric thiol-specific antioxidant (TSA) proteins that confer a protective role in cells by...; Region: PRX_1cys; cd03016
405416008810	dimer interface [polypeptide binding]; other site
405416008811	decamer (pentamer of dimers) interface [polypeptide binding]; other site
405416008812	catalytic triad [active]
405416008813	Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753
405416008814	Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053
405416008815	active site
405416008816	catalytic residues [active]
405416008817	Sporulation related domain; Region: SPOR; cl10051
405416008818	Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285
405416008819	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
405416008820	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
405416008821	acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654
405416008822	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
405416008823	tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200
405416008824	Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724
405416008825	substrate binding site [chemical binding]; other site
405416008826	active site
405416008827	catalytic residues [active]
405416008828	heterodimer interface [polypeptide binding]; other site
405416008829	Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625
405416008830	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
405416008831	Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687
405416008832	Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118
405416008833	Protein of unknown function (DUF2804); Region: DUF2804; pfam10974
405416008834	Domain of Unknown Function (DUF1543); Region: DUF1543; pfam07566
405416008835	tryptophan synthase, beta subunit; Region: trpB; TIGR00263
405416008836	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
405416008837	pyridoxal 5'-phosphate binding site [chemical binding]; other site
405416008838	catalytic residue [active]
405416008839	Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405
405416008840	active site
405416008841	Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206
405416008842	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
405416008843	N-terminal plug; other site
405416008844	ligand-binding site [chemical binding]; other site
405416008845	Cobalamin adenosyltransferase; Region: Cob_adeno_trans; pfam01923
405416008846	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
405416008847	Glycerophosphodiester phosphodiesterase domain as found in prokaryota and eukaryota, and similar proteins; Region: GDPD; cd08556
405416008848	active site
405416008849	catalytic site [active]
405416008850	metal binding site [ion binding]; metal-binding site
405416008851	META domain; Region: META; pfam03724
405416008852	The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505
405416008853	Fatty acid desaturase; Region: FA_desaturase; pfam00487
405416008854	Di-iron ligands [ion binding]; other site
405416008855	Uncharacterized conserved protein [Function unknown]; Region: COG0397
405416008856	hypothetical protein; Validated; Region: PRK00029
405416008857	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
405416008858	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
405416008859	active site
405416008860	phosphorylation site [posttranslational modification]
405416008861	intermolecular recognition site; other site
405416008862	dimerization interface [polypeptide binding]; other site
405416008863	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
405416008864	DNA binding site [nucleotide binding]
405416008865	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
405416008866	dimerization interface [polypeptide binding]; other site
405416008867	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
405416008868	dimer interface [polypeptide binding]; other site
405416008869	phosphorylation site [posttranslational modification]
405416008870	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
405416008871	ATP binding site [chemical binding]; other site
405416008872	Mg2+ binding site [ion binding]; other site
405416008873	G-X-G motif; other site
405416008874	Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418
405416008875	acyl-CoA dehydrogenase; Provisional; Region: PTZ00456
405416008876	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
405416008877	active site
405416008878	Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806
405416008879	acyl-CoA dehydrogenase; Provisional; Region: PTZ00456
405416008880	Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418
405416008881	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
405416008882	active site
405416008883	Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806
405416008884	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
405416008885	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
405416008886	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
405416008887	putative effector binding pocket; other site
405416008888	dimerization interface [polypeptide binding]; other site
405416008889	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
405416008890	GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057
405416008891	C-terminal domain interface [polypeptide binding]; other site
405416008892	GSH binding site (G-site) [chemical binding]; other site
405416008893	dimer interface [polypeptide binding]; other site
405416008894	C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188
405416008895	dimer interface [polypeptide binding]; other site
405416008896	substrate binding pocket (H-site) [chemical binding]; other site
405416008897	N-terminal domain interface [polypeptide binding]; other site
405416008898	Predicted membrane protein [Function unknown]; Region: COG3223
405416008899	Domain of unknown function (DUF3315); Region: DUF3315; pfam11776
405416008900	Putative catalytic domain, repeat 1, of uncharacterized phospholipase D-like proteins; Region: PLDc_unchar2_1; cd09129
405416008901	putative active site [active]
405416008902	putative catalytic site [active]
405416008903	Putative catalytic domain, repeat 2, of uncharacterized phospholipase D-like proteins; Region: PLDc_unchar2_2; cd09130
405416008904	PLD-like domain; Region: PLDc_2; pfam13091
405416008905	putative active site [active]
405416008906	putative catalytic site [active]
405416008907	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
405416008908	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
405416008909	N-terminal plug; other site
405416008910	ligand-binding site [chemical binding]; other site
405416008911	Domain of unknown function (DUF4184); Region: DUF4184; pfam13803
405416008912	aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476
405416008913	EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317
405416008914	dimer interface [polypeptide binding]; other site
405416008915	anticodon binding site; other site
405416008916	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
405416008917	homodimer interface [polypeptide binding]; other site
405416008918	motif 1; other site
405416008919	active site
405416008920	motif 2; other site
405416008921	GAD domain; Region: GAD; pfam02938
405416008922	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
405416008923	active site
405416008924	motif 3; other site
405416008925	Protein of unknown function (DUF3184); Region: DUF3184; pfam11380
405416008926	Glycosyltransferase family 25 [lipooligosaccharide (LOS) biosynthesis protein] is a family of glycosyltransferases involved in LOS biosynthesis. The members include the beta(1,4) galactosyltransferases: Lgt2 of Moraxella catarrhalis, LgtB and LgtE of...; Region: Glyco_transf_25; cd06532
405416008927	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
405416008928	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
405416008929	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
405416008930	UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511
405416008931	putative metal binding site; other site
405416008932	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
405416008933	Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918
405416008934	putative active site [active]
405416008935	putative metal binding site [ion binding]; other site
405416008936	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736
405416008937	phosphorylation site [posttranslational modification]
405416008938	Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524
405416008939	Predicted nucleoside-diphosphate-sugar epimerase [Cell envelope biogenesis, outer membrane]; Region: COG3660
405416008940	Mitochondrial fission ELM1; Region: Mito_fiss_Elm1; pfam06258
405416008941	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
405416008942	BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids  leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557
405416008943	homodimer interface [polypeptide binding]; other site
405416008944	substrate-cofactor binding pocket; other site
405416008945	catalytic residue [active]
405416008946	bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Reviewed; Region: PRK11072
405416008947	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
405416008948	metal binding triad; other site
405416008949	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
405416008950	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
405416008951	metal binding triad; other site
405416008952	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
405416008953	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
405416008954	dimer interface [polypeptide binding]; other site
405416008955	phosphorylation site [posttranslational modification]
405416008956	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
405416008957	ATP binding site [chemical binding]; other site
405416008958	Mg2+ binding site [ion binding]; other site
405416008959	G-X-G motif; other site
405416008960	KAP family P-loop domain; Region: KAP_NTPase; pfam07693
405416008961	Predicted P-loop ATPase [General function prediction only]; Region: COG4928
405416008962	Omega-hydroxypalmitate O-feruloyl transferase; Region: PLN02481; cl03601
405416008963	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147
405416008964	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113
405416008965	LemA family; Region: LemA; cl00742
405416008966	queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112
405416008967	Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343
405416008968	preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585
405416008969	SecD export protein N-terminal TM region; Region: SecD-TM1; pfam13721
405416008970	preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812
405416008971	SecD/SecF GG Motif; Region: Sec_GG; pfam07549
405416008972	protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916
405416008973	preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022
405416008974	SecD/SecF GG Motif; Region: Sec_GG; pfam07549
405416008975	Protein export membrane protein; Region: SecD_SecF; pfam02355
405416008976	bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579
405416008977	Flavoprotein; Region: Flavoprotein; pfam02441
405416008978	DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127
405416008979	hypothetical protein; Reviewed; Region: PRK00024
405416008980	Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
405416008981	MPN+ (JAMM) motif; other site
405416008982	Zinc-binding site [ion binding]; other site
405416008983	Bestrophin, RFP-TM, chloride channel; Region: Bestrophin; pfam01062
405416008984	Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613
405416008985	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438
405416008986	active site
405416008987	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438
405416008988	Intracellular septation protein A; Region: IspA; pfam04279
405416008989	YciI-like protein; Reviewed; Region: PRK11370
405416008990	bifunctional tRNA (mnm(5)s(2)U34)-methyltransferase/FAD-dependent cmnm(5)s(2)U34 oxidoreductase; Reviewed; Region: mnmC; PRK01747
405416008991	Uncharacterized conserved protein [Function unknown]; Region: COG4121
405416008992	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
405416008993	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
405416008994	active site residue [active]
405416008995	Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cl00723
405416008996	Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cl00723
405416008997	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
405416008998	CoenzymeA binding site [chemical binding]; other site
405416008999	subunit interaction site [polypeptide binding]; other site
405416009000	PHB binding site; other site
405416009001	Brown fat-inducible thioesterase (BFIT).  Brain acyl-CoA hydrolase (BACH).  These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442
405416009002	thioredoxin 2; Provisional; Region: PRK10996
405416009003	zinc-ribbon domain; Region: zinc_ribbon_5; cl11777
405416009004	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
405416009005	catalytic residues [active]
405416009006	Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073
405416009007	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
405416009008	Putative phosphatase (DUF442); Region: DUF442; cl17385
405416009009	dihydrolipoamide dehydrogenase; Validated; Region: PRK06292
405416009010	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
405416009011	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
405416009012	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
405416009013	Domain of unknown function (DUF4154); Region: DUF4154; pfam13689
405416009014	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
405416009015	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
405416009016	metal binding site [ion binding]; metal-binding site
405416009017	active site
405416009018	I-site; other site
405416009019	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
405416009020	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
405416009021	ligand binding site [chemical binding]; other site
405416009022	phosphodiesterase YaeI; Provisional; Region: PRK11340
405416009023	Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385
405416009024	putative active site [active]
405416009025	putative metal binding site [ion binding]; other site
405416009026	Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502
405416009027	Putative catalytic domain, repeat 1, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_1; cd09111
405416009028	putative active site [active]
405416009029	catalytic site [active]
405416009030	Putative catalytic domain, repeat 2, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_2; cd09113
405416009031	putative active site [active]
405416009032	catalytic site [active]
405416009033	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
405416009034	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
405416009035	putative acyl-acceptor binding pocket; other site
405416009036	GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167
405416009037	GTP-binding protein HflX; Region: GTP_HflX; TIGR03156
405416009038	HflX GTPase family; Region: HflX; cd01878
405416009039	G1 box; other site
405416009040	GTP/Mg2+ binding site [chemical binding]; other site
405416009041	Switch I region; other site
405416009042	G2 box; other site
405416009043	G3 box; other site
405416009044	Switch II region; other site
405416009045	G4 box; other site
405416009046	G5 box; other site
405416009047	LrgB-like family; Region: LrgB; cl00596
405416009048	Uncharacterized protein conserved in bacteria (DUF2147); Region: DUF2147; pfam09917
405416009049	diadenosine tetraphosphatase; Reviewed; Region: apaH; PRK00166
405416009050	Escherichia coli ApaH and related proteins, metallophosphatase domain; Region: MPP_ApaH; cd07422
405416009051	active site
405416009052	metal binding site [ion binding]; metal-binding site
405416009053	16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274
405416009054	Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030
405416009055	4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743
405416009056	4-hydroxythreonine-4-phosphate dehydrogenase; Region: pdxA; TIGR00557
405416009057	Ribosomal protein L13.  Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392
405416009058	23S rRNA interface [nucleotide binding]; other site
405416009059	L3 interface [polypeptide binding]; other site
405416009060	30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132
405416009061	stringent starvation protein A; Provisional; Region: sspA; PRK09481
405416009062	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
405416009063	C-terminal, alpha helical domain of Stringent starvation protein A; Region: GST_C_SspA; cd03186
405416009064	dimer interface [polypeptide binding]; other site
405416009065	N-terminal domain interface [polypeptide binding]; other site
405416009066	ClpXP protease specificity-enhancing factor; Provisional; Region: PRK11798
405416009067	Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770
405416009068	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
405416009069	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
405416009070	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785
405416009071	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
405416009072	carboxyltransferase (CT) interaction site; other site
405416009073	biotinylation site [posttranslational modification]; other site
405416009074	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
405416009075	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
405416009076	substrate binding site [chemical binding]; other site
405416009077	oxyanion hole (OAH) forming residues; other site
405416009078	trimer interface [polypeptide binding]; other site
405416009079	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
405416009080	Helix-turn-helix domain; Region: HTH_38; pfam13936
405416009081	Homeodomain-like domain; Region: HTH_32; pfam13565
405416009082	Integrase core domain; Region: rve; pfam00665
405416009083	Integrase core domain; Region: rve_3; cl15866
405416009084	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
405416009085	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
405416009086	active site
405416009087	Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799
405416009088	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
405416009089	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
405416009090	Trans-2-enoyl-CoA reductase (TER) and 2,4-dienoyl-CoA reductase (DECR), atypical (a) SDR; Region: TER_DECR_SDR_a; cd05369
405416009091	NAD(P) binding site [chemical binding]; other site
405416009092	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
405416009093	substrate binding site [chemical binding]; other site
405416009094	homotetramer interface [polypeptide binding]; other site
405416009095	active site
405416009096	homodimer interface [polypeptide binding]; other site
405416009097	Protein of unknown function (DUF1446); Region: DUF1446; pfam07287
405416009098	RUN domain; Region: RUN; cl02689
405416009099	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
405416009100	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
405416009101	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
405416009102	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
405416009103	active site
405416009104	Protein of unknown function (DUF4256); Region: DUF4256; pfam14066
405416009105	Domain of unknown function (DUF2007); Region: DUF2007; pfam09413
405416009106	Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183
405416009107	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066
405416009108	Protein involved in catabolism of external DNA [General function prediction only]; Region: ComJ; COG2961
405416009109	Predicted proline hydroxylase [Posttranslational modification, protein turnover, chaperones]; Region: EGL-9; COG3751
405416009110	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; pfam13640
405416009111	Protein of unknown function (DUF2789); Region: DUF2789; pfam10982
405416009112	malate dehydrogenase; Provisional; Region: PRK05442
405416009113	Chloroplast-like malate dehydrogenases; Region: MDH_choloroplast_like; cd01338
405416009114	NAD(P) binding site [chemical binding]; other site
405416009115	dimer interface [polypeptide binding]; other site
405416009116	malate binding site [chemical binding]; other site
405416009117	Ribonuclease T2 (RNase T2) is a widespread family of secreted RNases found in every organism examined thus far.  This family includes RNase Rh, RNase MC1, RNase LE, and self-incompatibility RNases (S-RNases).  Plant T2 RNases are expressed during leaf...; Region: RNase_T2_prok; cd01062
405416009118	B1 nucleotide binding pocket [chemical binding]; other site
405416009119	B2 nucleotide binding pocket [chemical binding]; other site
405416009120	CAS motifs; other site
405416009121	active site
405416009122	lytic murein transglycosylase; Provisional; Region: PRK11619
405416009123	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
405416009124	N-acetyl-D-glucosamine binding site [chemical binding]; other site
405416009125	catalytic residue [active]
405416009126	(dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325
405416009127	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
405416009128	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
405416009129	FeS/SAM binding site; other site
405416009130	TRAM domain; Region: TRAM; cl01282
405416009131	Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702
405416009132	PhoH-like protein; Region: PhoH; pfam02562
405416009133	metal-binding heat shock protein; Provisional; Region: PRK00016
405416009134	Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810
405416009135	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
405416009136	Protein of unknown function (DUF3108); Region: DUF3108; pfam11306
405416009137	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
405416009138	active site
405416009139	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
405416009140	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
405416009141	Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918
405416009142	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
405416009143	EamA-like transporter family; Region: EamA; pfam00892
405416009144	Helix-turn-helix domain; Region: HTH_18; pfam12833
405416009145	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
405416009146	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
405416009147	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421
405416009148	YcxB-like protein; Region: YcxB; pfam14317
405416009149	Nitroreductase-like family 4.  A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_4; cd02140
405416009150	dimer interface [polypeptide binding]; other site
405416009151	FMN binding site [chemical binding]; other site
405416009152	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
405416009153	ribonuclease R; Region: RNase_R; TIGR02063
405416009154	RNB domain; Region: RNB; pfam00773
405416009155	S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471
405416009156	RNA binding site [nucleotide binding]; other site
405416009157	Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339
405416009158	Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456
405416009159	active site
405416009160	Zn binding site [ion binding]; other site
405416009161	Probable metal-binding protein (DUF2387); Region: DUF2387; pfam09526
405416009162	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274
405416009163	rhomboid family GlyGly-CTERM serine protease; Region: rhom_GG_sort; TIGR03902
405416009164	Flavinator of succinate dehydrogenase; Region: Sdh5; pfam03937
405416009165	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
405416009166	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
405416009167	active site
405416009168	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
405416009169	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
405416009170	50S ribosomal protein L17; Validated; Region: rplQ; PRK05591
405416009171	DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182
405416009172	N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928
405416009173	alphaNTD homodimer interface [polypeptide binding]; other site
405416009174	alphaNTD - beta interaction site [polypeptide binding]; other site
405416009175	alphaNTD - beta' interaction site [polypeptide binding]; other site
405416009176	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118
405416009177	30S ribosomal protein S4; Validated; Region: rpsD; PRK05327
405416009178	Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163
405416009179	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
405416009180	RNA binding surface [nucleotide binding]; other site
405416009181	30S ribosomal protein S11; Validated; Region: PRK05309
405416009182	30S ribosomal protein S13; Validated; Region: rpsM; PRK05179
405416009183	30S ribosomal protein S13; Region: bact_S13; TIGR03631
405416009184	Ribosomal protein L36; Region: Ribosomal_L36; pfam00444
405416009185	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204
405416009186	SecY translocase; Region: SecY; pfam00344
405416009187	50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592
405416009188	Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658
405416009189	23S rRNA binding site [nucleotide binding]; other site
405416009190	30S ribosomal protein S5; Validated; Region: rpsE; PRK00550
405416009191	Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333
405416009192	Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719
405416009193	Ribosomal L18/L5e:  L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432
405416009194	5S rRNA interface [nucleotide binding]; other site
405416009195	23S rRNA interface [nucleotide binding]; other site
405416009196	L5 interface [polypeptide binding]; other site
405416009197	50S ribosomal protein L6; Validated; Region: rplF; PRK05498
405416009198	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
405416009199	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
405416009200	30S ribosomal protein S8; Validated; Region: rpsH; PRK00136
405416009201	30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881
405416009202	50S ribosomal protein L5; Validated; Region: rplE; PRK00010
405416009203	Ribosomal protein L5; Region: Ribosomal_L5; pfam00281
405416009204	ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673
405416009205	50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004
405416009206	KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089
405416009207	RNA binding site [nucleotide binding]; other site
405416009208	50S ribosomal protein L14; Validated; Region: rplN; PRK05483
405416009209	30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610
405416009210	Ribosomal L29 protein/HIP.  L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals.  L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427
405416009211	23S rRNA interface [nucleotide binding]; other site
405416009212	putative translocon interaction site; other site
405416009213	signal recognition particle (SRP54) interaction site; other site
405416009214	L23 interface [polypeptide binding]; other site
405416009215	trigger factor interaction site; other site
405416009216	Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433
405416009217	23S rRNA interface [nucleotide binding]; other site
405416009218	5S rRNA interface [nucleotide binding]; other site
405416009219	putative antibiotic binding site [chemical binding]; other site
405416009220	L25 interface [polypeptide binding]; other site
405416009221	L27 interface [polypeptide binding]; other site
405416009222	30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310
405416009223	K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3  is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel.  The KH...; Region: 30S_S3_KH; cd02412
405416009224	G-X-X-G motif; other site
405416009225	Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189
405416009226	Ribosomal protein L22/L17e.  L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit.  It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336
405416009227	putative translocon binding site; other site
405416009228	protein-rRNA interface [nucleotide binding]; other site
405416009229	30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357
405416009230	50S ribosomal protein L2; Validated; Region: rplB; PRK09374
405416009231	Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181
405416009232	Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947
405416009233	50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738
405416009234	50S ribosomal protein L4; Provisional; Region: rplD; PRK05319
405416009235	50S ribosomal protein L3; Validated; Region: rplC; PRK00001
405416009236	30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596
405416009237	GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518
405416009238	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741
405416009239	catalytic triad [active]
405416009240	cystathionine beta-lyase; Provisional; Region: PRK07050
405416009241	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
405416009242	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
405416009243	catalytic residue [active]
405416009244	Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872
405416009245	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
405416009246	Walker A motif; other site
405416009247	ATP binding site [chemical binding]; other site
405416009248	Walker B motif; other site
405416009249	Zonular occludens toxin (Zot); Region: Zot; cl17485
405416009250	Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040
405416009251	heme-binding site [chemical binding]; other site
405416009252	Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868
405416009253	FAD binding pocket [chemical binding]; other site
405416009254	conserved FAD binding motif [chemical binding]; other site
405416009255	phosphate binding motif [ion binding]; other site
405416009256	Transcriptional regulator; Region: Rrf2; cl17282
405416009257	Rrf2 family protein; Region: rrf2_super; TIGR00738
405416009258	YihA (EngB) GTPase family; Region: YihA_EngB; cd01876
405416009259	G1 box; other site
405416009260	GTP/Mg2+ binding site [chemical binding]; other site
405416009261	Switch I region; other site
405416009262	G2 box; other site
405416009263	G3 box; other site
405416009264	Switch II region; other site
405416009265	G4 box; other site
405416009266	G5 box; other site
405416009267	Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687
405416009268	Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118
405416009269	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
405416009270	Sodium:dicarboxylate symporter family; Region: SDF; pfam00375
405416009271	Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946
405416009272	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445
405416009273	active site
405416009274	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444
405416009275	catalytic triad [active]
405416009276	dimer interface [polypeptide binding]; other site
405416009277	glycerol-3-phosphate O-acyltransferase; Region: plsB; TIGR03703
405416009278	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Region: LPLAT_DHAPAT-like; cd07993
405416009279	putative acyl-acceptor binding pocket; other site
405416009280	lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096
405416009281	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
405416009282	NADH(P)-binding; Region: NAD_binding_10; pfam13460
405416009283	NAD(P) binding site [chemical binding]; other site
405416009284	active site
405416009285	ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917
405416009286	RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488
405416009287	ssDNA binding site; other site
405416009288	generic binding surface II; other site
405416009289	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
405416009290	ATP binding site [chemical binding]; other site
405416009291	putative Mg++ binding site [ion binding]; other site
405416009292	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
405416009293	nucleotide binding region [chemical binding]; other site
405416009294	ATP-binding site [chemical binding]; other site
405416009295	comF family protein; Region: comF; TIGR00201
405416009296	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
405416009297	active site
405416009298	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_31; cd04690
405416009299	nudix motif; other site
405416009300	Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695
405416009301	Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598
405416009302	Escherichia coli Mg2+ transporter CorA_like subgroup; Region: EcCorA-like_1; cd12835
405416009303	Cl binding site [ion binding]; other site
405416009304	oligomer interface [polypeptide binding]; other site
405416009305	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
405416009306	anti sigma factor interaction site; other site
405416009307	regulatory phosphorylation site [posttranslational modification]; other site
405416009308	Toluene tolerance, Ttg2; Region: Tol_Tol_Ttg2; pfam05494
405416009309	ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463
405416009310	mce related protein; Region: MCE; pfam02470
405416009311	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
405416009312	Permease; Region: Permease; cl00510
405416009313	ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127
405416009314	ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261
405416009315	Walker A/P-loop; other site
405416009316	ATP binding site [chemical binding]; other site
405416009317	Q-loop/lid; other site
405416009318	ABC transporter signature motif; other site
405416009319	Walker B; other site
405416009320	D-loop; other site
405416009321	H-loop/switch region; other site
405416009322	ATP-dependent RNA helicase RhlB; Provisional; Region: PRK04837
405416009323	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
405416009324	ATP binding site [chemical binding]; other site
405416009325	Mg++ binding site [ion binding]; other site
405416009326	motif III; other site
405416009327	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
405416009328	nucleotide binding region [chemical binding]; other site
405416009329	ATP-binding site [chemical binding]; other site
405416009330	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
405416009331	IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639
405416009332	active site
405416009333	dimerization interface [polypeptide binding]; other site
405416009334	1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444
405416009335	Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007
405416009336	TPP-binding site; other site
405416009337	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
405416009338	PYR/PP interface [polypeptide binding]; other site
405416009339	dimer interface [polypeptide binding]; other site
405416009340	TPP binding site [chemical binding]; other site
405416009341	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
405416009342	GTP cyclohydrolase II (RibA).  GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641
405416009343	dimerization interface [polypeptide binding]; other site
405416009344	active site
405416009345	coproporphyrinogen III oxidase; Provisional; Region: PRK05330
405416009346	Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; pfam01218
405416009347	shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258
405416009348	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
405416009349	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
405416009350	shikimate binding site; other site
405416009351	NAD(P) binding site [chemical binding]; other site
405416009352	Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418
405416009353	acyl-CoA dehydrogenase; Provisional; Region: PTZ00456
405416009354	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
405416009355	active site
405416009356	Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806
405416009357	hypothetical protein; Provisional; Region: PRK11615
405416009358	PspC domain; Region: PspC; pfam04024
405416009359	CBS-domain-containing membrane protein [Signal transduction mechanisms]; Region: COG3448
405416009360	HPP family; Region: HPP; pfam04982
405416009361	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
405416009362	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the HPP motif domain. These proteins are integral membrane proteins with four transmembrane spanning helices. The function of these proteins is...; Region: CBS_pair_HPP_assoc; cd04600
405416009363	probable DNA metabolism protein; Region: SAM_7_link_chp; TIGR03915
405416009364	putative DNA modification/repair radical SAM protein; Region: rSAM_link_UDG; TIGR03916
405416009365	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
405416009366	FeS/SAM binding site; other site
405416009367	Protein of unknown function (DUF1311); Region: DUF1311; pfam07007
405416009368	Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733
405416009369	dimer interface [polypeptide binding]; other site
405416009370	motif 1; other site
405416009371	active site
405416009372	motif 2; other site
405416009373	motif 3; other site
405416009374	glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233
405416009375	YCII-related domain; Region: YCII; cl00999
405416009376	EamA-like transporter family; Region: EamA; pfam00892
405416009377	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
405416009378	EamA-like transporter family; Region: EamA; pfam00892
405416009379	Transcriptional regulator [Transcription]; Region: LysR; COG0583
405416009380	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
405416009381	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
405416009382	dimerization interface [polypeptide binding]; other site
405416009383	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459
405416009384	active site
405416009385	catalytic residues [active]
405416009386	Peptidase M14 Succinylglutamate desuccinylase (ASTE) subfamily; Region: M14_ASTE; cd03855
405416009387	Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952
405416009388	putative active site [active]
405416009389	Zn binding site [ion binding]; other site
405416009390	succinylarginine dihydrolase; Provisional; Region: PRK13281
405416009391	succinylglutamic semialdehyde dehydrogenase; Reviewed; Region: astD; PRK09457
405416009392	N-succinylglutamate 5-semialdehyde dehydrogenase, AstD-like; Region: ALDH_SGSD_AstD; cd07095
405416009393	NAD(P) binding site [chemical binding]; other site
405416009394	catalytic residues [active]
405416009395	Arginine/ornithine N-succinyltransferase beta subunit [Amino acid transport and metabolism]; Region: AstA; COG3138
405416009396	Arginine N-succinyltransferase beta subunit; Region: AstA; cl11440
405416009397	bifunctional succinylornithine transaminase/acetylornithine transaminase; Provisional; Region: PRK12381
405416009398	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
405416009399	inhibitor-cofactor binding pocket; inhibition site
405416009400	pyridoxal 5'-phosphate binding site [chemical binding]; other site
405416009401	catalytic residue [active]
405416009402	Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334
405416009403	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
405416009404	NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076
405416009405	NAD(P) binding site [chemical binding]; other site
405416009406	S-methylmethionine transporter; Provisional; Region: PRK11387
405416009407	Methyltransferase domain; Region: Methyltransf_23; pfam13489
405416009408	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
405416009409	S-adenosylmethionine binding site [chemical binding]; other site
405416009410	Endonuclease related to archaeal Holliday junction resolvase; Region: Endonuc_Holl; cl01958
405416009411	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
405416009412	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
405416009413	Magnesium ion binding site [ion binding]; other site
405416009414	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
405416009415	Domain of unknown function DUF20; Region: UPF0118; pfam01594
405416009416	Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032
405416009417	Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305
405416009418	E-class dimer interface [polypeptide binding]; other site
405416009419	P-class dimer interface [polypeptide binding]; other site
405416009420	active site
405416009421	Cu2+ binding site [ion binding]; other site
405416009422	Zn2+ binding site [ion binding]; other site
405416009423	FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805
405416009424	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
405416009425	multidrug efflux system translocase MdfA; Provisional; Region: PRK15402
405416009426	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
405416009427	putative substrate translocation pore; other site
405416009428	Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249
405416009429	Uncharacterized conserved protein [Function unknown]; Region: COG1359
405416009430	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
405416009431	FAD binding domain; Region: FAD_binding_4; pfam01565
405416009432	D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790
405416009433	Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_3; cd12176
405416009434	ligand binding site [chemical binding]; other site
405416009435	NAD binding site [chemical binding]; other site
405416009436	tetramer interface [polypeptide binding]; other site
405416009437	catalytic site [active]
405416009438	C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901
405416009439	L-serine binding site [chemical binding]; other site
405416009440	ACT domain interface; other site
405416009441	threonine and homoserine efflux system; Provisional; Region: PRK10532
405416009442	EamA-like transporter family; Region: EamA; pfam00892
405416009443	Threonine/homoserine efflux transporter [Amino acid transport and metabolism]; Region: rhtA; COG5006
405416009444	Hemerythrin-like domain; Region: Hr-like; cd12108
405416009445	hypothetical protein; Provisional; Region: PRK10621
405416009446	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
405416009447	tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05033
405416009448	Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573
405416009449	RNA binding site [nucleotide binding]; other site
405416009450	active site
405416009451	Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157
405416009452	lipase chaperone; Provisional; Region: PRK01294
405416009453	Proteobacterial lipase chaperone protein; Region: Lipase_chap; pfam03280
405416009454	Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075
405416009455	Putative serine esterase (DUF676); Region: DUF676; pfam05057
405416009456	50S ribosomal protein L19; Provisional; Region: rplS; PRK05338
405416009457	tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026
405416009458	16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122
405416009459	RimM N-terminal domain; Region: RimM; pfam01782
405416009460	PRC-barrel domain; Region: PRC; pfam05239
405416009461	30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040
405416009462	Tfp pilus assembly protein PilE [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilE; COG4968
405416009463	Tfp pilus assembly protein PilE [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilE; COG4968
405416009464	von Willebrand factor type A domain; Region: VWA_2; pfam13519
405416009465	Neisseria PilC beta-propeller domain; Region: Neisseria_PilC; pfam05567
405416009466	type IV pilus modification protein PilV; Region: type_IV_pilV; TIGR02523
405416009467	Tfp pilus assembly protein FimT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimT; COG4970
405416009468	4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045
405416009469	4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761
405416009470	Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194
405416009471	Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071
405416009472	catalytic site [active]
405416009473	G-X2-G-X-G-K; other site
405416009474	DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392
405416009475	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
405416009476	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
405416009477	Zn2+ binding site [ion binding]; other site
405416009478	Mg2+ binding site [ion binding]; other site
405416009479	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
405416009480	synthetase active site [active]
405416009481	NTP binding site [chemical binding]; other site
405416009482	metal binding site [ion binding]; metal-binding site
405416009483	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
405416009484	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
405416009485	ACT domain; Region: ACT_4; pfam13291
405416009486	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
405416009487	homotrimer interaction site [polypeptide binding]; other site
405416009488	putative active site [active]
405416009489	Bacterioferritin-associated ferredoxin [Inorganic ion transport and metabolism]; Region: Bfd; COG2906
405416009490	Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193
405416009491	Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907
405416009492	heme binding site [chemical binding]; other site
405416009493	ferroxidase pore; other site
405416009494	ferroxidase diiron center [ion binding]; other site
405416009495	Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307
405416009496	O-Antigen ligase; Region: Wzy_C; pfam04932
405416009497	Domain of unknown function (DUF3366); Region: DUF3366; pfam11846
405416009498	O-antigen ligase like membrane protein; Region: O-antigen_lig; pfam13425
405416009499	Tfp pilus assembly protein, major pilin PilA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilA; COG4969
405416009500	Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544
405416009501	Pilin (bacterial filament); Region: Pilin; pfam00114
405416009502	Repair protein; Region: Repair_PSII; pfam04536
405416009503	Repair protein; Region: Repair_PSII; pfam04536
405416009504	LemA family; Region: LemA; pfam04011
405416009505	Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687
405416009506	Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118
405416009507	glutamate synthase small subunit family protein, proteobacterial; Region: gltD_gamma_fam; TIGR01318
405416009508	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
405416009509	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
405416009510	glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750
405416009511	Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713
405416009512	active site
405416009513	dimer interface [polypeptide binding]; other site
405416009514	Glutamate synthase central domain; Region: Glu_syn_central; pfam04898
405416009515	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
405416009516	active site
405416009517	FMN binding site [chemical binding]; other site
405416009518	substrate binding site [chemical binding]; other site
405416009519	3Fe-4S cluster binding site [ion binding]; other site
405416009520	gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982
405416009521	domain interface; other site
405416009522	Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195
405416009523	active site
405416009524	dimer interface [polypeptide binding]; other site
405416009525	metal binding site [ion binding]; metal-binding site
405416009526	shikimate kinase; Reviewed; Region: aroK; PRK00131
405416009527	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
405416009528	ADP binding site [chemical binding]; other site
405416009529	magnesium binding site [ion binding]; other site
405416009530	putative shikimate binding site; other site
405416009531	AMIN domain; Region: AMIN; pfam11741
405416009532	type IV pilus secretin (or competence protein) PilQ; Region: IV_pilus_PilQ; TIGR02515
405416009533	Secretin and TonB N terminus short domain; Region: STN; smart00965
405416009534	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
405416009535	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
405416009536	Tfp pilus assembly protein PilP [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilP; COG3168
405416009537	Pilus assembly protein, PilP; Region: PilP; pfam04351
405416009538	Pilus assembly protein, PilO; Region: PilO; pfam04350
405416009539	Tfp pilus assembly protein PilN [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilN; COG3166
405416009540	Fimbrial assembly protein (PilN); Region: PilN; pfam05137
405416009541	Competence protein A; Region: Competence_A; pfam11104
405416009542	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
405416009543	Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane]; Region: MrcA; COG5009
405416009544	Transglycosylase; Region: Transgly; pfam00912
405416009545	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
405416009546	23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088
405416009547	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
405416009548	S-adenosylmethionine binding site [chemical binding]; other site
405416009549	phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108
405416009550	Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852
405416009551	Mg++ binding site [ion binding]; other site
405416009552	putative catalytic motif [active]
405416009553	putative substrate binding site [chemical binding]; other site
405416009554	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
405416009555	UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Region: murF; TIGR01143
405416009556	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
405416009557	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
405416009558	UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139
405416009559	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
405416009560	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
405416009561	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
405416009562	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
405416009563	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
405416009564	Cell division protein FtsL; Region: FtsL; pfam04999
405416009565	16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050
405416009566	MraW methylase family; Region: Methyltransf_5; cl17771
405416009567	ABC-type sulfate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: Sbp; COG1613
405416009568	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
405416009569	glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
405416009570	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
405416009571	active site
405416009572	HIGH motif; other site
405416009573	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
405416009574	active site
405416009575	KMSKS motif; other site
405416009576	S-methylmethionine transporter; Provisional; Region: PRK11387
405416009577	Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230
405416009578	heavy metal efflux pump, CzcA family; Region: 2A0601; TIGR00914
405416009579	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
405416009580	Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999
405416009581	HlyD family secretion protein; Region: HlyD_3; pfam13437
405416009582	Outer membrane efflux protein; Region: OEP; pfam02321
405416009583	Outer membrane efflux protein; Region: OEP; pfam02321
405416009584	hypothetical protein; Provisional; Region: PRK10215
405416009585	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
405416009586	Sel1-like repeats; Region: SEL1; smart00671
405416009587	putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819
405416009588	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
405416009589	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
405416009590	ABC transporter; Region: ABC_tran_2; pfam12848
405416009591	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
405416009592	O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK06084
405416009593	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
405416009594	homodimer interface [polypeptide binding]; other site
405416009595	substrate-cofactor binding pocket; other site
405416009596	pyridoxal 5'-phosphate binding site [chemical binding]; other site
405416009597	catalytic residue [active]
405416009598	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
405416009599	classical (c) SDRs; Region: SDR_c; cd05233
405416009600	NAD(P) binding site [chemical binding]; other site
405416009601	active site
405416009602	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
405416009603	Sulfate transporter family; Region: Sulfate_transp; pfam00916
405416009604	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378
405416009605	active site clefts [active]
405416009606	zinc binding site [ion binding]; other site
405416009607	dimer interface [polypeptide binding]; other site
405416009608	Transcriptional accessory protein [Transcription]; Region: Tex; COG2183
405416009609	Tex-like protein N-terminal domain; Region: Tex_N; pfam09371
405416009610	Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732
405416009611	S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685
405416009612	RNA binding site [nucleotide binding]; other site
405416009613	osmolarity response regulator; Provisional; Region: ompR; PRK09468
405416009614	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
405416009615	active site
405416009616	phosphorylation site [posttranslational modification]
405416009617	intermolecular recognition site; other site
405416009618	dimerization interface [polypeptide binding]; other site
405416009619	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
405416009620	DNA binding site [nucleotide binding]
405416009621	osmolarity sensor protein; Provisional; Region: envZ; PRK09467
405416009622	HAMP domain; Region: HAMP; pfam00672
405416009623	dimerization interface [polypeptide binding]; other site
405416009624	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
405416009625	dimer interface [polypeptide binding]; other site
405416009626	phosphorylation site [posttranslational modification]
405416009627	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
405416009628	ATP binding site [chemical binding]; other site
405416009629	Mg2+ binding site [ion binding]; other site
405416009630	G-X-G motif; other site
405416009631	Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550
405416009632	succinate CoA transferase; Region: YgfH_subfam; TIGR03458
405416009633	Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336
405416009634	putative acetyltransferase; Provisional; Region: PRK03624
405416009635	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
405416009636	Coenzyme A binding pocket [chemical binding]; other site
405416009637	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
405416009638	Coenzyme A binding pocket [chemical binding]; other site
405416009639	Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914
405416009640	putative active site pocket [active]
405416009641	4-fold oligomerization interface [polypeptide binding]; other site
405416009642	metal binding residues [ion binding]; metal-binding site
405416009643	3-fold/trimer interface [polypeptide binding]; other site
405416009644	imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141
405416009645	Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748
405416009646	putative active site [active]
405416009647	oxyanion strand; other site
405416009648	catalytic triad [active]
405416009649	Protein of unknown function (DUF805); Region: DUF805; pfam05656
405416009650	DEDDy 3'-5' exonuclease domain of WRN and similar proteins; Region: WRN_exo; cd06141
405416009651	catalytic site [active]
405416009652	putative active site [active]
405416009653	putative substrate binding site [chemical binding]; other site
405416009654	HisA.  Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732
405416009655	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
405416009656	catalytic residues [active]
405416009657	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
405416009658	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
405416009659	non-specific DNA binding site [nucleotide binding]; other site
405416009660	salt bridge; other site
405416009661	sequence-specific DNA binding site [nucleotide binding]; other site
405416009662	EamA-like transporter family; Region: EamA; pfam00892
405416009663	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
405416009664	Predicted membrane protein [Function unknown]; Region: COG3671
405416009665	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
405416009666	DNA-binding site [nucleotide binding]; DNA binding site
405416009667	RNA-binding motif; other site
405416009668	Protein of unknown function (DUF1294); Region: DUF1294; pfam06961
405416009669	Homoserine Kinase, type II. Homoserine kinase is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and...; Region: HomoserineK_II; cd05153
405416009670	Phosphotransferase enzyme family; Region: APH; pfam01636
405416009671	putative active site [active]
405416009672	putative substrate binding site [chemical binding]; other site
405416009673	ATP binding site [chemical binding]; other site
405416009674	The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731
405416009675	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
405416009676	substrate binding site [chemical binding]; other site
405416009677	glutamase interaction surface [polypeptide binding]; other site
405416009678	Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625
405416009679	Helix-turn-helix domain; Region: HTH_18; pfam12833
405416009680	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
405416009681	Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333
405416009682	amphipathic channel; other site
405416009683	Asn-Pro-Ala signature motifs; other site
405416009684	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
405416009685	DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases.  They exists as monomers and homodimers; Region: NUC; cd00091
405416009686	DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892
405416009687	active site
405416009688	substrate binding site [chemical binding]; other site
405416009689	Mg2+ binding site [ion binding]; other site
405416009690	K+ transporter [Inorganic ion transport and metabolism]; Region: Kup; COG3158
405416009691	potassium uptake protein; Region: kup; TIGR00794
405416009692	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
405416009693	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
405416009694	isoprenoid biosynthesis protein with amidotransferase-like domain; Provisional; Region: PRK11780
405416009695	Type 1 glutamine amidotransferase (GATase1)-like domain found in zebrafish ES1; Region: GATase1_ES1; cd03133
405416009696	conserved cys residue [active]
405416009697	Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525
405416009698	Predicted transcriptional regulators [Transcription]; Region: COG1733
405416009699	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
405416009700	Domain of unknown function (DUF4263); Region: DUF4263; pfam14082
405416009701	Predicted transcriptional regulators [Transcription]; Region: COG1733
405416009702	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
405416009703	Uncharacterized conserved protein [Function unknown]; Region: COG2128
405416009704	Carboxymuconolactone decarboxylase family; Region: CMD; cl00460
405416009705	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
405416009706	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
405416009707	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
405416009708	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
405416009709	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
405416009710	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
405416009711	active site
405416009712	catalytic tetrad [active]
405416009713	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
405416009714	EamA-like transporter family; Region: EamA; pfam00892
405416009715	DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906
405416009716	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
405416009717	The C-terminal substrate binding domain of LysR-type transcrptional regulator BudR, which is responsible for activation of the expression of the butanediol operon genes; contains the type 2 periplasmic binding fold; Region: PBP2_BudR; cd08451
405416009718	putative dimerization interface [polypeptide binding]; other site
405416009719	putative substrate binding pocket [chemical binding]; other site
405416009720	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
405416009721	Major Facilitator Superfamily; Region: MFS_1; pfam07690
405416009722	putative substrate translocation pore; other site
405416009723	Major Facilitator Superfamily; Region: MFS_1; pfam07690
405416009724	Uncharacterized conserved protein [Function unknown]; Region: COG3791
405416009725	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
405416009726	S-adenosylmethionine binding site [chemical binding]; other site
405416009727	Predicted NAD/FAD-binding protein [General function prediction only]; Region: COG2907
405416009728	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
405416009729	Pirin-related protein [General function prediction only]; Region: COG1741
405416009730	Pirin; Region: Pirin; pfam02678
405416009731	Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726
405416009732	Isochorismatase family; Region: Isochorismatase; pfam00857
405416009733	YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012
405416009734	catalytic triad [active]
405416009735	dimer interface [polypeptide binding]; other site
405416009736	conserved cis-peptide bond; other site
405416009737	LysR family transcriptional regulator; Provisional; Region: PRK14997
405416009738	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
405416009739	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
405416009740	dimerization interface [polypeptide binding]; other site
405416009741	succinic semialdehyde dehydrogenase; Region: PLN02278
405416009742	Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103
405416009743	tetramerization interface [polypeptide binding]; other site
405416009744	NAD(P) binding site [chemical binding]; other site
405416009745	catalytic residues [active]
405416009746	4-aminobutyrate aminotransferase; Provisional; Region: PRK06777
405416009747	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
405416009748	inhibitor-cofactor binding pocket; inhibition site
405416009749	pyridoxal 5'-phosphate binding site [chemical binding]; other site
405416009750	catalytic residue [active]
405416009751	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
405416009752	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
405416009753	DNA-binding site [nucleotide binding]; DNA binding site
405416009754	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
405416009755	pyridoxal 5'-phosphate binding site [chemical binding]; other site
405416009756	homodimer interface [polypeptide binding]; other site
405416009757	catalytic residue [active]
405416009758	gamma-aminobutyrate permease; Region: GABAperm; TIGR01773
405416009759	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
405416009760	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
405416009761	non-specific DNA binding site [nucleotide binding]; other site
405416009762	salt bridge; other site
405416009763	sequence-specific DNA binding site [nucleotide binding]; other site
405416009764	Cupin domain; Region: Cupin_2; pfam07883
405416009765	AzlC protein; Region: AzlC; cl00570
405416009766	Branched-chain amino acid transport protein (AzlD); Region: AzlD; pfam05437
405416009767	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
405416009768	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
405416009769	dimer interface [polypeptide binding]; other site
405416009770	ssDNA binding site [nucleotide binding]; other site
405416009771	tetramer (dimer of dimers) interface [polypeptide binding]; other site
405416009772	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
405416009773	Major Facilitator Superfamily; Region: MFS_1; pfam07690
405416009774	putative substrate translocation pore; other site
405416009775	hypothetical protein; Provisional; Region: PRK14013
405416009776	Putative transcription activator [Transcription]; Region: TenA; COG0819
405416009777	GlpM protein; Region: GlpM; pfam06942
405416009778	Protein of unknown function (DUF1304); Region: DUF1304; pfam06993
405416009779	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
405416009780	2-enoyl thioester reductase (ETR) like proteins, child 2; Region: ETR_like_2; cd08292
405416009781	putative NAD(P) binding site [chemical binding]; other site
405416009782	putative dimer interface [polypeptide binding]; other site
405416009783	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
405416009784	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
405416009785	excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349
405416009786	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
405416009787	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
405416009788	ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271
405416009789	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
405416009790	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
405416009791	metal binding site [ion binding]; metal-binding site
405416009792	active site
405416009793	I-site; other site
405416009794	BCCT family transporter; Region: BCCT; pfam02028
405416009795	Predicted symporter [General function prediction only]; Region: DhlC; COG4147
405416009796	Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480
405416009797	Na binding site [ion binding]; other site
405416009798	Protein of unknown function, DUF485; Region: DUF485; pfam04341
405416009799	Na+/proline symporter [Amino acid transport and metabolism / General function prediction only]; Region: PutP; COG0591
405416009800	Na binding site [ion binding]; other site
405416009801	PAS fold; Region: PAS_7; pfam12860
405416009802	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
405416009803	putative active site [active]
405416009804	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
405416009805	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
405416009806	dimer interface [polypeptide binding]; other site
405416009807	phosphorylation site [posttranslational modification]
405416009808	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
405416009809	ATP binding site [chemical binding]; other site
405416009810	Mg2+ binding site [ion binding]; other site
405416009811	G-X-G motif; other site
405416009812	Response regulator receiver domain; Region: Response_reg; pfam00072
405416009813	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
405416009814	active site
405416009815	phosphorylation site [posttranslational modification]
405416009816	intermolecular recognition site; other site
405416009817	dimerization interface [polypeptide binding]; other site
405416009818	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
405416009819	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
405416009820	active site
405416009821	phosphorylation site [posttranslational modification]
405416009822	intermolecular recognition site; other site
405416009823	dimerization interface [polypeptide binding]; other site
405416009824	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
405416009825	DNA binding residues [nucleotide binding]
405416009826	dimerization interface [polypeptide binding]; other site
405416009827	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
405416009828	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
405416009829	dimethyl sulfone monooxygenase SfnG; Region: LLM_DMSO2_sfnG; TIGR04021
405416009830	Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094
405416009831	active site
405416009832	dimer interface [polypeptide binding]; other site
405416009833	non-prolyl cis peptide bond; other site
405416009834	insertion regions; other site
405416009835	helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344
405416009836	AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404
405416009837	dimerization interface [polypeptide binding]; other site
405416009838	putative DNA binding site [nucleotide binding]; other site
405416009839	putative Zn2+ binding site [ion binding]; other site
405416009840	AsnC family; Region: AsnC_trans_reg; pfam01037
405416009841	Isochorismatase family; Region: Isochorismatase; pfam00857
405416009842	Nicotinamidase_ related amidohydrolases.  Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014
405416009843	catalytic triad [active]
405416009844	conserved cis-peptide bond; other site
405416009845	Peroxidase, family 2; Region: Peroxidase_2; pfam01328
405416009846	acetyl-CoA synthetase; Provisional; Region: PRK00174
405416009847	Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966
405416009848	active site
405416009849	CoA binding site [chemical binding]; other site
405416009850	acyl-activating enzyme (AAE) consensus motif; other site
405416009851	AMP binding site [chemical binding]; other site
405416009852	acetate binding site [chemical binding]; other site
405416009853	Protein of unknown function (DUF805); Region: DUF805; pfam05656
405416009854	Fucose 4-O-acetylase and related acetyltransferases [Carbohydrate transport and metabolism]; Region: NolL; COG3594
405416009855	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
405416009856	Mechanosensitive ion channel; Region: MS_channel; pfam00924
405416009857	16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713
405416009858	3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749
405416009859	3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413
405416009860	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
405416009861	Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933
405416009862	FMN binding site [chemical binding]; other site
405416009863	active site
405416009864	substrate binding site [chemical binding]; other site
405416009865	catalytic residue [active]
405416009866	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
405416009867	putative DNA binding site [nucleotide binding]; other site
405416009868	dimerization interface [polypeptide binding]; other site
405416009869	putative Zn2+ binding site [ion binding]; other site
405416009870	peptide chain release factor 2; Provisional; Region: PRK08787
405416009871	This domain is found in peptide chain release factors; Region: PCRF; smart00937
405416009872	RF-1 domain; Region: RF-1; pfam00472
405416009873	ssDNA exonuclease RecJ; Provisional; Region: PRK11070
405416009874	DHH family; Region: DHH; pfam01368
405416009875	DHHA1 domain; Region: DHHA1; pfam02272
405416009876	pyridoxamine-phosphate oxidase; Region: pdxH; TIGR00558
405416009877	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243
405416009878	Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590
405416009879	phosphoglucosamine mutase; Provisional; Region: glmM; PRK10887
405416009880	GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802
405416009881	active site
405416009882	substrate binding site [chemical binding]; other site
405416009883	metal binding site [ion binding]; metal-binding site
405416009884	inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567
405416009885	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
405416009886	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein.  IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601
405416009887	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
405416009888	active site
405416009889	Predicted Fe-S-cluster oxidoreductase [General function prediction only]; Region: COG0727
405416009890	Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426
405416009891	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
405416009892	ferrichrome outer membrane transporter; Provisional; Region: PRK10044
405416009893	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
405416009894	N-terminal plug; other site
405416009895	ligand-binding site [chemical binding]; other site
405416009896	Predicted membrane protein [Function unknown]; Region: COG2119
405416009897	Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169
405416009898	Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169
405416009899	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
405416009900	pyruvate dehydrogenase dihydrolipoyltransacetylase; Validated; Region: aceF; PRK11854
405416009901	E3 interaction surface; other site
405416009902	lipoyl attachment site [posttranslational modification]; other site
405416009903	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
405416009904	E3 interaction surface; other site
405416009905	lipoyl attachment site [posttranslational modification]; other site
405416009906	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
405416009907	E3 interaction surface; other site
405416009908	lipoyl attachment site [posttranslational modification]; other site
405416009909	e3 binding domain; Region: E3_binding; pfam02817
405416009910	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
405416009911	pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405
405416009912	Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017
405416009913	dimer interface [polypeptide binding]; other site
405416009914	TPP-binding site [chemical binding]; other site
405416009915	Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410
405416009916	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
405416009917	Peptidase family M23; Region: Peptidase_M23; pfam01551
405416009918	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186
405416009919	UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331
405416009920	cell division protein FtsZ; Validated; Region: PRK09330
405416009921	FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes.  FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201
405416009922	nucleotide binding site [chemical binding]; other site
405416009923	SulA interaction site; other site
405416009924	Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849
405416009925	Cell division protein FtsA; Region: FtsA; smart00842
405416009926	Cell division protein FtsA; Region: FtsA; pfam14450
405416009927	POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478
405416009928	Cell division protein FtsQ; Region: FtsQ; pfam03799
405416009929	D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372
405416009930	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
405416009931	ATP-grasp domain; Region: ATP-grasp_4; cl17255
405416009932	UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421
405416009933	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
405416009934	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
405416009935	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
405416009936	undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726
405416009937	MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785
405416009938	active site
405416009939	homodimer interface [polypeptide binding]; other site
405416009940	glutathione synthetase; Provisional; Region: PRK05246
405416009941	Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951
405416009942	Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955
405416009943	Domain of unknown function (DUF1737); Region: DUF1737; pfam08410
405416009944	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
405416009945	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
405416009946	N-terminal plug; other site
405416009947	ligand-binding site [chemical binding]; other site
405416009948	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
405416009949	active site
405416009950	Neisseria meningitides Nape-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Nape_like_AP-endo; cd10281
405416009951	putative active site [active]
405416009952	putative catalytic site [active]
405416009953	putative DNA binding site [nucleotide binding]; other site
405416009954	putative phosphate binding site [ion binding]; other site
405416009955	metal binding site A [ion binding]; metal-binding site
405416009956	putative AP binding site [nucleotide binding]; other site
405416009957	putative metal binding site B [ion binding]; other site
405416009958	Arsenate Reductase (ArsC) family, Yffb subfamily; Yffb is an uncharacterized bacterial protein encoded by the yffb gene, related to the thioredoxin-fold arsenic reductases, ArsC. The structure of Yffb and the conservation of the catalytic cysteine...; Region: ArsC_Yffb; cd03035
405416009959	ArsC family; Region: ArsC; pfam03960
405416009960	putative catalytic residues [active]
405416009961	Uncharacterized protein conserved in bacteria (DUF2147); Region: DUF2147; pfam09917
405416009962	Protein of unknown function (DUF2424); Region: DUF2424; pfam10340
405416009963	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
405416009964	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
405416009965	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
405416009966	metal binding site [ion binding]; metal-binding site
405416009967	active site
405416009968	I-site; other site
405416009969	thiol:disulfide interchange protein precursor; Provisional; Region: dipZ; PRK00293
405416009970	Disulphide bond corrector protein DsbC; Region: DsbC; pfam11412
405416009971	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788
405416009972	DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953
405416009973	DsbD alpha interface [polypeptide binding]; other site
405416009974	catalytic residues [active]
405416009975	Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; pfam13557
405416009976	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
405416009977	Ankyrin repeats (many copies); Region: Ank_5; pfam13857
405416009978	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cl00250
405416009979	30S subunit binding site; other site
405416009980	putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212
405416009981	Catalytic domain of bacterial PuuE allantoinases, Schizosaccharomyces pombe chitin deacetylase 1 (SpCDA1), and similar proteins; Region: CE4_PuuE_SpCDA1; cd10977
405416009982	active site
405416009983	catalytic site [active]
405416009984	tetramer interface [polypeptide binding]; other site
405416009985	putative OHCU decarboxylase; Provisional; Region: PRK13798
405416009986	HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822
405416009987	active site
405416009988	homotetramer interface [polypeptide binding]; other site
405416009989	xanthine permease; Region: pbuX; TIGR03173
405416009990	Nucleoside-specific channel-forming protein, Tsx; Region: Channel_Tsx; cl04114
405416009991	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
405416009992	FAD binding domain; Region: FAD_binding_3; pfam01494
405416009993	allantoicase; Region: allantoicase; TIGR02961
405416009994	Allantoicase repeat; Region: Allantoicase; pfam03561
405416009995	Allantoicase repeat; Region: Allantoicase; pfam03561
405416009996	ureidoglycolate hydrolase; Provisional; Region: PRK03606
405416009997	Ureidoglycolate hydrolase [Nucleotide transport and metabolism]; Region: DAL3; COG3194
405416009998	DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559
405416009999	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
405416010000	ATP binding site [chemical binding]; other site
405416010001	Mg2+ binding site [ion binding]; other site
405416010002	G-X-G motif; other site
405416010003	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
405416010004	anchoring element; other site
405416010005	dimer interface [polypeptide binding]; other site
405416010006	ATP binding site [chemical binding]; other site
405416010007	Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718
405416010008	active site
405416010009	metal binding site [ion binding]; metal-binding site
405416010010	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
405416010011	Uncharacterized protein family (UPF0227); Region: UPF0227; cl14886
405416010012	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
405416010013	PGAP1-like protein; Region: PGAP1; pfam07819
405416010014	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
405416010015	Bacterial SH3 domain; Region: SH3_3; cl17532
405416010016	Protein of unknown function (DUF1311); Region: DUF1311; pfam07007
405416010017	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
405416010018	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
405416010019	lysozyme_like domain.  This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222
405416010020	CHAP domain; Region: CHAP; cl17642
405416010021	Uncharacterized protein conserved in bacteria [Function unknown]; Region: VgrG; COG3501
405416010022	Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954
405416010023	Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717
405416010024	Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296
405416010025	Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; pfam10106
405416010026	Disulfide bond formation protein DsbB; Region: DsbB; pfam02600
405416010027	Glutamate-cysteine ligase; Region: Glu_cys_ligase; cl17352
405416010028	Bacterial protein of unknown function (DUF924); Region: DUF924; pfam06041
405416010029	Protein of unknown function (DUF445); Region: DUF445; pfam04286
405416010030	methionine aminotransferase; Validated; Region: PRK09082
405416010031	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
405416010032	pyridoxal 5'-phosphate binding site [chemical binding]; other site
405416010033	homodimer interface [polypeptide binding]; other site
405416010034	catalytic residue [active]
405416010035	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
405416010036	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138
405416010037	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
405416010038	short chain dehydrogenase; Provisional; Region: PRK07832
405416010039	NAD(P) binding site [chemical binding]; other site
405416010040	active site
405416010041	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
405416010042	phosphate regulon transcriptional regulatory protein PhoB; Region: PhoB; TIGR02154
405416010043	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
405416010044	active site
405416010045	phosphorylation site [posttranslational modification]
405416010046	intermolecular recognition site; other site
405416010047	dimerization interface [polypeptide binding]; other site
405416010048	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
405416010049	DNA binding site [nucleotide binding]
405416010050	Domain of unknown function (DUF3329); Region: DUF3329; pfam11808
405416010051	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
405416010052	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
405416010053	putative active site [active]
405416010054	heme pocket [chemical binding]; other site
405416010055	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
405416010056	dimer interface [polypeptide binding]; other site
405416010057	phosphorylation site [posttranslational modification]
405416010058	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
405416010059	ATP binding site [chemical binding]; other site
405416010060	Mg2+ binding site [ion binding]; other site
405416010061	G-X-G motif; other site
405416010062	Secretory lipase; Region: LIP; pfam03583
405416010063	alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561
405416010064	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
405416010065	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
405416010066	Predicted acetamidase/formamidase [Energy production and conversion]; Region: COG2421
405416010067	phosphatidylserine decarboxylase; Reviewed; Region: psd; PRK00044
405416010068	Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897
405416010069	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
405416010070	active site residue [active]
405416010071	Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449
405416010072	active site residue [active]
405416010073	nicotinate phosphoribosyltransferase; Region: NAPRTase; TIGR01514
405416010074	Nicotinate phosphoribosyltransferase (NAPRTase), related to PncB. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting; Region: PncB_like; cd01401
405416010075	active site
405416010076	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
405416010077	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
405416010078	Clade 1 of the heme-binding enzyme catalase; Region: catalase_clade_1; cd08154
405416010079	Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753
405416010080	tetramer interface [polypeptide binding]; other site
405416010081	heme binding pocket [chemical binding]; other site
405416010082	D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563
405416010083	putative active site [active]
405416010084	dimerization interface [polypeptide binding]; other site
405416010085	putative tRNAtyr binding site [nucleotide binding]; other site
405416010086	CT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_1; cd04870
405416010087	ACT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_2; cd04871
405416010088	phosphoserine phosphatase SerB; Region: serB; TIGR00338
405416010089	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
405416010090	motif II; other site
405416010091	Domain of unknown function (DUF4175); Region: DUF4175; pfam13779
405416010092	bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II-like protein; Provisional; Region: PRK14019
405416010093	3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926
405416010094	GTP cyclohydrolase II; Region: GTP_cyclohydro2; pfam00925
405416010095	dimerization interface [polypeptide binding]; other site
405416010096	active site
405416010097	lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209
405416010098	homopentamer interface [polypeptide binding]; other site
405416010099	active site
405416010100	transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202
405416010101	thiamine monophosphate kinase; Provisional; Region: PRK05731
405416010102	ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194
405416010103	ATP binding site [chemical binding]; other site
405416010104	dimerization interface [polypeptide binding]; other site
405416010105	Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971
405416010106	tetramer interfaces [polypeptide binding]; other site
405416010107	binuclear metal-binding site [ion binding]; other site
405416010108	N-acetylglucosamine-1-phosphate uridyltransferase (contains nucleotidyltransferase and I-patch acetyltransferase domains) [Cell envelope biogenesis, outer membrane]; Region: GlmU; COG1207
405416010109	N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540
405416010110	Substrate binding site; other site
405416010111	Mg++ binding site; other site
405416010112	N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353
405416010113	active site
405416010114	substrate binding site [chemical binding]; other site
405416010115	CoA binding site [chemical binding]; other site
405416010116	glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331
405416010117	Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans).  The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714
405416010118	glutaminase active site [active]
405416010119	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
405416010120	dimer interface [polypeptide binding]; other site
405416010121	active site
405416010122	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
405416010123	dimer interface [polypeptide binding]; other site
405416010124	active site
405416010125	glutamate racemase; Provisional; Region: PRK00865
405416010126	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
405416010127	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
405416010128	motif I; other site
405416010129	active site
405416010130	Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960
405416010131	agmatinase; Region: agmatinase; TIGR01230
405416010132	Formimidoylglutamase or HutE; Region: Formimidoylglutamase; cd09988
405416010133	putative active site [active]
405416010134	putative metal binding site [ion binding]; other site
405416010135	imidazolonepropionase; Validated; Region: PRK09356
405416010136	Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296
405416010137	active site
405416010138	putative proline-specific permease; Provisional; Region: proY; PRK10580
405416010139	Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332
405416010140	active sites [active]
405416010141	tetramer interface [polypeptide binding]; other site
405416010142	urocanate hydratase; Provisional; Region: PRK05414
405416010143	HutD; Region: HutD; pfam05962
405416010144	histidine utilization repressor, proteobacterial; Region: his_ut_repres; TIGR02018
405416010145	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
405416010146	DNA-binding site [nucleotide binding]; DNA binding site
405416010147	UTRA domain; Region: UTRA; pfam07702
405416010148	Acyltransferase family; Region: Acyl_transf_3; pfam01757
405416010149	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
405416010150	CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492
405416010151	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833
405416010152	Peptidase M15; Region: Peptidase_M15_3; cl01194
405416010153	aromatic amino acid transporter; Provisional; Region: PRK10238
405416010154	fumarylacetoacetase; Region: PLN02856
405416010155	Domain of unknown function (DUF1969); Region: DUF1969; pfam09298
405416010156	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
405416010157	GST_N family, Class Zeta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Zeta; cd03042
405416010158	maleylacetoacetate isomerase; Region: maiA; TIGR01262
405416010159	C-terminal domain interface [polypeptide binding]; other site
405416010160	GSH binding site (G-site) [chemical binding]; other site
405416010161	putative dimer interface [polypeptide binding]; other site
405416010162	C-terminal, alpha helical domain of Class Zeta Glutathione S-transferases; Region: GST_C_Zeta; cd03191
405416010163	dimer interface [polypeptide binding]; other site
405416010164	N-terminal domain interface [polypeptide binding]; other site
405416010165	maleylacetoacetate (MAA) substrate binding site (H site) [chemical binding]; other site
405416010166	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
405416010167	N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346
405416010168	Zn binding site [ion binding]; other site
405416010169	IclR helix-turn-helix domain; Region: HTH_IclR; cl17605
405416010170	Transcriptional regulator [Transcription]; Region: IclR; COG1414
405416010171	Bacterial transcriptional regulator; Region: IclR; pfam01614
405416010172	4-hydroxyphenylpyruvate dioxygenase and related hemolysins [Amino acid transport and metabolism / General function prediction only]; Region: COG3185
405416010173	N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342
405416010174	dimer interface [polypeptide binding]; other site
405416010175	C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250
405416010176	active site
405416010177	Fe binding site [ion binding]; other site
405416010178	Uncharacterized conserved protein [Function unknown]; Region: COG1683
405416010179	putative efflux protein, MATE family; Region: matE; TIGR00797
405416010180	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
405416010181	Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385
405416010182	Sodium Bile acid symporter family; Region: SBF; pfam01758
405416010183	Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011
405416010184	Isochorismatase family; Region: Isochorismatase; pfam00857
405416010185	catalytic triad [active]
405416010186	metal binding site [ion binding]; metal-binding site
405416010187	conserved cis-peptide bond; other site
405416010188	Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
405416010189	dihydrodipicolinate synthase; Region: dapA; TIGR00674
405416010190	dimer interface [polypeptide binding]; other site
405416010191	active site
405416010192	catalytic residue [active]
405416010193	phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362
405416010194	bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415
405416010195	ATP binding site [chemical binding]; other site
405416010196	active site
405416010197	substrate binding site [chemical binding]; other site
405416010198	Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226
405416010199	recombination factor protein RarA; Reviewed; Region: PRK13342
405416010200	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
405416010201	Walker A motif; other site
405416010202	ATP binding site [chemical binding]; other site
405416010203	Walker B motif; other site
405416010204	arginine finger; other site
405416010205	MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002
405416010206	Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995
405416010207	dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606
405416010208	hypothetical protein; Provisional; Region: PRK05170
405416010209	Small integral membrane protein [Function unknown]; Region: COG5487; cl17674
405416010210	Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412
405416010211	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
405416010212	Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537
405416010213	nucleotide binding site/active site [active]
405416010214	HIT family signature motif; other site
405416010215	catalytic residue [active]
405416010216	A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194
405416010217	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
405416010218	minor groove reading motif; other site
405416010219	helix-hairpin-helix signature motif; other site
405416010220	substrate binding pocket [chemical binding]; other site
405416010221	active site
405416010222	iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525
405416010223	DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread  A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431
405416010224	DNA binding and oxoG recognition site [nucleotide binding]
405416010225	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
405416010226	Peptidase family M23; Region: Peptidase_M23; pfam01551
405416010227	Methyladenine glycosylase; Region: Adenine_glyco; pfam03352
405416010228	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
405416010229	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283
405416010230	putative NAD(P) binding site [chemical binding]; other site
405416010231	putative substrate binding site [chemical binding]; other site
405416010232	catalytic Zn binding site [ion binding]; other site
405416010233	structural Zn binding site [ion binding]; other site
405416010234	dimer interface [polypeptide binding]; other site
405416010235	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
405416010236	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
405416010237	DNA-binding site [nucleotide binding]; DNA binding site
405416010238	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
405416010239	pyridoxal 5'-phosphate binding site [chemical binding]; other site
405416010240	homodimer interface [polypeptide binding]; other site
405416010241	catalytic residue [active]
405416010242	membrane-bound lytic murein transglycosylase D; Provisional; Region: mltD; PRK10783
405416010243	Transcriptional regulator [Transcription]; Region: LysR; COG0583
405416010244	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
405416010245	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA; cd08478
405416010246	putative effector binding pocket; other site
405416010247	dimerization interface [polypeptide binding]; other site
405416010248	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
405416010249	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
405416010250	active site
405416010251	catalytic tetrad [active]
405416010252	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
405416010253	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
405416010254	putative substrate translocation pore; other site
405416010255	Uncharacterized subgroup of the steroidogenic acute regulatory protein (StAR)-related lipid transfer (START) domain family; Region: START_1; cd08876
405416010256	putative lipid binding site [chemical binding]; other site
405416010257	dihydrodipicolinate reductase; Provisional; Region: PRK00048
405416010258	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
405416010259	Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173
405416010260	chaperone protein DnaJ; Provisional; Region: PRK10767
405416010261	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
405416010262	HSP70 interaction site [polypeptide binding]; other site
405416010263	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262
405416010264	substrate binding site [polypeptide binding]; other site
405416010265	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
405416010266	Zn binding sites [ion binding]; other site
405416010267	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
405416010268	dimer interface [polypeptide binding]; other site
405416010269	Inorganic H+ pyrophosphatase; Region: H_PPase; pfam03030
405416010270	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
405416010271	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
405416010272	HlyD family secretion protein; Region: HlyD_3; pfam13437
405416010273	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
405416010274	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
405416010275	AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246
405416010276	phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009
405416010277	Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352
405416010278	pyrimidine utilization transport protein G; Region: RutG; TIGR03616
405416010279	Transcriptional regulator [Transcription]; Region: LysR; COG0583
405416010280	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
405416010281	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
405416010282	dimerization interface [polypeptide binding]; other site
405416010283	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
405416010284	dihydroxy-acid dehydratase; Provisional; Region: PRK12448
405416010285	methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005
405416010286	Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646
405416010287	putative active site [active]
405416010288	substrate binding site [chemical binding]; other site
405416010289	putative cosubstrate binding site; other site
405416010290	catalytic site [active]
405416010291	C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704
405416010292	substrate binding site [chemical binding]; other site
405416010293	16S rRNA methyltransferase B; Provisional; Region: PRK10901
405416010294	NusB family; Region: NusB; pfam01029
405416010295	putative RNA binding site [nucleotide binding]; other site
405416010296	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
405416010297	S-adenosylmethionine binding site [chemical binding]; other site
405416010298	uncharacterized bacterial and archaeal solute carrier 6 subfamily; solute-binding domain; Region: SLC6sbd_u1; cd10334
405416010299	Na2 binding site [ion binding]; other site
405416010300	putative substrate binding site 1 [chemical binding]; other site
405416010301	Na binding site 1 [ion binding]; other site
405416010302	putative substrate binding site 2 [chemical binding]; other site
405416010303	outer membrane protein; Region: OMP_w_GlyGly; TIGR04219
405416010304	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
405416010305	GST_N family, unknown subfamily 4; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_4; cd03056
405416010306	putative C-terminal domain interface [polypeptide binding]; other site
405416010307	putative GSH binding site (G-site) [chemical binding]; other site
405416010308	putative dimer interface [polypeptide binding]; other site
405416010309	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776
405416010310	dimer interface [polypeptide binding]; other site
405416010311	N-terminal domain interface [polypeptide binding]; other site
405416010312	substrate binding pocket (H-site) [chemical binding]; other site
405416010313	tyrosyl-tRNA synthetase; Validated; Region: PRK05912
405416010314	catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805
405416010315	active site
405416010316	HIGH motif; other site
405416010317	dimer interface [polypeptide binding]; other site
405416010318	KMSKS motif; other site
405416010319	anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585
405416010320	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
405416010321	iron-sulfur cluster insertion protein ErpA; Provisional; Region: PRK13623
405416010322	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
405416010323	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
405416010324	putative ABC transporter ATP-binding protein; Provisional; Region: PRK10636
405416010325	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
405416010326	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
405416010327	ABC transporter; Region: ABC_tran_2; pfam12848
405416010328	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
405416010329	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
405416010330	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586