-- dump date   	20140618_190531
-- class       	Genbank::misc_feature
-- table       	misc_feature_note
-- id	note
889738000001	DnaA N-terminal domain; Region: DnaA_N; pfam11638
889738000002	chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362
889738000003	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
889738000004	Walker A motif; other site
889738000005	ATP binding site [chemical binding]; other site
889738000006	Walker B motif; other site
889738000007	arginine finger; other site
889738000008	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
889738000009	DnaA box-binding interface [nucleotide binding]; other site
889738000010	DNA polymerase III subunit beta; Validated; Region: PRK05643
889738000011	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
889738000012	putative DNA binding surface [nucleotide binding]; other site
889738000013	dimer interface [polypeptide binding]; other site
889738000014	beta-clamp/clamp loader binding surface; other site
889738000015	beta-clamp/translesion DNA polymerase binding surface; other site
889738000016	recombination protein F; Reviewed; Region: recF; PRK00064
889738000017	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
889738000018	Walker A/P-loop; other site
889738000019	ATP binding site [chemical binding]; other site
889738000020	Q-loop/lid; other site
889738000021	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
889738000022	ABC transporter signature motif; other site
889738000023	Walker B; other site
889738000024	D-loop; other site
889738000025	H-loop/switch region; other site
889738000026	DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939
889738000027	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
889738000028	ATP binding site [chemical binding]; other site
889738000029	Mg2+ binding site [ion binding]; other site
889738000030	G-X-G motif; other site
889738000031	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
889738000032	anchoring element; other site
889738000033	dimer interface [polypeptide binding]; other site
889738000034	ATP binding site [chemical binding]; other site
889738000035	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
889738000036	active site
889738000037	putative metal-binding site [ion binding]; other site
889738000038	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
889738000039	Cytochrome b562; Region: Cytochrom_B562; pfam07361
889738000040	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
889738000041	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
889738000042	putative ABC transporter ATP-binding protein; Provisional; Region: PRK10636
889738000043	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
889738000044	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
889738000045	ABC transporter; Region: ABC_tran_2; pfam12848
889738000046	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
889738000047	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
889738000048	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
889738000049	iron-sulfur cluster insertion protein ErpA; Provisional; Region: PRK13623
889738000050	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
889738000051	anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585
889738000052	tyrosyl-tRNA synthetase; Validated; Region: PRK05912
889738000053	catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805
889738000054	active site
889738000055	HIGH motif; other site
889738000056	dimer interface [polypeptide binding]; other site
889738000057	KMSKS motif; other site
889738000058	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
889738000059	GST_N family, unknown subfamily 4; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_4; cd03056
889738000060	putative C-terminal domain interface [polypeptide binding]; other site
889738000061	putative GSH binding site (G-site) [chemical binding]; other site
889738000062	putative dimer interface [polypeptide binding]; other site
889738000063	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776
889738000064	dimer interface [polypeptide binding]; other site
889738000065	N-terminal domain interface [polypeptide binding]; other site
889738000066	substrate binding pocket (H-site) [chemical binding]; other site
889738000067	outer membrane protein; Region: OMP_w_GlyGly; TIGR04219
889738000068	uncharacterized bacterial and archaeal solute carrier 6 subfamily; solute-binding domain; Region: SLC6sbd_u1; cd10334
889738000069	Na2 binding site [ion binding]; other site
889738000070	putative substrate binding site 1 [chemical binding]; other site
889738000071	Na binding site 1 [ion binding]; other site
889738000072	putative substrate binding site 2 [chemical binding]; other site
889738000073	16S rRNA methyltransferase B; Provisional; Region: PRK10901
889738000074	NusB family; Region: NusB; pfam01029
889738000075	putative RNA binding site [nucleotide binding]; other site
889738000076	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
889738000077	S-adenosylmethionine binding site [chemical binding]; other site
889738000078	methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005
889738000079	Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646
889738000080	putative active site [active]
889738000081	substrate binding site [chemical binding]; other site
889738000082	putative cosubstrate binding site; other site
889738000083	catalytic site [active]
889738000084	C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704
889738000085	substrate binding site [chemical binding]; other site
889738000086	dihydroxy-acid dehydratase; Provisional; Region: PRK12448
889738000087	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
889738000088	Transcriptional regulator [Transcription]; Region: LysR; COG0583
889738000089	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
889738000090	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
889738000091	dimerization interface [polypeptide binding]; other site
889738000092	pyrimidine utilization transport protein G; Region: RutG; TIGR03616
889738000093	phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009
889738000094	Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352
889738000095	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
889738000096	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
889738000097	AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246
889738000098	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
889738000099	HlyD family secretion protein; Region: HlyD_3; pfam13437
889738000100	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
889738000101	Inorganic H+ pyrophosphatase; Region: H_PPase; pfam03030
889738000102	chaperone protein DnaJ; Provisional; Region: PRK10767
889738000103	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
889738000104	HSP70 interaction site [polypeptide binding]; other site
889738000105	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262
889738000106	substrate binding site [polypeptide binding]; other site
889738000107	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
889738000108	Zn binding sites [ion binding]; other site
889738000109	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
889738000110	dimer interface [polypeptide binding]; other site
889738000111	dihydrodipicolinate reductase; Provisional; Region: PRK00048
889738000112	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
889738000113	Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173
889738000114	Uncharacterized subgroup of the steroidogenic acute regulatory protein (StAR)-related lipid transfer (START) domain family; Region: START_1; cd08876
889738000115	putative lipid binding site [chemical binding]; other site
889738000116	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
889738000117	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
889738000118	putative substrate translocation pore; other site
889738000119	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
889738000120	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
889738000121	active site
889738000122	catalytic tetrad [active]
889738000123	Transcriptional regulator [Transcription]; Region: LysR; COG0583
889738000124	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
889738000125	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA; cd08478
889738000126	putative effector binding pocket; other site
889738000127	dimerization interface [polypeptide binding]; other site
889738000128	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
889738000129	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
889738000130	DNA-binding site [nucleotide binding]; DNA binding site
889738000131	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
889738000132	pyridoxal 5'-phosphate binding site [chemical binding]; other site
889738000133	homodimer interface [polypeptide binding]; other site
889738000134	catalytic residue [active]
889738000135	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
889738000136	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283
889738000137	putative NAD(P) binding site [chemical binding]; other site
889738000138	putative substrate binding site [chemical binding]; other site
889738000139	catalytic Zn binding site [ion binding]; other site
889738000140	structural Zn binding site [ion binding]; other site
889738000141	dimer interface [polypeptide binding]; other site
889738000142	Methyladenine glycosylase; Region: Adenine_glyco; pfam03352
889738000143	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
889738000144	Peptidase family M23; Region: Peptidase_M23; pfam01551
889738000145	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
889738000146	endonuclease III; Region: ENDO3c; smart00478
889738000147	minor groove reading motif; other site
889738000148	helix-hairpin-helix signature motif; other site
889738000149	substrate binding pocket [chemical binding]; other site
889738000150	active site
889738000151	iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525
889738000152	Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537
889738000153	nucleotide binding site/active site [active]
889738000154	HIT family signature motif; other site
889738000155	catalytic residue [active]
889738000156	Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412
889738000157	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
889738000158	Small integral membrane protein [Function unknown]; Region: COG5487; cl17674
889738000159	hypothetical protein; Provisional; Region: PRK05170
889738000160	dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606
889738000161	Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995
889738000162	recombination factor protein RarA; Reviewed; Region: PRK13342
889738000163	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
889738000164	Walker A motif; other site
889738000165	ATP binding site [chemical binding]; other site
889738000166	Walker B motif; other site
889738000167	arginine finger; other site
889738000168	MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002
889738000169	Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226
889738000170	phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362
889738000171	bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415
889738000172	ATP binding site [chemical binding]; other site
889738000173	active site
889738000174	substrate binding site [chemical binding]; other site
889738000175	Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
889738000176	dihydrodipicolinate synthase; Region: dapA; TIGR00674
889738000177	dimer interface [polypeptide binding]; other site
889738000178	active site
889738000179	catalytic residue [active]
889738000180	Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011
889738000181	Isochorismatase family; Region: Isochorismatase; pfam00857
889738000182	catalytic triad [active]
889738000183	metal binding site [ion binding]; metal-binding site
889738000184	conserved cis-peptide bond; other site
889738000185	Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385
889738000186	Sodium Bile acid symporter family; Region: SBF; pfam01758
889738000187	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131
889738000188	putative efflux protein, MATE family; Region: matE; TIGR00797
889738000189	cation binding site [ion binding]; other site
889738000190	Uncharacterized conserved protein [Function unknown]; Region: COG1683
889738000191	4-hydroxyphenylpyruvate dioxygenase and related hemolysins [Amino acid transport and metabolism / General function prediction only]; Region: COG3185
889738000192	N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342
889738000193	dimer interface [polypeptide binding]; other site
889738000194	C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250
889738000195	active site
889738000196	Fe binding site [ion binding]; other site
889738000197	IclR helix-turn-helix domain; Region: HTH_IclR; cl17605
889738000198	Transcriptional regulator [Transcription]; Region: IclR; COG1414
889738000199	Bacterial transcriptional regulator; Region: IclR; pfam01614
889738000200	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
889738000201	N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346
889738000202	Zn binding site [ion binding]; other site
889738000203	GST_N family, Class Zeta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Zeta; cd03042
889738000204	maleylacetoacetate isomerase; Region: maiA; TIGR01262
889738000205	C-terminal domain interface [polypeptide binding]; other site
889738000206	GSH binding site (G-site) [chemical binding]; other site
889738000207	putative dimer interface [polypeptide binding]; other site
889738000208	C-terminal, alpha helical domain of Class Zeta Glutathione S-transferases; Region: GST_C_Zeta; cd03191
889738000209	dimer interface [polypeptide binding]; other site
889738000210	N-terminal domain interface [polypeptide binding]; other site
889738000211	maleylacetoacetate (MAA) substrate binding site (H site) [chemical binding]; other site
889738000212	fumarylacetoacetase; Region: PLN02856
889738000213	Domain of unknown function (DUF1969); Region: DUF1969; pfam09298
889738000214	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
889738000215	aromatic amino acid transporter; Provisional; Region: PRK10238
889738000216	Peptidase M15; Region: Peptidase_M15_3; cl01194
889738000217	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
889738000218	CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492
889738000219	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833
889738000220	Acyltransferase family; Region: Acyl_transf_3; pfam01757
889738000221	histidine utilization repressor, proteobacterial; Region: his_ut_repres; TIGR02018
889738000222	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
889738000223	DNA-binding site [nucleotide binding]; DNA binding site
889738000224	UTRA domain; Region: UTRA; pfam07702
889738000225	HutD; Region: HutD; pfam05962
889738000226	urocanate hydratase; Provisional; Region: PRK05414
889738000227	Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332
889738000228	active sites [active]
889738000229	tetramer interface [polypeptide binding]; other site
889738000230	putative proline-specific permease; Provisional; Region: proY; PRK10580
889738000231	imidazolonepropionase; Validated; Region: PRK09356
889738000232	Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296
889738000233	active site
889738000234	agmatinase; Region: agmatinase; TIGR01230
889738000235	Formimidoylglutamase or HutE; Region: Formimidoylglutamase; cd09988
889738000236	putative active site [active]
889738000237	putative metal binding site [ion binding]; other site
889738000238	Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960
889738000239	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
889738000240	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
889738000241	motif II; other site
889738000242	glutamate racemase; Provisional; Region: PRK00865
889738000243	glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331
889738000244	Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans).  The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714
889738000245	glutaminase active site [active]
889738000246	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
889738000247	dimer interface [polypeptide binding]; other site
889738000248	active site
889738000249	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
889738000250	dimer interface [polypeptide binding]; other site
889738000251	active site
889738000252	N-acetylglucosamine-1-phosphate uridyltransferase (contains nucleotidyltransferase and I-patch acetyltransferase domains) [Cell envelope biogenesis, outer membrane]; Region: GlmU; COG1207
889738000253	N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540
889738000254	Substrate binding site; other site
889738000255	Mg++ binding site; other site
889738000256	N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353
889738000257	active site
889738000258	substrate binding site [chemical binding]; other site
889738000259	CoA binding site [chemical binding]; other site
889738000260	Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971
889738000261	tetramer interfaces [polypeptide binding]; other site
889738000262	binuclear metal-binding site [ion binding]; other site
889738000263	thiamine monophosphate kinase; Provisional; Region: PRK05731
889738000264	ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194
889738000265	ATP binding site [chemical binding]; other site
889738000266	dimerization interface [polypeptide binding]; other site
889738000267	transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202
889738000268	lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209
889738000269	homopentamer interface [polypeptide binding]; other site
889738000270	active site
889738000271	bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II-like protein; Provisional; Region: PRK14019
889738000272	3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926
889738000273	GTP cyclohydrolase II; Region: GTP_cyclohydro2; pfam00925
889738000274	dimerization interface [polypeptide binding]; other site
889738000275	active site
889738000276	Domain of unknown function (DUF4175); Region: DUF4175; pfam13779
889738000277	CT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_1; cd04870
889738000278	ACT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_2; cd04871
889738000279	phosphoserine phosphatase SerB; Region: serB; TIGR00338
889738000280	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
889738000281	motif II; other site
889738000282	D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563
889738000283	putative active site [active]
889738000284	dimerization interface [polypeptide binding]; other site
889738000285	putative tRNAtyr binding site [nucleotide binding]; other site
889738000286	nicotinate phosphoribosyltransferase; Region: NAPRTase; TIGR01514
889738000287	Nicotinate phosphoribosyltransferase (NAPRTase), related to PncB. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting; Region: PncB_like; cd01401
889738000288	active site
889738000289	Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897
889738000290	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
889738000291	active site residue [active]
889738000292	Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449
889738000293	active site residue [active]
889738000294	phosphatidylserine decarboxylase; Reviewed; Region: psd; PRK00044
889738000295	Predicted acetamidase/formamidase [Energy production and conversion]; Region: COG2421
889738000296	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
889738000297	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
889738000298	Secretory lipase; Region: LIP; pfam03583
889738000299	alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561
889738000300	Domain of unknown function (DUF3329); Region: DUF3329; pfam11808
889738000301	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
889738000302	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
889738000303	putative active site [active]
889738000304	heme pocket [chemical binding]; other site
889738000305	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
889738000306	dimer interface [polypeptide binding]; other site
889738000307	phosphorylation site [posttranslational modification]
889738000308	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
889738000309	ATP binding site [chemical binding]; other site
889738000310	Mg2+ binding site [ion binding]; other site
889738000311	G-X-G motif; other site
889738000312	phosphate regulon transcriptional regulatory protein PhoB; Region: PhoB; TIGR02154
889738000313	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
889738000314	active site
889738000315	phosphorylation site [posttranslational modification]
889738000316	intermolecular recognition site; other site
889738000317	dimerization interface [polypeptide binding]; other site
889738000318	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
889738000319	DNA binding site [nucleotide binding]
889738000320	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
889738000321	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
889738000322	short chain dehydrogenase; Provisional; Region: PRK07832
889738000323	NAD(P) binding site [chemical binding]; other site
889738000324	active site
889738000325	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
889738000326	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138
889738000327	methionine aminotransferase; Validated; Region: PRK09082
889738000328	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
889738000329	pyridoxal 5'-phosphate binding site [chemical binding]; other site
889738000330	homodimer interface [polypeptide binding]; other site
889738000331	catalytic residue [active]
889738000332	Protein of unknown function (DUF445); Region: DUF445; pfam04286
889738000333	Bacterial protein of unknown function (DUF924); Region: DUF924; pfam06041
889738000334	Glutamate-cysteine ligase; Region: Glu_cys_ligase; cl17352
889738000335	Disulfide bond formation protein DsbB; Region: DsbB; pfam02600
889738000336	Uncharacterized protein conserved in bacteria [Function unknown]; Region: VgrG; COG3501
889738000337	Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954
889738000338	Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717
889738000339	Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296
889738000340	Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; pfam10106
889738000341	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
889738000342	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
889738000343	Peptidase family M23; Region: Peptidase_M23; pfam01551
889738000344	PGAP1-like protein; Region: PGAP1; pfam07819
889738000345	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
889738000346	Uncharacterized protein family (UPF0227); Region: UPF0227; cl14886
889738000347	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
889738000348	DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559
889738000349	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
889738000350	ATP binding site [chemical binding]; other site
889738000351	Mg2+ binding site [ion binding]; other site
889738000352	G-X-G motif; other site
889738000353	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
889738000354	anchoring element; other site
889738000355	dimer interface [polypeptide binding]; other site
889738000356	ATP binding site [chemical binding]; other site
889738000357	Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718
889738000358	active site
889738000359	metal binding site [ion binding]; metal-binding site
889738000360	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
889738000361	3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830
889738000362	classical (c) SDRs; Region: SDR_c; cd05233
889738000363	NAD(P) binding site [chemical binding]; other site
889738000364	active site
889738000365	ureidoglycolate hydrolase; Provisional; Region: PRK03606
889738000366	Ureidoglycolate hydrolase [Nucleotide transport and metabolism]; Region: DAL3; COG3194
889738000367	allantoicase; Provisional; Region: PRK13257
889738000368	Allantoicase repeat; Region: Allantoicase; pfam03561
889738000369	Allantoicase repeat; Region: Allantoicase; pfam03561
889738000370	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
889738000371	FAD binding domain; Region: FAD_binding_3; pfam01494
889738000372	Nucleoside-specific channel-forming protein, Tsx; Region: Channel_Tsx; cl04114
889738000373	xanthine permease; Region: pbuX; TIGR03173
889738000374	HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822
889738000375	active site
889738000376	homotetramer interface [polypeptide binding]; other site
889738000377	putative OHCU decarboxylase; Provisional; Region: PRK13798
889738000378	putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212
889738000379	Catalytic domain of bacterial PuuE allantoinases, Schizosaccharomyces pombe chitin deacetylase 1 (SpCDA1), and similar proteins; Region: CE4_PuuE_SpCDA1; cd10977
889738000380	active site
889738000381	catalytic site [active]
889738000382	tetramer interface [polypeptide binding]; other site
889738000383	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cl00250
889738000384	30S subunit binding site; other site
889738000385	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
889738000386	Ankyrin repeats (many copies); Region: Ank_5; pfam13857
889738000387	Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; pfam13557
889738000388	thiol:disulfide interchange protein precursor; Provisional; Region: dipZ; PRK00293
889738000389	Disulphide bond corrector protein DsbC; Region: DsbC; pfam11412
889738000390	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788
889738000391	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
889738000392	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
889738000393	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
889738000394	metal binding site [ion binding]; metal-binding site
889738000395	active site
889738000396	I-site; other site
889738000397	Protein of unknown function (DUF2424); Region: DUF2424; pfam10340
889738000398	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
889738000399	Uncharacterized protein conserved in bacteria (DUF2147); Region: DUF2147; pfam09917
889738000400	Arsenate Reductase (ArsC) family, Yffb subfamily; Yffb is an uncharacterized bacterial protein encoded by the yffb gene, related to the thioredoxin-fold arsenic reductases, ArsC. The structure of Yffb and the conservation of the catalytic cysteine...; Region: ArsC_Yffb; cd03035
889738000401	ArsC family; Region: ArsC; pfam03960
889738000402	putative catalytic residues [active]
889738000403	Neisseria meningitides Nape-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Nape_like_AP-endo; cd10281
889738000404	putative active site [active]
889738000405	putative catalytic site [active]
889738000406	putative DNA binding site [nucleotide binding]; other site
889738000407	putative phosphate binding site [ion binding]; other site
889738000408	metal binding site A [ion binding]; metal-binding site
889738000409	putative AP binding site [nucleotide binding]; other site
889738000410	putative metal binding site B [ion binding]; other site
889738000411	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
889738000412	active site
889738000413	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
889738000414	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
889738000415	N-terminal plug; other site
889738000416	ligand-binding site [chemical binding]; other site
889738000417	Domain of unknown function (DUF1737); Region: DUF1737; pfam08410
889738000418	glutathione synthetase; Provisional; Region: PRK05246
889738000419	Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951
889738000420	Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955
889738000421	undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726
889738000422	MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785
889738000423	active site
889738000424	homodimer interface [polypeptide binding]; other site
889738000425	UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421
889738000426	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
889738000427	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
889738000428	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
889738000429	D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372
889738000430	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
889738000431	ATP-grasp domain; Region: ATP-grasp_4; cl17255
889738000432	POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478
889738000433	Cell division protein FtsQ; Region: FtsQ; pfam03799
889738000434	Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849
889738000435	Cell division protein FtsA; Region: FtsA; smart00842
889738000436	Cell division protein FtsA; Region: FtsA; pfam14450
889738000437	cell division protein FtsZ; Validated; Region: PRK09330
889738000438	FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes.  FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201
889738000439	nucleotide binding site [chemical binding]; other site
889738000440	SulA interaction site; other site
889738000441	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186
889738000442	UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331
889738000443	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
889738000444	Peptidase family M23; Region: Peptidase_M23; pfam01551
889738000445	pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405
889738000446	Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017
889738000447	dimer interface [polypeptide binding]; other site
889738000448	TPP-binding site [chemical binding]; other site
889738000449	Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410
889738000450	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
889738000451	pyruvate dehydrogenase dihydrolipoyltransacetylase; Validated; Region: aceF; PRK11854
889738000452	E3 interaction surface; other site
889738000453	lipoyl attachment site [posttranslational modification]; other site
889738000454	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
889738000455	E3 interaction surface; other site
889738000456	lipoyl attachment site [posttranslational modification]; other site
889738000457	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
889738000458	E3 interaction surface; other site
889738000459	lipoyl attachment site [posttranslational modification]; other site
889738000460	e3 binding domain; Region: E3_binding; pfam02817
889738000461	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
889738000462	Predicted membrane protein [Function unknown]; Region: COG2119
889738000463	Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169
889738000464	Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169
889738000465	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
889738000466	ligand-binding site [chemical binding]; other site
889738000467	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
889738000468	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
889738000469	Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426
889738000470	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
889738000471	Predicted Fe-S-cluster oxidoreductase [General function prediction only]; Region: COG0727
889738000472	inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567
889738000473	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
889738000474	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein.  IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601
889738000475	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
889738000476	active site
889738000477	phosphoglucosamine mutase; Provisional; Region: glmM; PRK10887
889738000478	GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802
889738000479	active site
889738000480	substrate binding site [chemical binding]; other site
889738000481	metal binding site [ion binding]; metal-binding site
889738000482	pyridoxamine-phosphate oxidase; Region: pdxH; TIGR00558
889738000483	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243
889738000484	Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590
889738000485	ssDNA exonuclease RecJ; Provisional; Region: PRK11070
889738000486	DHH family; Region: DHH; pfam01368
889738000487	DHHA1 domain; Region: DHHA1; pfam02272
889738000488	peptide chain release factor 2; Provisional; Region: PRK08787
889738000489	This domain is found in peptide chain release factors; Region: PCRF; smart00937
889738000490	RF-1 domain; Region: RF-1; pfam00472
889738000491	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
889738000492	putative DNA binding site [nucleotide binding]; other site
889738000493	dimerization interface [polypeptide binding]; other site
889738000494	putative Zn2+ binding site [ion binding]; other site
889738000495	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
889738000496	Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933
889738000497	FMN binding site [chemical binding]; other site
889738000498	active site
889738000499	substrate binding site [chemical binding]; other site
889738000500	catalytic residue [active]
889738000501	3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749
889738000502	3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413
889738000503	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
889738000504	RNA methyltransferase, RsmE family; Region: TIGR00046
889738000505	16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713
889738000506	Fucose 4-O-acetylase and related acetyltransferases [Carbohydrate transport and metabolism]; Region: NolL; COG3594
889738000507	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
889738000508	Mechanosensitive ion channel; Region: MS_channel; pfam00924
889738000509	Protein of unknown function (DUF805); Region: DUF805; pfam05656
889738000510	acetyl-CoA synthetase; Provisional; Region: PRK00174
889738000511	Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966
889738000512	active site
889738000513	CoA binding site [chemical binding]; other site
889738000514	acyl-activating enzyme (AAE) consensus motif; other site
889738000515	AMP binding site [chemical binding]; other site
889738000516	acetate binding site [chemical binding]; other site
889738000517	Isochorismatase family; Region: Isochorismatase; pfam00857
889738000518	Nicotinamidase_ related amidohydrolases.  Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014
889738000519	catalytic triad [active]
889738000520	conserved cis-peptide bond; other site
889738000521	helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344
889738000522	AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404
889738000523	dimerization interface [polypeptide binding]; other site
889738000524	putative DNA binding site [nucleotide binding]; other site
889738000525	putative Zn2+ binding site [ion binding]; other site
889738000526	AsnC family; Region: AsnC_trans_reg; pfam01037
889738000527	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328
889738000528	MULE transposase domain; Region: MULE; pfam10551
889738000529	dimethyl sulfone monooxygenase SfnG; Region: LLM_DMSO2_sfnG; TIGR04021
889738000530	Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094
889738000531	active site
889738000532	dimer interface [polypeptide binding]; other site
889738000533	non-prolyl cis peptide bond; other site
889738000534	insertion regions; other site
889738000535	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
889738000536	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
889738000537	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
889738000538	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
889738000539	active site
889738000540	phosphorylation site [posttranslational modification]
889738000541	intermolecular recognition site; other site
889738000542	dimerization interface [polypeptide binding]; other site
889738000543	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
889738000544	DNA binding residues [nucleotide binding]
889738000545	dimerization interface [polypeptide binding]; other site
889738000546	Na+/proline symporter [Amino acid transport and metabolism / General function prediction only]; Region: PutP; COG0591
889738000547	Na binding site [ion binding]; other site
889738000548	PAS fold; Region: PAS_7; pfam12860
889738000549	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
889738000550	putative active site [active]
889738000551	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
889738000552	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
889738000553	dimer interface [polypeptide binding]; other site
889738000554	phosphorylation site [posttranslational modification]
889738000555	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
889738000556	ATP binding site [chemical binding]; other site
889738000557	Mg2+ binding site [ion binding]; other site
889738000558	G-X-G motif; other site
889738000559	Response regulator receiver domain; Region: Response_reg; pfam00072
889738000560	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
889738000561	active site
889738000562	phosphorylation site [posttranslational modification]
889738000563	intermolecular recognition site; other site
889738000564	dimerization interface [polypeptide binding]; other site
889738000565	Protein of unknown function, DUF485; Region: DUF485; pfam04341
889738000566	Predicted symporter [General function prediction only]; Region: DhlC; COG4147
889738000567	Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480
889738000568	Na binding site [ion binding]; other site
889738000569	BCCT family transporter; Region: BCCT; pfam02028
889738000570	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
889738000571	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
889738000572	metal binding site [ion binding]; metal-binding site
889738000573	active site
889738000574	I-site; other site
889738000575	AAA domain; Region: AAA_14; pfam13173
889738000576	excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349
889738000577	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
889738000578	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
889738000579	ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271
889738000580	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
889738000581	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
889738000582	2-enoyl thioester reductase (ETR) like proteins, child 2; Region: ETR_like_2; cd08292
889738000583	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
889738000584	putative NAD(P) binding site [chemical binding]; other site
889738000585	putative dimer interface [polypeptide binding]; other site
889738000586	Protein of unknown function (DUF1304); Region: DUF1304; pfam06993
889738000587	GlpM protein; Region: GlpM; pfam06942
889738000588	Putative transcription activator [Transcription]; Region: TenA; COG0819
889738000589	hypothetical protein; Provisional; Region: PRK14013
889738000590	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
889738000591	Major Facilitator Superfamily; Region: MFS_1; pfam07690
889738000592	putative substrate translocation pore; other site
889738000593	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
889738000594	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
889738000595	dimer interface [polypeptide binding]; other site
889738000596	ssDNA binding site [nucleotide binding]; other site
889738000597	tetramer (dimer of dimers) interface [polypeptide binding]; other site
889738000598	Branched-chain amino acid transport protein (AzlD); Region: AzlD; pfam05437
889738000599	AzlC protein; Region: AzlC; cl00570
889738000600	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
889738000601	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
889738000602	non-specific DNA binding site [nucleotide binding]; other site
889738000603	salt bridge; other site
889738000604	sequence-specific DNA binding site [nucleotide binding]; other site
889738000605	Cupin domain; Region: Cupin_2; pfam07883
889738000606	gamma-aminobutyrate permease; Region: GABAperm; TIGR01773
889738000607	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
889738000608	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
889738000609	DNA-binding site [nucleotide binding]; DNA binding site
889738000610	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
889738000611	pyridoxal 5'-phosphate binding site [chemical binding]; other site
889738000612	homodimer interface [polypeptide binding]; other site
889738000613	catalytic residue [active]
889738000614	4-aminobutyrate aminotransferase; Provisional; Region: PRK06777
889738000615	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
889738000616	inhibitor-cofactor binding pocket; inhibition site
889738000617	pyridoxal 5'-phosphate binding site [chemical binding]; other site
889738000618	catalytic residue [active]
889738000619	succinic semialdehyde dehydrogenase; Region: PLN02278
889738000620	Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103
889738000621	tetramerization interface [polypeptide binding]; other site
889738000622	NAD(P) binding site [chemical binding]; other site
889738000623	catalytic residues [active]
889738000624	LysR family transcriptional regulator; Provisional; Region: PRK14997
889738000625	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
889738000626	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
889738000627	dimerization interface [polypeptide binding]; other site
889738000628	Isochorismatase family; Region: Isochorismatase; pfam00857
889738000629	YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012
889738000630	catalytic triad [active]
889738000631	dimer interface [polypeptide binding]; other site
889738000632	conserved cis-peptide bond; other site
889738000633	Pirin-related protein [General function prediction only]; Region: COG1741
889738000634	Pirin; Region: Pirin; pfam02678
889738000635	Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726
889738000636	Predicted NAD/FAD-binding protein [General function prediction only]; Region: COG2907
889738000637	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
889738000638	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
889738000639	S-adenosylmethionine binding site [chemical binding]; other site
889738000640	Uncharacterized conserved protein [Function unknown]; Region: COG3791
889738000641	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
889738000642	Major Facilitator Superfamily; Region: MFS_1; pfam07690
889738000643	putative substrate translocation pore; other site
889738000644	Major Facilitator Superfamily; Region: MFS_1; pfam07690
889738000645	DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906
889738000646	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
889738000647	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
889738000648	dimerization interface [polypeptide binding]; other site
889738000649	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
889738000650	EamA-like transporter family; Region: EamA; pfam00892
889738000651	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
889738000652	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
889738000653	active site
889738000654	catalytic tetrad [active]
889738000655	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
889738000656	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
889738000657	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
889738000658	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
889738000659	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
889738000660	Sel1-like repeats; Region: SEL1; smart00671
889738000661	Sel1 repeat; Region: Sel1; cl02723
889738000662	Predicted transcriptional regulators [Transcription]; Region: COG1733
889738000663	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
889738000664	Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525
889738000665	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
889738000666	DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases.  They exists as monomers and homodimers; Region: NUC; cd00091
889738000667	DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892
889738000668	active site
889738000669	substrate binding site [chemical binding]; other site
889738000670	Mg2+ binding site [ion binding]; other site
889738000671	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
889738000672	Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333
889738000673	amphipathic channel; other site
889738000674	Asn-Pro-Ala signature motifs; other site
889738000675	Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625
889738000676	Helix-turn-helix domain; Region: HTH_18; pfam12833
889738000677	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
889738000678	The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731
889738000679	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
889738000680	substrate binding site [chemical binding]; other site
889738000681	glutamase interaction surface [polypeptide binding]; other site
889738000682	Homoserine Kinase, type II. Homoserine kinase is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and...; Region: HomoserineK_II; cd05153
889738000683	Phosphotransferase enzyme family; Region: APH; pfam01636
889738000684	putative active site [active]
889738000685	putative substrate binding site [chemical binding]; other site
889738000686	ATP binding site [chemical binding]; other site
889738000687	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
889738000688	DNA-binding site [nucleotide binding]; DNA binding site
889738000689	RNA-binding motif; other site
889738000690	Protein of unknown function (DUF1294); Region: DUF1294; pfam06961
889738000691	Predicted membrane protein [Function unknown]; Region: COG3671
889738000692	Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329
889738000693	EamA-like transporter family; Region: EamA; pfam00892
889738000694	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
889738000695	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
889738000696	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
889738000697	non-specific DNA binding site [nucleotide binding]; other site
889738000698	salt bridge; other site
889738000699	sequence-specific DNA binding site [nucleotide binding]; other site
889738000700	HisA.  Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732
889738000701	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
889738000702	catalytic residues [active]
889738000703	DEDDy 3'-5' exonuclease domain of WRN and similar proteins; Region: WRN_exo; cd06141
889738000704	catalytic site [active]
889738000705	putative active site [active]
889738000706	putative substrate binding site [chemical binding]; other site
889738000707	Protein of unknown function (DUF805); Region: DUF805; pfam05656
889738000708	imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141
889738000709	Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748
889738000710	putative active site [active]
889738000711	oxyanion strand; other site
889738000712	catalytic triad [active]
889738000713	Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914
889738000714	putative active site pocket [active]
889738000715	4-fold oligomerization interface [polypeptide binding]; other site
889738000716	metal binding residues [ion binding]; metal-binding site
889738000717	3-fold/trimer interface [polypeptide binding]; other site
889738000718	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
889738000719	Coenzyme A binding pocket [chemical binding]; other site
889738000720	putative acetyltransferase; Provisional; Region: PRK03624
889738000721	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
889738000722	Coenzyme A binding pocket [chemical binding]; other site
889738000723	Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550
889738000724	succinate CoA transferase; Region: YgfH_subfam; TIGR03458
889738000725	Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336
889738000726	osmolarity sensor protein; Provisional; Region: envZ; PRK09467
889738000727	HAMP domain; Region: HAMP; pfam00672
889738000728	dimerization interface [polypeptide binding]; other site
889738000729	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
889738000730	dimer interface [polypeptide binding]; other site
889738000731	phosphorylation site [posttranslational modification]
889738000732	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
889738000733	ATP binding site [chemical binding]; other site
889738000734	Mg2+ binding site [ion binding]; other site
889738000735	G-X-G motif; other site
889738000736	osmolarity response regulator; Provisional; Region: ompR; PRK09468
889738000737	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
889738000738	active site
889738000739	phosphorylation site [posttranslational modification]
889738000740	intermolecular recognition site; other site
889738000741	dimerization interface [polypeptide binding]; other site
889738000742	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
889738000743	DNA binding site [nucleotide binding]
889738000744	Transcriptional accessory protein [Transcription]; Region: Tex; COG2183
889738000745	Tex-like protein N-terminal domain; Region: Tex_N; pfam09371
889738000746	Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732
889738000747	S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685
889738000748	RNA binding site [nucleotide binding]; other site
889738000749	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
889738000750	Sulfate transporter family; Region: Sulfate_transp; pfam00916
889738000751	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378
889738000752	active site clefts [active]
889738000753	zinc binding site [ion binding]; other site
889738000754	dimer interface [polypeptide binding]; other site
889738000755	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
889738000756	classical (c) SDRs; Region: SDR_c; cd05233
889738000757	NAD(P) binding site [chemical binding]; other site
889738000758	active site
889738000759	O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK06084
889738000760	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
889738000761	homodimer interface [polypeptide binding]; other site
889738000762	substrate-cofactor binding pocket; other site
889738000763	pyridoxal 5'-phosphate binding site [chemical binding]; other site
889738000764	catalytic residue [active]
889738000765	putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819
889738000766	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
889738000767	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
889738000768	ABC transporter; Region: ABC_tran_2; pfam12848
889738000769	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
889738000770	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
889738000771	Sel1-like repeats; Region: SEL1; smart00671
889738000772	hypothetical protein; Provisional; Region: PRK10215
889738000773	Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020
889738000774	Outer membrane efflux protein; Region: OEP; pfam02321
889738000775	Outer membrane efflux protein; Region: OEP; pfam02321
889738000776	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
889738000777	Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999
889738000778	HlyD family secretion protein; Region: HlyD_3; pfam13437
889738000779	heavy metal efflux pump, CzcA family; Region: 2A0601; TIGR00914
889738000780	Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230
889738000781	S-methylmethionine transporter; Provisional; Region: PRK11387
889738000782	glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
889738000783	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
889738000784	active site
889738000785	HIGH motif; other site
889738000786	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
889738000787	active site
889738000788	KMSKS motif; other site
889738000789	ABC-type sulfate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: Sbp; COG1613
889738000790	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
889738000791	16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050
889738000792	MraW methylase family; Region: Methyltransf_5; cl17771
889738000793	Cell division protein FtsL; Region: FtsL; pfam04999
889738000794	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
889738000795	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
889738000796	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
889738000797	UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139
889738000798	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
889738000799	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
889738000800	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
889738000801	UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Region: murF; TIGR01143
889738000802	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
889738000803	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
889738000804	phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108
889738000805	Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852
889738000806	Mg++ binding site [ion binding]; other site
889738000807	putative catalytic motif [active]
889738000808	putative substrate binding site [chemical binding]; other site
889738000809	23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088
889738000810	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
889738000811	S-adenosylmethionine binding site [chemical binding]; other site
889738000812	Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane]; Region: MrcA; COG5009
889738000813	Transglycosylase; Region: Transgly; pfam00912
889738000814	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
889738000815	Competence protein A; Region: Competence_A; pfam11104
889738000816	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
889738000817	Tfp pilus assembly protein PilN [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilN; COG3166
889738000818	Fimbrial assembly protein (PilN); Region: PilN; pfam05137
889738000819	Pilus assembly protein, PilO; Region: PilO; pfam04350
889738000820	Tfp pilus assembly protein PilP [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilP; COG3168
889738000821	Pilus assembly protein, PilP; Region: PilP; pfam04351
889738000822	AMIN domain; Region: AMIN; pfam11741
889738000823	type IV pilus secretin (or competence protein) PilQ; Region: IV_pilus_PilQ; TIGR02515
889738000824	Secretin and TonB N terminus short domain; Region: STN; smart00965
889738000825	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
889738000826	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
889738000827	shikimate kinase; Reviewed; Region: aroK; PRK00131
889738000828	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
889738000829	ADP binding site [chemical binding]; other site
889738000830	magnesium binding site [ion binding]; other site
889738000831	putative shikimate binding site; other site
889738000832	Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195
889738000833	active site
889738000834	dimer interface [polypeptide binding]; other site
889738000835	metal binding site [ion binding]; metal-binding site
889738000836	glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750
889738000837	Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713
889738000838	active site
889738000839	dimer interface [polypeptide binding]; other site
889738000840	Glutamate synthase central domain; Region: Glu_syn_central; pfam04898
889738000841	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
889738000842	active site
889738000843	FMN binding site [chemical binding]; other site
889738000844	substrate binding site [chemical binding]; other site
889738000845	3Fe-4S cluster binding site [ion binding]; other site
889738000846	gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982
889738000847	domain interface; other site
889738000848	glutamate synthase small subunit family protein, proteobacterial; Region: gltD_gamma_fam; TIGR01318
889738000849	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
889738000850	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
889738000851	Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687
889738000852	Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118
889738000853	LemA family; Region: LemA; pfam04011
889738000854	Repair protein; Region: Repair_PSII; pfam04536
889738000855	Repair protein; Region: Repair_PSII; pfam04536
889738000856	Tfp pilus assembly protein, major pilin PilA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilA; COG4969
889738000857	Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544
889738000858	Pilin (bacterial filament); Region: Pilin; pfam00114
889738000859	O-antigen ligase like membrane protein; Region: O-antigen_lig; pfam13425
889738000860	Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307
889738000861	O-Antigen ligase; Region: Wzy_C; pfam04932
889738000862	Domain of unknown function (DUF3366); Region: DUF3366; pfam11846
889738000863	Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193
889738000864	Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907
889738000865	heme binding site [chemical binding]; other site
889738000866	ferroxidase pore; other site
889738000867	ferroxidase diiron center [ion binding]; other site
889738000868	Bacterioferritin-associated ferredoxin [Inorganic ion transport and metabolism]; Region: Bfd; COG2906
889738000869	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
889738000870	homotrimer interaction site [polypeptide binding]; other site
889738000871	putative active site [active]
889738000872	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
889738000873	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
889738000874	Zn2+ binding site [ion binding]; other site
889738000875	Mg2+ binding site [ion binding]; other site
889738000876	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
889738000877	synthetase active site [active]
889738000878	NTP binding site [chemical binding]; other site
889738000879	metal binding site [ion binding]; metal-binding site
889738000880	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
889738000881	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
889738000882	ACT domain; Region: ACT_4; pfam13291
889738000883	DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392
889738000884	Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194
889738000885	Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071
889738000886	catalytic site [active]
889738000887	G-X2-G-X-G-K; other site
889738000888	4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045
889738000889	4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761
889738000890	Tfp pilus assembly protein FimT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimT; COG4970
889738000891	type IV pilus modification protein PilV; Region: type_IV_pilV; TIGR02523
889738000892	von Willebrand factor type A domain; Region: VWA_2; pfam13519
889738000893	Neisseria PilC beta-propeller domain; Region: Neisseria_PilC; pfam05567
889738000894	Tfp pilus assembly protein PilE [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilE; COG4968
889738000895	Tfp pilus assembly protein PilE [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilE; COG4968
889738000896	30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040
889738000897	16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122
889738000898	RimM N-terminal domain; Region: RimM; pfam01782
889738000899	PRC-barrel domain; Region: PRC; pfam05239
889738000900	tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026
889738000901	50S ribosomal protein L19; Provisional; Region: rplS; PRK05338
889738000902	Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075
889738000903	Putative serine esterase (DUF676); Region: DUF676; pfam05057
889738000904	lipase chaperone; Provisional; Region: PRK01294
889738000905	Proteobacterial lipase chaperone protein; Region: Lipase_chap; pfam03280
889738000906	tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05033
889738000907	Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573
889738000908	RNA binding site [nucleotide binding]; other site
889738000909	active site
889738000910	Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157
889738000911	hypothetical protein; Provisional; Region: PRK10621
889738000912	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
889738000913	Hemerythrin-like domain; Region: Hr-like; cd12108
889738000914	Threonine/homoserine efflux transporter [Amino acid transport and metabolism]; Region: rhtA; COG5006
889738000915	threonine and homoserine efflux system; Provisional; Region: PRK10532
889738000916	EamA-like transporter family; Region: EamA; pfam00892
889738000917	D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790
889738000918	Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_3; cd12176
889738000919	ligand binding site [chemical binding]; other site
889738000920	NAD binding site [chemical binding]; other site
889738000921	tetramer interface [polypeptide binding]; other site
889738000922	catalytic site [active]
889738000923	C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901
889738000924	L-serine binding site [chemical binding]; other site
889738000925	ACT domain interface; other site
889738000926	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
889738000927	FAD binding domain; Region: FAD_binding_4; pfam01565
889738000928	Uncharacterized conserved protein [Function unknown]; Region: COG1359
889738000929	Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249
889738000930	multidrug efflux system translocase MdfA; Provisional; Region: PRK15402
889738000931	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
889738000932	putative substrate translocation pore; other site
889738000933	FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805
889738000934	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
889738000935	Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032
889738000936	Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305
889738000937	E-class dimer interface [polypeptide binding]; other site
889738000938	P-class dimer interface [polypeptide binding]; other site
889738000939	active site
889738000940	Cu2+ binding site [ion binding]; other site
889738000941	Zn2+ binding site [ion binding]; other site
889738000942	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
889738000943	Domain of unknown function DUF20; Region: UPF0118; pfam01594
889738000944	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
889738000945	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
889738000946	Magnesium ion binding site [ion binding]; other site
889738000947	Endonuclease related to archaeal Holliday junction resolvase; Region: Endonuc_Holl; cl01958
889738000948	Methyltransferase domain; Region: Methyltransf_23; pfam13489
889738000949	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
889738000950	S-adenosylmethionine binding site [chemical binding]; other site
889738000951	S-methylmethionine transporter; Provisional; Region: PRK11387
889738000952	Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334
889738000953	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
889738000954	NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076
889738000955	NAD(P) binding site [chemical binding]; other site
889738000956	bifunctional succinylornithine transaminase/acetylornithine transaminase; Provisional; Region: PRK12381
889738000957	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
889738000958	inhibitor-cofactor binding pocket; inhibition site
889738000959	pyridoxal 5'-phosphate binding site [chemical binding]; other site
889738000960	catalytic residue [active]
889738000961	Arginine/ornithine N-succinyltransferase beta subunit [Amino acid transport and metabolism]; Region: AstA; COG3138
889738000962	Arginine N-succinyltransferase beta subunit; Region: AstA; cl11440
889738000963	succinylglutamic semialdehyde dehydrogenase; Reviewed; Region: astD; PRK09457
889738000964	N-succinylglutamate 5-semialdehyde dehydrogenase, AstD-like; Region: ALDH_SGSD_AstD; cd07095
889738000965	NAD(P) binding site [chemical binding]; other site
889738000966	catalytic residues [active]
889738000967	succinylarginine dihydrolase; Provisional; Region: PRK13281
889738000968	Peptidase M14 Succinylglutamate desuccinylase (ASTE) subfamily; Region: M14_ASTE; cd03855
889738000969	Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952
889738000970	putative active site [active]
889738000971	Zn binding site [ion binding]; other site
889738000972	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459
889738000973	active site
889738000974	catalytic residues [active]
889738000975	Transcriptional regulator [Transcription]; Region: LysR; COG0583
889738000976	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
889738000977	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
889738000978	dimerization interface [polypeptide binding]; other site
889738000979	EamA-like transporter family; Region: EamA; pfam00892
889738000980	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
889738000981	EamA-like transporter family; Region: EamA; pfam00892
889738000982	YCII-related domain; Region: YCII; cl00999
889738000983	glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233
889738000984	Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733
889738000985	dimer interface [polypeptide binding]; other site
889738000986	motif 1; other site
889738000987	active site
889738000988	motif 2; other site
889738000989	motif 3; other site
889738000990	Protein of unknown function (DUF1311); Region: DUF1311; pfam07007
889738000991	putative DNA modification/repair radical SAM protein; Region: rSAM_link_UDG; TIGR03916
889738000992	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
889738000993	FeS/SAM binding site; other site
889738000994	probable DNA metabolism protein; Region: SAM_7_link_chp; TIGR03915
889738000995	CBS-domain-containing membrane protein [Signal transduction mechanisms]; Region: COG3448
889738000996	HPP family; Region: HPP; pfam04982
889738000997	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
889738000998	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the HPP motif domain. These proteins are integral membrane proteins with four transmembrane spanning helices. The function of these proteins is...; Region: CBS_pair_HPP_assoc; cd04600
889738000999	PspC domain; Region: PspC; pfam04024
889738001000	hypothetical protein; Provisional; Region: PRK11615
889738001001	Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418
889738001002	acyl-CoA dehydrogenase; Provisional; Region: PTZ00456
889738001003	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
889738001004	active site
889738001005	Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806
889738001006	shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258
889738001007	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
889738001008	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
889738001009	shikimate binding site; other site
889738001010	NAD(P) binding site [chemical binding]; other site
889738001011	coproporphyrinogen III oxidase; Provisional; Region: PRK05330
889738001012	Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; pfam01218
889738001013	GTP cyclohydrolase II (RibA).  GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641
889738001014	dimerization interface [polypeptide binding]; other site
889738001015	active site
889738001016	1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444
889738001017	Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007
889738001018	TPP-binding site; other site
889738001019	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
889738001020	PYR/PP interface [polypeptide binding]; other site
889738001021	dimer interface [polypeptide binding]; other site
889738001022	TPP binding site [chemical binding]; other site
889738001023	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
889738001024	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
889738001025	IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639
889738001026	active site
889738001027	dimerization interface [polypeptide binding]; other site
889738001028	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
889738001029	DEAD-like helicases superfamily; Region: DEXDc; smart00487
889738001030	ATP binding site [chemical binding]; other site
889738001031	Mg++ binding site [ion binding]; other site
889738001032	motif III; other site
889738001033	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
889738001034	nucleotide binding region [chemical binding]; other site
889738001035	ATP-binding site [chemical binding]; other site
889738001036	ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127
889738001037	ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261
889738001038	Walker A/P-loop; other site
889738001039	ATP binding site [chemical binding]; other site
889738001040	Q-loop/lid; other site
889738001041	ABC transporter signature motif; other site
889738001042	Walker B; other site
889738001043	D-loop; other site
889738001044	H-loop/switch region; other site
889738001045	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
889738001046	Permease; Region: Permease; cl00510
889738001047	ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463
889738001048	mce related protein; Region: MCE; pfam02470
889738001049	Toluene tolerance, Ttg2; Region: Tol_Tol_Ttg2; pfam05494
889738001050	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
889738001051	anti sigma factor interaction site; other site
889738001052	regulatory phosphorylation site [posttranslational modification]; other site
889738001053	Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598
889738001054	Escherichia coli Mg2+ transporter CorA_like subgroup; Region: EcCorA-like_1; cd12835
889738001055	Cl binding site [ion binding]; other site
889738001056	oligomer interface [polypeptide binding]; other site
889738001057	Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695
889738001058	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_31; cd04690
889738001059	nudix motif; other site
889738001060	comF family protein; Region: comF; TIGR00201
889738001061	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
889738001062	active site
889738001063	ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917
889738001064	RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488
889738001065	ssDNA binding site; other site
889738001066	generic binding surface II; other site
889738001067	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
889738001068	ATP binding site [chemical binding]; other site
889738001069	putative Mg++ binding site [ion binding]; other site
889738001070	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
889738001071	nucleotide binding region [chemical binding]; other site
889738001072	ATP-binding site [chemical binding]; other site
889738001073	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
889738001074	NADH(P)-binding; Region: NAD_binding_10; pfam13460
889738001075	NAD(P) binding site [chemical binding]; other site
889738001076	active site
889738001077	lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096
889738001078	glycerol-3-phosphate O-acyltransferase; Region: plsB; TIGR03703
889738001079	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Region: LPLAT_DHAPAT-like; cd07993
889738001080	putative acyl-acceptor binding pocket; other site
889738001081	Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946
889738001082	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445
889738001083	active site
889738001084	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444
889738001085	catalytic triad [active]
889738001086	dimer interface [polypeptide binding]; other site
889738001087	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
889738001088	Sodium:dicarboxylate symporter family; Region: SDF; pfam00375
889738001089	Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687
889738001090	Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118
889738001091	YihA (EngB) GTPase family; Region: YihA_EngB; cd01876
889738001092	G1 box; other site
889738001093	GTP/Mg2+ binding site [chemical binding]; other site
889738001094	Switch I region; other site
889738001095	G2 box; other site
889738001096	G3 box; other site
889738001097	Switch II region; other site
889738001098	G4 box; other site
889738001099	G5 box; other site
889738001100	Transcriptional regulator; Region: Rrf2; cl17282
889738001101	Rrf2 family protein; Region: rrf2_super; TIGR00738
889738001102	Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040
889738001103	heme-binding site [chemical binding]; other site
889738001104	Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868
889738001105	FAD binding pocket [chemical binding]; other site
889738001106	conserved FAD binding motif [chemical binding]; other site
889738001107	phosphate binding motif [ion binding]; other site
889738001108	Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872
889738001109	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
889738001110	Walker A motif; other site
889738001111	ATP binding site [chemical binding]; other site
889738001112	Walker B motif; other site
889738001113	Zonular occludens toxin (Zot); Region: Zot; cl17485
889738001114	cystathionine beta-lyase; Provisional; Region: PRK07050
889738001115	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
889738001116	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
889738001117	catalytic residue [active]
889738001118	GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518
889738001119	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741
889738001120	catalytic triad [active]
889738001121	30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596
889738001122	50S ribosomal protein L3; Validated; Region: rplC; PRK00001
889738001123	50S ribosomal protein L4; Provisional; Region: rplD; PRK05319
889738001124	50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738
889738001125	50S ribosomal protein L2; Validated; Region: rplB; PRK09374
889738001126	Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181
889738001127	Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947
889738001128	30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357
889738001129	Ribosomal protein L22/L17e.  L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit.  It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336
889738001130	putative translocon binding site; other site
889738001131	protein-rRNA interface [nucleotide binding]; other site
889738001132	30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310
889738001133	K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3  is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel.  The KH...; Region: 30S_S3_KH; cd02412
889738001134	G-X-X-G motif; other site
889738001135	Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189
889738001136	Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433
889738001137	23S rRNA interface [nucleotide binding]; other site
889738001138	5S rRNA interface [nucleotide binding]; other site
889738001139	putative antibiotic binding site [chemical binding]; other site
889738001140	L25 interface [polypeptide binding]; other site
889738001141	L27 interface [polypeptide binding]; other site
889738001142	Ribosomal L29 protein/HIP.  L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals.  L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427
889738001143	23S rRNA interface [nucleotide binding]; other site
889738001144	putative translocon interaction site; other site
889738001145	signal recognition particle (SRP54) interaction site; other site
889738001146	L23 interface [polypeptide binding]; other site
889738001147	trigger factor interaction site; other site
889738001148	30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610
889738001149	50S ribosomal protein L14; Validated; Region: rplN; PRK05483
889738001150	50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004
889738001151	KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089
889738001152	RNA binding site [nucleotide binding]; other site
889738001153	50S ribosomal protein L5; Validated; Region: rplE; PRK00010
889738001154	Ribosomal protein L5; Region: Ribosomal_L5; pfam00281
889738001155	ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673
889738001156	30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881
889738001157	30S ribosomal protein S8; Validated; Region: rpsH; PRK00136
889738001158	50S ribosomal protein L6; Validated; Region: rplF; PRK05498
889738001159	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
889738001160	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
889738001161	Ribosomal L18/L5e:  L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432
889738001162	5S rRNA interface [nucleotide binding]; other site
889738001163	23S rRNA interface [nucleotide binding]; other site
889738001164	L5 interface [polypeptide binding]; other site
889738001165	30S ribosomal protein S5; Validated; Region: rpsE; PRK00550
889738001166	Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333
889738001167	Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719
889738001168	Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658
889738001169	23S rRNA binding site [nucleotide binding]; other site
889738001170	50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592
889738001171	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204
889738001172	SecY translocase; Region: SecY; pfam00344
889738001173	Ribosomal protein L36; Region: Ribosomal_L36; pfam00444
889738001174	30S ribosomal protein S13; Validated; Region: rpsM; PRK05179
889738001175	30S ribosomal protein S13; Region: bact_S13; TIGR03631
889738001176	30S ribosomal protein S11; Validated; Region: PRK05309
889738001177	30S ribosomal protein S4; Validated; Region: rpsD; PRK05327
889738001178	Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163
889738001179	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
889738001180	RNA binding surface [nucleotide binding]; other site
889738001181	DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182
889738001182	N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928
889738001183	alphaNTD homodimer interface [polypeptide binding]; other site
889738001184	alphaNTD - beta interaction site [polypeptide binding]; other site
889738001185	alphaNTD - beta' interaction site [polypeptide binding]; other site
889738001186	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118
889738001187	50S ribosomal protein L17; Validated; Region: rplQ; PRK05591
889738001188	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
889738001189	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
889738001190	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
889738001191	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
889738001192	active site
889738001193	Flavinator of succinate dehydrogenase; Region: Sdh5; pfam03937
889738001194	rhomboid family GlyGly-CTERM serine protease; Region: rhom_GG_sort; TIGR03902
889738001195	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274
889738001196	Probable metal-binding protein (DUF2387); Region: DUF2387; pfam09526
889738001197	Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339
889738001198	Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456
889738001199	active site
889738001200	Zn binding site [ion binding]; other site
889738001201	ribonuclease R; Region: RNase_R; TIGR02063
889738001202	RNB domain; Region: RNB; pfam00773
889738001203	S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471
889738001204	RNA binding site [nucleotide binding]; other site
889738001205	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
889738001206	Nitroreductase-like family 4.  A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_4; cd02140
889738001207	dimer interface [polypeptide binding]; other site
889738001208	FMN binding site [chemical binding]; other site
889738001209	YcxB-like protein; Region: YcxB; pfam14317
889738001210	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
889738001211	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421
889738001212	Helix-turn-helix domain; Region: HTH_18; pfam12833
889738001213	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
889738001214	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
889738001215	EamA-like transporter family; Region: EamA; pfam00892
889738001216	Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918
889738001217	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
889738001218	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
889738001219	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
889738001220	active site
889738001221	Protein of unknown function (DUF3108); Region: DUF3108; pfam11306
889738001222	Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810
889738001223	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
889738001224	metal-binding heat shock protein; Provisional; Region: PRK00016
889738001225	Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702
889738001226	PhoH-like protein; Region: PhoH; pfam02562
889738001227	(dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325
889738001228	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
889738001229	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
889738001230	FeS/SAM binding site; other site
889738001231	TRAM domain; Region: TRAM; cl01282
889738001232	lytic murein transglycosylase; Provisional; Region: PRK11619
889738001233	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
889738001234	N-acetyl-D-glucosamine binding site [chemical binding]; other site
889738001235	catalytic residue [active]
889738001236	Ribonuclease T2 (RNase T2) is a widespread family of secreted RNases found in every organism examined thus far.  This family includes RNase Rh, RNase MC1, RNase LE, and self-incompatibility RNases (S-RNases).  Plant T2 RNases are expressed during leaf...; Region: RNase_T2_prok; cd01062
889738001237	B1 nucleotide binding pocket [chemical binding]; other site
889738001238	B2 nucleotide binding pocket [chemical binding]; other site
889738001239	CAS motifs; other site
889738001240	active site
889738001241	malate dehydrogenase; Provisional; Region: PRK05442
889738001242	Chloroplast-like malate dehydrogenases; Region: MDH_choloroplast_like; cd01338
889738001243	NAD(P) binding site [chemical binding]; other site
889738001244	dimer interface [polypeptide binding]; other site
889738001245	malate binding site [chemical binding]; other site
889738001246	Protein of unknown function (DUF2789); Region: DUF2789; pfam10982
889738001247	Predicted proline hydroxylase [Posttranslational modification, protein turnover, chaperones]; Region: EGL-9; COG3751
889738001248	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; pfam13640
889738001249	Protein involved in catabolism of external DNA [General function prediction only]; Region: ComJ; COG2961
889738001250	Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183
889738001251	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066
889738001252	Domain of unknown function (DUF2007); Region: DUF2007; pfam09413
889738001253	Protein of unknown function (DUF4256); Region: DUF4256; pfam14066
889738001254	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
889738001255	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
889738001256	active site
889738001257	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
889738001258	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
889738001259	Protein of unknown function (DUF1446); Region: DUF1446; pfam07287
889738001260	RUN domain; Region: RUN; cl02689
889738001261	Trans-2-enoyl-CoA reductase (TER) and 2,4-dienoyl-CoA reductase (DECR), atypical (a) SDR; Region: TER_DECR_SDR_a; cd05369
889738001262	NAD(P) binding site [chemical binding]; other site
889738001263	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
889738001264	substrate binding site [chemical binding]; other site
889738001265	homotetramer interface [polypeptide binding]; other site
889738001266	active site
889738001267	homodimer interface [polypeptide binding]; other site
889738001268	Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799
889738001269	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
889738001270	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
889738001271	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
889738001272	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
889738001273	active site
889738001274	enoyl-CoA hydratase; Provisional; Region: PRK05995
889738001275	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
889738001276	substrate binding site [chemical binding]; other site
889738001277	oxyanion hole (OAH) forming residues; other site
889738001278	trimer interface [polypeptide binding]; other site
889738001279	Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770
889738001280	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
889738001281	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
889738001282	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785
889738001283	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
889738001284	carboxyltransferase (CT) interaction site; other site
889738001285	biotinylation site [posttranslational modification]; other site
889738001286	ClpXP protease specificity-enhancing factor; Provisional; Region: PRK11798
889738001287	stringent starvation protein A; Provisional; Region: sspA; PRK09481
889738001288	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
889738001289	C-terminal, alpha helical domain of Stringent starvation protein A; Region: GST_C_SspA; cd03186
889738001290	dimer interface [polypeptide binding]; other site
889738001291	N-terminal domain interface [polypeptide binding]; other site
889738001292	30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132
889738001293	Ribosomal protein L13.  Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392
889738001294	23S rRNA interface [nucleotide binding]; other site
889738001295	L3 interface [polypeptide binding]; other site
889738001296	4-hydroxythreonine-4-phosphate dehydrogenase; Region: pdxA; TIGR00557
889738001297	4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743
889738001298	16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274
889738001299	Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030
889738001300	diadenosine tetraphosphatase; Reviewed; Region: apaH; PRK00166
889738001301	Escherichia coli ApaH and related proteins, metallophosphatase domain; Region: MPP_ApaH; cd07422
889738001302	active site
889738001303	metal binding site [ion binding]; metal-binding site
889738001304	Uncharacterized protein conserved in bacteria (DUF2147); Region: DUF2147; pfam09917
889738001305	LrgB-like family; Region: LrgB; cl00596
889738001306	GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167
889738001307	GTP-binding protein HflX; Region: GTP_HflX; TIGR03156
889738001308	HflX GTPase family; Region: HflX; cd01878
889738001309	G1 box; other site
889738001310	GTP/Mg2+ binding site [chemical binding]; other site
889738001311	Switch I region; other site
889738001312	G2 box; other site
889738001313	G3 box; other site
889738001314	Switch II region; other site
889738001315	G4 box; other site
889738001316	G5 box; other site
889738001317	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
889738001318	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
889738001319	putative acyl-acceptor binding pocket; other site
889738001320	Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502
889738001321	Putative catalytic domain, repeat 1, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_1; cd09111
889738001322	putative active site [active]
889738001323	catalytic site [active]
889738001324	Putative catalytic domain, repeat 2, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_2; cd09113
889738001325	putative active site [active]
889738001326	catalytic site [active]
889738001327	phosphodiesterase YaeI; Provisional; Region: PRK11340
889738001328	Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385
889738001329	putative active site [active]
889738001330	putative metal binding site [ion binding]; other site
889738001331	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
889738001332	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
889738001333	ligand binding site [chemical binding]; other site
889738001334	putative inner membrane diguanylate cyclase; Provisional; Region: PRK09966
889738001335	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
889738001336	metal binding site [ion binding]; metal-binding site
889738001337	active site
889738001338	I-site; other site
889738001339	Domain of unknown function (DUF4154); Region: DUF4154; pfam13689
889738001340	dihydrolipoamide dehydrogenase; Validated; Region: PRK06292
889738001341	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
889738001342	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
889738001343	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
889738001344	Putative phosphatase (DUF442); Region: DUF442; cl17385
889738001345	Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073
889738001346	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
889738001347	thioredoxin 2; Provisional; Region: PRK10996
889738001348	zinc-ribbon domain; Region: zinc_ribbon_5; cl11777
889738001349	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
889738001350	catalytic residues [active]
889738001351	Brown fat-inducible thioesterase (BFIT).  Brain acyl-CoA hydrolase (BACH).  These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442
889738001352	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
889738001353	CoenzymeA binding site [chemical binding]; other site
889738001354	subunit interaction site [polypeptide binding]; other site
889738001355	PHB binding site; other site
889738001356	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666
889738001357	Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740
889738001358	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
889738001359	active site residue [active]
889738001360	bifunctional tRNA (mnm(5)s(2)U34)-methyltransferase/FAD-dependent cmnm(5)s(2)U34 oxidoreductase; Reviewed; Region: mnmC; PRK01747
889738001361	Uncharacterized conserved protein [Function unknown]; Region: COG4121
889738001362	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
889738001363	YciI-like protein; Reviewed; Region: PRK11370
889738001364	Intracellular septation protein A; Region: IspA; pfam04279
889738001365	Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613
889738001366	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438
889738001367	active site
889738001368	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438
889738001369	Bestrophin, RFP-TM, chloride channel; Region: Bestrophin; pfam01062
889738001370	hypothetical protein; Reviewed; Region: PRK00024
889738001371	Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
889738001372	MPN+ (JAMM) motif; other site
889738001373	Zinc-binding site [ion binding]; other site
889738001374	bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579
889738001375	Flavoprotein; Region: Flavoprotein; pfam02441
889738001376	DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127
889738001377	preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022
889738001378	SecD/SecF GG Motif; Region: Sec_GG; pfam07549
889738001379	Protein export membrane protein; Region: SecD_SecF; pfam02355
889738001380	SecD export protein N-terminal TM region; Region: SecD-TM1; pfam13721
889738001381	preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812
889738001382	SecD/SecF GG Motif; Region: Sec_GG; pfam07549
889738001383	protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916
889738001384	preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585
889738001385	queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112
889738001386	Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343
889738001387	LemA family; Region: LemA; cl00742
889738001388	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147
889738001389	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113
889738001390	KAP family P-loop domain; Region: KAP_NTPase; pfam07693
889738001391	Predicted P-loop ATPase [General function prediction only]; Region: COG4928
889738001392	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
889738001393	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
889738001394	dimer interface [polypeptide binding]; other site
889738001395	phosphorylation site [posttranslational modification]
889738001396	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
889738001397	ATP binding site [chemical binding]; other site
889738001398	Mg2+ binding site [ion binding]; other site
889738001399	G-X-G motif; other site
889738001400	bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Reviewed; Region: PRK11072
889738001401	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
889738001402	metal binding triad; other site
889738001403	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
889738001404	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
889738001405	metal binding triad; other site
889738001406	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
889738001407	BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids  leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557
889738001408	homodimer interface [polypeptide binding]; other site
889738001409	substrate-cofactor binding pocket; other site
889738001410	catalytic residue [active]
889738001411	Predicted nucleoside-diphosphate-sugar epimerase [Cell envelope biogenesis, outer membrane]; Region: COG3660
889738001412	Mitochondrial fission ELM1; Region: Mito_fiss_Elm1; pfam06258
889738001413	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736
889738001414	phosphorylation site [posttranslational modification]
889738001415	Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524
889738001416	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
889738001417	Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918
889738001418	putative active site [active]
889738001419	putative metal binding site [ion binding]; other site
889738001420	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
889738001421	UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511
889738001422	putative metal binding site; other site
889738001423	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
889738001424	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
889738001425	Glycosyltransferase family 25 [lipooligosaccharide (LOS) biosynthesis protein] is a family of glycosyltransferases involved in LOS biosynthesis. The members include the beta(1,4) galactosyltransferases: Lgt2 of Moraxella catarrhalis, LgtB and LgtE of...; Region: Glyco_transf_25; cd06532
889738001426	Protein of unknown function (DUF3184); Region: DUF3184; pfam11380
889738001427	aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476
889738001428	EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317
889738001429	dimer interface [polypeptide binding]; other site
889738001430	anticodon binding site; other site
889738001431	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
889738001432	homodimer interface [polypeptide binding]; other site
889738001433	motif 1; other site
889738001434	active site
889738001435	motif 2; other site
889738001436	GAD domain; Region: GAD; pfam02938
889738001437	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
889738001438	active site
889738001439	motif 3; other site
889738001440	Domain of unknown function (DUF4184); Region: DUF4184; pfam13803
889738001441	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
889738001442	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
889738001443	N-terminal plug; other site
889738001444	ligand-binding site [chemical binding]; other site
889738001445	Putative catalytic domain, repeat 1, of uncharacterized phospholipase D-like proteins; Region: PLDc_unchar2_1; cd09129
889738001446	putative active site [active]
889738001447	putative catalytic site [active]
889738001448	Putative catalytic domain, repeat 2, of uncharacterized phospholipase D-like proteins; Region: PLDc_unchar2_2; cd09130
889738001449	PLD-like domain; Region: PLDc_2; pfam13091
889738001450	putative active site [active]
889738001451	putative catalytic site [active]
889738001452	Domain of unknown function (DUF3315); Region: DUF3315; pfam11776
889738001453	Predicted membrane protein [Function unknown]; Region: COG3223
889738001454	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
889738001455	GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057
889738001456	C-terminal domain interface [polypeptide binding]; other site
889738001457	GSH binding site (G-site) [chemical binding]; other site
889738001458	dimer interface [polypeptide binding]; other site
889738001459	C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188
889738001460	dimer interface [polypeptide binding]; other site
889738001461	substrate binding pocket (H-site) [chemical binding]; other site
889738001462	N-terminal domain interface [polypeptide binding]; other site
889738001463	LysR family transcriptional regulator; Provisional; Region: PRK14997
889738001464	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
889738001465	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
889738001466	putative effector binding pocket; other site
889738001467	dimerization interface [polypeptide binding]; other site
889738001468	acyl-CoA dehydrogenase; Provisional; Region: PTZ00456
889738001469	Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418
889738001470	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
889738001471	active site
889738001472	Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806
889738001473	Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418
889738001474	acyl-CoA dehydrogenase; Provisional; Region: PTZ00456
889738001475	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
889738001476	active site
889738001477	Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806
889738001478	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
889738001479	dimerization interface [polypeptide binding]; other site
889738001480	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
889738001481	dimer interface [polypeptide binding]; other site
889738001482	phosphorylation site [posttranslational modification]
889738001483	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
889738001484	ATP binding site [chemical binding]; other site
889738001485	Mg2+ binding site [ion binding]; other site
889738001486	G-X-G motif; other site
889738001487	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
889738001488	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
889738001489	active site
889738001490	phosphorylation site [posttranslational modification]
889738001491	intermolecular recognition site; other site
889738001492	dimerization interface [polypeptide binding]; other site
889738001493	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
889738001494	DNA binding site [nucleotide binding]
889738001495	Uncharacterized conserved protein [Function unknown]; Region: COG0397
889738001496	hypothetical protein; Validated; Region: PRK00029
889738001497	The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505
889738001498	Fatty acid desaturase; Region: FA_desaturase; pfam00487
889738001499	Di-iron ligands [ion binding]; other site
889738001500	META domain; Region: META; pfam03724
889738001501	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
889738001502	Glycerophosphodiester phosphodiesterase domain as found in prokaryota and eukaryota, and similar proteins; Region: GDPD; cd08556
889738001503	active site
889738001504	catalytic site [active]
889738001505	metal binding site [ion binding]; metal-binding site
889738001506	Cobalamin adenosyltransferase; Region: Cob_adeno_trans; pfam01923
889738001507	Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206
889738001508	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
889738001509	N-terminal plug; other site
889738001510	ligand-binding site [chemical binding]; other site
889738001511	Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405
889738001512	active site
889738001513	tryptophan synthase, beta subunit; Region: trpB; TIGR00263
889738001514	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
889738001515	pyridoxal 5'-phosphate binding site [chemical binding]; other site
889738001516	catalytic residue [active]
889738001517	Domain of Unknown Function (DUF1543); Region: DUF1543; pfam07566
889738001518	Protein of unknown function (DUF2804); Region: DUF2804; pfam10974
889738001519	Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687
889738001520	Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118
889738001521	Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625
889738001522	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
889738001523	tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200
889738001524	Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724
889738001525	substrate binding site [chemical binding]; other site
889738001526	active site
889738001527	catalytic residues [active]
889738001528	heterodimer interface [polypeptide binding]; other site
889738001529	acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654
889738001530	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
889738001531	Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285
889738001532	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
889738001533	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
889738001534	Sporulation related domain; Region: SPOR; cl10051
889738001535	Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053
889738001536	active site
889738001537	catalytic residues [active]
889738001538	Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753
889738001539	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
889738001540	Peroxiredoxin (PRX) family, 1-cys PRX subfamily; composed of PRXs containing only one conserved cysteine, which serves as the peroxidatic cysteine. They are homodimeric thiol-specific antioxidant (TSA) proteins that confer a protective role in cells by...; Region: PRX_1cys; cd03016
889738001541	dimer interface [polypeptide binding]; other site
889738001542	decamer (pentamer of dimers) interface [polypeptide binding]; other site
889738001543	catalytic triad [active]
889738001544	preprotein translocase subunit SecA; Reviewed; Region: PRK12904
889738001545	SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958
889738001546	SEC-C motif; Region: SEC-C; pfam02810
889738001547	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
889738001548	metabolite-proton symporter; Region: 2A0106; TIGR00883
889738001549	putative substrate translocation pore; other site
889738001550	Haemolysin-III related; Region: HlyIII; cl03831
889738001551	channel protein, hemolysin III family; Region: hlyIII; TIGR01065
889738001552	Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; pfam13444
889738001553	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
889738001554	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667
889738001555	Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208
889738001556	active site
889738001557	nucleophile elbow; other site
889738001558	multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154
889738001559	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
889738001560	substrate binding site [chemical binding]; other site
889738001561	oxyanion hole (OAH) forming residues; other site
889738001562	trimer interface [polypeptide binding]; other site
889738001563	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
889738001564	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
889738001565	acetyl-CoA acetyltransferase; Validated; Region: PRK08242
889738001566	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
889738001567	dimer interface [polypeptide binding]; other site
889738001568	active site
889738001569	Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625
889738001570	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
889738001571	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
889738001572	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
889738001573	CoA-transferase family III; Region: CoA_transf_3; pfam02515
889738001574	Carbohydrate-selective porin, OprB family; Region: OprB; cl17816
889738001575	membrane-bound PQQ-dependent dehydrogenase, glucose/quinate/shikimate family; Region: PQQ_membr_DH; TIGR03074
889738001576	Membrane-bound PQQ-dependent glucose dehydrogenase; Region: PQQ_mGDH; cd10280
889738001577	Trp docking motif [polypeptide binding]; other site
889738001578	putative active site [active]
889738001579	Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155
889738001580	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
889738001581	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
889738001582	Bacterial protein of unknown function (DUF934); Region: DUF934; pfam06073
889738001583	Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076
889738001584	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
889738001585	Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588
889738001586	dimer interface [polypeptide binding]; other site
889738001587	acetyl-CoA acetyltransferase; Provisional; Region: PRK06954
889738001588	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
889738001589	dimer interface [polypeptide binding]; other site
889738001590	active site
889738001591	Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830
889738001592	Type II transport protein GspH; Region: GspH; pfam12019
889738001593	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505
889738001594	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
889738001595	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
889738001596	ligand binding site [chemical binding]; other site
889738001597	Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139
889738001598	hypothetical protein; Reviewed; Region: PRK09588
889738001599	lysine transporter; Provisional; Region: PRK10836
889738001600	16S ribosomal RNA m2G1207 methyltransferase; Provisional; Region: rsmC; PRK09489
889738001601	Methyltransferase small domain N-terminal; Region: MTS_N; pfam08468
889738001602	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
889738001603	S-adenosylmethionine binding site [chemical binding]; other site
889738001604	Xanthine/uracil permeases [Nucleotide transport and metabolism]; Region: UraA; COG2233
889738001605	Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217
889738001606	Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891
889738001607	G1 box; other site
889738001608	putative GEF interaction site [polypeptide binding]; other site
889738001609	GTP/Mg2+ binding site [chemical binding]; other site
889738001610	Switch I region; other site
889738001611	G2 box; other site
889738001612	G3 box; other site
889738001613	Switch II region; other site
889738001614	G4 box; other site
889738001615	G5 box; other site
889738001616	BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu.  BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691
889738001617	BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants.  BipA is a highly...; Region: BipA_TypA_C; cd03710
889738001618	large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13952
889738001619	large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567
889738001620	GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661
889738001621	putative active site pocket [active]
889738001622	dimerization interface [polypeptide binding]; other site
889738001623	putative catalytic residue [active]
889738001624	PPIC-type PPIASE domain; Region: Rotamase_2; cl08278
889738001625	formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103
889738001626	N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966
889738001627	DNA binding site [nucleotide binding]
889738001628	catalytic residue [active]
889738001629	H2TH interface [polypeptide binding]; other site
889738001630	putative catalytic residues [active]
889738001631	turnover-facilitating residue; other site
889738001632	intercalation triad [nucleotide binding]; other site
889738001633	8OG recognition residue [nucleotide binding]; other site
889738001634	putative reading head residues; other site
889738001635	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
889738001636	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
889738001637	Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540
889738001638	active site
889738001639	DNA binding site [nucleotide binding]
889738001640	Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206
889738001641	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
889738001642	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
889738001643	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
889738001644	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
889738001645	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
889738001646	Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis.  Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932
889738001647	active site
889738001648	FMN binding site [chemical binding]; other site
889738001649	substrate binding site [chemical binding]; other site
889738001650	homotetramer interface [polypeptide binding]; other site
889738001651	catalytic residue [active]
889738001652	Predicted permeases [General function prediction only]; Region: COG0679
889738001653	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
889738001654	Sel1-like repeats; Region: SEL1; smart00671
889738001655	protein disulfide isomerase II DsbC; Provisional; Region: PRK10877
889738001656	DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020
889738001657	dimerization domain [polypeptide binding]; other site
889738001658	dimer interface [polypeptide binding]; other site
889738001659	catalytic residues [active]
889738001660	Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354
889738001661	folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317
889738001662	Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_2; cd08895
889738001663	putative hydrophobic ligand binding site [chemical binding]; other site
889738001664	Uncharacterized conserved protein [Function unknown]; Region: COG3189
889738001665	Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824
889738001666	PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274
889738001667	PhnA protein; Region: PhnA; pfam03831
889738001668	Uncharacterized conserved protein [Function unknown]; Region: COG3422
889738001669	Domain of unknown function (DUF1508); Region: DUF1508; pfam07411
889738001670	prolyl-tRNA synthetase; Provisional; Region: PRK09194
889738001671	Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779
889738001672	dimer interface [polypeptide binding]; other site
889738001673	motif 1; other site
889738001674	active site
889738001675	motif 2; other site
889738001676	INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334
889738001677	putative deacylase active site [active]
889738001678	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
889738001679	active site
889738001680	motif 3; other site
889738001681	ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861
889738001682	anticodon binding site; other site
889738001683	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
889738001684	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
889738001685	HlyD family secretion protein; Region: HlyD_3; pfam13437
889738001686	Response regulator receiver domain; Region: Response_reg; pfam00072
889738001687	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
889738001688	active site
889738001689	phosphorylation site [posttranslational modification]
889738001690	intermolecular recognition site; other site
889738001691	dimerization interface [polypeptide binding]; other site
889738001692	Response regulator receiver domain; Region: Response_reg; pfam00072
889738001693	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
889738001694	active site
889738001695	phosphorylation site [posttranslational modification]
889738001696	intermolecular recognition site; other site
889738001697	dimerization interface [polypeptide binding]; other site
889738001698	Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835
889738001699	Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675
889738001700	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
889738001701	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
889738001702	dimer interface [polypeptide binding]; other site
889738001703	putative CheW interface [polypeptide binding]; other site
889738001704	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
889738001705	putative binding surface; other site
889738001706	active site
889738001707	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
889738001708	putative binding surface; other site
889738001709	active site
889738001710	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
889738001711	putative binding surface; other site
889738001712	active site
889738001713	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
889738001714	putative binding surface; other site
889738001715	active site
889738001716	Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895
889738001717	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
889738001718	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
889738001719	ATP binding site [chemical binding]; other site
889738001720	Mg2+ binding site [ion binding]; other site
889738001721	G-X-G motif; other site
889738001722	CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731
889738001723	Response regulator receiver domain; Region: Response_reg; pfam00072
889738001724	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
889738001725	active site
889738001726	phosphorylation site [posttranslational modification]
889738001727	intermolecular recognition site; other site
889738001728	dimerization interface [polypeptide binding]; other site
889738001729	succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009
889738001730	M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891
889738001731	metal binding site [ion binding]; metal-binding site
889738001732	dimer interface [polypeptide binding]; other site
889738001733	Predicted small secreted protein [Function unknown]; Region: COG5510
889738001734	Domain of unknown function (DUF1853); Region: DUF1853; cl01545
889738001735	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2832
889738001736	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
889738001737	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
889738001738	Uncharacterized conserved protein [Function unknown]; Region: COG1434
889738001739	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
889738001740	putative active site [active]
889738001741	Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182
889738001742	PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172
889738001743	PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703
889738001744	Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; Region: CysJ; COG0369
889738001745	Flavodoxin; Region: Flavodoxin_1; pfam00258
889738001746	Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR_like1; cd06200
889738001747	FAD binding pocket [chemical binding]; other site
889738001748	FAD binding motif [chemical binding]; other site
889738001749	catalytic residues [active]
889738001750	NAD binding pocket [chemical binding]; other site
889738001751	phosphate binding motif [ion binding]; other site
889738001752	beta-alpha-beta structure motif; other site
889738001753	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
889738001754	YcxB-like protein; Region: YcxB; pfam14317
889738001755	TIGR01666 family membrane protein; Region: YCCS
889738001756	FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805
889738001757	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
889738001758	bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102
889738001759	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
889738001760	putative substrate translocation pore; other site
889738001761	Nitroreductase family. Members of this family utilize FMN as a cofactor and catalyze reduction of a variety of nitroaromatic compounds, including nitrofurans, nitrobenzens, nitrophenol, nitrobenzoate and quinones by using either NADH or NADPH as a source...; Region: Nitroreductase; cd02136
889738001762	putative FMN binding site [chemical binding]; other site
889738001763	Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115
889738001764	Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548
889738001765	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752
889738001766	Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205
889738001767	active site
889738001768	nucleophile elbow; other site
889738001769	threonine dehydratase; Provisional; Region: PRK07334
889738001770	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
889738001771	tetramer interface [polypeptide binding]; other site
889738001772	pyridoxal 5'-phosphate binding site [chemical binding]; other site
889738001773	catalytic residue [active]
889738001774	C-terminal ACT domain of biodegradative (catabolic) threonine dehydratase II (ThrD-II) and other related ACT domains; Region: ACT_ThrD-II-like; cd04886
889738001775	microcin B17 transporter; Reviewed; Region: PRK11098
889738001776	Protein of unknown function (DUF1176); Region: DUF1176; pfam06674
889738001777	intracellular protease, PfpI family; Region: PfpI; TIGR01382
889738001778	Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_1; cd03169
889738001779	conserved cys residue [active]
889738001780	aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477
889738001781	GatB/GatE catalytic domain; Region: GatB_N; pfam02934
889738001782	GatB domain; Region: GatB_Yqey; smart00845
889738001783	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
889738001784	aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012
889738001785	aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034
889738001786	rod shape-determining protein MreB; Provisional; Region: PRK13927
889738001787	MreB and similar proteins; Region: MreB_like; cd10225
889738001788	nucleotide binding site [chemical binding]; other site
889738001789	Mg binding site [ion binding]; other site
889738001790	putative protofilament interaction site [polypeptide binding]; other site
889738001791	RodZ interaction site [polypeptide binding]; other site
889738001792	rod shape-determining protein MreC; Provisional; Region: PRK13922
889738001793	rod shape-determining protein MreC; Region: MreC; pfam04085
889738001794	rod shape-determining protein MreD; Region: shape_MreD; TIGR03426
889738001795	Maf-like protein; Region: Maf; pfam02545
889738001796	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
889738001797	active site
889738001798	dimer interface [polypeptide binding]; other site
889738001799	ribonuclease G; Provisional; Region: PRK11712
889738001800	S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453
889738001801	homodimer interface [polypeptide binding]; other site
889738001802	oligonucleotide binding site [chemical binding]; other site
889738001803	acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946
889738001804	Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007
889738001805	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
889738001806	Active Sites [active]
889738001807	phosphoserine phosphatase; Provisional; Region: thrH; PRK13582
889738001808	Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560
889738001809	Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; cl17479
889738001810	Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; cl17479
889738001811	Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525
889738001812	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
889738001813	Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625
889738001814	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
889738001815	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
889738001816	This CD includes the dihydrorhizobitoxine fatty acid desaturase (RtxC) characterized in Bradyrhizobium japonicum USDA110, and other related proteins. Dihydrorhizobitoxine desaturase is reported to be involved in the final step of rhizobitoxine...; Region: Rhizobitoxine-FADS-like; cd03510
889738001817	putative di-iron ligands [ion binding]; other site
889738001818	This CD includes the dihydrorhizobitoxine fatty acid desaturase (RtxC) characterized in Bradyrhizobium japonicum USDA110, and other related proteins. Dihydrorhizobitoxine desaturase is reported to be involved in the final step of rhizobitoxine...; Region: Rhizobitoxine-FADS-like; cd03510
889738001819	Mrr N-terminal domain; Region: Mrr_N; pfam14338
889738001820	PaaX-like protein C-terminal domain; Region: PaaX_C; pfam08223
889738001821	undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281
889738001822	AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719
889738001823	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
889738001824	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
889738001825	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
889738001826	putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824
889738001827	PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276
889738001828	NAD(P) binding site [chemical binding]; other site
889738001829	chaperone protein HchA; Provisional; Region: PRK04155
889738001830	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
889738001831	conserved cys residue [active]
889738001832	Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113
889738001833	probable AcnD-accessory protein PrpF; Region: prpF; TIGR02334
889738001834	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
889738001835	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
889738001836	substrate binding pocket [chemical binding]; other site
889738001837	chain length determination region; other site
889738001838	substrate-Mg2+ binding site; other site
889738001839	catalytic residues [active]
889738001840	aspartate-rich region 1; other site
889738001841	active site lid residues [active]
889738001842	aspartate-rich region 2; other site
889738001843	Protein of unknown function (DUF419); Region: DUF419; cl15265
889738001844	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
889738001845	Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403
889738001846	Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585
889738001847	hypothetical protein; Provisional; Region: PRK10279
889738001848	Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205
889738001849	nucleophile elbow; other site
889738001850	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
889738001851	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown ABO13168; Region: LPLAT_ABO13168-like; cd07988
889738001852	putative acyl-acceptor binding pocket; other site
889738001853	muropeptide transporter; Validated; Region: ampG; cl17669
889738001854	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
889738001855	putative metal dependent hydrolase; Provisional; Region: PRK11598
889738001856	Domain of unknown function (DUF1705); Region: DUF1705; pfam08019
889738001857	Sulfatase; Region: Sulfatase; pfam00884
889738001858	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
889738001859	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
889738001860	active site
889738001861	phosphorylation site [posttranslational modification]
889738001862	intermolecular recognition site; other site
889738001863	dimerization interface [polypeptide binding]; other site
889738001864	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
889738001865	DNA binding site [nucleotide binding]
889738001866	sensor protein QseC; Provisional; Region: PRK10337
889738001867	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
889738001868	dimer interface [polypeptide binding]; other site
889738001869	phosphorylation site [posttranslational modification]
889738001870	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
889738001871	ATP binding site [chemical binding]; other site
889738001872	Mg2+ binding site [ion binding]; other site
889738001873	G-X-G motif; other site
889738001874	PAP2_like_6 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which mainly contains bacterial proteins, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_6; cd03396
889738001875	active site
889738001876	Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004
889738001877	Transcriptional regulator [Transcription]; Region: LysR; COG0583
889738001878	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
889738001879	putative DNA binding site [nucleotide binding]; other site
889738001880	putative Zn2+ binding site [ion binding]; other site
889738001881	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
889738001882	dimerization interface [polypeptide binding]; other site
889738001883	Predicted permeases [General function prediction only]; Region: COG0679
889738001884	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
889738001885	S-adenosylmethionine binding site [chemical binding]; other site
889738001886	valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729
889738001887	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
889738001888	HIGH motif; other site
889738001889	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
889738001890	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
889738001891	active site
889738001892	KMSKS motif; other site
889738001893	Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962
889738001894	tRNA binding surface [nucleotide binding]; other site
889738001895	anticodon binding site; other site
889738001896	Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458
889738001897	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
889738001898	short chain dehydrogenase; Provisional; Region: PRK06181
889738001899	NAD(P) binding site [chemical binding]; other site
889738001900	active site
889738001901	SnoaL-like domain; Region: SnoaL_4; pfam13577
889738001902	Uncharacterized conserved protein [Function unknown]; Region: COG0393
889738001903	Putative heavy-metal-binding; Region: YbjQ_1; cl00426
889738001904	Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538
889738001905	The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915
889738001906	Protein export membrane protein; Region: SecD_SecF; cl14618
889738001907	multidrug efflux system transporter AcrA; Provisional; Region: PRK15030
889738001908	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
889738001909	HlyD family secretion protein; Region: HlyD_3; pfam13437
889738001910	PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392
889738001911	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
889738001912	active site
889738001913	Site-specific recombinase; Region: SpecificRecomb; pfam10136
889738001914	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
889738001915	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
889738001916	substrate binding pocket [chemical binding]; other site
889738001917	chain length determination region; other site
889738001918	substrate-Mg2+ binding site; other site
889738001919	catalytic residues [active]
889738001920	aspartate-rich region 1; other site
889738001921	active site lid residues [active]
889738001922	aspartate-rich region 2; other site
889738001923	50S ribosomal protein L21; Validated; Region: rplU; PRK05573
889738001924	50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278
889738001925	50S ribosomal protein L27; Validated; Region: rpmA; PRK05435
889738001926	lipoprotein chaperone; Reviewed; Region: lolA; PRK00031
889738001927	Outer membrane lipoprotein carrier protein LolA; Region: LolA; pfam03548
889738001928	Protein of unknown function (DUF3298); Region: DUF3298; pfam11738
889738001929	seryl-tRNA synthetase; Provisional; Region: PRK05431
889738001930	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
889738001931	Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770
889738001932	dimer interface [polypeptide binding]; other site
889738001933	active site
889738001934	motif 1; other site
889738001935	motif 2; other site
889738001936	motif 3; other site
889738001937	siroheme synthase; Provisional; Region: cysG; PRK10637
889738001938	Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241
889738001939	Sirohaem synthase dimerisation region; Region: CysG_dimeriser; pfam10414
889738001940	Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642
889738001941	active site
889738001942	SAM binding site [chemical binding]; other site
889738001943	homodimer interface [polypeptide binding]; other site
889738001944	Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219
889738001945	Predicted transcriptional regulators [Transcription]; Region: COG1733
889738001946	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
889738001947	Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655
889738001948	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
889738001949	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
889738001950	Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454
889738001951	Iron-containing alcohol dehydrogenases-like; Region: Fe-ADH5; cd08189
889738001952	putative active site [active]
889738001953	metal binding site [ion binding]; metal-binding site
889738001954	lipoate-protein ligase B; Provisional; Region: PRK14342
889738001955	Protein of unknown function (DUF493); Region: DUF493; pfam04359
889738001956	Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979
889738001957	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
889738001958	Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546
889738001959	RNA polymerase sigma factor RpoD, C-terminal domain; Region: RpoD_Cterm; TIGR02393
889738001960	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
889738001961	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
889738001962	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
889738001963	DNA binding residues [nucleotide binding]
889738001964	Uncharacterized protein family (UPF0149); Region: UPF0149; pfam03695
889738001965	Predicted sulfurtransferase [General function prediction only]; Region: COG1054
889738001966	Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518
889738001967	active site residue [active]
889738001968	Protein of unknown function (DUF1289); Region: DUF1289; pfam06945
889738001969	Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114
889738001970	Citrate synthase [Energy production and conversion]; Region: GltA; COG0372
889738001971	dimer interface [polypeptide binding]; other site
889738001972	active site
889738001973	citrylCoA binding site [chemical binding]; other site
889738001974	NADH binding [chemical binding]; other site
889738001975	cationic pore residues; other site
889738001976	oxalacetate/citrate binding site [chemical binding]; other site
889738001977	coenzyme A binding site [chemical binding]; other site
889738001978	catalytic triad [active]
889738001979	Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499
889738001980	Iron-sulfur protein interface; other site
889738001981	proximal quinone binding site [chemical binding]; other site
889738001982	SdhD (CybS) interface [polypeptide binding]; other site
889738001983	proximal heme binding site [chemical binding]; other site
889738001984	Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. E. coli SQR, a member of this subfamily, reduces the...; Region: SQR_TypeC_SdhD; cd03494
889738001985	SdhC subunit interface [polypeptide binding]; other site
889738001986	proximal heme binding site [chemical binding]; other site
889738001987	cardiolipin binding site; other site
889738001988	Iron-sulfur protein interface; other site
889738001989	proximal quinone binding site [chemical binding]; other site
889738001990	succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07057
889738001991	L-aspartate oxidase; Provisional; Region: PRK06175
889738001992	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
889738001993	succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950
889738001994	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085
889738001995	2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404
889738001996	Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016
889738001997	TPP-binding site [chemical binding]; other site
889738001998	Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779
889738001999	dihydrolipoamide succinyltransferase; Validated; Region: PRK05704
889738002000	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
889738002001	E3 interaction surface; other site
889738002002	lipoyl attachment site [posttranslational modification]; other site
889738002003	e3 binding domain; Region: E3_binding; pfam02817
889738002004	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
889738002005	dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06467
889738002006	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
889738002007	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
889738002008	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
889738002009	succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696
889738002010	ATP-grasp domain; Region: ATP-grasp_2; pfam08442
889738002011	CoA-ligase; Region: Ligase_CoA; pfam00549
889738002012	succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678
889738002013	CoA binding domain; Region: CoA_binding; smart00881
889738002014	CoA-ligase; Region: Ligase_CoA; pfam00549
889738002015	tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282
889738002016	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
889738002017	active site
889738002018	HIGH motif; other site
889738002019	dimer interface [polypeptide binding]; other site
889738002020	KMSKS motif; other site
889738002021	Protein of unknown function (DUF808); Region: DUF808; pfam05661
889738002022	Predicted metalloprotease [General function prediction only]; Region: COG2321
889738002023	Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228
889738002024	NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025
889738002025	tail sheath protein; Provisional; Region: 18; PHA02539
889738002026	Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753
889738002027	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
889738002028	type I secretion C-terminal target domain (VC_A0849 subclass); Region: T1SS_VCA0849; TIGR03661
889738002029	type 2 lantibiotic biosynthesis protein LanM; Region: lanti_2_LanM; TIGR03897
889738002030	CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381
889738002031	putative active site [active]
889738002032	putative metal binding site [ion binding]; other site
889738002033	Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854
889738002034	Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064
889738002035	active site
889738002036	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
889738002037	DNA binding site [nucleotide binding]
889738002038	active site
889738002039	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
889738002040	Ligand Binding Site [chemical binding]; other site
889738002041	Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110
889738002042	Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349
889738002043	trimer interface [polypeptide binding]; other site
889738002044	active site
889738002045	substrate binding site [chemical binding]; other site
889738002046	CoA binding site [chemical binding]; other site
889738002047	transcription elongation factor GreA; Reviewed; Region: greA; PRK00226
889738002048	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
889738002049	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
889738002050	carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294
889738002051	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
889738002052	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
889738002053	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
889738002054	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
889738002055	ATP-grasp domain; Region: ATP-grasp_4; cl17255
889738002056	Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424
889738002057	IMP binding site; other site
889738002058	dimer interface [polypeptide binding]; other site
889738002059	interdomain contacts; other site
889738002060	partial ornithine binding site; other site
889738002061	carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564
889738002062	Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097
889738002063	Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744
889738002064	catalytic site [active]
889738002065	subunit interface [polypeptide binding]; other site
889738002066	Domon-like domain of UDP-N-acetylenolpyruvoylglucosamine reductase; Region: DOMON_murB_like; cd09627
889738002067	putative heme binding site [chemical binding]; other site
889738002068	Escherichia coli YhbY is associated with pre-50S ribosomal subunits, which implies a function in ribosome assembly; Region: CRS1_YhbY; smart01103
889738002069	FtsJ-like methyltransferase; Region: FtsJ; cl17430
889738002070	23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293
889738002071	FtsH Extracellular; Region: FtsH_ext; pfam06480
889738002072	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
889738002073	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
889738002074	Walker A motif; other site
889738002075	ATP binding site [chemical binding]; other site
889738002076	Walker B motif; other site
889738002077	arginine finger; other site
889738002078	Peptidase family M41; Region: Peptidase_M41; pfam01434
889738002079	DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
889738002080	dihydropteroate synthase; Region: DHPS; TIGR01496
889738002081	substrate binding pocket [chemical binding]; other site
889738002082	dimer interface [polypeptide binding]; other site
889738002083	inhibitor binding site; inhibition site
889738002084	PhoD-like phosphatase; Region: PhoD; pfam09423
889738002085	Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389
889738002086	putative active site [active]
889738002087	putative metal binding site [ion binding]; other site
889738002088	Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389
889738002089	bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14192
889738002090	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
889738002091	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
889738002092	homodimer interface [polypeptide binding]; other site
889738002093	NADP binding site [chemical binding]; other site
889738002094	substrate binding site [chemical binding]; other site
889738002095	Predicted methyltransferase [General function prediction only]; Region: COG3897
889738002096	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
889738002097	S-adenosylmethionine binding site [chemical binding]; other site
889738002098	alpha-ketoglutarate transporter; Provisional; Region: PRK10406
889738002099	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
889738002100	putative substrate translocation pore; other site
889738002101	glycerol kinase; Provisional; Region: glpK; PRK00047
889738002102	Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786
889738002103	N- and C-terminal domain interface [polypeptide binding]; other site
889738002104	active site
889738002105	MgATP binding site [chemical binding]; other site
889738002106	catalytic site [active]
889738002107	metal binding site [ion binding]; metal-binding site
889738002108	glycerol binding site [chemical binding]; other site
889738002109	homotetramer interface [polypeptide binding]; other site
889738002110	homodimer interface [polypeptide binding]; other site
889738002111	FBP binding site [chemical binding]; other site
889738002112	protein IIAGlc interface [polypeptide binding]; other site
889738002113	glycerol-3-phosphate dehydrogenase; Reviewed; Region: glpD; PRK12266
889738002114	Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819
889738002115	active site
889738002116	substrate-binding site [chemical binding]; other site
889738002117	metal-binding site [ion binding]
889738002118	GTP binding site [chemical binding]; other site
889738002119	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
889738002120	Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597
889738002121	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
889738002122	Bacillus subtilis YydB and related proteins, metallophosphatase domain; Region: MPP_YydB; cd07400
889738002123	putative active site [active]
889738002124	putative metal binding site [ion binding]; other site
889738002125	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
889738002126	active site
889738002127	metal binding site [ion binding]; metal-binding site
889738002128	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
889738002129	Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753
889738002130	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
889738002131	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
889738002132	Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753
889738002133	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
889738002134	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
889738002135	type I secretion C-terminal target domain (VC_A0849 subclass); Region: T1SS_VCA0849; TIGR03661
889738002136	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
889738002137	oligomerisation interface [polypeptide binding]; other site
889738002138	mobile loop; other site
889738002139	roof hairpin; other site
889738002140	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
889738002141	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
889738002142	ring oligomerisation interface [polypeptide binding]; other site
889738002143	ATP/Mg binding site [chemical binding]; other site
889738002144	stacking interactions; other site
889738002145	hinge regions; other site
889738002146	Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818
889738002147	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
889738002148	Domain of unknown function (DUF4112); Region: DUF4112; pfam13430
889738002149	heat shock protein HtpX; Provisional; Region: PRK05457
889738002150	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
889738002151	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
889738002152	N-acetyl-D-glucosamine binding site [chemical binding]; other site
889738002153	catalytic residue [active]
889738002154	tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696
889738002155	This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily  includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which  binds to Adenosine group.  This subfamily; Region: Alpha_ANH_like_II; cd01993
889738002156	Ligand Binding Site [chemical binding]; other site
889738002157	SCP-2 sterol transfer family; Region: SCP2; pfam02036
889738002158	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
889738002159	N-acetyl-D-glucosamine binding site [chemical binding]; other site
889738002160	catalytic residue [active]
889738002161	transcription elongation factor GreB; Reviewed; Region: greB; PRK01885
889738002162	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
889738002163	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
889738002164	Calcium/calmodulin dependent protein kinase II Association; Region: CaMKII_AD; cl17504
889738002165	The adenylation (A) domain of siderophore-synthesizing nonribosomal peptide synthetases (NRPS); Region: A_NRPS_SidN3_like; cd05918
889738002166	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
889738002167	acyl-activating enzyme (AAE) consensus motif; other site
889738002168	AMP binding site [chemical binding]; other site
889738002169	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
889738002170	non-ribosomal peptide synthetase terminal domain of unknown function; Region: NRPS_term_dom; TIGR02353
889738002171	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
889738002172	putative trimer interface [polypeptide binding]; other site
889738002173	putative CoA binding site [chemical binding]; other site
889738002174	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
889738002175	putative CoA binding site [chemical binding]; other site
889738002176	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
889738002177	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
889738002178	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
889738002179	Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687
889738002180	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
889738002181	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
889738002182	Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137
889738002183	dimer interface [polypeptide binding]; other site
889738002184	FMN binding site [chemical binding]; other site
889738002185	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
889738002186	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
889738002187	NAD(P) binding site [chemical binding]; other site
889738002188	active site
889738002189	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
889738002190	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
889738002191	Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929
889738002192	oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701
889738002193	The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767
889738002194	putative molybdopterin cofactor binding site [chemical binding]; other site
889738002195	The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787
889738002196	putative molybdopterin cofactor binding site; other site
889738002197	formate dehydrogenase accessory protein; Reviewed; Region: PRK00724
889738002198	Protein of unknown function (DUF1232); Region: DUF1232; cl01318
889738002199	erythronate-4-phosphate dehydrogenase; Validated; Region: PRK00257
889738002200	D-Erythronate-4-Phosphate Dehydrogenase NAD-binding and catalytic domains; Region: ErythrP_dh; cd12158
889738002201	ligand binding site [chemical binding]; other site
889738002202	NAD binding site [chemical binding]; other site
889738002203	catalytic site [active]
889738002204	homodimer interface [polypeptide binding]; other site
889738002205	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
889738002206	EF-P lysine aminoacylase GenX; Region: genX; TIGR00462
889738002207	motif 1; other site
889738002208	dimer interface [polypeptide binding]; other site
889738002209	active site
889738002210	motif 2; other site
889738002211	motif 3; other site
889738002212	DNA repair protein RadA; Provisional; Region: PRK11823
889738002213	Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121
889738002214	Walker A motif/ATP binding site; other site
889738002215	ATP binding site [chemical binding]; other site
889738002216	Walker B motif; other site
889738002217	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
889738002218	D-alanine/D-serine/glycine permease; Provisional; Region: PRK11049
889738002219	diaminopimelate decarboxylase; Region: lysA; TIGR01048
889738002220	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828
889738002221	active site
889738002222	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
889738002223	substrate binding site [chemical binding]; other site
889738002224	catalytic residues [active]
889738002225	dimer interface [polypeptide binding]; other site
889738002226	diaminopimelate epimerase; Provisional; Region: dapF; PRK00450
889738002227	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
889738002228	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
889738002229	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
889738002230	site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236
889738002231	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
889738002232	active site
889738002233	DNA binding site [nucleotide binding]
889738002234	Int/Topo IB signature motif; other site
889738002235	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714
889738002236	Ligand binding site [chemical binding]; other site
889738002237	Electron transfer flavoprotein domain; Region: ETF; pfam01012
889738002238	electron transfer flavoprotein subunit alpha; Provisional; Region: PLN00022
889738002239	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715
889738002240	Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766
889738002241	DNA gyrase subunit A; Validated; Region: PRK05560
889738002242	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
889738002243	CAP-like domain; other site
889738002244	active site
889738002245	primary dimer interface [polypeptide binding]; other site
889738002246	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
889738002247	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
889738002248	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
889738002249	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
889738002250	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
889738002251	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
889738002252	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807
889738002253	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364
889738002254	GtrA-like protein; Region: GtrA; pfam04138
889738002255	undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714
889738002256	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
889738002257	Ligand binding site; other site
889738002258	Putative Catalytic site; other site
889738002259	DXD motif; other site
889738002260	uncharacterized YdjC-like family proteins from bacteria; Region: YdjC_like_3; cd10807
889738002261	putative active site [active]
889738002262	YdjC motif; other site
889738002263	Mg binding site [ion binding]; other site
889738002264	putative homodimer interface [polypeptide binding]; other site
889738002265	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
889738002266	ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698
889738002267	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
889738002268	ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698
889738002269	Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566
889738002270	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
889738002271	HlyD family secretion protein; Region: HlyD_3; pfam13437
889738002272	Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538
889738002273	Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT).  PSAT is active as...; Region: PSAT_like; cd00611
889738002274	homodimer interface [polypeptide binding]; other site
889738002275	substrate-cofactor binding pocket; other site
889738002276	pyridoxal 5'-phosphate binding site [chemical binding]; other site
889738002277	catalytic residue [active]
889738002278	Uncharacterized BCR, YaiI/YqxD family COG1671; Region: DUF188; pfam02639
889738002279	putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272
889738002280	EamA-like transporter family; Region: EamA; pfam00892
889738002281	lipoprotein releasing system, transmembrane protein, LolC/E family; Region: lolCE; TIGR02212
889738002282	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
889738002283	FtsX-like permease family; Region: FtsX; pfam02687
889738002284	lipoprotein releasing system, ATP-binding protein; Region: LolD_lipo_ex; TIGR02211
889738002285	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
889738002286	Walker A/P-loop; other site
889738002287	ATP binding site [chemical binding]; other site
889738002288	Q-loop/lid; other site
889738002289	ABC transporter signature motif; other site
889738002290	Walker B; other site
889738002291	D-loop; other site
889738002292	H-loop/switch region; other site
889738002293	Domain of unknown function (DUF4131); Region: DUF4131; pfam13567
889738002294	Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658
889738002295	Competence protein; Region: Competence; pfam03772
889738002296	Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333
889738002297	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
889738002298	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
889738002299	putative acyl-acceptor binding pocket; other site
889738002300	Periplasmic serine proteases (ClpP class) [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: SppA; COG0616
889738002301	Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023
889738002302	tandem repeat interface [polypeptide binding]; other site
889738002303	oligomer interface [polypeptide binding]; other site
889738002304	active site residues [active]
889738002305	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
889738002306	phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647
889738002307	Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645
889738002308	active site
889738002309	substrate binding site [chemical binding]; other site
889738002310	cosubstrate binding site; other site
889738002311	catalytic site [active]
889738002312	phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385
889738002313	PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196
889738002314	dimerization interface [polypeptide binding]; other site
889738002315	putative ATP binding site [chemical binding]; other site
889738002316	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
889738002317	Domain of unknown function DUF20; Region: UPF0118; pfam01594
889738002318	ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593
889738002319	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
889738002320	Walker A motif; other site
889738002321	ATP binding site [chemical binding]; other site
889738002322	Walker B motif; other site
889738002323	arginine finger; other site
889738002324	Acinetobacter rhombotarget A; Region: GlyGly_RbtA; TIGR04212
889738002325	CSLREA domain; Region: CSLREA_Nterm; TIGR04214
889738002326	Acinetobacter rhombotarget A; Region: GlyGly_RbtA; TIGR04212
889738002327	CSLREA domain; Region: CSLREA_Nterm; TIGR04214
889738002328	Protein of unknown function (DUF3106); Region: DUF3106; pfam11304
889738002329	RNA polymerase factor sigma-70; Validated; Region: PRK09047
889738002330	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
889738002331	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
889738002332	DNA binding residues [nucleotide binding]
889738002333	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
889738002334	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
889738002335	fructose-1,6-bisphosphatase family protein; Region: PLN02628
889738002336	Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate  into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354
889738002337	AMP binding site [chemical binding]; other site
889738002338	metal binding site [ion binding]; metal-binding site
889738002339	active site
889738002340	putative outer membrane lipoprotein; Provisional; Region: PRK09967
889738002341	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
889738002342	ligand binding site [chemical binding]; other site
889738002343	translocation protein TolB; Provisional; Region: tolB; PRK04922
889738002344	TolB amino-terminal domain; Region: TolB_N; pfam04052
889738002345	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
889738002346	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
889738002347	TolA protein; Region: tolA_full; TIGR02794
889738002348	TonB C terminal; Region: TonB_2; pfam13103
889738002349	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
889738002350	TolR protein; Region: tolR; TIGR02801
889738002351	TolQ protein; Region: tolQ; TIGR02796
889738002352	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
889738002353	active site
889738002354	M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like2; cd05667
889738002355	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
889738002356	metal binding site [ion binding]; metal-binding site
889738002357	putative dimer interface [polypeptide binding]; other site
889738002358	Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080
889738002359	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078
889738002360	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
889738002361	Walker A motif; other site
889738002362	ATP binding site [chemical binding]; other site
889738002363	Walker B motif; other site
889738002364	arginine finger; other site
889738002365	Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491
889738002366	Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116
889738002367	RuvA N terminal domain; Region: RuvA_N; pfam01330
889738002368	RuvA, C-terminal domain; Region: RuvA_C; pfam07499
889738002369	deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01096
889738002370	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
889738002371	Zn2+ binding site [ion binding]; other site
889738002372	Mg2+ binding site [ion binding]; other site
889738002373	phosphoribosylformylglycinamidine synthase; Provisional; Region: PRK05297
889738002374	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203
889738002375	dimerization interface [polypeptide binding]; other site
889738002376	ATP binding site [chemical binding]; other site
889738002377	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204
889738002378	dimerization interface [polypeptide binding]; other site
889738002379	ATP binding site [chemical binding]; other site
889738002380	Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740
889738002381	putative active site [active]
889738002382	catalytic triad [active]
889738002383	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
889738002384	putative substrate translocation pore; other site
889738002385	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323
889738002386	enoyl-CoA hydratase; Provisional; Region: PRK06688
889738002387	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
889738002388	substrate binding site [chemical binding]; other site
889738002389	oxyanion hole (OAH) forming residues; other site
889738002390	trimer interface [polypeptide binding]; other site
889738002391	nicotinamide-nucleotide adenylyltransferase; Provisional; Region: PRK13793
889738002392	active site
889738002393	nucleotide binding site [chemical binding]; other site
889738002394	HIGH motif; other site
889738002395	KMSKS motif; other site
889738002396	Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340
889738002397	SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379
889738002398	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
889738002399	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
889738002400	catalytic triad [active]
889738002401	Predicted ATPases of PP-loop superfamily [General function prediction only]; Region: COG2102
889738002402	This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily  includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which  binds to Adenosine group.  This subfamily; Region: Alpha_ANH_like_IV; cd01994
889738002403	Ligand Binding Site [chemical binding]; other site
889738002404	ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995
889738002405	Ligand Binding Site [chemical binding]; other site
889738002406	putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE, gammaproteobacterial type; Region: rSAM_QueE_gams; TIGR04349
889738002407	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
889738002408	FeS/SAM binding site; other site
889738002409	2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830
889738002410	2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350
889738002411	active site
889738002412	substrate binding site [chemical binding]; other site
889738002413	trimer interface [polypeptide binding]; other site
889738002414	CoA binding site [chemical binding]; other site
889738002415	transcriptional regulator CysB-like protein; Reviewed; Region: PRK12683
889738002416	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
889738002417	The C-terminal substrate domain of LysR-type transcriptional regulators CysB-like contains type 2 periplasmic binding fold; Region: PBP2_CysB_like; cd08413
889738002418	substrate binding site [chemical binding]; other site
889738002419	dimerization interface [polypeptide binding]; other site
889738002420	ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118
889738002421	ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296
889738002422	Walker A/P-loop; other site
889738002423	ATP binding site [chemical binding]; other site
889738002424	Q-loop/lid; other site
889738002425	ABC transporter signature motif; other site
889738002426	Walker B; other site
889738002427	D-loop; other site
889738002428	H-loop/switch region; other site
889738002429	TOBE-like domain; Region: TOBE_3; pfam12857
889738002430	sulfate transport protein; Provisional; Region: cysT; CHL00187
889738002431	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
889738002432	dimer interface [polypeptide binding]; other site
889738002433	conserved gate region; other site
889738002434	putative PBP binding loops; other site
889738002435	ABC-ATPase subunit interface; other site
889738002436	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
889738002437	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
889738002438	dimer interface [polypeptide binding]; other site
889738002439	conserved gate region; other site
889738002440	putative PBP binding loops; other site
889738002441	ABC-ATPase subunit interface; other site
889738002442	Serine hydrolase; Region: Ser_hydrolase; pfam06821
889738002443	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
889738002444	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
889738002445	substrate binding pocket [chemical binding]; other site
889738002446	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
889738002447	membrane-bound complex binding site; other site
889738002448	hinge residues; other site
889738002449	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
889738002450	ADCL_like: 4-Amino-4-deoxychorismate lyase:  is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate.  Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559
889738002451	pyridoxal 5'-phosphate binding site [chemical binding]; other site
889738002452	catalytic residue [active]
889738002453	YceG-like family; Region: YceG; pfam02618
889738002454	proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010
889738002455	dimerization interface [polypeptide binding]; other site
889738002456	Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672
889738002457	thymidylate kinase; Validated; Region: tmk; PRK00698
889738002458	TMP-binding site; other site
889738002459	ATP-binding site [chemical binding]; other site
889738002460	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
889738002461	CoenzymeA binding site [chemical binding]; other site
889738002462	subunit interaction site [polypeptide binding]; other site
889738002463	PHB binding site; other site
889738002464	L-aspartate oxidase; Provisional; Region: PRK09077
889738002465	L-aspartate oxidase; Provisional; Region: PRK06175
889738002466	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
889738002467	periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037
889738002468	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
889738002469	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
889738002470	protein binding site [polypeptide binding]; other site
889738002471	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
889738002472	protein binding site [polypeptide binding]; other site
889738002473	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
889738002474	active site
889738002475	GTP-binding protein LepA; Provisional; Region: PRK05433
889738002476	LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890
889738002477	G1 box; other site
889738002478	putative GEF interaction site [polypeptide binding]; other site
889738002479	GTP/Mg2+ binding site [chemical binding]; other site
889738002480	Switch I region; other site
889738002481	G2 box; other site
889738002482	G3 box; other site
889738002483	Switch II region; other site
889738002484	G4 box; other site
889738002485	G5 box; other site
889738002486	lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699
889738002487	lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane.   LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709
889738002488	GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421
889738002489	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
889738002490	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
889738002491	Catalytic site [active]
889738002492	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
889738002493	ribonuclease III; Reviewed; Region: rnc; PRK00102
889738002494	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
889738002495	dimerization interface [polypeptide binding]; other site
889738002496	active site
889738002497	metal binding site [ion binding]; metal-binding site
889738002498	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048
889738002499	dsRNA binding site [nucleotide binding]; other site
889738002500	GTPase Era; Reviewed; Region: era; PRK00089
889738002501	E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163
889738002502	G1 box; other site
889738002503	GTP/Mg2+ binding site [chemical binding]; other site
889738002504	Switch I region; other site
889738002505	G2 box; other site
889738002506	Switch II region; other site
889738002507	G3 box; other site
889738002508	G4 box; other site
889738002509	G5 box; other site
889738002510	KH domain; Region: KH_2; pfam07650
889738002511	DNA repair protein RecO; Reviewed; Region: recO; PRK00085
889738002512	Recombination protein O N terminal; Region: RecO_N; pfam11967
889738002513	Recombination protein O C terminal; Region: RecO_C; pfam02565
889738002514	Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003
889738002515	active site
889738002516	hydrophilic channel; other site
889738002517	dimerization interface [polypeptide binding]; other site
889738002518	catalytic residues [active]
889738002519	active site lid [active]
889738002520	MiaE tRNA-modifying nonheme diiron monooxygenase, ferritin-like diiron-binding domain; Region: MiaE; cd07910
889738002521	active site
889738002522	dinuclear metal binding site [ion binding]; other site
889738002523	dimerization interface [polypeptide binding]; other site
889738002524	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
889738002525	malonic semialdehyde reductase; Provisional; Region: PRK10538
889738002526	NAD(P) binding site [chemical binding]; other site
889738002527	active site
889738002528	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
889738002529	CoenzymeA binding site [chemical binding]; other site
889738002530	subunit interaction site [polypeptide binding]; other site
889738002531	PHB binding site; other site
889738002532	Uncharacterized conserved protein [Function unknown]; Region: COG3791
889738002533	aspartate aminotransferase; Provisional; Region: PRK05764
889738002534	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
889738002535	pyridoxal 5'-phosphate binding site [chemical binding]; other site
889738002536	homodimer interface [polypeptide binding]; other site
889738002537	catalytic residue [active]
889738002538	PAS domain; Region: PAS_9; pfam13426
889738002539	PAS domain; Region: PAS_9; pfam13426
889738002540	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
889738002541	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
889738002542	metal binding site [ion binding]; metal-binding site
889738002543	active site
889738002544	I-site; other site
889738002545	hypothetical protein; Region: PHA00684
889738002546	excinuclease ABC subunit B; Provisional; Region: PRK05298
889738002547	Myosin and Kinesin motor domain. These ATPases belong to the P-loop NTPase family and provide the driving force in myosin and kinesin mediated processes; Region: Motor_domain; cl00286
889738002548	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
889738002549	ATP-binding site [chemical binding]; other site
889738002550	ATP binding site [chemical binding]; other site
889738002551	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
889738002552	nucleotide binding region [chemical binding]; other site
889738002553	ATP-binding site [chemical binding]; other site
889738002554	Ultra-violet resistance protein B; Region: UvrB; pfam12344
889738002555	UvrB/uvrC motif; Region: UVR; pfam02151
889738002556	Bacterial lipocalin [Cell envelope biogenesis, outer membrane]; Region: Blc; COG3040
889738002557	Lipocalin-like domain; Region: Lipocalin_2; pfam08212
889738002558	Predicted permeases [General function prediction only]; Region: RarD; COG2962
889738002559	glyceraldehyde-3-phosphate dehydrogenase; Reviewed; Region: PRK08289
889738002560	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846
889738002561	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
889738002562	GTPase CgtA; Reviewed; Region: obgE; PRK12298
889738002563	GTP1/OBG; Region: GTP1_OBG; pfam01018
889738002564	Obg GTPase; Region: Obg; cd01898
889738002565	G1 box; other site
889738002566	GTP/Mg2+ binding site [chemical binding]; other site
889738002567	Switch I region; other site
889738002568	G2 box; other site
889738002569	G3 box; other site
889738002570	Switch II region; other site
889738002571	G4 box; other site
889738002572	G5 box; other site
889738002573	gamma-glutamyl kinase; Provisional; Region: PRK05429
889738002574	AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242
889738002575	nucleotide binding site [chemical binding]; other site
889738002576	homotetrameric interface [polypeptide binding]; other site
889738002577	putative phosphate binding site [ion binding]; other site
889738002578	putative allosteric binding site; other site
889738002579	PUA domain; Region: PUA; pfam01472
889738002580	Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560
889738002581	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
889738002582	Protein of unknown function (DUF1615); Region: DUF1615; pfam07759
889738002583	Pyocin activator protein PrtN; Region: PyocinActivator; pfam11112
889738002584	Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420
889738002585	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
889738002586	active site
889738002587	catalytic site [active]
889738002588	substrate binding site [chemical binding]; other site
889738002589	ERF superfamily; Region: ERF; pfam04404
889738002590	Predicted transcriptional regulator [Transcription]; Region: COG2932
889738002591	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
889738002592	Catalytic site [active]
889738002593	Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which  binds to Adenosine nucleotide; Region: AANH_like; cl00292
889738002594	Ligand Binding Site [chemical binding]; other site
889738002595	Bacteriophage replication protein O; Region: Phage_rep_O; cl04545
889738002596	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
889738002597	Active Sites [active]
889738002598	HNH nucleases; Region: HNHc; smart00507
889738002599	active site
889738002600	Protein of unknown function (DUF1064); Region: DUF1064; pfam06356
889738002601	membrane glycoprotein; Provisional; Region: PHA03332
889738002602	Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dam; COG0338
889738002603	Uncharacterized conserved protein (DUF2280); Region: DUF2280; pfam10045
889738002604	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5410
889738002605	Terminase-like family; Region: Terminase_6; pfam03237
889738002606	Phage-related terminase [General function prediction only]; Region: COG5362; cl02216
889738002607	Domain of unknown function (DUF4055); Region: DUF4055; pfam13264
889738002608	Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072
889738002609	Phage protein (N4 Gp49/phage Sf6 gene 66) family; Region: Phage_gp49_66; pfam13876
889738002610	Putative stress-responsive nuclear envelope protein; Region: Ish1; pfam10281
889738002611	YcfA-like protein; Region: YcfA; pfam07927
889738002612	Predicted nuclease of the RNAse H fold, HicB family [General    function prediction only]; Region: COG1598
889738002613	Phage-related minor tail protein [Function unknown]; Region: COG5281
889738002614	tape measure domain; Region: tape_meas_nterm; TIGR02675
889738002615	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
889738002616	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
889738002617	N-acetyl-D-glucosamine binding site [chemical binding]; other site
889738002618	catalytic residue [active]
889738002619	Phage minor tail protein; Region: Phage_min_tail; cl01940
889738002620	Phage minor tail protein L; Region: Phage_tail_L; cl01908
889738002621	Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding) found in proteins also containing NlpC/P60 domains; Region: MPN_NLPC_P60; cd08073
889738002622	MPN+ (JAMM) motif; other site
889738002623	Zinc-binding site [ion binding]; other site
889738002624	NlpC/P60 family; Region: NLPC_P60; cl17555
889738002625	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
889738002626	Phage-related protein, tail component [Function unknown]; Region: COG4723
889738002627	Phage-related protein, tail component [Function unknown]; Region: COG4723
889738002628	Phage-related protein, tail component [Function unknown]; Region: COG4733
889738002629	Putative phage tail protein; Region: Phage-tail_3; pfam13550
889738002630	Baculovirus polyhedron envelope protein, PEP, C terminus; Region: Baculo_PEP_C; pfam04513
889738002631	Lysis protein S; Region: Lysis_S; pfam04971
889738002632	Glycosyl hydrolase 108; Region: Glyco_hydro_108; pfam05838
889738002633	Predicted Peptidoglycan domain; Region: PG_binding_3; pfam09374
889738002634	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
889738002635	active site
889738002636	DNA binding site [nucleotide binding]
889738002637	Int/Topo IB signature motif; other site
889738002638	putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737
889738002639	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
889738002640	FMN binding site [chemical binding]; other site
889738002641	active site
889738002642	catalytic residues [active]
889738002643	substrate binding site [chemical binding]; other site
889738002644	Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070
889738002645	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
889738002646	FMN binding site [chemical binding]; other site
889738002647	substrate binding site [chemical binding]; other site
889738002648	putative catalytic residue [active]
889738002649	Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_1; cd02432
889738002650	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
889738002651	TPR motif; other site
889738002652	binding surface
889738002653	UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381
889738002654	Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase  family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786
889738002655	active site
889738002656	homodimer interface [polypeptide binding]; other site
889738002657	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
889738002658	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
889738002659	CESA_like is  the cellulose synthase superfamily; Region: CESA_like; cd06423
889738002660	DXD motif; other site
889738002661	Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415
889738002662	DNA photolyase; Region: DNA_photolyase; pfam00875
889738002663	FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095
889738002664	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
889738002665	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
889738002666	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
889738002667	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
889738002668	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768
889738002669	Predicted protease with the C-terminal PDZ domain [General function prediction only]; Region: COG3975
889738002670	M61 glycyl aminopeptidase; Region: Peptidase_M61; pfam05299
889738002671	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
889738002672	Monomeric isocitrate dehydrogenase [Energy production and conversion]; Region: Icd; COG2838
889738002673	Monomeric isocitrate dehydrogenase; Region: IDH; cl15383
889738002674	Pseudouridine synthase, Escherichia coli RluE; Region: PseudoU_synth_RluE; cd02566
889738002675	pseudouridine synthase; Region: TIGR00093
889738002676	probable active site [active]
889738002677	isocitrate dehydrogenase; Validated; Region: PRK06451
889738002678	isocitrate dehydrogenase; Reviewed; Region: PRK07006
889738002679	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
889738002680	Major Facilitator Superfamily; Region: MFS_1; pfam07690
889738002681	putative substrate translocation pore; other site
889738002682	Transcriptional regulator [Transcription]; Region: LysR; COG0583
889738002683	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
889738002684	The C-terminal substrate binding domain of LysR-type transcriptional regulators, YofA and SoxR, contains the type 2 periplasmic binding fold; Region: PBP2_YofA_SoxR_like; cd08442
889738002685	putative dimerization interface [polypeptide binding]; other site
889738002686	Predicted Na+/dicarboxylate symporter [General function prediction only]; Region: COG1823
889738002687	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
889738002688	Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384
889738002689	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
889738002690	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
889738002691	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
889738002692	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
889738002693	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
889738002694	Protein of unknown function (DUF3144); Region: DUF3144; pfam11342
889738002695	Uncharacterized conserved protein [Function unknown]; Region: COG3025
889738002696	Uncharacterized subgroup of the CYTH-like superfamily having an associated CHAD domain; Region: CYTH-like_Pase_CHAD; cd07756
889738002697	putative active site [active]
889738002698	putative metal binding residues [ion binding]; other site
889738002699	signature motif; other site
889738002700	putative triphosphate binding site [ion binding]; other site
889738002701	The CHAD domain is an alpha-helical domain functionally associated with some members of the adenylate cyclase family; Region: CHAD; smart00880
889738002702	Protein of unknown function (DUF962); Region: DUF962; pfam06127
889738002703	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
889738002704	thiamine phosphate binding site [chemical binding]; other site
889738002705	active site
889738002706	pyrophosphate binding site [ion binding]; other site
889738002707	glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062
889738002708	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
889738002709	inhibitor-cofactor binding pocket; inhibition site
889738002710	pyridoxal 5'-phosphate binding site [chemical binding]; other site
889738002711	catalytic residue [active]
889738002712	Phosphopantetheine attachment site; Region: PP-binding; cl09936
889738002713	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
889738002714	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
889738002715	active site
889738002716	ATP-dependent helicase HepA; Validated; Region: PRK04914
889738002717	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
889738002718	ATP binding site [chemical binding]; other site
889738002719	putative Mg++ binding site [ion binding]; other site
889738002720	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
889738002721	nucleotide binding region [chemical binding]; other site
889738002722	ATP-binding site [chemical binding]; other site
889738002723	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465
889738002724	DNA-binding transcriptional repressor FabR; Provisional; Region: PRK11202
889738002725	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
889738002726	Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_2; cd06216
889738002727	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
889738002728	FAD binding pocket [chemical binding]; other site
889738002729	FAD binding motif [chemical binding]; other site
889738002730	phosphate binding motif [ion binding]; other site
889738002731	beta-alpha-beta structure motif; other site
889738002732	NAD binding pocket [chemical binding]; other site
889738002733	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
889738002734	catalytic loop [active]
889738002735	iron binding site [ion binding]; other site
889738002736	Fatty acid desaturase; Region: FA_desaturase; pfam00487
889738002737	The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506
889738002738	putative di-iron ligands [ion binding]; other site
889738002739	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
889738002740	CoenzymeA binding site [chemical binding]; other site
889738002741	subunit interaction site [polypeptide binding]; other site
889738002742	PHB binding site; other site
889738002743	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
889738002744	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
889738002745	Protein of unknown function (DUF541); Region: SIMPL; cl01077
889738002746	diaminobutyrate--2-oxoglutarate aminotransferase; Provisional; Region: PRK06931
889738002747	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
889738002748	inhibitor-cofactor binding pocket; inhibition site
889738002749	pyridoxal 5'-phosphate binding site [chemical binding]; other site
889738002750	catalytic residue [active]
889738002751	DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450
889738002752	pyridoxal 5'-phosphate binding site [chemical binding]; other site
889738002753	catalytic residue [active]
889738002754	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
889738002755	Streptomyces aureofaciens putative aldehyde dehydrogenase AldA (AAD23400)-like; Region: ALDH_AldA-AAD23400; cd07106
889738002756	NAD(P) binding site [chemical binding]; other site
889738002757	catalytic residues [active]
889738002758	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
889738002759	AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404
889738002760	AsnC family; Region: AsnC_trans_reg; pfam01037
889738002761	Pyruvate decarboxylase and related thiamine pyrophosphate-requiring enzymes [Carbohydrate transport and metabolism / Coenzyme metabolism / General function prediction only]; Region: COG3961
889738002762	Pyrimidine (PYR) binding domain of pyruvate decarboxylase (PDC), indolepyruvate decarboxylase (IPDC) and related proteins; Region: TPP_PYR_PDC_IPDC_like; cd07038
889738002763	dimer interface [polypeptide binding]; other site
889738002764	PYR/PP interface [polypeptide binding]; other site
889738002765	TPP binding site [chemical binding]; other site
889738002766	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
889738002767	Thiamine pyrophosphate (TPP) family, PDC_IPDC subfamily, TPP-binding module; composed of proteins similar to pyruvate decarboxylase (PDC) and indolepyruvate decarboxylase (IPDC). PDC, a key enzyme in alcoholic fermentation, catalyzes the conversion of...; Region: TPP_PDC_IPDC; cd02005
889738002768	TPP-binding site [chemical binding]; other site
889738002769	dimer interface [polypeptide binding]; other site
889738002770	aromatic amino acid transporter; Provisional; Region: PRK10238
889738002771	ABC-type phosphate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PstS; COG0226
889738002772	Phosphate ATP-binding cassette transporter; Region: DUF3708; pfam12501
889738002773	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573
889738002774	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
889738002775	dimer interface [polypeptide binding]; other site
889738002776	conserved gate region; other site
889738002777	putative PBP binding loops; other site
889738002778	ABC-ATPase subunit interface; other site
889738002779	Domain of unknown function (DUF3333); Region: DUF3333; pfam11812
889738002780	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581
889738002781	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
889738002782	dimer interface [polypeptide binding]; other site
889738002783	conserved gate region; other site
889738002784	putative PBP binding loops; other site
889738002785	ABC-ATPase subunit interface; other site
889738002786	phosphate transporter ATP-binding protein; Provisional; Region: PRK14235
889738002787	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
889738002788	Walker A/P-loop; other site
889738002789	ATP binding site [chemical binding]; other site
889738002790	Q-loop/lid; other site
889738002791	ABC transporter signature motif; other site
889738002792	Walker B; other site
889738002793	D-loop; other site
889738002794	H-loop/switch region; other site
889738002795	signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706
889738002796	Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023
889738002797	tandem repeat interface [polypeptide binding]; other site
889738002798	oligomer interface [polypeptide binding]; other site
889738002799	active site residues [active]
889738002800	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
889738002801	Predicted membrane protein (DUF2238); Region: DUF2238; pfam09997
889738002802	adenylosuccinate lyase; Provisional; Region: PRK09285
889738002803	PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598
889738002804	tetramer interface [polypeptide binding]; other site
889738002805	active site
889738002806	putative lysogenization regulator; Reviewed; Region: PRK00218
889738002807	Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482
889738002808	tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998
889738002809	Contains a crystal structure of the Nudix hydrolase from Nitrosomonas europaea, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_2; cd03675
889738002810	nudix motif; other site
889738002811	Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663
889738002812	Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645
889738002813	trimer interface [polypeptide binding]; other site
889738002814	putative metal binding site [ion binding]; other site
889738002815	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
889738002816	D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686
889738002817	Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936
889738002818	5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346
889738002819	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
889738002820	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
889738002821	Peptidase family M23; Region: Peptidase_M23; pfam01551
889738002822	Transcriptional regulator [Transcription]; Region: LysR; COG0583
889738002823	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
889738002824	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
889738002825	putative effector binding pocket; other site
889738002826	dimerization interface [polypeptide binding]; other site
889738002827	AAA domain; Region: AAA_32; pfam13654
889738002828	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cl00148
889738002829	primary dimer interface [polypeptide binding]; other site
889738002830	lon-related putative ATP-dependent protease; Region: lon_rel; TIGR00764
889738002831	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
889738002832	muropeptide transporter; Validated; Region: ampG; cl17669
889738002833	muropeptide transporter; Validated; Region: ampG; cl17669
889738002834	muropeptide transporter; Validated; Region: ampG; cl17669
889738002835	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
889738002836	Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233
889738002837	dimer interface [polypeptide binding]; other site
889738002838	active site
889738002839	metal binding site [ion binding]; metal-binding site
889738002840	glutathione binding site [chemical binding]; other site
889738002841	Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385
889738002842	SBF-like CPA transporter family (DUF4137); Region: DUF4137; pfam13593
889738002843	50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019
889738002844	PAS domain S-box; Region: sensory_box; TIGR00229
889738002845	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cl00290
889738002846	Radical SAM superfamily; Region: Radical_SAM; pfam04055
889738002847	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
889738002848	FeS/SAM binding site; other site
889738002849	elongation factor P; Validated; Region: PRK00529
889738002850	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
889738002851	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
889738002852	RNA binding site [nucleotide binding]; other site
889738002853	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
889738002854	RNA binding site [nucleotide binding]; other site
889738002855	carbon starvation protein A; Provisional; Region: PRK15015
889738002856	Carbon starvation protein CstA; Region: CstA; pfam02554
889738002857	C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722
889738002858	Protein of unknown function (DUF466); Region: DUF466; pfam04328
889738002859	Phage antirepressor protein KilAC domain; Region: ANT; cl01462
889738002860	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
889738002861	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
889738002862	Purine catabolism regulatory protein-like family; Region: PucR; pfam07905
889738002863	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
889738002864	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
889738002865	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
889738002866	Protein of unknown function (DUF861); Region: Cupin_3; pfam05899
889738002867	Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085
889738002868	methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722
889738002869	tetrameric interface [polypeptide binding]; other site
889738002870	NAD binding site [chemical binding]; other site
889738002871	catalytic residues [active]
889738002872	Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113
889738002873	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
889738002874	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
889738002875	The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432
889738002876	dimerization interface [polypeptide binding]; other site
889738002877	substrate binding pocket [chemical binding]; other site
889738002878	BCCT family transporter; Region: BCCT; pfam02028
889738002879	BCCT family transporter; Region: BCCT; pfam02028
889738002880	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
889738002881	Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469
889738002882	[2Fe-2S] cluster binding site [ion binding]; other site
889738002883	C-terminal catalytic domain of the oxygenase alpha subunit of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C; cd00680
889738002884	alpha subunit interface [polypeptide binding]; other site
889738002885	active site
889738002886	substrate binding site [chemical binding]; other site
889738002887	Fe binding site [ion binding]; other site
889738002888	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
889738002889	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
889738002890	NAD(P) binding site [chemical binding]; other site
889738002891	catalytic residues [active]
889738002892	Rubredoxin [Energy production and conversion]; Region: COG1773
889738002893	Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730
889738002894	iron binding site [ion binding]; other site
889738002895	NADH:flavorubredoxin oxidoreductase; Provisional; Region: PRK04965
889738002896	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
889738002897	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
889738002898	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
889738002899	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
889738002900	ethanolamine utilization protein EutQ; Provisional; Region: PRK15457
889738002901	Multiple antibiotic transporter [Intracellular trafficking and secretion]; Region: MarC; COG2095
889738002902	aromatic amino acid exporter; Provisional; Region: PRK11689
889738002903	EamA-like transporter family; Region: EamA; pfam00892
889738002904	EamA-like transporter family; Region: EamA; pfam00892
889738002905	Antitoxin of toxin-antitoxin stability system N-terminal; Region: RelB_N; pfam12910
889738002906	Sugar (and other) transporter; Region: Sugar_tr; pfam00083
889738002907	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
889738002908	putative substrate translocation pore; other site
889738002909	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
889738002910	L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948
889738002911	Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188
889738002912	metal binding site [ion binding]; metal-binding site
889738002913	substrate binding pocket [chemical binding]; other site
889738002914	Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR9; cd08274
889738002915	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
889738002916	putative NAD(P) binding site [chemical binding]; other site
889738002917	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
889738002918	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
889738002919	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
889738002920	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
889738002921	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
889738002922	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
889738002923	Pirin-related protein [General function prediction only]; Region: COG1741
889738002924	Pirin; Region: Pirin; pfam02678
889738002925	Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342
889738002926	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
889738002927	Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342
889738002928	catalytic residue [active]
889738002929	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964
889738002930	YheO-like PAS domain; Region: PAS_6; pfam08348
889738002931	HTH domain; Region: HTH_22; pfam13309
889738002932	Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375
889738002933	Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193
889738002934	FAD binding pocket [chemical binding]; other site
889738002935	FAD binding motif [chemical binding]; other site
889738002936	phosphate binding motif [ion binding]; other site
889738002937	NAD binding pocket [chemical binding]; other site
889738002938	The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; Region: A_NRPS_TlmIV_like; cd12114
889738002939	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
889738002940	acyl-activating enzyme (AAE) consensus motif; other site
889738002941	AMP binding site [chemical binding]; other site
889738002942	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
889738002943	Condensation domain; Region: Condensation; pfam00668
889738002944	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
889738002945	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
889738002946	ABC-ATPase subunit  interface; other site
889738002947	dimer interface [polypeptide binding]; other site
889738002948	putative PBP binding regions; other site
889738002949	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
889738002950	ABC-ATPase subunit  interface; other site
889738002951	dimer interface [polypeptide binding]; other site
889738002952	putative PBP binding regions; other site
889738002953	ABC-type enterochelin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CeuD; COG4604
889738002954	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
889738002955	Walker A/P-loop; other site
889738002956	ATP binding site [chemical binding]; other site
889738002957	Q-loop/lid; other site
889738002958	ABC transporter signature motif; other site
889738002959	Walker B; other site
889738002960	D-loop; other site
889738002961	H-loop/switch region; other site
889738002962	ABC-type enterochelin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: CeuA; COG4607
889738002963	Siderophore binding protein FatB.  These proteins have been shown to function as ABC-type initial receptors in the siderophore-mediated iron uptake in some eubacterial species.  They belong to the TroA superfamily of periplasmic metal binding proteins...; Region: FatB; cd01140
889738002964	putative ligand binding residues [chemical binding]; other site
889738002965	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
889738002966	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
889738002967	N-terminal plug; other site
889738002968	ligand-binding site [chemical binding]; other site
889738002969	Lysine/ornithine N-monooxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: IucD; COG3486
889738002970	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
889738002971	Condensation domain; Region: Condensation; pfam00668
889738002972	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
889738002973	Nonribosomal peptide synthase; Region: NRPS; pfam08415
889738002974	Condensation domain; Region: Condensation; pfam00668
889738002975	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
889738002976	Nonribosomal peptide synthase; Region: NRPS; pfam08415
889738002977	enterobactin synthase subunit E; Provisional; Region: entE; PRK10946
889738002978	2,3-dihydroxybenzoate-AMP ligase; Region: 23DHB-AMP_lg; cd05920
889738002979	acyl-activating enzyme (AAE) consensus motif; other site
889738002980	active site
889738002981	AMP binding site [chemical binding]; other site
889738002982	substrate binding site [chemical binding]; other site
889738002983	Isochorismatase, also known as 2,3 dihydro-2,3 dihydroxybenzoate synthase, catalyses the conversion of isochorismate, in the presence of water, to 2,3-dihydroxybenzoate and pyruvate, via the hydrolysis of a vinyl ether, an uncommon reaction in biological...; Region: isochorismatase; cd01013
889738002984	hydrophobic substrate binding pocket; other site
889738002985	Isochorismatase family; Region: Isochorismatase; pfam00857
889738002986	active site
889738002987	conserved cis-peptide bond; other site
889738002988	Aryl carrier domain [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3433
889738002989	histidine decarboxylase; Provisional; Region: PRK02769
889738002990	Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155
889738002991	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
889738002992	catalytic residue [active]
889738002993	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
889738002994	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
889738002995	Walker A/P-loop; other site
889738002996	ATP binding site [chemical binding]; other site
889738002997	Q-loop/lid; other site
889738002998	ABC transporter signature motif; other site
889738002999	Walker B; other site
889738003000	D-loop; other site
889738003001	H-loop/switch region; other site
889738003002	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
889738003003	putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608
889738003004	Walker A/P-loop; other site
889738003005	ATP binding site [chemical binding]; other site
889738003006	Q-loop/lid; other site
889738003007	ABC transporter signature motif; other site
889738003008	Walker B; other site
889738003009	D-loop; other site
889738003010	H-loop/switch region; other site
889738003011	Thioesterase domain; Region: Thioesterase; pfam00975
889738003012	4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648
889738003013	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
889738003014	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
889738003015	Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409
889738003016	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
889738003017	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
889738003018	Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717
889738003019	substrate binding site [chemical binding]; other site
889738003020	active site
889738003021	Protein of unknown function (DUF817); Region: DUF817; pfam05675
889738003022	Protein of unknown function (DUF3015); Region: DUF3015; pfam11220
889738003023	Domain of unknown function (DUF4105); Region: DUF4105; pfam13387
889738003024	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
889738003025	beta-lactamase/D-alanine carboxypeptidase; Provisional; Region: ampC; PRK11289
889738003026	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
889738003027	GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate.  The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria.  In...; Region: GTP_cyclohydro1; cd00642
889738003028	homodecamer interface [polypeptide binding]; other site
889738003029	GTP cyclohydrolase I; Provisional; Region: PLN03044
889738003030	active site
889738003031	putative catalytic site residues [active]
889738003032	zinc binding site [ion binding]; other site
889738003033	GTP-CH-I/GFRP interaction surface; other site
889738003034	xanthine dehydrogenase, small subunit; Region: xanthine_xdhA; TIGR02963
889738003035	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085
889738003036	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
889738003037	CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450
889738003038	xanthine dehydrogenase, molybdopterin binding subunit; Region: xanthine_xdhB; TIGR02965
889738003039	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
889738003040	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
889738003041	XdhC and CoxI family; Region: XdhC_CoxI; pfam02625
889738003042	xanthine dehydrogenase accessory protein XdhC; Region: xanthine_xdhC; TIGR02964
889738003043	XdhC Rossmann domain; Region: XdhC_C; pfam13478
889738003044	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2840
889738003045	Smr domain; Region: Smr; pfam01713
889738003046	Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331
889738003047	active site
889738003048	ribulose/triose binding site [chemical binding]; other site
889738003049	phosphate binding site [ion binding]; other site
889738003050	substrate (anthranilate) binding pocket [chemical binding]; other site
889738003051	product (indole) binding pocket [chemical binding]; other site
889738003052	anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188
889738003053	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
889738003054	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
889738003055	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
889738003056	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
889738003057	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
889738003058	Peptidase family M1; Region: Peptidase_M1; pfam01433
889738003059	Peptidase M1 Aminopeptidase N family incudes tricorn interacting factor F3, Endoplasmic reticulum aminopeptidase 1 (ERAP1), Aminopeptidase Q (APQ); Region: M1_APN_2; cd09601
889738003060	Zn binding site [ion binding]; other site
889738003061	Domain of unknown function (DUF3358); Region: DUF3358; pfam11838
889738003062	para-aminobenzoate synthase component II; Provisional; Region: PRK08857
889738003063	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
889738003064	glutamine binding [chemical binding]; other site
889738003065	catalytic triad [active]
889738003066	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
889738003067	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
889738003068	X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP; cd01085
889738003069	active site
889738003070	Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104
889738003071	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
889738003072	putative substrate translocation pore; other site
889738003073	POT family; Region: PTR2; cl17359
889738003074	glutamine synthetase; Provisional; Region: glnA; PRK09469
889738003075	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
889738003076	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
889738003077	Chorismate lyase; Region: Chor_lyase; cl01230
889738003078	4-hydroxybenzoate octaprenyltransferase; Reviewed; Region: ubiA; PRK12848
889738003079	UbiA prenyltransferase family; Region: UbiA; pfam01040
889738003080	Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506
889738003081	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
889738003082	Protein of unknown function (DUF2726); Region: DUF2726; pfam10881
889738003083	Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605
889738003084	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
889738003085	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
889738003086	NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371
889738003087	Uncharacterized conserved protein [Function unknown]; Region: COG0327
889738003088	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
889738003089	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
889738003090	protein binding site [polypeptide binding]; other site
889738003091	multifunctional tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase; Reviewed; Region: cca; PRK10885
889738003092	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
889738003093	active site
889738003094	NTP binding site [chemical binding]; other site
889738003095	metal binding triad [ion binding]; metal-binding site
889738003096	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
889738003097	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
889738003098	Zn2+ binding site [ion binding]; other site
889738003099	Mg2+ binding site [ion binding]; other site
889738003100	bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed; Region: PRK07232
889738003101	Malic enzyme, N-terminal domain; Region: malic; pfam00390
889738003102	NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311
889738003103	putative NAD(P) binding site [chemical binding]; other site
889738003104	Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280
889738003105	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
889738003106	PAS fold; Region: PAS_3; pfam08447
889738003107	heme pocket [chemical binding]; other site
889738003108	putative active site [active]
889738003109	PAS domain S-box; Region: sensory_box; TIGR00229
889738003110	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
889738003111	putative active site [active]
889738003112	heme pocket [chemical binding]; other site
889738003113	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
889738003114	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
889738003115	metal binding site [ion binding]; metal-binding site
889738003116	active site
889738003117	I-site; other site
889738003118	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
889738003119	16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713
889738003120	RNA methyltransferase, RsmE family; Region: TIGR00046
889738003121	Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537
889738003122	FAD binding site [chemical binding]; other site
889738003123	S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476
889738003124	S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401
889738003125	homotetramer interface [polypeptide binding]; other site
889738003126	ligand binding site [chemical binding]; other site
889738003127	catalytic site [active]
889738003128	NAD binding site [chemical binding]; other site
889738003129	Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296
889738003130	Carboxymuconolactone decarboxylase family; Region: CMD; cl00460
889738003131	acyl-CoA dehydrogenase; Reviewed; Region: fadE; PRK09463
889738003132	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
889738003133	active site
889738003134	Domain of unknown function (DUF1974); Region: DUF1974; pfam09317
889738003135	lipoyl synthase; Provisional; Region: PRK05481
889738003136	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
889738003137	FeS/SAM binding site; other site
889738003138	soluble pyridine nucleotide transhydrogenase; Provisional; Region: PRK05249
889738003139	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
889738003140	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
889738003141	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
889738003142	leucine-responsive transcriptional regulator; Provisional; Region: PRK11169
889738003143	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
889738003144	Major Facilitator Superfamily; Region: MFS_1; pfam07690
889738003145	putative substrate translocation pore; other site
889738003146	nitrite extrusion protein (nitrite facilitator); Region: 2A0108; TIGR00886
889738003147	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
889738003148	Outer membrane protein W [Cell envelope biogenesis, outer membrane]; Region: OmpW; COG3047
889738003149	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
889738003150	active site
889738003151	Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425
889738003152	rRNA interaction site [nucleotide binding]; other site
889738003153	S8 interaction site; other site
889738003154	putative laminin-1 binding site; other site
889738003155	elongation factor Ts; Provisional; Region: tsf; PRK09377
889738003156	UBA/TS-N domain; Region: UBA; pfam00627
889738003157	Elongation factor TS; Region: EF_TS; pfam00889
889738003158	Elongation factor TS; Region: EF_TS; pfam00889
889738003159	Protein of unknown function (DUF3465); Region: DUF3465; pfam11948
889738003160	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
889738003161	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
889738003162	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
889738003163	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
889738003164	Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296
889738003165	Branched-chain amino acid transport protein (AzlD); Region: AzlD; pfam05437
889738003166	Protein of unknown function (DUF962); Region: DUF962; cl01879
889738003167	Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797
889738003168	Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330
889738003169	Transglycosylase SLT domain; Region: SLT_2; pfam13406
889738003170	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
889738003171	N-acetyl-D-glucosamine binding site [chemical binding]; other site
889738003172	catalytic residue [active]
889738003173	rod shape-determining protein RodA; Region: rodA_shape; TIGR02210
889738003174	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2904
889738003175	7-cyano-7-deazaguanine reductase; Provisional; Region: queF; PRK11792
889738003176	Enzyme related to GTP cyclohydrolase I [General function prediction only]; Region: COG0780
889738003177	inner membrane transport permease; Provisional; Region: PRK15066
889738003178	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
889738003179	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
889738003180	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
889738003181	Walker A/P-loop; other site
889738003182	ATP binding site [chemical binding]; other site
889738003183	Q-loop/lid; other site
889738003184	ABC transporter signature motif; other site
889738003185	Walker B; other site
889738003186	D-loop; other site
889738003187	H-loop/switch region; other site
889738003188	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
889738003189	exodeoxyribonuclease X; Provisional; Region: PRK07983
889738003190	active site
889738003191	catalytic site [active]
889738003192	substrate binding site [chemical binding]; other site
889738003193	Protein of unknown function (DUF3820); Region: DUF3820; cl01411
889738003194	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
889738003195	Secretory lipase; Region: LIP; pfam03583
889738003196	Family of unknown function (DUF695); Region: DUF695; pfam05117
889738003197	Protein of unknown function (DUF1260); Region: DUF1260; pfam06877
889738003198	serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011
889738003199	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
889738003200	dimer interface [polypeptide binding]; other site
889738003201	active site
889738003202	glycine-pyridoxal phosphate binding site [chemical binding]; other site
889738003203	folate binding site [chemical binding]; other site
889738003204	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
889738003205	AcrB/AcrD/AcrF family; Region: ACR_tran; pfam00873
889738003206	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
889738003207	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
889738003208	HlyD family secretion protein; Region: HlyD_3; pfam13437
889738003209	Transcriptional regulator [Transcription]; Region: LysR; COG0583
889738003210	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
889738003211	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472
889738003212	putative effector binding pocket; other site
889738003213	putative dimerization interface [polypeptide binding]; other site
889738003214	lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096
889738003215	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
889738003216	substrate binding pocket [chemical binding]; other site
889738003217	membrane-bound complex binding site; other site
889738003218	hinge residues; other site
889738003219	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
889738003220	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
889738003221	dimer interface [polypeptide binding]; other site
889738003222	conserved gate region; other site
889738003223	putative PBP binding loops; other site
889738003224	ABC-ATPase subunit interface; other site
889738003225	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
889738003226	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
889738003227	dimer interface [polypeptide binding]; other site
889738003228	conserved gate region; other site
889738003229	putative PBP binding loops; other site
889738003230	ABC-ATPase subunit interface; other site
889738003231	ABC-type histidine transport system, ATPase component [Amino acid transport and metabolism]; Region: HisP; COG4598
889738003232	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
889738003233	Walker A/P-loop; other site
889738003234	ATP binding site [chemical binding]; other site
889738003235	Q-loop/lid; other site
889738003236	ABC transporter signature motif; other site
889738003237	Walker B; other site
889738003238	D-loop; other site
889738003239	H-loop/switch region; other site
889738003240	Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076
889738003241	archaeoflavoprotein, MJ0208 family; Region: flavo_MJ0208; TIGR02700
889738003242	putative protease; Provisional; Region: PRK15452
889738003243	Peptidase family U32; Region: Peptidase_U32; pfam01136
889738003244	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
889738003245	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
889738003246	DNA-binding site [nucleotide binding]; DNA binding site
889738003247	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
889738003248	pyridoxal 5'-phosphate binding site [chemical binding]; other site
889738003249	homodimer interface [polypeptide binding]; other site
889738003250	catalytic residue [active]
889738003251	Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384
889738003252	hydroxyproline-2-epimerase; Provisional; Region: PRK13971
889738003253	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
889738003254	Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195
889738003255	FAD binding pocket [chemical binding]; other site
889738003256	FAD binding motif [chemical binding]; other site
889738003257	phosphate binding motif [ion binding]; other site
889738003258	beta-alpha-beta structure motif; other site
889738003259	NAD binding pocket [chemical binding]; other site
889738003260	Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281
889738003261	homodimer interaction site [polypeptide binding]; other site
889738003262	cofactor binding site; other site
889738003263	Predicted membrane protein [Function unknown]; Region: COG3174
889738003264	Domain of unknown function (DUF4010); Region: DUF4010; pfam13194
889738003265	Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157
889738003266	Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804
889738003267	PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129
889738003268	Walker A motif; other site
889738003269	ATP binding site [chemical binding]; other site
889738003270	Walker B motif; other site
889738003271	Bacterial OB fold (BOF) protein; Region: BOF; cl01196
889738003272	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
889738003273	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
889738003274	active site
889738003275	phosphorylation site [posttranslational modification]
889738003276	intermolecular recognition site; other site
889738003277	dimerization interface [polypeptide binding]; other site
889738003278	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
889738003279	DNA binding site [nucleotide binding]
889738003280	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
889738003281	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
889738003282	dimer interface [polypeptide binding]; other site
889738003283	phosphorylation site [posttranslational modification]
889738003284	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
889738003285	ATP binding site [chemical binding]; other site
889738003286	Mg2+ binding site [ion binding]; other site
889738003287	G-X-G motif; other site
889738003288	Hemin uptake protein hemP; Region: hemP; cl10043
889738003289	hypothetical protein; Provisional; Region: PRK08999
889738003290	The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425
889738003291	active site
889738003292	8-oxo-dGMP binding site [chemical binding]; other site
889738003293	nudix motif; other site
889738003294	metal binding site [ion binding]; metal-binding site
889738003295	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
889738003296	thiamine phosphate binding site [chemical binding]; other site
889738003297	active site
889738003298	penicillin-binding protein 1B; Region: PBP_1b; TIGR02071
889738003299	Transglycosylase; Region: Transgly; pfam00912
889738003300	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
889738003301	inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK01231
889738003302	inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02231
889738003303	Protein of unknown function (DUF1315); Region: DUF1315; pfam07023
889738003304	hypothetical protein; Validated; Region: PRK09071
889738003305	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
889738003306	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
889738003307	C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663
889738003308	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
889738003309	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
889738003310	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
889738003311	active site
889738003312	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819
889738003313	Chorismate mutase type II; Region: CM_2; cl00693
889738003314	Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077
889738003315	Prephenate dehydratase; Region: PDT; pfam00800
889738003316	C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905
889738003317	putative L-Phe binding site [chemical binding]; other site
889738003318	bifunctional cyclohexadienyl dehydrogenase/ 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK14806
889738003319	prephenate dehydrogenase; Validated; Region: PRK08507
889738003320	EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556
889738003321	hinge; other site
889738003322	active site
889738003323	Xaa-His dipeptidase; Region: aa-his-dipept; TIGR01893
889738003324	M20 Peptidase D has specificity for beta-alanyl-L-histidine dipeptide; Region: M20_pepD; cd03890
889738003325	metal binding site [ion binding]; metal-binding site
889738003326	dimer interface [polypeptide binding]; other site
889738003327	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
889738003328	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2945
889738003329	hypothetical protein; Validated; Region: PRK02101
889738003330	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4339
889738003331	Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728
889738003332	ThiS interaction site; other site
889738003333	putative active site [active]
889738003334	tetramer interface [polypeptide binding]; other site
889738003335	ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565
889738003336	thiS-thiF/thiG interaction site; other site
889738003337	Uncharacterized small membrane protein [Function unknown]; Region: COG2363
889738003338	RNA polymerase factor sigma-32; Reviewed; Region: PRK06596
889738003339	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
889738003340	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
889738003341	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
889738003342	DNA binding residues [nucleotide binding]
889738003343	SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain.  SirA (also known as UvrY,  and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291
889738003344	CPxP  motif; other site
889738003345	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
889738003346	DNA-binding site [nucleotide binding]; DNA binding site
889738003347	RNA-binding motif; other site
889738003348	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
889738003349	DEAD-like helicases superfamily; Region: DEXDc; smart00487
889738003350	ATP binding site [chemical binding]; other site
889738003351	Mg++ binding site [ion binding]; other site
889738003352	motif III; other site
889738003353	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
889738003354	nucleotide binding region [chemical binding]; other site
889738003355	ATP-binding site [chemical binding]; other site
889738003356	Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135
889738003357	putative FMN binding site [chemical binding]; other site
889738003358	NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094
889738003359	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
889738003360	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
889738003361	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
889738003362	catalytic core [active]
889738003363	Type II secretion system (T2SS), protein L; Region: T2SL; pfam05134
889738003364	GspL periplasmic domain; Region: GspL_C; cl14909
889738003365	Type II secretion system (T2SS), protein M; Region: T2SM; cl01222
889738003366	dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286
889738003367	Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738
889738003368	quinone interaction residues [chemical binding]; other site
889738003369	active site
889738003370	catalytic residues [active]
889738003371	FMN binding site [chemical binding]; other site
889738003372	substrate binding site [chemical binding]; other site
889738003373	Colicin V production protein; Region: Colicin_V; pfam02674
889738003374	amidophosphoribosyltransferase; Provisional; Region: PRK09246
889738003375	Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of  glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715
889738003376	active site
889738003377	tetramer interface [polypeptide binding]; other site
889738003378	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
889738003379	active site
889738003380	Peptidase family M48; Region: Peptidase_M48; cl12018
889738003381	bifunctional glyoxylate/hydroxypyruvate reductase B; Provisional; Region: PRK15409
889738003382	D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301
889738003383	dimerization interface [polypeptide binding]; other site
889738003384	ligand binding site [chemical binding]; other site
889738003385	NADP binding site [chemical binding]; other site
889738003386	catalytic site [active]
889738003387	Putative Zn-dependent protease, contains TPR repeats [General function prediction only]; Region: COG4783
889738003388	Peptidase family M48; Region: Peptidase_M48; cl12018
889738003389	Yqey-like protein; Region: YqeY; pfam09424
889738003390	30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270
889738003391	UGMP family protein; Validated; Region: PRK09604
889738003392	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
889738003393	Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG2607
889738003394	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
889738003395	Walker A motif; other site
889738003396	ATP binding site [chemical binding]; other site
889738003397	Walker B motif; other site
889738003398	Domain of unknown function (DUF3336); Region: DUF3336; pfam11815
889738003399	Triacylglycerol lipase 3, 4, and 5 and Sugar-Dependent 1 lipase; Region: Pat_TGL3-4-5_SDP1; cd07206
889738003400	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752
889738003401	active site
889738003402	nucleophile elbow; other site
889738003403	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
889738003404	substrate binding site [chemical binding]; other site
889738003405	activation loop (A-loop); other site
889738003406	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
889738003407	Transcriptional regulator [Transcription]; Region: LysR; COG0583
889738003408	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
889738003409	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
889738003410	dimerization interface [polypeptide binding]; other site
889738003411	beta alanine--pyruvate transaminase; Provisional; Region: PRK09221
889738003412	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
889738003413	inhibitor-cofactor binding pocket; inhibition site
889738003414	pyridoxal 5'-phosphate binding site [chemical binding]; other site
889738003415	catalytic residue [active]
889738003416	Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085
889738003417	methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722
889738003418	tetrameric interface [polypeptide binding]; other site
889738003419	NAD binding site [chemical binding]; other site
889738003420	catalytic residues [active]
889738003421	gamma-aminobutyrate permease; Region: GABAperm; TIGR01773
889738003422	Uncharacterized protein conserved in bacteria (DUF2171); Region: DUF2171; pfam09939
889738003423	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
889738003424	active site
889738003425	GlcNAc-PI de-N-acetylase; Region: PIG-L; pfam02585
889738003426	Methyltransferase domain; Region: Methyltransf_31; pfam13847
889738003427	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
889738003428	S-adenosylmethionine binding site [chemical binding]; other site
889738003429	Bacterial OB fold (BOF) protein; Region: BOF; cl01196
889738003430	Sensors of blue-light using FAD; Region: BLUF; pfam04940
889738003431	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
889738003432	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
889738003433	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
889738003434	Helix-turn-helix domain; Region: HTH_18; pfam12833
889738003435	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
889738003436	Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167
889738003437	alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561
889738003438	Na+/glutamate symporter [Amino acid transport and metabolism]; Region: GltS; COG0786
889738003439	Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG2607
889738003440	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
889738003441	Walker A motif; other site
889738003442	ATP binding site [chemical binding]; other site
889738003443	Walker B motif; other site
889738003444	Transcriptional regulators [Transcription]; Region: FadR; COG2186
889738003445	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
889738003446	DNA-binding site [nucleotide binding]; DNA binding site
889738003447	FCD domain; Region: FCD; pfam07729
889738003448	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
889738003449	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
889738003450	Spore Coat Protein U domain; Region: SCPU; pfam05229
889738003451	Spore Coat Protein U domain; Region: SCPU; cl02253
889738003452	Spore Coat Protein U domain; Region: SCPU; pfam05229
889738003453	P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121
889738003454	Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345
889738003455	P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188
889738003456	Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577
889738003457	PapC C-terminal domain; Region: PapC_C; pfam13953
889738003458	Spore Coat Protein U domain; Region: SCPU; cl02253
889738003459	Spore Coat Protein U domain; Region: SCPU; pfam05229
889738003460	proline/glycine betaine transporter; Provisional; Region: PRK10642
889738003461	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
889738003462	putative substrate translocation pore; other site
889738003463	Osmosensory transporter coiled coil; Region: Osmo_CC; pfam08946
889738003464	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
889738003465	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
889738003466	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
889738003467	EamA-like transporter family; Region: EamA; pfam00892
889738003468	EamA-like transporter family; Region: EamA; pfam00892
889738003469	aspartate 4-decarboxylase; Region: asp_4_decarbox; TIGR03801
889738003470	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
889738003471	pyridoxal 5'-phosphate binding site [chemical binding]; other site
889738003472	homodimer interface [polypeptide binding]; other site
889738003473	catalytic residue [active]
889738003474	aspartate-alanine antiporter; Region: Asp_Ala_antiprt; TIGR03802
889738003475	Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826
889738003476	TrkA-C domain; Region: TrkA_C; pfam02080
889738003477	TrkA-C domain; Region: TrkA_C; pfam02080
889738003478	Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826
889738003479	Paraquat-inducible protein A; Region: PqiA; pfam04403
889738003480	Paraquat-inducible protein A; Region: PqiA; pfam04403
889738003481	mce related protein; Region: MCE; pfam02470
889738003482	mce related protein; Region: MCE; pfam02470
889738003483	mce related protein; Region: MCE; pfam02470
889738003484	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3009
889738003485	Protein of unknown function (DUF330); Region: DUF330; pfam03886
889738003486	Aspartate racemase [Cell envelope biogenesis, outer membrane]; Region: RacX; COG1794
889738003487	aspartate racemase; Region: asp_race; TIGR00035
889738003488	aromatic amino acid exporter; Provisional; Region: PRK11689
889738003489	EamA-like transporter family; Region: EamA; pfam00892
889738003490	Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133
889738003491	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
889738003492	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
889738003493	Coenzyme A binding pocket [chemical binding]; other site
889738003494	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316
889738003495	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
889738003496	Integrase core domain; Region: rve; pfam00665
889738003497	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
889738003498	Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523
889738003499	Siderophore biosynthesis protein domain; Region: AlcB; smart01006
889738003500	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
889738003501	Coenzyme A binding pocket [chemical binding]; other site
889738003502	Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110
889738003503	Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349
889738003504	trimer interface [polypeptide binding]; other site
889738003505	active site
889738003506	substrate binding site [chemical binding]; other site
889738003507	CoA binding site [chemical binding]; other site
889738003508	aminoglycoside resistance protein; Provisional; Region: PRK13746
889738003509	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
889738003510	active site
889738003511	NTP binding site [chemical binding]; other site
889738003512	metal binding triad [ion binding]; metal-binding site
889738003513	antibiotic binding site [chemical binding]; other site
889738003514	Domain of unknown function (DUF4111); Region: DUF4111; pfam13427
889738003515	Small Multidrug Resistance protein; Region: Multi_Drug_Res; pfam00893
889738003516	DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
889738003517	dihydropteroate synthase; Region: DHPS; TIGR01496
889738003518	substrate binding pocket [chemical binding]; other site
889738003519	dimer interface [polypeptide binding]; other site
889738003520	inhibitor binding site; inhibition site
889738003521	Transposase zinc-binding domain; Region: Zn_Tnp_IS91; pfam14319
889738003522	Ribosomal protein S27; Region: Ribosomal_S27e; cl00897
889738003523	Putative transposase; Region: Y2_Tnp; pfam04986
889738003524	Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737
889738003525	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
889738003526	Ribosomal RNA methyltransferase (FmrO); Region: FmrO; pfam07091
889738003527	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
889738003528	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
889738003529	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
889738003530	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
889738003531	ABC transporter; Region: ABC_tran_2; pfam12848
889738003532	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
889738003533	Macrolide 2'-Phosphotransferase (MPH2'). MPH2' is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase; Region: MPH2' cd05152
889738003534	putative active site [active]
889738003535	putative substrate binding site [chemical binding]; other site
889738003536	Phosphotransferase enzyme family; Region: APH; pfam01636
889738003537	ATP binding site [chemical binding]; other site
889738003538	Modifier of rudimentary (Mod(r)) protein; Region: Mod_r; pfam07200
889738003539	Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007
889738003540	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
889738003541	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005
889738003542	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
889738003543	IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817
889738003544	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
889738003545	IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717
889738003546	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2739; cl17893
889738003547	Initiator Replication protein; Region: Rep_3; pfam01051
889738003548	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316
889738003549	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
889738003550	Integrase core domain; Region: rve; pfam00665
889738003551	Major Facilitator Superfamily; Region: MFS_1; pfam07690
889738003552	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl17904
889738003553	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
889738003554	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
889738003555	C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663
889738003556	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
889738003557	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
889738003558	hydroxyacylglutathione hydrolase; Region: GSH_gloB; TIGR03413
889738003559	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
889738003560	dimer interface [polypeptide binding]; other site
889738003561	conserved gate region; other site
889738003562	ABC-ATPase subunit interface; other site
889738003563	DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153
889738003564	ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258
889738003565	Walker A/P-loop; other site
889738003566	ATP binding site [chemical binding]; other site
889738003567	Q-loop/lid; other site
889738003568	ABC transporter signature motif; other site
889738003569	Walker B; other site
889738003570	D-loop; other site
889738003571	H-loop/switch region; other site
889738003572	NIL domain; Region: NIL; pfam09383
889738003573	ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464
889738003574	NLPA lipoprotein; Region: Lipoprotein_9; pfam03180
889738003575	phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885
889738003576	Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844
889738003577	Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071
889738003578	Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843
889738003579	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881
889738003580	Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal  ATIC formylase domain that formylates...; Region: IMPCH; cd01421
889738003581	purine monophosphate binding site [chemical binding]; other site
889738003582	dimer interface [polypeptide binding]; other site
889738003583	putative catalytic residues [active]
889738003584	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798
889738003585	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362
889738003586	Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420
889738003587	MJ0042 family finger-like domain; Region: MJ0042_CXXC; TIGR02098
889738003588	Protein of unknown function (DUF3426); Region: DUF3426; pfam11906
889738003589	Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325
889738003590	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
889738003591	S-adenosylmethionine binding site [chemical binding]; other site
889738003592	tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192
889738003593	NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206
889738003594	GidA associated domain 3; Region: GIDA_assoc_3; pfam13932
889738003595	Predicted transcriptional regulator [Transcription]; Region: COG2378
889738003596	WYL domain; Region: WYL; pfam13280
889738003597	Uncharacterized conserved protein [Function unknown]; Region: COG2308
889738003598	A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168
889738003599	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
889738003600	Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379
889738003601	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
889738003602	Predicted proteasome-type protease [Posttranslational modification, protein turnover, chaperones]; Region: COG3484
889738003603	Bacterial proteasome, beta subunit. The 20S proteasome, multisubunit proteolytic complex, is the central enzyme of nonlysosomal protein degradation in both the cytosol and nucleus. It is composed of 28 subunits arranged as four homoheptameric rings that...; Region: proteasome_beta_bacterial; cd03765
889738003604	alanine racemase; Reviewed; Region: alr; PRK00053
889738003605	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827
889738003606	active site
889738003607	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
889738003608	substrate binding site [chemical binding]; other site
889738003609	catalytic residues [active]
889738003610	dimer interface [polypeptide binding]; other site
889738003611	replicative DNA helicase; Region: DnaB; TIGR00665
889738003612	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
889738003613	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
889738003614	Walker A motif; other site
889738003615	ATP binding site [chemical binding]; other site
889738003616	Walker B motif; other site
889738003617	DNA binding loops [nucleotide binding]
889738003618	50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137
889738003619	Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281
889738003620	Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948
889738003621	30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391
889738003622	30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453
889738003623	protoheme IX farnesyltransferase; Provisional; Region: PRK04375
889738003624	UbiA prenyltransferase family; Region: UbiA; pfam01040
889738003625	cytochrome o ubiquinol oxidase subunit IV; Provisional; Region: PRK10582
889738003626	Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane.  It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863
889738003627	Subunit I/III interface [polypeptide binding]; other site
889738003628	Subunit III/IV interface [polypeptide binding]; other site
889738003629	Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843
889738003630	Ubiquinol oxidase subunit I.  Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane.  It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662
889738003631	D-pathway; other site
889738003632	Putative ubiquinol binding site [chemical binding]; other site
889738003633	Low-spin heme (heme b) binding site [chemical binding]; other site
889738003634	Putative water exit pathway; other site
889738003635	Binuclear center (heme o3/CuB) [ion binding]; other site
889738003636	K-pathway; other site
889738003637	Putative proton exit pathway; other site
889738003638	cytochrome o ubiquinol oxidase subunit II; Region: CyoA; TIGR01433
889738003639	COX Aromatic Rich Motif; Region: COX_ARM; pfam06481
889738003640	Domain of unknown function (DUF4339); Region: DUF4339; pfam14237
889738003641	RDD family; Region: RDD; pfam06271
889738003642	phosphoenolpyruvate synthase; Validated; Region: PRK06464
889738003643	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
889738003644	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
889738003645	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
889738003646	PEP synthetase regulatory protein; Provisional; Region: PRK05339
889738003647	poly-beta-1,6 N-acetyl-D-glucosamine export porin PgaA; Region: PGA_TPR_OMP; TIGR03939
889738003648	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
889738003649	binding surface
889738003650	TPR motif; other site
889738003651	poly-beta-1,6-N-acetyl-D-glucosamine N-deacetylase PgaB; Region: deacetyl_PgaB; TIGR03938
889738003652	N-terminal putative catalytic polysaccharide deacetylase domain of bacterial poly-beta-1,6-N-acetyl-D-glucosamine N-deacetylase PgaB, and similar proteins; Region: CE4_PgaB_5s; cd10964
889738003653	putative active site [active]
889738003654	putative metal binding site [ion binding]; other site
889738003655	N-glycosyltransferase; Provisional; Region: PRK11204
889738003656	CESA_like is  the cellulose synthase superfamily; Region: CESA_like; cd06423
889738003657	DXD motif; other site
889738003658	PgaD-like protein; Region: PgaD; pfam13994
889738003659	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
889738003660	luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558
889738003661	probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858
889738003662	Transcriptional regulator [Transcription]; Region: LysR; COG0583
889738003663	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
889738003664	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
889738003665	putative effector binding pocket; other site
889738003666	dimerization interface [polypeptide binding]; other site
889738003667	Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693
889738003668	Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141
889738003669	potential catalytic triad [active]
889738003670	conserved cys residue [active]
889738003671	peptide chain release factor 1; Validated; Region: prfA; PRK00591
889738003672	This domain is found in peptide chain release factors; Region: PCRF; smart00937
889738003673	RF-1 domain; Region: RF-1; pfam00472
889738003674	N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328
889738003675	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
889738003676	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
889738003677	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
889738003678	ABC-ATPase subunit interface; other site
889738003679	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
889738003680	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
889738003681	substrate binding pocket [chemical binding]; other site
889738003682	ABC transporter periplasmic binding protein, urea carboxylase region; Region: ABC_peri_uca; TIGR03427
889738003683	membrane-bound complex binding site; other site
889738003684	Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625
889738003685	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
889738003686	SurA N-terminal domain; Region: SurA_N; pfam09312
889738003687	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
889738003688	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08217
889738003689	17hydroxysteroid dehydrogenase type 10 (HSD10)-like, classical (c) SDRs; Region: HSD10-like_SDR_c; cd05371
889738003690	NAD binding site [chemical binding]; other site
889738003691	homodimer interface [polypeptide binding]; other site
889738003692	homotetramer interface [polypeptide binding]; other site
889738003693	active site
889738003694	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
889738003695	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
889738003696	active site
889738003697	Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365
889738003698	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
889738003699	acyl-activating enzyme (AAE) consensus motif; other site
889738003700	AMP binding site [chemical binding]; other site
889738003701	active site
889738003702	CoA binding site [chemical binding]; other site
889738003703	Flavin reductase like domain; Region: Flavin_Reduct; smart00903
889738003704	molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690
889738003705	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
889738003706	ATP binding site [chemical binding]; other site
889738003707	substrate interface [chemical binding]; other site
889738003708	Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661
889738003709	ABC1 family; Region: ABC1; cl17513
889738003710	Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534
889738003711	homooctamer interface [polypeptide binding]; other site
889738003712	active site
889738003713	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cl00233
889738003714	catalytic center binding site [active]
889738003715	ATP binding site [chemical binding]; other site
889738003716	potassium-transporting ATPase subunit A; Provisional; Region: PRK05482
889738003717	potassium-transporting ATPase subunit B; Provisional; Region: PRK01122
889738003718	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
889738003719	Soluble P-type ATPase [General function prediction only]; Region: COG4087
889738003720	potassium-transporting ATPase subunit C; Reviewed; Region: PRK00315
889738003721	Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205
889738003722	Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702
889738003723	USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987
889738003724	Ligand Binding Site [chemical binding]; other site
889738003725	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
889738003726	dimer interface [polypeptide binding]; other site
889738003727	phosphorylation site [posttranslational modification]
889738003728	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
889738003729	ATP binding site [chemical binding]; other site
889738003730	Mg2+ binding site [ion binding]; other site
889738003731	G-X-G motif; other site
889738003732	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
889738003733	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
889738003734	active site
889738003735	phosphorylation site [posttranslational modification]
889738003736	intermolecular recognition site; other site
889738003737	dimerization interface [polypeptide binding]; other site
889738003738	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
889738003739	DNA binding site [nucleotide binding]
889738003740	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
889738003741	Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174
889738003742	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
889738003743	Protein of unknown function (DUF2799); Region: DUF2799; pfam10973
889738003744	Demethoxyubiquinone hydroxylase, ferritin-like diiron-binding domain; Region: DMQH; cd01042
889738003745	diiron binding motif [ion binding]; other site
889738003746	lysophospholipid transporter LplT; Provisional; Region: PRK11195
889738003747	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
889738003748	putative substrate translocation pore; other site
889738003749	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
889738003750	Membrane-fusion protein [Cell envelope biogenesis, outer membrane]; Region: AcrA; COG0845
889738003751	Surface antigen; Region: Bac_surface_Ag; pfam01103
889738003752	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911
889738003753	Family of unknown function (DUF490); Region: DUF490; pfam04357
889738003754	bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238
889738003755	Aconitase B swivel domain. Aconitate hydratase B is involved in energy metabolism as part of the TCA cycle. It catalyses the formation of cis-aconitate from citrate. This is the aconitase swivel domain, which undergoes swivelling conformational change in...; Region: AcnB_Swivel; cd01576
889738003756	substrate binding site [chemical binding]; other site
889738003757	Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle; Region: AcnB; cd01581
889738003758	substrate binding site [chemical binding]; other site
889738003759	ligand binding site [chemical binding]; other site
889738003760	Ion transport protein; Region: Ion_trans; pfam00520
889738003761	Ion channel; Region: Ion_trans_2; pfam07885
889738003762	CCC1-related family of proteins; Region: CCC1_like; cl00278
889738003763	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
889738003764	Major Facilitator Superfamily; Region: MFS_1; pfam07690
889738003765	putative substrate translocation pore; other site
889738003766	conjugal transfer nickase/helicase TraI; Provisional; Region: PRK14712
889738003767	Domain of unknown function (DUF4198); Region: DUF4198; pfam10670
889738003768	Transcriptional regulator [Transcription]; Region: LysR; COG0583
889738003769	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
889738003770	The C-terminal substrate binding domain of LysR-type transcriptional regulator metR, which regulates the expression of methionine biosynthetic genes, contains type 2 periplasmic binding fold; Region: PBP2_MetR; cd08441
889738003771	putative dimerization interface [polypeptide binding]; other site
889738003772	Protein of unknown function (DUF441); Region: DUF441; pfam04284
889738003773	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
889738003774	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
889738003775	RNA binding surface [nucleotide binding]; other site
889738003776	Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553
889738003777	active site
889738003778	uracil binding [chemical binding]; other site
889738003779	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
889738003780	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
889738003781	Coenzyme A binding pocket [chemical binding]; other site
889738003782	RelB antitoxin; Region: RelB; cl01171
889738003783	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
889738003784	Pseudouridine synthase, a subgroup of the RluA family; Region: PSRA_1; cd02558
889738003785	probable active site [active]
889738003786	Uncharacterized P-loop hydrolase UPF0079; Region: UPF0079; cl00520
889738003787	DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095
889738003788	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
889738003789	ATP binding site [chemical binding]; other site
889738003790	Mg2+ binding site [ion binding]; other site
889738003791	G-X-G motif; other site
889738003792	MutL_Trans_MutL: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to Escherichia coli MutL.  EcMutL belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family.  This transducer domain is homologous to the second...; Region: MutL_Trans_MutL; cd03482
889738003793	ATP binding site [chemical binding]; other site
889738003794	MutL C terminal dimerisation domain; Region: MutL_C; pfam08676
889738003795	tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324
889738003796	tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091
889738003797	bacterial Hfq-like; Region: Hfq; cd01716
889738003798	hexamer interface [polypeptide binding]; other site
889738003799	Sm1 motif; other site
889738003800	RNA binding site [nucleotide binding]; other site
889738003801	Sm2 motif; other site
889738003802	EamA-like transporter family; Region: EamA; pfam00892
889738003803	phosphonate utilization associated putative membrane protein; Region: phn_DUF6; TIGR03340
889738003804	NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149
889738003805	dimer interface [polypeptide binding]; other site
889738003806	FMN binding site [chemical binding]; other site
889738003807	cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920
889738003808	substrate binding site [chemical binding]; other site
889738003809	glutaminyl-tRNA synthetase; Provisional; Region: PRK05347
889738003810	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
889738003811	active site
889738003812	HIGH motif; other site
889738003813	nucleotide binding site [chemical binding]; other site
889738003814	catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807
889738003815	KMSKS motif; other site
889738003816	tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950
889738003817	GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518
889738003818	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741
889738003819	catalytic triad [active]
889738003820	ethanolamine ammonia-lyase small subunit; Provisional; Region: PRK05465
889738003821	ethanolamine ammonia lyase large subunit; Provisional; Region: PRK15067
889738003822	Ethanolamine ammonia lyase large subunit (EutB); Region: EutB; pfam06751
889738003823	ethanolamine permease; Region: 2A0305; TIGR00908
889738003824	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
889738003825	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
889738003826	NAD(P) binding site [chemical binding]; other site
889738003827	catalytic residues [active]
889738003828	Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862
889738003829	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
889738003830	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
889738003831	Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176
889738003832	Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454
889738003833	dimer interface [polypeptide binding]; other site
889738003834	active site
889738003835	metal binding site [ion binding]; metal-binding site
889738003836	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
889738003837	PIF1-like helicase; Region: PIF1; pfam05970
889738003838	Walker A motif; other site
889738003839	ATP binding site [chemical binding]; other site
889738003840	Walker B motif; other site
889738003841	5-carboxymethyl-2-hydroxymuconate isomerase (CHMI) is a trimeric enzyme catalyzing the isomerization of the unsaturated ketone 5-(carboxymethyl)-2-hydroxymuconate to 5-(carboxymethyl)-2-oxo-3-hexene-1,6-dionate. This is one step in the...; Region: CHMI; cd00580
889738003842	putative substrate binding pocket [chemical binding]; other site
889738003843	trimer interface [polypeptide binding]; other site
889738003844	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
889738003845	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
889738003846	DNA gyrase inhibitor [DNA replication, recombination, and repair]; Region: COG3449
889738003847	4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170
889738003848	substrate binding site [chemical binding]; other site
889738003849	multimerization interface [polypeptide binding]; other site
889738003850	ATP binding site [chemical binding]; other site
889738003851	aminopeptidase N; Provisional; Region: pepN; PRK14015
889738003852	Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_1; cd09600
889738003853	active site
889738003854	Zn binding site [ion binding]; other site
889738003855	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
889738003856	Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of  glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570
889738003857	C-terminal domain interface [polypeptide binding]; other site
889738003858	GSH binding site (G-site) [chemical binding]; other site
889738003859	dimer interface [polypeptide binding]; other site
889738003860	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299
889738003861	N-terminal domain interface [polypeptide binding]; other site
889738003862	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
889738003863	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
889738003864	NAD(P) binding site [chemical binding]; other site
889738003865	active site
889738003866	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
889738003867	active site
889738003868	chorismate mutase; Provisional; Region: PRK08055
889738003869	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
889738003870	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
889738003871	putative DNA binding site [nucleotide binding]; other site
889738003872	putative Zn2+ binding site [ion binding]; other site
889738003873	AsnC family; Region: AsnC_trans_reg; pfam01037
889738003874	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
889738003875	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
889738003876	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
889738003877	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
889738003878	N-terminal plug; other site
889738003879	ligand-binding site [chemical binding]; other site
889738003880	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
889738003881	Mechanosensitive ion channel; Region: MS_channel; pfam00924
889738003882	synaptic vesicle protein SV2; Region: synapt_SV2; TIGR01299
889738003883	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
889738003884	Coenzyme A binding pocket [chemical binding]; other site
889738003885	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
889738003886	Outer membrane receptor for ferric coprogen and ferric-rhodotorulic acid [Inorganic ion transport and metabolism]; Region: FhuE; COG4773
889738003887	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
889738003888	N-terminal plug; other site
889738003889	ligand-binding site [chemical binding]; other site
889738003890	Outer membrane protein W [Cell envelope biogenesis, outer membrane]; Region: OmpW; COG3047
889738003891	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
889738003892	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
889738003893	Walker A/P-loop; other site
889738003894	ATP binding site [chemical binding]; other site
889738003895	Q-loop/lid; other site
889738003896	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
889738003897	ABC transporter signature motif; other site
889738003898	Walker B; other site
889738003899	D-loop; other site
889738003900	ABC transporter; Region: ABC_tran_2; pfam12848
889738003901	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
889738003902	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
889738003903	Ligand Binding Site [chemical binding]; other site
889738003904	dipeptidase, putative; Region: dipeptidaselike; TIGR01887
889738003905	RDD family; Region: RDD; pfam06271
889738003906	magnesium-transporting ATPase MgtA; Provisional; Region: PRK10517
889738003907	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690
889738003908	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
889738003909	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
889738003910	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
889738003911	Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285
889738003912	MgtC family; Region: MgtC; pfam02308
889738003913	Benzoate membrane transport protein; Region: BenE; pfam03594
889738003914	benzoate transporter; Region: benE; TIGR00843
889738003915	leucine-responsive transcriptional regulator; Provisional; Region: PRK11169
889738003916	Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412
889738003917	AsnC family; Region: AsnC_trans_reg; pfam01037
889738003918	leucine export protein LeuE; Provisional; Region: PRK10958
889738003919	transaldolase-like protein; Provisional; Region: PTZ00411
889738003920	Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957
889738003921	active site
889738003922	dimer interface [polypeptide binding]; other site
889738003923	catalytic residue [active]
889738003924	Transcriptional regulator [Transcription]; Region: LysR; COG0583
889738003925	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
889738003926	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
889738003927	dimerization interface [polypeptide binding]; other site
889738003928	Bacterial Transmembrane Pair family; Region: BTP; pfam05232
889738003929	Bacterial Transmembrane Pair family; Region: BTP; pfam05232
889738003930	acetyl-CoA acetyltransferase; Provisional; Region: PRK09268
889738003931	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
889738003932	dimer interface [polypeptide binding]; other site
889738003933	active site
889738003934	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08261
889738003935	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
889738003936	NAD(P) binding site [chemical binding]; other site
889738003937	active site
889738003938	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
889738003939	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
889738003940	active site 2 [active]
889738003941	active site 1 [active]
889738003942	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
889738003943	Beta-lactamase; Region: Beta-lactamase; pfam00144
889738003944	TetR family transcriptional regulator; Provisional; Region: PRK14996
889738003945	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
889738003946	methyl viologen resistance protein SmvA; Provisional; Region: PRK14995
889738003947	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
889738003948	putative substrate translocation pore; other site
889738003949	DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14960
889738003950	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
889738003951	Walker A motif; other site
889738003952	ATP binding site [chemical binding]; other site
889738003953	Walker B motif; other site
889738003954	arginine finger; other site
889738003955	DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169
889738003956	phospholipase C, phosphocholine-specific, Pseudomonas-type; Region: PC_PLC; TIGR03396
889738003957	Phosphoesterase family; Region: Phosphoesterase; pfam04185
889738003958	Domain of unknown function (DUF756); Region: DUF756; pfam05506
889738003959	Domain of unknown function (DUF756); Region: DUF756; pfam05506
889738003960	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
889738003961	active site
889738003962	Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454
889738003963	5-hydroxyvalerate dehydrogenase (HVD) catalyzes the oxidation of 5-hydroxyvalerate to 5-oxovalerate with NAD+ as cofactor; Region: HVD; cd08193
889738003964	putative active site [active]
889738003965	metal binding site [ion binding]; metal-binding site
889738003966	Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282
889738003967	Low molecular weight phosphatase family; Region: LMWPc; cd00115
889738003968	Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451
889738003969	active site
889738003970	UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK00046
889738003971	FAD binding domain; Region: FAD_binding_4; pfam01565
889738003972	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873
889738003973	Uncharacterized conserved protein [Function unknown]; Region: COG1434
889738003974	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
889738003975	putative active site [active]
889738003976	Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267
889738003977	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
889738003978	Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069
889738003979	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
889738003980	active site
889738003981	FMN binding site [chemical binding]; other site
889738003982	substrate binding site [chemical binding]; other site
889738003983	3Fe-4S cluster binding site [ion binding]; other site
889738003984	Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182
889738003985	PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703
889738003986	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
889738003987	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
889738003988	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
889738003989	active site
889738003990	Int/Topo IB signature motif; other site
889738003991	DNA binding site [nucleotide binding]
889738003992	AAA domain; Region: AAA_24; pfam13479
889738003993	phage nucleotide-binding protein; Region: phage_P_loop; TIGR01618
889738003994	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
889738003995	non-specific DNA binding site [nucleotide binding]; other site
889738003996	salt bridge; other site
889738003997	SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974
889738003998	sequence-specific DNA binding site [nucleotide binding]; other site
889738003999	The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cd06462
889738004000	Catalytic site [active]
889738004001	Uncharacterized protein conserved in bacteria, prophage-related [Function unknown]; Region: COG4197
889738004002	Protein of unknown function (DUF1376); Region: DUF1376; pfam07120
889738004003	Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277
889738004004	putative active site [active]
889738004005	Uncharacterized conserved protein (DUF2280); Region: DUF2280; cl02353
889738004006	large terminase protein; Provisional; Region: 17; PHA02533
889738004007	Phage terminase large subunit; Region: Terminase_3; cl12054
889738004008	phage-related protein, HI1409 family; Region: phge_rel_HI1409; TIGR01555
889738004009	Protein of unknown function (DUF1073); Region: DUF1073; pfam06381
889738004010	Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072
889738004011	potential frameshift: common BLAST hit: gi|384143859|ref|YP_005526569.1| putative bacteriophage protein
889738004012	Uncharacterized protein conserved in bacteria (DUF2213); Region: DUF2213; pfam09979
889738004013	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4834
889738004014	Uncharacterized protein conserved in bacteria (DUF2184); Region: DUF2184; pfam09950
889738004015	Protein of unknown function (DUF4054); Region: DUF4054; pfam13262
889738004016	Protein of unknown function (DUF3383); Region: DUF3383; pfam11863
889738004017	Protein of unknown function (DUF3277); Region: DUF3277; pfam11681
889738004018	phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760
889738004019	Protein of unknown function (DUF1311); Region: DUF1311; pfam07007
889738004020	Baseplate J-like protein; Region: Baseplate_J; cl01294
889738004021	Protein of unknown function (DUF2612); Region: DUF2612; pfam11041
889738004022	Glycosyl hydrolase 108; Region: Glyco_hydro_108; pfam05838
889738004023	Predicted Peptidoglycan domain; Region: PG_binding_3; pfam09374
889738004024	Domain of unknown function (DUF4113); Region: DUF4113; pfam13438
889738004025	putative transposase OrfB; Reviewed; Region: PHA02517
889738004026	HTH-like domain; Region: HTH_21; pfam13276
889738004027	Integrase core domain; Region: rve; pfam00665
889738004028	Integrase core domain; Region: rve_3; pfam13683
889738004029	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
889738004030	Transposase; Region: HTH_Tnp_1; pfam01527
889738004031	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
889738004032	putative 3-phenylpropionic acid transporter; Provisional; Region: PRK11128
889738004033	putative substrate translocation pore; other site
889738004034	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
889738004035	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
889738004036	ATP-grasp domain; Region: ATP-grasp_4; cl17255
889738004037	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
889738004038	acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302
889738004039	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
889738004040	carboxyltransferase (CT) interaction site; other site
889738004041	biotinylation site [posttranslational modification]; other site
889738004042	Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466
889738004043	Dehydroquinase class II; Region: DHquinase_II; pfam01220
889738004044	trimer interface [polypeptide binding]; other site
889738004045	active site
889738004046	dimer interface [polypeptide binding]; other site
889738004047	DNA polymerase V subunit UmuC; Reviewed; Region: umuC; PRK03609
889738004048	umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700
889738004049	active site
889738004050	DNA binding site [nucleotide binding]
889738004051	Domain of unknown function (DUF4113); Region: DUF4113; pfam13438
889738004052	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
889738004053	NMT1-like family; Region: NMT1_2; pfam13379
889738004054	Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707
889738004055	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
889738004056	active site
889738004057	phosphorylation site [posttranslational modification]
889738004058	intermolecular recognition site; other site
889738004059	dimerization interface [polypeptide binding]; other site
889738004060	ANTAR domain; Region: ANTAR; pfam03861
889738004061	nitrite reductase subunit NirD; Provisional; Region: PRK14989
889738004062	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
889738004063	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
889738004064	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
889738004065	Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529
889738004066	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992
889738004067	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
889738004068	Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243
889738004069	Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754
889738004070	[4Fe-4S] binding site [ion binding]; other site
889738004071	molybdopterin cofactor binding site; other site
889738004072	Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791
889738004073	molybdopterin cofactor binding site; other site
889738004074	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
889738004075	molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317
889738004076	MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503
889738004077	GTP binding site; other site
889738004078	Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243
889738004079	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
889738004080	molybdopterin cofactor binding site; other site
889738004081	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
889738004082	The MopB_CT_1 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. This CD is of the...; Region: MopB_CT_1; cd02782
889738004083	putative molybdopterin cofactor binding site; other site
889738004084	molybdenum cofactor biosynthesis protein A, bacterial; Region: moaA; TIGR02666
889738004085	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
889738004086	FeS/SAM binding site; other site
889738004087	Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463
889738004088	MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756
889738004089	MoaE homodimer interface [polypeptide binding]; other site
889738004090	MoaD interaction [polypeptide binding]; other site
889738004091	active site residues [active]
889738004092	bifunctional molybdenum cofactor biosynthesis protein MoaC/MogA; Provisional; Region: moaC; PRK03604
889738004093	MoaC family. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine derivative to the precursor...; Region: MoaC; cl00242
889738004094	trimer interface [polypeptide binding]; other site
889738004095	dimer interface [polypeptide binding]; other site
889738004096	putative active site [active]
889738004097	MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886
889738004098	MPT binding site; other site
889738004099	trimer interface [polypeptide binding]; other site
889738004100	Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303
889738004101	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
889738004102	dimer interface [polypeptide binding]; other site
889738004103	putative functional site; other site
889738004104	putative MPT binding site; other site
889738004105	Predicted transcriptional regulators [Transcription]; Region: COG1733
889738004106	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
889738004107	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
889738004108	DNA-binding site [nucleotide binding]; DNA binding site
889738004109	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
889738004110	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
889738004111	pyridoxal 5'-phosphate binding site [chemical binding]; other site
889738004112	homodimer interface [polypeptide binding]; other site
889738004113	catalytic residue [active]
889738004114	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
889738004115	EamA-like transporter family; Region: EamA; pfam00892
889738004116	EamA-like transporter family; Region: EamA; pfam00892
889738004117	Dissimilatory sulfite reductase (desulfoviridin), gamma subunit [Inorganic ion transport and metabolism]; Region: DsrC; COG2920
889738004118	DsrC like protein; Region: DsrC; pfam04358
889738004119	sulfur relay protein TusD/DsrE; Region: sulf_tusD_dsrE; TIGR03012
889738004120	UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087
889738004121	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
889738004122	NAD(P) binding site [chemical binding]; other site
889738004123	active site
889738004124	fumarate hydratase; Reviewed; Region: fumC; PRK00485
889738004125	Class II fumarases; Region: Fumarase_classII; cd01362
889738004126	active site
889738004127	tetramer interface [polypeptide binding]; other site
889738004128	D-amino acid dehydrogenase small subunit; Provisional; Region: PRK12409
889738004129	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
889738004130	hydroxyglutarate oxidase; Provisional; Region: PRK11728
889738004131	MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554
889738004132	homotrimer interaction site [polypeptide binding]; other site
889738004133	zinc binding site [ion binding]; other site
889738004134	CDP-binding sites; other site
889738004135	Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053
889738004136	catalytic residues [active]
889738004137	active site
889738004138	ornithine carbamoyltransferase; Provisional; Region: PRK00779
889738004139	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
889738004140	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
889738004141	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
889738004142	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
889738004143	nitrogen regulation protein NR(I); Region: ntrC; TIGR01818
889738004144	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
889738004145	active site
889738004146	phosphorylation site [posttranslational modification]
889738004147	intermolecular recognition site; other site
889738004148	dimerization interface [polypeptide binding]; other site
889738004149	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
889738004150	Walker A motif; other site
889738004151	ATP binding site [chemical binding]; other site
889738004152	Walker B motif; other site
889738004153	arginine finger; other site
889738004154	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
889738004155	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
889738004156	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
889738004157	putative active site [active]
889738004158	heme pocket [chemical binding]; other site
889738004159	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
889738004160	dimer interface [polypeptide binding]; other site
889738004161	phosphorylation site [posttranslational modification]
889738004162	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
889738004163	ATP binding site [chemical binding]; other site
889738004164	Mg2+ binding site [ion binding]; other site
889738004165	G-X-G motif; other site
889738004166	ribosomal protein S12 methylthiotransferase; Provisional; Region: rimO; PRK14862
889738004167	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
889738004168	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
889738004169	FeS/SAM binding site; other site
889738004170	UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254
889738004171	putative nucleotide binding site [chemical binding]; other site
889738004172	uridine monophosphate binding site [chemical binding]; other site
889738004173	homohexameric interface [polypeptide binding]; other site
889738004174	ribosome recycling factor; Reviewed; Region: frr; PRK00083
889738004175	Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation.  Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520
889738004176	hinge region; other site
889738004177	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230
889738004178	Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255
889738004179	catalytic residue [active]
889738004180	putative FPP diphosphate  binding site; other site
889738004181	putative FPP binding hydrophobic cleft; other site
889738004182	dimer interface [polypeptide binding]; other site
889738004183	putative IPP diphosphate binding site; other site
889738004184	Cytidylyltransferase family; Region: CTP_transf_1; pfam01148
889738004185	CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575
889738004186	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447
889738004187	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670
889738004188	1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436
889738004189	DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288
889738004190	zinc metallopeptidase RseP; Provisional; Region: PRK10779
889738004191	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
889738004192	active site
889738004193	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
889738004194	protein binding site [polypeptide binding]; other site
889738004195	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
889738004196	protein binding site [polypeptide binding]; other site
889738004197	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
889738004198	putative substrate binding region [chemical binding]; other site
889738004199	outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303
889738004200	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
889738004201	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
889738004202	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
889738004203	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
889738004204	Surface antigen; Region: Bac_surface_Ag; pfam01103
889738004205	Outer membrane protein (OmpH-like); Region: OmpH; pfam03938
889738004206	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892
889738004207	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613
889738004208	UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352
889738004209	trimer interface [polypeptide binding]; other site
889738004210	active site
889738004211	UDP-GlcNAc binding site [chemical binding]; other site
889738004212	lipid binding site [chemical binding]; lipid-binding site
889738004213	FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288
889738004214	UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289
889738004215	UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351
889738004216	active site
889738004217	tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795
889738004218	recombination regulator RecX; Reviewed; Region: recX; PRK00117
889738004219	recombinase A; Provisional; Region: recA; PRK09354
889738004220	RecA is a  bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response.  RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983
889738004221	hexamer interface [polypeptide binding]; other site
889738004222	Walker A motif; other site
889738004223	ATP binding site [chemical binding]; other site
889738004224	Walker B motif; other site
889738004225	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
889738004226	RNA binding surface [nucleotide binding]; other site
889738004227	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915
889738004228	Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419
889738004229	motif II; other site
889738004230	Fels-1 Prophage Protein-like; Region: Fels1; pfam05666
889738004231	Fels-1 Prophage Protein-like; Region: Fels1; pfam05666
889738004232	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
889738004233	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
889738004234	helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344
889738004235	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
889738004236	putative DNA binding site [nucleotide binding]; other site
889738004237	putative Zn2+ binding site [ion binding]; other site
889738004238	AsnC family; Region: AsnC_trans_reg; pfam01037
889738004239	Kynureninase [Amino acid transport and metabolism]; Region: COG3844
889738004240	kynureninase; Region: kynureninase; TIGR01814
889738004241	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
889738004242	catalytic residue [active]
889738004243	Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113
889738004244	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
889738004245	Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922
889738004246	Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404
889738004247	Peptidase S8 family domain in ProteinaseK-like proteins; Region: Peptidases_S8_PCSK9_ProteinaseK_like; cd04077
889738004248	calcium binding site 2 [ion binding]; other site
889738004249	active site
889738004250	catalytic triad [active]
889738004251	calcium binding site 1 [ion binding]; other site
889738004252	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
889738004253	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
889738004254	Sulfate transporter family; Region: Sulfate_transp; pfam00916
889738004255	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
889738004256	Uncharacterized ACR, COG2135; Region: DUF159; pfam02586
889738004257	dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606
889738004258	Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995
889738004259	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
889738004260	Ligand Binding Site [chemical binding]; other site
889738004261	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
889738004262	PAS domain; Region: PAS_9; pfam13426
889738004263	putative active site [active]
889738004264	heme pocket [chemical binding]; other site
889738004265	PAS fold; Region: PAS_4; pfam08448
889738004266	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
889738004267	putative active site [active]
889738004268	heme pocket [chemical binding]; other site
889738004269	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
889738004270	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
889738004271	metal binding site [ion binding]; metal-binding site
889738004272	active site
889738004273	I-site; other site
889738004274	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
889738004275	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
889738004276	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
889738004277	putative DNA binding site [nucleotide binding]; other site
889738004278	putative Zn2+ binding site [ion binding]; other site
889738004279	PTS system fructose-specific transporter subunits IIBC; Provisional; Region: PRK10712
889738004280	PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569
889738004281	active site
889738004282	P-loop; other site
889738004283	phosphorylation site [posttranslational modification]
889738004284	Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; cl17425
889738004285	Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105
889738004286	1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164
889738004287	putative substrate binding site [chemical binding]; other site
889738004288	putative ATP binding site [chemical binding]; other site
889738004289	bifunctional PTS system fructose-specific transporter subunit IIA/HPr protein; Provisional; Region: PRK11109
889738004290	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
889738004291	active site
889738004292	phosphorylation site [posttranslational modification]
889738004293	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cl00163
889738004294	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
889738004295	dimerization domain swap beta strand [polypeptide binding]; other site
889738004296	regulatory protein interface [polypeptide binding]; other site
889738004297	active site
889738004298	regulatory phosphorylation site [posttranslational modification]; other site
889738004299	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
889738004300	Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080
889738004301	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
889738004302	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
889738004303	Predicted alpha/beta hydrolase [General function prediction only]; Region: COG4757
889738004304	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
889738004305	Uncharacterized protein, possibly involved in utilization of glycolate and propanediol [General function prediction only]; Region: GlcG; COG3193
889738004306	Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547
889738004307	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
889738004308	active site
889738004309	LysR family transcriptional regulator; Provisional; Region: PRK14997
889738004310	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
889738004311	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_4; cd08473
889738004312	putative effector binding pocket; other site
889738004313	putative dimerization interface [polypeptide binding]; other site
889738004314	Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028
889738004315	putative GSH binding site [chemical binding]; other site
889738004316	catalytic residues [active]
889738004317	acetylornithine aminotransferase; Provisional; Region: PRK02627
889738004318	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
889738004319	inhibitor-cofactor binding pocket; inhibition site
889738004320	pyridoxal 5'-phosphate binding site [chemical binding]; other site
889738004321	catalytic residue [active]
889738004322	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_10; cd04623
889738004323	FOG: CBS domain [General function prediction only]; Region: COG0517
889738004324	Protein of unknown function (DUF2750); Region: DUF2750; pfam11042
889738004325	signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416
889738004326	SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881
889738004327	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
889738004328	P loop; other site
889738004329	GTP binding site [chemical binding]; other site
889738004330	Nitroreductase-like family 4.  A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_4; cd02140
889738004331	dimer interface [polypeptide binding]; other site
889738004332	FMN binding site [chemical binding]; other site
889738004333	Uncharacterized protein conserved in bacteria (DUF2057); Region: DUF2057; pfam09829
889738004334	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
889738004335	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
889738004336	Coenzyme A binding pocket [chemical binding]; other site
889738004337	Cyd operon protein YbgE (Cyd_oper_YbgE); Region: Cyd_oper_YbgE; pfam09600
889738004338	Membrane bound YbgT-like protein; Region: YbgT_YccB; pfam08173
889738004339	cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219
889738004340	Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322
889738004341	cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097
889738004342	Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562
889738004343	Protein of unknown function (DUF1449); Region: DUF1449; pfam07290
889738004344	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467
889738004345	iron-sulfur cluster [ion binding]; other site
889738004346	[2Fe-2S] cluster binding site [ion binding]; other site
889738004347	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
889738004348	Adenosine kinase (AK) catalyzes the phosphorylation of ribofuranosyl-containing nucleoside analogues at the 5'-hydroxyl using ATP or GTP as the phosphate donor.The physiological function of AK is associated with the regulation of extracellular...; Region: adenosine_kinase; cd01168
889738004349	substrate binding site [chemical binding]; other site
889738004350	ATP binding site [chemical binding]; other site
889738004351	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
889738004352	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
889738004353	N-terminal plug; other site
889738004354	ligand-binding site [chemical binding]; other site
889738004355	Predicted Zn-dependent peptidases, insulinase-like [General function prediction only]; Region: COG1026
889738004356	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
889738004357	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
889738004358	Peptidase M16C associated; Region: M16C_assoc; pfam08367
889738004359	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
889738004360	The outer membrane phospholipase A (OMPLA) is an integral membrane enzyme that catalyses the hydrolysis of acylester bonds in phospholipids using calcium as a cofactor. The enzyme has a fold of transmembrane beta-barrels and is widespread among...; Region: OMPLA; cd00541
889738004361	dimerization interface [polypeptide binding]; other site
889738004362	substrate binding site [chemical binding]; other site
889738004363	active site
889738004364	calcium binding site [ion binding]; other site
889738004365	Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168
889738004366	potassium uptake protein, TrkH family; Region: 2a38; TIGR00933
889738004367	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
889738004368	TrkA-N domain; Region: TrkA_N; pfam02254
889738004369	threonine dehydratase; Reviewed; Region: PRK09224
889738004370	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
889738004371	tetramer interface [polypeptide binding]; other site
889738004372	pyridoxal 5'-phosphate binding site [chemical binding]; other site
889738004373	catalytic residue [active]
889738004374	First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906
889738004375	putative Ile/Val binding site [chemical binding]; other site
889738004376	Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907
889738004377	putative Ile/Val binding site [chemical binding]; other site
889738004378	RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398
889738004379	tetramer (dimer of dimers) interface [polypeptide binding]; other site
889738004380	active site
889738004381	dimer interface [polypeptide binding]; other site
889738004382	Protein of unknown function DUF45; Region: DUF45; pfam01863
889738004383	N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436
889738004384	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
889738004385	Membrane-anchored protein predicted to be involved in regulation of amylopullulanase [Carbohydrate transport and metabolism]; Region: COG4945
889738004386	Uncharacterized conserved protein [Function unknown]; Region: COG2127
889738004387	ATP-dependent Clp protease ATP-binding subunit clpA; Region: ClpA; TIGR02639
889738004388	Clp amino terminal domain; Region: Clp_N; pfam02861
889738004389	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
889738004390	Walker A motif; other site
889738004391	ATP binding site [chemical binding]; other site
889738004392	Walker B motif; other site
889738004393	arginine finger; other site
889738004394	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
889738004395	Walker A motif; other site
889738004396	ATP binding site [chemical binding]; other site
889738004397	Walker B motif; other site
889738004398	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
889738004399	hypothetical protein; Provisional; Region: PRK02237
889738004400	phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12755
889738004401	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
889738004402	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
889738004403	Predicted transcriptional regulators [Transcription]; Region: COG1695
889738004404	Transcriptional regulator PadR-like family; Region: PadR; cl17335
889738004405	Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400
889738004406	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
889738004407	2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli  is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930
889738004408	active site
889738004409	FMN binding site [chemical binding]; other site
889738004410	2,4-decadienoyl-CoA binding site; other site
889738004411	catalytic residue [active]
889738004412	4Fe-4S cluster binding site [ion binding]; other site
889738004413	Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446
889738004414	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
889738004415	SnoaL-like domain; Region: SnoaL_2; pfam12680
889738004416	SGNH_hydrolase subfamily, FeeA, FeeB and similar esterases/lipases. FeeA and FeeB are part of a biosynthetic gene cluster and may participate in the biosynthesis of long-chain N-acyltyrosines by providing saturated and unsaturated fatty acids, which it...; Region: FeeA_FeeB_like; cd01836
889738004417	active site
889738004418	catalytic triad [active]
889738004419	oxyanion hole [active]
889738004420	Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; Region: COG0429
889738004421	Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687
889738004422	Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118
889738004423	CTP synthetase; Validated; Region: pyrG; PRK05380
889738004424	CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113
889738004425	Catalytic site [active]
889738004426	active site
889738004427	UTP binding site [chemical binding]; other site
889738004428	Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746
889738004429	active site
889738004430	putative oxyanion hole; other site
889738004431	catalytic triad [active]
889738004432	2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198
889738004433	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
889738004434	enolase; Provisional; Region: eno; PRK00077
889738004435	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
889738004436	dimer interface [polypeptide binding]; other site
889738004437	metal binding site [ion binding]; metal-binding site
889738004438	substrate binding pocket [chemical binding]; other site
889738004439	Predicted membrane protein [Function unknown]; Region: COG2323
889738004440	Septum formation initiator; Region: DivIC; cl17659
889738004441	Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919
889738004442	CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516
889738004443	substrate binding site; other site
889738004444	dimer interface; other site
889738004445	3-oxoacid CoA-transferase, A subunit; Region: pcaI_scoA_fam; TIGR02429
889738004446	3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428
889738004447	beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050
889738004448	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
889738004449	dimer interface [polypeptide binding]; other site
889738004450	active site
889738004451	3-carboxy-cis,cis-muconate cycloisomerase; Provisional; Region: PRK09053
889738004452	prokaryotic 3-carboxy-cis,cis-muconate cycloisomerase (CMLE)_like; Region: pCLME; cd01597
889738004453	tetramer interface [polypeptide binding]; other site
889738004454	active site
889738004455	3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427
889738004456	benzoate transport; Region: 2A0115; TIGR00895
889738004457	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
889738004458	putative substrate translocation pore; other site
889738004459	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
889738004460	Carboxymuconolactone decarboxylase family; Region: CMD; cl00460
889738004461	Protocatechuate 3,4-dioxygenase (3,4-PCD) , beta subunit. 3,4-PCD catalyzes the oxidative ring cleavage of 3,4-dihydroxybenzoate to produce beta-carboxy-cis,cis-muconate. 3,4-PCDs are large aggregates of 12 protomers, each composed of an alpha- and...; Region: 3,4-PCD_beta; cd03464
889738004462	heterodimer interface [polypeptide binding]; other site
889738004463	multimer interface [polypeptide binding]; other site
889738004464	protocatechuate 3,4-dioxygenase, beta subunit; Region: protocat_beta; TIGR02422
889738004465	active site
889738004466	Protocatechuate 3,4-dioxygenase beta subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PcaH; COG3485
889738004467	Protocatechuate 3,4-dioxygenase (3,4-PCD) , alpha subunit. 3,4-PCD catalyzes the oxidative ring cleavage of 3,4-dihydroxybenzoate to produce beta-carboxy-cis,cis-muconate. 3,4-PCDs are large aggregates of 12 protomers, each composed of an alpha- and...; Region: 3,4-PCD_alpha; cd03463
889738004468	heterodimer interface [polypeptide binding]; other site
889738004469	active site
889738004470	Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502
889738004471	3-dehydroquinate dehydratase [Amino acid transport and metabolism]; Region: AroD; COG0710
889738004472	active site
889738004473	catalytic residue [active]
889738004474	dimer interface [polypeptide binding]; other site
889738004475	Right handed beta helix region; Region: Beta_helix; pfam13229
889738004476	Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966
889738004477	7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695
889738004478	membrane-bound PQQ-dependent dehydrogenase, glucose/quinate/shikimate family; Region: PQQ_membr_DH; TIGR03074
889738004479	Membrane-bound PQQ-dependent glucose dehydrogenase; Region: PQQ_mGDH; cd10280
889738004480	Trp docking motif [polypeptide binding]; other site
889738004481	putative active site [active]
889738004482	Predicted transporter component [General function prediction only]; Region: COG2391
889738004483	Domain of unknown function (DUF4341); Region: DUF4341; pfam14241
889738004484	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
889738004485	beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Region: pcaR_pcaU; TIGR02431
889738004486	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
889738004487	Bacterial transcriptional regulator; Region: IclR; pfam01614
889738004488	Transcriptional regulator [Transcription]; Region: LysR; COG0583
889738004489	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
889738004490	The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417
889738004491	substrate binding pocket [chemical binding]; other site
889738004492	dimerization interface [polypeptide binding]; other site
889738004493	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
889738004494	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
889738004495	active site
889738004496	thiamine kinase; Region: ycfN_thiK; TIGR02721
889738004497	Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154
889738004498	putative active site [active]
889738004499	putative substrate binding site [chemical binding]; other site
889738004500	ATP binding site [chemical binding]; other site
889738004501	Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040
889738004502	catalytic core [active]
889738004503	short chain dehydrogenase; Provisional; Region: PRK08251
889738004504	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
889738004505	NAD(P) binding site [chemical binding]; other site
889738004506	active site
889738004507	outer membrane porin, OprD family; Region: OprD; pfam03573
889738004508	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
889738004509	Major Facilitator Superfamily; Region: MFS_1; pfam07690
889738004510	putative substrate translocation pore; other site
889738004511	Transcriptional regulators [Transcription]; Region: MarR; COG1846
889738004512	Winged helix DNA-binding domain; Region: HTH_27; pfam13463
889738004513	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
889738004514	Amidase; Region: Amidase; cl11426
889738004515	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
889738004516	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
889738004517	active site
889738004518	SnoaL-like domain; Region: SnoaL_4; pfam13577
889738004519	benzoate 1,2-dioxygenase, large subunit; Region: benzo_1_2_benA; TIGR03229
889738004520	Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469
889738004521	[2Fe-2S] cluster binding site [ion binding]; other site
889738004522	C-terminal catalytic domain of the oxygenase alpha subunit of Pseudomonas resinovorans strain CA10 anthranilate 1,2-dioxygenase and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_AntDO-like; cd08879
889738004523	putative alpha subunit interface [polypeptide binding]; other site
889738004524	putative active site [active]
889738004525	putative substrate binding site [chemical binding]; other site
889738004526	Fe binding site [ion binding]; other site
889738004527	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
889738004528	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
889738004529	classical (c) SDRs; Region: SDR_c; cd05233
889738004530	NAD(P) binding site [chemical binding]; other site
889738004531	active site
889738004532	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
889738004533	Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal  ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185
889738004534	FMN-binding pocket [chemical binding]; other site
889738004535	flavin binding motif; other site
889738004536	phosphate binding motif [ion binding]; other site
889738004537	beta-alpha-beta structure motif; other site
889738004538	NAD binding pocket [chemical binding]; other site
889738004539	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
889738004540	catalytic loop [active]
889738004541	iron binding site [ion binding]; other site
889738004542	Flavin reductase like domain; Region: Flavin_Reduct; smart00903
889738004543	DNA-binding transcriptional activator FeaR; Provisional; Region: PRK09685
889738004544	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
889738004545	tyramine oxidase; Provisional; Region: tynA; PRK14696
889738004546	Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833
889738004547	Copper amine oxidase, N3 domain; Region: Cu_amine_oxidN3; pfam02728
889738004548	Copper amine oxidase, enzyme domain; Region: Cu_amine_oxid; pfam01179
889738004549	Escherichia coli NAD+-dependent phenylacetaldehyde dehydrogenase PadA-like; Region: ALDH_PADH_NahF; cd07113
889738004550	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
889738004551	NAD(P) binding site [chemical binding]; other site
889738004552	catalytic residues [active]
889738004553	Protein related to penicillin acylase [General function prediction only]; Region: COG2366
889738004554	The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid.  N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467
889738004555	The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid.  N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467
889738004556	active site
889738004557	3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427
889738004558	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
889738004559	beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050
889738004560	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
889738004561	dimer interface [polypeptide binding]; other site
889738004562	active site
889738004563	3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428
889738004564	3-oxoacid CoA-transferase, A subunit; Region: pcaI_scoA_fam; TIGR02429
889738004565	catechol 1,2-dioxygenase, proteobacterial; Region: catechol_proteo; TIGR02439
889738004566	Catechol 1,2 dioxygenase (1,2-CTD) catalyzes an intradiol cleavage reaction of catechol to form cis,cis-muconate. 1,2-CTDs is homodimers with one catalytic non-heme ferric ion per monomer. They belong to the aromatic dioxygenase family, a family of...; Region: 1,2-CTD; cd03460
889738004567	dimer interface [polypeptide binding]; other site
889738004568	active site
889738004569	muconolactone delta-isomerase; Region: muco_delta; TIGR03221
889738004570	muconate and chloromuconate cycloisomerases; Region: mucon_cyclo; TIGR02534
889738004571	Muconate Lactonizing Enzyme (MLE), an homooctameric enzyme, catalyses the conversion of cis,cis-muconate (CCM) to muconolactone (ML) in the catechol branch of the beta-ketoadipate pathway. This pathway is used in soil microbes to breakdown lignin-derived...; Region: MLE; cd03318
889738004572	octamer interface [polypeptide binding]; other site
889738004573	active site
889738004574	DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906
889738004575	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
889738004576	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
889738004577	dimerization interface [polypeptide binding]; other site
889738004578	Bacterial protein of unknown function (Gcw_chp); Region: Gcw_chp; pfam09694
889738004579	Transcriptional regulators [Transcription]; Region: FadR; COG2186
889738004580	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
889738004581	DNA-binding site [nucleotide binding]; DNA binding site
889738004582	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
889738004583	dihydroxy-acid dehydratase; Validated; Region: PRK06131
889738004584	4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332
889738004585	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
889738004586	putative substrate translocation pore; other site
889738004587	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
889738004588	Uncharacterized protein conserved in bacteria [Function unknown]; Region: GguC; COG3802
889738004589	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
889738004590	NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012
889738004591	Alpha-Ketoglutaric Semialdehyde Dehydrogenase; Region: ALDH_KGSADH; cd07129
889738004592	dimer interface [polypeptide binding]; other site
889738004593	NADP binding site [chemical binding]; other site
889738004594	catalytic residues [active]
889738004595	Phosphotransferase enzyme family; Region: APH; pfam01636
889738004596	Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154
889738004597	putative active site [active]
889738004598	putative substrate binding site [chemical binding]; other site
889738004599	ATP binding site [chemical binding]; other site
889738004600	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
889738004601	catalytic core [active]
889738004602	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
889738004603	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
889738004604	active site
889738004605	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
889738004606	classical (c) SDRs; Region: SDR_c; cd05233
889738004607	NAD(P) binding site [chemical binding]; other site
889738004608	active site
889738004609	Propionate catabolism activator; Region: PrpR_N; pfam06506
889738004610	psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974
889738004611	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
889738004612	Walker A motif; other site
889738004613	ATP binding site [chemical binding]; other site
889738004614	Walker B motif; other site
889738004615	arginine finger; other site
889738004616	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
889738004617	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07008
889738004618	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
889738004619	acyl-activating enzyme (AAE) consensus motif; other site
889738004620	AMP binding site [chemical binding]; other site
889738004621	active site
889738004622	CoA binding site [chemical binding]; other site
889738004623	Protein of unknown function, DUF485; Region: DUF485; pfam04341
889738004624	Predicted symporter [General function prediction only]; Region: DhlC; COG4147
889738004625	Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480
889738004626	Na binding site [ion binding]; other site
889738004627	putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824
889738004628	PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276
889738004629	NAD(P) binding site [chemical binding]; other site
889738004630	aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381
889738004631	Coniferyl aldehyde dehydrogenase-like; Region: ALDH_CALDH_CalB; cd07133
889738004632	NAD(P) binding site [chemical binding]; other site
889738004633	catalytic residues [active]
889738004634	Acetoacetate decarboxylase (ADC); Region: ADC; cl01919
889738004635	Partial alpha/beta-hydrolase lipase region; Region: Abhydro_lipase; pfam04083
889738004636	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
889738004637	Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753
889738004638	Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156
889738004639	tetramer interface [polypeptide binding]; other site
889738004640	heme binding pocket [chemical binding]; other site
889738004641	NADPH binding site [chemical binding]; other site
889738004642	2-oxoglutarate dehydrogenase E2 component; Region: PLN02226
889738004643	Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141
889738004644	Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693
889738004645	potential catalytic triad [active]
889738004646	conserved cys residue [active]
889738004647	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
889738004648	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
889738004649	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
889738004650	MarR family; Region: MarR; pfam01047
889738004651	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
889738004652	Old yellow enzyme (OYE)-related FMN binding domain, group 2.  Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_2_FMN; cd04733
889738004653	putative active site [active]
889738004654	putative FMN binding site [chemical binding]; other site
889738004655	putative substrate binding site [chemical binding]; other site
889738004656	putative catalytic residue [active]
889738004657	Uncharacterized conserved protein [Function unknown]; Region: COG3268
889738004658	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
889738004659	NAD(P) binding site [chemical binding]; other site
889738004660	RibD C-terminal domain; Region: RibD_C; cl17279
889738004661	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
889738004662	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
889738004663	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
889738004664	DNA binding residues [nucleotide binding]
889738004665	Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693
889738004666	Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141
889738004667	potential catalytic triad [active]
889738004668	conserved cys residue [active]
889738004669	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
889738004670	Transcriptional regulator; Region: Rrf2; pfam02082
889738004671	Rrf2 family protein; Region: rrf2_super; TIGR00738
889738004672	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
889738004673	Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706
889738004674	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
889738004675	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
889738004676	Uncharacterized conserved protein [Function unknown]; Region: COG1359
889738004677	Isochorismatase family; Region: Isochorismatase; pfam00857
889738004678	YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012
889738004679	catalytic triad [active]
889738004680	dimer interface [polypeptide binding]; other site
889738004681	conserved cis-peptide bond; other site
889738004682	LysR family transcriptional regulator; Provisional; Region: PRK14997
889738004683	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
889738004684	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_4; cd08473
889738004685	putative effector binding pocket; other site
889738004686	putative dimerization interface [polypeptide binding]; other site
889738004687	dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606
889738004688	Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995
889738004689	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
889738004690	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
889738004691	Kef-type K+ transport systems, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: Kch; COG1226
889738004692	TrkA-N domain; Region: TrkA_N; pfam02254
889738004693	M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like2; cd05667
889738004694	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
889738004695	metal binding site [ion binding]; metal-binding site
889738004696	putative dimer interface [polypeptide binding]; other site
889738004697	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
889738004698	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
889738004699	Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831
889738004700	POTRA domain, ShlB-type; Region: POTRA_2; pfam08479
889738004701	Haemolysin secretion/activation protein ShlB/FhaC/HecB; Region: ShlB; pfam03865
889738004702	haemagglutination activity domain; Region: Haemagg_act; pfam05860
889738004703	Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; cl01733
889738004704	Possible hemagglutinin (DUF637); Region: DUF637; pfam04830
889738004705	Pre-toxin domain with VENN motif; Region: PT-VENN; pfam04829
889738004706	MafB19-like deaminase; Region: MafB19-deam; pfam14437
889738004707	4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332
889738004708	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
889738004709	putative substrate translocation pore; other site
889738004710	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
889738004711	Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618
889738004712	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
889738004713	active site
889738004714	Dicarboxylate carrier protein MatC N-terminus; Region: MatC_N; pfam07158
889738004715	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
889738004716	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221
889738004717	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
889738004718	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
889738004719	DNA-binding site [nucleotide binding]; DNA binding site
889738004720	The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866
889738004721	SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450
889738004722	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567
889738004723	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
889738004724	putative substrate translocation pore; other site
889738004725	Major Facilitator Superfamily; Region: MFS_1; pfam07690
889738004726	Transcriptional regulator [Transcription]; Region: LysR; COG0583
889738004727	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
889738004728	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
889738004729	putative effector binding pocket; other site
889738004730	dimerization interface [polypeptide binding]; other site
889738004731	Protein of unknown function, DUF606; Region: DUF606; pfam04657
889738004732	Protein of unknown function, DUF606; Region: DUF606; pfam04657
889738004733	IclR helix-turn-helix domain; Region: HTH_IclR; cl17605
889738004734	Transcriptional regulator [Transcription]; Region: IclR; COG1414
889738004735	Bacterial transcriptional regulator; Region: IclR; pfam01614
889738004736	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
889738004737	Major Facilitator Superfamily; Region: MFS_1; pfam07690
889738004738	putative substrate translocation pore; other site
889738004739	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
889738004740	Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173
889738004741	ligand binding site [chemical binding]; other site
889738004742	NAD binding site [chemical binding]; other site
889738004743	dimerization interface [polypeptide binding]; other site
889738004744	catalytic site [active]
889738004745	hypothetical protein; Validated; Region: PRK06201
889738004746	Demethylmenaquinone methyltransferase [Coenzyme metabolism]; Region: MenG; COG0684
889738004747	Antitoxin of toxin-antitoxin stability system N-terminal; Region: RelB_N; pfam12910
889738004748	RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931
889738004749	type I secretion C-terminal target domain (VC_A0849 subclass); Region: T1SS_VCA0849; TIGR03661
889738004750	Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566
889738004751	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
889738004752	HlyD family secretion protein; Region: HlyD_3; pfam13437
889738004753	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
889738004754	putative substrate translocation pore; other site
889738004755	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
889738004756	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
889738004757	AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246
889738004758	NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012
889738004759	Alpha-Ketoglutaric Semialdehyde Dehydrogenase; Region: ALDH_KGSADH; cd07129
889738004760	dimer interface [polypeptide binding]; other site
889738004761	NADP binding site [chemical binding]; other site
889738004762	catalytic residues [active]
889738004763	dihydroxy-acid dehydratase; Provisional; Region: PRK13017
889738004764	Fumarylacetoacetate (FAA) hydrolase family protein [General function prediction only]; Region: COG3970
889738004765	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
889738004766	Transcriptional regulator [Transcription]; Region: LysR; COG0583
889738004767	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
889738004768	The C-terminal substrate binding domain of galactose-binding protein regulator contains the type 2 periplasmic binding fold; Region: PBP2_GbpR; cd08435
889738004769	putative dimerization interface [polypeptide binding]; other site
889738004770	4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332
889738004771	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
889738004772	putative substrate translocation pore; other site
889738004773	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
889738004774	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
889738004775	AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719
889738004776	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
889738004777	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
889738004778	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
889738004779	Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917
889738004780	Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599
889738004781	Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599
889738004782	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
889738004783	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283
889738004784	putative NAD(P) binding site [chemical binding]; other site
889738004785	putative substrate binding site [chemical binding]; other site
889738004786	catalytic Zn binding site [ion binding]; other site
889738004787	structural Zn binding site [ion binding]; other site
889738004788	dimer interface [polypeptide binding]; other site
889738004789	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
889738004790	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
889738004791	intersubunit interface [polypeptide binding]; other site
889738004792	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
889738004793	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
889738004794	ABC-ATPase subunit  interface; other site
889738004795	dimer interface [polypeptide binding]; other site
889738004796	putative PBP binding regions; other site
889738004797	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
889738004798	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
889738004799	Walker A/P-loop; other site
889738004800	ATP binding site [chemical binding]; other site
889738004801	Q-loop/lid; other site
889738004802	ABC transporter signature motif; other site
889738004803	Walker B; other site
889738004804	D-loop; other site
889738004805	H-loop/switch region; other site
889738004806	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
889738004807	Coenzyme A binding pocket [chemical binding]; other site
889738004808	Cupin domain; Region: Cupin_2; cl17218
889738004809	Helix-turn-helix domain; Region: HTH_18; pfam12833
889738004810	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
889738004811	Phosphoribosylpyrophosphate synthetase [Nucleotide transport and metabolism / Amino acid transport and metabolism]; Region: PrsA; COG0462
889738004812	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
889738004813	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
889738004814	active site
889738004815	putative nicotinate phosphoribosyltransferase; Provisional; Region: PRK09198
889738004816	pre-B-cell colony-enhancing factor (PBEF)-like. The mammalian members of this group of nicotinate phosphoribosyltransferases (NAPRTases) were originally identified as genes whose expression is upregulated upon activation in lymphoid cells. In general; Region: PBEF_like; cd01569
889738004817	active site
889738004818	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883
889738004819	nudix motif; other site
889738004820	Uncharacterized conserved protein [General function prediction only]; Region: COG4111
889738004821	Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cl00246
889738004822	FAD binding site [chemical binding]; other site
889738004823	Methylene-tetrahydrofolate reductase C terminal; Region: MTHFR_C; pfam12225
889738004824	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
889738004825	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
889738004826	DNA binding residues [nucleotide binding]
889738004827	dimerization interface [polypeptide binding]; other site
889738004828	indole acetimide hydrolase; Validated; Region: PRK07488
889738004829	Amidase; Region: Amidase; pfam01425
889738004830	Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566
889738004831	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
889738004832	HlyD family secretion protein; Region: HlyD_3; pfam13437
889738004833	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
889738004834	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
889738004835	putative substrate translocation pore; other site
889738004836	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
889738004837	GH3 auxin-responsive promoter; Region: GH3; pfam03321
889738004838	type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844
889738004839	Survival protein SurE; Region: SurE; pfam01975
889738004840	HD domain; Region: HD_4; pfam13328
889738004841	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
889738004842	non-specific DNA binding site [nucleotide binding]; other site
889738004843	salt bridge; other site
889738004844	sequence-specific DNA binding site [nucleotide binding]; other site
889738004845	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
889738004846	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
889738004847	Phage antirepressor protein KilAC domain; Region: ANT; pfam03374
889738004848	PAAR motif; Region: PAAR_motif; pfam05488
889738004849	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
889738004850	classical (c) SDRs; Region: SDR_c; cd05233
889738004851	NAD(P) binding site [chemical binding]; other site
889738004852	active site
889738004853	Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028
889738004854	classical (c) SDRs; Region: SDR_c; cd05233
889738004855	NAD(P) binding site [chemical binding]; other site
889738004856	active site
889738004857	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
889738004858	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
889738004859	Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625
889738004860	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220
889738004861	dimerization interface [polypeptide binding]; other site
889738004862	putative DNA binding site [nucleotide binding]; other site
889738004863	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
889738004864	putative Zn2+ binding site [ion binding]; other site
889738004865	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
889738004866	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
889738004867	dimerization interface [polypeptide binding]; other site
889738004868	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
889738004869	dimer interface [polypeptide binding]; other site
889738004870	phosphorylation site [posttranslational modification]
889738004871	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
889738004872	ATP binding site [chemical binding]; other site
889738004873	Mg2+ binding site [ion binding]; other site
889738004874	G-X-G motif; other site
889738004875	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
889738004876	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
889738004877	active site
889738004878	phosphorylation site [posttranslational modification]
889738004879	intermolecular recognition site; other site
889738004880	dimerization interface [polypeptide binding]; other site
889738004881	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
889738004882	DNA binding site [nucleotide binding]
889738004883	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
889738004884	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
889738004885	HlyD family secretion protein; Region: HlyD_3; pfam13437
889738004886	The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915
889738004887	Protein export membrane protein; Region: SecD_SecF; cl14618
889738004888	Protein export membrane protein; Region: SecD_SecF; cl14618
889738004889	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
889738004890	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
889738004891	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
889738004892	alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561
889738004893	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
889738004894	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
889738004895	Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593
889738004896	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
889738004897	Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748
889738004898	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
889738004899	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
889738004900	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
889738004901	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
889738004902	Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; cl17479
889738004903	P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539
889738004904	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
889738004905	P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121
889738004906	Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345
889738004907	Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753
889738004908	P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188
889738004909	PapC N-terminal domain; Region: PapC_N; pfam13954
889738004910	Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577
889738004911	PapC C-terminal domain; Region: PapC_C; pfam13953
889738004912	P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539
889738004913	class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300
889738004914	S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase; Region: adh_III_F_hyde; TIGR02818
889738004915	substrate binding site [chemical binding]; other site
889738004916	catalytic Zn binding site [ion binding]; other site
889738004917	NAD binding site [chemical binding]; other site
889738004918	structural Zn binding site [ion binding]; other site
889738004919	dimer interface [polypeptide binding]; other site
889738004920	Catalase-like heme-binding proteins similar to the uncharacterized y4iL; Region: y4iL_like; cd08152
889738004921	putative heme binding pocket [chemical binding]; other site
889738004922	Putative catalytic domain, repeat 1, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_1; cd09111
889738004923	PLD-like domain; Region: PLDc_2; pfam13091
889738004924	putative active site [active]
889738004925	catalytic site [active]
889738004926	Putative catalytic domain, repeat 2, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_2; cd09113
889738004927	PLD-like domain; Region: PLDc_2; pfam13091
889738004928	putative active site [active]
889738004929	catalytic site [active]
889738004930	MUG-like Uracil-DNA glycosylase enzyme family; Region: UDG_MUG_like; cd10032
889738004931	putative active site [active]
889738004932	Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355
889738004933	renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301
889738004934	active site
889738004935	dimer interface [polypeptide binding]; other site
889738004936	pyrroloquinoline quinone biosynthesis protein PqqE; Provisional; Region: PRK05301
889738004937	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
889738004938	FeS/SAM binding site; other site
889738004939	radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085
889738004940	pyrroloquinoline quinone biosynthesis protein PqqD; Provisional; Region: PRK02079
889738004941	pyrroloquinoline quinone biosynthesis protein PqqC; Provisional; Region: PRK05157
889738004942	pyrroloquinoline quinone biosynthesis protein PqqB; Provisional; Region: PRK05184
889738004943	coenzyme PQQ biosynthesis protein B; Region: PQQ_syn_pqqB; TIGR02108
889738004944	polyphosphate kinase; Provisional; Region: PRK05443
889738004945	Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089
889738004946	Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503
889738004947	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
889738004948	putative active site [active]
889738004949	catalytic site [active]
889738004950	Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168
889738004951	putative domain interface [polypeptide binding]; other site
889738004952	putative active site [active]
889738004953	catalytic site [active]
889738004954	5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737
889738004955	Bacillus subtilis YhcR endonuclease and related proteins, N-terminal metallophosphatase domain; Region: MPP_YhcR_N; cd07412
889738004956	putative active site [active]
889738004957	putative metal binding site [ion binding]; other site
889738004958	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
889738004959	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cl17326
889738004960	metal binding site 2 [ion binding]; metal-binding site
889738004961	putative DNA binding helix; other site
889738004962	metal binding site 1 [ion binding]; metal-binding site
889738004963	dimer interface [polypeptide binding]; other site
889738004964	structural Zn2+ binding site [ion binding]; other site
889738004965	Isochorismatase, also known as 2,3 dihydro-2,3 dihydroxybenzoate synthase, catalyses the conversion of isochorismate, in the presence of water, to 2,3-dihydroxybenzoate and pyruvate, via the hydrolysis of a vinyl ether, an uncommon reaction in biological...; Region: isochorismatase; cd01013
889738004966	hydrophobic substrate binding pocket; other site
889738004967	Isochorismatase family; Region: Isochorismatase; pfam00857
889738004968	active site
889738004969	conserved cis-peptide bond; other site
889738004970	2,3-dihydroxybenzoate-2,3-dehydrogenase; Validated; Region: PRK08220
889738004971	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
889738004972	NAD(P) binding site [chemical binding]; other site
889738004973	active site
889738004974	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
889738004975	phosphonate C-P lyase system protein PhnL; Region: CP_lyasePhnL; TIGR02324
889738004976	Walker A/P-loop; other site
889738004977	ATP binding site [chemical binding]; other site
889738004978	Q-loop/lid; other site
889738004979	ABC transporter signature motif; other site
889738004980	Walker B; other site
889738004981	D-loop; other site
889738004982	H-loop/switch region; other site
889738004983	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
889738004984	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
889738004985	dimer interface [polypeptide binding]; other site
889738004986	conserved gate region; other site
889738004987	putative PBP binding loops; other site
889738004988	ABC-ATPase subunit interface; other site
889738004989	molybdate transporter periplasmic protein; Provisional; Region: modA; PRK10677
889738004990	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
889738004991	N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; cl17549
889738004992	anthranilate 1,2-dioxygenase, large subunit; Region: anthran_1_2_A; TIGR03228
889738004993	Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469
889738004994	[2Fe-2S] cluster binding site [ion binding]; other site
889738004995	C-terminal catalytic domain of the oxygenase alpha subunit of Pseudomonas resinovorans strain CA10 anthranilate 1,2-dioxygenase and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_AntDO-like; cd08879
889738004996	putative alpha subunit interface [polypeptide binding]; other site
889738004997	putative active site [active]
889738004998	putative substrate binding site [chemical binding]; other site
889738004999	Fe binding site [ion binding]; other site
889738005000	Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667
889738005001	inter-subunit interface; other site
889738005002	anthranilate dioxygenase reductase; Provisional; Region: antC; PRK11872
889738005003	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
889738005004	catalytic loop [active]
889738005005	iron binding site [ion binding]; other site
889738005006	Benzoate dioxygenase reductase (BenDO) FAD/NAD binding domain. Oxygenases oxidize hydrocarbons using dioxygen as the oxidant. As a Class I bacterial dioxygenases, benzoate dioxygenase like proteins combine an [2Fe-2S] cluster containing N-terminal...; Region: BenDO_FAD_NAD; cd06209
889738005007	FAD binding pocket [chemical binding]; other site
889738005008	FAD binding motif [chemical binding]; other site
889738005009	phosphate binding motif [ion binding]; other site
889738005010	beta-alpha-beta structure motif; other site
889738005011	NAD binding pocket [chemical binding]; other site
889738005012	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
889738005013	Helix-turn-helix domain; Region: HTH_18; pfam12833
889738005014	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
889738005015	Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; cl01768
889738005016	Flavin reductase like domain; Region: Flavin_Reduct; smart00903
889738005017	short chain dehydrogenase; Provisional; Region: PRK08265
889738005018	classical (c) SDRs; Region: SDR_c; cd05233
889738005019	NAD(P) binding site [chemical binding]; other site
889738005020	active site
889738005021	Dienelactone hydrolase family; Region: DLH; pfam01738
889738005022	SnoaL-like domain; Region: SnoaL_2; pfam12680
889738005023	benzoate transport; Region: 2A0115; TIGR00895
889738005024	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
889738005025	putative substrate translocation pore; other site
889738005026	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
889738005027	Helix-turn-helix domain; Region: HTH_18; pfam12833
889738005028	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
889738005029	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
889738005030	3-hydroxybutyrate dehydrogenase; Provisional; Region: PRK12429
889738005031	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
889738005032	NAD(P) binding site [chemical binding]; other site
889738005033	active site
889738005034	H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610
889738005035	fructuronate transporter; Provisional; Region: PRK10034; cl15264
889738005036	Transcriptional regulator [Transcription]; Region: LysR; COG0583
889738005037	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
889738005038	TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440
889738005039	putative dimerization interface [polypeptide binding]; other site
889738005040	Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788
889738005041	3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428
889738005042	Short chain fatty acids transporter [Lipid metabolism]; Region: AtoE; COG2031
889738005043	acetyl-CoA acetyltransferase; Provisional; Region: PRK06954
889738005044	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
889738005045	dimer interface [polypeptide binding]; other site
889738005046	active site
889738005047	Transcriptional regulator [Transcription]; Region: LysR; COG0583
889738005048	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
889738005049	The C-terminal substrate binding domain of LysR-type transcriptional regulators that are involved in the catabolism of dinitrotoluene, naphthalene and gamma-hexachlorohexane; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_NahR_LinR_like; cd08459
889738005050	substrate binding pocket [chemical binding]; other site
889738005051	dimerization interface [polypeptide binding]; other site
889738005052	cell density-dependent motility repressor; Provisional; Region: PRK10082
889738005053	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
889738005054	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
889738005055	dimerization interface [polypeptide binding]; other site
889738005056	aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273
889738005057	Aspartase; Region: Aspartase; cd01357
889738005058	active sites [active]
889738005059	tetramer interface [polypeptide binding]; other site
889738005060	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
889738005061	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
889738005062	N-terminal plug; other site
889738005063	ligand-binding site [chemical binding]; other site
889738005064	alpha-ketoglutarate transporter; Provisional; Region: PRK10406
889738005065	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
889738005066	putative substrate translocation pore; other site
889738005067	Protein of unknown function (DUF971); Region: DUF971; pfam06155
889738005068	HEAT repeats; Region: HEAT_2; pfam13646
889738005069	HEAT repeats; Region: HEAT_2; pfam13646
889738005070	HEAT repeats; Region: HEAT_2; pfam13646
889738005071	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
889738005072	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
889738005073	Walker A/P-loop; other site
889738005074	ATP binding site [chemical binding]; other site
889738005075	Q-loop/lid; other site
889738005076	ABC transporter signature motif; other site
889738005077	Walker B; other site
889738005078	D-loop; other site
889738005079	H-loop/switch region; other site
889738005080	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
889738005081	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
889738005082	dimer interface [polypeptide binding]; other site
889738005083	conserved gate region; other site
889738005084	putative PBP binding loops; other site
889738005085	ABC-ATPase subunit interface; other site
889738005086	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432
889738005087	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
889738005088	substrate binding pocket [chemical binding]; other site
889738005089	membrane-bound complex binding site; other site
889738005090	Ferredoxin [Energy production and conversion]; Region: COG1146
889738005091	putative oxidoreductase; Provisional; Region: PRK08275
889738005092	L-aspartate oxidase; Provisional; Region: PRK06175
889738005093	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
889738005094	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
889738005095	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
889738005096	DNA-binding site [nucleotide binding]; DNA binding site
889738005097	UTRA domain; Region: UTRA; pfam07702
889738005098	Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059
889738005099	chromate transporter, chromate ion transporter (CHR) family; Region: 2A51; TIGR00937
889738005100	Chromate transporter; Region: Chromate_transp; pfam02417
889738005101	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
889738005102	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
889738005103	Predicted transcriptional regulators [Transcription]; Region: COG1733
889738005104	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
889738005105	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
889738005106	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
889738005107	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
889738005108	EamA-like transporter family; Region: EamA; pfam00892
889738005109	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
889738005110	EamA-like transporter family; Region: EamA; pfam00892
889738005111	Homoserine dehydrogenase [Amino acid transport and metabolism]; Region: ThrA; COG0460
889738005112	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
889738005113	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
889738005114	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
889738005115	Putative phosphatase (DUF442); Region: DUF442; cl17385
889738005116	Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446
889738005117	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
889738005118	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
889738005119	psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974
889738005120	Walker A motif; other site
889738005121	ATP binding site [chemical binding]; other site
889738005122	Walker B motif; other site
889738005123	arginine finger; other site
889738005124	Bestrophin, RFP-TM, chloride channel; Region: Bestrophin; pfam01062
889738005125	(2R,3R)-2,3-butanediol dehydrogenase; Region: butanediol_DH_like; cd08233
889738005126	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
889738005127	putative NAD(P) binding site [chemical binding]; other site
889738005128	catalytic Zn binding site [ion binding]; other site
889738005129	meso-2,3-butanediol dehydrogenase-like, classical (c) SDRs; Region: meso-BDH-like_SDR_c; cd05366
889738005130	acetoin reductases; Region: 23BDH; TIGR02415
889738005131	NAD binding site [chemical binding]; other site
889738005132	homotetramer interface [polypeptide binding]; other site
889738005133	homodimer interface [polypeptide binding]; other site
889738005134	active site
889738005135	substrate binding site [chemical binding]; other site
889738005136	dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416
889738005137	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
889738005138	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
889738005139	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
889738005140	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
889738005141	pyruvate dehydrogenase complex dihydrolipoamide acetyltransferase, long form; Region: PDHac_trf_mito; TIGR01349
889738005142	E3 interaction surface; other site
889738005143	lipoyl attachment site [posttranslational modification]; other site
889738005144	e3 binding domain; Region: E3_binding; pfam02817
889738005145	e3 binding domain; Region: E3_binding; pfam02817
889738005146	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
889738005147	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022
889738005148	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
889738005149	alpha subunit interface [polypeptide binding]; other site
889738005150	TPP binding site [chemical binding]; other site
889738005151	heterodimer interface [polypeptide binding]; other site
889738005152	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
889738005153	pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182
889738005154	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
889738005155	tetramer interface [polypeptide binding]; other site
889738005156	TPP-binding site [chemical binding]; other site
889738005157	heterodimer interface [polypeptide binding]; other site
889738005158	phosphorylation loop region [posttranslational modification]
889738005159	lipoyl synthase; Provisional; Region: PRK12928
889738005160	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
889738005161	FeS/SAM binding site; other site
889738005162	Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862
889738005163	TENA/THI-4/PQQC family; Region: TENA_THI-4; cl15243
889738005164	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
889738005165	metal binding site [ion binding]; metal-binding site
889738005166	active site
889738005167	I-site; other site
889738005168	Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082
889738005169	Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304
889738005170	Tetramer interface [polypeptide binding]; other site
889738005171	active site
889738005172	FMN-binding site [chemical binding]; other site
889738005173	HemK family putative methylases; Region: hemK_fam; TIGR00536
889738005174	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
889738005175	S-adenosylmethionine binding site [chemical binding]; other site
889738005176	tryptophan synthase, beta subunit; Region: trpB; TIGR00263
889738005177	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
889738005178	pyridoxal 5'-phosphate binding site [chemical binding]; other site
889738005179	catalytic residue [active]
889738005180	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3825
889738005181	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
889738005182	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
889738005183	Walker A motif; other site
889738005184	ATP binding site [chemical binding]; other site
889738005185	Walker B motif; other site
889738005186	arginine finger; other site
889738005187	YcgL domain; Region: YcgL; pfam05166
889738005188	Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349
889738005189	DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142
889738005190	catalytic site [active]
889738005191	putative active site [active]
889738005192	putative substrate binding site [chemical binding]; other site
889738005193	HRDC domain; Region: HRDC; pfam00570
889738005194	recombination protein RecR; Reviewed; Region: recR; PRK00076
889738005195	RecR protein; Region: RecR; pfam02132
889738005196	TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR.  RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025
889738005197	putative active site [active]
889738005198	putative metal-binding site [ion binding]; other site
889738005199	tetramer interface [polypeptide binding]; other site
889738005200	hypothetical protein; Validated; Region: PRK00153
889738005201	O-succinylhomoserine sulfhydrylase; Validated; Region: PRK08133
889738005202	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
889738005203	homodimer interface [polypeptide binding]; other site
889738005204	substrate-cofactor binding pocket; other site
889738005205	pyridoxal 5'-phosphate binding site [chemical binding]; other site
889738005206	catalytic residue [active]
889738005207	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
889738005208	Methyltransferase domain; Region: Methyltransf_23; pfam13489
889738005209	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
889738005210	S-adenosylmethionine binding site [chemical binding]; other site
889738005211	TonB C terminal; Region: TonB_2; pfam13103
889738005212	Uncharacterized conserved protein [Function unknown]; Region: COG3791
889738005213	HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277
889738005214	HIT family signature motif; other site
889738005215	catalytic residue [active]
889738005216	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
889738005217	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
889738005218	eyelet of channel; other site
889738005219	trimer interface [polypeptide binding]; other site
889738005220	Bacterial protein of unknown function (DUF937); Region: DUF937; cl01528
889738005221	Protein of unknown function (DUF2797); Region: DUF2797; pfam10977
889738005222	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
889738005223	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
889738005224	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
889738005225	ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679
889738005226	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
889738005227	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
889738005228	Walker A/P-loop; other site
889738005229	ATP binding site [chemical binding]; other site
889738005230	Q-loop/lid; other site
889738005231	ABC transporter signature motif; other site
889738005232	Walker B; other site
889738005233	D-loop; other site
889738005234	H-loop/switch region; other site
889738005235	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
889738005236	ATP-binding cassette domain of the lipid transporters, subfamily A; Region: ABC_subfamily_A; cd03263
889738005237	Walker A/P-loop; other site
889738005238	ATP binding site [chemical binding]; other site
889738005239	Q-loop/lid; other site
889738005240	ABC transporter signature motif; other site
889738005241	Walker B; other site
889738005242	D-loop; other site
889738005243	H-loop/switch region; other site
889738005244	putative efflux pump membrane fusion protein; Provisional; Region: PRK03598
889738005245	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
889738005246	HlyD family secretion protein; Region: HlyD_3; pfam13437
889738005247	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
889738005248	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
889738005249	Domain of unknown function (DUF1956); Region: DUF1956; pfam09209
889738005250	lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025
889738005251	ipid-A-disaccharide synthase; Provisional; Region: PRK14089
889738005252	Outer membrane receptor for ferric coprogen and ferric-rhodotorulic acid [Inorganic ion transport and metabolism]; Region: FhuE; COG4773
889738005253	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
889738005254	N-terminal plug; other site
889738005255	ligand-binding site [chemical binding]; other site
889738005256	Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182
889738005257	PepSY-associated TM helix; Region: PepSY_TM_3; pfam13706
889738005258	PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703
889738005259	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
889738005260	phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261
889738005261	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
889738005262	cobalamin synthase; Reviewed; Region: cobS; PRK00235
889738005263	Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061
889738005264	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
889738005265	catalytic core [active]
889738005266	Phosphoribosyltransferase; Region: DBI_PRT; pfam02277
889738005267	Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439
889738005268	putative dimer interface [polypeptide binding]; other site
889738005269	active site pocket [active]
889738005270	putative cataytic base [active]
889738005271	Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544
889738005272	homotrimer interface [polypeptide binding]; other site
889738005273	Walker A motif; other site
889738005274	GTP binding site [chemical binding]; other site
889738005275	Walker B motif; other site
889738005276	2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563
889738005277	Cellular and retroviral pepsin-like aspartate proteases; Region: pepsin_retropepsin_like; cl11403
889738005278	beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009
889738005279	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
889738005280	motif II; other site
889738005281	Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125
889738005282	Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523
889738005283	Siderophore biosynthesis protein domain; Region: AlcB; smart01006
889738005284	Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182
889738005285	PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703
889738005286	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
889738005287	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
889738005288	N-terminal plug; other site
889738005289	ligand-binding site [chemical binding]; other site
889738005290	Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480
889738005291	FhuF 2Fe-2S C-terminal domain; Region: FhuF_C; pfam11575
889738005292	Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264
889738005293	IucA / IucC family; Region: IucA_IucC; pfam04183
889738005294	Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276
889738005295	Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264
889738005296	IucA / IucC family; Region: IucA_IucC; pfam04183
889738005297	Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276
889738005298	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
889738005299	Major Facilitator Superfamily; Region: MFS_1; pfam07690
889738005300	putative substrate translocation pore; other site
889738005301	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
889738005302	Lysine/ornithine N-monooxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: IucD; COG3486
889738005303	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
889738005304	Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264
889738005305	IucA / IucC family; Region: IucA_IucC; pfam04183
889738005306	Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276
889738005307	This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002
889738005308	putative deacylase active site [active]
889738005309	Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661
889738005310	ABC1 family; Region: ABC1; cl17513
889738005311	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
889738005312	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
889738005313	active site
889738005314	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
889738005315	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
889738005316	active site
889738005317	Alkane hydroxylase is a bacterial, integral-membrane di-iron enzyme that shares a requirement for iron and oxygen for activity similar to that of the non-heme integral-membrane acyl coenzyme A (CoA) desaturases and acyl lipid desaturases. The alk genes...; Region: Alkane-hydroxylase; cd03512
889738005318	Fatty acid desaturase; Region: FA_desaturase; pfam00487
889738005319	Di-iron ligands [ion binding]; other site
889738005320	Cupin; Region: Cupin_6; pfam12852
889738005321	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
889738005322	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
889738005323	periplasmic folding chaperone; Provisional; Region: PRK10788
889738005324	SurA N-terminal domain; Region: SurA_N_3; cl07813
889738005325	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
889738005326	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
889738005327	IHF dimer interface [polypeptide binding]; other site
889738005328	IHF - DNA interface [nucleotide binding]; other site
889738005329	Poly(hydroxyalcanoate) granule associated protein (phasin); Region: Phasin; pfam05597
889738005330	Transcriptional regulator; Region: Rrf2; cl17282
889738005331	Rrf2 family protein; Region: rrf2_super; TIGR00738
889738005332	cysteine desulfurase; Provisional; Region: PRK14012
889738005333	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
889738005334	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
889738005335	catalytic residue [active]
889738005336	NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822
889738005337	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664
889738005338	trimerization site [polypeptide binding]; other site
889738005339	active site
889738005340	Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400
889738005341	co-chaperone HscB; Provisional; Region: hscB; PRK05014
889738005342	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
889738005343	HSP70 interaction site [polypeptide binding]; other site
889738005344	HSCB C-terminal oligomerisation domain; Region: HSCB_C; pfam07743
889738005345	chaperone protein HscA; Provisional; Region: hscA; PRK05183
889738005346	Nucleotide-binding domain of HscA and similar proteins; Region: HscA_like_NBD; cd10236
889738005347	nucleotide binding site [chemical binding]; other site
889738005348	putative NEF/HSP70 interaction site [polypeptide binding]; other site
889738005349	SBD interface [polypeptide binding]; other site
889738005350	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
889738005351	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
889738005352	catalytic loop [active]
889738005353	iron binding site [ion binding]; other site
889738005354	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
889738005355	cyclase homology domain; Region: CHD; cd07302
889738005356	nucleotidyl binding site; other site
889738005357	metal binding site [ion binding]; metal-binding site
889738005358	dimer interface [polypeptide binding]; other site
889738005359	HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228
889738005360	Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197
889738005361	CarD-like/TRCF domain; Region: CarD_TRCF; smart01058
889738005362	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
889738005363	ATP binding site [chemical binding]; other site
889738005364	putative Mg++ binding site [ion binding]; other site
889738005365	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
889738005366	nucleotide binding region [chemical binding]; other site
889738005367	ATP-binding site [chemical binding]; other site
889738005368	This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982
889738005369	Dyp-type peroxidase family; Region: Dyp_perox; cl01067
889738005370	GST_N family, 2 repeats of the N-terminal domain of soluble GSTs (2 GST_N) subfamily; composed of uncharacterized proteins. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a...; Region: GST_N_2GST_N; cd03041
889738005371	putative C-terminal domain interface [polypeptide binding]; other site
889738005372	putative GSH binding site (G-site) [chemical binding]; other site
889738005373	putative dimer interface [polypeptide binding]; other site
889738005374	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
889738005375	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
889738005376	ribonuclease activity regulator protein RraA; Provisional; Region: PRK09372
889738005377	CC3(TIP30)-like, atypical (a) SDRs; Region: CC3_like_SDR_a; cd05250
889738005378	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
889738005379	NAD binding site [chemical binding]; other site
889738005380	active site
889738005381	30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239
889738005382	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
889738005383	catalytic core [active]
889738005384	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
889738005385	CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638
889738005386	active site
889738005387	Uncharacterized ACR, COG2135; Region: DUF159; pfam02586
889738005388	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
889738005389	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
889738005390	Walker A/P-loop; other site
889738005391	ATP binding site [chemical binding]; other site
889738005392	Q-loop/lid; other site
889738005393	ABC transporter signature motif; other site
889738005394	Walker B; other site
889738005395	D-loop; other site
889738005396	H-loop/switch region; other site
889738005397	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
889738005398	Walker A/P-loop; other site
889738005399	ATP binding site [chemical binding]; other site
889738005400	Q-loop/lid; other site
889738005401	ABC transporter signature motif; other site
889738005402	Walker B; other site
889738005403	D-loop; other site
889738005404	H-loop/switch region; other site
889738005405	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
889738005406	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
889738005407	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
889738005408	dimer interface [polypeptide binding]; other site
889738005409	conserved gate region; other site
889738005410	putative PBP binding loops; other site
889738005411	ABC-ATPase subunit interface; other site
889738005412	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
889738005413	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
889738005414	dimer interface [polypeptide binding]; other site
889738005415	conserved gate region; other site
889738005416	putative PBP binding loops; other site
889738005417	ABC-ATPase subunit interface; other site
889738005418	Peptidase M3 Thimet oligopeptidase (TOP) also includes neurolysin; Region: M3A_TOP; cd06455
889738005419	Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339
889738005420	active site
889738005421	Zn binding site [ion binding]; other site
889738005422	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_18; cd08505
889738005423	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
889738005424	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_18; cd08505
889738005425	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
889738005426	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
889738005427	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
889738005428	N-terminal plug; other site
889738005429	ligand-binding site [chemical binding]; other site
889738005430	Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810
889738005431	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
889738005432	Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811
889738005433	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
889738005434	Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472
889738005435	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
889738005436	Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472
889738005437	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
889738005438	Coenzyme A binding pocket [chemical binding]; other site
889738005439	malate synthase G; Provisional; Region: PRK02999
889738005440	active site
889738005441	Predicted ATPase [General function prediction only]; Region: COG1485
889738005442	Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625
889738005443	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
889738005444	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
889738005445	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
889738005446	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
889738005447	Membrane protein of unknown function (DUF340); Region: DUF340; cl01028
889738005448	Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725
889738005449	active site
889738005450	dimer interface [polypeptide binding]; other site
889738005451	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
889738005452	IHF dimer interface [polypeptide binding]; other site
889738005453	IHF - DNA interface [nucleotide binding]; other site
889738005454	30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299
889738005455	S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687
889738005456	RNA binding site [nucleotide binding]; other site
889738005457	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
889738005458	RNA binding site [nucleotide binding]; other site
889738005459	S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688
889738005460	RNA binding site [nucleotide binding]; other site
889738005461	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
889738005462	RNA binding site [nucleotide binding]; other site
889738005463	S1_RPS1_repeat_ec5: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec5; cd05690
889738005464	RNA binding site [nucleotide binding]; other site
889738005465	S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec6; cd05691
889738005466	RNA binding site [nucleotide binding]; other site
889738005467	cytidylate kinase; Provisional; Region: cmk; PRK00023
889738005468	Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020
889738005469	CMP-binding site; other site
889738005470	The sites determining sugar specificity; other site
889738005471	Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821
889738005472	putative hydrophobic ligand binding site [chemical binding]; other site
889738005473	protein interface [polypeptide binding]; other site
889738005474	gate; other site
889738005475	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
889738005476	nucleoside/Zn binding site; other site
889738005477	dimer interface [polypeptide binding]; other site
889738005478	catalytic motif [active]
889738005479	3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617
889738005480	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
889738005481	substrate binding site [chemical binding]; other site
889738005482	oxyanion hole (OAH) forming residues; other site
889738005483	trimer interface [polypeptide binding]; other site
889738005484	2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766
889738005485	Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027
889738005486	ligand binding site [chemical binding]; other site
889738005487	active site
889738005488	UGI interface [polypeptide binding]; other site
889738005489	catalytic site [active]
889738005490	6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242
889738005491	Type II secretion system (T2SS), protein K; Region: T2SK; pfam03934
889738005492	Type II secretion system (T2SS), protein I; Region: T2SI; pfam02501
889738005493	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
889738005494	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
889738005495	Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099
889738005496	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
889738005497	active site
889738005498	PilZ domain; Region: PilZ; cl01260
889738005499	DNA polymerase III subunit delta'; Validated; Region: PRK05707
889738005500	3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450
889738005501	CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517
889738005502	Ligand binding site; other site
889738005503	oligomer interface; other site
889738005504	Tetraacyldisaccharide-1-P 4'-kinase [Cell envelope biogenesis, outer membrane]; Region: LpxK; COG1663
889738005505	Tetraacyldisaccharide-1-P 4'-kinase; Region: LpxK; pfam02606
889738005506	lipid A export permease/ATP-binding protein MsbA; Region: MsbA_lipidA; TIGR02203
889738005507	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
889738005508	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
889738005509	Walker A/P-loop; other site
889738005510	ATP binding site [chemical binding]; other site
889738005511	Q-loop/lid; other site
889738005512	ABC transporter signature motif; other site
889738005513	Walker B; other site
889738005514	D-loop; other site
889738005515	H-loop/switch region; other site
889738005516	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
889738005517	Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472
889738005518	Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811
889738005519	ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180
889738005520	ParB-like nuclease domain; Region: ParB; smart00470
889738005521	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
889738005522	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
889738005523	P-loop; other site
889738005524	Magnesium ion binding site [ion binding]; other site
889738005525	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
889738005526	Magnesium ion binding site [ion binding]; other site
889738005527	16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107
889738005528	rRNA small subunit methyltransferase G; Region: GidB; pfam02527
889738005529	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
889738005530	NTP_transferase_like_1 is a member of the nucleotidyl transferase family; Region: NTP_transferase_like_1; cd06422
889738005531	Substrate binding site; other site
889738005532	metal-binding site
889738005533	Predicted phosphotransferase related to Ser/Thr protein kinases [General function prediction only]; Region: COG3178
889738005534	Phosphotransferase enzyme family; Region: APH; pfam01636
889738005535	Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452
889738005536	OstA-like protein; Region: OstA; cl00844
889738005537	Organic solvent tolerance protein; Region: OstA_C; pfam04453
889738005538	peptidyl-prolyl cis-trans isomerase SurA; Provisional; Region: PRK10770
889738005539	SurA N-terminal domain; Region: SurA_N; pfam09312
889738005540	PPIC-type PPIASE domain; Region: Rotamase_2; cl08278
889738005541	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
889738005542	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947
889738005543	fructose-bisphosphate aldolase; Provisional; Region: PRK09197
889738005544	intersubunit interface [polypeptide binding]; other site
889738005545	active site
889738005546	zinc binding site [ion binding]; other site
889738005547	Na+ binding site [ion binding]; other site
889738005548	phosphoglycerate kinase; Provisional; Region: pgk; PRK00073
889738005549	Phosphoglycerate kinase; Region: PGK; pfam00162
889738005550	substrate binding site [chemical binding]; other site
889738005551	hinge regions; other site
889738005552	ADP binding site [chemical binding]; other site
889738005553	catalytic site [active]
889738005554	Uncharacterized protein conserved in bacteria (DUF2237); Region: DUF2237; pfam09996
889738005555	Maf-like protein; Region: Maf; pfam02545
889738005556	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
889738005557	active site
889738005558	dimer interface [polypeptide binding]; other site
889738005559	Cupin superfamily protein; Region: Cupin_4; pfam08007
889738005560	Cupin-like domain; Region: Cupin_8; pfam13621
889738005561	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
889738005562	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
889738005563	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
889738005564	dimerization interface [polypeptide binding]; other site
889738005565	putative DNA binding site [nucleotide binding]; other site
889738005566	putative Zn2+ binding site [ion binding]; other site
889738005567	serine/threonine transporter SstT; Provisional; Region: PRK13628
889738005568	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
889738005569	Protein of unknown function (DUF1275); Region: DUF1275; pfam06912
889738005570	Uncharacterized protein conserved in bacteria (DUF2058); Region: DUF2058; pfam09831
889738005571	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
889738005572	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
889738005573	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
889738005574	Walker A/P-loop; other site
889738005575	ATP binding site [chemical binding]; other site
889738005576	Q-loop/lid; other site
889738005577	ABC transporter signature motif; other site
889738005578	Walker B; other site
889738005579	D-loop; other site
889738005580	H-loop/switch region; other site
889738005581	YdeM is a Bacillus subtilis protein that belongs to a family of prokaryotic proteins of unkown function.  YdeM has sequence similarity to the hot-dog fold of (R)-specific enoyl-CoA hydratase.   Other enzymes with this fold include the peroxisomal...; Region: YdeM; cd03454
889738005582	putative active site [active]
889738005583	putative catalytic site [active]
889738005584	Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625
889738005585	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
889738005586	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
889738005587	Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848
889738005588	lipoyl attachment site [posttranslational modification]; other site
889738005589	NAD-dependent deacetylase; Provisional; Region: PRK00481
889738005590	SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412
889738005591	NAD+ binding site [chemical binding]; other site
889738005592	substrate binding site [chemical binding]; other site
889738005593	Zn binding site [ion binding]; other site
889738005594	Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475
889738005595	Na binding site [ion binding]; other site
889738005596	leucine-responsive transcriptional regulator; Provisional; Region: PRK11169
889738005597	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
889738005598	dimerization interface [polypeptide binding]; other site
889738005599	putative DNA binding site [nucleotide binding]; other site
889738005600	putative Zn2+ binding site [ion binding]; other site
889738005601	AsnC family; Region: AsnC_trans_reg; pfam01037
889738005602	bifunctional proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: PRK11905
889738005603	Proline dehydrogenase [Amino acid transport and metabolism]; Region: PutA; COG0506
889738005604	Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125
889738005605	Glutamate binding site [chemical binding]; other site
889738005606	NAD binding site [chemical binding]; other site
889738005607	catalytic residues [active]
889738005608	Uncharacterized protein family (UPF0157); Region: UPF0157; cl00987
889738005609	tRNA (uracil-5-)-methyltransferase; Validated; Region: PRK05031
889738005610	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
889738005611	S-adenosylmethionine binding site [chemical binding]; other site
889738005612	Predicted periplasmic protein [Function unknown]; Region: COG3698
889738005613	Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992
889738005614	Lecithin retinol acyltransferase; Region: LRAT; pfam04970
889738005615	Uncharacterized conserved protein [Function unknown]; Region: COG2353
889738005616	OsmC-like protein; Region: OsmC; pfam02566
889738005617	transketolase; Reviewed; Region: PRK12753
889738005618	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
889738005619	TPP-binding site [chemical binding]; other site
889738005620	dimer interface [polypeptide binding]; other site
889738005621	ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192
889738005622	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
889738005623	PYR/PP interface [polypeptide binding]; other site
889738005624	dimer interface [polypeptide binding]; other site
889738005625	TPP binding site [chemical binding]; other site
889738005626	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
889738005627	S-adenosylmethionine synthetase; Validated; Region: PRK05250
889738005628	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
889738005629	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
889738005630	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
889738005631	N2,N2-dimethylguanosine tRNA methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TRM1; COG1867
889738005632	FxsA cytoplasmic membrane protein; Region: FxsA; pfam04186
889738005633	Beta-lactamase class D [Defense mechanisms]; Region: COG2602
889738005634	Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247
889738005635	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
889738005636	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
889738005637	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
889738005638	non-specific DNA binding site [nucleotide binding]; other site
889738005639	salt bridge; other site
889738005640	sequence-specific DNA binding site [nucleotide binding]; other site
889738005641	Cupin domain; Region: Cupin_2; cl17218
889738005642	Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529
889738005643	active site
889738005644	putative DNA-binding cleft [nucleotide binding]; other site
889738005645	dimer interface [polypeptide binding]; other site
889738005646	putative carbohydrate kinase; Provisional; Region: PRK10565
889738005647	YjeF-related protein N-terminus; Region: YjeF_N; pfam03853
889738005648	B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171
889738005649	putative substrate binding site [chemical binding]; other site
889738005650	putative ATP binding site [chemical binding]; other site
889738005651	epoxyqueuosine reductase; Region: TIGR00276
889738005652	Domain of unknown function (DUF1730); Region: DUF1730; pfam08331
889738005653	biotin synthase; Provisional; Region: PRK15108
889738005654	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
889738005655	FeS/SAM binding site; other site
889738005656	Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876
889738005657	P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539
889738005658	P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121
889738005659	Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345
889738005660	Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753
889738005661	P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188
889738005662	PapC N-terminal domain; Region: PapC_N; pfam13954
889738005663	Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577
889738005664	PapC C-terminal domain; Region: PapC_C; pfam13953
889738005665	putative major fimbrial protein SthE; Provisional; Region: PRK15292
889738005666	P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539
889738005667	Transcriptional regulator [Transcription]; Region: LysR; COG0583
889738005668	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
889738005669	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
889738005670	dimerization interface [polypeptide binding]; other site
889738005671	EamA-like transporter family; Region: EamA; pfam00892
889738005672	Purine-cytosine permease and related proteins [Nucleotide transport and metabolism]; Region: CodB; COG1457
889738005673	Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133
889738005674	Na binding site [ion binding]; other site
889738005675	Predicted membrane protein [Function unknown]; Region: COG4125
889738005676	Bacterial Transmembrane Pair family; Region: BTP; pfam05232
889738005677	Bacterial Transmembrane Pair family; Region: BTP; pfam05232
889738005678	Transcriptional regulator [Transcription]; Region: LysR; COG0583
889738005679	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
889738005680	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
889738005681	dimerization interface [polypeptide binding]; other site
889738005682	Domain of unknown function (DUF4102); Region: DUF4102; pfam13356
889738005683	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
889738005684	active site
889738005685	catalytic residues [active]
889738005686	Int/Topo IB signature motif; other site
889738005687	DNA binding site [nucleotide binding]
889738005688	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
889738005689	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
889738005690	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown ABO13168; Region: LPLAT_ABO13168-like; cd07988
889738005691	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
889738005692	putative acyl-acceptor binding pocket; other site
889738005693	hypothetical protein; Validated; Region: PRK00110
889738005694	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
889738005695	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
889738005696	putative DNA binding site [nucleotide binding]; other site
889738005697	putative Zn2+ binding site [ion binding]; other site
889738005698	AsnC family; Region: AsnC_trans_reg; pfam01037
889738005699	DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563
889738005700	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
889738005701	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
889738005702	Walker A/P-loop; other site
889738005703	ATP binding site [chemical binding]; other site
889738005704	Q-loop/lid; other site
889738005705	ABC transporter signature motif; other site
889738005706	Walker B; other site
889738005707	D-loop; other site
889738005708	H-loop/switch region; other site
889738005709	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
889738005710	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
889738005711	dimer interface [polypeptide binding]; other site
889738005712	conserved gate region; other site
889738005713	putative PBP binding loops; other site
889738005714	ABC-ATPase subunit interface; other site
889738005715	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
889738005716	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
889738005717	dimer interface [polypeptide binding]; other site
889738005718	conserved gate region; other site
889738005719	putative PBP binding loops; other site
889738005720	ABC-ATPase subunit interface; other site
889738005721	glutamate and aspartate transporter subunit; Provisional; Region: PRK10797
889738005722	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
889738005723	substrate binding pocket [chemical binding]; other site
889738005724	membrane-bound complex binding site; other site
889738005725	hinge residues; other site
889738005726	Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of  glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570
889738005727	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
889738005728	C-terminal domain interface [polypeptide binding]; other site
889738005729	GSH binding site (G-site) [chemical binding]; other site
889738005730	dimer interface [polypeptide binding]; other site
889738005731	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776
889738005732	N-terminal domain interface [polypeptide binding]; other site
889738005733	sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022
889738005734	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
889738005735	active site
889738005736	sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022
889738005737	Dibenzothiophene (DBT) desulfurization enzyme C; Region: DszC; cd01163
889738005738	Flavin binding site [chemical binding]; other site
889738005739	FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860
889738005740	nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095
889738005741	active site
889738005742	non-prolyl cis peptide bond; other site
889738005743	NLPA lipoprotein; Region: Lipoprotein_9; pfam03180
889738005744	NLPA lipoprotein; Region: Lipoprotein_9; pfam03180
889738005745	DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153
889738005746	ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258
889738005747	Walker A/P-loop; other site
889738005748	ATP binding site [chemical binding]; other site
889738005749	Q-loop/lid; other site
889738005750	ABC transporter signature motif; other site
889738005751	Walker B; other site
889738005752	D-loop; other site
889738005753	H-loop/switch region; other site
889738005754	This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930
889738005755	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
889738005756	dimer interface [polypeptide binding]; other site
889738005757	conserved gate region; other site
889738005758	ABC-ATPase subunit interface; other site
889738005759	GTP-binding protein YchF; Reviewed; Region: PRK09601
889738005760	YchF GTPase; Region: YchF; cd01900
889738005761	G1 box; other site
889738005762	GTP/Mg2+ binding site [chemical binding]; other site
889738005763	Switch I region; other site
889738005764	G2 box; other site
889738005765	Switch II region; other site
889738005766	G3 box; other site
889738005767	G4 box; other site
889738005768	G5 box; other site
889738005769	TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867
889738005770	Predicted membrane protein [Function unknown]; Region: COG4539
889738005771	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
889738005772	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
889738005773	ligand binding site [chemical binding]; other site
889738005774	flexible hinge region; other site
889738005775	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
889738005776	putative switch regulator; other site
889738005777	non-specific DNA interactions [nucleotide binding]; other site
889738005778	DNA binding site [nucleotide binding]
889738005779	sequence specific DNA binding site [nucleotide binding]; other site
889738005780	putative cAMP binding site [chemical binding]; other site
889738005781	AzlC protein; Region: AzlC; cl00570
889738005782	putative L-valine exporter; Provisional; Region: PRK10408
889738005783	5-carboxymethyl-2-hydroxymuconate isomerase (CHMI) is a trimeric enzyme catalyzing the isomerization of the unsaturated ketone 5-(carboxymethyl)-2-hydroxymuconate to 5-(carboxymethyl)-2-oxo-3-hexene-1,6-dionate. This is one step in the...; Region: CHMI; cl01268
889738005784	trimer interface [polypeptide binding]; other site
889738005785	putative substrate binding pocket [chemical binding]; other site
889738005786	4-Oxalocrotonate Tautomerase:  Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235
889738005787	active site 1 [active]
889738005788	dimer interface [polypeptide binding]; other site
889738005789	hexamer interface [polypeptide binding]; other site
889738005790	active site 2 [active]
889738005791	phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288
889738005792	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
889738005793	ATP-grasp domain; Region: ATP-grasp; pfam02222
889738005794	PII uridylyl-transferase; Provisional; Region: glnD; PRK00275
889738005795	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
889738005796	metal binding triad; other site
889738005797	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
889738005798	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
889738005799	Zn2+ binding site [ion binding]; other site
889738005800	Mg2+ binding site [ion binding]; other site
889738005801	ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900
889738005802	C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899
889738005803	succinyldiaminopimelate transaminase; Provisional; Region: PRK09147
889738005804	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
889738005805	pyridoxal 5'-phosphate binding site [chemical binding]; other site
889738005806	homodimer interface [polypeptide binding]; other site
889738005807	catalytic residue [active]
889738005808	LysE type translocator; Region: LysE; cl00565
889738005809	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
889738005810	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
889738005811	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
889738005812	Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340
889738005813	catalytic residues [active]
889738005814	dimer interface [polypeptide binding]; other site
889738005815	methionine sulfoxide reductase B; Provisional; Region: PRK00222
889738005816	SelR domain; Region: SelR; pfam01641
889738005817	aminotransferase AlaT; Validated; Region: PRK09265
889738005818	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
889738005819	pyridoxal 5'-phosphate binding site [chemical binding]; other site
889738005820	homodimer interface [polypeptide binding]; other site
889738005821	catalytic residue [active]
889738005822	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
889738005823	Sodium:dicarboxylate symporter family; Region: SDF; cl00573
889738005824	Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964
889738005825	active site
889738005826	homodimer interface [polypeptide binding]; other site
889738005827	homotetramer interface [polypeptide binding]; other site
889738005828	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433
889738005829	DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673
889738005830	putative active site [active]
889738005831	putative PHP Thumb interface [polypeptide binding]; other site
889738005832	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
889738005833	generic binding surface I; other site
889738005834	generic binding surface II; other site
889738005835	rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565
889738005836	SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307
889738005837	serine O-acetyltransferase; Region: cysE; TIGR01172
889738005838	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
889738005839	trimer interface [polypeptide binding]; other site
889738005840	active site
889738005841	substrate binding site [chemical binding]; other site
889738005842	CoA binding site [chemical binding]; other site
889738005843	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
889738005844	TPR motif; other site
889738005845	binding surface
889738005846	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
889738005847	alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317
889738005848	Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974
889738005849	catalytic residue [active]
889738005850	TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026
889738005851	catalytic residues [active]
889738005852	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
889738005853	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
889738005854	Chromate transporter; Region: Chromate_transp; pfam02417
889738005855	Chromate transporter; Region: Chromate_transp; pfam02417
889738005856	Transcriptional regulator [Transcription]; Region: LysR; COG0583
889738005857	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
889738005858	The C-terminal substrate binding domain of LysR-type transcrptional regulator BudR, which is responsible for activation of the expression of the butanediol operon genes; contains the type 2 periplasmic binding fold; Region: PBP2_BudR; cd08451
889738005859	putative dimerization interface [polypeptide binding]; other site
889738005860	putative substrate binding pocket [chemical binding]; other site
889738005861	Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798
889738005862	arsenical-resistance protein; Region: acr3; TIGR00832
889738005863	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
889738005864	dimerization interface [polypeptide binding]; other site
889738005865	putative DNA binding site [nucleotide binding]; other site
889738005866	putative Zn2+ binding site [ion binding]; other site
889738005867	Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034
889738005868	ArsC family; Region: ArsC; pfam03960
889738005869	catalytic residues [active]
889738005870	Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574
889738005871	YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300
889738005872	active site
889738005873	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
889738005874	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
889738005875	YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012
889738005876	Isochorismatase family; Region: Isochorismatase; pfam00857
889738005877	catalytic triad [active]
889738005878	dimer interface [polypeptide binding]; other site
889738005879	conserved cis-peptide bond; other site
889738005880	Transcriptional regulator [Transcription]; Region: LysR; COG0583
889738005881	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
889738005882	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
889738005883	putative effector binding pocket; other site
889738005884	dimerization interface [polypeptide binding]; other site
889738005885	Transcriptional regulators [Transcription]; Region: GntR; COG1802
889738005886	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
889738005887	DNA-binding site [nucleotide binding]; DNA binding site
889738005888	FCD domain; Region: FCD; pfam07729
889738005889	uncharacterized nucleobase-cation-symport-1 (NCS1) transporter subfamily; solute-binding domain; Region: SLC-NCS1sbd_u1; cd11555
889738005890	Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133
889738005891	Na binding site [ion binding]; other site
889738005892	putative substrate binding site [chemical binding]; other site
889738005893	Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518
889738005894	taurine dioxygenase; Reviewed; Region: tauD; PRK09553
889738005895	Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175
889738005896	active site
889738005897	iron coordination sites [ion binding]; other site
889738005898	substrate binding pocket [chemical binding]; other site
889738005899	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
889738005900	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
889738005901	dimer interface [polypeptide binding]; other site
889738005902	conserved gate region; other site
889738005903	putative PBP binding loops; other site
889738005904	ABC-ATPase subunit interface; other site
889738005905	taurine transporter ATP-binding subunit; Provisional; Region: tauB; PRK11248
889738005906	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
889738005907	Walker A/P-loop; other site
889738005908	ATP binding site [chemical binding]; other site
889738005909	Q-loop/lid; other site
889738005910	ABC transporter signature motif; other site
889738005911	Walker B; other site
889738005912	D-loop; other site
889738005913	H-loop/switch region; other site
889738005914	taurine ABC transporter, periplasmic binding protein; Region: taurine_ABC_bnd; TIGR01729
889738005915	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
889738005916	substrate binding pocket [chemical binding]; other site
889738005917	membrane-bound complex binding site; other site
889738005918	hinge residues; other site
889738005919	Sugar (and other) transporter; Region: Sugar_tr; pfam00083
889738005920	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
889738005921	putative substrate translocation pore; other site
889738005922	FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860
889738005923	nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095
889738005924	active site
889738005925	non-prolyl cis peptide bond; other site
889738005926	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
889738005927	sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022
889738005928	active site
889738005929	Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654
889738005930	Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322
889738005931	cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219
889738005932	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
889738005933	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
889738005934	DNA-binding site [nucleotide binding]; DNA binding site
889738005935	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
889738005936	pyridoxal 5'-phosphate binding site [chemical binding]; other site
889738005937	homodimer interface [polypeptide binding]; other site
889738005938	catalytic residue [active]
889738005939	Transcriptional regulator [Transcription]; Region: LysR; COG0583
889738005940	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
889738005941	The C-terminal substrate-binding domian of LysR-type transcriptional regulator MdcR, which involved in the malonate catabolism contains the type 2 periplasmic binding fold; Region: PBP2_MdcR; cd08416
889738005942	putative dimerization interface [polypeptide binding]; other site
889738005943	malonate transporter, MadM subunit; Region: malonate_madM; TIGR00808
889738005944	Malonate transporter MadL subunit; Region: MadL; cl04273
889738005945	malonate decarboxylase, epsilon subunit; Region: malonate_mdcH; TIGR03131
889738005946	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
889738005947	phosphoribosyl-dephospho-CoA transferase; Provisional; Region: PRK01293
889738005948	Phosphoribosyl-dephospho-CoA transferase MdcG; Region: MdcG; pfam10620
889738005949	malonate decarboxylase, gamma subunit; Region: malonate_gamma; TIGR03134
889738005950	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189
889738005951	malonate decarboxylase subunit delta; Provisional; Region: PRK01220
889738005952	triphosphoribosyl-dephospho-CoA synthase; Validated; Region: PRK01237
889738005953	malonate decarboxylase, alpha subunit; Region: mdcA; TIGR01110
889738005954	Major Facilitator Superfamily; Region: MFS_1; pfam07690
889738005955	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
889738005956	putative substrate translocation pore; other site
889738005957	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
889738005958	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
889738005959	Transcriptional regulator [Transcription]; Region: PaiB; COG2808
889738005960	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
889738005961	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
889738005962	DNA-binding site [nucleotide binding]; DNA binding site
889738005963	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
889738005964	pyridoxal 5'-phosphate binding site [chemical binding]; other site
889738005965	homodimer interface [polypeptide binding]; other site
889738005966	catalytic residue [active]
889738005967	Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346
889738005968	LrgA family; Region: LrgA; cl00608
889738005969	Transcriptional regulator [Transcription]; Region: LysR; COG0583
889738005970	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
889738005971	The C-terminal substrate binding domain of LysR-like transcriptional regulator CidR, contains the type 2 periplasmic binding fold; Region: PBP2_CidR; cd08438
889738005972	putative dimerization interface [polypeptide binding]; other site
889738005973	glutathione S-transferase; Provisional; Region: PRK15113
889738005974	Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of  glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570
889738005975	C-terminal domain interface [polypeptide binding]; other site
889738005976	GSH binding site (G-site) [chemical binding]; other site
889738005977	dimer interface [polypeptide binding]; other site
889738005978	C-terminal, alpha helical domain of an unknown subfamily 4 of Glutathione S-transferases; Region: GST_C_4; cd03195
889738005979	putative dimer interface [polypeptide binding]; other site
889738005980	N-terminal domain interface [polypeptide binding]; other site
889738005981	putative substrate binding pocket (H-site) [chemical binding]; other site
889738005982	putative S-transferase; Provisional; Region: PRK11752
889738005983	GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048
889738005984	C-terminal domain interface [polypeptide binding]; other site
889738005985	GSH binding site (G-site) [chemical binding]; other site
889738005986	dimer interface [polypeptide binding]; other site
889738005987	C-terminal, alpha helical domain of Escherichia coli Yghu Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YghU_like; cd10292
889738005988	dimer interface [polypeptide binding]; other site
889738005989	N-terminal domain interface [polypeptide binding]; other site
889738005990	active site
889738005991	Transcriptional regulator [Transcription]; Region: LysR; COG0583
889738005992	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
889738005993	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472
889738005994	putative effector binding pocket; other site
889738005995	putative dimerization interface [polypeptide binding]; other site
889738005996	short chain dehydrogenase; Provisional; Region: PRK12937
889738005997	tetrahydroxynaphthalene/trihydroxynaphthalene reductase-like, classical (c) SDRs; Region: THN_reductase-like_SDR_c; cd05362
889738005998	NADP binding site [chemical binding]; other site
889738005999	homodimer interface [polypeptide binding]; other site
889738006000	active site
889738006001	substrate binding site [chemical binding]; other site
889738006002	Member of the Rhodanese Homology Domain superfamily, subgroup 1. This CD includes the putative rhodanese-related sulfurtransferases of several uncharacterized proteins; Region: RHOD_1; cd01522
889738006003	active site residue [active]
889738006004	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
889738006005	trimer interface [polypeptide binding]; other site
889738006006	active site
889738006007	substrate binding site [chemical binding]; other site
889738006008	CoA binding site [chemical binding]; other site
889738006009	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
889738006010	Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453
889738006011	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
889738006012	catalytic residue [active]
889738006013	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
889738006014	Transcriptional regulator [Transcription]; Region: LysR; COG0583
889738006015	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
889738006016	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
889738006017	putative effector binding pocket; other site
889738006018	dimerization interface [polypeptide binding]; other site
889738006019	Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062
889738006020	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
889738006021	substrate binding pocket [chemical binding]; other site
889738006022	membrane-bound complex binding site; other site
889738006023	hinge residues; other site
889738006024	Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062
889738006025	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
889738006026	substrate binding pocket [chemical binding]; other site
889738006027	membrane-bound complex binding site; other site
889738006028	hinge residues; other site
889738006029	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
889738006030	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
889738006031	Walker A/P-loop; other site
889738006032	ATP binding site [chemical binding]; other site
889738006033	Q-loop/lid; other site
889738006034	ABC transporter signature motif; other site
889738006035	Walker B; other site
889738006036	D-loop; other site
889738006037	H-loop/switch region; other site
889738006038	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
889738006039	dimer interface [polypeptide binding]; other site
889738006040	conserved gate region; other site
889738006041	putative PBP binding loops; other site
889738006042	ABC-ATPase subunit interface; other site
889738006043	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
889738006044	dimer interface [polypeptide binding]; other site
889738006045	conserved gate region; other site
889738006046	putative PBP binding loops; other site
889738006047	ABC-ATPase subunit interface; other site
889738006048	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
889738006049	Coenzyme A binding pocket [chemical binding]; other site
889738006050	Response regulator receiver domain; Region: Response_reg; pfam00072
889738006051	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
889738006052	active site
889738006053	phosphorylation site [posttranslational modification]
889738006054	intermolecular recognition site; other site
889738006055	dimerization interface [polypeptide binding]; other site
889738006056	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
889738006057	DNA binding residues [nucleotide binding]
889738006058	dimerization interface [polypeptide binding]; other site
889738006059	Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456
889738006060	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
889738006061	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
889738006062	dimer interface [polypeptide binding]; other site
889738006063	phosphorylation site [posttranslational modification]
889738006064	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
889738006065	ATP binding site [chemical binding]; other site
889738006066	Mg2+ binding site [ion binding]; other site
889738006067	G-X-G motif; other site
889738006068	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
889738006069	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
889738006070	active site
889738006071	phosphorylation site [posttranslational modification]
889738006072	intermolecular recognition site; other site
889738006073	dimerization interface [polypeptide binding]; other site
889738006074	Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456
889738006075	Na binding site [ion binding]; other site
889738006076	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
889738006077	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
889738006078	putative DNA binding site [nucleotide binding]; other site
889738006079	putative Zn2+ binding site [ion binding]; other site
889738006080	AsnC family; Region: AsnC_trans_reg; pfam01037
889738006081	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
889738006082	SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974
889738006083	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
889738006084	Catalytic site [active]
889738006085	Stress-induced bacterial acidophilic repeat motif; Region: KGG; pfam10685
889738006086	short chain dehydrogenase; Provisional; Region: PRK06701
889738006087	classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355
889738006088	NAD binding site [chemical binding]; other site
889738006089	metal binding site [ion binding]; metal-binding site
889738006090	active site
889738006091	hydroperoxidase II; Provisional; Region: katE; PRK11249
889738006092	Clade 2 of the heme-binding enzyme catalase; Region: catalase_clade_2; cd08155
889738006093	tetramer interface [polypeptide binding]; other site
889738006094	heme binding pocket [chemical binding]; other site
889738006095	Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132
889738006096	domain interactions; other site
889738006097	Competence-damaged protein; Region: CinA; pfam02464
889738006098	The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia.  This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775
889738006099	Transcriptional regulator [Transcription]; Region: LysR; COG0583
889738006100	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
889738006101	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
889738006102	putative effector binding pocket; other site
889738006103	dimerization interface [polypeptide binding]; other site
889738006104	SGNH_hydrolase subfamily, similar to the putative arylesterase/acylhydrolase from the rumen anaerobe Prevotella bryantii XynE. The P. bryantii XynE gene is located in a xylanase gene cluster. SGNH hydrolases are a diverse family of lipases and esterases; Region: XynE_like; cd01830
889738006105	active site
889738006106	catalytic triad [active]
889738006107	oxyanion hole [active]
889738006108	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
889738006109	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
889738006110	S-adenosylmethionine binding site [chemical binding]; other site
889738006111	AMP-binding domain protein; Validated; Region: PRK08315
889738006112	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
889738006113	Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917
889738006114	acyl-activating enzyme (AAE) consensus motif; other site
889738006115	putative AMP binding site [chemical binding]; other site
889738006116	putative active site [active]
889738006117	putative CoA binding site [chemical binding]; other site
889738006118	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
889738006119	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
889738006120	isovaleryl-CoA dehydrogenase; Region: PLN02519
889738006121	Isovaleryl-CoA dehydrogenase; Region: IVD; cd01156
889738006122	substrate binding site [chemical binding]; other site
889738006123	FAD binding site [chemical binding]; other site
889738006124	catalytic base [active]
889738006125	3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820
889738006126	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
889738006127	enoyl-CoA hydratase; Provisional; Region: PRK05995
889738006128	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
889738006129	substrate binding site [chemical binding]; other site
889738006130	oxyanion hole (OAH) forming residues; other site
889738006131	trimer interface [polypeptide binding]; other site
889738006132	Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770
889738006133	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
889738006134	ATP-grasp domain; Region: ATP-grasp_4; cl17255
889738006135	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
889738006136	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
889738006137	carboxyltransferase (CT) interaction site; other site
889738006138	biotinylation site [posttranslational modification]; other site
889738006139	Isopropylmalate/homocitrate/citramalate synthases [Amino acid transport and metabolism]; Region: LeuA; COG0119
889738006140	3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938
889738006141	active site
889738006142	catalytic residues [active]
889738006143	metal binding site [ion binding]; metal-binding site
889738006144	Transcriptional regulator [Transcription]; Region: LysR; COG0583
889738006145	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
889738006146	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
889738006147	putative effector binding pocket; other site
889738006148	dimerization interface [polypeptide binding]; other site
889738006149	indolepyruvate ferredoxin oxidoreductase; Validated; Region: PRK09193
889738006150	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
889738006151	dimer interface [polypeptide binding]; other site
889738006152	PYR/PP interface [polypeptide binding]; other site
889738006153	TPP binding site [chemical binding]; other site
889738006154	substrate binding site [chemical binding]; other site
889738006155	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629
889738006156	TPP-binding site [chemical binding]; other site
889738006157	Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014
889738006158	Thioesterase-like superfamily; Region: 4HBT_3; pfam13622
889738006159	Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418
889738006160	acyl-CoA dehydrogenase; Provisional; Region: PTZ00456
889738006161	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
889738006162	active site
889738006163	Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806
889738006164	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
889738006165	CoenzymeA binding site [chemical binding]; other site
889738006166	subunit interaction site [polypeptide binding]; other site
889738006167	PHB binding site; other site
889738006168	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
889738006169	Major Facilitator Superfamily; Region: MFS_1; pfam07690
889738006170	putative substrate translocation pore; other site
889738006171	Maltoporin periplasmic N-terminal extension; Region: Sugarporin_N; pfam11471
889738006172	3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428
889738006173	3-oxoacid CoA-transferase, A subunit; Region: pcaI_scoA_fam; TIGR02429
889738006174	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
889738006175	benzoate transport; Region: 2A0115; TIGR00895
889738006176	putative substrate translocation pore; other site
889738006177	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
889738006178	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
889738006179	active site
889738006180	enoyl-CoA hydratase; Provisional; Region: PRK08138
889738006181	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
889738006182	substrate binding site [chemical binding]; other site
889738006183	oxyanion hole (OAH) forming residues; other site
889738006184	trimer interface [polypeptide binding]; other site
889738006185	3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826
889738006186	classical (c) SDRs; Region: SDR_c; cd05233
889738006187	NAD(P) binding site [chemical binding]; other site
889738006188	active site
889738006189	3-hydroxy-acyl-CoA dehydrogenase; Validated; Region: PRK08268
889738006190	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
889738006191	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
889738006192	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
889738006193	acetyl-CoA acetyltransferase; Provisional; Region: PRK08131
889738006194	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
889738006195	dimer interface [polypeptide binding]; other site
889738006196	active site
889738006197	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
889738006198	Transcriptional regulator [Transcription]; Region: IclR; COG1414
889738006199	Bacterial transcriptional regulator; Region: IclR; pfam01614
889738006200	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
889738006201	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
889738006202	putative substrate translocation pore; other site
889738006203	Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070
889738006204	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
889738006205	FMN binding site [chemical binding]; other site
889738006206	substrate binding site [chemical binding]; other site
889738006207	putative catalytic residue [active]
889738006208	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
889738006209	enoyl-CoA hydratase; Provisional; Region: PRK06688
889738006210	substrate binding site [chemical binding]; other site
889738006211	oxyanion hole (OAH) forming residues; other site
889738006212	trimer interface [polypeptide binding]; other site
889738006213	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
889738006214	Transcriptional regulator [Transcription]; Region: IclR; COG1414
889738006215	Bacterial transcriptional regulator; Region: IclR; pfam01614
889738006216	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
889738006217	CoA-transferase family III; Region: CoA_transf_3; pfam02515
889738006218	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
889738006219	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
889738006220	active site
889738006221	benzoate transport; Region: 2A0115; TIGR00895
889738006222	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
889738006223	putative substrate translocation pore; other site
889738006224	phosphonoacetaldehyde hydrolase; Provisional; Region: PRK13478
889738006225	2-aminoethylphosphonate--pyruvate transaminase; Provisional; Region: PRK13479
889738006226	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
889738006227	catalytic residue [active]
889738006228	FAD dependent oxidoreductase TIGR03364; Region: HpnW_proposed
889738006229	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
889738006230	putative 2-aminoethylphosphonate ABC transporter, permease protein; Region: PhnU2; TIGR03262
889738006231	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
889738006232	dimer interface [polypeptide binding]; other site
889738006233	conserved gate region; other site
889738006234	putative PBP binding loops; other site
889738006235	ABC-ATPase subunit interface; other site
889738006236	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
889738006237	dimer interface [polypeptide binding]; other site
889738006238	conserved gate region; other site
889738006239	putative PBP binding loops; other site
889738006240	ABC-ATPase subunit interface; other site
889738006241	putative 2-aminoethylphosphonate ABC transporter, ATP-binding protein; Region: PhnT2; TIGR03265
889738006242	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
889738006243	Walker A/P-loop; other site
889738006244	ATP binding site [chemical binding]; other site
889738006245	Q-loop/lid; other site
889738006246	ABC transporter signature motif; other site
889738006247	Walker B; other site
889738006248	D-loop; other site
889738006249	H-loop/switch region; other site
889738006250	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
889738006251	ABC-type thiamine transport system, periplasmic component [Coenzyme metabolism]; Region: TbpA; COG4143
889738006252	transcriptional regulator protein; Region: phnR; TIGR03337
889738006253	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
889738006254	DNA-binding site [nucleotide binding]; DNA binding site
889738006255	UTRA domain; Region: UTRA; pfam07702
889738006256	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
889738006257	4-hydroxybenzoate 3-monooxygenase; Validated; Region: PRK08243
889738006258	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
889738006259	beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Region: pcaR_pcaU; TIGR02431
889738006260	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
889738006261	Bacterial transcriptional regulator; Region: IclR; pfam01614
889738006262	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
889738006263	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
889738006264	Transcriptional regulator [Transcription]; Region: LysR; COG0583
889738006265	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
889738006266	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_6; cd08475
889738006267	putative effector binding pocket; other site
889738006268	putative dimerization interface [polypeptide binding]; other site
889738006269	Carboxymuconolactone decarboxylase family; Region: CMD; cl00460
889738006270	succinic semialdehyde dehydrogenase; Region: PLN02278
889738006271	Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103
889738006272	tetramerization interface [polypeptide binding]; other site
889738006273	NAD(P) binding site [chemical binding]; other site
889738006274	catalytic residues [active]
889738006275	Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456
889738006276	Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133
889738006277	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
889738006278	Uncharacterized Candidatus pelagibacter aldehyde dehydrogenase, DhaS-like; Region: ALDH_DhaS; cd07114
889738006279	NAD(P) binding site [chemical binding]; other site
889738006280	catalytic residues [active]
889738006281	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
889738006282	Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296
889738006283	Flavin reductase like domain; Region: Flavin_Reduct; smart00903
889738006284	Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303
889738006285	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
889738006286	Amino acid synthesis; Region: AA_synth; pfam06684
889738006287	Transcriptional regulators [Transcription]; Region: GntR; COG1802
889738006288	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
889738006289	DNA-binding site [nucleotide binding]; DNA binding site
889738006290	FCD domain; Region: FCD; cl11656
889738006291	Uncharacterized conserved protein [Function unknown]; Region: COG5470
889738006292	Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038
889738006293	Catalase-like heme-binding proteins similar to the uncharacterized srpA; Region: srpA_like; cd08153
889738006294	putative heme binding pocket [chemical binding]; other site
889738006295	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
889738006296	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
889738006297	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
889738006298	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
889738006299	putative active site [active]
889738006300	putative NTP binding site [chemical binding]; other site
889738006301	putative nucleic acid binding site [nucleotide binding]; other site
889738006302	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
889738006303	CoenzymeA binding site [chemical binding]; other site
889738006304	subunit interaction site [polypeptide binding]; other site
889738006305	PHB binding site; other site
889738006306	phenylacetic acid degradation protein PaaY; Region: PaaY; TIGR02287
889738006307	paaY-like: This group is composed by uncharacterized proteins with similarity to the protein product of the E. coli paaY gene, which is part of the paa gene cluster responsible for phenylacetic acid degradation. Proteins in this group are expected to...; Region: LbH_paaY_like; cd04745
889738006308	putative trimer interface [polypeptide binding]; other site
889738006309	putative metal binding site [ion binding]; other site
889738006310	PaaX-like protein; Region: PaaX; pfam07848
889738006311	phenylacetic acid degradation operon negative regulatory protein PaaX; Region: PaaX_trns_reg; TIGR02277
889738006312	PaaX-like protein C-terminal domain; Region: PaaX_C; pfam08223
889738006313	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
889738006314	phenylacetate-CoA ligase; Region: PA_CoA_ligase; TIGR02155
889738006315	acyl-activating enzyme (AAE) consensus motif; other site
889738006316	AMP binding site [chemical binding]; other site
889738006317	active site
889738006318	CoA binding site [chemical binding]; other site
889738006319	beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050
889738006320	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
889738006321	dimer interface [polypeptide binding]; other site
889738006322	active site
889738006323	3-hydroxy-acyl-CoA dehydrogenase; Validated; Region: PRK08268
889738006324	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
889738006325	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
889738006326	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
889738006327	enoyl-CoA hydratase; Provisional; Region: PRK08140
889738006328	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
889738006329	substrate binding site [chemical binding]; other site
889738006330	oxyanion hole (OAH) forming residues; other site
889738006331	trimer interface [polypeptide binding]; other site
889738006332	enoyl-CoA hydratase-isomerase; Provisional; Region: PRK09674
889738006333	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
889738006334	substrate binding site [chemical binding]; other site
889738006335	oxyanion hole (OAH) forming residues; other site
889738006336	trimer interface [polypeptide binding]; other site
889738006337	phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160
889738006338	NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214
889738006339	FAD binding pocket [chemical binding]; other site
889738006340	FAD binding motif [chemical binding]; other site
889738006341	phosphate binding motif [ion binding]; other site
889738006342	beta-alpha-beta structure motif; other site
889738006343	NAD(p) ribose binding residues [chemical binding]; other site
889738006344	NAD binding pocket [chemical binding]; other site
889738006345	NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site
889738006346	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
889738006347	catalytic loop [active]
889738006348	iron binding site [ion binding]; other site
889738006349	Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151
889738006350	phenylacetate-CoA oxygenase, PaaJ subunit; Region: PA_CoA_Oxy4; TIGR02159
889738006351	Phenylacetic acid catabolic protein; Region: PaaA_PaaC; pfam05138
889738006352	phenylacetate-CoA oxygenase subunit PaaB; Provisional; Region: paaB; PRK13781
889738006353	phenylacetate-CoA oxygenase subunit PaaA; Provisional; Region: paaA; PRK13778
889738006354	phenylacetate-CoA oxygenase, PaaG subunit; Region: PA_CoA_Oxy1; TIGR02156
889738006355	bifunctional aldehyde dehydrogenase/enoyl-CoA hydratase; Provisional; Region: PRK11563
889738006356	N-terminal domain of the monoamine oxidase C dehydratase; Region: ALDH_MaoC-N; cd07128
889738006357	substrate binding site [chemical binding]; other site
889738006358	dimer interface [polypeptide binding]; other site
889738006359	NADP binding site [chemical binding]; other site
889738006360	catalytic residues [active]
889738006361	MaoC_C  The C-terminal hot dog fold of the MaoC (monoamine oxidase C) dehydratase regulatory protein. Orthologs of MaoC include PaaZ [Escherichia coli] and PaaN [Pseudomonas putida], which are putative ring-opening enzymes involved in phenylacetic acid...; Region: MaoC_C; cd03452
889738006362	substrate binding site [chemical binding]; other site
889738006363	L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720
889738006364	Serine dehydratase beta chain; Region: SDH_beta; pfam03315
889738006365	Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313
889738006366	amino acid transporter; Region: 2A0306; TIGR00909
889738006367	NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012
889738006368	Alpha-Ketoglutaric Semialdehyde Dehydrogenase; Region: ALDH_KGSADH; cd07129
889738006369	dimer interface [polypeptide binding]; other site
889738006370	NADP binding site [chemical binding]; other site
889738006371	catalytic residues [active]
889738006372	metabolite-proton symporter; Region: 2A0106; TIGR00883
889738006373	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
889738006374	putative substrate translocation pore; other site
889738006375	PAS fold; Region: PAS_4; pfam08448
889738006376	Helix-turn-helix domain; Region: HTH_18; pfam12833
889738006377	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
889738006378	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992
889738006379	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510
889738006380	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
889738006381	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
889738006382	hydroxyproline-2-epimerase; Provisional; Region: PRK13970
889738006383	hydroxyproline-2-epimerase; Provisional; Region: PRK13971
889738006384	Transcriptional regulators [Transcription]; Region: GntR; COG1802
889738006385	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
889738006386	DNA-binding site [nucleotide binding]; DNA binding site
889738006387	FCD domain; Region: FCD; pfam07729
889738006388	EamA-like transporter family; Region: EamA; pfam00892
889738006389	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
889738006390	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
889738006391	Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408
889738006392	inhibitor site; inhibition site
889738006393	active site
889738006394	dimer interface [polypeptide binding]; other site
889738006395	catalytic residue [active]
889738006396	Putative hemolysin [General function prediction only]; Region: Hlx; COG3042
889738006397	Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139
889738006398	Domain of unknown function (DUF333); Region: DUF333; pfam03891
889738006399	Peptidase inhibitor I78 family; Region: Inhibitor_I78; pfam11720
889738006400	redox-sensitive transcriptional activator SoxR; Region: SoxR; TIGR01950
889738006401	Helix-Turn-Helix DNA binding domain of the SoxR transcription regulator; Region: HTH_SoxR; cd01110
889738006402	DNA binding residues [nucleotide binding]
889738006403	dimer interface [polypeptide binding]; other site
889738006404	[2Fe-2S] cluster binding site [ion binding]; other site
889738006405	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
889738006406	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1636
889738006407	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
889738006408	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
889738006409	Coenzyme A binding pocket [chemical binding]; other site
889738006410	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214
889738006411	Protein of unknown function (DUF1006); Region: DUF1006; pfam06224
889738006412	putative cyanate transporter; Provisional; Region: cynX; PRK09705
889738006413	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
889738006414	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
889738006415	nucleoside/Zn binding site; other site
889738006416	dimer interface [polypeptide binding]; other site
889738006417	catalytic motif [active]
889738006418	Ankyrin repeats (many copies); Region: Ank_4; pfam13637
889738006419	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
889738006420	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
889738006421	Ankyrin repeats (many copies); Region: Ank_4; pfam13637
889738006422	Transcriptional regulator [Transcription]; Region: LysR; COG0583
889738006423	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
889738006424	LysR substrate binding domain; Region: LysR_substrate; pfam03466
889738006425	dimerization interface [polypeptide binding]; other site
889738006426	D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557
889738006427	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_M15_4; pfam13539
889738006428	type IV / VI secretion system protein, DotU family; Region: IV_VI_DotU; TIGR03349
889738006429	type VI secretion protein, VC_A0114 family; Region: VI_chp_4; TIGR03353
889738006430	Bacterial protein of unknown function (DUF876); Region: DUF876; pfam05936
889738006431	type VI secretion-associated protein, ImpA family; Region: VI_chp_8; TIGR03363
889738006432	ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812
889738006433	type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345
889738006434	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
889738006435	Walker A motif; other site
889738006436	ATP binding site [chemical binding]; other site
889738006437	Walker B motif; other site
889738006438	arginine finger; other site
889738006439	JNK_SAPK-associated protein-1; Region: Jnk-SapK_ap_N; pfam09744
889738006440	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
889738006441	Walker A motif; other site
889738006442	ATP binding site [chemical binding]; other site
889738006443	Walker B motif; other site
889738006444	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
889738006445	PAAR motif; Region: PAAR_motif; pfam05488
889738006446	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
889738006447	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
889738006448	ligand binding site [chemical binding]; other site
889738006449	Uncharacterized protein conserved in bacteria (DUF2094); Region: DUF2094; cl01611
889738006450	Type VI protein secretion system component VasK [Intracellular trafficking, secretion, and    vesicular transport]; Region: IcmF; COG3523
889738006451	Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761
889738006452	Protein of unknown function (DUF1215); Region: DUF1215; pfam06744
889738006453	Protein of unknown function (DUF1305); Region: DUF1305; pfam06996
889738006454	Type VI protein secretion system component VasA [Intracellular trafficking, secretion, and    vesicular transport]; Region: COG3519
889738006455	Bacterial protein of unknown function (DUF879); Region: DUF879; cl15462
889738006456	type VI secretion system lysozyme-like protein; Region: VI_zyme; TIGR03357
889738006457	Protein of unknown function (DUF796); Region: DUF796; pfam05638
889738006458	Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and    vesicular transport]; Region: COG3517; cl05484
889738006459	Protein of unknown function (DUF877); Region: DUF877; pfam05943
889738006460	Protein of unknown function (DUF770); Region: DUF770; pfam05591
889738006461	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4460
889738006462	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
889738006463	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
889738006464	dimer interface [polypeptide binding]; other site
889738006465	conserved gate region; other site
889738006466	putative PBP binding loops; other site
889738006467	ABC-ATPase subunit interface; other site
889738006468	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
889738006469	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
889738006470	Walker A/P-loop; other site
889738006471	ATP binding site [chemical binding]; other site
889738006472	Q-loop/lid; other site
889738006473	ABC transporter signature motif; other site
889738006474	Walker B; other site
889738006475	D-loop; other site
889738006476	H-loop/switch region; other site
889738006477	ABC transporter periplasmic binding protein, urea carboxylase region; Region: ABC_peri_uca; TIGR03427
889738006478	allophanate hydrolase; Provisional; Region: PRK08186
889738006479	Amidase; Region: Amidase; cl11426
889738006480	nickel responsive regulator; Provisional; Region: PRK04460
889738006481	NikR C terminal nickel binding domain; Region: NikR_C; pfam08753
889738006482	Predicted transcriptional regulators [Transcription]; Region: COG1733
889738006483	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
889738006484	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
889738006485	urea carboxylase; Region: urea_carbox; TIGR02712
889738006486	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
889738006487	ATP-grasp domain; Region: ATP-grasp_4; cl17255
889738006488	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
889738006489	Allophanate hydrolase subunit 2; Region: AHS2; smart00797
889738006490	Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896
889738006491	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
889738006492	carboxyltransferase (CT) interaction site; other site
889738006493	biotinylation site [posttranslational modification]; other site
889738006494	urea carboxylase-associated protein 1; Region: urea_degr_1; TIGR03424
889738006495	Domain of unknown function (DUF1989); Region: DUF1989; pfam09347
889738006496	urea carboxylase-associated protein 1; Region: urea_degr_1; TIGR03424
889738006497	urea carboxylase-associated protein 2; Region: urea_degr_2; TIGR03425
889738006498	ABTJ_02429; ykkC-yxkD leader
889738006499	Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283
889738006500	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
889738006501	NAD binding site [chemical binding]; other site
889738006502	catalytic Zn binding site [ion binding]; other site
889738006503	structural Zn binding site [ion binding]; other site
889738006504	Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821
889738006505	putative hydrophobic ligand binding site [chemical binding]; other site
889738006506	protein interface [polypeptide binding]; other site
889738006507	gate; other site
889738006508	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
889738006509	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
889738006510	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
889738006511	Sel1-like repeats; Region: SEL1; smart00671
889738006512	Sel1-like repeats; Region: SEL1; smart00671
889738006513	Sel1-like repeats; Region: SEL1; smart00671
889738006514	Sel1-like repeats; Region: SEL1; smart00671
889738006515	Sel1-like repeats; Region: SEL1; smart00671
889738006516	Sel1-like repeats; Region: SEL1; smart00671
889738006517	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
889738006518	ClC sycA-like chloride channel proteins. This ClC family presents in bacteria, where it facilitates acid resistance in acidic soil. Mutation of this gene (sycA) in Rhizobium tropici CIAT899 causes serious deficiencies in nodule development, nodulation...; Region: ClC_sycA_like; cd03682
889738006519	putative Cl- selectivity filter; other site
889738006520	putative pore gating glutamate residue; other site
889738006521	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
889738006522	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
889738006523	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
889738006524	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
889738006525	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
889738006526	carboxyltransferase (CT) interaction site; other site
889738006527	biotinylation site [posttranslational modification]; other site
889738006528	potential frameshift: common BLAST hit: gi|385236997|ref|YP_005798336.1| allophanate hydrolase
889738006529	Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896
889738006530	Allophanate hydrolase subunit 1; Region: AHS1; pfam02682
889738006531	Allophanate hydrolase subunit 2; Region: AHS2; pfam02626
889738006532	Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896
889738006533	hypothetical protein; Provisional; Region: PRK05463
889738006534	LamB/YcsF family of  lactam utilization protein; Region: LamB_YcsF_like; cd10787
889738006535	putative active site [active]
889738006536	Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914
889738006537	transcriptional regulator, ArgP family; Region: argP; TIGR03298
889738006538	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
889738006539	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
889738006540	dimerization interface [polypeptide binding]; other site
889738006541	RHS Repeat; Region: RHS_repeat; pfam05593
889738006542	Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209
889738006543	RHS Repeat; Region: RHS_repeat; pfam05593
889738006544	RHS Repeat; Region: RHS_repeat; pfam05593
889738006545	RHS Repeat; Region: RHS_repeat; pfam05593
889738006546	RHS Repeat; Region: RHS_repeat; pfam05593
889738006547	RHS Repeat; Region: RHS_repeat; pfam05593
889738006548	RHS protein; Region: RHS; pfam03527
889738006549	RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696
889738006550	Uncharacterized protein conserved in bacteria [Function unknown]; Region: VgrG; COG3501
889738006551	Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954
889738006552	Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717
889738006553	Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296
889738006554	Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; pfam10106
889738006555	Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354
889738006556	Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419
889738006557	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
889738006558	motif II; other site
889738006559	Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508
889738006560	Coenzyme A binding pocket [chemical binding]; other site
889738006561	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
889738006562	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
889738006563	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
889738006564	Helix-Turn-Helix DNA binding domain of the transcription regulators NolA and AlbR; Region: HTH_NolA-AlbR; cd04788
889738006565	DNA binding residues [nucleotide binding]
889738006566	putative dimer interface [polypeptide binding]; other site
889738006567	TipAS antibiotic-recognition domain; Region: TipAS; pfam07739
889738006568	TipAS antibiotic-recognition domain; Region: TipAS; pfam07739
889738006569	Uncharacterized protein conserved in bacteria (DUF2147); Region: DUF2147; pfam09917
889738006570	benzoate transport; Region: 2A0115; TIGR00895
889738006571	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
889738006572	putative substrate translocation pore; other site
889738006573	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
889738006574	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
889738006575	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
889738006576	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
889738006577	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
889738006578	putative acyl-acceptor binding pocket; other site
889738006579	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
889738006580	Threonine/homoserine efflux transporter [Amino acid transport and metabolism]; Region: rhtA; COG5006
889738006581	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
889738006582	AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404
889738006583	AsnC family; Region: AsnC_trans_reg; pfam01037
889738006584	DNA mismatch repair protein MutS; Provisional; Region: PRK05399
889738006585	MutS domain I; Region: MutS_I; pfam01624
889738006586	MutS domain II; Region: MutS_II; pfam05188
889738006587	MutS domain III; Region: MutS_III; pfam05192
889738006588	MutS domain V; Region: MutS_V; pfam00488
889738006589	Walker A/P-loop; other site
889738006590	ATP binding site [chemical binding]; other site
889738006591	Q-loop/lid; other site
889738006592	ABC transporter signature motif; other site
889738006593	Walker B; other site
889738006594	D-loop; other site
889738006595	H-loop/switch region; other site
889738006596	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
889738006597	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
889738006598	Coenzyme A binding pocket [chemical binding]; other site
889738006599	Ferredoxin [Energy production and conversion]; Region: COG1146
889738006600	4Fe-4S binding domain; Region: Fer4; cl02805
889738006601	Domain of unknown function (DUF3470); Region: DUF3470; pfam11953
889738006602	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3108
889738006603	Predicted O-methyltransferase [General function prediction only]; Region: COG4122
889738006604	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
889738006605	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
889738006606	Ligand Binding Site [chemical binding]; other site
889738006607	Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110
889738006608	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
889738006609	putative trimer interface [polypeptide binding]; other site
889738006610	Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647
889738006611	trimer interface [polypeptide binding]; other site
889738006612	active site
889738006613	substrate binding site [chemical binding]; other site
889738006614	putative CoA binding site [chemical binding]; other site
889738006615	CoA binding site [chemical binding]; other site
889738006616	Uncharacterized conserved protein [Function unknown]; Region: COG1739
889738006617	Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205
889738006618	type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843
889738006619	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
889738006620	HlyD family secretion protein; Region: HlyD_3; pfam13437
889738006621	type I secretion system ATPase, LssB family; Region: type_I_sec_LssB; TIGR03375
889738006622	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
889738006623	ATP-binding cassette domain of bacteriocin exporters, subfamily C; Region: ABCC_bacteriocin_exporters; cd03245
889738006624	Walker A/P-loop; other site
889738006625	ATP binding site [chemical binding]; other site
889738006626	Q-loop/lid; other site
889738006627	ABC transporter signature motif; other site
889738006628	Walker B; other site
889738006629	D-loop; other site
889738006630	H-loop/switch region; other site
889738006631	type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844
889738006632	ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137
889738006633	ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218
889738006634	Walker A/P-loop; other site
889738006635	ATP binding site [chemical binding]; other site
889738006636	Q-loop/lid; other site
889738006637	ABC transporter signature motif; other site
889738006638	Walker B; other site
889738006639	D-loop; other site
889738006640	H-loop/switch region; other site
889738006641	lipopolysaccharide transport periplasmic protein LptA; Region: outer_YhbN_LptA; TIGR03002
889738006642	OstA-like protein; Region: OstA; pfam03968
889738006643	Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835
889738006644	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3117; cl01200
889738006645	HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662
889738006646	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
889738006647	active site
889738006648	motif I; other site
889738006649	motif II; other site
889738006650	D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892
889738006651	KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014
889738006652	putative active site [active]
889738006653	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein.  These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604
889738006654	cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260
889738006655	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
889738006656	active site
889738006657	HIGH motif; other site
889738006658	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
889738006659	KMSKS motif; other site
889738006660	Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963
889738006661	tRNA binding surface [nucleotide binding]; other site
889738006662	anticodon binding site; other site
889738006663	Domain of unknown function (DUF4142); Region: DUF4142; pfam13628
889738006664	Predicted transcriptional regulators [Transcription]; Region: COG1733
889738006665	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
889738006666	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
889738006667	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
889738006668	putative substrate translocation pore; other site
889738006669	Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072
889738006670	pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880
889738006671	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232
889738006672	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
889738006673	DNA-binding site [nucleotide binding]; DNA binding site
889738006674	RNA-binding motif; other site
889738006675	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
889738006676	Glycosyl hydrolase 108; Region: Glyco_hydro_108; pfam05838
889738006677	Predicted Peptidoglycan domain; Region: PG_binding_3; pfam09374
889738006678	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
889738006679	Predicted transcriptional regulator [Transcription]; Region: COG2932
889738006680	non-specific DNA binding site [nucleotide binding]; other site
889738006681	salt bridge; other site
889738006682	sequence-specific DNA binding site [nucleotide binding]; other site
889738006683	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
889738006684	Catalytic site [active]
889738006685	exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286
889738006686	ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489
889738006687	generic binding surface II; other site
889738006688	generic binding surface I; other site
889738006689	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
889738006690	Cysteine-rich 4 helical bundle widely conserved in bacteria; Region: DUF326; cd08026
889738006691	dimerization interface [polypeptide binding]; other site
889738006692	Glutathione-dependent formaldehyde-activating enzyme; Region: GFA; pfam04828
889738006693	Cu(I)-responsive transcriptional regulator; Region: CueR; TIGR02044
889738006694	Helix-Turn-Helix DNA binding domain of CueR-like transcription regulators; Region: HTH_CueR; cd01108
889738006695	DNA binding residues [nucleotide binding]
889738006696	dimer interface [polypeptide binding]; other site
889738006697	copper binding site [ion binding]; other site
889738006698	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
889738006699	metal-binding site [ion binding]
889738006700	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
889738006701	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
889738006702	metal-binding site [ion binding]
889738006703	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
889738006704	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
889738006705	motif II; other site
889738006706	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
889738006707	metal-binding site [ion binding]
889738006708	DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906
889738006709	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
889738006710	The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in benzoate catabolism; contains the type 2 periplasmic binding fold; Region: PBP2_BenM_CatM_CatR; cd08445
889738006711	dimerizarion interface [polypeptide binding]; other site
889738006712	CrgA pocket; other site
889738006713	substrate binding pocket [chemical binding]; other site
889738006714	benzoate 1,2-dioxygenase, large subunit; Region: benzo_1_2_benA; TIGR03229
889738006715	Rieske non-heme iron oxygenase (RO) family, 2-Halobenzoate 1,2-dioxygenase (HBDO) subfamily, N-terminal Rieske domain of the oxygenase alpha subunit; ROs comprise a large class of aromatic ring-hydroxylating dioxygenases that enable microorganisms to...; Region: Rieske_RO_Alpha_HBDO; cd03542
889738006716	C-terminal catalytic domain of the oxygenase alpha subunit of Pseudomonas resinovorans strain CA10 anthranilate 1,2-dioxygenase and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_AntDO-like; cd08879
889738006717	putative alpha subunit interface [polypeptide binding]; other site
889738006718	putative active site [active]
889738006719	putative substrate binding site [chemical binding]; other site
889738006720	Fe binding site [ion binding]; other site
889738006721	Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667
889738006722	inter-subunit interface; other site
889738006723	anthranilate dioxygenase reductase; Provisional; Region: antC; PRK11872
889738006724	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
889738006725	catalytic loop [active]
889738006726	iron binding site [ion binding]; other site
889738006727	Benzoate dioxygenase reductase (BenDO) FAD/NAD binding domain. Oxygenases oxidize hydrocarbons using dioxygen as the oxidant. As a Class I bacterial dioxygenases, benzoate dioxygenase like proteins combine an [2Fe-2S] cluster containing N-terminal...; Region: BenDO_FAD_NAD; cd06209
889738006728	FAD binding pocket [chemical binding]; other site
889738006729	FAD binding motif [chemical binding]; other site
889738006730	phosphate binding motif [ion binding]; other site
889738006731	beta-alpha-beta structure motif; other site
889738006732	NAD binding pocket [chemical binding]; other site
889738006733	1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate dehydrogenase; Provisional; Region: benD; PRK12823
889738006734	1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate dehydrogenase (DHB DH)-like, classical (c) SDR; Region: DHB_DH-like_SDR_c; cd08937
889738006735	putative NAD(P) binding site [chemical binding]; other site
889738006736	active site
889738006737	benzoate transporter; Region: benE; TIGR00843
889738006738	Benzoate membrane transport protein; Region: BenE; pfam03594
889738006739	benzoate transport; Region: 2A0115; TIGR00895
889738006740	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
889738006741	putative substrate translocation pore; other site
889738006742	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
889738006743	putative substrate translocation pore; other site
889738006744	outer membrane porin, OprD family; Region: OprD; pfam03573
889738006745	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK07515
889738006746	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
889738006747	dimer interface [polypeptide binding]; other site
889738006748	active site
889738006749	CoA binding pocket [chemical binding]; other site
889738006750	ATP-dependent helicase HrpA; Region: DEAH_box_HrpA; TIGR01967
889738006751	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
889738006752	ATP binding site [chemical binding]; other site
889738006753	putative Mg++ binding site [ion binding]; other site
889738006754	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
889738006755	nucleotide binding region [chemical binding]; other site
889738006756	ATP-binding site [chemical binding]; other site
889738006757	Helicase associated domain (HA2); Region: HA2; pfam04408
889738006758	Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717
889738006759	Domain of unknown function (DUF3418); Region: DUF3418; pfam11898
889738006760	peroxiredoxin; Region: AhpC; TIGR03137
889738006761	Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015
889738006762	dimer interface [polypeptide binding]; other site
889738006763	decamer (pentamer of dimers) interface [polypeptide binding]; other site
889738006764	catalytic triad [active]
889738006765	peroxidatic and resolving cysteines [active]
889738006766	KTSC domain; Region: KTSC; pfam13619
889738006767	Predicted O-methyltransferase [General function prediction only]; Region: COG4122
889738006768	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
889738006769	S-adenosylmethionine binding site [chemical binding]; other site
889738006770	Protein of unknown function (DUF1653); Region: DUF1653; pfam07866
889738006771	alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317
889738006772	Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974
889738006773	catalytic residue [active]
889738006774	TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026
889738006775	catalytic residues [active]
889738006776	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
889738006777	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
889738006778	glutathionine S-transferase; Provisional; Region: PRK10542
889738006779	GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057
889738006780	C-terminal domain interface [polypeptide binding]; other site
889738006781	GSH binding site (G-site) [chemical binding]; other site
889738006782	dimer interface [polypeptide binding]; other site
889738006783	C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188
889738006784	dimer interface [polypeptide binding]; other site
889738006785	N-terminal domain interface [polypeptide binding]; other site
889738006786	substrate binding pocket (H-site) [chemical binding]; other site
889738006787	Predicted extracellular nuclease [General function prediction only]; Region: COG2374
889738006788	YhcR_OBF_like: A subfamily of OB-fold domains similar to the OB folds of Bacillus subtilis YhcR. YhcR is a sugar-nonspecific nuclease, which is active in the presence of Ca2+ and Mn2+. It cleaves RNA endonucleolytically, producing 3'-monophosphate...; Region: YhcR_OBF_like; cd04486
889738006789	generic binding surface II; other site
889738006790	generic binding surface I; other site
889738006791	Mycoplasma pulmonis MnuA nuclease-like; Region: MnuA_DNase1-like; cd10283
889738006792	putative active site [active]
889738006793	putative catalytic site [active]
889738006794	putative Mg binding site IVb [ion binding]; other site
889738006795	putative phosphate binding site [ion binding]; other site
889738006796	putative DNA binding site [nucleotide binding]; other site
889738006797	putative Mg binding site IVa [ion binding]; other site
889738006798	tRNA (guanine-N(7)-)-methyltransferase; Reviewed; Region: trmB; PRK00121
889738006799	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
889738006800	GST_N family, unknown subfamily 2; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_2; cd03047
889738006801	putative C-terminal domain interface [polypeptide binding]; other site
889738006802	putative GSH binding site (G-site) [chemical binding]; other site
889738006803	putative dimer interface [polypeptide binding]; other site
889738006804	C-terminal, alpha helical domain of an unknown subfamily 2 of Glutathione S-transferases; Region: GST_C_2; cd03180
889738006805	putative N-terminal domain interface [polypeptide binding]; other site
889738006806	putative dimer interface [polypeptide binding]; other site
889738006807	putative substrate binding pocket (H-site) [chemical binding]; other site
889738006808	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807
889738006809	Domain of unknown function (DUF2520); Region: DUF2520; pfam10728
889738006810	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
889738006811	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
889738006812	ligand binding site [chemical binding]; other site
889738006813	dihydroorotase; Validated; Region: pyrC; PRK09357
889738006814	Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317
889738006815	active site
889738006816	aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856
889738006817	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
889738006818	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
889738006819	23S rRNA m(2)G2445 methyltransferase; Provisional; Region: rlmL; PRK11783
889738006820	THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715
889738006821	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
889738006822	DNA methylase; Region: N6_N4_Mtase; cl17433
889738006823	Competence-damaged protein; Region: CinA; pfam02464
889738006824	ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346
889738006825	Clp amino terminal domain; Region: Clp_N; pfam02861
889738006826	Clp amino terminal domain; Region: Clp_N; pfam02861
889738006827	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
889738006828	Walker A motif; other site
889738006829	ATP binding site [chemical binding]; other site
889738006830	Walker B motif; other site
889738006831	arginine finger; other site
889738006832	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
889738006833	Walker A motif; other site
889738006834	ATP binding site [chemical binding]; other site
889738006835	Walker B motif; other site
889738006836	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
889738006837	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
889738006838	Peptidase family M23; Region: Peptidase_M23; pfam01551
889738006839	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
889738006840	Coenzyme A binding pocket [chemical binding]; other site
889738006841	OsmC-like protein; Region: OsmC; cl00767
889738006842	DNA-binding transcriptional dual regulator Crp; Provisional; Region: PRK11753
889738006843	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
889738006844	ligand binding site [chemical binding]; other site
889738006845	flexible hinge region; other site
889738006846	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
889738006847	putative switch regulator; other site
889738006848	non-specific DNA interactions [nucleotide binding]; other site
889738006849	DNA binding site [nucleotide binding]
889738006850	sequence specific DNA binding site [nucleotide binding]; other site
889738006851	putative cAMP binding site [chemical binding]; other site
889738006852	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
889738006853	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
889738006854	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
889738006855	active site
889738006856	catalytic tetrad [active]
889738006857	Peptidase family M48; Region: Peptidase_M48; pfam01435
889738006858	Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788
889738006859	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
889738006860	Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108
889738006861	ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: PRK12421
889738006862	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
889738006863	dimer interface [polypeptide binding]; other site
889738006864	motif 1; other site
889738006865	active site
889738006866	motif 2; other site
889738006867	motif 3; other site
889738006868	Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057
889738006869	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846
889738006870	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
889738006871	alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252
889738006872	Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673
889738006873	motif 1; other site
889738006874	active site
889738006875	motif 2; other site
889738006876	motif 3; other site
889738006877	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
889738006878	DHHA1 domain; Region: DHHA1; pfam02272
889738006879	aspartate kinase; Reviewed; Region: PRK06635
889738006880	AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261
889738006881	putative nucleotide binding site [chemical binding]; other site
889738006882	putative catalytic residues [active]
889738006883	putative Mg ion binding site [ion binding]; other site
889738006884	putative aspartate binding site [chemical binding]; other site
889738006885	ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913
889738006886	putative allosteric regulatory site; other site
889738006887	ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936
889738006888	carbon storage regulator; Provisional; Region: PRK01712
889738006889	bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182
889738006890	RNA/DNA hybrid binding site [nucleotide binding]; other site
889738006891	active site
889738006892	Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038
889738006893	Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816
889738006894	Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320
889738006895	active site
889738006896	purine riboside binding site [chemical binding]; other site
889738006897	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
889738006898	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
889738006899	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
889738006900	classical (c) SDRs; Region: SDR_c; cd05233
889738006901	short chain dehydrogenase; Provisional; Region: PRK05650
889738006902	NAD(P) binding site [chemical binding]; other site
889738006903	active site
889738006904	Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118
889738006905	Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687
889738006906	Pirin-related protein [General function prediction only]; Region: COG1741
889738006907	Pirin; Region: Pirin; pfam02678
889738006908	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
889738006909	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
889738006910	Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118
889738006911	Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687
889738006912	classical (c) SDRs; Region: SDR_c; cd05233
889738006913	short chain dehydrogenase; Provisional; Region: PRK05650
889738006914	NAD(P) binding site [chemical binding]; other site
889738006915	active site
889738006916	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
889738006917	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
889738006918	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316
889738006919	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
889738006920	Integrase core domain; Region: rve; pfam00665
889738006921	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
889738006922	multiple promoter invertase; Provisional; Region: mpi; PRK13413
889738006923	catalytic residues [active]
889738006924	catalytic nucleophile [active]
889738006925	Presynaptic Site I dimer interface [polypeptide binding]; other site
889738006926	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
889738006927	Synaptic Flat tetramer interface [polypeptide binding]; other site
889738006928	Synaptic Site I dimer interface [polypeptide binding]; other site
889738006929	DNA binding site [nucleotide binding]
889738006930	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
889738006931	DNA-binding interface [nucleotide binding]; DNA binding site
889738006932	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
889738006933	Domain of unknown function (DUF3330); Region: DUF3330; pfam11809
889738006934	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
889738006935	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
889738006936	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
889738006937	Coenzyme A binding pocket [chemical binding]; other site
889738006938	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
889738006939	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
889738006940	Coenzyme A binding pocket [chemical binding]; other site
889738006941	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
889738006942	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
889738006943	Coenzyme A binding pocket [chemical binding]; other site
889738006944	aminoglycoside resistance protein; Provisional; Region: PRK13746
889738006945	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
889738006946	active site
889738006947	NTP binding site [chemical binding]; other site
889738006948	metal binding triad [ion binding]; metal-binding site
889738006949	antibiotic binding site [chemical binding]; other site
889738006950	Domain of unknown function (DUF4111); Region: DUF4111; pfam13427
889738006951	Small Multidrug Resistance protein; Region: Multi_Drug_Res; pfam00893
889738006952	DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
889738006953	dihydropteroate synthase; Region: DHPS; TIGR01496
889738006954	substrate binding pocket [chemical binding]; other site
889738006955	dimer interface [polypeptide binding]; other site
889738006956	inhibitor binding site; inhibition site
889738006957	DDE domain; Region: DDE_Tnp_IS240; pfam13610
889738006958	Integrase core domain; Region: rve; pfam00665
889738006959	multiple promoter invertase; Provisional; Region: mpi; PRK13413
889738006960	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
889738006961	catalytic residues [active]
889738006962	catalytic nucleophile [active]
889738006963	Presynaptic Site I dimer interface [polypeptide binding]; other site
889738006964	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
889738006965	Synaptic Flat tetramer interface [polypeptide binding]; other site
889738006966	Synaptic Site I dimer interface [polypeptide binding]; other site
889738006967	DNA binding site [nucleotide binding]
889738006968	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
889738006969	DNA-binding interface [nucleotide binding]; DNA binding site
889738006970	Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; pfam01526
889738006971	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316
889738006972	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
889738006973	Integrase core domain; Region: rve; pfam00665
889738006974	D-alanine/D-serine/glycine permease; Provisional; Region: PRK11049
889738006975	Arginine/ornithine N-succinyltransferase beta subunit [Amino acid transport and metabolism]; Region: AstA; COG3138
889738006976	Arginine N-succinyltransferase beta subunit; Region: AstA; cl11440
889738006977	bifunctional succinylornithine transaminase/acetylornithine transaminase; Provisional; Region: PRK12381
889738006978	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
889738006979	inhibitor-cofactor binding pocket; inhibition site
889738006980	pyridoxal 5'-phosphate binding site [chemical binding]; other site
889738006981	catalytic residue [active]
889738006982	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
889738006983	AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404
889738006984	AsnC family; Region: AsnC_trans_reg; pfam01037
889738006985	gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK13473
889738006986	Escherichia coli NAD+-dependent gamma-aminobutyraldehyde dehydrogenase YdcW-like; Region: ALDH_ABALDH-YdcW; cd07092
889738006987	tetrameric interface [polypeptide binding]; other site
889738006988	NAD binding site [chemical binding]; other site
889738006989	catalytic residues [active]
889738006990	substrate binding site [chemical binding]; other site
889738006991	SnoaL-like domain; Region: SnoaL_2; pfam12680
889738006992	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
889738006993	Transcriptional regulators [Transcription]; Region: FadR; COG2186
889738006994	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
889738006995	DNA-binding site [nucleotide binding]; DNA binding site
889738006996	FCD domain; Region: FCD; pfam07729
889738006997	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
889738006998	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
889738006999	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
889738007000	Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113
889738007001	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
889738007002	Sel1 repeat; Region: Sel1; cl02723
889738007003	Sel1-like repeats; Region: SEL1; smart00671
889738007004	Sel1-like repeats; Region: SEL1; smart00671
889738007005	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
889738007006	Sel1-like repeats; Region: SEL1; smart00671
889738007007	Sel1-like repeats; Region: SEL1; smart00671
889738007008	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
889738007009	Sel1-like repeats; Region: SEL1; smart00671
889738007010	Sel1-like repeats; Region: SEL1; smart00671
889738007011	Sel1-like repeats; Region: SEL1; smart00671
889738007012	Sel1-like repeats; Region: SEL1; smart00671
889738007013	Sel1-like repeats; Region: SEL1; smart00671
889738007014	RHS Repeat; Region: RHS_repeat; pfam05593
889738007015	Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209
889738007016	RHS Repeat; Region: RHS_repeat; pfam05593
889738007017	RHS Repeat; Region: RHS_repeat; pfam05593
889738007018	RHS Repeat; Region: RHS_repeat; pfam05593
889738007019	RHS Repeat; Region: RHS_repeat; cl11982
889738007020	RHS protein; Region: RHS; pfam03527
889738007021	RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696
889738007022	Uncharacterized protein conserved in bacteria [Function unknown]; Region: VgrG; COG3501
889738007023	Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954
889738007024	Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717
889738007025	Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296
889738007026	Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; pfam10106
889738007027	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
889738007028	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
889738007029	ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464
889738007030	NLPA lipoprotein; Region: Lipoprotein_9; pfam03180
889738007031	Bacterial protein of unknown function (DUF898); Region: DUF898; pfam05987
889738007032	Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501
889738007033	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
889738007034	2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli  is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930
889738007035	active site
889738007036	FMN binding site [chemical binding]; other site
889738007037	2,4-decadienoyl-CoA binding site; other site
889738007038	catalytic residue [active]
889738007039	4Fe-4S cluster binding site [ion binding]; other site
889738007040	Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446
889738007041	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
889738007042	argininosuccinate synthase; Provisional; Region: PRK13820
889738007043	Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate .  In...; Region: Argininosuccinate_Synthase; cd01999
889738007044	ANP binding site [chemical binding]; other site
889738007045	Substrate Binding Site II [chemical binding]; other site
889738007046	Substrate Binding Site I [chemical binding]; other site
889738007047	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
889738007048	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
889738007049	metal binding site [ion binding]; metal-binding site
889738007050	active site
889738007051	I-site; other site
889738007052	Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294
889738007053	active site
889738007054	substrate binding pocket [chemical binding]; other site
889738007055	dimer interface [polypeptide binding]; other site
889738007056	DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847
889738007057	DEDDh 3'-5' exonuclease domain of RNase T; Region: RNaseT; cd06134
889738007058	dimer interface [polypeptide binding]; other site
889738007059	catalytic site [active]
889738007060	putative active site [active]
889738007061	putative substrate binding site [chemical binding]; other site
889738007062	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
889738007063	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
889738007064	N-terminal plug; other site
889738007065	ligand-binding site [chemical binding]; other site
889738007066	Old yellow enzyme (OYE)-related FMN binding domain, group 2.  Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_2_FMN; cd04733
889738007067	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
889738007068	putative active site [active]
889738007069	putative FMN binding site [chemical binding]; other site
889738007070	putative substrate binding site [chemical binding]; other site
889738007071	putative catalytic residue [active]
889738007072	ABC-type uncharacterized transport system, duplicated ATPase component [General function prediction only]; Region: COG4172
889738007073	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
889738007074	Walker A/P-loop; other site
889738007075	ATP binding site [chemical binding]; other site
889738007076	Q-loop/lid; other site
889738007077	ABC transporter signature motif; other site
889738007078	Walker B; other site
889738007079	D-loop; other site
889738007080	H-loop/switch region; other site
889738007081	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
889738007082	Walker A/P-loop; other site
889738007083	ATP binding site [chemical binding]; other site
889738007084	Q-loop/lid; other site
889738007085	ABC transporter signature motif; other site
889738007086	Walker B; other site
889738007087	D-loop; other site
889738007088	H-loop/switch region; other site
889738007089	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
889738007090	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4239
889738007091	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
889738007092	dimer interface [polypeptide binding]; other site
889738007093	conserved gate region; other site
889738007094	putative PBP binding loops; other site
889738007095	ABC-ATPase subunit interface; other site
889738007096	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4174
889738007097	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
889738007098	dimer interface [polypeptide binding]; other site
889738007099	conserved gate region; other site
889738007100	ABC-ATPase subunit interface; other site
889738007101	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
889738007102	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497
889738007103	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709
889738007104	membrane-bound lytic murein transglycosylase D; Provisional; Region: mltD; PRK10783
889738007105	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
889738007106	N-acetyl-D-glucosamine binding site [chemical binding]; other site
889738007107	catalytic residue [active]
889738007108	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
889738007109	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
889738007110	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
889738007111	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
889738007112	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
889738007113	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
889738007114	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
889738007115	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
889738007116	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
889738007117	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
889738007118	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
889738007119	RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278
889738007120	RNA/DNA hybrid binding site [nucleotide binding]; other site
889738007121	active site
889738007122	DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406
889738007123	DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131
889738007124	active site
889738007125	catalytic site [active]
889738007126	substrate binding site [chemical binding]; other site
889738007127	NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296
889738007128	NADH pyrophosphatase; Reviewed; Region: nudC; PRK00241
889738007129	NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297
889738007130	NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429
889738007131	putative NADH binding site [chemical binding]; other site
889738007132	putative active site [active]
889738007133	nudix motif; other site
889738007134	putative metal binding site [ion binding]; other site
889738007135	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
889738007136	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
889738007137	substrate binding pocket [chemical binding]; other site
889738007138	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
889738007139	Predicted periplasmic or secreted lipoprotein [General function prediction only]; Region: OsmY; COG2823
889738007140	BON domain; Region: BON; pfam04972
889738007141	hypothetical protein; Provisional; Region: PRK14674
889738007142	Predicted methyltransferases [General function prediction only]; Region: COG0313
889738007143	Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648
889738007144	putative SAM binding site [chemical binding]; other site
889738007145	putative homodimer interface [polypeptide binding]; other site
889738007146	Menaquinone biosynthesis; Region: VitK2_biosynth; cl17475
889738007147	chromosome replication initiation inhibitor protein; Validated; Region: PRK03635
889738007148	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
889738007149	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
889738007150	dimerization interface [polypeptide binding]; other site
889738007151	Lysine efflux permease [General function prediction only]; Region: COG1279
889738007152	Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230
889738007153	Cd(II)/Pb(II)-responsive transcriptional regulator; Region: CadR-PbrR; TIGR02047
889738007154	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
889738007155	DNA binding residues [nucleotide binding]
889738007156	Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988
889738007157	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
889738007158	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
889738007159	Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988
889738007160	Aminopeptidase P, N-terminal domain; Region: AMP_N; pfam05195
889738007161	proline aminopeptidase P II; Provisional; Region: PRK10879
889738007162	Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087
889738007163	active site
889738007164	Uncharacterized protein family (UPF0149); Region: UPF0149; pfam03695
889738007165	Cell division protein ZapA; Region: ZapA; pfam05164
889738007166	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
889738007167	active site
889738007168	DNA binding site [nucleotide binding]
889738007169	Int/Topo IB signature motif; other site
889738007170	Fungal domain of unknown function (DUF1750); Region: SWI-SNF_Ssr4; pfam08549
889738007171	lysozyme_like domain.  This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222
889738007172	catalytic residue [active]
889738007173	K+ potassium transporter; Region: K_trans; cl15781
889738007174	Domain of unknown function (DUF1833); Region: DUF1833; pfam08875
889738007175	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
889738007176	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
889738007177	N-acetyl-D-glucosamine binding site [chemical binding]; other site
889738007178	catalytic residue [active]
889738007179	Protein of unknown function (DUF3168); Region: DUF3168; pfam11367
889738007180	Bacteriophage protein of unknown function (DUF646); Region: DUF646; pfam04883
889738007181	Phage head-tail joining protein; Region: Phage_H_T_join; pfam05521
889738007182	Head-Tail Connector Proteins gp6 and gp15, and similar proteins; Region: gp6_gp15_like; cl12049
889738007183	phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554
889738007184	Syntaxin N-terminus domain; syntaxins are nervous system-specific proteins implicated in the docking of synaptic vesicles with the presynaptic plasma membrane; they are a family of receptors for intracellular transport vesicles; each target membrane may...; Region: SynN; cl00143
889738007185	interdomain interaction site; other site
889738007186	Phage capsid family; Region: Phage_capsid; pfam05065
889738007187	Caudovirus prohead protease; Region: Peptidase_U35; pfam04586
889738007188	Phage-related protein [Function unknown]; Region: COG4695
889738007189	Phage portal protein; Region: Phage_portal; pfam04860
889738007190	Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626
889738007191	Terminase small subunit; Region: Terminase_2; cl01513
889738007192	NinB protein; Region: NinB; pfam05772
889738007193	Phage antitermination protein Q; Region: Phage_antitermQ; pfam06530
889738007194	RIO kinase family, catalytic domain. The RIO kinase catalytic domain family is part of a larger superfamily, that includes the catalytic domains of other kinases such as the typical serine/threonine/tyrosine protein kinases (PKs), aminoglycoside...; Region: RIO; cl17248
889738007195	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
889738007196	replicative DNA helicase; Region: DnaB; TIGR00665
889738007197	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
889738007198	Walker A motif; other site
889738007199	ATP binding site [chemical binding]; other site
889738007200	Walker B motif; other site
889738007201	DNA binding loops [nucleotide binding]
889738007202	Protein of unknown function (DUF1376); Region: DUF1376; cl01531
889738007203	Conserved phage C-terminus (Phg_2220_C); Region: Phg_2220_C; cl09752
889738007204	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
889738007205	non-specific DNA binding site [nucleotide binding]; other site
889738007206	SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974
889738007207	salt bridge; other site
889738007208	sequence-specific DNA binding site [nucleotide binding]; other site
889738007209	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
889738007210	Catalytic site [active]
889738007211	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cl17512
889738007212	Helix-turn-helix domain; Region: HTH_17; cl17695
889738007213	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
889738007214	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
889738007215	active site
889738007216	Int/Topo IB signature motif; other site
889738007217	DNA binding site [nucleotide binding]
889738007218	putative metal dependent hydrolase; Provisional; Region: PRK11598
889738007219	Domain of unknown function (DUF1705); Region: DUF1705; pfam08019
889738007220	Sulfatase; Region: Sulfatase; pfam00884
889738007221	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
889738007222	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
889738007223	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
889738007224	Glycosyl hydrolase 108; Region: Glyco_hydro_108; pfam05838
889738007225	Predicted Peptidoglycan domain; Region: PG_binding_3; pfam09374
889738007226	Domain of unknown function (DUF1833); Region: DUF1833; pfam08875
889738007227	Phage-related minor tail protein [Function unknown]; Region: COG5281
889738007228	tape measure domain; Region: tape_meas_nterm; TIGR02675
889738007229	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
889738007230	Peptidase family M23; Region: Peptidase_M23; pfam01551
889738007231	Predicted transcriptional regulator [Transcription]; Region: COG2944
889738007232	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
889738007233	non-specific DNA binding site [nucleotide binding]; other site
889738007234	salt bridge; other site
889738007235	sequence-specific DNA binding site [nucleotide binding]; other site
889738007236	Domain of unknown function (DUF4258); Region: DUF4258; pfam14076
889738007237	DNA-binding transcriptional activator MhpR; Provisional; Region: PRK09834
889738007238	Bacterial SH3 domain homologues; Region: SH3b; smart00287
889738007239	Bacteriophage related domain of unknown function; Region: DUF4128; pfam13554
889738007240	LEM-like domain of lamina-associated polypeptide 2 (LAP2) and similar proteins; Region: LEM_like; cd12935
889738007241	phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554
889738007242	Phage protein (N4 Gp49/phage Sf6 gene 66) family; Region: Phage_gp49_66; pfam13876
889738007243	Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452
889738007244	Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072
889738007245	Domain of unknown function (DUF4055); Region: DUF4055; pfam13264
889738007246	Phage terminase large subunit; Region: Terminase_3; cl12054
889738007247	Uncharacterized conserved protein (DUF2280); Region: DUF2280; pfam10045
889738007248	Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277
889738007249	putative active site [active]
889738007250	Bacteriophage replication protein O; Region: Phage_rep_O; cl04545
889738007251	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
889738007252	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
889738007253	non-specific DNA binding site [nucleotide binding]; other site
889738007254	salt bridge; other site
889738007255	sequence-specific DNA binding site [nucleotide binding]; other site
889738007256	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
889738007257	Catalytic site [active]
889738007258	AAA domain; Region: AAA_24; pfam13479
889738007259	phage nucleotide-binding protein; Region: phage_P_loop; TIGR01618
889738007260	Helix-turn-helix domain; Region: HTH_17; cl17695
889738007261	serine hydroxymethyltransferase; Reviewed; Region: PRK13034
889738007262	5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812
889738007263	5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727
889738007264	SmpA / OmlA family; Region: SmpA_OmlA; pfam04355
889738007265	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
889738007266	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
889738007267	ligand binding site [chemical binding]; other site
889738007268	Extended Signal Peptide of Type V secretion system; Region: ESPR; pfam13018
889738007269	YadA-like, left-handed beta-roll; Region: LbR_YadA-like; cd12820
889738007270	trimer interface [polypeptide binding]; other site
889738007271	YadA-like, left-handed beta-roll; Region: LbR_YadA-like; cd12820
889738007272	trimer interface [polypeptide binding]; other site
889738007273	Left-handed beta-roll, including virulence factors and various other proteins; Region: LbR-like; cl17507
889738007274	trimer interface [polypeptide binding]; other site
889738007275	YadA-like, left-handed beta-roll; Region: LbR_YadA-like; cd12820
889738007276	trimer interface [polypeptide binding]; other site
889738007277	YadA-like, left-handed beta-roll; Region: LbR_YadA-like; cd12820
889738007278	trimer interface [polypeptide binding]; other site
889738007279	YadA-like C-terminal region; Region: YadA; pfam03895
889738007280	ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466
889738007281	Found in ATP-dependent protease La (LON); Region: LON; smart00464
889738007282	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
889738007283	Walker A motif; other site
889738007284	ATP binding site [chemical binding]; other site
889738007285	Walker B motif; other site
889738007286	arginine finger; other site
889738007287	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
889738007288	rRNA large subunit methyltransferase; Provisional; Region: PRK00103
889738007289	The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363
889738007290	Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900
889738007291	putative active site [active]
889738007292	metal binding site [ion binding]; metal-binding site
889738007293	META domain; Region: META; pfam03724
889738007294	META domain; Region: META; pfam03724
889738007295	Domain of unknown function (DUF4377); Region: DUF4377; pfam14302
889738007296	glutamate dehydrogenase; Provisional; Region: PRK09414
889738007297	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
889738007298	NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313
889738007299	NAD(P) binding site [chemical binding]; other site
889738007300	ferredoxin; Provisional; Region: PRK08764
889738007301	Putative Fe-S cluster; Region: FeS; cl17515
889738007302	4Fe-4S binding domain; Region: Fer4; pfam00037
889738007303	Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177
889738007304	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
889738007305	minor groove reading motif; other site
889738007306	helix-hairpin-helix signature motif; other site
889738007307	substrate binding pocket [chemical binding]; other site
889738007308	active site
889738007309	Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576
889738007310	adenylate kinase; Reviewed; Region: adk; PRK00279
889738007311	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
889738007312	AMP-binding site [chemical binding]; other site
889738007313	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
889738007314	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399
889738007315	penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423
889738007316	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
889738007317	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
889738007318	N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742
889738007319	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
889738007320	S-adenosylmethionine binding site [chemical binding]; other site
889738007321	HupE / UreJ protein; Region: HupE_UreJ; pfam04955
889738007322	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
889738007323	Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830
889738007324	UreF; Region: UreF; pfam01730
889738007325	urease accessory protein UreE; Provisional; Region: ureE; PRK13261
889738007326	UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571
889738007327	dimer interface [polypeptide binding]; other site
889738007328	catalytic residues [active]
889738007329	urease subunit alpha; Reviewed; Region: ureC; PRK13207
889738007330	Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375
889738007331	subunit interactions [polypeptide binding]; other site
889738007332	active site
889738007333	flap region; other site
889738007334	Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407
889738007335	gamma-beta subunit interface [polypeptide binding]; other site
889738007336	alpha-beta subunit interface [polypeptide binding]; other site
889738007337	Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390
889738007338	alpha-gamma subunit interface [polypeptide binding]; other site
889738007339	beta-gamma subunit interface [polypeptide binding]; other site
889738007340	UreD urease accessory protein; Region: UreD; pfam01774
889738007341	Uncharacterized lipoprotein NlpE involved in copper resistance [Cell envelope biogenesis, outer membrane / Inorganic ion transport and metabolism]; Region: CutF; COG3015
889738007342	NlpE N-terminal domain; Region: NlpE; pfam04170
889738007343	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
889738007344	tetramer interface [polypeptide binding]; other site
889738007345	active site
889738007346	Mg2+/Mn2+ binding site [ion binding]; other site
889738007347	isocitrate lyase; Region: PLN02892
889738007348	Transcriptional regulator [Transcription]; Region: LysR; COG0583
889738007349	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
889738007350	The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417
889738007351	substrate binding pocket [chemical binding]; other site
889738007352	dimerization interface [polypeptide binding]; other site
889738007353	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
889738007354	Domain of unknown function DUF21; Region: DUF21; pfam01595
889738007355	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
889738007356	Transporter associated domain; Region: CorC_HlyC; smart01091
889738007357	H+/citrate symporter [Energy production and conversion]; Region: CitM; COG2851
889738007358	Citrate transporter; Region: CitMHS; pfam03600
889738007359	Uncharacterized protein conserved in bacteria (DUF2239); Region: DUF2239; pfam09998
889738007360	sulfate adenylyltransferase subunit 1; Provisional; Region: cysN; PRK05124
889738007361	CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166
889738007362	CysD dimerization site [polypeptide binding]; other site
889738007363	G1 box; other site
889738007364	putative GEF interaction site [polypeptide binding]; other site
889738007365	GTP/Mg2+ binding site [chemical binding]; other site
889738007366	Switch I region; other site
889738007367	G2 box; other site
889738007368	G3 box; other site
889738007369	Switch II region; other site
889738007370	G4 box; other site
889738007371	G5 box; other site
889738007372	CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695
889738007373	TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095
889738007374	sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039
889738007375	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
889738007376	Active Sites [active]
889738007377	Capsule assembly protein Wzi; Region: Caps_assemb_Wzi; pfam14052
889738007378	lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484
889738007379	LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322
889738007380	dimer interface [polypeptide binding]; other site
889738007381	putative anticodon binding site; other site
889738007382	Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775
889738007383	motif 1; other site
889738007384	active site
889738007385	motif 2; other site
889738007386	motif 3; other site
889738007387	Uncharacterized protein family (UPF0227); Region: UPF0227; cl14886
889738007388	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
889738007389	Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814
889738007390	putative hydrophobic ligand binding site [chemical binding]; other site
889738007391	Rubredoxin [Energy production and conversion]; Region: COG1773
889738007392	Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730
889738007393	iron binding site [ion binding]; other site
889738007394	NADH:flavorubredoxin oxidoreductase; Provisional; Region: PRK04965
889738007395	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
889738007396	3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427
889738007397	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
889738007398	DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151
889738007399	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
889738007400	The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411
889738007401	dimerization interface [polypeptide binding]; other site
889738007402	Sporulation related domain; Region: SPOR; cl10051
889738007403	polyphosphate kinase; Provisional; Region: PRK05443
889738007404	Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089
889738007405	Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503
889738007406	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
889738007407	putative active site [active]
889738007408	catalytic site [active]
889738007409	Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168
889738007410	putative active site [active]
889738007411	putative domain interface [polypeptide binding]; other site
889738007412	catalytic site [active]
889738007413	monofunctional biosynthetic peptidoglycan transglycosylase; Provisional; Region: mtgA; PRK00056
889738007414	Transglycosylase; Region: Transgly; cl17702
889738007415	Rhomboid family; Region: Rhomboid; pfam01694
889738007416	Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127
889738007417	FtsX-like permease family; Region: FtsX; pfam02687
889738007418	FtsX-like permease family; Region: FtsX; pfam02687
889738007419	Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG4181
889738007420	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
889738007421	Walker A/P-loop; other site
889738007422	ATP binding site [chemical binding]; other site
889738007423	Q-loop/lid; other site
889738007424	ABC transporter signature motif; other site
889738007425	Walker B; other site
889738007426	D-loop; other site
889738007427	H-loop/switch region; other site
889738007428	Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822
889738007429	active site
889738007430	catalytic triad [active]
889738007431	oxyanion hole [active]
889738007432	switch loop; other site
889738007433	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378
889738007434	active site clefts [active]
889738007435	zinc binding site [ion binding]; other site
889738007436	dimer interface [polypeptide binding]; other site
889738007437	Lipase.  Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883
889738007438	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
889738007439	nucleophilic elbow; other site
889738007440	catalytic triad; other site
889738007441	outer membrane receptor FepA; Provisional; Region: PRK13524
889738007442	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
889738007443	N-terminal plug; other site
889738007444	ligand-binding site [chemical binding]; other site
889738007445	Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316
889738007446	IscR-regulated protein YhgI; Region: YhgI_GntY; TIGR03341
889738007447	Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694
889738007448	Rhomboid family; Region: Rhomboid; cl11446
889738007449	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
889738007450	Sulfatase; Region: Sulfatase; pfam00884
889738007451	Uncharacterized conserved protein [Function unknown]; Region: COG1262
889738007452	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
889738007453	D-Serine dehydratase is a pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of L- or D-serine  to pyruvate and ammonia.  D-serine dehydratase serves as a detoxifying enzyme in most E. coli strains where D-serine is a competitive...; Region: D-Ser-dehyd; cd06447
889738007454	Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291
889738007455	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
889738007456	catalytic residue [active]
889738007457	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
889738007458	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
889738007459	B12-dependent methionine synthase; Provisional; Region: metH; PRK09490
889738007460	Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646
889738007461	MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH).  Cobalamin-dependent...; Region: MeTr; cd00740
889738007462	substrate binding pocket [chemical binding]; other site
889738007463	B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069
889738007464	B12 binding site [chemical binding]; other site
889738007465	cobalt ligand [ion binding]; other site
889738007466	Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965
889738007467	Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958
889738007468	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
889738007469	PYR/PP interface [polypeptide binding]; other site
889738007470	dimer interface [polypeptide binding]; other site
889738007471	TPP binding site [chemical binding]; other site
889738007472	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
889738007473	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
889738007474	TPP-binding site [chemical binding]; other site
889738007475	dimer interface [polypeptide binding]; other site
889738007476	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
889738007477	D-galactonate transporter; Region: 2A0114; TIGR00893
889738007478	putative substrate translocation pore; other site
889738007479	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
889738007480	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
889738007481	NAD(P) binding site [chemical binding]; other site
889738007482	active site
889738007483	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
889738007484	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
889738007485	The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432
889738007486	dimerization interface [polypeptide binding]; other site
889738007487	substrate binding pocket [chemical binding]; other site
889738007488	galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019
889738007489	active site
889738007490	catalytic residues [active]
889738007491	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
889738007492	putative substrate translocation pore; other site
889738007493	Major Facilitator Superfamily; Region: MFS_1; pfam07690
889738007494	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
889738007495	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
889738007496	glutaminase; Provisional; Region: PRK00971
889738007497	Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066
889738007498	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
889738007499	active site
889738007500	catalytic residues [active]
889738007501	metal binding site [ion binding]; metal-binding site
889738007502	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
889738007503	metabolite-proton symporter; Region: 2A0106; TIGR00883
889738007504	putative substrate translocation pore; other site
889738007505	hypothetical protein; Provisional; Region: PRK07064
889738007506	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
889738007507	PYR/PP interface [polypeptide binding]; other site
889738007508	dimer interface [polypeptide binding]; other site
889738007509	TPP binding site [chemical binding]; other site
889738007510	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
889738007511	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568
889738007512	TPP-binding site [chemical binding]; other site
889738007513	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
889738007514	Uncharacterized Candidatus pelagibacter aldehyde dehydrogenase, DhaS-like; Region: ALDH_DhaS; cd07114
889738007515	NAD(P) binding site [chemical binding]; other site
889738007516	catalytic residues [active]
889738007517	L-aspartate dehydrogenase; Provisional; Region: PRK13303
889738007518	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
889738007519	Domain of unknown function DUF108; Region: DUF108; pfam01958
889738007520	short chain dehydrogenase; Provisional; Region: PRK07062
889738007521	putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344
889738007522	putative NAD(P) binding site [chemical binding]; other site
889738007523	putative active site [active]
889738007524	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
889738007525	Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303
889738007526	Cupin domain; Region: Cupin_2; pfam07883
889738007527	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
889738007528	D-galactonate transporter; Region: 2A0114; TIGR00893
889738007529	putative substrate translocation pore; other site
889738007530	phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754
889738007531	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
889738007532	C-terminal domain of Burkholderia sp. NF100 MhqB and similar proteins; MhqB is a type I extradiol dioxygenase involved in the catabolism of methylhydroquinone, an intermediate in the degradation of fenitrothion; Region: MhqB_like_C; cd08360
889738007533	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
889738007534	putative active site [active]
889738007535	putative metal binding site [ion binding]; other site
889738007536	short chain dehydrogenase; Provisional; Region: PRK12939
889738007537	classical (c) SDRs; Region: SDR_c; cd05233
889738007538	NAD(P) binding site [chemical binding]; other site
889738007539	active site
889738007540	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
889738007541	Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469
889738007542	[2Fe-2S] cluster binding site [ion binding]; other site
889738007543	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
889738007544	hydrophobic ligand binding site; other site
889738007545	Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528
889738007546	[2Fe-2S] cluster binding site [ion binding]; other site
889738007547	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
889738007548	Transcriptional regulator [Transcription]; Region: IclR; COG1414
889738007549	Bacterial transcriptional regulator; Region: IclR; pfam01614
889738007550	Nicotinamide mononucleotide transporter; Region: NMN_transporter; pfam04973
889738007551	enoyl-CoA hydratase; Provisional; Region: PRK06563
889738007552	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
889738007553	substrate binding site [chemical binding]; other site
889738007554	oxyanion hole (OAH) forming residues; other site
889738007555	trimer interface [polypeptide binding]; other site
889738007556	PgaD-like protein; Region: PgaD; pfam13994
889738007557	N-glycosyltransferase; Provisional; Region: PRK11204
889738007558	CESA_like is  the cellulose synthase superfamily; Region: CESA_like; cd06423
889738007559	DXD motif; other site
889738007560	poly-beta-1,6-N-acetyl-D-glucosamine N-deacetylase PgaB; Region: deacetyl_PgaB; TIGR03938
889738007561	N-terminal putative catalytic polysaccharide deacetylase domain of bacterial poly-beta-1,6-N-acetyl-D-glucosamine N-deacetylase PgaB, and similar proteins; Region: CE4_PgaB_5s; cd10964
889738007562	putative active site [active]
889738007563	putative metal binding site [ion binding]; other site
889738007564	FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545
889738007565	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
889738007566	YaeQ protein; Region: YaeQ; pfam07152
889738007567	C4-dicarboxylate transporter DctA; Reviewed; Region: PRK13027
889738007568	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
889738007569	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
889738007570	CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492
889738007571	Brown fat-inducible thioesterase (BFIT).  Brain acyl-CoA hydrolase (BACH).  These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442
889738007572	Multiple antibiotic transporter [Intracellular trafficking and secretion]; Region: MarC; COG2095
889738007573	choline transport protein BetT; Provisional; Region: PRK09928
889738007574	BCCT family transporter; Region: BCCT; pfam02028
889738007575	transcriptional regulator BetI; Validated; Region: PRK00767
889738007576	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
889738007577	Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977
889738007578	betaine aldehyde dehydrogenase; Provisional; Region: PRK13252
889738007579	NAD+-dependent 4-trimethylaminobutyraldehyde dehydrogenase, ALDH family 9A1; Region: ALDH_F9_TMBADH; cd07090
889738007580	tetrameric interface [polypeptide binding]; other site
889738007581	NAD binding site [chemical binding]; other site
889738007582	catalytic residues [active]
889738007583	choline dehydrogenase; Validated; Region: PRK02106
889738007584	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
889738007585	malate:quinone oxidoreductase; Validated; Region: PRK05257
889738007586	malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320
889738007587	Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574
889738007588	Homocysteine/selenocysteine methylase (S-methylmethionine-dependent) [Amino acid transport and metabolism]; Region: MHT1; COG2040
889738007589	arginine-ornithine antiporter; Region: arg_ornith_anti; TIGR03810
889738007590	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
889738007591	PGAP1-like protein; Region: PGAP1; pfam07819
889738007592	Protein of unknown function (DUF1275); Region: DUF1275; pfam06912
889738007593	Transcriptional regulator [Transcription]; Region: LysR; COG0583
889738007594	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
889738007595	The C-teminal substrate binding domain of LysR-like nitrogen assimilation control (NAC) protein, contains the type 2 periplasmic binding fold; Region: PBP2_Nac; cd08433
889738007596	putative dimerization interface [polypeptide binding]; other site
889738007597	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
889738007598	Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408
889738007599	inhibitor site; inhibition site
889738007600	active site
889738007601	dimer interface [polypeptide binding]; other site
889738007602	catalytic residue [active]
889738007603	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
889738007604	benzoate transport; Region: 2A0115; TIGR00895
889738007605	putative substrate translocation pore; other site
889738007606	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
889738007607	outer membrane porin, OprD family; Region: OprD; pfam03573
889738007608	Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dam; COG0338
889738007609	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
889738007610	AAA domain; Region: AAA_21; pfam13304
889738007611	Walker A/P-loop; other site
889738007612	ATP binding site [chemical binding]; other site
889738007613	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
889738007614	Walker B; other site
889738007615	D-loop; other site
889738007616	H-loop/switch region; other site
889738007617	Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405
889738007618	Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019
889738007619	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
889738007620	Major Facilitator Superfamily; Region: MFS_1; pfam07690
889738007621	putative substrate translocation pore; other site
889738007622	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
889738007623	efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998
889738007624	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
889738007625	HlyD family secretion protein; Region: HlyD_3; pfam13437
889738007626	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
889738007627	CoenzymeA binding site [chemical binding]; other site
889738007628	subunit interaction site [polypeptide binding]; other site
889738007629	PHB binding site; other site
889738007630	Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823
889738007631	dimer interface [polypeptide binding]; other site
889738007632	allosteric magnesium binding site [ion binding]; other site
889738007633	active site
889738007634	aspartate-rich active site metal binding site; other site
889738007635	Schiff base residues; other site
889738007636	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
889738007637	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
889738007638	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
889738007639	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
889738007640	Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090
889738007641	NAD(P) binding site [chemical binding]; other site
889738007642	active site
889738007643	N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247
889738007644	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
889738007645	Organic hydroperoxide reductase [Secondary metabolites biosynthesis, transport and catabolism]; Region: osmC; COG1764
889738007646	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
889738007647	Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840
889738007648	active site
889738007649	metal binding site [ion binding]; metal-binding site
889738007650	DNA binding site [nucleotide binding]
889738007651	Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320
889738007652	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
889738007653	Walker A/P-loop; other site
889738007654	ATP binding site [chemical binding]; other site
889738007655	Q-loop/lid; other site
889738007656	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
889738007657	ABC transporter signature motif; other site
889738007658	Walker B; other site
889738007659	D-loop; other site
889738007660	H-loop/switch region; other site
889738007661	Pyridoxal 5-phosphate (PLP)-binding TIM barrel domain of Type III PLP-Dependent Enzymes, Yggs-like proteins; Region: PLPDE_III_Yggs_like; cd06824
889738007662	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
889738007663	catalytic residue [active]
889738007664	Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805
889738007665	Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131
889738007666	Walker A motif; other site
889738007667	ATP binding site [chemical binding]; other site
889738007668	Walker B motif; other site
889738007669	Tfp pilus assembly protein, ATPase PilU [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilU; COG5008
889738007670	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
889738007671	Walker A motif; other site
889738007672	ATP binding site [chemical binding]; other site
889738007673	Walker B motif; other site
889738007674	ferric uptake regulator; Provisional; Region: fur; PRK09462
889738007675	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
889738007676	metal binding site 2 [ion binding]; metal-binding site
889738007677	putative DNA binding helix; other site
889738007678	metal binding site 1 [ion binding]; metal-binding site
889738007679	dimer interface [polypeptide binding]; other site
889738007680	structural Zn2+ binding site [ion binding]; other site
889738007681	outer membrane biogenesis protein BamE; Provisional; Region: PRK11548
889738007682	SmpA / OmlA family; Region: SmpA_OmlA; pfam04355
889738007683	hypothetical protein; Validated; Region: PRK01777
889738007684	Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456
889738007685	Hemerythrin; Region: Hemerythrin; cd12107
889738007686	Fe binding site [ion binding]; other site
889738007687	Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121
889738007688	Glutamine amidotransferases class-II (Gn-AT)_YafJ-type.  YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea.  YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908
889738007689	putative dimer interface [polypeptide binding]; other site
889738007690	putative active site [active]
889738007691	Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; pfam13444
889738007692	AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250
889738007693	feedback inhibition sensing region; other site
889738007694	homohexameric interface [polypeptide binding]; other site
889738007695	nucleotide binding site [chemical binding]; other site
889738007696	N-acetyl-L-glutamate binding site [chemical binding]; other site
889738007697	Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109
889738007698	The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089
889738007699	active site
889738007700	substrate binding site [chemical binding]; other site
889738007701	metal binding site [ion binding]; metal-binding site
889738007702	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
889738007703	trimer interface [polypeptide binding]; other site
889738007704	active site
889738007705	ATP-dependent DNA helicase Rep; Region: rep; TIGR01074
889738007706	Part of AAA domain; Region: AAA_19; pfam13245
889738007707	Family description; Region: UvrD_C_2; pfam13538
889738007708	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
889738007709	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
889738007710	ligand binding site [chemical binding]; other site
889738007711	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
889738007712	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; Region: LPLAT_LCLAT1-like; cd07990
889738007713	putative acyl-acceptor binding pocket; other site
889738007714	Septum formation inhibitor [Cell division and chromosome partitioning]; Region: MinC; COG0850
889738007715	Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775
889738007716	Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894
889738007717	Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036
889738007718	Switch I; other site
889738007719	Switch II; other site
889738007720	Septum formation topological specificity factor MinE; Region: MinE; pfam03776
889738007721	threonine efflux system; Provisional; Region: PRK10229
889738007722	Domain of unknown function (DUF4117); Region: DUF4117; pfam13491
889738007723	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
889738007724	This domain directs oriented DNA translocation and forms a winged helix structure; Region: Ftsk_gamma; smart00843
889738007725	thioredoxin reductase; Provisional; Region: PRK10262
889738007726	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
889738007727	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
889738007728	leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301
889738007729	arginyl-tRNA-protein transferase; Provisional; Region: PRK01305
889738007730	Arginine-tRNA-protein transferase, N terminus; Region: ATE_N; pfam04376
889738007731	Arginine-tRNA-protein transferase, C terminus; Region: ATE_C; pfam04377
889738007732	ribosomal-protein-alanine N-acetyltransferase; Provisional; Region: rimI; PRK09491
889738007733	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
889738007734	Coenzyme A binding pocket [chemical binding]; other site
889738007735	Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687
889738007736	Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118
889738007737	Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687
889738007738	Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118
889738007739	elongation factor Tu; Reviewed; Region: PRK00049
889738007740	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
889738007741	G1 box; other site
889738007742	GEF interaction site [polypeptide binding]; other site
889738007743	GTP/Mg2+ binding site [chemical binding]; other site
889738007744	Switch I region; other site
889738007745	G2 box; other site
889738007746	G3 box; other site
889738007747	Switch II region; other site
889738007748	G4 box; other site
889738007749	G5 box; other site
889738007750	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
889738007751	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
889738007752	Antibiotic Binding Site [chemical binding]; other site
889738007753	elongation factor G; Reviewed; Region: PRK00007
889738007754	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
889738007755	G1 box; other site
889738007756	putative GEF interaction site [polypeptide binding]; other site
889738007757	GTP/Mg2+ binding site [chemical binding]; other site
889738007758	Switch I region; other site
889738007759	G2 box; other site
889738007760	G3 box; other site
889738007761	Switch II region; other site
889738007762	G4 box; other site
889738007763	G5 box; other site
889738007764	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
889738007765	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
889738007766	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
889738007767	30S ribosomal protein S7; Validated; Region: PRK05302
889738007768	S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368
889738007769	S17 interaction site [polypeptide binding]; other site
889738007770	S8 interaction site; other site
889738007771	16S rRNA interaction site [nucleotide binding]; other site
889738007772	streptomycin interaction site [chemical binding]; other site
889738007773	23S rRNA interaction site [nucleotide binding]; other site
889738007774	aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site
889738007775	EcsC protein family; Region: EcsC; pfam12787
889738007776	3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK07967
889738007777	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
889738007778	dimer interface [polypeptide binding]; other site
889738007779	active site
889738007780	Uncharacterized protein family (UPF0093); Region: UPF0093; pfam03653
889738007781	Pirin; Region: Pirin; pfam02678
889738007782	Pirin-related protein [General function prediction only]; Region: COG1741
889738007783	Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726
889738007784	NAD synthetase; Provisional; Region: PRK13981
889738007785	Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570
889738007786	multimer interface [polypeptide binding]; other site
889738007787	active site
889738007788	catalytic triad [active]
889738007789	protein interface 1 [polypeptide binding]; other site
889738007790	NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553
889738007791	homodimer interface [polypeptide binding]; other site
889738007792	NAD binding pocket [chemical binding]; other site
889738007793	ATP binding pocket [chemical binding]; other site
889738007794	Mg binding site [ion binding]; other site
889738007795	active-site loop [active]
889738007796	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
889738007797	Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal  ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185
889738007798	FMN-binding pocket [chemical binding]; other site
889738007799	flavin binding motif; other site
889738007800	phosphate binding motif [ion binding]; other site
889738007801	beta-alpha-beta structure motif; other site
889738007802	NAD binding pocket [chemical binding]; other site
889738007803	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
889738007804	catalytic loop [active]
889738007805	iron binding site [ion binding]; other site
889738007806	succinic semialdehyde dehydrogenase; Region: PLN02278
889738007807	Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103
889738007808	tetramerization interface [polypeptide binding]; other site
889738007809	NAD(P) binding site [chemical binding]; other site
889738007810	catalytic residues [active]
889738007811	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
889738007812	Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469
889738007813	[2Fe-2S] cluster binding site [ion binding]; other site
889738007814	C-terminal catalytic domain of the oxygenase alpha subunit of an uncharacterized subgroup of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C_2; cd08886
889738007815	putative alpha subunit interface [polypeptide binding]; other site
889738007816	putative active site [active]
889738007817	putative substrate binding site [chemical binding]; other site
889738007818	Fe binding site [ion binding]; other site
889738007819	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
889738007820	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
889738007821	substrate binding pocket [chemical binding]; other site
889738007822	putative transporter; Provisional; Region: PRK09950
889738007823	Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473
889738007824	tartrate dehydrogenase; Region: TTC; TIGR02089
889738007825	transcriptional activator TtdR; Provisional; Region: PRK09801
889738007826	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
889738007827	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_9; cd08479
889738007828	putative effector binding pocket; other site
889738007829	putative dimerization interface [polypeptide binding]; other site
889738007830	Phosphate-selective porin O and P; Region: Porin_O_P; pfam07396
889738007831	4Fe-4S dicluster domain; Region: Fer4_9; pfam13187
889738007832	phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168
889738007833	Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163
889738007834	active site
889738007835	(T/H)XGH motif; other site
889738007836	Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294
889738007837	SmpB-tmRNA interface; other site
889738007838	Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655
889738007839	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
889738007840	Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578
889738007841	Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496
889738007842	23S rRNA pseudouridine synthase D; Provisional; Region: rluD; PRK11180
889738007843	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
889738007844	RNA binding surface [nucleotide binding]; other site
889738007845	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
889738007846	active site
889738007847	Outer membrane lipoprotein; Region: YfiO; pfam13525
889738007848	DNA primase; Validated; Region: dnaG; PRK05667
889738007849	CHC2 zinc finger; Region: zf-CHC2; pfam01807
889738007850	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
889738007851	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
889738007852	active site
889738007853	metal binding site [ion binding]; metal-binding site
889738007854	interdomain interaction site; other site
889738007855	DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410
889738007856	glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045
889738007857	NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213
889738007858	tRNA; other site
889738007859	putative tRNA binding site [nucleotide binding]; other site
889738007860	putative NADP binding site [chemical binding]; other site
889738007861	Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745
889738007862	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
889738007863	binding surface
889738007864	TPR motif; other site
889738007865	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
889738007866	binding surface
889738007867	TPR motif; other site
889738007868	outer membrane lipoprotein LolB; Provisional; Region: lolB; PRK00022
889738007869	Outer membrane lipoprotein LolB; Region: LolB; pfam03550
889738007870	4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00343
889738007871	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
889738007872	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
889738007873	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259
889738007874	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
889738007875	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
889738007876	active site
889738007877	Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495
889738007878	5S rRNA interface [nucleotide binding]; other site
889738007879	CTC domain interface [polypeptide binding]; other site
889738007880	L16 interface [polypeptide binding]; other site
889738007881	Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
889738007882	putative active site [active]
889738007883	catalytic residue [active]
889738007884	Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent  decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919
889738007885	tetramerization interface [polypeptide binding]; other site
889738007886	active site
889738007887	GDYXXLXY protein; Region: GDYXXLXY; pfam14345
889738007888	Domain of unknown function (DUF4401); Region: DUF4401; pfam14351
889738007889	3,4-dihydroxy-2-butanone 4-phosphate synthase; Provisional; Region: ribB; PRK03353
889738007890	3,4-dihydroxy-2-butanone 4-phosphate synthase [Coenzyme metabolism]; Region: RibB; COG0108
889738007891	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
889738007892	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
889738007893	motif II; other site
889738007894	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
889738007895	dimer interface [polypeptide binding]; other site
889738007896	substrate binding site [chemical binding]; other site
889738007897	ATP binding site [chemical binding]; other site
889738007898	LysM domain/BON superfamily protein; Provisional; Region: PRK11198
889738007899	BON domain; Region: BON; pfam04972
889738007900	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
889738007901	acyl carrier protein; Provisional; Region: acpP; PRK00982
889738007902	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
889738007903	3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830
889738007904	NAD(P) binding site [chemical binding]; other site
889738007905	homotetramer interface [polypeptide binding]; other site
889738007906	homodimer interface [polypeptide binding]; other site
889738007907	active site
889738007908	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
889738007909	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
889738007910	50S ribosomal protein L32; Validated; Region: rpmF; PRK01110
889738007911	Uncharacterized ACR, COG1399; Region: DUF177; pfam02620
889738007912	Protein of unknown function, DUF462; Region: DUF462; pfam04315
889738007913	Telomere recombination; Region: Sua5_yciO_yrdC; cl00305
889738007914	ScpA/B protein; Region: ScpA_ScpB; cl00598
889738007915	Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079
889738007916	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
889738007917	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
889738007918	RNA binding surface [nucleotide binding]; other site
889738007919	Pseudouridine synthase, Escherichia coli RluB like; Region: PseudoU_synth_RluB; cd02556
889738007920	probable active site [active]
889738007921	dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090
889738007922	AAA domain; Region: AAA_26; pfam13500
889738007923	biotin biosynthesis protein BioC; Region: BioC; TIGR02072
889738007924	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
889738007925	S-adenosylmethionine binding site [chemical binding]; other site
889738007926	8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958
889738007927	pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825
889738007928	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
889738007929	catalytic residue [active]
889738007930	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
889738007931	adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK06173
889738007932	inhibitor-cofactor binding pocket; inhibition site
889738007933	pyridoxal 5'-phosphate binding site [chemical binding]; other site
889738007934	catalytic residue [active]
889738007935	carboxylesterase BioH; Provisional; Region: PRK10349
889738007936	Trehalose-6-phosphatase [Carbohydrate transport and metabolism]; Region: OtsB; COG1877
889738007937	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
889738007938	active site
889738007939	motif I; other site
889738007940	motif II; other site
889738007941	Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788
889738007942	alpha,alpha-trehalose-phosphate synthase [UDP-forming]; Region: trehalose_OtsA; TIGR02400
889738007943	active site
889738007944	homotetramer interface [polypeptide binding]; other site
889738007945	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
889738007946	Major Facilitator Superfamily; Region: MFS_1; pfam07690
889738007947	putative substrate translocation pore; other site
889738007948	Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193
889738007949	Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907
889738007950	heme binding site [chemical binding]; other site
889738007951	ferroxidase pore; other site
889738007952	ferroxidase diiron center [ion binding]; other site
889738007953	NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956
889738007954	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114
889738007955	nucleotide binding pocket [chemical binding]; other site
889738007956	K-X-D-G motif; other site
889738007957	catalytic site [active]
889738007958	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
889738007959	NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119
889738007960	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027
889738007961	Dimer interface [polypeptide binding]; other site
889738007962	BRCT sequence motif; other site
889738007963	ZipA, C-terminal FtsZ-binding domain; Region: ZipA_C; pfam04354
889738007964	FtsZ protein binding site [polypeptide binding]; other site
889738007965	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
889738007966	AAA domain; Region: AAA_23; pfam13476
889738007967	Walker A/P-loop; other site
889738007968	ATP binding site [chemical binding]; other site
889738007969	Q-loop/lid; other site
889738007970	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
889738007971	ABC transporter signature motif; other site
889738007972	Walker B; other site
889738007973	D-loop; other site
889738007974	H-loop/switch region; other site
889738007975	Transcriptional regulators [Transcription]; Region: GntR; COG1802
889738007976	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
889738007977	DNA-binding site [nucleotide binding]; DNA binding site
889738007978	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
889738007979	Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340
889738007980	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057
889738007981	Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237
889738007982	pantothenate kinase; Reviewed; Region: PRK13322
889738007983	signal recognition particle protein; Provisional; Region: PRK10867
889738007984	SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963
889738007985	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
889738007986	GTP binding site [chemical binding]; other site
889738007987	Signal peptide binding domain; Region: SRP_SPB; pfam02978
889738007988	tRNA-dihydrouridine synthase C; Provisional; Region: PRK10550
889738007989	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
889738007990	FMN binding site [chemical binding]; other site
889738007991	active site
889738007992	catalytic residues [active]
889738007993	substrate binding site [chemical binding]; other site
889738007994	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
889738007995	trimer interface [polypeptide binding]; other site
889738007996	active site
889738007997	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
889738007998	Uncharacterized protein conserved in bacteria (DUF2062); Region: DUF2062; pfam09835
889738007999	Phosphorylase superfamily; Region: PNP_UDP_1; pfam01048
889738008000	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489
889738008001	MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037
889738008002	methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133
889738008003	catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814
889738008004	active site
889738008005	HIGH motif; other site
889738008006	KMSKS motif; other site
889738008007	Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957
889738008008	tRNA binding surface [nucleotide binding]; other site
889738008009	anticodon binding site; other site
889738008010	tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins.  This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties.  MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800
889738008011	dimer interface [polypeptide binding]; other site
889738008012	putative tRNA-binding site [nucleotide binding]; other site
889738008013	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
889738008014	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
889738008015	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
889738008016	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
889738008017	Major Facilitator Superfamily; Region: MFS_1; pfam07690
889738008018	putative substrate translocation pore; other site
889738008019	efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998
889738008020	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
889738008021	HlyD family secretion protein; Region: HlyD_3; pfam13437
889738008022	Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342
889738008023	Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291
889738008024	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
889738008025	catalytic residue [active]
889738008026	HI0933-like protein; Region: HI0933_like; pfam03486
889738008027	Conserved TM helix; Region: TM_helix; pfam05552
889738008028	Conserved TM helix; Region: TM_helix; pfam05552
889738008029	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
889738008030	Conserved TM helix; Region: TM_helix; pfam05552
889738008031	Conserved TM helix; Region: TM_helix; pfam05552
889738008032	ferredoxin-NADP reductase; Provisional; Region: PRK10926
889738008033	Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195
889738008034	FAD binding pocket [chemical binding]; other site
889738008035	FAD binding motif [chemical binding]; other site
889738008036	phosphate binding motif [ion binding]; other site
889738008037	beta-alpha-beta structure motif; other site
889738008038	NAD binding pocket [chemical binding]; other site
889738008039	putative DNA-binding transcriptional regulator; Provisional; Region: PRK10837
889738008040	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
889738008041	C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420
889738008042	putative dimerization interface [polypeptide binding]; other site
889738008043	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
889738008044	DNA-binding site [nucleotide binding]; DNA binding site
889738008045	RNA-binding motif; other site
889738008046	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
889738008047	active site
889738008048	NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777
889738008049	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
889738008050	NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846
889738008051	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
889738008052	NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590
889738008053	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662
889738008054	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
889738008055	NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715
889738008056	NADH:ubiquinone oxidoreductase subunit 6 (chain J) [Energy production and conversion]; Region: NuoJ; COG0839
889738008057	NADH dehydrogenase subunit J; Provisional; Region: PRK06433
889738008058	NADH-quinone oxidoreductase, chain I; Region: NuoI; TIGR01971
889738008059	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
889738008060	NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076
889738008061	Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650
889738008062	NADH dehydrogenase subunit G; Validated; Region: PRK08166
889738008063	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
889738008064	catalytic loop [active]
889738008065	iron binding site [ion binding]; other site
889738008066	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588
889738008067	MopB_NDH-1_NuoG2-N7: The second domain of the NuoG subunit (with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex in the respiratory...; Region: MopB_NDH-1_NuoG2-N7; cd02771
889738008068	[4Fe-4S] binding site [ion binding]; other site
889738008069	MopB_CT_NDH-1_NuoG2-N7: C-terminal region of the NuoG-like subunit (of the variant with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex...; Region: MopB_CT_NDH-1_NuoG2-N7; cd02788
889738008070	NADH dehydrogenase I subunit F; Provisional; Region: PRK11278
889738008071	SLBB domain; Region: SLBB; pfam10531
889738008072	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928
889738008073	NADH dehydrogenase subunit E; Validated; Region: PRK07539
889738008074	TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064
889738008075	putative dimer interface [polypeptide binding]; other site
889738008076	[2Fe-2S] cluster binding site [ion binding]; other site
889738008077	bifunctional NADH:ubiquinone oxidoreductase subunit C/D; Provisional; Region: PRK11742
889738008078	NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961
889738008079	NADH dehydrogenase subunit D; Validated; Region: PRK06075
889738008080	NADH dehydrogenase subunit B; Validated; Region: PRK06411
889738008081	NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602
889738008082	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
889738008083	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
889738008084	metal binding site [ion binding]; metal-binding site
889738008085	active site
889738008086	I-site; other site
889738008087	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
889738008088	dimerization interface [polypeptide binding]; other site
889738008089	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
889738008090	dimer interface [polypeptide binding]; other site
889738008091	phosphorylation site [posttranslational modification]
889738008092	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
889738008093	ATP binding site [chemical binding]; other site
889738008094	Mg2+ binding site [ion binding]; other site
889738008095	G-X-G motif; other site
889738008096	DNA-binding transcriptional regulator RstA; Provisional; Region: PRK10701
889738008097	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
889738008098	active site
889738008099	phosphorylation site [posttranslational modification]
889738008100	intermolecular recognition site; other site
889738008101	dimerization interface [polypeptide binding]; other site
889738008102	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
889738008103	DNA binding site [nucleotide binding]
889738008104	ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07207
889738008105	ATP cone domain; Region: ATP-cone; pfam03477
889738008106	Class I ribonucleotide reductase; Region: RNR_I; cd01679
889738008107	active site
889738008108	dimer interface [polypeptide binding]; other site
889738008109	catalytic residues [active]
889738008110	effector binding site; other site
889738008111	R2 peptide binding site; other site
889738008112	Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049
889738008113	dimer interface [polypeptide binding]; other site
889738008114	putative radical transfer pathway; other site
889738008115	diiron center [ion binding]; other site
889738008116	tyrosyl radical; other site
889738008117	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
889738008118	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c_3; pfam13589
889738008119	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
889738008120	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
889738008121	ATP binding site [chemical binding]; other site
889738008122	Mg2+ binding site [ion binding]; other site
889738008123	G-X-G motif; other site
889738008124	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
889738008125	Active Sites [active]
889738008126	Protein of unknown function (DUF4007); Region: DUF4007; pfam13182
889738008127	phage-associated protein, BcepMu gp16 family; Region: BcepMu_gp16; TIGR04111
889738008128	TnsA endonuclease N terminal; Region: Tn7_Tnp_TnsA_N; pfam08722
889738008129	Integrase core domain; Region: rve; pfam00665
889738008130	Bacterial TniB protein; Region: TniB; pfam05621
889738008131	AAA domain; Region: AAA_22; pfam13401
889738008132	TniQ; Region: TniQ; pfam06527
889738008133	Helix-turn-helix domain; Region: HTH_17; pfam12728
889738008134	membrane-bound PQQ-dependent dehydrogenase, glucose/quinate/shikimate family; Region: PQQ_membr_DH; TIGR03074
889738008135	Membrane-bound PQQ-dependent glucose dehydrogenase; Region: PQQ_mGDH; cd10280
889738008136	Trp docking motif [polypeptide binding]; other site
889738008137	putative active site [active]
889738008138	hypothetical protein; Provisional; Region: PRK08296
889738008139	hypothetical protein; Provisional; Region: PRK10281
889738008140	Transcriptional regulator [Transcription]; Region: LysR; COG0583
889738008141	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
889738008142	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
889738008143	dimerization interface [polypeptide binding]; other site
889738008144	Restriction endonuclease; Region: Mrr_cat; pfam04471
889738008145	AAA ATPase domain; Region: AAA_16; pfam13191
889738008146	AAA domain; Region: AAA_22; pfam13401
889738008147	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
889738008148	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
889738008149	Flavin Reductases; Region: FlaRed; cl00801
889738008150	methionine synthase; Provisional; Region: PRK01207
889738008151	CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311
889738008152	substrate binding site [chemical binding]; other site
889738008153	THF binding site; other site
889738008154	zinc-binding site [ion binding]; other site
889738008155	Domain of unknown function (DUF1852); Region: DUF1852; pfam08908
889738008156	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
889738008157	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
889738008158	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
889738008159	dimerization interface [polypeptide binding]; other site
889738008160	LysE type translocator; Region: LysE; cl00565
889738008161	Fatty acid desaturase; Region: FA_desaturase; pfam00487
889738008162	Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625
889738008163	SurA N-terminal domain; Region: SurA_N; pfam09312
889738008164	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
889738008165	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
889738008166	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
889738008167	M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like6; cd05664
889738008168	metal binding site [ion binding]; metal-binding site
889738008169	putative dimer interface [polypeptide binding]; other site
889738008170	Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; cl17479
889738008171	Transcriptional regulator [Transcription]; Region: LysR; COG0583
889738008172	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
889738008173	The C-teminal substrate binding domain of LysR-like nitrogen assimilation control (NAC) protein, contains the type 2 periplasmic binding fold; Region: PBP2_Nac; cd08433
889738008174	putative dimerization interface [polypeptide binding]; other site
889738008175	citrate-proton symporter; Provisional; Region: PRK15075
889738008176	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
889738008177	putative substrate translocation pore; other site
889738008178	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
889738008179	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
889738008180	nitrogen assimilation transcriptional regulator; Provisional; Region: PRK11233
889738008181	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
889738008182	The C-teminal substrate binding domain of LysR-like nitrogen assimilation control (NAC) protein, contains the type 2 periplasmic binding fold; Region: PBP2_Nac; cd08433
889738008183	putative dimerization interface [polypeptide binding]; other site
889738008184	tricarballylate dehydrogenase; Validated; Region: PRK08274
889738008185	Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730
889738008186	tricarballylate utilization protein B; Provisional; Region: PRK15033
889738008187	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
889738008188	nitrobindin heme-binding domain; Region: nitrobindin; cl10502
889738008189	CoA-transferase family III; Region: CoA_transf_3; pfam02515
889738008190	benzoate transport; Region: 2A0115; TIGR00895
889738008191	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
889738008192	putative substrate translocation pore; other site
889738008193	Glutaryl-CoA dehydrogenase; Region: GCD; cd01151
889738008194	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
889738008195	FAD binding site [chemical binding]; other site
889738008196	substrate binding pocket [chemical binding]; other site
889738008197	catalytic base [active]
889738008198	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
889738008199	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
889738008200	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
889738008201	dimerization interface [polypeptide binding]; other site
889738008202	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
889738008203	Alcohol dehydrogenases of the MDR family; Region: Zn_ADH8; cd08262
889738008204	putative NAD(P) binding site [chemical binding]; other site
889738008205	catalytic Zn binding site [ion binding]; other site
889738008206	Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816
889738008207	Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320
889738008208	active site
889738008209	purine riboside binding site [chemical binding]; other site
889738008210	quinolinate synthetase; Provisional; Region: PRK09375
889738008211	Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152
889738008212	heterotetramer interface [polypeptide binding]; other site
889738008213	active site pocket [active]
889738008214	cleavage site
889738008215	6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870
889738008216	methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901
889738008217	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
889738008218	DNA binding site [nucleotide binding]
889738008219	active site
889738008220	Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076
889738008221	Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230
889738008222	Copper resistance protein B precursor (CopB); Region: CopB; pfam05275
889738008223	copper-resistance protein, CopA family; Region: copper_res_A; TIGR01480
889738008224	Multicopper oxidase; Region: Cu-oxidase_3; pfam07732
889738008225	Multicopper oxidase; Region: Cu-oxidase; pfam00394
889738008226	Multicopper oxidase; Region: Cu-oxidase_2; pfam07731
889738008227	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
889738008228	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
889738008229	active site
889738008230	motif I; other site
889738008231	motif II; other site
889738008232	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
889738008233	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
889738008234	ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163
889738008235	substrate binding site [chemical binding]; other site
889738008236	hexamer interface [polypeptide binding]; other site
889738008237	metal binding site [ion binding]; metal-binding site
889738008238	Uncharacterized protein conserved in bacteria (DUF2218); Region: DUF2218; pfam09981
889738008239	S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821
889738008240	S-formylglutathione hydrolase; Region: PLN02442
889738008241	Peptidase C13 family; Region: Peptidase_C13; pfam01650
889738008242	Putative SAM-dependent methyltransferase; Region: SAM_MT; cl17517
889738008243	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
889738008244	Glycoprotease family; Region: Peptidase_M22; pfam00814
889738008245	Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663
889738008246	Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645
889738008247	trimer interface [polypeptide binding]; other site
889738008248	putative metal binding site [ion binding]; other site
889738008249	Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426
889738008250	putative active site [active]
889738008251	putative CoA binding site [chemical binding]; other site
889738008252	nudix motif; other site
889738008253	metal binding site [ion binding]; metal-binding site
889738008254	NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297
889738008255	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_4; cd04511
889738008256	nudix motif; other site
889738008257	Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; cl17479
889738008258	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
889738008259	Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147
889738008260	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
889738008261	Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079
889738008262	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
889738008263	pyridoxal 5'-phosphate binding site [chemical binding]; other site
889738008264	homodimer interface [polypeptide binding]; other site
889738008265	catalytic residue [active]
889738008266	Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572
889738008267	histidinol dehydrogenase; Region: hisD; TIGR00069
889738008268	NAD binding site [chemical binding]; other site
889738008269	dimerization interface [polypeptide binding]; other site
889738008270	product binding site; other site
889738008271	substrate binding site [chemical binding]; other site
889738008272	zinc binding site [ion binding]; other site
889738008273	catalytic residues [active]
889738008274	ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040
889738008275	ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686
889738008276	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
889738008277	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
889738008278	hinge; other site
889738008279	active site
889738008280	BolA-like protein; Region: BolA; cl00386
889738008281	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552
889738008282	30S subunit binding site; other site
889738008283	RNA polymerase factor sigma-54; Reviewed; Region: PRK05932
889738008284	Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309
889738008285	Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963
889738008286	Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552
889738008287	VacJ like lipoprotein; Region: VacJ; cl01073
889738008288	Sigma factor PP2C-like phosphatases; Region: PP2C_SIG; smart00331
889738008289	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
889738008290	anti sigma factor interaction site; other site
889738008291	regulatory phosphorylation site [posttranslational modification]; other site
889738008292	Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases); Region: nit; cd07572
889738008293	nitrilase; Region: PLN02798
889738008294	putative active site [active]
889738008295	catalytic triad [active]
889738008296	dimer interface [polypeptide binding]; other site
889738008297	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
889738008298	MarR family; Region: MarR; pfam01047
889738008299	peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561
889738008300	type II secretion system protein E; Region: type_II_gspE; TIGR02533
889738008301	PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129
889738008302	Walker A motif; other site
889738008303	ATP binding site [chemical binding]; other site
889738008304	Walker B motif; other site
889738008305	Protein of unknown function (DUF432); Region: DUF432; cl01027
889738008306	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
889738008307	Mechanosensitive ion channel; Region: MS_channel; pfam00924
889738008308	Predicted membrane protein (DUF2339); Region: DUF2339; pfam10101
889738008309	DNA polymerase I; Provisional; Region: PRK05755
889738008310	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
889738008311	active site
889738008312	metal binding site 1 [ion binding]; metal-binding site
889738008313	putative 5' ssDNA interaction site; other site
889738008314	metal binding site 3; metal-binding site
889738008315	metal binding site 2 [ion binding]; metal-binding site
889738008316	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
889738008317	putative DNA binding site [nucleotide binding]; other site
889738008318	putative metal binding site [ion binding]; other site
889738008319	DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139
889738008320	active site
889738008321	catalytic site [active]
889738008322	substrate binding site [chemical binding]; other site
889738008323	Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637
889738008324	active site
889738008325	DNA binding site [nucleotide binding]
889738008326	catalytic site [active]
889738008327	YGGT family; Region: YGGT; pfam02325
889738008328	pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880
889738008329	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232
889738008330	tRNA(Ile)-lysidine synthetase; Provisional; Region: tilS; PRK10660
889738008331	N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992
889738008332	TilS substrate binding domain; Region: TilS; pfam09179
889738008333	TilS substrate C-terminal domain; Region: TilS_C; pfam11734
889738008334	acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724
889738008335	guanosine pentaphosphate phosphohydrolase; Provisional; Region: PRK11031
889738008336	Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541
889738008337	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
889738008338	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
889738008339	catalytic residues [active]
889738008340	transcription termination factor Rho; Provisional; Region: rho; PRK09376
889738008341	Rho termination factor, N-terminal domain; Region: Rho_N; smart00959
889738008342	Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459
889738008343	RNA binding site [nucleotide binding]; other site
889738008344	Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128
889738008345	multimer interface [polypeptide binding]; other site
889738008346	Walker A motif; other site
889738008347	ATP binding site [chemical binding]; other site
889738008348	Walker B motif; other site
889738008349	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
889738008350	IHF dimer interface [polypeptide binding]; other site
889738008351	IHF - DNA interface [nucleotide binding]; other site
889738008352	phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629
889738008353	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
889738008354	putative tRNA-binding site [nucleotide binding]; other site
889738008355	B3/4 domain; Region: B3_4; pfam03483
889738008356	tRNA synthetase B5 domain; Region: B5; smart00874
889738008357	Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA,  PheRS is an...; Region: PheRS_beta_core; cd00769
889738008358	dimer interface [polypeptide binding]; other site
889738008359	motif 1; other site
889738008360	motif 3; other site
889738008361	motif 2; other site
889738008362	Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147
889738008363	phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488
889738008364	Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912
889738008365	Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496
889738008366	dimer interface [polypeptide binding]; other site
889738008367	motif 1; other site
889738008368	active site
889738008369	motif 2; other site
889738008370	motif 3; other site
889738008371	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
889738008372	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
889738008373	Coenzyme A binding pocket [chemical binding]; other site
889738008374	Domain of unknown function (DUF1768); Region: DUF1768; pfam08719
889738008375	Ribosomal protein L20; Region: Ribosomal_L20; cd07026
889738008376	23S rRNA binding site [nucleotide binding]; other site
889738008377	L21 binding site [polypeptide binding]; other site
889738008378	L13 binding site [polypeptide binding]; other site
889738008379	50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172
889738008380	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
889738008381	putative substrate translocation pore; other site
889738008382	H+ Antiporter protein; Region: 2A0121; TIGR00900
889738008383	Predicted membrane protein [Function unknown]; Region: COG1238
889738008384	GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972
889738008385	GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048
889738008386	C-terminal domain interface [polypeptide binding]; other site
889738008387	GSH binding site (G-site) [chemical binding]; other site
889738008388	dimer interface [polypeptide binding]; other site
889738008389	C-terminal, alpha helical domain of Escherichia coli YfcG Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YfcG_like; cd10291
889738008390	N-terminal domain interface [polypeptide binding]; other site
889738008391	putative dimer interface [polypeptide binding]; other site
889738008392	active site
889738008393	translation initiation factor IF-3; Reviewed; Region: infC; PRK00028
889738008394	Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707
889738008395	threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413
889738008396	TGS _ThrRS_N:  ThrRS (threonyl-tRNA Synthetase)  is a class II tRNA synthetase that couples threonine to its cognate tRNA.  In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667
889738008397	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
889738008398	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
889738008399	active site
889738008400	dimer interface [polypeptide binding]; other site
889738008401	motif 1; other site
889738008402	motif 2; other site
889738008403	motif 3; other site
889738008404	ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860
889738008405	anticodon binding site; other site
889738008406	acyl-CoA synthetase; Validated; Region: PRK08162
889738008407	Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles and Arabidopsis; Region: ttLC_FACS_AEE21_like; cd12118
889738008408	acyl-activating enzyme (AAE) consensus motif; other site
889738008409	putative active site [active]
889738008410	AMP binding site [chemical binding]; other site
889738008411	putative CoA binding site [chemical binding]; other site
889738008412	hypothetical protein; Provisional; Region: PRK05255
889738008413	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
889738008414	dimerization domain swap beta strand [polypeptide binding]; other site
889738008415	regulatory protein interface [polypeptide binding]; other site
889738008416	active site
889738008417	regulatory phosphorylation site [posttranslational modification]; other site
889738008418	glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416
889738008419	pantoate--beta-alanine ligase; Region: panC; TIGR00018
889738008420	Pantoate-beta-alanine ligase; Region: PanC; cd00560
889738008421	active site
889738008422	ATP-binding site [chemical binding]; other site
889738008423	pantoate-binding site; other site
889738008424	HXXH motif; other site
889738008425	Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557
889738008426	oligomerization interface [polypeptide binding]; other site
889738008427	active site
889738008428	metal binding site [ion binding]; metal-binding site
889738008429	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483
889738008430	catalytic center binding site [active]
889738008431	ATP binding site [chemical binding]; other site
889738008432	poly(A) polymerase; Region: pcnB; TIGR01942
889738008433	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
889738008434	active site
889738008435	NTP binding site [chemical binding]; other site
889738008436	metal binding triad [ion binding]; metal-binding site
889738008437	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
889738008438	Polymerase A arginine-rich C-terminus; Region: PolyA_pol_arg_C; pfam12626
889738008439	DNA uptake protein and related DNA-binding proteins [DNA replication, recombination, and repair]; Region: ComEA; COG1555
889738008440	Helix-hairpin-helix motif; Region: HHH; pfam00633
889738008441	nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562
889738008442	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528
889738008443	homodimer interface [polypeptide binding]; other site
889738008444	metal binding site [ion binding]; metal-binding site
889738008445	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529
889738008446	homodimer interface [polypeptide binding]; other site
889738008447	active site
889738008448	putative chemical substrate binding site [chemical binding]; other site
889738008449	metal binding site [ion binding]; metal-binding site
889738008450	short chain dehydrogenase; Provisional; Region: PRK08267
889738008451	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
889738008452	NAD(P) binding site [chemical binding]; other site
889738008453	active site
889738008454	HD domain; Region: HD_4; pfam13328
889738008455	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
889738008456	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
889738008457	synthetase active site [active]
889738008458	NTP binding site [chemical binding]; other site
889738008459	metal binding site [ion binding]; metal-binding site
889738008460	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
889738008461	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
889738008462	23S rRNA m(5)U1939 methyltransferase; Reviewed; Region: rumA; PRK13168
889738008463	TRAM domain; Region: TRAM; pfam01938
889738008464	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
889738008465	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
889738008466	S-adenosylmethionine binding site [chemical binding]; other site
889738008467	Uncharacterized bacterial subgroup of the DEDDy 3'-5' exonuclease domain of family-B DNA polymerases; Region: DNA_polB_like1_exo; cd05782
889738008468	active site
889738008469	catalytic site [active]
889738008470	substrate binding site [chemical binding]; other site
889738008471	Predicted 3'-5' exonuclease related to the exonuclease domain of PolB; Region: DNA_pol_B_exo2; pfam10108
889738008472	cysteine synthase B; Region: cysM; TIGR01138
889738008473	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
889738008474	dimer interface [polypeptide binding]; other site
889738008475	pyridoxal 5'-phosphate binding site [chemical binding]; other site
889738008476	catalytic residue [active]
889738008477	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
889738008478	dimer interface [polypeptide binding]; other site
889738008479	phosphorylation site [posttranslational modification]
889738008480	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
889738008481	ATP binding site [chemical binding]; other site
889738008482	Mg2+ binding site [ion binding]; other site
889738008483	G-X-G motif; other site
889738008484	Response regulator receiver domain; Region: Response_reg; pfam00072
889738008485	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
889738008486	active site
889738008487	phosphorylation site [posttranslational modification]
889738008488	intermolecular recognition site; other site
889738008489	dimerization interface [polypeptide binding]; other site
889738008490	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086
889738008491	enoyl-CoA hydratase; Provisional; Region: PRK07509
889738008492	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
889738008493	substrate binding site [chemical binding]; other site
889738008494	oxyanion hole (OAH) forming residues; other site
889738008495	trimer interface [polypeptide binding]; other site
889738008496	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
889738008497	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
889738008498	hydroxypyruvate isomerase; Region: OH-pyruv-isom; TIGR03234
889738008499	iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090
889738008500	retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327
889738008501	acetoacetyl-CoA reductase; Provisional; Region: PRK12935
889738008502	putative NAD(P) binding site [chemical binding]; other site
889738008503	active site
889738008504	NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233
889738008505	NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; COG1282
889738008506	Domain of unknown function (DUF3814); Region: DUF3814; pfam12769
889738008507	Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304
889738008508	NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288
889738008509	ligand binding site [chemical binding]; other site
889738008510	homodimer interface [polypeptide binding]; other site
889738008511	NAD(P) binding site [chemical binding]; other site
889738008512	trimer interface B [polypeptide binding]; other site
889738008513	trimer interface A [polypeptide binding]; other site
889738008514	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
889738008515	EamA-like transporter family; Region: EamA; pfam00892
889738008516	EamA-like transporter family; Region: EamA; pfam00892
889738008517	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
889738008518	homotrimer interaction site [polypeptide binding]; other site
889738008519	putative active site [active]
889738008520	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
889738008521	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
889738008522	putative substrate translocation pore; other site
889738008523	tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815
889738008524	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
889738008525	FMN binding site [chemical binding]; other site
889738008526	active site
889738008527	catalytic residues [active]
889738008528	substrate binding site [chemical binding]; other site
889738008529	Transcriptional regulator [Transcription]; Region: LysR; COG0583
889738008530	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
889738008531	The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414
889738008532	dimerization interface [polypeptide binding]; other site
889738008533	substrate binding pocket [chemical binding]; other site
889738008534	Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179
889738008535	Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755
889738008536	putative ATP binding site [chemical binding]; other site
889738008537	putative substrate interface [chemical binding]; other site
889738008538	This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function.  The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199
889738008539	homotrimer interaction site [polypeptide binding]; other site
889738008540	putative active site [active]
889738008541	aconitate hydratase; Validated; Region: PRK09277
889738008542	Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285
889738008543	substrate binding site [chemical binding]; other site
889738008544	ligand binding site [chemical binding]; other site
889738008545	Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580
889738008546	substrate binding site [chemical binding]; other site
889738008547	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
889738008548	active site
889738008549	Domain of unknown function (DUF4163); Region: DUF4163; pfam13739
889738008550	Protein of unknown function (DUF3298); Region: DUF3298; pfam11738
889738008551	Protein of unknown function (DUF3298); Region: DUF3298; pfam11738
889738008552	peptide chain release factor 3; Provisional; Region: prfC; PRK00741
889738008553	Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169
889738008554	G1 box; other site
889738008555	putative GEF interaction site [polypeptide binding]; other site
889738008556	GTP/Mg2+ binding site [chemical binding]; other site
889738008557	Switch I region; other site
889738008558	G2 box; other site
889738008559	G3 box; other site
889738008560	Switch II region; other site
889738008561	G4 box; other site
889738008562	G5 box; other site
889738008563	RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689
889738008564	transcriptional repressor BetI; Region: betaine_BetI; TIGR03384
889738008565	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
889738008566	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
889738008567	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
889738008568	MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300
889738008569	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
889738008570	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
889738008571	metal binding site [ion binding]; metal-binding site
889738008572	active site
889738008573	I-site; other site
889738008574	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
889738008575	ketol-acid reductoisomerase; Provisional; Region: PRK05479
889738008576	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991
889738008577	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450
889738008578	acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895
889738008579	N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878
889738008580	putative valine binding site [chemical binding]; other site
889738008581	dimer interface [polypeptide binding]; other site
889738008582	Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369
889738008583	acetolactate synthase 3 catalytic subunit; Validated; Region: PRK06466
889738008584	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
889738008585	PYR/PP interface [polypeptide binding]; other site
889738008586	dimer interface [polypeptide binding]; other site
889738008587	TPP binding site [chemical binding]; other site
889738008588	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
889738008589	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
889738008590	TPP-binding site [chemical binding]; other site
889738008591	dimer interface [polypeptide binding]; other site
889738008592	Domain of unknown function (DUF4124); Region: DUF4124; pfam13511
889738008593	leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390
889738008594	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
889738008595	HIGH motif; other site
889738008596	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
889738008597	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
889738008598	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
889738008599	active site
889738008600	KMSKS motif; other site
889738008601	Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958
889738008602	tRNA binding surface [nucleotide binding]; other site
889738008603	Lipopolysaccharide-assembly; Region: LptE; pfam04390
889738008604	DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574
889738008605	DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144
889738008606	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
889738008607	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
889738008608	HlyD family secretion protein; Region: HlyD_3; pfam13437
889738008609	macrolide transporter ATP-binding /permease protein; Provisional; Region: PRK10535
889738008610	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
889738008611	Walker A/P-loop; other site
889738008612	ATP binding site [chemical binding]; other site
889738008613	Q-loop/lid; other site
889738008614	ABC transporter signature motif; other site
889738008615	Walker B; other site
889738008616	D-loop; other site
889738008617	H-loop/switch region; other site
889738008618	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
889738008619	FtsX-like permease family; Region: FtsX; pfam02687
889738008620	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
889738008621	Enoyl-[acyl-carrier-protein]; Region: FabI; COG0623
889738008622	Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372
889738008623	NAD binding site [chemical binding]; other site
889738008624	homotetramer interface [polypeptide binding]; other site
889738008625	homodimer interface [polypeptide binding]; other site
889738008626	substrate binding site [chemical binding]; other site
889738008627	active site
889738008628	Bax inhibitor 1 like; Region: BaxI_1; cl17691
889738008629	DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135
889738008630	catalytic site [active]
889738008631	putative active site [active]
889738008632	putative substrate binding site [chemical binding]; other site
889738008633	dimer interface [polypeptide binding]; other site
889738008634	GTPase RsgA; Reviewed; Region: PRK12288
889738008635	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
889738008636	RNA binding site [nucleotide binding]; other site
889738008637	Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854
889738008638	GTPase/Zn-binding domain interface [polypeptide binding]; other site
889738008639	GTP/Mg2+ binding site [chemical binding]; other site
889738008640	G4 box; other site
889738008641	G5 box; other site
889738008642	G1 box; other site
889738008643	Switch I region; other site
889738008644	G2 box; other site
889738008645	G3 box; other site
889738008646	Switch II region; other site
889738008647	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
889738008648	active site residue [active]
889738008649	Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418
889738008650	GSH binding site [chemical binding]; other site
889738008651	catalytic residues [active]
889738008652	preprotein translocase subunit SecB; Validated; Region: PRK05751
889738008653	SecA binding site; other site
889738008654	Preprotein binding site; other site
889738008655	Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091
889738008656	4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648
889738008657	3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK09116
889738008658	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
889738008659	dimer interface [polypeptide binding]; other site
889738008660	active site
889738008661	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
889738008662	3-oxoacyl-(acyl-carrier-protein) reductase, putative; Region: fabG_rel; TIGR01831
889738008663	NAD(P) binding site [chemical binding]; other site
889738008664	homotetramer interface [polypeptide binding]; other site
889738008665	homodimer interface [polypeptide binding]; other site
889738008666	active site
889738008667	Domain of unknown function, appears to be related to a diverse group of beta-hydroxydecanoyl ACP dehydratases (FabA) and beta-hydroxyacyl ACP dehydratases (FabZ). This group appears to lack the conserved active site histidine of FabA and FabZ; Region: FabA_like; cd01289
889738008668	putative active site 1 [active]
889738008669	3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK09185
889738008670	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
889738008671	dimer interface [polypeptide binding]; other site
889738008672	active site
889738008673	Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644
889738008674	Predicted exporter [General function prediction only]; Region: COG4258
889738008675	Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl17548
889738008676	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
889738008677	active site
889738008678	Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332
889738008679	active sites [active]
889738008680	tetramer interface [polypeptide binding]; other site
889738008681	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
889738008682	putative acyl-acceptor binding pocket; other site
889738008683	DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179
889738008684	Ligand binding site; other site
889738008685	Putative Catalytic site; other site
889738008686	DXD motif; other site
889738008687	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
889738008688	Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365
889738008689	acyl-activating enzyme (AAE) consensus motif; other site
889738008690	active site
889738008691	AMP binding site [chemical binding]; other site
889738008692	CoA binding site [chemical binding]; other site
889738008693	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
889738008694	active site 2 [active]
889738008695	active site 1 [active]
889738008696	Predicted membrane protein [Function unknown]; Region: COG4648
889738008697	acyl carrier protein; Provisional; Region: PRK05350
889738008698	Phosphopantetheine attachment site; Region: PP-binding; cl09936
889738008699	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
889738008700	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
889738008701	putative acyl-acceptor binding pocket; other site
889738008702	Beta-ketoacyl synthase, N-terminal domain; Region: Ketoacyl-synt_2; pfam13723
889738008703	GTP-binding protein Der; Reviewed; Region: PRK00093
889738008704	EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894
889738008705	G1 box; other site
889738008706	GTP/Mg2+ binding site [chemical binding]; other site
889738008707	Switch I region; other site
889738008708	G2 box; other site
889738008709	Switch II region; other site
889738008710	G3 box; other site
889738008711	G4 box; other site
889738008712	G5 box; other site
889738008713	EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895
889738008714	G1 box; other site
889738008715	GTP/Mg2+ binding site [chemical binding]; other site
889738008716	Switch I region; other site
889738008717	G2 box; other site
889738008718	G3 box; other site
889738008719	Switch II region; other site
889738008720	G4 box; other site
889738008721	G5 box; other site
889738008722	outer membrane assembly lipoprotein YfgL; Region: assembly_YfgL; TIGR03300
889738008723	PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493
889738008724	Trp docking motif [polypeptide binding]; other site
889738008725	active site
889738008726	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2976
889738008727	Uncharacterized protein conserved in bacteria (DUF2133); Region: DUF2133; pfam09976
889738008728	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
889738008729	TPR motif; other site
889738008730	binding surface
889738008731	histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037
889738008732	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
889738008733	dimer interface [polypeptide binding]; other site
889738008734	motif 1; other site
889738008735	active site
889738008736	motif 2; other site
889738008737	motif 3; other site
889738008738	HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859
889738008739	anticodon binding site; other site
889738008740	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366
889738008741	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
889738008742	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
889738008743	Helix-turn-helix domain; Region: HTH_25; pfam13413
889738008744	Domain of unknown function (DUF4115); Region: DUF4115; pfam13464
889738008745	type IV pilus biogenesis/stability protein PilW; Region: type_IV_pilW; TIGR02521
889738008746	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
889738008747	TPR motif; other site
889738008748	binding surface
889738008749	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
889738008750	TPR motif; other site
889738008751	binding surface
889738008752	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
889738008753	binding surface
889738008754	TPR motif; other site
889738008755	ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK11194
889738008756	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
889738008757	FeS/SAM binding site; other site
889738008758	Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413
889738008759	active site
889738008760	multimer interface [polypeptide binding]; other site
889738008761	Iron-sulphur cluster assembly; Region: Fe-S_assembly; pfam04384
889738008762	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
889738008763	PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610
889738008764	active site
889738008765	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
889738008766	This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814
889738008767	carboxy-terminal protease; Provisional; Region: PRK11186
889738008768	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
889738008769	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
889738008770	protein binding site [polypeptide binding]; other site
889738008771	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
889738008772	Catalytic dyad [active]
889738008773	C-terminal domain of tail specific protease (DUF3340); Region: DUF3340; pfam11818
889738008774	beta-hexosaminidase; Provisional; Region: PRK05337
889738008775	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
889738008776	Leucine carboxyl methyltransferase; Region: LCM; pfam04072
889738008777	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
889738008778	Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079
889738008779	gamma-glutamyl phosphate reductase; Region: proA; TIGR00407
889738008780	putative catalytic cysteine [active]
889738008781	NADP+-dependent non-phosphorylating glyceraldehyde 3-phosphate dehydrogenase and ALDH family 11; Region: ALDH_F11_NP-GAPDH; cd07082
889738008782	NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012
889738008783	tetrameric interface [polypeptide binding]; other site
889738008784	activator binding site; other site
889738008785	NADP binding site [chemical binding]; other site
889738008786	substrate binding site [chemical binding]; other site
889738008787	catalytic residues [active]
889738008788	Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021
889738008789	ATP-binding site [chemical binding]; other site
889738008790	Gluconate-6-phosphate binding site [chemical binding]; other site
889738008791	Shikimate kinase; Region: SKI; pfam01202
889738008792	GntP family permease; Region: GntP_permease; pfam02447
889738008793	fructuronate transporter; Provisional; Region: PRK10034; cl15264
889738008794	keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718
889738008795	KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452
889738008796	active site
889738008797	intersubunit interface [polypeptide binding]; other site
889738008798	catalytic residue [active]
889738008799	phosphogluconate dehydratase; Validated; Region: PRK09054
889738008800	6-phosphogluconate dehydratase; Region: edd; TIGR01196
889738008801	propionate/acetate kinase; Provisional; Region: PRK12379
889738008802	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
889738008803	nucleotide binding site [chemical binding]; other site
889738008804	Butyrate kinase [Energy production and conversion]; Region: COG3426
889738008805	phosphate acetyltransferase; Reviewed; Region: PRK05632
889738008806	DRTGG domain; Region: DRTGG; pfam07085
889738008807	phosphotransacetylase; Reviewed; Region: eutD; PRK09653
889738008808	Fumarate hydratase (Fumerase); Region: Fumerase; pfam05681
889738008809	Fumarase C-terminus; Region: Fumerase_C; pfam05683
889738008810	Uncharacterized protein conserved in bacteria (DUF2059); Region: DUF2059; pfam09832
889738008811	Protein of unknown function (DUF2846); Region: DUF2846; pfam11008
889738008812	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
889738008813	ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689
889738008814	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
889738008815	Walker A motif; other site
889738008816	ATP binding site [chemical binding]; other site
889738008817	Walker B motif; other site
889738008818	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
889738008819	Clp protease; Region: CLP_protease; pfam00574
889738008820	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
889738008821	oligomer interface [polypeptide binding]; other site
889738008822	active site residues [active]
889738008823	trigger factor; Provisional; Region: tig; PRK01490
889738008824	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
889738008825	Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698
889738008826	Outer membrane receptor for monomeric catechols [Inorganic ion transport and metabolism]; Region: Fiu; COG4774
889738008827	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
889738008828	N-terminal plug; other site
889738008829	ligand-binding site [chemical binding]; other site
889738008830	Fe(II)-dependent oxygenase superfamily protein; Provisional; Region: PRK05467
889738008831	2-isopropylmalate synthase; Validated; Region: PRK03739
889738008832	Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942
889738008833	active site
889738008834	catalytic residues [active]
889738008835	metal binding site [ion binding]; metal-binding site
889738008836	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917
889738008837	homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175
889738008838	homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392
889738008839	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
889738008840	S-adenosylmethionine binding site [chemical binding]; other site
889738008841	Sel1-like repeats; Region: SEL1; smart00671
889738008842	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
889738008843	Sel1-like repeats; Region: SEL1; smart00671
889738008844	NTPase/HAM1.  This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515
889738008845	active site
889738008846	dimerization interface [polypeptide binding]; other site
889738008847	Membrane transport protein; Region: Mem_trans; cl09117
889738008848	mttA/Hcf106 family; Region: MttA_Hcf106; cl00788
889738008849	twin arginine-targeting protein translocase TatB; Region: tatB; TIGR01410
889738008850	Sec-independent protein translocase protein (TatC); Region: TatC; cl00521
889738008851	Bacterial protein of unknown function (DUF839); Region: DUF839; pfam05787
889738008852	Predicted phosphatase [General function prediction only]; Region: PhoX; COG3211
889738008853	NRDE protein; Region: NRDE; cl01315
889738008854	prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK12437
889738008855	thymidylate synthase; Reviewed; Region: thyA; PRK01827
889738008856	Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351
889738008857	dimerization interface [polypeptide binding]; other site
889738008858	active site
889738008859	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
889738008860	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209
889738008861	folate binding site [chemical binding]; other site
889738008862	NADP+ binding site [chemical binding]; other site
889738008863	Domain of unknown function (DUF4105); Region: DUF4105; pfam13387
889738008864	methionine sulfoxide reductase A; Provisional; Region: PRK14054
889738008865	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
889738008866	Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472
889738008867	Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811
889738008868	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
889738008869	formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027
889738008870	N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875
889738008871	Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648
889738008872	putative active site [active]
889738008873	putative substrate binding site [chemical binding]; other site
889738008874	putative cosubstrate binding site; other site
889738008875	catalytic site [active]
889738008876	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
889738008877	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
889738008878	Bacterial transcriptional repressor; Region: TetR; pfam13972
889738008879	aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381
889738008880	Coniferyl aldehyde dehydrogenase-like; Region: ALDH_CALDH_CalB; cd07133
889738008881	NAD(P) binding site [chemical binding]; other site
889738008882	catalytic residues [active]
889738008883	50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359
889738008884	50S ribosomal protein L33; Validated; Region: rpmG; PRK00595
889738008885	putative cation:proton antiport protein; Provisional; Region: PRK10669
889738008886	Kef-type K+ transport system, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: RosB; COG4651
889738008887	TrkA-N domain; Region: TrkA_N; pfam02254
889738008888	ASC-1 homology or ASCH domain, a small beta-barrel domain found in all three kingdoms of life. ASCH resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as an RNA-binding domain during coactivation; Region: ASCH; cl01020
889738008889	RNA-binding proteins (RRM domain) [General function prediction only]; Region: COG0724
889738008890	RNA recognition motif; Region: RRM; smart00360
889738008891	Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
889738008892	Part of AAA domain; Region: AAA_19; pfam13245
889738008893	Family description; Region: UvrD_C_2; pfam13538
889738008894	Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247
889738008895	DNA topoisomerase I subunit omega; Validated; Region: PRK07561
889738008896	TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I.   Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363
889738008897	active site
889738008898	interdomain interaction site; other site
889738008899	putative metal-binding site [ion binding]; other site
889738008900	nucleotide binding site [chemical binding]; other site
889738008901	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
889738008902	domain I; other site
889738008903	DNA binding groove [nucleotide binding]
889738008904	phosphate binding site [ion binding]; other site
889738008905	domain II; other site
889738008906	domain III; other site
889738008907	nucleotide binding site [chemical binding]; other site
889738008908	catalytic site [active]
889738008909	domain IV; other site
889738008910	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
889738008911	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
889738008912	Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272
889738008913	Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272
889738008914	Ammonium Transporter Family; Region: Ammonium_transp; cl03012
889738008915	Predicted transcriptional regulators [Transcription]; Region: COG1733
889738008916	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
889738008917	Arginate lyase and other MDR family members; Region: AL_MDR; cd08252
889738008918	zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817
889738008919	putative NAD(P) binding site [chemical binding]; other site
889738008920	dimer interface [polypeptide binding]; other site
889738008921	SlyX; Region: SlyX; pfam04102
889738008922	ABC transporter ATPase component; Reviewed; Region: PRK11147
889738008923	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
889738008924	Walker A/P-loop; other site
889738008925	ATP binding site [chemical binding]; other site
889738008926	Q-loop/lid; other site
889738008927	ABC transporter signature motif; other site
889738008928	Walker B; other site
889738008929	D-loop; other site
889738008930	H-loop/switch region; other site
889738008931	ABC transporter; Region: ABC_tran_2; pfam12848
889738008932	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
889738008933	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
889738008934	Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279
889738008935	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
889738008936	putative acyl-acceptor binding pocket; other site
889738008937	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
889738008938	This family is most closely related to the GT1 family of glycosyltransferases. WavL in Vibrio cholerae has been shown to be involved in the biosynthesis of the lipopolysaccharide core; Region: GT1_WavL_like; cd03819
889738008939	putative ADP-binding pocket [chemical binding]; other site
889738008940	glutamate/aspartate:proton symporter; Provisional; Region: gltP; PRK11283
889738008941	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
889738008942	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
889738008943	putative catalytic site [active]
889738008944	putative metal binding site [ion binding]; other site
889738008945	putative phosphate binding site [ion binding]; other site
889738008946	aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK06598
889738008947	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
889738008948	FimV N-terminal domain; Region: FimV_core; TIGR03505
889738008949	Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963
889738008950	active site
889738008951	homodimer interface [polypeptide binding]; other site
889738008952	tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021
889738008953	Eukaryotic and bacterial pseudouridine synthases similar to E.  coli TruA; Region: PseudoU_synth_EcTruA; cd02570
889738008954	dimerization interface 3.5A [polypeptide binding]; other site
889738008955	active site
889738008956	Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625
889738008957	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
889738008958	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
889738008959	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
889738008960	rRNA binding site [nucleotide binding]; other site
889738008961	predicted 30S ribosome binding site; other site
889738008962	Protein of unknown function (DUF1311); Region: DUF1311; cl01530
889738008963	3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772
889738008964	tartrate dehydrogenase; Region: TTC; TIGR02089
889738008965	isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641
889738008966	Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577
889738008967	substrate binding site [chemical binding]; other site
889738008968	3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402
889738008969	3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583
889738008970	substrate binding site [chemical binding]; other site
889738008971	ligand binding site [chemical binding]; other site
889738008972	Predicted membrane protein (DUF2061); Region: DUF2061; pfam09834
889738008973	Transcriptional regulator [Transcription]; Region: LysR; COG0583
889738008974	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
889738008975	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
889738008976	dimerization interface [polypeptide binding]; other site
889738008977	Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560
889738008978	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
889738008979	Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671
889738008980	putative active site [active]
889738008981	Ap4A binding site [chemical binding]; other site
889738008982	nudix motif; other site
889738008983	putative metal binding site [ion binding]; other site
889738008984	Signal transduction protein containing GAF and PtsI domains [Signal transduction mechanisms]; Region: PtsP; COG3605
889738008985	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
889738008986	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
889738008987	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
889738008988	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
889738008989	catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061
889738008990	Heme-dependent peroxidases similar to plant peroxidases; Region: plant_peroxidase_like; cl00196
889738008991	heme binding site [chemical binding]; other site
889738008992	C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200
889738008993	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
889738008994	Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706
889738008995	DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906
889738008996	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
889738008997	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
889738008998	dimerization interface [polypeptide binding]; other site
889738008999	Protein of unknown function (DUF1345); Region: DUF1345; pfam07077
889738009000	GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972
889738009001	GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046
889738009002	putative C-terminal domain interface [polypeptide binding]; other site
889738009003	putative GSH binding site (G-site) [chemical binding]; other site
889738009004	putative dimer interface [polypeptide binding]; other site
889738009005	C-terminal, alpha helical domain of an unknown subfamily 8 of Glutathione S-transferases; Region: GST_C_8; cd03207
889738009006	dimer interface [polypeptide binding]; other site
889738009007	N-terminal domain interface [polypeptide binding]; other site
889738009008	putative substrate binding pocket (H-site) [chemical binding]; other site
889738009009	Predicted transcriptional regulator [Transcription]; Region: COG2378
889738009010	HTH domain; Region: HTH_11; pfam08279
889738009011	WYL domain; Region: WYL; pfam13280
889738009012	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
889738009013	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
889738009014	motif II; other site
889738009015	23S rRNA pseudouridylate synthase C; Provisional; Region: PRK11025
889738009016	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
889738009017	RNA binding surface [nucleotide binding]; other site
889738009018	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
889738009019	active site
889738009020	Ribonucleases G and E [Translation, ribosomal structure and biogenesis]; Region: CafA; COG1530
889738009021	S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453
889738009022	homodimer interface [polypeptide binding]; other site
889738009023	oligonucleotide binding site [chemical binding]; other site
889738009024	long-chain-acyl-CoA synthetase; Validated; Region: PRK08279
889738009025	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
889738009026	Fatty acid transport proteins (FATP) play dual roles as fatty acid transporters and its activation enzymes; Region: FATP_FACS; cd05940
889738009027	acyl-activating enzyme (AAE) consensus motif; other site
889738009028	putative AMP binding site [chemical binding]; other site
889738009029	putative active site [active]
889738009030	putative CoA binding site [chemical binding]; other site
889738009031	Transcriptional regulator [Transcription]; Region: LysR; COG0583
889738009032	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
889738009033	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472
889738009034	putative effector binding pocket; other site
889738009035	putative dimerization interface [polypeptide binding]; other site
889738009036	short chain dehydrogenase; Provisional; Region: PRK12744
889738009037	tetrahydroxynaphthalene/trihydroxynaphthalene reductase-like, classical (c) SDRs; Region: THN_reductase-like_SDR_c; cd05362
889738009038	NADP binding site [chemical binding]; other site
889738009039	homodimer interface [polypeptide binding]; other site
889738009040	active site
889738009041	substrate binding site [chemical binding]; other site
889738009042	HemN family oxidoreductase; Provisional; Region: PRK05660
889738009043	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
889738009044	FeS/SAM binding site; other site
889738009045	HemN C-terminal domain; Region: HemN_C; pfam06969
889738009046	Protein of unknown function, DUF606; Region: DUF606; pfam04657
889738009047	multidrug efflux protein; Reviewed; Region: PRK01766
889738009048	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131
889738009049	cation binding site [ion binding]; other site
889738009050	Dibenzothiophene (DBT) desulfurization enzyme C; Region: DszC; cd01163
889738009051	sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022
889738009052	Flavin binding site [chemical binding]; other site
889738009053	sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022
889738009054	Dibenzothiophene (DBT) desulfurization enzyme C; Region: DszC; cd01163
889738009055	Flavin binding site [chemical binding]; other site
889738009056	Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661
889738009057	ABC1 family; Region: ABC1; pfam03109
889738009058	50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678
889738009059	HopJ type III effector protein; Region: HopJ; pfam08888
889738009060	chromosome condensation membrane protein; Provisional; Region: PRK14196
889738009061	Glutathione-dependent formaldehyde-activating enzyme; Region: GFA; pfam04828
889738009062	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
889738009063	uncharacterized flavoprotein, PP_4765 family; Region: flavo_PP4765; TIGR03862
889738009064	Putative methyltransferase; Region: Methyltransf_4; cl17290
889738009065	Domain of unknown function (DUF329); Region: DUF329; pfam03884
889738009066	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
889738009067	ferrochelatase; Reviewed; Region: hemH; PRK00035
889738009068	Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411
889738009069	C-terminal domain interface [polypeptide binding]; other site
889738009070	active site
889738009071	Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419
889738009072	active site
889738009073	N-terminal domain interface [polypeptide binding]; other site
889738009074	Domain of unknown function (DUF4062); Region: DUF4062; pfam13271
889738009075	glutamate racemase; Provisional; Region: PRK00865
889738009076	aspartate racemase; Region: asp_race; TIGR00035
889738009077	Protein of unknown function (DUF1285); Region: DUF1285; pfam06938
889738009078	Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644
889738009079	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
889738009080	Electron transfer flavoprotein-ubiquinone oxidoreductase; Region: ETF_QO; pfam05187
889738009081	Ferredoxin-like protein [Energy production and conversion]; Region: FixX; COG2440
889738009082	SirA (also known as UvrY,  and YhhP) belongs to a family of two-component response regulators that controls secondary metabolism and virulence. The other member of this two-component system is a sensor kinase called BarA which phosphorylates SirA.  A...; Region: SirA; cd03423
889738009083	CPxP  motif; other site
889738009084	FOG: CBS domain [General function prediction only]; Region: COG0517
889738009085	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
889738009086	Transporter associated domain; Region: CorC_HlyC; smart01091
889738009087	apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302
889738009088	Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571
889738009089	putative active site [active]
889738009090	catalytic triad [active]
889738009091	putative dimer interface [polypeptide binding]; other site
889738009092	tRNA-binding-domain-containing CsaA-like proteins. CsaA is a molecular chaperone with export related activities. CsaA has a putative tRNA binding activity. The functional unit of CsaA is a homodimer and this domain acts as a dimerization domain; Region: tRNA_bind_CsaA; cd02798
889738009093	dimer interface [polypeptide binding]; other site
889738009094	putative tRNA-binding site [nucleotide binding]; other site
889738009095	type II secretion system protein G; Region: typeII_sec_gspG; TIGR01710
889738009096	Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334
889738009097	type II secretion system protein F; Region: GspF; TIGR02120
889738009098	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
889738009099	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
889738009100	primosome assembly protein PriA; Validated; Region: PRK05580
889738009101	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
889738009102	ATP binding site [chemical binding]; other site
889738009103	putative Mg++ binding site [ion binding]; other site
889738009104	helicase superfamily c-terminal domain; Region: HELICc; smart00490
889738009105	ATP-binding site [chemical binding]; other site
889738009106	glutathione-regulated potassium-efflux system protein KefC; Provisional; Region: PRK03562
889738009107	transporter, monovalent cation:proton antiporter-2 (CPA2) family; Region: 2a37; TIGR00932
889738009108	TrkA-N domain; Region: TrkA_N; pfam02254
889738009109	Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114
889738009110	Heat shock protein 33 (Hsp33):  Cytosolic protein that acts as a molecular chaperone under oxidative conditions.  In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498
889738009111	dimerization interface [polypeptide binding]; other site
889738009112	domain crossover interface; other site
889738009113	redox-dependent activation switch; other site
889738009114	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
889738009115	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
889738009116	chaperone protein DnaJ; Region: DnaJ_bact; TIGR02349
889738009117	HSP70 interaction site [polypeptide binding]; other site
889738009118	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
889738009119	substrate binding site [polypeptide binding]; other site
889738009120	dimer interface [polypeptide binding]; other site
889738009121	MerR HTH family regulatory protein; Region: MerR_2; pfam13591
889738009122	CorA-like Mg2+ transporter protein; Region: CorA; pfam01544
889738009123	Thermotoga maritima CorA-like family; Region: TmCorA-like; cd12822
889738009124	oligomer interface [polypeptide binding]; other site
889738009125	metal binding site [ion binding]; metal-binding site
889738009126	metal binding site [ion binding]; metal-binding site
889738009127	putative Cl binding site [ion binding]; other site
889738009128	aspartate ring; other site
889738009129	basic sphincter; other site
889738009130	hydrophobic gate; other site
889738009131	periplasmic entrance; other site
889738009132	polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824
889738009133	Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363
889738009134	RNase E interface [polypeptide binding]; other site
889738009135	trimer interface [polypeptide binding]; other site
889738009136	Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726
889738009137	Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364
889738009138	RNase E interface [polypeptide binding]; other site
889738009139	trimer interface [polypeptide binding]; other site
889738009140	active site
889738009141	Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393
889738009142	putative nucleic acid binding region [nucleotide binding]; other site
889738009143	G-X-X-G motif; other site
889738009144	S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase  is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472
889738009145	RNA binding site [nucleotide binding]; other site
889738009146	domain interface; other site
889738009147	Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353
889738009148	16S/18S rRNA binding site [nucleotide binding]; other site
889738009149	S13e-L30e interaction site [polypeptide binding]; other site
889738009150	25S rRNA binding site [nucleotide binding]; other site
889738009151	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
889738009152	Beta-lactamase; Region: Beta-lactamase; pfam00144
889738009153	AAA domain; Region: AAA_30; pfam13604
889738009154	AAA domain; Region: AAA_22; pfam13401
889738009155	Family description; Region: UvrD_C_2; pfam13538
889738009156	Part of AAA domain; Region: AAA_19; pfam13245
889738009157	ATP-dependent exoDNAse (exonuclease V) beta subunit (contains helicase and exonuclease domains) [DNA replication, recombination, and repair]; Region: RecB; COG1074
889738009158	Family description; Region: UvrD_C_2; pfam13538
889738009159	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
889738009160	Exodeoxyribonuclease V, gamma subunit; Region: Exonuc_V_gamma; pfam04257
889738009161	exonuclease V subunit gamma; Provisional; Region: recC; PRK11069
889738009162	Uncharacterized protein/domain associated with GTPases [Function unknown]; Region: COG3597
889738009163	Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971
889738009164	polyphosphate:AMP phosphotransferase; Region: poly_P_AMP_trns; TIGR03708
889738009165	Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971
889738009166	Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226
889738009167	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
889738009168	S-adenosylmethionine binding site [chemical binding]; other site
889738009169	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4627
889738009170	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3165
889738009171	ABC1 family; Region: ABC1; cl17513
889738009172	2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982
889738009173	2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654
889738009174	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
889738009175	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
889738009176	bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759
889738009177	phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051
889738009178	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534
889738009179	metal binding site [ion binding]; metal-binding site
889738009180	Family description; Region: UvrD_C_2; pfam13538
889738009181	AAA domain; Region: AAA_23; pfam13476
889738009182	putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12648
889738009183	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
889738009184	Domain of unknown function (DUF4040); Region: DUF4040; pfam13244
889738009185	Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111
889738009186	putative monovalent cation/H+ antiporter subunit B; Reviewed; Region: PRK12573
889738009187	putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK09094
889738009188	putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12666
889738009189	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
889738009190	putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK08965
889738009191	Multiple resistance and pH regulation protein F (MrpF / PhaF); Region: MrpF_PhaF; cl09154
889738009192	putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12674
889738009193	ribosome-binding factor A; Provisional; Region: PRK13816
889738009194	translation initiation factor IF-2; Region: IF-2; TIGR00487
889738009195	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
889738009196	Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887
889738009197	G1 box; other site
889738009198	putative GEF interaction site [polypeptide binding]; other site
889738009199	GTP/Mg2+ binding site [chemical binding]; other site
889738009200	Switch I region; other site
889738009201	G2 box; other site
889738009202	G3 box; other site
889738009203	Switch II region; other site
889738009204	G4 box; other site
889738009205	G5 box; other site
889738009206	This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702
889738009207	Translation-initiation factor 2; Region: IF-2; pfam11987
889738009208	mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692
889738009209	transcription elongation factor NusA; Validated; Region: nusA; PRK09202
889738009210	NusA N-terminal domain; Region: NusA_N; pfam08529
889738009211	S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455
889738009212	RNA binding site [nucleotide binding]; other site
889738009213	homodimer interface [polypeptide binding]; other site
889738009214	NusA-like KH domain; Region: KH_5; pfam13184
889738009215	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
889738009216	G-X-X-G motif; other site
889738009217	transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954
889738009218	transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954
889738009219	Sm and related proteins; Region: Sm_like; cl00259
889738009220	ribosome maturation protein RimP; Reviewed; Region: PRK00092
889738009221	Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734
889738009222	putative oligomer interface [polypeptide binding]; other site
889738009223	putative RNA binding site [nucleotide binding]; other site
889738009224	Preprotein translocase SecG subunit; Region: SecG; pfam03840
889738009225	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
889738009226	triosephosphate isomerase; Provisional; Region: PRK14567
889738009227	substrate binding site [chemical binding]; other site
889738009228	dimer interface [polypeptide binding]; other site
889738009229	catalytic triad [active]
889738009230	type IV-A pilus assembly ATPase PilB; Region: type_IV_pilB; TIGR02538
889738009231	Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157
889738009232	PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129
889738009233	Walker A motif; other site
889738009234	ATP binding site [chemical binding]; other site
889738009235	Walker B motif; other site
889738009236	Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459
889738009237	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
889738009238	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
889738009239	Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989
889738009240	Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750
889738009241	Type IV leader peptidase family; Region: Peptidase_A24; pfam01478
889738009242	Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237
889738009243	Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022
889738009244	CoA-binding site [chemical binding]; other site
889738009245	ATP-binding [chemical binding]; other site
889738009246	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
889738009247	EamA-like transporter family; Region: EamA; pfam00892
889738009248	23S rRNA (guanosine-2'-O-)-methyltransferase; Provisional; Region: PRK11181
889738009249	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032
889738009250	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
889738009251	Protein of unknown function (DUF1255); Region: DUF1255; pfam06865
889738009252	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
889738009253	binding surface
889738009254	Tetratricopeptide repeat; Region: TPR_16; pfam13432
889738009255	TPR motif; other site
889738009256	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497
889738009257	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
889738009258	Walker A/P-loop; other site
889738009259	ATP binding site [chemical binding]; other site
889738009260	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
889738009261	ABC transporter signature motif; other site
889738009262	Walker B; other site
889738009263	D-loop; other site
889738009264	H-loop/switch region; other site
889738009265	Uncharacterized ACR, COG1678; Region: DUF179; pfam02622
889738009266	Holliday junction resolvase-like protein; Reviewed; Region: PRK00109
889738009267	Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566
889738009268	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
889738009269	HlyD family secretion protein; Region: HlyD_3; pfam13437
889738009270	Protein of unknown function (DUF1656); Region: DUF1656; pfam07869
889738009271	Fusaric acid resistance protein family; Region: FUSC; pfam04632
889738009272	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
889738009273	IclR helix-turn-helix domain; Region: HTH_IclR; cl17605
889738009274	Transcriptional regulator [Transcription]; Region: IclR; COG1414
889738009275	Bacterial transcriptional regulator; Region: IclR; pfam01614
889738009276	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_2; pfam13532
889738009277	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
889738009278	Helix-turn-helix domain; Region: HTH_18; pfam12833
889738009279	Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350
889738009280	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
889738009281	DNA binding site [nucleotide binding]
889738009282	active site
889738009283	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453
889738009284	Thioesterase-like superfamily; Region: 4HBT_3; pfam13622
889738009285	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445
889738009286	active site
889738009287	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II; cd00556
889738009288	active site
889738009289	dimer interface [polypeptide binding]; other site
889738009290	excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558
889738009291	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
889738009292	GIY-YIG motif/motif A; other site
889738009293	active site
889738009294	catalytic site [active]
889738009295	putative DNA binding site [nucleotide binding]; other site
889738009296	metal binding site [ion binding]; metal-binding site
889738009297	UvrB/uvrC motif; Region: UVR; pfam02151
889738009298	UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459
889738009299	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220
889738009300	Aspartyl/asparaginyl beta-hydroxylase and related dioxygenases [Posttranslational modification, protein turnover, chaperones]; Region: COG3555
889738009301	multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadB; PRK11730
889738009302	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
889738009303	substrate binding site [chemical binding]; other site
889738009304	oxyanion hole (OAH) forming residues; other site
889738009305	trimer interface [polypeptide binding]; other site
889738009306	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
889738009307	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
889738009308	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
889738009309	3-ketoacyl-CoA thiolase; Reviewed; Region: fadA; PRK08947
889738009310	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
889738009311	dimer interface [polypeptide binding]; other site
889738009312	active site
889738009313	hypothetical protein; Provisional; Region: PRK10215
889738009314	Predicted esterase of the alpha/beta hydrolase fold [General function prediction only]; Region: COG3545
889738009315	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
889738009316	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
889738009317	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
889738009318	DNA binding residues [nucleotide binding]
889738009319	Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761
889738009320	DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024
889738009321	catalytic residues [active]
889738009322	heat shock protein 90; Provisional; Region: PRK05218
889738009323	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
889738009324	ATP binding site [chemical binding]; other site
889738009325	Mg2+ binding site [ion binding]; other site
889738009326	G-X-G motif; other site
889738009327	Protein of unknown function (DUF1311); Region: DUF1311; pfam07007
889738009328	Outer membrane protein W [Cell envelope biogenesis, outer membrane]; Region: OmpW; COG3047
889738009329	Predicted permease [General function prediction only]; Region: COG2056
889738009330	Na+-H+ antiporter family; Region: Na_H_antiport_2; pfam13726
889738009331	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
889738009332	Putative serine esterase (DUF676); Region: DUF676; pfam05057
889738009333	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
889738009334	active site 2 [active]
889738009335	active site 1 [active]
889738009336	RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997
889738009337	DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086
889738009338	RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663
889738009339	RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983
889738009340	RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000
889738009341	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
889738009342	Rpb1 - Rpb6 interaction site [polypeptide binding]; other site
889738009343	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
889738009344	Rpb1 - Rpb6 interaction site [polypeptide binding]; other site
889738009345	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
889738009346	DNA binding site [nucleotide binding]
889738009347	Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site
889738009348	DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405
889738009349	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585
889738009350	RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561
889738009351	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
889738009352	RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562
889738009353	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
889738009354	RPB1 interaction site [polypeptide binding]; other site
889738009355	RPB11 interaction site [polypeptide binding]; other site
889738009356	RPB10 interaction site [polypeptide binding]; other site
889738009357	RPB3 interaction site [polypeptide binding]; other site
889738009358	Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387
889738009359	core dimer interface [polypeptide binding]; other site
889738009360	peripheral dimer interface [polypeptide binding]; other site
889738009361	L10 interface [polypeptide binding]; other site
889738009362	L11 interface [polypeptide binding]; other site
889738009363	putative EF-Tu interaction site [polypeptide binding]; other site
889738009364	putative EF-G interaction site [polypeptide binding]; other site
889738009365	Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797
889738009366	23S rRNA interface [nucleotide binding]; other site
889738009367	Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site
889738009368	Ribosomal protein L1.  The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA.  In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403
889738009369	mRNA/rRNA interface [nucleotide binding]; other site
889738009370	50S ribosomal protein L11; Validated; Region: rplK; PRK00140
889738009371	Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349
889738009372	23S rRNA interface [nucleotide binding]; other site
889738009373	L7/L12 interface [polypeptide binding]; other site
889738009374	putative thiostrepton binding site; other site
889738009375	L25 interface [polypeptide binding]; other site
889738009376	transcription antitermination protein NusG; Validated; Region: nusG; PRK05609
889738009377	Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891
889738009378	putative homodimer interface [polypeptide binding]; other site
889738009379	NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091
889738009380	heterodimer interface [polypeptide binding]; other site
889738009381	homodimer interface [polypeptide binding]; other site
889738009382	preprotein translocase subunit SecE; Reviewed; Region: secE; PRK05740
889738009383	elongation factor Tu; Reviewed; Region: PRK00049
889738009384	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
889738009385	G1 box; other site
889738009386	GEF interaction site [polypeptide binding]; other site
889738009387	GTP/Mg2+ binding site [chemical binding]; other site
889738009388	Switch I region; other site
889738009389	G2 box; other site
889738009390	G3 box; other site
889738009391	Switch II region; other site
889738009392	G4 box; other site
889738009393	G5 box; other site
889738009394	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
889738009395	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
889738009396	Antibiotic Binding Site [chemical binding]; other site
889738009397	anthranilate synthase component I; Provisional; Region: PRK13565
889738009398	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
889738009399	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
889738009400	phosphoglycolate phosphatase; Provisional; Region: PRK13222
889738009401	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
889738009402	motif II; other site
889738009403	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
889738009404	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
889738009405	phosphopeptide binding site; other site
889738009406	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
889738009407	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
889738009408	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
889738009409	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
889738009410	type II secretion system protein C; Region: typeII_sec_gspC; TIGR01713
889738009411	Type IV pilus biogenesis; Region: Pilus_PilP; pfam11356
889738009412	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
889738009413	Type II secretion system (T2SS), protein N; Region: T2SN; pfam01203
889738009414	H-NS histone family; Region: Histone_HNS; pfam00816
889738009415	Domain in histone-like proteins of HNS family; Region: HNS; smart00528
889738009416	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
889738009417	active site
889738009418	heme biosynthesis-associated TPR protein; Region: TPR_hemY_coli; TIGR00540
889738009419	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
889738009420	Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587
889738009421	active site
889738009422	porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072
889738009423	Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494
889738009424	domain interfaces; other site
889738009425	active site
889738009426	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
889738009427	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
889738009428	active site
889738009429	phosphorylation site [posttranslational modification]
889738009430	intermolecular recognition site; other site
889738009431	dimerization interface [polypeptide binding]; other site
889738009432	LytTr DNA-binding domain; Region: LytTR; smart00850
889738009433	Histidine kinase; Region: His_kinase; pfam06580
889738009434	argininosuccinate lyase; Provisional; Region: PRK00855
889738009435	Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359
889738009436	active sites [active]
889738009437	tetramer interface [polypeptide binding]; other site
889738009438	oxidative damage protection protein; Provisional; Region: PRK05408
889738009439	transcriptional regulator PhoU; Provisional; Region: PRK11115
889738009440	PhoU domain; Region: PhoU; pfam01895
889738009441	PhoU domain; Region: PhoU; pfam01895
889738009442	type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844
889738009443	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
889738009444	EamA-like transporter family; Region: EamA; pfam00892
889738009445	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
889738009446	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
889738009447	thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284
889738009448	ThiC-associated domain; Region: ThiC-associated; pfam13667
889738009449	Thiamine biosynthesis protein ThiC [Coenzyme metabolism]; Region: ThiC; COG0422
889738009450	ADP-ribose pyrophosphatase NudF; Provisional; Region: nudF; PRK10729
889738009451	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
889738009452	dimer interface [polypeptide binding]; other site
889738009453	ADP-ribose binding site [chemical binding]; other site
889738009454	active site
889738009455	nudix motif; other site
889738009456	metal binding site [ion binding]; metal-binding site
889738009457	Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402
889738009458	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
889738009459	active site
889738009460	metal binding site [ion binding]; metal-binding site
889738009461	hexamer interface [polypeptide binding]; other site
889738009462	RNA polymerase-binding protein DksA; Region: dksA; TIGR02420
889738009463	glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710
889738009464	active site
889738009465	nucleotide binding site [chemical binding]; other site
889738009466	HIGH motif; other site
889738009467	KMSKS motif; other site
889738009468	cell division protein FtsW; Region: ftsW; TIGR02614
889738009469	UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK03803
889738009470	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
889738009471	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
889738009472	Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370
889738009473	Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879
889738009474	G1 box; other site
889738009475	GTP/Mg2+ binding site [chemical binding]; other site
889738009476	Switch I region; other site
889738009477	G2 box; other site
889738009478	G3 box; other site
889738009479	Switch II region; other site
889738009480	G4 box; other site
889738009481	G5 box; other site
889738009482	Nucleoside recognition; Region: Gate; pfam07670
889738009483	Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664
889738009484	Nucleoside recognition; Region: Gate; pfam07670
889738009485	FeoA domain; Region: FeoA; pfam04023
889738009486	site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283
889738009487	XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798
889738009488	active site
889738009489	Int/Topo IB signature motif; other site
889738009490	Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651
889738009491	DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020
889738009492	dimerization domain [polypeptide binding]; other site
889738009493	dimer interface [polypeptide binding]; other site
889738009494	catalytic residues [active]
889738009495	homoserine dehydrogenase; Provisional; Region: PRK06349
889738009496	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
889738009497	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
889738009498	ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881
889738009499	threonine synthase; Reviewed; Region: PRK06721
889738009500	Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of  threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563
889738009501	homodimer interface [polypeptide binding]; other site
889738009502	pyridoxal 5'-phosphate binding site [chemical binding]; other site
889738009503	catalytic residue [active]
889738009504	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
889738009505	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768
889738009506	response regulator; Provisional; Region: PRK09483
889738009507	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
889738009508	active site
889738009509	phosphorylation site [posttranslational modification]
889738009510	intermolecular recognition site; other site
889738009511	dimerization interface [polypeptide binding]; other site
889738009512	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
889738009513	DNA binding residues [nucleotide binding]
889738009514	dimerization interface [polypeptide binding]; other site
889738009515	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
889738009516	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
889738009517	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
889738009518	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
889738009519	dimer interface [polypeptide binding]; other site
889738009520	phosphorylation site [posttranslational modification]
889738009521	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
889738009522	ATP binding site [chemical binding]; other site
889738009523	Mg2+ binding site [ion binding]; other site
889738009524	G-X-G motif; other site
889738009525	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
889738009526	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
889738009527	active site
889738009528	phosphorylation site [posttranslational modification]
889738009529	intermolecular recognition site; other site
889738009530	dimerization interface [polypeptide binding]; other site
889738009531	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
889738009532	Walker A motif; other site
889738009533	ATP binding site [chemical binding]; other site
889738009534	Walker B motif; other site
889738009535	arginine finger; other site
889738009536	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
889738009537	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
889738009538	C-terminal peptidase (prc); Region: prc; TIGR00225
889738009539	PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cd00136
889738009540	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
889738009541	Catalytic dyad [active]
889738009542	phosphoglyceromutase; Provisional; Region: PRK05434
889738009543	Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696
889738009544	Predicted permeases [General function prediction only]; Region: COG0795; cl12074
889738009545	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
889738009546	Predicted permeases [General function prediction only]; Region: COG0795; cl12074
889738009547	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
889738009548	multifunctional aminopeptidase A; Provisional; Region: PRK00913
889738009549	Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433
889738009550	interface (dimer of trimers) [polypeptide binding]; other site
889738009551	Substrate-binding/catalytic site; other site
889738009552	Zn-binding sites [ion binding]; other site
889738009553	DNA polymerase III chi subunit, HolC; Region: DNA_pol3_chi; pfam04364
889738009554	riboflavin synthase subunit alpha; Provisional; Region: PRK09289
889738009555	Lumazine binding domain; Region: Lum_binding; pfam00677
889738009556	Lumazine binding domain; Region: Lum_binding; pfam00677
889738009557	Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG3392
889738009558	D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; cl17344
889738009559	bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase; Provisional; Region: ribD; PRK10786
889738009560	Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284
889738009561	catalytic motif [active]
889738009562	Zn binding site [ion binding]; other site
889738009563	RibD C-terminal domain; Region: RibD_C; cl17279
889738009564	transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464
889738009565	ATP cone domain; Region: ATP-cone; pfam03477
889738009566	Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004
889738009567	Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347
889738009568	Nitrogen regulatory protein P-II; Region: P-II; smart00938
889738009569	Membrane fusogenic activity; Region: BMFP; pfam04380
889738009570	Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606
889738009571	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
889738009572	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078
889738009573	Aminoglycoside 3'-phosphotransferase (APH). The APH subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin...; Region: APH; cd05150
889738009574	Phosphotransferase enzyme family; Region: APH; pfam01636
889738009575	active site
889738009576	ATP binding site [chemical binding]; other site
889738009577	antibiotic binding site [chemical binding]; other site
889738009578	Aminoglycoside/hydroxyurea antibiotic resistance kinase; Region: APH_6_hur; pfam04655
889738009579	Transposase zinc-binding domain; Region: Zn_Tnp_IS91; pfam14319
889738009580	Putative transposase; Region: Y2_Tnp; pfam04986
889738009581	tetracycline repressor protein TetR; Provisional; Region: PRK13756
889738009582	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
889738009583	Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909
889738009584	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
889738009585	Major Facilitator Superfamily; Region: MFS_1; pfam07690
889738009586	putative substrate translocation pore; other site
889738009587	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
889738009588	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
889738009589	Sulfate transporter family; Region: Sulfate_transp; pfam00916
889738009590	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
889738009591	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
889738009592	Ligand Binding Site [chemical binding]; other site
889738009593	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
889738009594	Ligand Binding Site [chemical binding]; other site
889738009595	formamidopyrimidine-DNA glycosylase; Provisional; Region: PRK14811
889738009596	Bacterial TniB protein; Region: TniB; pfam05621
889738009597	AAA domain; Region: AAA_22; pfam13401
889738009598	Helix-turn-helix domain; Region: HTH_28; pfam13518
889738009599	Integrase core domain; Region: rve; pfam00665
889738009600	Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299
889738009601	TnsA endonuclease N terminal; Region: Tn7_Tnp_TnsA_N; pfam08722
889738009602	The alpha-D-phosphohexomutase superfamily includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this family include the phosphoglucomutases (PGM1 and PGM2), phosphoglucosamine...; Region: phosphohexomutase; cl03757
889738009603	dihydropteroate synthase; Region: DHPS; TIGR01496
889738009604	DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
889738009605	substrate binding pocket [chemical binding]; other site
889738009606	dimer interface [polypeptide binding]; other site
889738009607	inhibitor binding site; inhibition site
889738009608	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
889738009609	Bacterial TniB protein; Region: TniB; pfam05621
889738009610	Helix-turn-helix domain; Region: HTH_28; pfam13518
889738009611	Integrase core domain; Region: rve; pfam00665
889738009612	TnsA endonuclease N terminal; Region: Tn7_Tnp_TnsA_N; pfam08722
889738009613	site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236
889738009614	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
889738009615	active site
889738009616	DNA binding site [nucleotide binding]
889738009617	Int/Topo IB signature motif; other site
889738009618	AAA domain; Region: AAA_33; pfam13671
889738009619	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4185
889738009620	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
889738009621	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
889738009622	Sulfate transporter family; Region: Sulfate_transp; pfam00916
889738009623	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
889738009624	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
889738009625	Ligand Binding Site [chemical binding]; other site
889738009626	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
889738009627	Ligand Binding Site [chemical binding]; other site
889738009628	Bacterial TniB protein; Region: TniB; pfam05621
889738009629	AAA domain; Region: AAA_22; pfam13401
889738009630	Helix-turn-helix domain; Region: HTH_28; pfam13518
889738009631	Integrase core domain; Region: rve; pfam00665
889738009632	Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299
889738009633	TnsA endonuclease N terminal; Region: Tn7_Tnp_TnsA_N; pfam08722
889738009634	Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606
889738009635	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078
889738009636	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335
889738009637	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
889738009638	DNA-binding site [nucleotide binding]; DNA binding site
889738009639	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
889738009640	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
889738009641	pyridoxal 5'-phosphate binding site [chemical binding]; other site
889738009642	homodimer interface [polypeptide binding]; other site
889738009643	catalytic residue [active]
889738009644	class II aldolase/adducin domain protein; Provisional; Region: PRK07090
889738009645	intersubunit interface [polypeptide binding]; other site
889738009646	active site
889738009647	Zn2+ binding site [ion binding]; other site
889738009648	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
889738009649	Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408
889738009650	inhibitor site; inhibition site
889738009651	active site
889738009652	dimer interface [polypeptide binding]; other site
889738009653	catalytic residue [active]
889738009654	Bacterial protein of unknown function (Gcw_chp); Region: Gcw_chp; cl09901
889738009655	outer membrane porin, OprD family; Region: OprD; pfam03573
889738009656	Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412
889738009657	dimer interface [polypeptide binding]; other site
889738009658	substrate binding site [chemical binding]; other site
889738009659	metal binding sites [ion binding]; metal-binding site
889738009660	MAPEG family; Region: MAPEG; cl09190
889738009661	Long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07059
889738009662	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
889738009663	Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936
889738009664	acyl-activating enzyme (AAE) consensus motif; other site
889738009665	putative AMP binding site [chemical binding]; other site
889738009666	putative active site [active]
889738009667	putative CoA binding site [chemical binding]; other site
889738009668	DNA topoisomerase IV subunit A; Validated; Region: PRK05561
889738009669	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
889738009670	CAP-like domain; other site
889738009671	active site
889738009672	primary dimer interface [polypeptide binding]; other site
889738009673	benzoate transport; Region: 2A0115; TIGR00895
889738009674	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
889738009675	putative substrate translocation pore; other site
889738009676	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
889738009677	Predicted membrane protein [Function unknown]; Region: COG2860
889738009678	UPF0126 domain; Region: UPF0126; pfam03458
889738009679	UPF0126 domain; Region: UPF0126; pfam03458
889738009680	hypothetical protein; Provisional; Region: PRK01752
889738009681	SEC-C motif; Region: SEC-C; pfam02810
889738009682	Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861
889738009683	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
889738009684	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
889738009685	Transporter associated domain; Region: CorC_HlyC; smart01091
889738009686	Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695
889738009687	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
889738009688	putative transporter; Provisional; Region: PRK10504
889738009689	putative substrate translocation pore; other site
889738009690	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
889738009691	Uncharacterized bacterial muramidase containing a glycosyl hydrolase family 25 (GH25) catalytic domain. Endo-N-acetylmuramidases are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis...; Region: GH25_muramidase_1; cd06413
889738009692	active site
889738009693	Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183
889738009694	DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586
889738009695	active site
889738009696	DNA polymerase IV; Validated; Region: PRK02406
889738009697	DNA binding site [nucleotide binding]
889738009698	This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function.  The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150
889738009699	homotrimer interaction site [polypeptide binding]; other site
889738009700	putative active site [active]
889738009701	Protein of unknown function (DUF2726); Region: DUF2726; pfam10881
889738009702	hypothetical protein; Provisional; Region: PRK01254
889738009703	Radical SAM N-terminal; Region: Radical_SAM_N; pfam08497
889738009704	Radical SAM N-terminal; Region: Radical_SAM_N; pfam08497
889738009705	Domain of unknown function (DUF3362); Region: DUF3362; pfam11842
889738009706	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4222
889738009707	Class II Chelatase: a family of ATP-independent monomeric or homodimeric enzymes that catalyze the insertion of metal into protoporphyrin rings. This family includes protoporphyrin IX ferrochelatase (HemH), sirohydrochlorin ferrochelatase (SirB) and the...; Region: Chelatase_Class_II; cl02784
889738009708	Cu(I)-responsive transcriptional regulator; Region: CueR; TIGR02044
889738009709	Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg6; cd04781
889738009710	DNA binding residues [nucleotide binding]
889738009711	putative dimer interface [polypeptide binding]; other site
889738009712	putative metal binding residues [ion binding]; other site
889738009713	Protein of unknown function (DUF2938); Region: DUF2938; pfam11158
889738009714	Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655
889738009715	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
889738009716	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
889738009717	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
889738009718	N-acetyl-D-glucosamine binding site [chemical binding]; other site
889738009719	catalytic residue [active]
889738009720	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
889738009721	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
889738009722	dimer interface [polypeptide binding]; other site
889738009723	pyridoxal 5'-phosphate binding site [chemical binding]; other site
889738009724	catalytic residue [active]
889738009725	Acetyltransferase (GNAT) domain; Region: Acetyltransf_9; pfam13527
889738009726	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
889738009727	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
889738009728	Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; pfam09995
889738009729	TonB-dependent copper receptor; Region: TonB-copper; TIGR01778
889738009730	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
889738009731	N-terminal plug; other site
889738009732	ligand-binding site [chemical binding]; other site
889738009733	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
889738009734	active site
889738009735	catalytic residues [active]
889738009736	metal binding site [ion binding]; metal-binding site
889738009737	Uncharacterized protein containing LysM domain [Function unknown]; Region: XkdP; COG1652
889738009738	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
889738009739	DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481
889738009740	DNA protecting protein DprA; Region: dprA; TIGR00732
889738009741	Telomere recombination; Region: Sua5_yciO_yrdC; cl00305
889738009742	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
889738009743	EamA-like transporter family; Region: EamA; pfam00892
889738009744	EamA-like transporter family; Region: EamA; pfam00892
889738009745	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
889738009746	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
889738009747	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
889738009748	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
889738009749	putative substrate translocation pore; other site
889738009750	Helix-turn-helix domain; Region: HTH_18; pfam12833
889738009751	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
889738009752	Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340
889738009753	catalytic residues [active]
889738009754	dimer interface [polypeptide binding]; other site
889738009755	F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571
889738009756	mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152
889738009757	gamma subunit interface [polypeptide binding]; other site
889738009758	epsilon subunit interface [polypeptide binding]; other site
889738009759	LBP interface [polypeptide binding]; other site
889738009760	F0F1 ATP synthase subunit beta; Validated; Region: PRK09280
889738009761	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
889738009762	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
889738009763	alpha subunit interaction interface [polypeptide binding]; other site
889738009764	Walker A motif; other site
889738009765	ATP binding site [chemical binding]; other site
889738009766	Walker B motif; other site
889738009767	inhibitor binding site; inhibition site
889738009768	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
889738009769	mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151
889738009770	core domain interface [polypeptide binding]; other site
889738009771	delta subunit interface [polypeptide binding]; other site
889738009772	epsilon subunit interface [polypeptide binding]; other site
889738009773	F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281
889738009774	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
889738009775	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
889738009776	Walker A motif; other site
889738009777	ATP binding site [chemical binding]; other site
889738009778	Walker B motif; other site
889738009779	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
889738009780	F0F1 ATP synthase subunit delta; Validated; Region: PRK05758
889738009781	ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213
889738009782	F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711
889738009783	F0F1 ATP synthase subunit B; Validated; Region: PRK05759
889738009784	F0F1 ATP synthase subunit C; Validated; Region: PRK06876
889738009785	F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356
889738009786	F0F1 ATP synthase subunit A; Validated; Region: PRK05815
889738009787	F0F1 ATP synthase subunit I; Validated; Region: PRK05760
889738009788	Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297
889738009789	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
889738009790	intersubunit interface [polypeptide binding]; other site
889738009791	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cl17326
889738009792	metal binding site 2 [ion binding]; metal-binding site
889738009793	putative DNA binding helix; other site
889738009794	metal binding site 1 [ion binding]; metal-binding site
889738009795	dimer interface [polypeptide binding]; other site
889738009796	structural Zn2+ binding site [ion binding]; other site
889738009797	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
889738009798	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
889738009799	Walker A/P-loop; other site
889738009800	ATP binding site [chemical binding]; other site
889738009801	Q-loop/lid; other site
889738009802	ABC transporter signature motif; other site
889738009803	Walker B; other site
889738009804	D-loop; other site
889738009805	H-loop/switch region; other site
889738009806	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
889738009807	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
889738009808	ABC-ATPase subunit  interface; other site
889738009809	dimer interface [polypeptide binding]; other site
889738009810	putative PBP binding regions; other site
889738009811	LysE type translocator; Region: LysE; cl00565
889738009812	Dyp-type peroxidase family; Region: Dyp_perox; cl01067
889738009813	malate dehydrogenase; Provisional; Region: PRK13529
889738009814	Malic enzyme, N-terminal domain; Region: malic; pfam00390
889738009815	NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312
889738009816	NAD(P) binding site [chemical binding]; other site
889738009817	Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016
889738009818	Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018
889738009819	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
889738009820	active site
889738009821	HIGH motif; other site
889738009822	nucleotide binding site [chemical binding]; other site
889738009823	catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
889738009824	KMSK motif region; other site
889738009825	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
889738009826	tRNA binding surface [nucleotide binding]; other site
889738009827	anticodon binding site; other site
889738009828	Sporulation related domain; Region: SPOR; pfam05036
889738009829	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
889738009830	GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046
889738009831	putative C-terminal domain interface [polypeptide binding]; other site
889738009832	putative GSH binding site (G-site) [chemical binding]; other site
889738009833	putative dimer interface [polypeptide binding]; other site
889738009834	C-terminal, alpha helical domain of GTT1-like Glutathione S-transferases; Region: GST_C_GTT1_like; cd03189
889738009835	putative N-terminal domain interface [polypeptide binding]; other site
889738009836	putative dimer interface [polypeptide binding]; other site
889738009837	putative substrate binding pocket (H-site) [chemical binding]; other site
889738009838	OsmC-like protein; Region: OsmC; pfam02566
889738009839	Pirin; Region: Pirin; pfam02678
889738009840	Pirin-related protein [General function prediction only]; Region: COG1741
889738009841	Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726
889738009842	Domain of Unknown Function with PDB structure (DUF3861); Region: DUF3861; pfam12977
889738009843	Predicted transcriptional regulators [Transcription]; Region: COG1695
889738009844	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
889738009845	aminoglycoside resistance protein; Provisional; Region: PRK13746
889738009846	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
889738009847	active site
889738009848	NTP binding site [chemical binding]; other site
889738009849	metal binding triad [ion binding]; metal-binding site
889738009850	antibiotic binding site [chemical binding]; other site
889738009851	Domain of unknown function (DUF4111); Region: DUF4111; pfam13427
889738009852	GMP synthase; Reviewed; Region: guaA; PRK00074
889738009853	Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742
889738009854	AMP/PPi binding site [chemical binding]; other site
889738009855	candidate oxyanion hole; other site
889738009856	catalytic triad [active]
889738009857	potential glutamine specificity residues [chemical binding]; other site
889738009858	The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997
889738009859	ATP Binding subdomain [chemical binding]; other site
889738009860	Ligand Binding sites [chemical binding]; other site
889738009861	Dimerization subdomain; other site
889738009862	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399
889738009863	Predicted membrane protein [Function unknown]; Region: COG2259
889738009864	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
889738009865	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
889738009866	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
889738009867	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
889738009868	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
889738009869	P-loop; other site
889738009870	Magnesium ion binding site [ion binding]; other site
889738009871	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
889738009872	Magnesium ion binding site [ion binding]; other site
889738009873	Invasion gene expression up-regulator, SirB; Region: SirB; cl01184
889738009874	Stress-induced morphogen (activity unknown) [Signal transduction mechanisms]; Region: BolA; COG0271
889738009875	Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091
889738009876	4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648
889738009877	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
889738009878	NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370
889738009879	NAD(P) binding site [chemical binding]; other site
889738009880	active site
889738009881	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
889738009882	Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303
889738009883	catalytic site [active]
889738009884	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
889738009885	hydrophobic ligand binding site; other site
889738009886	Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033
889738009887	Protein of unknown function (DUF1329); Region: DUF1329; pfam07044
889738009888	Condensation domain; Region: Condensation; pfam00668
889738009889	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
889738009890	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
889738009891	The adenylation domain of nonribosomal peptide synthetases (NRPS), including salinosporamide A polyketide synthase; Region: A_NRPS_Ta1_like; cd12116
889738009892	acyl-activating enzyme (AAE) consensus motif; other site
889738009893	AMP binding site [chemical binding]; other site
889738009894	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
889738009895	Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319
889738009896	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
889738009897	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
889738009898	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
889738009899	active site
889738009900	acyl-CoA synthetase; Validated; Region: PRK05850
889738009901	Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931
889738009902	acyl-activating enzyme (AAE) consensus motif; other site
889738009903	active site
889738009904	DNA-binding transcriptional activator SdiA; Provisional; Region: PRK10188
889738009905	Autoinducer binding domain; Region: Autoind_bind; pfam03472
889738009906	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
889738009907	DNA binding residues [nucleotide binding]
889738009908	dimerization interface [polypeptide binding]; other site
889738009909	Autoinducer synthetase; Region: Autoind_synth; cl17404
889738009910	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
889738009911	MarR family; Region: MarR_2; cl17246
889738009912	Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717
889738009913	substrate binding site [chemical binding]; other site
889738009914	active site
889738009915	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
889738009916	ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163
889738009917	substrate binding site [chemical binding]; other site
889738009918	hexamer interface [polypeptide binding]; other site
889738009919	metal binding site [ion binding]; metal-binding site
889738009920	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
889738009921	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
889738009922	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
889738009923	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
889738009924	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
889738009925	acyl-activating enzyme (AAE) consensus motif; other site
889738009926	acyl-activating enzyme (AAE) consensus motif; other site
889738009927	AMP binding site [chemical binding]; other site
889738009928	active site
889738009929	CoA binding site [chemical binding]; other site
889738009930	Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019
889738009931	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Btrk Decarboxylase; Region: PLPDE_III_Btrk_like; cd06839
889738009932	dimer interface [polypeptide binding]; other site
889738009933	active site
889738009934	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
889738009935	catalytic residues [active]
889738009936	substrate binding site [chemical binding]; other site
889738009937	Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236
889738009938	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
889738009939	metabolite-proton symporter; Region: 2A0106; TIGR00883
889738009940	putative substrate translocation pore; other site
889738009941	3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617
889738009942	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
889738009943	substrate binding site [chemical binding]; other site
889738009944	oxyanion hole (OAH) forming residues; other site
889738009945	trimer interface [polypeptide binding]; other site
889738009946	2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766
889738009947	enoyl-CoA hydratase; Provisional; Region: PRK05862
889738009948	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
889738009949	substrate binding site [chemical binding]; other site
889738009950	oxyanion hole (OAH) forming residues; other site
889738009951	trimer interface [polypeptide binding]; other site
889738009952	RNA recognition motif (RRM) superfamily; Region: RRM_SF; cl17169
889738009953	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
889738009954	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
889738009955	active site
889738009956	Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365
889738009957	Domain of unknown function (DUF3448); Region: DUF3448; pfam11930
889738009958	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
889738009959	acyl-activating enzyme (AAE) consensus motif; other site
889738009960	AMP binding site [chemical binding]; other site
889738009961	active site
889738009962	CoA binding site [chemical binding]; other site
889738009963	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
889738009964	3-hydroxyisobutyrate dehydrogenase; Region: HIBADH; TIGR01692
889738009965	Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085
889738009966	methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722
889738009967	tetrameric interface [polypeptide binding]; other site
889738009968	NAD binding site [chemical binding]; other site
889738009969	catalytic residues [active]
889738009970	Transcriptional regulator [Transcription]; Region: LysR; COG0583
889738009971	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
889738009972	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
889738009973	dimerization interface [polypeptide binding]; other site
889738009974	D-alanine/D-serine/glycine permease; Provisional; Region: PRK11049
889738009975	D-alanine/D-serine/glycine permease; Provisional; Region: PRK11049
889738009976	This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function.  The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150
889738009977	homotrimer interaction site [polypeptide binding]; other site
889738009978	putative active site [active]
889738009979	alanine racemase; Reviewed; Region: dadX; PRK03646
889738009980	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827
889738009981	active site
889738009982	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
889738009983	substrate binding site [chemical binding]; other site
889738009984	catalytic residues [active]
889738009985	dimer interface [polypeptide binding]; other site
889738009986	D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711
889738009987	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
889738009988	mRNA stabilisation; Region: mRNA_stabil; pfam13929
889738009989	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
889738009990	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
889738009991	putative DNA binding site [nucleotide binding]; other site
889738009992	putative Zn2+ binding site [ion binding]; other site
889738009993	AsnC family; Region: AsnC_trans_reg; pfam01037
889738009994	Predicted membrane protein [Function unknown]; Region: COG3503
889738009995	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
889738009996	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
889738009997	N-terminal plug; other site
889738009998	ligand-binding site [chemical binding]; other site
889738009999	SnoaL-like domain; Region: SnoaL_2; pfam12680
889738010000	Protein of unknown function (DUF1260); Region: DUF1260; pfam06877
889738010001	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
889738010002	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
889738010003	active site
889738010004	Predicted membrane protein [Function unknown]; Region: COG4420
889738010005	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
889738010006	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
889738010007	putative substrate translocation pore; other site
889738010008	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
889738010009	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
889738010010	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
889738010011	NAD(P) binding site [chemical binding]; other site
889738010012	active site
889738010013	Uncharacterized protein conserved in bacteria [Function unknown]; Region: VgrG; COG3501
889738010014	Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954
889738010015	Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717
889738010016	Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296
889738010017	Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; pfam10106
889738010018	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
889738010019	Sel1-like repeats; Region: SEL1; smart00671
889738010020	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
889738010021	binding surface
889738010022	TPR motif; other site
889738010023	Sel1-like repeats; Region: SEL1; smart00671
889738010024	Domain of unknown function (DUF4126); Region: DUF4126; pfam13548
889738010025	2-methylisocitrate dehydratase, Fe/S-dependent; Region: 2met_isocit_dHY; TIGR02333
889738010026	Aconitase A catalytic domain; Region: AcnA_IRP; cd01586
889738010027	substrate binding site [chemical binding]; other site
889738010028	ligand binding site [chemical binding]; other site
889738010029	Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215
889738010030	substrate binding site [chemical binding]; other site
889738010031	Citrate synthase [Energy production and conversion]; Region: GltA; COG0372
889738010032	methylcitrate synthase; Provisional; Region: PRK12351
889738010033	oxalacetate binding site [chemical binding]; other site
889738010034	citrylCoA binding site [chemical binding]; other site
889738010035	coenzyme A binding site [chemical binding]; other site
889738010036	catalytic triad [active]
889738010037	Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714
889738010038	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
889738010039	tetramer interface [polypeptide binding]; other site
889738010040	active site
889738010041	Mg2+/Mn2+ binding site [ion binding]; other site
889738010042	Transcriptional regulators [Transcription]; Region: GntR; COG1802
889738010043	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
889738010044	DNA-binding site [nucleotide binding]; DNA binding site
889738010045	FCD domain; Region: FCD; pfam07729
889738010046	aromatic amino acid aminotransferase; Provisional; Region: PRK09257
889738010047	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
889738010048	pyridoxal 5'-phosphate binding site [chemical binding]; other site
889738010049	homodimer interface [polypeptide binding]; other site
889738010050	catalytic residue [active]
889738010051	D-lactate dehydrogenase; Provisional; Region: PRK11183
889738010052	FAD binding domain; Region: FAD_binding_4; pfam01565
889738010053	D-lactate dehydrogenase, membrane binding; Region: Lact-deh-memb; pfam09330
889738010054	L-lactate dehydrogenase; Provisional; Region: lldD; PRK11197
889738010055	Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809
889738010056	active site
889738010057	substrate binding site [chemical binding]; other site
889738010058	FMN binding site [chemical binding]; other site
889738010059	putative catalytic residues [active]
889738010060	DNA-binding transcriptional repressor LldR; Provisional; Region: PRK10421
889738010061	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
889738010062	DNA-binding site [nucleotide binding]; DNA binding site
889738010063	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
889738010064	L-lactate permease; Provisional; Region: PRK10420
889738010065	glycolate transporter; Provisional; Region: PRK09695
889738010066	phosphomannomutase CpsG; Provisional; Region: PRK15414
889738010067	The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089
889738010068	active site
889738010069	substrate binding site [chemical binding]; other site
889738010070	metal binding site [ion binding]; metal-binding site
889738010071	UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247
889738010072	UDP-glucose 4-epimerase; Region: PLN02240
889738010073	NAD binding site [chemical binding]; other site
889738010074	homodimer interface [polypeptide binding]; other site
889738010075	active site
889738010076	substrate binding site [chemical binding]; other site
889738010077	glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179
889738010078	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015
889738010079	active site
889738010080	dimer interface [polypeptide binding]; other site
889738010081	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016
889738010082	dimer interface [polypeptide binding]; other site
889738010083	active site
889738010084	Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004
889738010085	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
889738010086	UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984
889738010087	Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541
889738010088	dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209
889738010089	active site
889738010090	tetramer interface; other site
889738010091	Bacterial sugar transferase; Region: Bac_transf; pfam02397
889738010092	UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472
889738010093	The members of this subfamily catalyze the formation of a phosphodiester bond between a membrane-associated undecaprenyl-phosphate (Und-P) molecule and N-acetylhexosamine 1-phosphate, which is usually donated by a soluble UDP-N-acetylhexosamine precursor; Region: GT_WbpL_WbcO_like; cd06854
889738010094	Mg++ binding site [ion binding]; other site
889738010095	putative catalytic motif [active]
889738010096	putative substrate binding site [chemical binding]; other site
889738010097	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
889738010098	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
889738010099	NAD(P) binding site [chemical binding]; other site
889738010100	active site
889738010101	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
889738010102	This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen.  It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794
889738010103	UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381
889738010104	Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase  family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786
889738010105	active site
889738010106	homodimer interface [polypeptide binding]; other site
889738010107	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
889738010108	NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370
889738010109	NAD(P) binding site [chemical binding]; other site
889738010110	active site
889738010111	dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfbC; COG1898
889738010112	UDP-N-acetylglucosamine 4,6-dehydratase/5-epimerase; Region: FnlA; TIGR04130
889738010113	UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237
889738010114	NAD(P) binding site [chemical binding]; other site
889738010115	homodimer interface [polypeptide binding]; other site
889738010116	substrate binding site [chemical binding]; other site
889738010117	active site
889738010118	Polysaccharide biosynthesis protein C-terminal; Region: Polysacc_syn_2C; pfam08485
889738010119	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
889738010120	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
889738010121	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
889738010122	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
889738010123	Vi polysaccharide biosynthesis protein TviC; Provisional; Region: PRK15181
889738010124	UDP-N-acetylglucosamine 4-epimerase, extended (e) SDRs; Region: UDP_AE_SDR_e; cd05256
889738010125	NAD binding site [chemical binding]; other site
889738010126	substrate binding site [chemical binding]; other site
889738010127	homodimer interface [polypeptide binding]; other site
889738010128	active site
889738010129	Vi polysaccharide biosynthesis protein TviB; Provisional; Region: PRK15182
889738010130	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
889738010131	UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984
889738010132	Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563
889738010133	polysaccharide export protein EpsE; Region: EpsE; TIGR03028
889738010134	Low molecular weight phosphatase family; Region: LMWPc; cd00115
889738010135	Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451
889738010136	active site
889738010137	tyrosine kinase; Provisional; Region: PRK11519
889738010138	Chain length determinant protein; Region: Wzz; pfam02706
889738010139	G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807
889738010140	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
889738010141	Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346
889738010142	FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545
889738010143	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
889738010144	Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346
889738010145	FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545
889738010146	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
889738010147	Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728
889738010148	MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123
889738010149	N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023
889738010150	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
889738010151	amidase catalytic site [active]
889738010152	Zn binding residues [ion binding]; other site
889738010153	substrate binding site [chemical binding]; other site
889738010154	quinolinate phosphoribosyltransferase; Validated; Region: PRK09016
889738010155	Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572
889738010156	dimerization interface [polypeptide binding]; other site
889738010157	active site
889738010158	phospholipase C, phosphocholine-specific, Pseudomonas-type; Region: PC_PLC; TIGR03396
889738010159	Phosphoesterase family; Region: Phosphoesterase; pfam04185
889738010160	Domain of unknown function (DUF756); Region: DUF756; pfam05506
889738010161	Domain of unknown function (DUF756); Region: DUF756; pfam05506
889738010162	ribonuclease PH; Reviewed; Region: rph; PRK00173
889738010163	Ribonuclease PH; Region: RNase_PH_bact; cd11362
889738010164	hexamer interface [polypeptide binding]; other site
889738010165	active site
889738010166	Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239
889738010167	The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506
889738010168	putative di-iron ligands [ion binding]; other site
889738010169	Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_2; cd06216
889738010170	FMN reductase; Validated; Region: fre; PRK08051
889738010171	FAD binding pocket [chemical binding]; other site
889738010172	FAD binding motif [chemical binding]; other site
889738010173	phosphate binding motif [ion binding]; other site
889738010174	beta-alpha-beta structure motif; other site
889738010175	NAD binding pocket [chemical binding]; other site
889738010176	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
889738010177	catalytic loop [active]
889738010178	iron binding site [ion binding]; other site
889738010179	DNA-binding transcriptional repressor FabR; Provisional; Region: PRK11202
889738010180	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
889738010181	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
889738010182	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
889738010183	DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019
889738010184	catalytic residues [active]
889738010185	hinge region; other site
889738010186	alpha helical domain; other site
889738010187	bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134
889738010188	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
889738010189	S-adenosylmethionine binding site [chemical binding]; other site
889738010190	phosphoglycolate phosphatase; Provisional; Region: PRK13222
889738010191	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
889738010192	active site
889738010193	motif I; other site
889738010194	motif II; other site
889738010195	putative oxoacyl-(acyl carrier protein) reductase; Provisional; Region: PRK08945
889738010196	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
889738010197	NAD(P) binding site [chemical binding]; other site
889738010198	active site
889738010199	Domain of unknown function (DUF3315); Region: DUF3315; pfam11776
889738010200	Domain of unknown function (DUF3315); Region: DUF3315; pfam11776
889738010201	N-acetylglutamate synthase; Validated; Region: PRK05279
889738010202	AAK_NAGS-ABP: N-acetylglutamate (NAG) kinase-like domain of the NAG Synthase (NAGS) of the arginine-biosynthesis pathway (ABP) found in gamma- and beta-proteobacteria and higher plant chloroplasts. Domain architecture of these NAGS consisted of an...; Region: AAK_NAGS-ABP; cd04237
889738010203	putative feedback inhibition sensing region; other site
889738010204	putative nucleotide binding site [chemical binding]; other site
889738010205	putative substrate binding site [chemical binding]; other site
889738010206	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
889738010207	Coenzyme A binding pocket [chemical binding]; other site
889738010208	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
889738010209	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
889738010210	substrate binding pocket [chemical binding]; other site
889738010211	membrane-bound complex binding site; other site
889738010212	hinge residues; other site
889738010213	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
889738010214	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
889738010215	substrate binding pocket [chemical binding]; other site
889738010216	membrane-bound complex binding site; other site
889738010217	hinge residues; other site
889738010218	alkanesulfonate monooxygenase; Provisional; Region: PRK00719
889738010219	Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094
889738010220	active site
889738010221	dimer interface [polypeptide binding]; other site
889738010222	non-prolyl cis peptide bond; other site
889738010223	insertion regions; other site
889738010224	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
889738010225	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
889738010226	putative PBP binding loops; other site
889738010227	dimer interface [polypeptide binding]; other site
889738010228	ABC-ATPase subunit interface; other site
889738010229	aliphatic sulfonates transport ATP-binding subunit; Provisional; Region: ssuB; PRK11247
889738010230	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
889738010231	Walker A/P-loop; other site
889738010232	ATP binding site [chemical binding]; other site
889738010233	Q-loop/lid; other site
889738010234	ABC transporter signature motif; other site
889738010235	Walker B; other site
889738010236	D-loop; other site
889738010237	H-loop/switch region; other site
889738010238	pyrimidine utilization regulatory protein R; Region: RutR; TIGR03613
889738010239	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
889738010240	YcdC-like protein, C-terminal region; Region: TetR_C_3; pfam08362
889738010241	Phosphorylase superfamily; Region: PNP_UDP_1; cl00303
889738010242	Tellurite resistance protein and related permeases [Inorganic ion transport and metabolism]; Region: TehA; COG1275
889738010243	Tellurite-resistance/Dicarboxylate Transporter (TDT) family includes sulfite sensitivity protein (sulfite efflux pump; SSU1); Region: TDT_SSU1; cd09318
889738010244	gating phenylalanine in ion channel; other site
889738010245	bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627
889738010246	FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064
889738010247	active site
889738010248	Riboflavin kinase; Region: Flavokinase; smart00904
889738010249	isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743
889738010250	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
889738010251	active site
889738010252	HIGH motif; other site
889738010253	nucleotide binding site [chemical binding]; other site
889738010254	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
889738010255	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
889738010256	active site
889738010257	KMSKS motif; other site
889738010258	Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960
889738010259	tRNA binding surface [nucleotide binding]; other site
889738010260	anticodon binding site; other site
889738010261	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
889738010262	lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376
889738010263	FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095
889738010264	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
889738010265	Predicted flavoprotein [General function prediction only]; Region: COG0431
889738010266	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
889738010267	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
889738010268	Ankyrin repeats (many copies); Region: Ank_4; pfam13637
889738010269	Ankyrin repeats (many copies); Region: Ank_4; pfam13637
889738010270	peptidyl-prolyl cis-trans isomerase A (rotamase A); Provisional; Region: PRK10903
889738010271	cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920
889738010272	substrate binding site [chemical binding]; other site
889738010273	Protein of unknown function (DUF2424); Region: DUF2424; pfam10340
889738010274	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
889738010275	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
889738010276	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
889738010277	Transcriptional regulator [Transcription]; Region: LysR; COG0583
889738010278	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
889738010279	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
889738010280	putative effector binding pocket; other site
889738010281	dimerization interface [polypeptide binding]; other site
889738010282	GrpE; Region: GrpE; pfam01025
889738010283	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
889738010284	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
889738010285	dimer interface [polypeptide binding]; other site
889738010286	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
889738010287	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
889738010288	nucleotide binding site [chemical binding]; other site
889738010289	Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064
889738010290	active site
889738010291	Dual-action HEIGH metallo-peptidase; Region: Peptidase_M57; pfam12388
889738010292	Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064
889738010293	active site
889738010294	Transglycosylase SLT domain; Region: SLT_2; pfam13406
889738010295	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
889738010296	N-acetyl-D-glucosamine binding site [chemical binding]; other site
889738010297	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
889738010298	phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019
889738010299	ATP-grasp domain; Region: ATP-grasp; pfam02222
889738010300	AIR carboxylase; Region: AIRC; pfam00731
889738010301	Protein of unknown function, DUF486; Region: DUF486; cl01236
889738010302	UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase; Region: mpl; TIGR01081
889738010303	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
889738010304	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
889738010305	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
889738010306	Bacterial low temperature requirement A protein (LtrA); Region: LtrA; cl01754
889738010307	PAP2_like proteins, BcrC_like subfamily. Several members of this family have been annotated as bacitracin transport permeases, as it was suspected that they form the permease component of an ABC transporter system. It was shown, however, that BcrC from...; Region: PAP2_BcrC_like; cd03385
889738010308	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
889738010309	active site
889738010310	integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718
889738010311	Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754
889738010312	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
889738010313	Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469
889738010314	[2Fe-2S] cluster binding site [ion binding]; other site
889738010315	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
889738010316	hydrophobic ligand binding site; other site
889738010317	guanine deaminase; Provisional; Region: PRK09228
889738010318	Guanine deaminase (GDEase). Guanine deaminase is an aminohydrolase responsible for the conversion of guanine to xanthine and ammonia, the first step to utilize guanine as a nitrogen source. This reaction also removes the guanine base from the pool and...; Region: GDEase; cd01303
889738010319	active site
889738010320	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
889738010321	active site
889738010322	Predicted membrane protein [Function unknown]; Region: COG2261
889738010323	Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651
889738010324	DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020
889738010325	dimerization domain [polypeptide binding]; other site
889738010326	dimer interface [polypeptide binding]; other site
889738010327	catalytic residues [active]
889738010328	Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230
889738010329	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
889738010330	Transcriptional regulators RcnR and FrmR, and related domains; this domain family was previously known as part of DUF156; Region: RcnR-FrmR-like_DUF156; cd10153
889738010331	putative metal binding site [ion binding]; other site
889738010332	putative homodimer interface [polypeptide binding]; other site
889738010333	putative homotetramer interface [polypeptide binding]; other site
889738010334	putative homodimer-homodimer interface [polypeptide binding]; other site
889738010335	putative allosteric switch controlling residues; other site
889738010336	tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291
889738010337	GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396
889738010338	trmE is a tRNA modification GTPase; Region: trmE; cd04164
889738010339	G1 box; other site
889738010340	GTP/Mg2+ binding site [chemical binding]; other site
889738010341	Switch I region; other site
889738010342	G2 box; other site
889738010343	Switch II region; other site
889738010344	G3 box; other site
889738010345	G4 box; other site
889738010346	G5 box; other site
889738010347	Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631
889738010348	membrane protein insertase; Provisional; Region: PRK01318
889738010349	membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592
889738010350	hypothetical protein; Provisional; Region: PRK14386
889738010351	Ribonuclease P; Region: Ribonuclease_P; pfam00825
889738010352	50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399
889738010353	Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286
889738010354	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
889738010355	Active Sites [active]
889738010356	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
889738010357	Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270
889738010358	cofactor binding site; other site
889738010359	DNA binding site [nucleotide binding]
889738010360	substrate interaction site [chemical binding]; other site
889738010361	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
889738010362	H-NS histone family; Region: Histone_HNS; pfam00816
889738010363	Domain in histone-like proteins of HNS family; Region: HNS; smart00528
889738010364	Staphylococcal nuclease homologue; Region: SNase; pfam00565
889738010365	Catalytic site; other site
889738010366	Protein of unknown function (DUF1173); Region: DUF1173; pfam06666
889738010367	potential frameshift: common BLAST hit: gi|384133754|ref|YP_005516356.1| Zeta toxin family protein
889738010368	Zeta toxin; Region: Zeta_toxin; pfam06414
889738010369	Replicase family; Region: Replicase; pfam03090
889738010370	Primase C terminal 1 (PriCT-1); Region: PriCT_1; pfam08708
889738010371	Helix-turn-helix domain; Region: HTH_28; pfam13518
889738010372	Winged helix-turn helix; Region: HTH_29; pfam13551
889738010373	Abi-like protein; Region: Abi_2; pfam07751
889738010374	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
889738010375	TraG-like protein, N-terminal region; Region: TraG_N; pfam07916
889738010376	AmiS/UreI family transporter; Region: AmiS_UreI; pfam02293
889738010377	Conjugative relaxosome accessory transposon protein; Region: TraH; pfam06122
889738010378	F plasmid transfer operon protein; Region: TraF; pfam13728
889738010379	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
889738010380	catalytic residues [active]
889738010381	conjugal transfer mating pair stabilization protein TraN; Reviewed; Region: PRK12355
889738010382	Type-1V conjugative transfer system mating pair stabilisation; Region: TraN; pfam06986
889738010383	Type-F conjugative transfer system pilin assembly protein; Region: TrbC_Ftype; pfam09673
889738010384	TraU protein; Region: TraU; pfam06834
889738010385	Sex factor F TraW protein N terminal; Region: TraW_N; cl10149
889738010386	Signal peptidase, peptidase S26; Region: Peptidase_S26; pfam10502
889738010387	type-IV secretion system protein TraC; Region: TraC-F-type; TIGR02746
889738010388	F pilus assembly Type-IV secretion system for plasmid transfer; Region: TraC_F_IV; pfam11130
889738010389	type IV conjugative transfer system lipoprotein TraV; Region: TraV; TIGR02747
889738010390	Type IV conjugative transfer system lipoprotein (TraV); Region: TraV; pfam09676
889738010391	protein disulfide isomerase II DsbC; Provisional; Region: PRK10877
889738010392	DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020
889738010393	dimerization domain [polypeptide binding]; other site
889738010394	dimer interface [polypeptide binding]; other site
889738010395	catalytic residues [active]
889738010396	Flagellar basal body-associated protein FliL; Region: FliL; cl00681
889738010397	Bacterial conjugation TrbI-like protein; Region: TrbI; pfam03743
889738010398	TraK protein; Region: TraK; pfam06586
889738010399	conjugal transfer protein TraK; Provisional; Region: PRK13736; cl05878
889738010400	TraE protein; Region: TraE; cl05060
889738010401	TraL protein; Region: TraL; cl06278
889738010402	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
889738010403	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
889738010404	N-acetyl-D-glucosamine binding site [chemical binding]; other site
889738010405	catalytic residue [active]
889738010406	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
889738010407	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788
889738010408	catalytic residues [active]
889738010409	catalytic nucleophile [active]
889738010410	Protein of unknown function (DUF3312); Region: DUF3312; pfam11768
889738010411	Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dam; COG0338
889738010412	TrwC relaxase; Region: TrwC; pfam08751
889738010413	conjugative relaxase domain, TrwC/TraI family; Region: relax_trwC; TIGR02686
889738010414	ZipA C-terminal domain. ZipA, a membrane-anchored protein, is one of at least nine essential gene products necessary for assembly of the septal ring which mediates cell division in E.coli. ZipA and FtsA directly bind FtsZ, a homolog of eukaryotic...; Region: ZipA; cl12038
889738010415	AAA domain; Region: AAA_30; pfam13604
889738010416	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
889738010417	Type IV secretion-system coupling protein DNA-binding domain; Region: TrwB_AAD_bind; pfam10412
889738010418	Walker A motif; other site
889738010419	ATP binding site [chemical binding]; other site
889738010420	Walker B motif; other site
889738010421	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
889738010422	HSP70 interaction site [polypeptide binding]; other site
889738010423	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
889738010424	potential frameshift: common BLAST hit: gi|385238140|ref|YP_005799479.1| beta-lactamase OXA-23
889738010425	Beta-lactamase class D [Defense mechanisms]; Region: COG2602
889738010426	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
889738010427	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
889738010428	DEAD-like helicases superfamily; Region: DEXDc; smart00487
889738010429	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
889738010430	ATP binding site [chemical binding]; other site
889738010431	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
889738010432	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
889738010433	P-loop; other site
889738010434	Magnesium ion binding site [ion binding]; other site
889738010435	potential frameshift: common BLAST hit: gi|261416835|ref|YP_003250518.1| helicase A859L
889738010436	T5orf172 domain; Region: T5orf172; pfam10544
889738010437	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
889738010438	Polysulphide reductase [Energy production and conversion]; Region: COG5557; cl17901
889738010439	ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180
889738010440	ParB-like nuclease domain; Region: ParB; smart00470
889738010441	KorB domain; Region: KorB; pfam08535
889738010442	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
889738010443	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
889738010444	P-loop; other site
889738010445	Magnesium ion binding site [ion binding]; other site
889738010446	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
889738010447	Magnesium ion binding site [ion binding]; other site
889738010448	Initiator Replication protein; Region: Rep_3; pfam01051
889738010449	41 helicase; Provisional; Region: 41; PHA02542
889738010450	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
889738010451	Toprim-like; Region: Toprim_2; pfam13155
889738010452	active site
889738010453	metal binding site [ion binding]; metal-binding site
889738010454	DNA ligase; Provisional; Region: 30; PHA02587
889738010455	Adenylation domain of proteins similar to ATP-dependent polynucleotide ligases; Region: Adenylation_DNA_ligase_like; cd06846
889738010456	active site
889738010457	The Oligonucleotide/oligosaccharide binding (OB)-fold domain is a DNA-binding module that is part of the catalytic core unit of ATP dependent DNA ligases; Region: OBF_DNA_ligase_family; cl08424
889738010458	Guanylate kinase; Region: Guanylate_kin; pfam00625
889738010459	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190
889738010460	active site
889738010461	CobQ/CobB/MinD/ParA nucleotide binding domain; Region: CbiA; pfam01656
889738010462	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
889738010463	P-loop; other site
889738010464	Magnesium ion binding site [ion binding]; other site
889738010465	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
889738010466	active site
889738010467	catalytic residues [active]
889738010468	DNA binding site [nucleotide binding]
889738010469	Int/Topo IB signature motif; other site
889738010470	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
889738010471	salt bridge; other site
889738010472	non-specific DNA binding site [nucleotide binding]; other site
889738010473	sequence-specific DNA binding site [nucleotide binding]; other site
889738010474	Cobalamin biosynthesis protein CobT; Region: CobT; pfam06213
889738010475	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
889738010476	metal ion-dependent adhesion site (MIDAS); other site
889738010477	AAA domain (dynein-related subfamily); Region: AAA_5; pfam07728
889738010478	Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102
889738010479	PHP domain; Region: PHP; pfam02811
889738010480	active site
889738010481	Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733
889738010482	NUMOD4 motif; Region: NUMOD4; pfam07463
889738010483	HNH endonuclease; Region: HNH_3; pfam13392
889738010484	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393
889738010485	Uracil-DNA glycosylases (UDG) and related enzymes; Region: UDG_like; cl00483
889738010486	ligand binding site [chemical binding]; other site
889738010487	active site
889738010488	PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812
889738010489	5'-3' exonuclease; Region: 53EXOc; smart00475
889738010490	putative active site [active]
889738010491	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
889738010492	putative DNA binding site [nucleotide binding]; other site
889738010493	putative metal binding site [ion binding]; other site
889738010494	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
889738010495	Walker A motif; other site
889738010496	ATP binding site [chemical binding]; other site
889738010497	Walker B motif; other site
889738010498	Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cl17442
889738010499	protein-splicing catalytic site; other site
889738010500	thioester formation/cholesterol transfer; other site
889738010501	Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081
889738010502	protein-splicing catalytic site; other site
889738010503	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
889738010504	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
889738010505	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
889738010506	active site
889738010507	metal binding site [ion binding]; metal-binding site
889738010508	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
889738010509	endonuclease subunit; Provisional; Region: 46; PHA02562
889738010510	Walker A/P-loop; other site
889738010511	ATP binding site [chemical binding]; other site
889738010512	fzo-like conserved region; Region: Fzo_mitofusin; pfam04799
889738010513	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
889738010514	Walker B; other site
889738010515	D-loop; other site
889738010516	H-loop/switch region; other site
889738010517	ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08447
889738010518	ATP cone domain; Region: ATP-cone; pfam03477
889738010519	Class I ribonucleotide reductase; Region: RNR_I; cd01679
889738010520	active site
889738010521	dimer interface [polypeptide binding]; other site
889738010522	catalytic residues [active]
889738010523	effector binding site; other site
889738010524	R2 peptide binding site; other site
889738010525	Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049
889738010526	dimer interface [polypeptide binding]; other site
889738010527	putative radical transfer pathway; other site
889738010528	diiron center [ion binding]; other site
889738010529	tyrosyl radical; other site
889738010530	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in a group of uncharacterized proteins from bacteria and archaea; Region: NTP-PPase_u4; cd11541
889738010531	putative metal binding site [ion binding]; other site
889738010532	AAA domain; Region: AAA_17; pfam13207
889738010533	Prolipoprotein diacylglyceryl transferase; Region: LGT; cl00478
889738010534	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
889738010535	DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847
889738010536	active site
889738010537	catalytic site [active]
889738010538	substrate binding site [chemical binding]; other site
889738010539	Protein of unknown function (DUF2958); Region: DUF2958; pfam11171
889738010540	Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737
889738010541	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
889738010542	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
889738010543	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
889738010544	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
889738010545	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
889738010546	Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933
889738010547	FMN binding site [chemical binding]; other site
889738010548	active site
889738010549	substrate binding site [chemical binding]; other site
889738010550	catalytic residue [active]
889738010551	Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141
889738010552	intracellular protease, PfpI family; Region: PfpI; TIGR01382
889738010553	potential catalytic triad [active]
889738010554	conserved cys residue [active]
889738010555	Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979
889738010556	Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187
889738010557	dimer interface [polypeptide binding]; other site
889738010558	active site
889738010559	metal binding site [ion binding]; metal-binding site
889738010560	Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022
889738010561	S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821
889738010562	S-formylglutathione hydrolase; Region: PLN02442
889738010563	class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300
889738010564	S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase; Region: adh_III_F_hyde; TIGR02818
889738010565	substrate binding site [chemical binding]; other site
889738010566	catalytic Zn binding site [ion binding]; other site
889738010567	NAD binding site [chemical binding]; other site
889738010568	structural Zn binding site [ion binding]; other site
889738010569	dimer interface [polypeptide binding]; other site
889738010570	Transcriptional regulators RcnR and FrmR, and related domains; this domain family was previously known as part of DUF156; Region: RcnR-FrmR-like_DUF156; cd10153
889738010571	putative homodimer interface [polypeptide binding]; other site
889738010572	putative homotetramer interface [polypeptide binding]; other site
889738010573	putative metal binding site [ion binding]; other site
889738010574	putative homodimer-homodimer interface [polypeptide binding]; other site
889738010575	putative allosteric switch controlling residues; other site
889738010576	putative transposase OrfB; Reviewed; Region: PHA02517
889738010577	HTH-like domain; Region: HTH_21; pfam13276
889738010578	Integrase core domain; Region: rve; pfam00665
889738010579	Integrase core domain; Region: rve_2; pfam13333
889738010580	Homeodomain-like domain; Region: HTH_23; cl17451
889738010581	Protein of unknown function (DUF3296); Region: DUF3296; pfam11726
889738010582	Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283
889738010583	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
889738010584	NAD binding site [chemical binding]; other site
889738010585	catalytic Zn binding site [ion binding]; other site
889738010586	structural Zn binding site [ion binding]; other site
889738010587	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
889738010588	Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737
889738010589	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
889738010590	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
889738010591	Type III restriction enzyme, res subunit; Region: ResIII; pfam04851
889738010592	DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061
889738010593	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
889738010594	nucleotide binding region [chemical binding]; other site
889738010595	ATP-binding site [chemical binding]; other site
889738010596	ParB-like nuclease domain; Region: ParBc; pfam02195
889738010597	ParB-like nuclease domain; Region: ParBc; pfam02195
889738010598	Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475
889738010599	ABC-type transport system involved in cytochrome c biogenesis, ATPase component [Posttranslational modification, protein turnover, chaperones]; Region: CcmA; COG4133
889738010600	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267
889738010601	Walker A/P-loop; other site
889738010602	ATP binding site [chemical binding]; other site
889738010603	Q-loop/lid; other site
889738010604	ABC transporter signature motif; other site
889738010605	Walker B; other site
889738010606	D-loop; other site
889738010607	H-loop/switch region; other site
889738010608	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
889738010609	catalytic residues [active]
889738010610	ABC-type ATPase fused to a predicted acetyltransferase domain [General function prediction only]; Region: COG2401
889738010611	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
889738010612	Phage terminase large subunit; Region: Terminase_3; cl12054
889738010613	Terminase-like family; Region: Terminase_6; pfam03237
889738010614	Bacteriophage protein of unknown function (DUF646); Region: DUF646; cl12124
889738010615	Manganese-stabilising protein / photosystem II polypeptide; Region: MSP; cl03326
889738010616	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
889738010617	phage tail tape measure protein, lambda family; Region: tape_meas_lam_C; TIGR01541
889738010618	Phage minor tail protein; Region: Phage_min_tail; cl01940
889738010619	Phage-related protein [Function unknown]; Region: gp18; COG4672
889738010620	Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding) found in proteins also containing NlpC/P60 domains; Region: MPN_NLPC_P60; cd08073
889738010621	MPN+ (JAMM) motif; other site
889738010622	Zinc-binding site [ion binding]; other site
889738010623	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
889738010624	NlpC/P60 family; Region: NLPC_P60; pfam00877
889738010625	Phage-related protein, tail component [Function unknown]; Region: COG4723
889738010626	Phage-related protein, tail component [Function unknown]; Region: COG4733
889738010627	Putative phage tail protein; Region: Phage-tail_3; pfam13550
889738010628	Baculovirus polyhedron envelope protein, PEP, C terminus; Region: Baculo_PEP_C; pfam04513
889738010629	Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737
889738010630	catalytic residues [active]