-- dump date   	20140618_190609
-- class       	Genbank::misc_feature
-- table       	misc_feature_note
-- id	note
497978000001	Cytochrome b562; Region: Cytochrom_B562; pfam07361
497978000002	DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939
497978000003	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
497978000004	ATP binding site [chemical binding]; other site
497978000005	Mg2+ binding site [ion binding]; other site
497978000006	G-X-G motif; other site
497978000007	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
497978000008	anchoring element; other site
497978000009	dimer interface [polypeptide binding]; other site
497978000010	ATP binding site [chemical binding]; other site
497978000011	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
497978000012	active site
497978000013	putative metal-binding site [ion binding]; other site
497978000014	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
497978000015	recombination protein F; Reviewed; Region: recF; PRK00064
497978000016	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
497978000017	Walker A/P-loop; other site
497978000018	ATP binding site [chemical binding]; other site
497978000019	Q-loop/lid; other site
497978000020	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
497978000021	ABC transporter signature motif; other site
497978000022	Walker B; other site
497978000023	D-loop; other site
497978000024	H-loop/switch region; other site
497978000025	DNA polymerase III subunit beta; Validated; Region: PRK05643
497978000026	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
497978000027	putative DNA binding surface [nucleotide binding]; other site
497978000028	dimer interface [polypeptide binding]; other site
497978000029	beta-clamp/clamp loader binding surface; other site
497978000030	beta-clamp/translesion DNA polymerase binding surface; other site
497978000031	DnaA N-terminal domain; Region: DnaA_N; pfam11638
497978000032	chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362
497978000033	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
497978000034	Walker A motif; other site
497978000035	ATP binding site [chemical binding]; other site
497978000036	Walker B motif; other site
497978000037	arginine finger; other site
497978000038	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
497978000039	DnaA box-binding interface [nucleotide binding]; other site
497978000040	50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399
497978000041	Ribonuclease P; Region: Ribonuclease_P; pfam00825
497978000042	hypothetical protein; Provisional; Region: PRK14386
497978000043	membrane protein insertase; Provisional; Region: PRK01318
497978000044	membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592
497978000045	tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291
497978000046	GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396
497978000047	trmE is a tRNA modification GTPase; Region: trmE; cd04164
497978000048	G1 box; other site
497978000049	GTP/Mg2+ binding site [chemical binding]; other site
497978000050	Switch I region; other site
497978000051	G2 box; other site
497978000052	Switch II region; other site
497978000053	G3 box; other site
497978000054	G4 box; other site
497978000055	G5 box; other site
497978000056	Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631
497978000057	Transcriptional regulators RcnR and FrmR, and related domains; this domain family was previously known as part of DUF156; Region: RcnR-FrmR-like_DUF156; cd10153
497978000058	putative metal binding site [ion binding]; other site
497978000059	putative homodimer interface [polypeptide binding]; other site
497978000060	putative homotetramer interface [polypeptide binding]; other site
497978000061	putative homodimer-homodimer interface [polypeptide binding]; other site
497978000062	putative allosteric switch controlling residues; other site
497978000063	Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230
497978000064	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
497978000065	Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651
497978000066	DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020
497978000067	dimerization domain [polypeptide binding]; other site
497978000068	dimer interface [polypeptide binding]; other site
497978000069	catalytic residues [active]
497978000070	Predicted membrane protein [Function unknown]; Region: COG2261
497978000071	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
497978000072	active site
497978000073	guanine deaminase; Provisional; Region: PRK09228
497978000074	Guanine deaminase (GDEase). Guanine deaminase is an aminohydrolase responsible for the conversion of guanine to xanthine and ammonia, the first step to utilize guanine as a nitrogen source. This reaction also removes the guanine base from the pool and...; Region: GDEase; cd01303
497978000075	active site
497978000076	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
497978000077	Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469
497978000078	[2Fe-2S] cluster binding site [ion binding]; other site
497978000079	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
497978000080	hydrophobic ligand binding site; other site
497978000081	Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754
497978000082	integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718
497978000083	PAP2_like proteins, BcrC_like subfamily. Several members of this family have been annotated as bacitracin transport permeases, as it was suspected that they form the permease component of an ABC transporter system. It was shown, however, that BcrC from...; Region: PAP2_BcrC_like; cd03385
497978000084	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
497978000085	active site
497978000086	Bacterial low temperature requirement A protein (LtrA); Region: LtrA; cl01754
497978000087	UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase; Region: mpl; TIGR01081
497978000088	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
497978000089	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
497978000090	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
497978000091	Protein of unknown function, DUF486; Region: DUF486; cl01236
497978000092	AIR carboxylase; Region: AIRC; pfam00731
497978000093	phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019
497978000094	ATP-grasp domain; Region: ATP-grasp; pfam02222
497978000095	Transglycosylase SLT domain; Region: SLT_2; pfam13406
497978000096	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
497978000097	N-acetyl-D-glucosamine binding site [chemical binding]; other site
497978000098	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
497978000099	Dual-action HEIGH metallo-peptidase; Region: Peptidase_M57; pfam12388
497978000100	Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064
497978000101	active site
497978000102	Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064
497978000103	active site
497978000104	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
497978000105	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
497978000106	nucleotide binding site [chemical binding]; other site
497978000107	GrpE; Region: GrpE; pfam01025
497978000108	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
497978000109	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
497978000110	dimer interface [polypeptide binding]; other site
497978000111	Transcriptional regulator [Transcription]; Region: LysR; COG0583
497978000112	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
497978000113	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
497978000114	putative effector binding pocket; other site
497978000115	dimerization interface [polypeptide binding]; other site
497978000116	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
497978000117	Protein of unknown function (DUF2424); Region: DUF2424; pfam10340
497978000118	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
497978000119	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
497978000120	peptidyl-prolyl cis-trans isomerase A (rotamase A); Provisional; Region: PRK10903
497978000121	cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920
497978000122	substrate binding site [chemical binding]; other site
497978000123	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
497978000124	Ankyrin repeats (many copies); Region: Ank_4; pfam13637
497978000125	Ankyrin repeats (many copies); Region: Ank_4; pfam13637
497978000126	Predicted flavoprotein [General function prediction only]; Region: COG0431
497978000127	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
497978000128	FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095
497978000129	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
497978000130	lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376
497978000131	isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743
497978000132	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
497978000133	active site
497978000134	HIGH motif; other site
497978000135	nucleotide binding site [chemical binding]; other site
497978000136	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
497978000137	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
497978000138	active site
497978000139	KMSKS motif; other site
497978000140	Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960
497978000141	tRNA binding surface [nucleotide binding]; other site
497978000142	anticodon binding site; other site
497978000143	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
497978000144	bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627
497978000145	FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064
497978000146	active site
497978000147	Riboflavin kinase; Region: Flavokinase; smart00904
497978000148	Tellurite resistance protein and related permeases [Inorganic ion transport and metabolism]; Region: TehA; COG1275
497978000149	Tellurite-resistance/Dicarboxylate Transporter (TDT) family includes sulfite sensitivity protein (sulfite efflux pump; SSU1); Region: TDT_SSU1; cd09318
497978000150	gating phenylalanine in ion channel; other site
497978000151	Phosphorylase superfamily; Region: PNP_UDP_1; cl00303
497978000152	pyrimidine utilization regulatory protein R; Region: RutR; TIGR03613
497978000153	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
497978000154	YcdC-like protein, C-terminal region; Region: TetR_C_3; pfam08362
497978000155	aliphatic sulfonates transport ATP-binding subunit; Provisional; Region: ssuB; PRK11247
497978000156	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
497978000157	Walker A/P-loop; other site
497978000158	ATP binding site [chemical binding]; other site
497978000159	Q-loop/lid; other site
497978000160	ABC transporter signature motif; other site
497978000161	Walker B; other site
497978000162	D-loop; other site
497978000163	H-loop/switch region; other site
497978000164	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
497978000165	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
497978000166	putative PBP binding loops; other site
497978000167	dimer interface [polypeptide binding]; other site
497978000168	ABC-ATPase subunit interface; other site
497978000169	alkanesulfonate monooxygenase; Provisional; Region: PRK00719
497978000170	Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094
497978000171	active site
497978000172	dimer interface [polypeptide binding]; other site
497978000173	non-prolyl cis peptide bond; other site
497978000174	insertion regions; other site
497978000175	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
497978000176	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
497978000177	substrate binding pocket [chemical binding]; other site
497978000178	membrane-bound complex binding site; other site
497978000179	hinge residues; other site
497978000180	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
497978000181	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
497978000182	substrate binding pocket [chemical binding]; other site
497978000183	membrane-bound complex binding site; other site
497978000184	hinge residues; other site
497978000185	N-acetylglutamate synthase; Validated; Region: PRK05279
497978000186	AAK_NAGS-ABP: N-acetylglutamate (NAG) kinase-like domain of the NAG Synthase (NAGS) of the arginine-biosynthesis pathway (ABP) found in gamma- and beta-proteobacteria and higher plant chloroplasts. Domain architecture of these NAGS consisted of an...; Region: AAK_NAGS-ABP; cd04237
497978000187	putative feedback inhibition sensing region; other site
497978000188	putative nucleotide binding site [chemical binding]; other site
497978000189	putative substrate binding site [chemical binding]; other site
497978000190	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
497978000191	Coenzyme A binding pocket [chemical binding]; other site
497978000192	Domain of unknown function (DUF3315); Region: DUF3315; pfam11776
497978000193	Domain of unknown function (DUF3315); Region: DUF3315; pfam11776
497978000194	putative oxoacyl-(acyl carrier protein) reductase; Provisional; Region: PRK08945
497978000195	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
497978000196	NAD(P) binding site [chemical binding]; other site
497978000197	active site
497978000198	phosphoglycolate phosphatase; Provisional; Region: PRK13222
497978000199	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
497978000200	active site
497978000201	motif I; other site
497978000202	motif II; other site
497978000203	bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134
497978000204	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
497978000205	S-adenosylmethionine binding site [chemical binding]; other site
497978000206	DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019
497978000207	catalytic residues [active]
497978000208	hinge region; other site
497978000209	alpha helical domain; other site
497978000210	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
497978000211	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
497978000212	DNA-binding transcriptional repressor FabR; Provisional; Region: PRK11202
497978000213	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
497978000214	Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_2; cd06216
497978000215	FMN reductase; Validated; Region: fre; PRK08051
497978000216	FAD binding pocket [chemical binding]; other site
497978000217	FAD binding motif [chemical binding]; other site
497978000218	phosphate binding motif [ion binding]; other site
497978000219	beta-alpha-beta structure motif; other site
497978000220	NAD binding pocket [chemical binding]; other site
497978000221	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
497978000222	catalytic loop [active]
497978000223	iron binding site [ion binding]; other site
497978000224	Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239
497978000225	The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506
497978000226	putative di-iron ligands [ion binding]; other site
497978000227	ribonuclease PH; Reviewed; Region: rph; PRK00173
497978000228	Ribonuclease PH; Region: RNase_PH_bact; cd11362
497978000229	hexamer interface [polypeptide binding]; other site
497978000230	active site
497978000231	phospholipase C, phosphocholine-specific, Pseudomonas-type; Region: PC_PLC; TIGR03396
497978000232	Phosphoesterase family; Region: Phosphoesterase; pfam04185
497978000233	Domain of unknown function (DUF756); Region: DUF756; pfam05506
497978000234	Domain of unknown function (DUF756); Region: DUF756; pfam05506
497978000235	quinolinate phosphoribosyltransferase; Validated; Region: PRK09016
497978000236	Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572
497978000237	dimerization interface [polypeptide binding]; other site
497978000238	active site
497978000239	N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023
497978000240	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
497978000241	amidase catalytic site [active]
497978000242	Zn binding residues [ion binding]; other site
497978000243	substrate binding site [chemical binding]; other site
497978000244	Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728
497978000245	MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123
497978000246	Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346
497978000247	FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545
497978000248	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
497978000249	Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346
497978000250	FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545
497978000251	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
497978000252	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
497978000253	Low molecular weight phosphatase family; Region: LMWPc; cd00115
497978000254	Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451
497978000255	active site
497978000256	polysaccharide export protein Wza; Provisional; Region: PRK15078
497978000257	Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563
497978000258	Vi polysaccharide biosynthesis protein TviB; Provisional; Region: PRK15182
497978000259	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
497978000260	UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984
497978000261	UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237
497978000262	Polysaccharide biosynthesis protein; Region: Polysacc_synt_2; pfam02719
497978000263	NAD(P) binding site [chemical binding]; other site
497978000264	homodimer interface [polypeptide binding]; other site
497978000265	substrate binding site [chemical binding]; other site
497978000266	active site
497978000267	aminotransferase, LLPSF_NHT_00031 family; Region: NHT_00031; TIGR04181
497978000268	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
497978000269	inhibitor-cofactor binding pocket; inhibition site
497978000270	pyridoxal 5'-phosphate binding site [chemical binding]; other site
497978000271	catalytic residue [active]
497978000272	UDP-N-acetyl-D-glucosamine 2-epimerase, UDP-hydrolysing; Region: NeuC_NnaA; TIGR03568
497978000273	Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase  family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786
497978000274	active site
497978000275	homodimer interface [polypeptide binding]; other site
497978000276	N-acetylneuraminate synthase; Region: NeuB_NnaB; TIGR03569
497978000277	NeuB family; Region: NeuB; pfam03102
497978000278	C-terminal SAF domain of sialic acid synthetase; Region: SAF_NeuB_like; cd11615
497978000279	NeuB binding interface [polypeptide binding]; other site
497978000280	putative substrate binding site [chemical binding]; other site
497978000281	FOG: CBS domain [General function prediction only]; Region: COG0517
497978000282	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain associated with the NTP (Nucleotidyl transferase) domain downstream. CBS is a small domain originally identified in cystathionine beta-synthase and subsequently...; Region: CBS_pair_NTP_transferase_assoc; cd04607
497978000283	NTP_trnasferase_like_2 is a member of the nucleotidyl transferase family; Region: NTP_transferase_like_2; cd06426
497978000284	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
497978000285	Substrate binding site; other site
497978000286	metal-binding site
497978000287	CMP-NeuAc_Synthase activates N-acetylneuraminic acid by adding CMP moiety; Region: CMP-NeuAc_Synthase; cd02513
497978000288	ligand binding site; other site
497978000289	tetramer interface; other site
497978000290	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
497978000291	Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128
497978000292	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
497978000293	UDP-N-acetylglucosamine 4,6-dehydratase/5-epimerase; Region: FnlA; TIGR04130
497978000294	UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237
497978000295	NAD(P) binding site [chemical binding]; other site
497978000296	homodimer interface [polypeptide binding]; other site
497978000297	substrate binding site [chemical binding]; other site
497978000298	active site
497978000299	Polysaccharide biosynthesis protein C-terminal; Region: Polysacc_syn_2C; pfam08485
497978000300	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
497978000301	NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370
497978000302	NAD(P) binding site [chemical binding]; other site
497978000303	active site
497978000304	dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfbC; COG1898
497978000305	UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381
497978000306	Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase  family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786
497978000307	active site
497978000308	homodimer interface [polypeptide binding]; other site
497978000309	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
497978000310	This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen.  It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794
497978000311	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
497978000312	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
497978000313	NAD(P) binding site [chemical binding]; other site
497978000314	active site
497978000315	Bacterial sugar transferase; Region: Bac_transf; pfam02397
497978000316	Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541
497978000317	dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209
497978000318	active site
497978000319	tetramer interface; other site
497978000320	Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004
497978000321	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
497978000322	UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984
497978000323	glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179
497978000324	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015
497978000325	active site
497978000326	dimer interface [polypeptide binding]; other site
497978000327	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016
497978000328	dimer interface [polypeptide binding]; other site
497978000329	active site
497978000330	UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247
497978000331	UDP-glucose 4-epimerase; Region: PLN02240
497978000332	NAD binding site [chemical binding]; other site
497978000333	homodimer interface [polypeptide binding]; other site
497978000334	active site
497978000335	substrate binding site [chemical binding]; other site
497978000336	phosphomannomutase CpsG; Provisional; Region: PRK15414
497978000337	The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089
497978000338	active site
497978000339	substrate binding site [chemical binding]; other site
497978000340	metal binding site [ion binding]; metal-binding site
497978000341	L-lactate permease; Provisional; Region: PRK10420
497978000342	glycolate transporter; Provisional; Region: PRK09695
497978000343	DNA-binding transcriptional repressor LldR; Provisional; Region: PRK10421
497978000344	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
497978000345	DNA-binding site [nucleotide binding]; DNA binding site
497978000346	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
497978000347	L-lactate dehydrogenase; Provisional; Region: lldD; PRK11197
497978000348	Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809
497978000349	active site
497978000350	substrate binding site [chemical binding]; other site
497978000351	FMN binding site [chemical binding]; other site
497978000352	putative catalytic residues [active]
497978000353	D-lactate dehydrogenase; Provisional; Region: PRK11183
497978000354	FAD binding domain; Region: FAD_binding_4; pfam01565
497978000355	D-lactate dehydrogenase, membrane binding; Region: Lact-deh-memb; pfam09330
497978000356	aromatic amino acid aminotransferase; Provisional; Region: PRK09257
497978000357	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
497978000358	pyridoxal 5'-phosphate binding site [chemical binding]; other site
497978000359	homodimer interface [polypeptide binding]; other site
497978000360	catalytic residue [active]
497978000361	Transcriptional regulators [Transcription]; Region: GntR; COG1802
497978000362	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
497978000363	DNA-binding site [nucleotide binding]; DNA binding site
497978000364	FCD domain; Region: FCD; pfam07729
497978000365	Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714
497978000366	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
497978000367	tetramer interface [polypeptide binding]; other site
497978000368	active site
497978000369	Mg2+/Mn2+ binding site [ion binding]; other site
497978000370	Citrate synthase [Energy production and conversion]; Region: GltA; COG0372
497978000371	methylcitrate synthase; Provisional; Region: PRK12351
497978000372	oxalacetate binding site [chemical binding]; other site
497978000373	citrylCoA binding site [chemical binding]; other site
497978000374	coenzyme A binding site [chemical binding]; other site
497978000375	catalytic triad [active]
497978000376	2-methylisocitrate dehydratase, Fe/S-dependent; Region: 2met_isocit_dHY; TIGR02333
497978000377	Aconitase A catalytic domain; Region: AcnA_IRP; cd01586
497978000378	substrate binding site [chemical binding]; other site
497978000379	ligand binding site [chemical binding]; other site
497978000380	Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215
497978000381	substrate binding site [chemical binding]; other site
497978000382	Domain of unknown function (DUF4126); Region: DUF4126; pfam13548
497978000383	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
497978000384	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
497978000385	Coenzyme A binding pocket [chemical binding]; other site
497978000386	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
497978000387	nudix motif; other site
497978000388	3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK07967
497978000389	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
497978000390	dimer interface [polypeptide binding]; other site
497978000391	active site
497978000392	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
497978000393	NAD(P) binding site [chemical binding]; other site
497978000394	active site
497978000395	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
497978000396	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
497978000397	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
497978000398	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
497978000399	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
497978000400	Predicted membrane protein [Function unknown]; Region: COG4420
497978000401	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
497978000402	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
497978000403	active site
497978000404	Protein of unknown function (DUF1260); Region: DUF1260; pfam06877
497978000405	SnoaL-like domain; Region: SnoaL_2; pfam12680
497978000406	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
497978000407	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
497978000408	N-terminal plug; other site
497978000409	ligand-binding site [chemical binding]; other site
497978000410	Predicted membrane protein [Function unknown]; Region: COG3503
497978000411	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
497978000412	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
497978000413	putative DNA binding site [nucleotide binding]; other site
497978000414	putative Zn2+ binding site [ion binding]; other site
497978000415	AsnC family; Region: AsnC_trans_reg; pfam01037
497978000416	D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711
497978000417	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
497978000418	mRNA stabilisation; Region: mRNA_stabil; pfam13929
497978000419	alanine racemase; Reviewed; Region: dadX; PRK03646
497978000420	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827
497978000421	active site
497978000422	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
497978000423	substrate binding site [chemical binding]; other site
497978000424	catalytic residues [active]
497978000425	dimer interface [polypeptide binding]; other site
497978000426	This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function.  The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150
497978000427	homotrimer interaction site [polypeptide binding]; other site
497978000428	putative active site [active]
497978000429	D-alanine/D-serine/glycine permease; Provisional; Region: PRK11049
497978000430	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
497978000431	Transcriptional regulator [Transcription]; Region: LysR; COG0583
497978000432	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
497978000433	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
497978000434	dimerization interface [polypeptide binding]; other site
497978000435	Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085
497978000436	methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722
497978000437	tetrameric interface [polypeptide binding]; other site
497978000438	NAD binding site [chemical binding]; other site
497978000439	catalytic residues [active]
497978000440	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
497978000441	3-hydroxyisobutyrate dehydrogenase; Region: HIBADH; TIGR01692
497978000442	Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365
497978000443	Domain of unknown function (DUF3448); Region: DUF3448; pfam11930
497978000444	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
497978000445	acyl-activating enzyme (AAE) consensus motif; other site
497978000446	AMP binding site [chemical binding]; other site
497978000447	active site
497978000448	CoA binding site [chemical binding]; other site
497978000449	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
497978000450	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
497978000451	active site
497978000452	enoyl-CoA hydratase; Provisional; Region: PRK05862
497978000453	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
497978000454	substrate binding site [chemical binding]; other site
497978000455	oxyanion hole (OAH) forming residues; other site
497978000456	trimer interface [polypeptide binding]; other site
497978000457	3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617
497978000458	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
497978000459	substrate binding site [chemical binding]; other site
497978000460	oxyanion hole (OAH) forming residues; other site
497978000461	trimer interface [polypeptide binding]; other site
497978000462	2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766
497978000463	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
497978000464	metabolite-proton symporter; Region: 2A0106; TIGR00883
497978000465	putative substrate translocation pore; other site
497978000466	Autoinducer synthetase; Region: Autoind_synth; cl17404
497978000467	DNA-binding transcriptional activator SdiA; Provisional; Region: PRK10188
497978000468	Autoinducer binding domain; Region: Autoind_bind; pfam03472
497978000469	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
497978000470	DNA binding residues [nucleotide binding]
497978000471	dimerization interface [polypeptide binding]; other site
497978000472	acyl-CoA synthetase; Validated; Region: PRK05850
497978000473	Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931
497978000474	acyl-activating enzyme (AAE) consensus motif; other site
497978000475	active site
497978000476	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
497978000477	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
497978000478	active site
497978000479	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
497978000480	Condensation domain; Region: Condensation; pfam00668
497978000481	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
497978000482	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
497978000483	The adenylation domain of nonribosomal peptide synthetases (NRPS), including salinosporamide A polyketide synthase; Region: A_NRPS_Ta1_like; cd12116
497978000484	acyl-activating enzyme (AAE) consensus motif; other site
497978000485	AMP binding site [chemical binding]; other site
497978000486	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
497978000487	Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319
497978000488	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
497978000489	hydrophobic ligand binding site; other site
497978000490	Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033
497978000491	Protein of unknown function (DUF1329); Region: DUF1329; pfam07044
497978000492	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
497978000493	NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370
497978000494	NAD(P) binding site [chemical binding]; other site
497978000495	active site
497978000496	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
497978000497	Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303
497978000498	catalytic site [active]
497978000499	Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091
497978000500	4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648
497978000501	Stress-induced morphogen (activity unknown) [Signal transduction mechanisms]; Region: BolA; COG0271
497978000502	Invasion gene expression up-regulator, SirB; Region: SirB; cl01184
497978000503	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
497978000504	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
497978000505	P-loop; other site
497978000506	Magnesium ion binding site [ion binding]; other site
497978000507	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
497978000508	Magnesium ion binding site [ion binding]; other site
497978000509	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
497978000510	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
497978000511	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
497978000512	Predicted membrane protein [Function unknown]; Region: COG2259
497978000513	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399
497978000514	GMP synthase; Reviewed; Region: guaA; PRK00074
497978000515	Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742
497978000516	AMP/PPi binding site [chemical binding]; other site
497978000517	candidate oxyanion hole; other site
497978000518	catalytic triad [active]
497978000519	potential glutamine specificity residues [chemical binding]; other site
497978000520	The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997
497978000521	ATP Binding subdomain [chemical binding]; other site
497978000522	Ligand Binding sites [chemical binding]; other site
497978000523	Dimerization subdomain; other site
497978000524	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
497978000525	active site
497978000526	NTP binding site [chemical binding]; other site
497978000527	metal binding triad [ion binding]; metal-binding site
497978000528	antibiotic binding site [chemical binding]; other site
497978000529	Domain of unknown function (DUF4111); Region: DUF4111; pfam13427
497978000530	Predicted transcriptional regulators [Transcription]; Region: COG1695
497978000531	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
497978000532	Domain of Unknown Function with PDB structure (DUF3861); Region: DUF3861; pfam12977
497978000533	Pirin; Region: Pirin; pfam02678
497978000534	Pirin-related protein [General function prediction only]; Region: COG1741
497978000535	Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726
497978000536	OsmC-like protein; Region: OsmC; pfam02566
497978000537	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
497978000538	GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046
497978000539	putative C-terminal domain interface [polypeptide binding]; other site
497978000540	putative GSH binding site (G-site) [chemical binding]; other site
497978000541	putative dimer interface [polypeptide binding]; other site
497978000542	C-terminal, alpha helical domain of GTT1-like Glutathione S-transferases; Region: GST_C_GTT1_like; cd03189
497978000543	putative N-terminal domain interface [polypeptide binding]; other site
497978000544	putative dimer interface [polypeptide binding]; other site
497978000545	putative substrate binding pocket (H-site) [chemical binding]; other site
497978000546	Sporulation related domain; Region: SPOR; pfam05036
497978000547	Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016
497978000548	Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018
497978000549	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
497978000550	active site
497978000551	HIGH motif; other site
497978000552	nucleotide binding site [chemical binding]; other site
497978000553	catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
497978000554	KMSK motif region; other site
497978000555	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
497978000556	tRNA binding surface [nucleotide binding]; other site
497978000557	anticodon binding site; other site
497978000558	malate dehydrogenase; Provisional; Region: PRK13529
497978000559	Malic enzyme, N-terminal domain; Region: malic; pfam00390
497978000560	NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312
497978000561	NAD(P) binding site [chemical binding]; other site
497978000562	Dyp-type peroxidase family; Region: Dyp_perox; cl01067
497978000563	LysE type translocator; Region: LysE; cl00565
497978000564	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
497978000565	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
497978000566	ABC-ATPase subunit  interface; other site
497978000567	dimer interface [polypeptide binding]; other site
497978000568	putative PBP binding regions; other site
497978000569	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
497978000570	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
497978000571	Walker A/P-loop; other site
497978000572	ATP binding site [chemical binding]; other site
497978000573	Q-loop/lid; other site
497978000574	ABC transporter signature motif; other site
497978000575	Walker B; other site
497978000576	D-loop; other site
497978000577	H-loop/switch region; other site
497978000578	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cl17326
497978000579	metal binding site 2 [ion binding]; metal-binding site
497978000580	putative DNA binding helix; other site
497978000581	metal binding site 1 [ion binding]; metal-binding site
497978000582	dimer interface [polypeptide binding]; other site
497978000583	structural Zn2+ binding site [ion binding]; other site
497978000584	Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297
497978000585	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
497978000586	intersubunit interface [polypeptide binding]; other site
497978000587	F0F1 ATP synthase subunit I; Validated; Region: PRK05760
497978000588	F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356
497978000589	F0F1 ATP synthase subunit A; Validated; Region: PRK05815
497978000590	F0F1 ATP synthase subunit C; Validated; Region: PRK06876
497978000591	F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711
497978000592	F0F1 ATP synthase subunit B; Validated; Region: PRK05759
497978000593	F0F1 ATP synthase subunit delta; Validated; Region: PRK05758
497978000594	ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213
497978000595	F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281
497978000596	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
497978000597	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
497978000598	Walker A motif; other site
497978000599	ATP binding site [chemical binding]; other site
497978000600	Walker B motif; other site
497978000601	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
497978000602	mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151
497978000603	core domain interface [polypeptide binding]; other site
497978000604	delta subunit interface [polypeptide binding]; other site
497978000605	epsilon subunit interface [polypeptide binding]; other site
497978000606	F0F1 ATP synthase subunit beta; Validated; Region: PRK09280
497978000607	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
497978000608	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
497978000609	alpha subunit interaction interface [polypeptide binding]; other site
497978000610	Walker A motif; other site
497978000611	ATP binding site [chemical binding]; other site
497978000612	Walker B motif; other site
497978000613	inhibitor binding site; inhibition site
497978000614	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
497978000615	F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571
497978000616	mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152
497978000617	gamma subunit interface [polypeptide binding]; other site
497978000618	epsilon subunit interface [polypeptide binding]; other site
497978000619	LBP interface [polypeptide binding]; other site
497978000620	Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340
497978000621	catalytic residues [active]
497978000622	dimer interface [polypeptide binding]; other site
497978000623	Helix-turn-helix domain; Region: HTH_18; pfam12833
497978000624	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
497978000625	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
497978000626	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
497978000627	putative substrate translocation pore; other site
497978000628	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
497978000629	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
497978000630	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
497978000631	EamA-like transporter family; Region: EamA; pfam00892
497978000632	EamA-like transporter family; Region: EamA; pfam00892
497978000633	Telomere recombination; Region: Sua5_yciO_yrdC; cl00305
497978000634	DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481
497978000635	DNA protecting protein DprA; Region: dprA; TIGR00732
497978000636	Uncharacterized protein containing LysM domain [Function unknown]; Region: XkdP; COG1652
497978000637	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
497978000638	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
497978000639	active site
497978000640	catalytic residues [active]
497978000641	metal binding site [ion binding]; metal-binding site
497978000642	TonB-dependent copper receptor; Region: TonB-copper; TIGR01778
497978000643	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
497978000644	N-terminal plug; other site
497978000645	ligand-binding site [chemical binding]; other site
497978000646	Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; pfam09995
497978000647	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
497978000648	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
497978000649	Acetyltransferase (GNAT) domain; Region: Acetyltransf_9; pfam13527
497978000650	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
497978000651	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
497978000652	dimer interface [polypeptide binding]; other site
497978000653	pyridoxal 5'-phosphate binding site [chemical binding]; other site
497978000654	catalytic residue [active]
497978000655	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
497978000656	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
497978000657	N-acetyl-D-glucosamine binding site [chemical binding]; other site
497978000658	catalytic residue [active]
497978000659	Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655
497978000660	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
497978000661	Protein of unknown function (DUF2938); Region: DUF2938; pfam11158
497978000662	Cu(I)-responsive transcriptional regulator; Region: CueR; TIGR02044
497978000663	Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg6; cd04781
497978000664	DNA binding residues [nucleotide binding]
497978000665	putative dimer interface [polypeptide binding]; other site
497978000666	putative metal binding residues [ion binding]; other site
497978000667	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4222
497978000668	Class II Chelatase: a family of ATP-independent monomeric or homodimeric enzymes that catalyze the insertion of metal into protoporphyrin rings. This family includes protoporphyrin IX ferrochelatase (HemH), sirohydrochlorin ferrochelatase (SirB) and the...; Region: Chelatase_Class_II; cl02784
497978000669	hypothetical protein; Provisional; Region: PRK01254
497978000670	Radical SAM N-terminal; Region: Radical_SAM_N; pfam08497
497978000671	Radical SAM N-terminal; Region: Radical_SAM_N; pfam08497
497978000672	Domain of unknown function (DUF3362); Region: DUF3362; pfam11842
497978000673	Protein of unknown function (DUF2726); Region: DUF2726; pfam10881
497978000674	This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function.  The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150
497978000675	homotrimer interaction site [polypeptide binding]; other site
497978000676	putative active site [active]
497978000677	DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586
497978000678	active site
497978000679	DNA polymerase IV; Validated; Region: PRK02406
497978000680	DNA binding site [nucleotide binding]
497978000681	Uncharacterized bacterial muramidase containing a glycosyl hydrolase family 25 (GH25) catalytic domain. Endo-N-acetylmuramidases are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis...; Region: GH25_muramidase_1; cd06413
497978000682	active site
497978000683	Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183
497978000684	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
497978000685	putative transporter; Provisional; Region: PRK10504
497978000686	putative substrate translocation pore; other site
497978000687	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
497978000688	Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695
497978000689	Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861
497978000690	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
497978000691	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
497978000692	Transporter associated domain; Region: CorC_HlyC; smart01091
497978000693	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3012
497978000694	Predicted membrane protein [Function unknown]; Region: COG2860
497978000695	UPF0126 domain; Region: UPF0126; pfam03458
497978000696	UPF0126 domain; Region: UPF0126; pfam03458
497978000697	benzoate transport; Region: 2A0115; TIGR00895
497978000698	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
497978000699	putative substrate translocation pore; other site
497978000700	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
497978000701	DNA topoisomerase IV subunit A; Validated; Region: PRK05561
497978000702	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
497978000703	CAP-like domain; other site
497978000704	active site
497978000705	primary dimer interface [polypeptide binding]; other site
497978000706	Long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07059
497978000707	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
497978000708	Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936
497978000709	acyl-activating enzyme (AAE) consensus motif; other site
497978000710	putative AMP binding site [chemical binding]; other site
497978000711	putative active site [active]
497978000712	putative CoA binding site [chemical binding]; other site
497978000713	Predicted membrane protein [Function unknown]; Region: COG3686
497978000714	Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412
497978000715	dimer interface [polypeptide binding]; other site
497978000716	substrate binding site [chemical binding]; other site
497978000717	metal binding sites [ion binding]; metal-binding site
497978000718	outer membrane porin, OprD family; Region: OprD; pfam03573
497978000719	Bacterial protein of unknown function (Gcw_chp); Region: Gcw_chp; cl09901
497978000720	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
497978000721	Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408
497978000722	inhibitor site; inhibition site
497978000723	active site
497978000724	dimer interface [polypeptide binding]; other site
497978000725	catalytic residue [active]
497978000726	class II aldolase/adducin domain protein; Provisional; Region: PRK07090
497978000727	intersubunit interface [polypeptide binding]; other site
497978000728	active site
497978000729	Zn2+ binding site [ion binding]; other site
497978000730	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
497978000731	DNA-binding site [nucleotide binding]; DNA binding site
497978000732	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
497978000733	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
497978000734	pyridoxal 5'-phosphate binding site [chemical binding]; other site
497978000735	homodimer interface [polypeptide binding]; other site
497978000736	catalytic residue [active]
497978000737	Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606
497978000738	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078
497978000739	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335
497978000740	TnsA endonuclease N terminal; Region: Tn7_Tnp_TnsA_N; pfam08722
497978000741	Helix-turn-helix domain; Region: HTH_28; pfam13518
497978000742	Integrase core domain; Region: rve; pfam00665
497978000743	Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299
497978000744	Bacterial TniB protein; Region: TniB; pfam05621
497978000745	AAA domain; Region: AAA_22; pfam13401
497978000746	formamidopyrimidine-DNA glycosylase; Provisional; Region: PRK14811
497978000747	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
497978000748	Ligand Binding Site [chemical binding]; other site
497978000749	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
497978000750	Ligand Binding Site [chemical binding]; other site
497978000751	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
497978000752	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
497978000753	Sulfate transporter family; Region: Sulfate_transp; pfam00916
497978000754	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
497978000755	AAA domain; Region: AAA_33; pfam13671
497978000756	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4185
497978000757	site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236
497978000758	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
497978000759	active site
497978000760	DNA binding site [nucleotide binding]
497978000761	Int/Topo IB signature motif; other site
497978000762	TnsA endonuclease N terminal; Region: Tn7_Tnp_TnsA_N; pfam08722
497978000763	Helix-turn-helix domain; Region: HTH_28; pfam13518
497978000764	Integrase core domain; Region: rve; pfam00665
497978000765	Bacterial TniB protein; Region: TniB; pfam05621
497978000766	AAA domain; Region: AAA_22; pfam13401
497978000767	formamidopyrimidine-DNA glycosylase; Provisional; Region: PRK14811
497978000768	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
497978000769	Ligand Binding Site [chemical binding]; other site
497978000770	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
497978000771	Ligand Binding Site [chemical binding]; other site
497978000772	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
497978000773	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
497978000774	Sulfate transporter family; Region: Sulfate_transp; pfam00916
497978000775	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
497978000776	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
497978000777	Major Facilitator Superfamily; Region: MFS_1; pfam07690
497978000778	putative substrate translocation pore; other site
497978000779	tetracycline repressor protein TetR; Provisional; Region: PRK13756
497978000780	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
497978000781	Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909
497978000782	Transposase zinc-binding domain; Region: Zn_Tnp_IS91; pfam14319
497978000783	Putative transposase; Region: Y2_Tnp; pfam04986
497978000784	Aminoglycoside/hydroxyurea antibiotic resistance kinase; Region: APH_6_hur; pfam04655
497978000785	Aminoglycoside 3'-phosphotransferase (APH). The APH subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin...; Region: APH; cd05150
497978000786	Phosphotransferase enzyme family; Region: APH; pfam01636
497978000787	active site
497978000788	ATP binding site [chemical binding]; other site
497978000789	antibiotic binding site [chemical binding]; other site
497978000790	Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606
497978000791	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
497978000792	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078
497978000793	Membrane fusogenic activity; Region: BMFP; pfam04380
497978000794	Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347
497978000795	Nitrogen regulatory protein P-II; Region: P-II; smart00938
497978000796	Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004
497978000797	transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464
497978000798	ATP cone domain; Region: ATP-cone; pfam03477
497978000799	bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase; Provisional; Region: ribD; PRK10786
497978000800	Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284
497978000801	catalytic motif [active]
497978000802	Zn binding site [ion binding]; other site
497978000803	RibD C-terminal domain; Region: RibD_C; cl17279
497978000804	Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG3392
497978000805	D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; cl17344
497978000806	riboflavin synthase subunit alpha; Provisional; Region: PRK09289
497978000807	Lumazine binding domain; Region: Lum_binding; pfam00677
497978000808	Lumazine binding domain; Region: Lum_binding; pfam00677
497978000809	DNA polymerase III chi subunit, HolC; Region: DNA_pol3_chi; pfam04364
497978000810	multifunctional aminopeptidase A; Provisional; Region: PRK00913
497978000811	Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433
497978000812	interface (dimer of trimers) [polypeptide binding]; other site
497978000813	Substrate-binding/catalytic site; other site
497978000814	Zn-binding sites [ion binding]; other site
497978000815	Predicted permeases [General function prediction only]; Region: COG0795; cl12074
497978000816	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
497978000817	Predicted permeases [General function prediction only]; Region: COG0795; cl12074
497978000818	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
497978000819	phosphoglyceromutase; Provisional; Region: PRK05434
497978000820	Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696
497978000821	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
497978000822	C-terminal peptidase (prc); Region: prc; TIGR00225
497978000823	PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cd00136
497978000824	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
497978000825	Catalytic dyad [active]
497978000826	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
497978000827	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
497978000828	active site
497978000829	phosphorylation site [posttranslational modification]
497978000830	intermolecular recognition site; other site
497978000831	dimerization interface [polypeptide binding]; other site
497978000832	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
497978000833	Walker A motif; other site
497978000834	ATP binding site [chemical binding]; other site
497978000835	Walker B motif; other site
497978000836	arginine finger; other site
497978000837	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
497978000838	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
497978000839	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
497978000840	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
497978000841	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
497978000842	dimer interface [polypeptide binding]; other site
497978000843	phosphorylation site [posttranslational modification]
497978000844	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
497978000845	ATP binding site [chemical binding]; other site
497978000846	Mg2+ binding site [ion binding]; other site
497978000847	G-X-G motif; other site
497978000848	response regulator; Provisional; Region: PRK09483
497978000849	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
497978000850	active site
497978000851	phosphorylation site [posttranslational modification]
497978000852	intermolecular recognition site; other site
497978000853	dimerization interface [polypeptide binding]; other site
497978000854	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
497978000855	DNA binding residues [nucleotide binding]
497978000856	dimerization interface [polypeptide binding]; other site
497978000857	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
497978000858	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768
497978000859	threonine synthase; Reviewed; Region: PRK06721
497978000860	Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of  threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563
497978000861	homodimer interface [polypeptide binding]; other site
497978000862	pyridoxal 5'-phosphate binding site [chemical binding]; other site
497978000863	catalytic residue [active]
497978000864	homoserine dehydrogenase; Provisional; Region: PRK06349
497978000865	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
497978000866	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
497978000867	ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881
497978000868	Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651
497978000869	DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020
497978000870	dimerization domain [polypeptide binding]; other site
497978000871	dimer interface [polypeptide binding]; other site
497978000872	catalytic residues [active]
497978000873	site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283
497978000874	XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798
497978000875	active site
497978000876	Int/Topo IB signature motif; other site
497978000877	FeoA domain; Region: FeoA; pfam04023
497978000878	Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370
497978000879	Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879
497978000880	G1 box; other site
497978000881	GTP/Mg2+ binding site [chemical binding]; other site
497978000882	Switch I region; other site
497978000883	G2 box; other site
497978000884	G3 box; other site
497978000885	Switch II region; other site
497978000886	G4 box; other site
497978000887	G5 box; other site
497978000888	Nucleoside recognition; Region: Gate; pfam07670
497978000889	Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664
497978000890	Nucleoside recognition; Region: Gate; pfam07670
497978000891	UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK03803
497978000892	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
497978000893	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
497978000894	cell division protein FtsW; Region: ftsW; TIGR02614
497978000895	glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710
497978000896	active site
497978000897	nucleotide binding site [chemical binding]; other site
497978000898	HIGH motif; other site
497978000899	KMSKS motif; other site
497978000900	RNA polymerase-binding protein DksA; Region: dksA; TIGR02420
497978000901	Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402
497978000902	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
497978000903	active site
497978000904	metal binding site [ion binding]; metal-binding site
497978000905	hexamer interface [polypeptide binding]; other site
497978000906	ADP-ribose pyrophosphatase NudF; Provisional; Region: nudF; PRK10729
497978000907	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
497978000908	dimer interface [polypeptide binding]; other site
497978000909	ADP-ribose binding site [chemical binding]; other site
497978000910	active site
497978000911	nudix motif; other site
497978000912	metal binding site [ion binding]; metal-binding site
497978000913	thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284
497978000914	ThiC-associated domain; Region: ThiC-associated; pfam13667
497978000915	Thiamine biosynthesis protein ThiC [Coenzyme metabolism]; Region: ThiC; COG0422
497978000916	conjugal transfer protein TraV; Provisional; Region: PRK13733
497978000917	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
497978000918	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
497978000919	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
497978000920	EamA-like transporter family; Region: EamA; pfam00892
497978000921	type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844
497978000922	transcriptional regulator PhoU; Provisional; Region: PRK11115
497978000923	PhoU domain; Region: PhoU; pfam01895
497978000924	PhoU domain; Region: PhoU; pfam01895
497978000925	oxidative damage protection protein; Provisional; Region: PRK05408
497978000926	argininosuccinate lyase; Provisional; Region: PRK00855
497978000927	Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359
497978000928	active sites [active]
497978000929	tetramer interface [polypeptide binding]; other site
497978000930	Histidine kinase; Region: His_kinase; pfam06580
497978000931	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
497978000932	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
497978000933	active site
497978000934	phosphorylation site [posttranslational modification]
497978000935	intermolecular recognition site; other site
497978000936	dimerization interface [polypeptide binding]; other site
497978000937	LytTr DNA-binding domain; Region: LytTR; smart00850
497978000938	porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072
497978000939	Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494
497978000940	domain interfaces; other site
497978000941	active site
497978000942	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
497978000943	Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587
497978000944	active site
497978000945	heme biosynthesis-associated TPR protein; Region: TPR_hemY_coli; TIGR00540
497978000946	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
497978000947	active site
497978000948	H-NS histone family; Region: Histone_HNS; pfam00816
497978000949	Domain in histone-like proteins of HNS family; Region: HNS; smart00528
497978000950	Type II secretion system (T2SS), protein N; Region: T2SN; pfam01203
497978000951	type II secretion system protein C; Region: typeII_sec_gspC; TIGR01713
497978000952	Type IV pilus biogenesis; Region: Pilus_PilP; pfam11356
497978000953	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
497978000954	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
497978000955	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
497978000956	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
497978000957	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
497978000958	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
497978000959	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
497978000960	phosphopeptide binding site; other site
497978000961	phosphoglycolate phosphatase; Provisional; Region: PRK13222
497978000962	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
497978000963	motif II; other site
497978000964	anthranilate synthase component I; Provisional; Region: PRK13565
497978000965	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
497978000966	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
497978000967	elongation factor Tu; Reviewed; Region: PRK00049
497978000968	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
497978000969	G1 box; other site
497978000970	GEF interaction site [polypeptide binding]; other site
497978000971	GTP/Mg2+ binding site [chemical binding]; other site
497978000972	Switch I region; other site
497978000973	G2 box; other site
497978000974	G3 box; other site
497978000975	Switch II region; other site
497978000976	G4 box; other site
497978000977	G5 box; other site
497978000978	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
497978000979	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
497978000980	Antibiotic Binding Site [chemical binding]; other site
497978000981	preprotein translocase subunit SecE; Reviewed; Region: secE; PRK05740
497978000982	transcription antitermination protein NusG; Validated; Region: nusG; PRK05609
497978000983	Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891
497978000984	putative homodimer interface [polypeptide binding]; other site
497978000985	NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091
497978000986	heterodimer interface [polypeptide binding]; other site
497978000987	homodimer interface [polypeptide binding]; other site
497978000988	50S ribosomal protein L11; Validated; Region: rplK; PRK00140
497978000989	Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349
497978000990	23S rRNA interface [nucleotide binding]; other site
497978000991	L7/L12 interface [polypeptide binding]; other site
497978000992	putative thiostrepton binding site; other site
497978000993	L25 interface [polypeptide binding]; other site
497978000994	Ribosomal protein L1.  The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA.  In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403
497978000995	mRNA/rRNA interface [nucleotide binding]; other site
497978000996	Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797
497978000997	23S rRNA interface [nucleotide binding]; other site
497978000998	Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site
497978000999	Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387
497978001000	core dimer interface [polypeptide binding]; other site
497978001001	peripheral dimer interface [polypeptide binding]; other site
497978001002	L10 interface [polypeptide binding]; other site
497978001003	L11 interface [polypeptide binding]; other site
497978001004	putative EF-Tu interaction site [polypeptide binding]; other site
497978001005	putative EF-G interaction site [polypeptide binding]; other site
497978001006	DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405
497978001007	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585
497978001008	RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561
497978001009	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
497978001010	RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562
497978001011	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
497978001012	RPB1 interaction site [polypeptide binding]; other site
497978001013	RPB11 interaction site [polypeptide binding]; other site
497978001014	RPB10 interaction site [polypeptide binding]; other site
497978001015	RPB3 interaction site [polypeptide binding]; other site
497978001016	RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997
497978001017	DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086
497978001018	RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663
497978001019	RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983
497978001020	RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000
497978001021	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
497978001022	Rpb1 - Rpb6 interaction site [polypeptide binding]; other site
497978001023	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
497978001024	Rpb1 - Rpb6 interaction site [polypeptide binding]; other site
497978001025	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
497978001026	DNA binding site [nucleotide binding]
497978001027	Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site
497978001028	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
497978001029	active site 2 [active]
497978001030	active site 1 [active]
497978001031	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
497978001032	Putative serine esterase (DUF676); Region: DUF676; pfam05057
497978001033	Predicted permease [General function prediction only]; Region: COG2056
497978001034	Na+-H+ antiporter family; Region: Na_H_antiport_2; pfam13726
497978001035	Outer membrane protein W [Cell envelope biogenesis, outer membrane]; Region: OmpW; COG3047
497978001036	Protein of unknown function (DUF1311); Region: DUF1311; pfam07007
497978001037	heat shock protein 90; Provisional; Region: PRK05218
497978001038	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
497978001039	ATP binding site [chemical binding]; other site
497978001040	Mg2+ binding site [ion binding]; other site
497978001041	G-X-G motif; other site
497978001042	Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761
497978001043	DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024
497978001044	catalytic residues [active]
497978001045	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
497978001046	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
497978001047	DNA binding residues [nucleotide binding]
497978001048	Predicted esterase of the alpha/beta hydrolase fold [General function prediction only]; Region: COG3545
497978001049	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
497978001050	hypothetical protein; Provisional; Region: PRK10215
497978001051	3-ketoacyl-CoA thiolase; Reviewed; Region: fadA; PRK08947
497978001052	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
497978001053	dimer interface [polypeptide binding]; other site
497978001054	active site
497978001055	multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadB; PRK11730
497978001056	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
497978001057	substrate binding site [chemical binding]; other site
497978001058	oxyanion hole (OAH) forming residues; other site
497978001059	trimer interface [polypeptide binding]; other site
497978001060	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
497978001061	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
497978001062	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
497978001063	Aspartyl/asparaginyl beta-hydroxylase and related dioxygenases [Posttranslational modification, protein turnover, chaperones]; Region: COG3555
497978001064	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220
497978001065	excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558
497978001066	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
497978001067	GIY-YIG motif/motif A; other site
497978001068	active site
497978001069	catalytic site [active]
497978001070	putative DNA binding site [nucleotide binding]; other site
497978001071	metal binding site [ion binding]; metal-binding site
497978001072	UvrB/uvrC motif; Region: UVR; pfam02151
497978001073	UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459
497978001074	Thioesterase-like superfamily; Region: 4HBT_3; pfam13622
497978001075	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445
497978001076	active site
497978001077	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II; cd00556
497978001078	active site
497978001079	dimer interface [polypeptide binding]; other site
497978001080	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453
497978001081	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
497978001082	Helix-turn-helix domain; Region: HTH_18; pfam12833
497978001083	Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350
497978001084	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
497978001085	DNA binding site [nucleotide binding]
497978001086	active site
497978001087	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_2; pfam13532
497978001088	IclR helix-turn-helix domain; Region: HTH_IclR; cl17605
497978001089	Transcriptional regulator [Transcription]; Region: IclR; COG1414
497978001090	Bacterial transcriptional regulator; Region: IclR; pfam01614
497978001091	Fusaric acid resistance protein family; Region: FUSC; pfam04632
497978001092	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
497978001093	Protein of unknown function (DUF1656); Region: DUF1656; pfam07869
497978001094	Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566
497978001095	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
497978001096	HlyD family secretion protein; Region: HlyD_3; pfam13437
497978001097	Holliday junction resolvase-like protein; Reviewed; Region: PRK00109
497978001098	Uncharacterized ACR, COG1678; Region: DUF179; pfam02622
497978001099	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497
497978001100	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
497978001101	Walker A/P-loop; other site
497978001102	ATP binding site [chemical binding]; other site
497978001103	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
497978001104	ABC transporter signature motif; other site
497978001105	Walker B; other site
497978001106	D-loop; other site
497978001107	H-loop/switch region; other site
497978001108	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
497978001109	binding surface
497978001110	Tetratricopeptide repeat; Region: TPR_16; pfam13432
497978001111	TPR motif; other site
497978001112	Protein of unknown function (DUF1255); Region: DUF1255; pfam06865
497978001113	23S rRNA (guanosine-2'-O-)-methyltransferase; Provisional; Region: PRK11181
497978001114	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032
497978001115	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
497978001116	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
497978001117	EamA-like transporter family; Region: EamA; pfam00892
497978001118	Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237
497978001119	Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022
497978001120	CoA-binding site [chemical binding]; other site
497978001121	ATP-binding [chemical binding]; other site
497978001122	Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989
497978001123	Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750
497978001124	Type IV leader peptidase family; Region: Peptidase_A24; pfam01478
497978001125	Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459
497978001126	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
497978001127	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
497978001128	type IV-A pilus assembly ATPase PilB; Region: type_IV_pilB; TIGR02538
497978001129	Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157
497978001130	PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129
497978001131	Walker A motif; other site
497978001132	ATP binding site [chemical binding]; other site
497978001133	Walker B motif; other site
497978001134	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
497978001135	triosephosphate isomerase; Provisional; Region: PRK14567
497978001136	substrate binding site [chemical binding]; other site
497978001137	dimer interface [polypeptide binding]; other site
497978001138	catalytic triad [active]
497978001139	Preprotein translocase SecG subunit; Region: SecG; pfam03840
497978001140	Sm and related proteins; Region: Sm_like; cl00259
497978001141	ribosome maturation protein RimP; Reviewed; Region: PRK00092
497978001142	Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734
497978001143	putative oligomer interface [polypeptide binding]; other site
497978001144	putative RNA binding site [nucleotide binding]; other site
497978001145	transcription elongation factor NusA; Validated; Region: nusA; PRK09202
497978001146	NusA N-terminal domain; Region: NusA_N; pfam08529
497978001147	S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455
497978001148	RNA binding site [nucleotide binding]; other site
497978001149	homodimer interface [polypeptide binding]; other site
497978001150	NusA-like KH domain; Region: KH_5; pfam13184
497978001151	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
497978001152	G-X-X-G motif; other site
497978001153	transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954
497978001154	transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954
497978001155	translation initiation factor IF-2; Region: IF-2; TIGR00487
497978001156	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
497978001157	Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887
497978001158	G1 box; other site
497978001159	putative GEF interaction site [polypeptide binding]; other site
497978001160	GTP/Mg2+ binding site [chemical binding]; other site
497978001161	Switch I region; other site
497978001162	G2 box; other site
497978001163	G3 box; other site
497978001164	Switch II region; other site
497978001165	G4 box; other site
497978001166	G5 box; other site
497978001167	This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702
497978001168	Translation-initiation factor 2; Region: IF-2; pfam11987
497978001169	mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692
497978001170	ribosome-binding factor A; Provisional; Region: PRK13816
497978001171	putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12674
497978001172	Multiple resistance and pH regulation protein F (MrpF / PhaF); Region: MrpF_PhaF; cl09154
497978001173	putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12666
497978001174	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
497978001175	putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK09094
497978001176	putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12648
497978001177	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
497978001178	Domain of unknown function (DUF4040); Region: DUF4040; pfam13244
497978001179	Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111
497978001180	putative monovalent cation/H+ antiporter subunit B; Reviewed; Region: PRK12573
497978001181	AAA domain; Region: AAA_23; pfam13476
497978001182	Family description; Region: UvrD_C_2; pfam13538
497978001183	bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759
497978001184	phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051
497978001185	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534
497978001186	metal binding site [ion binding]; metal-binding site
497978001187	2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654
497978001188	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
497978001189	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
497978001190	ABC1 family; Region: ABC1; cl17513
497978001191	2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982
497978001192	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3165
497978001193	Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226
497978001194	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
497978001195	S-adenosylmethionine binding site [chemical binding]; other site
497978001196	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4627
497978001197	Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971
497978001198	polyphosphate:AMP phosphotransferase; Region: poly_P_AMP_trns; TIGR03708
497978001199	Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971
497978001200	Uncharacterized protein/domain associated with GTPases [Function unknown]; Region: COG3597
497978001201	Exodeoxyribonuclease V, gamma subunit; Region: Exonuc_V_gamma; pfam04257
497978001202	exonuclease V subunit gamma; Provisional; Region: recC; PRK11069
497978001203	Part of AAA domain; Region: AAA_19; pfam13245
497978001204	ATP-dependent exoDNAse (exonuclease V) beta subunit (contains helicase and exonuclease domains) [DNA replication, recombination, and repair]; Region: RecB; COG1074
497978001205	Family description; Region: UvrD_C_2; pfam13538
497978001206	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
497978001207	AAA domain; Region: AAA_30; pfam13604
497978001208	AAA domain; Region: AAA_22; pfam13401
497978001209	Family description; Region: UvrD_C_2; pfam13538
497978001210	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
497978001211	Beta-lactamase; Region: Beta-lactamase; pfam00144
497978001212	Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353
497978001213	16S/18S rRNA binding site [nucleotide binding]; other site
497978001214	S13e-L30e interaction site [polypeptide binding]; other site
497978001215	25S rRNA binding site [nucleotide binding]; other site
497978001216	polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824
497978001217	Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363
497978001218	RNase E interface [polypeptide binding]; other site
497978001219	trimer interface [polypeptide binding]; other site
497978001220	Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726
497978001221	Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364
497978001222	RNase E interface [polypeptide binding]; other site
497978001223	trimer interface [polypeptide binding]; other site
497978001224	active site
497978001225	Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393
497978001226	putative nucleic acid binding region [nucleotide binding]; other site
497978001227	G-X-X-G motif; other site
497978001228	S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase  is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472
497978001229	RNA binding site [nucleotide binding]; other site
497978001230	domain interface; other site
497978001231	CorA-like Mg2+ transporter protein; Region: CorA; pfam01544
497978001232	Thermotoga maritima CorA-like family; Region: TmCorA-like; cd12822
497978001233	oligomer interface [polypeptide binding]; other site
497978001234	metal binding site [ion binding]; metal-binding site
497978001235	metal binding site [ion binding]; metal-binding site
497978001236	putative Cl binding site [ion binding]; other site
497978001237	aspartate ring; other site
497978001238	basic sphincter; other site
497978001239	hydrophobic gate; other site
497978001240	periplasmic entrance; other site
497978001241	MerR HTH family regulatory protein; Region: MerR_2; pfam13591
497978001242	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
497978001243	chaperone protein DnaJ; Region: DnaJ_bact; TIGR02349
497978001244	HSP70 interaction site [polypeptide binding]; other site
497978001245	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
497978001246	substrate binding site [polypeptide binding]; other site
497978001247	dimer interface [polypeptide binding]; other site
497978001248	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
497978001249	Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114
497978001250	Heat shock protein 33 (Hsp33):  Cytosolic protein that acts as a molecular chaperone under oxidative conditions.  In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498
497978001251	dimerization interface [polypeptide binding]; other site
497978001252	domain crossover interface; other site
497978001253	redox-dependent activation switch; other site
497978001254	glutathione-regulated potassium-efflux system protein KefC; Provisional; Region: PRK03562
497978001255	transporter, monovalent cation:proton antiporter-2 (CPA2) family; Region: 2a37; TIGR00932
497978001256	TrkA-N domain; Region: TrkA_N; pfam02254
497978001257	primosome assembly protein PriA; Validated; Region: PRK05580
497978001258	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
497978001259	ATP binding site [chemical binding]; other site
497978001260	putative Mg++ binding site [ion binding]; other site
497978001261	helicase superfamily c-terminal domain; Region: HELICc; smart00490
497978001262	ATP-binding site [chemical binding]; other site
497978001263	type II secretion system protein F; Region: GspF; TIGR02120
497978001264	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
497978001265	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
497978001266	type II secretion system protein G; Region: typeII_sec_gspG; TIGR01710
497978001267	Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334
497978001268	tRNA-binding-domain-containing CsaA-like proteins. CsaA is a molecular chaperone with export related activities. CsaA has a putative tRNA binding activity. The functional unit of CsaA is a homodimer and this domain acts as a dimerization domain; Region: tRNA_bind_CsaA; cd02798
497978001269	dimer interface [polypeptide binding]; other site
497978001270	putative tRNA-binding site [nucleotide binding]; other site
497978001271	apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302
497978001272	Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571
497978001273	putative active site [active]
497978001274	catalytic triad [active]
497978001275	putative dimer interface [polypeptide binding]; other site
497978001276	FOG: CBS domain [General function prediction only]; Region: COG0517
497978001277	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
497978001278	Transporter associated domain; Region: CorC_HlyC; smart01091
497978001279	SirA (also known as UvrY,  and YhhP) belongs to a family of two-component response regulators that controls secondary metabolism and virulence. The other member of this two-component system is a sensor kinase called BarA which phosphorylates SirA.  A...; Region: SirA; cd03423
497978001280	CPxP  motif; other site
497978001281	Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644
497978001282	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
497978001283	Electron transfer flavoprotein-ubiquinone oxidoreductase; Region: ETF_QO; pfam05187
497978001284	Ferredoxin-like protein [Energy production and conversion]; Region: FixX; COG2440
497978001285	Protein of unknown function (DUF1285); Region: DUF1285; pfam06938
497978001286	glutamate racemase; Provisional; Region: PRK00865
497978001287	aspartate racemase; Region: asp_race; TIGR00035
497978001288	Domain of unknown function (DUF4062); Region: DUF4062; pfam13271
497978001289	ferrochelatase; Reviewed; Region: hemH; PRK00035
497978001290	Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411
497978001291	C-terminal domain interface [polypeptide binding]; other site
497978001292	active site
497978001293	Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419
497978001294	active site
497978001295	N-terminal domain interface [polypeptide binding]; other site
497978001296	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
497978001297	Domain of unknown function (DUF329); Region: DUF329; pfam03884
497978001298	Putative methyltransferase; Region: Methyltransf_4; cl17290
497978001299	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
497978001300	uncharacterized flavoprotein, PP_4765 family; Region: flavo_PP4765; TIGR03862
497978001301	Glutathione-dependent formaldehyde-activating enzyme; Region: GFA; pfam04828
497978001302	chromosome condensation membrane protein; Provisional; Region: PRK14196
497978001303	HopJ type III effector protein; Region: HopJ; pfam08888
497978001304	50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678
497978001305	Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661
497978001306	ABC1 family; Region: ABC1; pfam03109
497978001307	sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022
497978001308	Dibenzothiophene (DBT) desulfurization enzyme C; Region: DszC; cd01163
497978001309	Flavin binding site [chemical binding]; other site
497978001310	Dibenzothiophene (DBT) desulfurization enzyme C; Region: DszC; cd01163
497978001311	sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022
497978001312	Flavin binding site [chemical binding]; other site
497978001313	multidrug efflux protein; Reviewed; Region: PRK01766
497978001314	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131
497978001315	cation binding site [ion binding]; other site
497978001316	Protein of unknown function, DUF606; Region: DUF606; pfam04657
497978001317	HemN family oxidoreductase; Provisional; Region: PRK05660
497978001318	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
497978001319	FeS/SAM binding site; other site
497978001320	HemN C-terminal domain; Region: HemN_C; pfam06969
497978001321	short chain dehydrogenase; Provisional; Region: PRK12744
497978001322	tetrahydroxynaphthalene/trihydroxynaphthalene reductase-like, classical (c) SDRs; Region: THN_reductase-like_SDR_c; cd05362
497978001323	NADP binding site [chemical binding]; other site
497978001324	homodimer interface [polypeptide binding]; other site
497978001325	active site
497978001326	substrate binding site [chemical binding]; other site
497978001327	Transcriptional regulator [Transcription]; Region: LysR; COG0583
497978001328	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
497978001329	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472
497978001330	putative effector binding pocket; other site
497978001331	putative dimerization interface [polypeptide binding]; other site
497978001332	long-chain-acyl-CoA synthetase; Validated; Region: PRK08279
497978001333	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
497978001334	Fatty acid transport proteins (FATP) play dual roles as fatty acid transporters and its activation enzymes; Region: FATP_FACS; cd05940
497978001335	acyl-activating enzyme (AAE) consensus motif; other site
497978001336	putative AMP binding site [chemical binding]; other site
497978001337	putative active site [active]
497978001338	putative CoA binding site [chemical binding]; other site
497978001339	Ribonucleases G and E [Translation, ribosomal structure and biogenesis]; Region: CafA; COG1530
497978001340	S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453
497978001341	homodimer interface [polypeptide binding]; other site
497978001342	oligonucleotide binding site [chemical binding]; other site
497978001343	23S rRNA pseudouridylate synthase C; Provisional; Region: PRK11025
497978001344	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
497978001345	RNA binding surface [nucleotide binding]; other site
497978001346	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
497978001347	active site
497978001348	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
497978001349	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
497978001350	motif II; other site
497978001351	Predicted transcriptional regulator [Transcription]; Region: COG2378
497978001352	HTH domain; Region: HTH_11; pfam08279
497978001353	WYL domain; Region: WYL; pfam13280
497978001354	GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972
497978001355	GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046
497978001356	putative C-terminal domain interface [polypeptide binding]; other site
497978001357	putative GSH binding site (G-site) [chemical binding]; other site
497978001358	putative dimer interface [polypeptide binding]; other site
497978001359	C-terminal, alpha helical domain of an unknown subfamily 8 of Glutathione S-transferases; Region: GST_C_8; cd03207
497978001360	dimer interface [polypeptide binding]; other site
497978001361	N-terminal domain interface [polypeptide binding]; other site
497978001362	putative substrate binding pocket (H-site) [chemical binding]; other site
497978001363	Protein of unknown function (DUF1345); Region: DUF1345; pfam07077
497978001364	DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906
497978001365	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
497978001366	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
497978001367	dimerization interface [polypeptide binding]; other site
497978001368	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
497978001369	Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706
497978001370	catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061
497978001371	Heme-dependent peroxidases similar to plant peroxidases; Region: plant_peroxidase_like; cl00196
497978001372	heme binding site [chemical binding]; other site
497978001373	C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200
497978001374	Signal transduction protein containing GAF and PtsI domains [Signal transduction mechanisms]; Region: PtsP; COG3605
497978001375	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
497978001376	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
497978001377	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
497978001378	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
497978001379	Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671
497978001380	putative active site [active]
497978001381	Ap4A binding site [chemical binding]; other site
497978001382	nudix motif; other site
497978001383	putative metal binding site [ion binding]; other site
497978001384	Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560
497978001385	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
497978001386	Transcriptional regulator [Transcription]; Region: LysR; COG0583
497978001387	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
497978001388	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
497978001389	dimerization interface [polypeptide binding]; other site
497978001390	Predicted membrane protein (DUF2061); Region: DUF2061; pfam09834
497978001391	3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402
497978001392	3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583
497978001393	substrate binding site [chemical binding]; other site
497978001394	ligand binding site [chemical binding]; other site
497978001395	isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641
497978001396	Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577
497978001397	substrate binding site [chemical binding]; other site
497978001398	tartrate dehydrogenase; Region: TTC; TIGR02089
497978001399	3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772
497978001400	Protein of unknown function (DUF1311); Region: DUF1311; cl01530
497978001401	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
497978001402	rRNA binding site [nucleotide binding]; other site
497978001403	predicted 30S ribosome binding site; other site
497978001404	Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625
497978001405	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
497978001406	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
497978001407	tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021
497978001408	Eukaryotic and bacterial pseudouridine synthases similar to E.  coli TruA; Region: PseudoU_synth_EcTruA; cd02570
497978001409	dimerization interface 3.5A [polypeptide binding]; other site
497978001410	active site
497978001411	Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963
497978001412	active site
497978001413	homodimer interface [polypeptide binding]; other site
497978001414	FimV N-terminal domain; Region: FimV_core; TIGR03505
497978001415	aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK06598
497978001416	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
497978001417	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
497978001418	putative catalytic site [active]
497978001419	putative metal binding site [ion binding]; other site
497978001420	putative phosphate binding site [ion binding]; other site
497978001421	glutamate/aspartate:proton symporter; Provisional; Region: gltP; PRK11283
497978001422	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
497978001423	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
497978001424	This family is most closely related to the GT1 family of glycosyltransferases. WavL in Vibrio cholerae has been shown to be involved in the biosynthesis of the lipopolysaccharide core; Region: GT1_WavL_like; cd03819
497978001425	putative ADP-binding pocket [chemical binding]; other site
497978001426	Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279
497978001427	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
497978001428	putative acyl-acceptor binding pocket; other site
497978001429	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
497978001430	ABC transporter ATPase component; Reviewed; Region: PRK11147
497978001431	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
497978001432	Walker A/P-loop; other site
497978001433	ATP binding site [chemical binding]; other site
497978001434	Q-loop/lid; other site
497978001435	ABC transporter signature motif; other site
497978001436	Walker B; other site
497978001437	D-loop; other site
497978001438	H-loop/switch region; other site
497978001439	ABC transporter; Region: ABC_tran_2; pfam12848
497978001440	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
497978001441	SlyX; Region: SlyX; pfam04102
497978001442	Arginate lyase and other MDR family members; Region: AL_MDR; cd08252
497978001443	zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817
497978001444	putative NAD(P) binding site [chemical binding]; other site
497978001445	dimer interface [polypeptide binding]; other site
497978001446	Predicted transcriptional regulators [Transcription]; Region: COG1733
497978001447	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
497978001448	Ammonium Transporter Family; Region: Ammonium_transp; cl03012
497978001449	DNA topoisomerase I subunit omega; Validated; Region: PRK07561
497978001450	TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I.   Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363
497978001451	active site
497978001452	interdomain interaction site; other site
497978001453	putative metal-binding site [ion binding]; other site
497978001454	nucleotide binding site [chemical binding]; other site
497978001455	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
497978001456	domain I; other site
497978001457	DNA binding groove [nucleotide binding]
497978001458	phosphate binding site [ion binding]; other site
497978001459	domain II; other site
497978001460	domain III; other site
497978001461	nucleotide binding site [chemical binding]; other site
497978001462	catalytic site [active]
497978001463	domain IV; other site
497978001464	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
497978001465	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
497978001466	Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272
497978001467	Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272
497978001468	Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247
497978001469	Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
497978001470	Part of AAA domain; Region: AAA_19; pfam13245
497978001471	Family description; Region: UvrD_C_2; pfam13538
497978001472	RNA-binding proteins (RRM domain) [General function prediction only]; Region: COG0724
497978001473	RNA recognition motif; Region: RRM; smart00360
497978001474	ASC-1 homology or ASCH domain, a small beta-barrel domain found in all three kingdoms of life. ASCH resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as an RNA-binding domain during coactivation; Region: ASCH; cl01020
497978001475	putative cation:proton antiport protein; Provisional; Region: PRK10669
497978001476	Kef-type K+ transport system, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: RosB; COG4651
497978001477	TrkA-N domain; Region: TrkA_N; pfam02254
497978001478	50S ribosomal protein L33; Validated; Region: rpmG; PRK00595
497978001479	50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359
497978001480	aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381
497978001481	Coniferyl aldehyde dehydrogenase-like; Region: ALDH_CALDH_CalB; cd07133
497978001482	NAD(P) binding site [chemical binding]; other site
497978001483	catalytic residues [active]
497978001484	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
497978001485	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
497978001486	Bacterial transcriptional repressor; Region: TetR; pfam13972
497978001487	formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027
497978001488	N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875
497978001489	Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648
497978001490	putative active site [active]
497978001491	putative substrate binding site [chemical binding]; other site
497978001492	putative cosubstrate binding site; other site
497978001493	catalytic site [active]
497978001494	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
497978001495	Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811
497978001496	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
497978001497	Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472
497978001498	methionine sulfoxide reductase A; Provisional; Region: PRK14054
497978001499	Domain of unknown function (DUF4105); Region: DUF4105; pfam13387
497978001500	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
497978001501	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209
497978001502	folate binding site [chemical binding]; other site
497978001503	NADP+ binding site [chemical binding]; other site
497978001504	thymidylate synthase; Reviewed; Region: thyA; PRK01827
497978001505	Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351
497978001506	dimerization interface [polypeptide binding]; other site
497978001507	active site
497978001508	prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK12437
497978001509	NRDE protein; Region: NRDE; cl01315
497978001510	Predicted phosphatase [General function prediction only]; Region: PhoX; COG3211
497978001511	Bacterial protein of unknown function (DUF839); Region: DUF839; pfam05787
497978001512	Sec-independent protein translocase protein (TatC); Region: TatC; cl00521
497978001513	twin arginine-targeting protein translocase TatB; Region: tatB; TIGR01410
497978001514	mttA/Hcf106 family; Region: MttA_Hcf106; cl00788
497978001515	Membrane transport protein; Region: Mem_trans; cl09117
497978001516	NTPase/HAM1.  This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515
497978001517	active site
497978001518	dimerization interface [polypeptide binding]; other site
497978001519	Sel1-like repeats; Region: SEL1; smart00671
497978001520	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
497978001521	Sel1-like repeats; Region: SEL1; smart00671
497978001522	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
497978001523	S-adenosylmethionine binding site [chemical binding]; other site
497978001524	homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175
497978001525	homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392
497978001526	2-isopropylmalate synthase; Validated; Region: PRK03739
497978001527	Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942
497978001528	active site
497978001529	catalytic residues [active]
497978001530	metal binding site [ion binding]; metal-binding site
497978001531	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917
497978001532	Fe(II)-dependent oxygenase superfamily protein; Provisional; Region: PRK05467
497978001533	Outer membrane receptor for monomeric catechols [Inorganic ion transport and metabolism]; Region: Fiu; COG4774
497978001534	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
497978001535	N-terminal plug; other site
497978001536	ligand-binding site [chemical binding]; other site
497978001537	trigger factor; Provisional; Region: tig; PRK01490
497978001538	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
497978001539	Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698
497978001540	Clp protease; Region: CLP_protease; pfam00574
497978001541	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
497978001542	oligomer interface [polypeptide binding]; other site
497978001543	active site residues [active]
497978001544	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
497978001545	ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689
497978001546	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
497978001547	Walker A motif; other site
497978001548	ATP binding site [chemical binding]; other site
497978001549	Walker B motif; other site
497978001550	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
497978001551	Protein of unknown function (DUF2846); Region: DUF2846; pfam11008
497978001552	Uncharacterized protein conserved in bacteria (DUF2059); Region: DUF2059; pfam09832
497978001553	Fumarate hydratase (Fumerase); Region: Fumerase; pfam05681
497978001554	Fumarase C-terminus; Region: Fumerase_C; pfam05683
497978001555	phosphate acetyltransferase; Reviewed; Region: PRK05632
497978001556	DRTGG domain; Region: DRTGG; pfam07085
497978001557	phosphotransacetylase; Reviewed; Region: eutD; PRK09653
497978001558	propionate/acetate kinase; Provisional; Region: PRK12379
497978001559	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
497978001560	nucleotide binding site [chemical binding]; other site
497978001561	Butyrate kinase [Energy production and conversion]; Region: COG3426
497978001562	phosphogluconate dehydratase; Validated; Region: PRK09054
497978001563	6-phosphogluconate dehydratase; Region: edd; TIGR01196
497978001564	keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718
497978001565	KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452
497978001566	active site
497978001567	intersubunit interface [polypeptide binding]; other site
497978001568	catalytic residue [active]
497978001569	GntP family permease; Region: GntP_permease; pfam02447
497978001570	fructuronate transporter; Provisional; Region: PRK10034; cl15264
497978001571	Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021
497978001572	ATP-binding site [chemical binding]; other site
497978001573	Gluconate-6-phosphate binding site [chemical binding]; other site
497978001574	Shikimate kinase; Region: SKI; pfam01202
497978001575	NADP+-dependent non-phosphorylating glyceraldehyde 3-phosphate dehydrogenase and ALDH family 11; Region: ALDH_F11_NP-GAPDH; cd07082
497978001576	NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012
497978001577	tetrameric interface [polypeptide binding]; other site
497978001578	activator binding site; other site
497978001579	NADP binding site [chemical binding]; other site
497978001580	substrate binding site [chemical binding]; other site
497978001581	catalytic residues [active]
497978001582	Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079
497978001583	gamma-glutamyl phosphate reductase; Region: proA; TIGR00407
497978001584	putative catalytic cysteine [active]
497978001585	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
497978001586	Leucine carboxyl methyltransferase; Region: LCM; pfam04072
497978001587	beta-hexosaminidase; Provisional; Region: PRK05337
497978001588	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
497978001589	carboxy-terminal protease; Provisional; Region: PRK11186
497978001590	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
497978001591	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
497978001592	protein binding site [polypeptide binding]; other site
497978001593	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
497978001594	Catalytic dyad [active]
497978001595	C-terminal domain of tail specific protease (DUF3340); Region: DUF3340; pfam11818
497978001596	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
497978001597	This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814
497978001598	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
497978001599	PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610
497978001600	active site
497978001601	Iron-sulphur cluster assembly; Region: Fe-S_assembly; pfam04384
497978001602	Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413
497978001603	active site
497978001604	multimer interface [polypeptide binding]; other site
497978001605	ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK11194
497978001606	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
497978001607	FeS/SAM binding site; other site
497978001608	type IV pilus biogenesis/stability protein PilW; Region: type_IV_pilW; TIGR02521
497978001609	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
497978001610	TPR motif; other site
497978001611	binding surface
497978001612	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
497978001613	TPR motif; other site
497978001614	binding surface
497978001615	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
497978001616	binding surface
497978001617	TPR motif; other site
497978001618	Helix-turn-helix domain; Region: HTH_25; pfam13413
497978001619	Domain of unknown function (DUF4115); Region: DUF4115; pfam13464
497978001620	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366
497978001621	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
497978001622	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
497978001623	histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037
497978001624	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
497978001625	dimer interface [polypeptide binding]; other site
497978001626	motif 1; other site
497978001627	active site
497978001628	motif 2; other site
497978001629	motif 3; other site
497978001630	HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859
497978001631	anticodon binding site; other site
497978001632	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2976
497978001633	Uncharacterized protein conserved in bacteria (DUF2133); Region: DUF2133; pfam09976
497978001634	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
497978001635	TPR motif; other site
497978001636	binding surface
497978001637	outer membrane assembly lipoprotein YfgL; Region: assembly_YfgL; TIGR03300
497978001638	PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493
497978001639	Trp docking motif [polypeptide binding]; other site
497978001640	active site
497978001641	GTP-binding protein Der; Reviewed; Region: PRK00093
497978001642	EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894
497978001643	G1 box; other site
497978001644	GTP/Mg2+ binding site [chemical binding]; other site
497978001645	Switch I region; other site
497978001646	G2 box; other site
497978001647	Switch II region; other site
497978001648	G3 box; other site
497978001649	G4 box; other site
497978001650	G5 box; other site
497978001651	EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895
497978001652	G1 box; other site
497978001653	GTP/Mg2+ binding site [chemical binding]; other site
497978001654	Switch I region; other site
497978001655	G2 box; other site
497978001656	G3 box; other site
497978001657	Switch II region; other site
497978001658	G4 box; other site
497978001659	G5 box; other site
497978001660	Beta-ketoacyl synthase, N-terminal domain; Region: Ketoacyl-synt_2; pfam13723
497978001661	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
497978001662	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
497978001663	putative acyl-acceptor binding pocket; other site
497978001664	Phosphopantetheine attachment site; Region: PP-binding; cl09936
497978001665	acyl carrier protein; Provisional; Region: PRK05350
497978001666	Predicted membrane protein [Function unknown]; Region: COG4648
497978001667	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
497978001668	Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365
497978001669	acyl-activating enzyme (AAE) consensus motif; other site
497978001670	active site
497978001671	AMP binding site [chemical binding]; other site
497978001672	CoA binding site [chemical binding]; other site
497978001673	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
497978001674	active site 2 [active]
497978001675	active site 1 [active]
497978001676	DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179
497978001677	Ligand binding site; other site
497978001678	Putative Catalytic site; other site
497978001679	DXD motif; other site
497978001680	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
497978001681	putative acyl-acceptor binding pocket; other site
497978001682	Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332
497978001683	active sites [active]
497978001684	tetramer interface [polypeptide binding]; other site
497978001685	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
497978001686	active site
497978001687	Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl17548
497978001688	Predicted exporter [General function prediction only]; Region: COG4258
497978001689	Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644
497978001690	3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK09185
497978001691	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
497978001692	dimer interface [polypeptide binding]; other site
497978001693	active site
497978001694	Domain of unknown function, appears to be related to a diverse group of beta-hydroxydecanoyl ACP dehydratases (FabA) and beta-hydroxyacyl ACP dehydratases (FabZ). This group appears to lack the conserved active site histidine of FabA and FabZ; Region: FabA_like; cd01289
497978001695	putative active site 1 [active]
497978001696	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
497978001697	3-oxoacyl-(acyl-carrier-protein) reductase, putative; Region: fabG_rel; TIGR01831
497978001698	NAD(P) binding site [chemical binding]; other site
497978001699	homotetramer interface [polypeptide binding]; other site
497978001700	homodimer interface [polypeptide binding]; other site
497978001701	active site
497978001702	3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK09116
497978001703	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
497978001704	dimer interface [polypeptide binding]; other site
497978001705	active site
497978001706	Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091
497978001707	4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648
497978001708	preprotein translocase subunit SecB; Validated; Region: PRK05751
497978001709	SecA binding site; other site
497978001710	Preprotein binding site; other site
497978001711	Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418
497978001712	GSH binding site [chemical binding]; other site
497978001713	catalytic residues [active]
497978001714	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
497978001715	active site residue [active]
497978001716	GTPase RsgA; Reviewed; Region: PRK12288
497978001717	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
497978001718	RNA binding site [nucleotide binding]; other site
497978001719	Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854
497978001720	GTPase/Zn-binding domain interface [polypeptide binding]; other site
497978001721	GTP/Mg2+ binding site [chemical binding]; other site
497978001722	G4 box; other site
497978001723	G5 box; other site
497978001724	G1 box; other site
497978001725	Switch I region; other site
497978001726	G2 box; other site
497978001727	G3 box; other site
497978001728	Switch II region; other site
497978001729	DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135
497978001730	catalytic site [active]
497978001731	putative active site [active]
497978001732	putative substrate binding site [chemical binding]; other site
497978001733	dimer interface [polypeptide binding]; other site
497978001734	Bax inhibitor 1 like; Region: BaxI_1; cl17691
497978001735	Enoyl-[acyl-carrier-protein]; Region: FabI; COG0623
497978001736	Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372
497978001737	NAD binding site [chemical binding]; other site
497978001738	homotetramer interface [polypeptide binding]; other site
497978001739	homodimer interface [polypeptide binding]; other site
497978001740	substrate binding site [chemical binding]; other site
497978001741	active site
497978001742	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
497978001743	macrolide transporter ATP-binding /permease protein; Provisional; Region: PRK10535
497978001744	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
497978001745	Walker A/P-loop; other site
497978001746	ATP binding site [chemical binding]; other site
497978001747	Q-loop/lid; other site
497978001748	ABC transporter signature motif; other site
497978001749	Walker B; other site
497978001750	D-loop; other site
497978001751	H-loop/switch region; other site
497978001752	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
497978001753	FtsX-like permease family; Region: FtsX; pfam02687
497978001754	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
497978001755	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
497978001756	HlyD family secretion protein; Region: HlyD_3; pfam13437
497978001757	DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574
497978001758	DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144
497978001759	Lipopolysaccharide-assembly; Region: LptE; pfam04390
497978001760	leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390
497978001761	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
497978001762	HIGH motif; other site
497978001763	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
497978001764	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
497978001765	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
497978001766	active site
497978001767	KMSKS motif; other site
497978001768	Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958
497978001769	tRNA binding surface [nucleotide binding]; other site
497978001770	Domain of unknown function (DUF4124); Region: DUF4124; pfam13511
497978001771	acetolactate synthase 3 catalytic subunit; Validated; Region: PRK06466
497978001772	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
497978001773	PYR/PP interface [polypeptide binding]; other site
497978001774	dimer interface [polypeptide binding]; other site
497978001775	TPP binding site [chemical binding]; other site
497978001776	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
497978001777	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
497978001778	TPP-binding site [chemical binding]; other site
497978001779	dimer interface [polypeptide binding]; other site
497978001780	acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895
497978001781	N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878
497978001782	putative valine binding site [chemical binding]; other site
497978001783	dimer interface [polypeptide binding]; other site
497978001784	Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369
497978001785	ketol-acid reductoisomerase; Provisional; Region: PRK05479
497978001786	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991
497978001787	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450
497978001788	MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300
497978001789	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
497978001790	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
497978001791	metal binding site [ion binding]; metal-binding site
497978001792	active site
497978001793	I-site; other site
497978001794	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
497978001795	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
497978001796	transcriptional repressor BetI; Region: betaine_BetI; TIGR03384
497978001797	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
497978001798	peptide chain release factor 3; Provisional; Region: prfC; PRK00741
497978001799	Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169
497978001800	G1 box; other site
497978001801	putative GEF interaction site [polypeptide binding]; other site
497978001802	GTP/Mg2+ binding site [chemical binding]; other site
497978001803	Switch I region; other site
497978001804	G2 box; other site
497978001805	G3 box; other site
497978001806	Switch II region; other site
497978001807	G4 box; other site
497978001808	G5 box; other site
497978001809	RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689
497978001810	Protein of unknown function (DUF3298); Region: DUF3298; pfam11738
497978001811	Domain of unknown function (DUF4163); Region: DUF4163; pfam13739
497978001812	Protein of unknown function (DUF3298); Region: DUF3298; pfam11738
497978001813	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
497978001814	active site
497978001815	aconitate hydratase; Validated; Region: PRK09277
497978001816	Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285
497978001817	substrate binding site [chemical binding]; other site
497978001818	ligand binding site [chemical binding]; other site
497978001819	Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580
497978001820	substrate binding site [chemical binding]; other site
497978001821	This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function.  The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199
497978001822	homotrimer interaction site [polypeptide binding]; other site
497978001823	putative active site [active]
497978001824	Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179
497978001825	Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755
497978001826	putative ATP binding site [chemical binding]; other site
497978001827	putative substrate interface [chemical binding]; other site
497978001828	Transcriptional regulator [Transcription]; Region: LysR; COG0583
497978001829	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
497978001830	The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414
497978001831	dimerization interface [polypeptide binding]; other site
497978001832	substrate binding pocket [chemical binding]; other site
497978001833	tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815
497978001834	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
497978001835	FMN binding site [chemical binding]; other site
497978001836	active site
497978001837	catalytic residues [active]
497978001838	substrate binding site [chemical binding]; other site
497978001839	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
497978001840	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
497978001841	putative substrate translocation pore; other site
497978001842	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
497978001843	homotrimer interaction site [polypeptide binding]; other site
497978001844	putative active site [active]
497978001845	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
497978001846	EamA-like transporter family; Region: EamA; pfam00892
497978001847	EamA-like transporter family; Region: EamA; pfam00892
497978001848	Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304
497978001849	NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288
497978001850	ligand binding site [chemical binding]; other site
497978001851	homodimer interface [polypeptide binding]; other site
497978001852	NAD(P) binding site [chemical binding]; other site
497978001853	trimer interface B [polypeptide binding]; other site
497978001854	trimer interface A [polypeptide binding]; other site
497978001855	Domain of unknown function (DUF3814); Region: DUF3814; pfam12769
497978001856	NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233
497978001857	NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; COG1282
497978001858	retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327
497978001859	acetoacetyl-CoA reductase; Provisional; Region: PRK12935
497978001860	putative NAD(P) binding site [chemical binding]; other site
497978001861	active site
497978001862	iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090
497978001863	hydroxypyruvate isomerase; Region: OH-pyruv-isom; TIGR03234
497978001864	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
497978001865	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
497978001866	enoyl-CoA hydratase; Provisional; Region: PRK07509
497978001867	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
497978001868	substrate binding site [chemical binding]; other site
497978001869	oxyanion hole (OAH) forming residues; other site
497978001870	trimer interface [polypeptide binding]; other site
497978001871	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
497978001872	dimer interface [polypeptide binding]; other site
497978001873	phosphorylation site [posttranslational modification]
497978001874	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
497978001875	ATP binding site [chemical binding]; other site
497978001876	Mg2+ binding site [ion binding]; other site
497978001877	G-X-G motif; other site
497978001878	Response regulator receiver domain; Region: Response_reg; pfam00072
497978001879	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
497978001880	active site
497978001881	phosphorylation site [posttranslational modification]
497978001882	intermolecular recognition site; other site
497978001883	dimerization interface [polypeptide binding]; other site
497978001884	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086
497978001885	cysteine synthase B; Region: cysM; TIGR01138
497978001886	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
497978001887	dimer interface [polypeptide binding]; other site
497978001888	pyridoxal 5'-phosphate binding site [chemical binding]; other site
497978001889	catalytic residue [active]
497978001890	Uncharacterized bacterial subgroup of the DEDDy 3'-5' exonuclease domain of family-B DNA polymerases; Region: DNA_polB_like1_exo; cd05782
497978001891	active site
497978001892	catalytic site [active]
497978001893	substrate binding site [chemical binding]; other site
497978001894	Predicted 3'-5' exonuclease related to the exonuclease domain of PolB; Region: DNA_pol_B_exo2; pfam10108
497978001895	23S rRNA m(5)U1939 methyltransferase; Reviewed; Region: rumA; PRK13168
497978001896	TRAM domain; Region: TRAM; pfam01938
497978001897	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
497978001898	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
497978001899	S-adenosylmethionine binding site [chemical binding]; other site
497978001900	HD domain; Region: HD_4; pfam13328
497978001901	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
497978001902	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
497978001903	synthetase active site [active]
497978001904	NTP binding site [chemical binding]; other site
497978001905	metal binding site [ion binding]; metal-binding site
497978001906	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
497978001907	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
497978001908	short chain dehydrogenase; Provisional; Region: PRK08267
497978001909	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
497978001910	NAD(P) binding site [chemical binding]; other site
497978001911	active site
497978001912	nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562
497978001913	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528
497978001914	homodimer interface [polypeptide binding]; other site
497978001915	metal binding site [ion binding]; metal-binding site
497978001916	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529
497978001917	homodimer interface [polypeptide binding]; other site
497978001918	active site
497978001919	putative chemical substrate binding site [chemical binding]; other site
497978001920	metal binding site [ion binding]; metal-binding site
497978001921	DNA uptake protein and related DNA-binding proteins [DNA replication, recombination, and repair]; Region: ComEA; COG1555
497978001922	Helix-hairpin-helix motif; Region: HHH; pfam00633
497978001923	poly(A) polymerase; Region: pcnB; TIGR01942
497978001924	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
497978001925	active site
497978001926	NTP binding site [chemical binding]; other site
497978001927	metal binding triad [ion binding]; metal-binding site
497978001928	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
497978001929	Polymerase A arginine-rich C-terminus; Region: PolyA_pol_arg_C; pfam12626
497978001930	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483
497978001931	catalytic center binding site [active]
497978001932	ATP binding site [chemical binding]; other site
497978001933	Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557
497978001934	oligomerization interface [polypeptide binding]; other site
497978001935	active site
497978001936	metal binding site [ion binding]; metal-binding site
497978001937	pantoate--beta-alanine ligase; Region: panC; TIGR00018
497978001938	Pantoate-beta-alanine ligase; Region: PanC; cd00560
497978001939	active site
497978001940	ATP-binding site [chemical binding]; other site
497978001941	pantoate-binding site; other site
497978001942	HXXH motif; other site
497978001943	glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416
497978001944	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
497978001945	dimerization domain swap beta strand [polypeptide binding]; other site
497978001946	regulatory protein interface [polypeptide binding]; other site
497978001947	active site
497978001948	regulatory phosphorylation site [posttranslational modification]; other site
497978001949	hypothetical protein; Provisional; Region: PRK05255
497978001950	acyl-CoA synthetase; Validated; Region: PRK08162
497978001951	Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles and Arabidopsis; Region: ttLC_FACS_AEE21_like; cd12118
497978001952	acyl-activating enzyme (AAE) consensus motif; other site
497978001953	putative active site [active]
497978001954	AMP binding site [chemical binding]; other site
497978001955	putative CoA binding site [chemical binding]; other site
497978001956	threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413
497978001957	TGS _ThrRS_N:  ThrRS (threonyl-tRNA Synthetase)  is a class II tRNA synthetase that couples threonine to its cognate tRNA.  In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667
497978001958	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
497978001959	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
497978001960	active site
497978001961	dimer interface [polypeptide binding]; other site
497978001962	motif 1; other site
497978001963	motif 2; other site
497978001964	motif 3; other site
497978001965	ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860
497978001966	anticodon binding site; other site
497978001967	GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972
497978001968	GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048
497978001969	C-terminal domain interface [polypeptide binding]; other site
497978001970	GSH binding site (G-site) [chemical binding]; other site
497978001971	dimer interface [polypeptide binding]; other site
497978001972	C-terminal, alpha helical domain of Escherichia coli YfcG Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YfcG_like; cd10291
497978001973	N-terminal domain interface [polypeptide binding]; other site
497978001974	putative dimer interface [polypeptide binding]; other site
497978001975	active site
497978001976	Predicted membrane protein [Function unknown]; Region: COG1238
497978001977	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
497978001978	putative substrate translocation pore; other site
497978001979	H+ Antiporter protein; Region: 2A0121; TIGR00900
497978001980	50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172
497978001981	Ribosomal protein L20; Region: Ribosomal_L20; cd07026
497978001982	23S rRNA binding site [nucleotide binding]; other site
497978001983	L21 binding site [polypeptide binding]; other site
497978001984	L13 binding site [polypeptide binding]; other site
497978001985	Domain of unknown function (DUF1768); Region: DUF1768; pfam08719
497978001986	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
497978001987	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
497978001988	Coenzyme A binding pocket [chemical binding]; other site
497978001989	phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488
497978001990	Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912
497978001991	Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496
497978001992	dimer interface [polypeptide binding]; other site
497978001993	motif 1; other site
497978001994	active site
497978001995	motif 2; other site
497978001996	motif 3; other site
497978001997	phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629
497978001998	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
497978001999	putative tRNA-binding site [nucleotide binding]; other site
497978002000	B3/4 domain; Region: B3_4; pfam03483
497978002001	tRNA synthetase B5 domain; Region: B5; smart00874
497978002002	Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA,  PheRS is an...; Region: PheRS_beta_core; cd00769
497978002003	dimer interface [polypeptide binding]; other site
497978002004	motif 1; other site
497978002005	motif 3; other site
497978002006	motif 2; other site
497978002007	Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147
497978002008	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
497978002009	IHF dimer interface [polypeptide binding]; other site
497978002010	IHF - DNA interface [nucleotide binding]; other site
497978002011	transcription termination factor Rho; Provisional; Region: rho; PRK09376
497978002012	Rho termination factor, N-terminal domain; Region: Rho_N; smart00959
497978002013	Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459
497978002014	RNA binding site [nucleotide binding]; other site
497978002015	Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128
497978002016	multimer interface [polypeptide binding]; other site
497978002017	Walker A motif; other site
497978002018	ATP binding site [chemical binding]; other site
497978002019	Walker B motif; other site
497978002020	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
497978002021	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
497978002022	catalytic residues [active]
497978002023	guanosine pentaphosphate phosphohydrolase; Provisional; Region: PRK11031
497978002024	Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541
497978002025	acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724
497978002026	pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880
497978002027	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232
497978002028	YGGT family; Region: YGGT; pfam02325
497978002029	DNA polymerase I; Provisional; Region: PRK05755
497978002030	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
497978002031	active site
497978002032	metal binding site 1 [ion binding]; metal-binding site
497978002033	putative 5' ssDNA interaction site; other site
497978002034	metal binding site 3; metal-binding site
497978002035	metal binding site 2 [ion binding]; metal-binding site
497978002036	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
497978002037	putative DNA binding site [nucleotide binding]; other site
497978002038	putative metal binding site [ion binding]; other site
497978002039	DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139
497978002040	active site
497978002041	catalytic site [active]
497978002042	substrate binding site [chemical binding]; other site
497978002043	Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637
497978002044	active site
497978002045	DNA binding site [nucleotide binding]
497978002046	catalytic site [active]
497978002047	Predicted membrane protein (DUF2339); Region: DUF2339; pfam10101
497978002048	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
497978002049	Mechanosensitive ion channel; Region: MS_channel; pfam00924
497978002050	Protein of unknown function (DUF432); Region: DUF432; cl01027
497978002051	type II secretion system protein E; Region: type_II_gspE; TIGR02533
497978002052	PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129
497978002053	Walker A motif; other site
497978002054	ATP binding site [chemical binding]; other site
497978002055	Walker B motif; other site
497978002056	peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561
497978002057	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
497978002058	MarR family; Region: MarR; pfam01047
497978002059	Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases); Region: nit; cd07572
497978002060	nitrilase; Region: PLN02798
497978002061	putative active site [active]
497978002062	catalytic triad [active]
497978002063	dimer interface [polypeptide binding]; other site
497978002064	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
497978002065	anti sigma factor interaction site; other site
497978002066	regulatory phosphorylation site [posttranslational modification]; other site
497978002067	Sigma factor PP2C-like phosphatases; Region: PP2C_SIG; smart00331
497978002068	VacJ like lipoprotein; Region: VacJ; cl01073
497978002069	RNA polymerase factor sigma-54; Reviewed; Region: PRK05932
497978002070	Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309
497978002071	Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963
497978002072	Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552
497978002073	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552
497978002074	30S subunit binding site; other site
497978002075	BolA-like protein; Region: BolA; cl00386
497978002076	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
497978002077	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
497978002078	hinge; other site
497978002079	active site
497978002080	ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040
497978002081	ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686
497978002082	Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572
497978002083	histidinol dehydrogenase; Region: hisD; TIGR00069
497978002084	NAD binding site [chemical binding]; other site
497978002085	dimerization interface [polypeptide binding]; other site
497978002086	product binding site; other site
497978002087	substrate binding site [chemical binding]; other site
497978002088	zinc binding site [ion binding]; other site
497978002089	catalytic residues [active]
497978002090	Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079
497978002091	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
497978002092	pyridoxal 5'-phosphate binding site [chemical binding]; other site
497978002093	homodimer interface [polypeptide binding]; other site
497978002094	catalytic residue [active]
497978002095	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
497978002096	Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147
497978002097	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
497978002098	A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39G; cd02423
497978002099	putative active site [active]
497978002100	Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; cl17479
497978002101	NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297
497978002102	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_4; cd04511
497978002103	nudix motif; other site
497978002104	Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426
497978002105	putative active site [active]
497978002106	putative CoA binding site [chemical binding]; other site
497978002107	nudix motif; other site
497978002108	metal binding site [ion binding]; metal-binding site
497978002109	Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663
497978002110	Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645
497978002111	trimer interface [polypeptide binding]; other site
497978002112	putative metal binding site [ion binding]; other site
497978002113	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
497978002114	Glycoprotease family; Region: Peptidase_M22; pfam00814
497978002115	Putative SAM-dependent methyltransferase; Region: SAM_MT; cl17517
497978002116	Peptidase C13 family; Region: Peptidase_C13; pfam01650
497978002117	S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821
497978002118	S-formylglutathione hydrolase; Region: PLN02442
497978002119	Uncharacterized protein conserved in bacteria (DUF2218); Region: DUF2218; pfam09981
497978002120	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
497978002121	ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163
497978002122	substrate binding site [chemical binding]; other site
497978002123	hexamer interface [polypeptide binding]; other site
497978002124	metal binding site [ion binding]; metal-binding site
497978002125	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
497978002126	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
497978002127	active site
497978002128	motif I; other site
497978002129	motif II; other site
497978002130	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
497978002131	copper-resistance protein, CopA family; Region: copper_res_A; TIGR01480
497978002132	Multicopper oxidase; Region: Cu-oxidase_3; pfam07732
497978002133	Multicopper oxidase; Region: Cu-oxidase; pfam00394
497978002134	Multicopper oxidase; Region: Cu-oxidase_2; pfam07731
497978002135	Copper resistance protein B precursor (CopB); Region: CopB; pfam05275
497978002136	Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230
497978002137	Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076
497978002138	6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870
497978002139	methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901
497978002140	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
497978002141	DNA binding site [nucleotide binding]
497978002142	active site
497978002143	Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152
497978002144	heterotetramer interface [polypeptide binding]; other site
497978002145	active site pocket [active]
497978002146	cleavage site
497978002147	quinolinate synthetase; Provisional; Region: PRK09375
497978002148	Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816
497978002149	Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320
497978002150	active site
497978002151	purine riboside binding site [chemical binding]; other site
497978002152	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
497978002153	Alcohol dehydrogenases of the MDR family; Region: Zn_ADH8; cd08262
497978002154	putative NAD(P) binding site [chemical binding]; other site
497978002155	catalytic Zn binding site [ion binding]; other site
497978002156	Glutaryl-CoA dehydrogenase; Region: GCD; cd01151
497978002157	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
497978002158	FAD binding site [chemical binding]; other site
497978002159	substrate binding pocket [chemical binding]; other site
497978002160	catalytic base [active]
497978002161	benzoate transport; Region: 2A0115; TIGR00895
497978002162	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
497978002163	putative substrate translocation pore; other site
497978002164	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
497978002165	nitrobindin heme-binding domain; Region: nitrobindin; cl10502
497978002166	CoA-transferase family III; Region: CoA_transf_3; pfam02515
497978002167	tricarballylate utilization protein B; Provisional; Region: PRK15033
497978002168	tricarballylate dehydrogenase; Validated; Region: PRK08274
497978002169	Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730
497978002170	nitrogen assimilation transcriptional regulator; Provisional; Region: PRK11233
497978002171	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
497978002172	The C-teminal substrate binding domain of LysR-like nitrogen assimilation control (NAC) protein, contains the type 2 periplasmic binding fold; Region: PBP2_Nac; cd08433
497978002173	putative dimerization interface [polypeptide binding]; other site
497978002174	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
497978002175	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
497978002176	citrate-proton symporter; Provisional; Region: PRK15075
497978002177	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
497978002178	putative substrate translocation pore; other site
497978002179	Transcriptional regulator [Transcription]; Region: LysR; COG0583
497978002180	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
497978002181	The C-teminal substrate binding domain of LysR-like nitrogen assimilation control (NAC) protein, contains the type 2 periplasmic binding fold; Region: PBP2_Nac; cd08433
497978002182	putative dimerization interface [polypeptide binding]; other site
497978002183	Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; cl17479
497978002184	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
497978002185	M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like6; cd05664
497978002186	metal binding site [ion binding]; metal-binding site
497978002187	putative dimer interface [polypeptide binding]; other site
497978002188	Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625
497978002189	SurA N-terminal domain; Region: SurA_N; pfam09312
497978002190	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
497978002191	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
497978002192	Fatty acid desaturase; Region: FA_desaturase; pfam00487
497978002193	LysE type translocator; Region: LysE; cl00565
497978002194	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
497978002195	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
497978002196	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
497978002197	dimerization interface [polypeptide binding]; other site
497978002198	Domain of unknown function (DUF1852); Region: DUF1852; pfam08908
497978002199	methionine synthase; Provisional; Region: PRK01207
497978002200	CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311
497978002201	substrate binding site [chemical binding]; other site
497978002202	THF binding site; other site
497978002203	zinc-binding site [ion binding]; other site
497978002204	Flavin Reductases; Region: FlaRed; cl00801
497978002205	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
497978002206	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
497978002207	Restriction endonuclease; Region: Mrr_cat; pfam04471
497978002208	AAA ATPase domain; Region: AAA_16; pfam13191
497978002209	AAA domain; Region: AAA_22; pfam13401
497978002210	Transcriptional regulator [Transcription]; Region: LysR; COG0583
497978002211	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
497978002212	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
497978002213	dimerization interface [polypeptide binding]; other site
497978002214	hypothetical protein; Provisional; Region: PRK10281
497978002215	hypothetical protein; Provisional; Region: PRK08296
497978002216	membrane-bound PQQ-dependent dehydrogenase, glucose/quinate/shikimate family; Region: PQQ_membr_DH; TIGR03074
497978002217	Membrane-bound PQQ-dependent glucose dehydrogenase; Region: PQQ_mGDH; cd10280
497978002218	Trp docking motif [polypeptide binding]; other site
497978002219	putative active site [active]
497978002220	TniQ; Region: TniQ; pfam06527
497978002221	Helix-turn-helix domain; Region: HTH_17; pfam12728
497978002222	Bacterial TniB protein; Region: TniB; pfam05621
497978002223	AAA domain; Region: AAA_22; pfam13401
497978002224	Integrase core domain; Region: rve; pfam00665
497978002225	TnsA endonuclease N terminal; Region: Tn7_Tnp_TnsA_N; pfam08722
497978002226	phage-associated protein, BcepMu gp16 family; Region: BcepMu_gp16; TIGR04111
497978002227	Protein of unknown function (DUF4007); Region: DUF4007; pfam13182
497978002228	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
497978002229	Active Sites [active]
497978002230	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
497978002231	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c_3; pfam13589
497978002232	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
497978002233	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
497978002234	ATP binding site [chemical binding]; other site
497978002235	Mg2+ binding site [ion binding]; other site
497978002236	G-X-G motif; other site
497978002237	Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049
497978002238	dimer interface [polypeptide binding]; other site
497978002239	putative radical transfer pathway; other site
497978002240	diiron center [ion binding]; other site
497978002241	tyrosyl radical; other site
497978002242	ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07207
497978002243	ATP cone domain; Region: ATP-cone; pfam03477
497978002244	Class I ribonucleotide reductase; Region: RNR_I; cd01679
497978002245	active site
497978002246	dimer interface [polypeptide binding]; other site
497978002247	catalytic residues [active]
497978002248	effector binding site; other site
497978002249	R2 peptide binding site; other site
497978002250	DNA-binding transcriptional regulator RstA; Provisional; Region: PRK10701
497978002251	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
497978002252	active site
497978002253	phosphorylation site [posttranslational modification]
497978002254	intermolecular recognition site; other site
497978002255	dimerization interface [polypeptide binding]; other site
497978002256	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
497978002257	DNA binding site [nucleotide binding]
497978002258	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
497978002259	dimerization interface [polypeptide binding]; other site
497978002260	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
497978002261	dimer interface [polypeptide binding]; other site
497978002262	phosphorylation site [posttranslational modification]
497978002263	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
497978002264	ATP binding site [chemical binding]; other site
497978002265	Mg2+ binding site [ion binding]; other site
497978002266	G-X-G motif; other site
497978002267	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
497978002268	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
497978002269	metal binding site [ion binding]; metal-binding site
497978002270	active site
497978002271	I-site; other site
497978002272	NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602
497978002273	NADH dehydrogenase subunit B; Validated; Region: PRK06411
497978002274	bifunctional NADH:ubiquinone oxidoreductase subunit C/D; Provisional; Region: PRK11742
497978002275	NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961
497978002276	NADH dehydrogenase subunit D; Validated; Region: PRK06075
497978002277	NADH dehydrogenase subunit E; Validated; Region: PRK07539
497978002278	TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064
497978002279	putative dimer interface [polypeptide binding]; other site
497978002280	[2Fe-2S] cluster binding site [ion binding]; other site
497978002281	NADH dehydrogenase I subunit F; Provisional; Region: PRK11278
497978002282	SLBB domain; Region: SLBB; pfam10531
497978002283	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928
497978002284	NADH dehydrogenase subunit G; Validated; Region: PRK08166
497978002285	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
497978002286	catalytic loop [active]
497978002287	iron binding site [ion binding]; other site
497978002288	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588
497978002289	MopB_NDH-1_NuoG2-N7: The second domain of the NuoG subunit (with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex in the respiratory...; Region: MopB_NDH-1_NuoG2-N7; cd02771
497978002290	[4Fe-4S] binding site [ion binding]; other site
497978002291	MopB_CT_NDH-1_NuoG2-N7: C-terminal region of the NuoG-like subunit (of the variant with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex...; Region: MopB_CT_NDH-1_NuoG2-N7; cd02788
497978002292	NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076
497978002293	Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650
497978002294	NADH-quinone oxidoreductase, chain I; Region: NuoI; TIGR01971
497978002295	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
497978002296	NADH:ubiquinone oxidoreductase subunit 6 (chain J) [Energy production and conversion]; Region: NuoJ; COG0839
497978002297	NADH dehydrogenase subunit J; Provisional; Region: PRK06433
497978002298	NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715
497978002299	NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590
497978002300	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662
497978002301	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
497978002302	NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846
497978002303	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
497978002304	NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777
497978002305	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
497978002306	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
497978002307	active site
497978002308	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
497978002309	DNA-binding site [nucleotide binding]; DNA binding site
497978002310	RNA-binding motif; other site
497978002311	putative DNA-binding transcriptional regulator; Provisional; Region: PRK10837
497978002312	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
497978002313	C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420
497978002314	putative dimerization interface [polypeptide binding]; other site
497978002315	ferredoxin-NADP reductase; Provisional; Region: PRK10926
497978002316	Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195
497978002317	FAD binding pocket [chemical binding]; other site
497978002318	FAD binding motif [chemical binding]; other site
497978002319	phosphate binding motif [ion binding]; other site
497978002320	beta-alpha-beta structure motif; other site
497978002321	NAD binding pocket [chemical binding]; other site
497978002322	Conserved TM helix; Region: TM_helix; pfam05552
497978002323	Conserved TM helix; Region: TM_helix; pfam05552
497978002324	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
497978002325	Conserved TM helix; Region: TM_helix; pfam05552
497978002326	Conserved TM helix; Region: TM_helix; pfam05552
497978002327	HI0933-like protein; Region: HI0933_like; pfam03486
497978002328	Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342
497978002329	Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291
497978002330	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
497978002331	catalytic residue [active]
497978002332	efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998
497978002333	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
497978002334	HlyD family secretion protein; Region: HlyD_3; pfam13437
497978002335	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
497978002336	Major Facilitator Superfamily; Region: MFS_1; pfam07690
497978002337	putative substrate translocation pore; other site
497978002338	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
497978002339	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
497978002340	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
497978002341	methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133
497978002342	catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814
497978002343	active site
497978002344	HIGH motif; other site
497978002345	KMSKS motif; other site
497978002346	Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957
497978002347	tRNA binding surface [nucleotide binding]; other site
497978002348	anticodon binding site; other site
497978002349	tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins.  This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties.  MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800
497978002350	dimer interface [polypeptide binding]; other site
497978002351	putative tRNA-binding site [nucleotide binding]; other site
497978002352	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489
497978002353	MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037
497978002354	Phosphorylase superfamily; Region: PNP_UDP_1; pfam01048
497978002355	Uncharacterized protein conserved in bacteria (DUF2062); Region: DUF2062; pfam09835
497978002356	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
497978002357	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
497978002358	trimer interface [polypeptide binding]; other site
497978002359	active site
497978002360	tRNA-dihydrouridine synthase C; Provisional; Region: PRK10550
497978002361	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
497978002362	FMN binding site [chemical binding]; other site
497978002363	active site
497978002364	catalytic residues [active]
497978002365	substrate binding site [chemical binding]; other site
497978002366	Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504
497978002367	signal recognition particle protein; Provisional; Region: PRK10867
497978002368	SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963
497978002369	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
497978002370	GTP binding site [chemical binding]; other site
497978002371	Signal peptide binding domain; Region: SRP_SPB; pfam02978
497978002372	pantothenate kinase; Reviewed; Region: PRK13322
497978002373	Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340
497978002374	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057
497978002375	Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237
497978002376	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
497978002377	Transcriptional regulators [Transcription]; Region: GntR; COG1802
497978002378	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
497978002379	DNA-binding site [nucleotide binding]; DNA binding site
497978002380	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
497978002381	AAA domain; Region: AAA_23; pfam13476
497978002382	Walker A/P-loop; other site
497978002383	ATP binding site [chemical binding]; other site
497978002384	Q-loop/lid; other site
497978002385	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
497978002386	ABC transporter signature motif; other site
497978002387	Walker B; other site
497978002388	D-loop; other site
497978002389	H-loop/switch region; other site
497978002390	ZipA, C-terminal FtsZ-binding domain; Region: ZipA_C; pfam04354
497978002391	FtsZ protein binding site [polypeptide binding]; other site
497978002392	NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956
497978002393	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114
497978002394	nucleotide binding pocket [chemical binding]; other site
497978002395	K-X-D-G motif; other site
497978002396	catalytic site [active]
497978002397	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
497978002398	NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119
497978002399	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027
497978002400	Dimer interface [polypeptide binding]; other site
497978002401	BRCT sequence motif; other site
497978002402	Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193
497978002403	Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907
497978002404	heme binding site [chemical binding]; other site
497978002405	ferroxidase pore; other site
497978002406	ferroxidase diiron center [ion binding]; other site
497978002407	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
497978002408	Major Facilitator Superfamily; Region: MFS_1; pfam07690
497978002409	putative substrate translocation pore; other site
497978002410	Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788
497978002411	alpha,alpha-trehalose-phosphate synthase [UDP-forming]; Region: trehalose_OtsA; TIGR02400
497978002412	active site
497978002413	homotetramer interface [polypeptide binding]; other site
497978002414	Trehalose-6-phosphatase [Carbohydrate transport and metabolism]; Region: OtsB; COG1877
497978002415	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
497978002416	active site
497978002417	motif I; other site
497978002418	motif II; other site
497978002419	carboxylesterase BioH; Provisional; Region: PRK10349
497978002420	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
497978002421	adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK06173
497978002422	inhibitor-cofactor binding pocket; inhibition site
497978002423	pyridoxal 5'-phosphate binding site [chemical binding]; other site
497978002424	catalytic residue [active]
497978002425	8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958
497978002426	pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825
497978002427	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
497978002428	catalytic residue [active]
497978002429	biotin biosynthesis protein BioC; Region: BioC; TIGR02072
497978002430	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
497978002431	S-adenosylmethionine binding site [chemical binding]; other site
497978002432	dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090
497978002433	AAA domain; Region: AAA_26; pfam13500
497978002434	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
497978002435	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
497978002436	RNA binding surface [nucleotide binding]; other site
497978002437	Pseudouridine synthase, Escherichia coli RluB like; Region: PseudoU_synth_RluB; cd02556
497978002438	probable active site [active]
497978002439	Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079
497978002440	ScpA/B protein; Region: ScpA_ScpB; cl00598
497978002441	Telomere recombination; Region: Sua5_yciO_yrdC; cl00305
497978002442	Protein of unknown function, DUF462; Region: DUF462; pfam04315
497978002443	Uncharacterized ACR, COG1399; Region: DUF177; pfam02620
497978002444	50S ribosomal protein L32; Validated; Region: rpmF; PRK01110
497978002445	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
497978002446	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
497978002447	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
497978002448	3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830
497978002449	NAD(P) binding site [chemical binding]; other site
497978002450	homotetramer interface [polypeptide binding]; other site
497978002451	homodimer interface [polypeptide binding]; other site
497978002452	active site
497978002453	acyl carrier protein; Provisional; Region: acpP; PRK00982
497978002454	LysM domain/BON superfamily protein; Provisional; Region: PRK11198
497978002455	BON domain; Region: BON; pfam04972
497978002456	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
497978002457	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
497978002458	dimer interface [polypeptide binding]; other site
497978002459	substrate binding site [chemical binding]; other site
497978002460	ATP binding site [chemical binding]; other site
497978002461	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
497978002462	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
497978002463	motif II; other site
497978002464	3,4-dihydroxy-2-butanone 4-phosphate synthase; Provisional; Region: ribB; PRK03353
497978002465	3,4-dihydroxy-2-butanone 4-phosphate synthase [Coenzyme metabolism]; Region: RibB; COG0108
497978002466	Domain of unknown function (DUF4401); Region: DUF4401; pfam14351
497978002467	GDYXXLXY protein; Region: GDYXXLXY; pfam14345
497978002468	Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent  decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919
497978002469	tetramerization interface [polypeptide binding]; other site
497978002470	active site
497978002471	Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
497978002472	putative active site [active]
497978002473	catalytic residue [active]
497978002474	Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495
497978002475	5S rRNA interface [nucleotide binding]; other site
497978002476	CTC domain interface [polypeptide binding]; other site
497978002477	L16 interface [polypeptide binding]; other site
497978002478	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259
497978002479	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
497978002480	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
497978002481	active site
497978002482	outer membrane lipoprotein LolB; Provisional; Region: lolB; PRK00022
497978002483	Outer membrane lipoprotein LolB; Region: LolB; pfam03550
497978002484	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
497978002485	binding surface
497978002486	TPR motif; other site
497978002487	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
497978002488	binding surface
497978002489	TPR motif; other site
497978002490	glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045
497978002491	NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213
497978002492	tRNA; other site
497978002493	putative tRNA binding site [nucleotide binding]; other site
497978002494	putative NADP binding site [chemical binding]; other site
497978002495	Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745
497978002496	DNA primase; Validated; Region: dnaG; PRK05667
497978002497	CHC2 zinc finger; Region: zf-CHC2; pfam01807
497978002498	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
497978002499	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
497978002500	active site
497978002501	metal binding site [ion binding]; metal-binding site
497978002502	interdomain interaction site; other site
497978002503	DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410
497978002504	Outer membrane lipoprotein; Region: YfiO; pfam13525
497978002505	23S rRNA pseudouridine synthase D; Provisional; Region: rluD; PRK11180
497978002506	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
497978002507	RNA binding surface [nucleotide binding]; other site
497978002508	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
497978002509	active site
497978002510	Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578
497978002511	Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496
497978002512	Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655
497978002513	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
497978002514	Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294
497978002515	SmpB-tmRNA interface; other site
497978002516	phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168
497978002517	Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163
497978002518	active site
497978002519	(T/H)XGH motif; other site
497978002520	4Fe-4S dicluster domain; Region: Fer4_9; pfam13187
497978002521	Phosphate-selective porin O and P; Region: Porin_O_P; pfam07396
497978002522	transcriptional activator TtdR; Provisional; Region: PRK09801
497978002523	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
497978002524	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_9; cd08479
497978002525	putative effector binding pocket; other site
497978002526	putative dimerization interface [polypeptide binding]; other site
497978002527	Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473
497978002528	tartrate dehydrogenase; Region: TTC; TIGR02089
497978002529	putative transporter; Provisional; Region: PRK09950
497978002530	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
497978002531	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
497978002532	substrate binding pocket [chemical binding]; other site
497978002533	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
497978002534	Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469
497978002535	[2Fe-2S] cluster binding site [ion binding]; other site
497978002536	C-terminal catalytic domain of the oxygenase alpha subunit of an uncharacterized subgroup of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C_2; cd08886
497978002537	putative alpha subunit interface [polypeptide binding]; other site
497978002538	putative active site [active]
497978002539	putative substrate binding site [chemical binding]; other site
497978002540	Fe binding site [ion binding]; other site
497978002541	succinic semialdehyde dehydrogenase; Region: PLN02278
497978002542	Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103
497978002543	tetramerization interface [polypeptide binding]; other site
497978002544	NAD(P) binding site [chemical binding]; other site
497978002545	catalytic residues [active]
497978002546	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
497978002547	Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal  ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185
497978002548	FMN-binding pocket [chemical binding]; other site
497978002549	flavin binding motif; other site
497978002550	phosphate binding motif [ion binding]; other site
497978002551	beta-alpha-beta structure motif; other site
497978002552	NAD binding pocket [chemical binding]; other site
497978002553	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
497978002554	catalytic loop [active]
497978002555	iron binding site [ion binding]; other site
497978002556	NAD synthetase; Provisional; Region: PRK13981
497978002557	Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570
497978002558	multimer interface [polypeptide binding]; other site
497978002559	active site
497978002560	catalytic triad [active]
497978002561	protein interface 1 [polypeptide binding]; other site
497978002562	NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553
497978002563	homodimer interface [polypeptide binding]; other site
497978002564	NAD binding pocket [chemical binding]; other site
497978002565	ATP binding pocket [chemical binding]; other site
497978002566	Mg binding site [ion binding]; other site
497978002567	active-site loop [active]
497978002568	Pirin; Region: Pirin; pfam02678
497978002569	Pirin-related protein [General function prediction only]; Region: COG1741
497978002570	Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726
497978002571	Uncharacterized protein family (UPF0093); Region: UPF0093; pfam03653
497978002572	3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK07967
497978002573	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
497978002574	dimer interface [polypeptide binding]; other site
497978002575	active site
497978002576	EcsC protein family; Region: EcsC; pfam12787
497978002577	S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368
497978002578	S17 interaction site [polypeptide binding]; other site
497978002579	S8 interaction site; other site
497978002580	16S rRNA interaction site [nucleotide binding]; other site
497978002581	streptomycin interaction site [chemical binding]; other site
497978002582	23S rRNA interaction site [nucleotide binding]; other site
497978002583	aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site
497978002584	30S ribosomal protein S7; Validated; Region: PRK05302
497978002585	elongation factor G; Reviewed; Region: PRK00007
497978002586	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
497978002587	G1 box; other site
497978002588	putative GEF interaction site [polypeptide binding]; other site
497978002589	GTP/Mg2+ binding site [chemical binding]; other site
497978002590	Switch I region; other site
497978002591	G2 box; other site
497978002592	G3 box; other site
497978002593	Switch II region; other site
497978002594	G4 box; other site
497978002595	G5 box; other site
497978002596	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
497978002597	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
497978002598	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
497978002599	elongation factor Tu; Reviewed; Region: PRK00049
497978002600	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
497978002601	G1 box; other site
497978002602	GEF interaction site [polypeptide binding]; other site
497978002603	GTP/Mg2+ binding site [chemical binding]; other site
497978002604	Switch I region; other site
497978002605	G2 box; other site
497978002606	G3 box; other site
497978002607	Switch II region; other site
497978002608	G4 box; other site
497978002609	G5 box; other site
497978002610	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
497978002611	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
497978002612	Antibiotic Binding Site [chemical binding]; other site
497978002613	Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687
497978002614	Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118
497978002615	Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687
497978002616	Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118
497978002617	ribosomal-protein-alanine N-acetyltransferase; Provisional; Region: rimI; PRK09491
497978002618	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
497978002619	Coenzyme A binding pocket [chemical binding]; other site
497978002620	arginyl-tRNA-protein transferase; Provisional; Region: PRK01305
497978002621	Arginine-tRNA-protein transferase, N terminus; Region: ATE_N; pfam04376
497978002622	Arginine-tRNA-protein transferase, C terminus; Region: ATE_C; pfam04377
497978002623	leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301
497978002624	thioredoxin reductase; Provisional; Region: PRK10262
497978002625	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
497978002626	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
497978002627	Domain of unknown function (DUF4117); Region: DUF4117; pfam13491
497978002628	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
497978002629	This domain directs oriented DNA translocation and forms a winged helix structure; Region: Ftsk_gamma; smart00843
497978002630	threonine efflux system; Provisional; Region: PRK10229
497978002631	Domain of unknown function (DUF4234); Region: DUF4234; pfam14018
497978002632	Septum formation topological specificity factor MinE; Region: MinE; pfam03776
497978002633	Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894
497978002634	Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036
497978002635	Switch I; other site
497978002636	Switch II; other site
497978002637	Septum formation inhibitor [Cell division and chromosome partitioning]; Region: MinC; COG0850
497978002638	Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775
497978002639	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
497978002640	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; Region: LPLAT_LCLAT1-like; cd07990
497978002641	putative acyl-acceptor binding pocket; other site
497978002642	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
497978002643	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
497978002644	ligand binding site [chemical binding]; other site
497978002645	ATP-dependent DNA helicase Rep; Region: rep; TIGR01074
497978002646	Part of AAA domain; Region: AAA_19; pfam13245
497978002647	Family description; Region: UvrD_C_2; pfam13538
497978002648	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
497978002649	trimer interface [polypeptide binding]; other site
497978002650	active site
497978002651	Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109
497978002652	The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089
497978002653	active site
497978002654	substrate binding site [chemical binding]; other site
497978002655	metal binding site [ion binding]; metal-binding site
497978002656	AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250
497978002657	feedback inhibition sensing region; other site
497978002658	homohexameric interface [polypeptide binding]; other site
497978002659	nucleotide binding site [chemical binding]; other site
497978002660	N-acetyl-L-glutamate binding site [chemical binding]; other site
497978002661	Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; pfam13444
497978002662	Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121
497978002663	Glutamine amidotransferases class-II (Gn-AT)_YafJ-type.  YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea.  YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908
497978002664	putative active site [active]
497978002665	putative dimer interface [polypeptide binding]; other site
497978002666	Hemerythrin; Region: Hemerythrin; cd12107
497978002667	Fe binding site [ion binding]; other site
497978002668	Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456
497978002669	Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456
497978002670	hypothetical protein; Validated; Region: PRK01777
497978002671	outer membrane biogenesis protein BamE; Provisional; Region: PRK11548
497978002672	SmpA / OmlA family; Region: SmpA_OmlA; pfam04355
497978002673	ferric uptake regulator; Provisional; Region: fur; PRK09462
497978002674	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
497978002675	metal binding site 2 [ion binding]; metal-binding site
497978002676	putative DNA binding helix; other site
497978002677	metal binding site 1 [ion binding]; metal-binding site
497978002678	dimer interface [polypeptide binding]; other site
497978002679	structural Zn2+ binding site [ion binding]; other site
497978002680	Tfp pilus assembly protein, ATPase PilU [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilU; COG5008
497978002681	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
497978002682	Walker A motif; other site
497978002683	ATP binding site [chemical binding]; other site
497978002684	Walker B motif; other site
497978002685	Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805
497978002686	Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131
497978002687	Walker A motif; other site
497978002688	ATP binding site [chemical binding]; other site
497978002689	Walker B motif; other site
497978002690	Pyridoxal 5-phosphate (PLP)-binding TIM barrel domain of Type III PLP-Dependent Enzymes, Yggs-like proteins; Region: PLPDE_III_Yggs_like; cd06824
497978002691	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
497978002692	catalytic residue [active]
497978002693	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
497978002694	Walker A/P-loop; other site
497978002695	ATP binding site [chemical binding]; other site
497978002696	Q-loop/lid; other site
497978002697	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
497978002698	ABC transporter signature motif; other site
497978002699	Walker B; other site
497978002700	D-loop; other site
497978002701	H-loop/switch region; other site
497978002702	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
497978002703	Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840
497978002704	active site
497978002705	metal binding site [ion binding]; metal-binding site
497978002706	DNA binding site [nucleotide binding]
497978002707	Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320
497978002708	Organic hydroperoxide reductase [Secondary metabolites biosynthesis, transport and catabolism]; Region: osmC; COG1764
497978002709	N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247
497978002710	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
497978002711	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
497978002712	Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090
497978002713	NAD(P) binding site [chemical binding]; other site
497978002714	active site
497978002715	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
497978002716	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
497978002717	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
497978002718	Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823
497978002719	dimer interface [polypeptide binding]; other site
497978002720	allosteric magnesium binding site [ion binding]; other site
497978002721	active site
497978002722	aspartate-rich active site metal binding site; other site
497978002723	Schiff base residues; other site
497978002724	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
497978002725	CoenzymeA binding site [chemical binding]; other site
497978002726	subunit interaction site [polypeptide binding]; other site
497978002727	PHB binding site; other site
497978002728	efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998
497978002729	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
497978002730	HlyD family secretion protein; Region: HlyD_3; pfam13437
497978002731	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
497978002732	Major Facilitator Superfamily; Region: MFS_1; pfam07690
497978002733	putative substrate translocation pore; other site
497978002734	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
497978002735	Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405
497978002736	Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019
497978002737	integrase; Provisional; Region: PRK09692
497978002738	Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements.  They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801
497978002739	active site
497978002740	Int/Topo IB signature motif; other site
497978002741	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
497978002742	putative catalytic site [active]
497978002743	putative phosphate binding site [ion binding]; other site
497978002744	putative metal binding site [ion binding]; other site
497978002745	FRG domain; Region: FRG; cl07460
497978002746	FRG domain; Region: FRG; cl07460
497978002747	Ead/Ea22-like protein; Region: Ead_Ea22; pfam13935
497978002748	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
497978002749	exodeoxyribonuclease X; Provisional; Region: PRK07983
497978002750	active site
497978002751	catalytic site [active]
497978002752	substrate binding site [chemical binding]; other site
497978002753	Uncharacterized conserved protein (DUF2303); Region: DUF2303; cl02338
497978002754	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
497978002755	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
497978002756	non-specific DNA binding site [nucleotide binding]; other site
497978002757	salt bridge; other site
497978002758	sequence-specific DNA binding site [nucleotide binding]; other site
497978002759	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
497978002760	Catalytic site [active]
497978002761	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
497978002762	sequence-specific DNA binding site [nucleotide binding]; other site
497978002763	salt bridge; other site
497978002764	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
497978002765	Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270
497978002766	cofactor binding site; other site
497978002767	DNA binding site [nucleotide binding]
497978002768	substrate interaction site [chemical binding]; other site
497978002769	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
497978002770	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
497978002771	Walker A motif; other site
497978002772	ATP binding site [chemical binding]; other site
497978002773	Walker B motif; other site
497978002774	arginine finger; other site
497978002775	Endodeoxyribonuclease RusA; Region: RusA; pfam05866
497978002776	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
497978002777	non-specific DNA binding site [nucleotide binding]; other site
497978002778	salt bridge; other site
497978002779	sequence-specific DNA binding site [nucleotide binding]; other site
497978002780	Glycine zipper 2TM domain; Region: Rick_17kDa_Anti; cl10470
497978002781	Protein of unknown function (DUF1311); Region: DUF1311; pfam07007
497978002782	Abi-like protein; Region: Abi_2; pfam07751
497978002783	putative pectinesterase; Region: PLN02432; cl01911
497978002784	Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755
497978002785	Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cl17442
497978002786	protein-splicing catalytic site; other site
497978002787	thioester formation/cholesterol transfer; other site
497978002788	P22_AR N-terminal domain; Region: P22_AR_N; pfam10547
497978002789	P22_AR N-terminal domain; Region: P22_AR_N; pfam10547
497978002790	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153
497978002791	Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026
497978002792	Uncharacterized archaeal coiled-coil protein [Function unknown]; Region: COG1340
497978002793	Carbohydrate binding domain; Region: CBM_4_9; pfam02018
497978002794	Domain of unknown function (DUF1983); Region: DUF1983; pfam09327
497978002795	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
497978002796	putative Mg++ binding site [ion binding]; other site
497978002797	Helicase_C-like; Region: Helicase_C_4; pfam13871
497978002798	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
497978002799	S-adenosylmethionine binding site [chemical binding]; other site
497978002800	TIGR02594 family protein; Region: TIGR02594
497978002801	extracellular lipase, Pla-1/cef family; Region: lipase_Pla1_cef; TIGR03502
497978002802	PAAR motif; Region: PAAR_motif; pfam05488
497978002803	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
497978002804	glutamyl-tRNA reductase; Provisional; Region: PRK13940
497978002805	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
497978002806	AAA domain; Region: AAA_21; pfam13304
497978002807	Walker A/P-loop; other site
497978002808	ATP binding site [chemical binding]; other site
497978002809	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
497978002810	Walker B; other site
497978002811	D-loop; other site
497978002812	H-loop/switch region; other site
497978002813	Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dam; COG0338
497978002814	outer membrane porin, OprD family; Region: OprD; pfam03573
497978002815	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
497978002816	benzoate transport; Region: 2A0115; TIGR00895
497978002817	putative substrate translocation pore; other site
497978002818	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
497978002819	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
497978002820	Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408
497978002821	inhibitor site; inhibition site
497978002822	active site
497978002823	dimer interface [polypeptide binding]; other site
497978002824	catalytic residue [active]
497978002825	Transcriptional regulator [Transcription]; Region: LysR; COG0583
497978002826	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
497978002827	The C-teminal substrate binding domain of LysR-like nitrogen assimilation control (NAC) protein, contains the type 2 periplasmic binding fold; Region: PBP2_Nac; cd08433
497978002828	putative dimerization interface [polypeptide binding]; other site
497978002829	RNA polymerase sigma factor; Reviewed; Region: PRK12523
497978002830	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
497978002831	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
497978002832	DNA binding residues [nucleotide binding]
497978002833	Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712
497978002834	FecR protein; Region: FecR; pfam04773
497978002835	Secretin and TonB N terminus short domain; Region: STN; pfam07660
497978002836	TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786
497978002837	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
497978002838	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
497978002839	TPR repeat; Region: TPR_11; pfam13414
497978002840	Protein of unknown function (DUF560); Region: DUF560; pfam04575
497978002841	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
497978002842	Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cd00232
497978002843	heme binding pocket [chemical binding]; other site
497978002844	heme ligand [chemical binding]; other site
497978002845	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2832
497978002846	Protein of unknown function (DUF1275); Region: DUF1275; pfam06912
497978002847	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
497978002848	PGAP1-like protein; Region: PGAP1; pfam07819
497978002849	arginine-ornithine antiporter; Region: arg_ornith_anti; TIGR03810
497978002850	Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574
497978002851	Homocysteine/selenocysteine methylase (S-methylmethionine-dependent) [Amino acid transport and metabolism]; Region: MHT1; COG2040
497978002852	malate:quinone oxidoreductase; Validated; Region: PRK05257
497978002853	malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320
497978002854	choline dehydrogenase; Validated; Region: PRK02106
497978002855	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
497978002856	betaine aldehyde dehydrogenase; Provisional; Region: PRK13252
497978002857	NAD+-dependent 4-trimethylaminobutyraldehyde dehydrogenase, ALDH family 9A1; Region: ALDH_F9_TMBADH; cd07090
497978002858	tetrameric interface [polypeptide binding]; other site
497978002859	NAD binding site [chemical binding]; other site
497978002860	catalytic residues [active]
497978002861	transcriptional regulator BetI; Validated; Region: PRK00767
497978002862	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
497978002863	Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977
497978002864	BCCT family transporter; Region: BCCT; pfam02028
497978002865	choline transport protein BetT; Provisional; Region: PRK09928
497978002866	Multiple antibiotic transporter [Intracellular trafficking and secretion]; Region: MarC; COG2095
497978002867	Brown fat-inducible thioesterase (BFIT).  Brain acyl-CoA hydrolase (BACH).  These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442
497978002868	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
497978002869	CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492
497978002870	C4-dicarboxylate transporter DctA; Reviewed; Region: PRK13027
497978002871	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
497978002872	YaeQ protein; Region: YaeQ; pfam07152
497978002873	FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545
497978002874	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
497978002875	poly-beta-1,6-N-acetyl-D-glucosamine N-deacetylase PgaB; Region: deacetyl_PgaB; TIGR03938
497978002876	N-terminal putative catalytic polysaccharide deacetylase domain of bacterial poly-beta-1,6-N-acetyl-D-glucosamine N-deacetylase PgaB, and similar proteins; Region: CE4_PgaB_5s; cd10964
497978002877	putative active site [active]
497978002878	putative metal binding site [ion binding]; other site
497978002879	N-glycosyltransferase; Provisional; Region: PRK11204
497978002880	CESA_like is  the cellulose synthase superfamily; Region: CESA_like; cd06423
497978002881	DXD motif; other site
497978002882	PgaD-like protein; Region: PgaD; pfam13994
497978002883	enoyl-CoA hydratase; Provisional; Region: PRK06563
497978002884	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
497978002885	substrate binding site [chemical binding]; other site
497978002886	oxyanion hole (OAH) forming residues; other site
497978002887	trimer interface [polypeptide binding]; other site
497978002888	Nicotinamide mononucleotide transporter; Region: NMN_transporter; pfam04973
497978002889	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
497978002890	Transcriptional regulator [Transcription]; Region: IclR; COG1414
497978002891	Bacterial transcriptional regulator; Region: IclR; pfam01614
497978002892	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938
497978002893	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
497978002894	Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469
497978002895	[2Fe-2S] cluster binding site [ion binding]; other site
497978002896	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
497978002897	hydrophobic ligand binding site; other site
497978002898	short chain dehydrogenase; Provisional; Region: PRK12939
497978002899	classical (c) SDRs; Region: SDR_c; cd05233
497978002900	NAD(P) binding site [chemical binding]; other site
497978002901	active site
497978002902	C-terminal domain of Burkholderia sp. NF100 MhqB and similar proteins; MhqB is a type I extradiol dioxygenase involved in the catabolism of methylhydroquinone, an intermediate in the degradation of fenitrothion; Region: MhqB_like_C; cd08360
497978002903	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
497978002904	putative active site [active]
497978002905	putative metal binding site [ion binding]; other site
497978002906	phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754
497978002907	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
497978002908	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
497978002909	D-galactonate transporter; Region: 2A0114; TIGR00893
497978002910	putative substrate translocation pore; other site
497978002911	Cupin domain; Region: Cupin_2; pfam07883
497978002912	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
497978002913	Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303
497978002914	short chain dehydrogenase; Provisional; Region: PRK07062
497978002915	putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344
497978002916	putative NAD(P) binding site [chemical binding]; other site
497978002917	putative active site [active]
497978002918	L-aspartate dehydrogenase; Provisional; Region: PRK13303
497978002919	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
497978002920	Domain of unknown function DUF108; Region: DUF108; pfam01958
497978002921	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
497978002922	Uncharacterized Candidatus pelagibacter aldehyde dehydrogenase, DhaS-like; Region: ALDH_DhaS; cd07114
497978002923	NAD(P) binding site [chemical binding]; other site
497978002924	catalytic residues [active]
497978002925	hypothetical protein; Provisional; Region: PRK07064
497978002926	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
497978002927	PYR/PP interface [polypeptide binding]; other site
497978002928	dimer interface [polypeptide binding]; other site
497978002929	TPP binding site [chemical binding]; other site
497978002930	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
497978002931	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568
497978002932	TPP-binding site [chemical binding]; other site
497978002933	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
497978002934	metabolite-proton symporter; Region: 2A0106; TIGR00883
497978002935	putative substrate translocation pore; other site
497978002936	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
497978002937	active site
497978002938	catalytic residues [active]
497978002939	metal binding site [ion binding]; metal-binding site
497978002940	glutaminase; Provisional; Region: PRK00971
497978002941	Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066
497978002942	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
497978002943	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
497978002944	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
497978002945	putative substrate translocation pore; other site
497978002946	Major Facilitator Superfamily; Region: MFS_1; pfam07690
497978002947	galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019
497978002948	active site
497978002949	catalytic residues [active]
497978002950	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
497978002951	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
497978002952	The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432
497978002953	dimerization interface [polypeptide binding]; other site
497978002954	substrate binding pocket [chemical binding]; other site
497978002955	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
497978002956	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
497978002957	NAD(P) binding site [chemical binding]; other site
497978002958	active site
497978002959	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
497978002960	D-galactonate transporter; Region: 2A0114; TIGR00893
497978002961	putative substrate translocation pore; other site
497978002962	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
497978002963	TPP-binding site [chemical binding]; other site
497978002964	dimer interface [polypeptide binding]; other site
497978002965	Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958
497978002966	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
497978002967	PYR/PP interface [polypeptide binding]; other site
497978002968	dimer interface [polypeptide binding]; other site
497978002969	TPP binding site [chemical binding]; other site
497978002970	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
497978002971	B12-dependent methionine synthase; Provisional; Region: metH; PRK09490
497978002972	Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646
497978002973	MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH).  Cobalamin-dependent...; Region: MeTr; cd00740
497978002974	substrate binding pocket [chemical binding]; other site
497978002975	B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069
497978002976	B12 binding site [chemical binding]; other site
497978002977	cobalt ligand [ion binding]; other site
497978002978	Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965
497978002979	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
497978002980	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
497978002981	D-Serine dehydratase is a pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of L- or D-serine  to pyruvate and ammonia.  D-serine dehydratase serves as a detoxifying enzyme in most E. coli strains where D-serine is a competitive...; Region: D-Ser-dehyd; cd06447
497978002982	Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291
497978002983	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
497978002984	catalytic residue [active]
497978002985	Uncharacterized conserved protein [Function unknown]; Region: COG1262
497978002986	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
497978002987	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
497978002988	Sulfatase; Region: Sulfatase; pfam00884
497978002989	Rhomboid family; Region: Rhomboid; cl11446
497978002990	Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316
497978002991	IscR-regulated protein YhgI; Region: YhgI_GntY; TIGR03341
497978002992	Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694
497978002993	outer membrane receptor FepA; Provisional; Region: PRK13524
497978002994	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
497978002995	N-terminal plug; other site
497978002996	ligand-binding site [chemical binding]; other site
497978002997	Lipase.  Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883
497978002998	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
497978002999	nucleophilic elbow; other site
497978003000	catalytic triad; other site
497978003001	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378
497978003002	active site clefts [active]
497978003003	zinc binding site [ion binding]; other site
497978003004	dimer interface [polypeptide binding]; other site
497978003005	Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822
497978003006	active site
497978003007	catalytic triad [active]
497978003008	oxyanion hole [active]
497978003009	switch loop; other site
497978003010	Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG4181
497978003011	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
497978003012	Walker A/P-loop; other site
497978003013	ATP binding site [chemical binding]; other site
497978003014	Q-loop/lid; other site
497978003015	ABC transporter signature motif; other site
497978003016	Walker B; other site
497978003017	D-loop; other site
497978003018	H-loop/switch region; other site
497978003019	Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127
497978003020	FtsX-like permease family; Region: FtsX; pfam02687
497978003021	FtsX-like permease family; Region: FtsX; pfam02687
497978003022	Rhomboid family; Region: Rhomboid; pfam01694
497978003023	monofunctional biosynthetic peptidoglycan transglycosylase; Provisional; Region: mtgA; PRK00056
497978003024	Transglycosylase; Region: Transgly; cl17702
497978003025	polyphosphate kinase; Provisional; Region: PRK05443
497978003026	Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089
497978003027	Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503
497978003028	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
497978003029	putative active site [active]
497978003030	catalytic site [active]
497978003031	Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168
497978003032	putative active site [active]
497978003033	putative domain interface [polypeptide binding]; other site
497978003034	catalytic site [active]
497978003035	Sporulation related domain; Region: SPOR; cl10051
497978003036	DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151
497978003037	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
497978003038	The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411
497978003039	dimerization interface [polypeptide binding]; other site
497978003040	3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427
497978003041	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
497978003042	NADH:flavorubredoxin oxidoreductase; Provisional; Region: PRK04965
497978003043	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
497978003044	Rubredoxin [Energy production and conversion]; Region: COG1773
497978003045	Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730
497978003046	iron binding site [ion binding]; other site
497978003047	Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814
497978003048	putative hydrophobic ligand binding site [chemical binding]; other site
497978003049	Uncharacterized protein family (UPF0227); Region: UPF0227; cl14886
497978003050	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
497978003051	lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484
497978003052	LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322
497978003053	dimer interface [polypeptide binding]; other site
497978003054	putative anticodon binding site; other site
497978003055	Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775
497978003056	motif 1; other site
497978003057	active site
497978003058	motif 2; other site
497978003059	motif 3; other site
497978003060	Capsule assembly protein Wzi; Region: Caps_assemb_Wzi; pfam14052
497978003061	sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039
497978003062	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
497978003063	Active Sites [active]
497978003064	sulfate adenylyltransferase subunit 1; Provisional; Region: cysN; PRK05124
497978003065	CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166
497978003066	CysD dimerization site [polypeptide binding]; other site
497978003067	G1 box; other site
497978003068	putative GEF interaction site [polypeptide binding]; other site
497978003069	GTP/Mg2+ binding site [chemical binding]; other site
497978003070	Switch I region; other site
497978003071	G2 box; other site
497978003072	G3 box; other site
497978003073	Switch II region; other site
497978003074	G4 box; other site
497978003075	G5 box; other site
497978003076	CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695
497978003077	TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095
497978003078	Uncharacterized protein conserved in bacteria (DUF2239); Region: DUF2239; pfam09998
497978003079	H+/citrate symporter [Energy production and conversion]; Region: CitM; COG2851
497978003080	Citrate transporter; Region: CitMHS; pfam03600
497978003081	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
497978003082	Domain of unknown function DUF21; Region: DUF21; pfam01595
497978003083	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
497978003084	Transporter associated domain; Region: CorC_HlyC; smart01091
497978003085	Transcriptional regulator [Transcription]; Region: LysR; COG0583
497978003086	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
497978003087	The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417
497978003088	substrate binding pocket [chemical binding]; other site
497978003089	dimerization interface [polypeptide binding]; other site
497978003090	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
497978003091	tetramer interface [polypeptide binding]; other site
497978003092	active site
497978003093	Mg2+/Mn2+ binding site [ion binding]; other site
497978003094	isocitrate lyase; Region: PLN02892
497978003095	Uncharacterized lipoprotein NlpE involved in copper resistance [Cell envelope biogenesis, outer membrane / Inorganic ion transport and metabolism]; Region: CutF; COG3015
497978003096	NlpE N-terminal domain; Region: NlpE; pfam04170
497978003097	UreD urease accessory protein; Region: UreD; pfam01774
497978003098	Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390
497978003099	alpha-gamma subunit interface [polypeptide binding]; other site
497978003100	beta-gamma subunit interface [polypeptide binding]; other site
497978003101	Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407
497978003102	gamma-beta subunit interface [polypeptide binding]; other site
497978003103	alpha-beta subunit interface [polypeptide binding]; other site
497978003104	urease subunit alpha; Reviewed; Region: ureC; PRK13207
497978003105	Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375
497978003106	subunit interactions [polypeptide binding]; other site
497978003107	active site
497978003108	flap region; other site
497978003109	urease accessory protein UreE; Provisional; Region: ureE; PRK13261
497978003110	UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571
497978003111	dimer interface [polypeptide binding]; other site
497978003112	catalytic residues [active]
497978003113	Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830
497978003114	UreF; Region: UreF; pfam01730
497978003115	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
497978003116	HupE / UreJ protein; Region: HupE_UreJ; pfam04955
497978003117	N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742
497978003118	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
497978003119	S-adenosylmethionine binding site [chemical binding]; other site
497978003120	penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423
497978003121	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
497978003122	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
497978003123	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399
497978003124	adenylate kinase; Reviewed; Region: adk; PRK00279
497978003125	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
497978003126	AMP-binding site [chemical binding]; other site
497978003127	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
497978003128	Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177
497978003129	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
497978003130	minor groove reading motif; other site
497978003131	helix-hairpin-helix signature motif; other site
497978003132	substrate binding pocket [chemical binding]; other site
497978003133	active site
497978003134	Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576
497978003135	ferredoxin; Provisional; Region: PRK08764
497978003136	Putative Fe-S cluster; Region: FeS; cl17515
497978003137	4Fe-4S binding domain; Region: Fer4; pfam00037
497978003138	glutamate dehydrogenase; Provisional; Region: PRK09414
497978003139	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
497978003140	NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313
497978003141	NAD(P) binding site [chemical binding]; other site
497978003142	META domain; Region: META; pfam03724
497978003143	META domain; Region: META; pfam03724
497978003144	Domain of unknown function (DUF4377); Region: DUF4377; pfam14302
497978003145	The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363
497978003146	Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900
497978003147	putative active site [active]
497978003148	metal binding site [ion binding]; metal-binding site
497978003149	rRNA large subunit methyltransferase; Provisional; Region: PRK00103
497978003150	ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466
497978003151	Found in ATP-dependent protease La (LON); Region: LON; smart00464
497978003152	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
497978003153	Walker A motif; other site
497978003154	ATP binding site [chemical binding]; other site
497978003155	Walker B motif; other site
497978003156	arginine finger; other site
497978003157	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
497978003158	Extended Signal Peptide of Type V secretion system; Region: ESPR; pfam13018
497978003159	YadA-like, left-handed beta-roll; Region: LbR_YadA-like; cd12820
497978003160	trimer interface [polypeptide binding]; other site
497978003161	YadA-like, left-handed beta-roll; Region: LbR_YadA-like; cd12820
497978003162	trimer interface [polypeptide binding]; other site
497978003163	Left-handed beta-roll, including virulence factors and various other proteins; Region: LbR-like; cl17507
497978003164	trimer interface [polypeptide binding]; other site
497978003165	YadA-like, left-handed beta-roll; Region: LbR_YadA-like; cd12820
497978003166	trimer interface [polypeptide binding]; other site
497978003167	YadA-like, left-handed beta-roll; Region: LbR_YadA-like; cd12820
497978003168	trimer interface [polypeptide binding]; other site
497978003169	YadA-like C-terminal region; Region: YadA; pfam03895
497978003170	SmpA / OmlA family; Region: SmpA_OmlA; pfam04355
497978003171	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
497978003172	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
497978003173	ligand binding site [chemical binding]; other site
497978003174	5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812
497978003175	5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727
497978003176	serine hydroxymethyltransferase; Reviewed; Region: PRK13034
497978003177	Helix-turn-helix domain; Region: HTH_17; cl17695
497978003178	AAA domain; Region: AAA_24; pfam13479
497978003179	phage nucleotide-binding protein; Region: phage_P_loop; TIGR01618
497978003180	Predicted transcriptional regulator [Transcription]; Region: COG2932
497978003181	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
497978003182	Catalytic site [active]
497978003183	Bacteriophage replication protein O; Region: Phage_rep_O; cl04545
497978003184	Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277
497978003185	putative active site [active]
497978003186	Uncharacterized conserved protein (DUF2280); Region: DUF2280; pfam10045
497978003187	Terminase-like family; Region: Terminase_6; pfam03237
497978003188	Phage terminase large subunit; Region: Terminase_3; cl12054
497978003189	Domain of unknown function (DUF4055); Region: DUF4055; pfam13264
497978003190	Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072
497978003191	Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452
497978003192	Phage protein (N4 Gp49/phage Sf6 gene 66) family; Region: Phage_gp49_66; pfam13876
497978003193	phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554
497978003194	LEM-like domain of lamina-associated polypeptide 2 (LAP2) and similar proteins; Region: LEM_like; cd12935
497978003195	Bacteriophage related domain of unknown function; Region: DUF4128; pfam13554
497978003196	Bacterial SH3 domain homologues; Region: SH3b; smart00287
497978003197	DNA-binding transcriptional activator MhpR; Provisional; Region: PRK09834
497978003198	Domain of unknown function (DUF4258); Region: DUF4258; pfam14076
497978003199	Predicted transcriptional regulator [Transcription]; Region: COG2944
497978003200	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
497978003201	non-specific DNA binding site [nucleotide binding]; other site
497978003202	salt bridge; other site
497978003203	sequence-specific DNA binding site [nucleotide binding]; other site
497978003204	Phage-related minor tail protein [Function unknown]; Region: COG5281
497978003205	tape measure domain; Region: tape_meas_nterm; TIGR02675
497978003206	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
497978003207	Peptidase family M23; Region: Peptidase_M23; pfam01551
497978003208	Domain of unknown function (DUF1833); Region: DUF1833; pfam08875
497978003209	Glycosyl hydrolase 108; Region: Glyco_hydro_108; pfam05838
497978003210	Predicted Peptidoglycan domain; Region: PG_binding_3; pfam09374
497978003211	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
497978003212	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
497978003213	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
497978003214	putative metal dependent hydrolase; Provisional; Region: PRK11598
497978003215	Domain of unknown function (DUF1705); Region: DUF1705; pfam08019
497978003216	Sulfatase; Region: Sulfatase; pfam00884
497978003217	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
497978003218	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
497978003219	active site
497978003220	Int/Topo IB signature motif; other site
497978003221	DNA binding site [nucleotide binding]
497978003222	Cell division protein ZapA; Region: ZapA; pfam05164
497978003223	Uncharacterized protein family (UPF0149); Region: UPF0149; pfam03695
497978003224	Aminopeptidase P, N-terminal domain; Region: AMP_N; pfam05195
497978003225	proline aminopeptidase P II; Provisional; Region: PRK10879
497978003226	Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087
497978003227	active site
497978003228	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
497978003229	Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988
497978003230	Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988
497978003231	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
497978003232	Cd(II)/Pb(II)-responsive transcriptional regulator; Region: CadR-PbrR; TIGR02047
497978003233	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
497978003234	DNA binding residues [nucleotide binding]
497978003235	Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230
497978003236	Lysine efflux permease [General function prediction only]; Region: COG1279
497978003237	chromosome replication initiation inhibitor protein; Validated; Region: PRK03635
497978003238	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
497978003239	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
497978003240	dimerization interface [polypeptide binding]; other site
497978003241	Menaquinone biosynthesis; Region: VitK2_biosynth; cl17475
497978003242	Predicted methyltransferases [General function prediction only]; Region: COG0313
497978003243	Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648
497978003244	putative SAM binding site [chemical binding]; other site
497978003245	putative homodimer interface [polypeptide binding]; other site
497978003246	hypothetical protein; Provisional; Region: PRK14674
497978003247	Predicted periplasmic or secreted lipoprotein [General function prediction only]; Region: OsmY; COG2823
497978003248	BON domain; Region: BON; pfam04972
497978003249	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
497978003250	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
497978003251	substrate binding pocket [chemical binding]; other site
497978003252	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
497978003253	NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296
497978003254	NADH pyrophosphatase; Reviewed; Region: nudC; PRK00241
497978003255	NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297
497978003256	NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429
497978003257	putative NADH binding site [chemical binding]; other site
497978003258	putative active site [active]
497978003259	nudix motif; other site
497978003260	putative metal binding site [ion binding]; other site
497978003261	RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278
497978003262	RNA/DNA hybrid binding site [nucleotide binding]; other site
497978003263	active site
497978003264	DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406
497978003265	DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131
497978003266	active site
497978003267	catalytic site [active]
497978003268	substrate binding site [chemical binding]; other site
497978003269	membrane-bound lytic murein transglycosylase D; Provisional; Region: mltD; PRK10783
497978003270	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
497978003271	N-acetyl-D-glucosamine binding site [chemical binding]; other site
497978003272	catalytic residue [active]
497978003273	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
497978003274	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
497978003275	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
497978003276	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
497978003277	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
497978003278	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
497978003279	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
497978003280	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
497978003281	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
497978003282	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
497978003283	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
497978003284	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
497978003285	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497
497978003286	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709
497978003287	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4174
497978003288	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
497978003289	dimer interface [polypeptide binding]; other site
497978003290	conserved gate region; other site
497978003291	ABC-ATPase subunit interface; other site
497978003292	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4239
497978003293	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
497978003294	dimer interface [polypeptide binding]; other site
497978003295	conserved gate region; other site
497978003296	putative PBP binding loops; other site
497978003297	ABC-ATPase subunit interface; other site
497978003298	ABC-type uncharacterized transport system, duplicated ATPase component [General function prediction only]; Region: COG4172
497978003299	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
497978003300	Walker A/P-loop; other site
497978003301	ATP binding site [chemical binding]; other site
497978003302	Q-loop/lid; other site
497978003303	ABC transporter signature motif; other site
497978003304	Walker B; other site
497978003305	D-loop; other site
497978003306	H-loop/switch region; other site
497978003307	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
497978003308	Walker A/P-loop; other site
497978003309	ATP binding site [chemical binding]; other site
497978003310	Q-loop/lid; other site
497978003311	ABC transporter signature motif; other site
497978003312	Walker B; other site
497978003313	D-loop; other site
497978003314	H-loop/switch region; other site
497978003315	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
497978003316	Old yellow enzyme (OYE)-related FMN binding domain, group 2.  Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_2_FMN; cd04733
497978003317	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
497978003318	putative active site [active]
497978003319	putative FMN binding site [chemical binding]; other site
497978003320	putative substrate binding site [chemical binding]; other site
497978003321	putative catalytic residue [active]
497978003322	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
497978003323	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
497978003324	N-terminal plug; other site
497978003325	ligand-binding site [chemical binding]; other site
497978003326	DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847
497978003327	DEDDh 3'-5' exonuclease domain of RNase T; Region: RNaseT; cd06134
497978003328	dimer interface [polypeptide binding]; other site
497978003329	catalytic site [active]
497978003330	putative active site [active]
497978003331	putative substrate binding site [chemical binding]; other site
497978003332	Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294
497978003333	active site
497978003334	substrate binding pocket [chemical binding]; other site
497978003335	dimer interface [polypeptide binding]; other site
497978003336	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
497978003337	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
497978003338	metal binding site [ion binding]; metal-binding site
497978003339	active site
497978003340	I-site; other site
497978003341	argininosuccinate synthase; Provisional; Region: PRK13820
497978003342	Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate .  In...; Region: Argininosuccinate_Synthase; cd01999
497978003343	ANP binding site [chemical binding]; other site
497978003344	Substrate Binding Site II [chemical binding]; other site
497978003345	Substrate Binding Site I [chemical binding]; other site
497978003346	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
497978003347	2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli  is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930
497978003348	active site
497978003349	FMN binding site [chemical binding]; other site
497978003350	2,4-decadienoyl-CoA binding site; other site
497978003351	catalytic residue [active]
497978003352	4Fe-4S cluster binding site [ion binding]; other site
497978003353	Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446
497978003354	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
497978003355	Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501
497978003356	Bacterial protein of unknown function (DUF898); Region: DUF898; pfam05987
497978003357	ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464
497978003358	NLPA lipoprotein; Region: Lipoprotein_9; pfam03180
497978003359	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
497978003360	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
497978003361	Uncharacterized protein conserved in bacteria [Function unknown]; Region: VgrG; COG3501
497978003362	Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954
497978003363	Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717
497978003364	Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296
497978003365	Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; pfam10106
497978003366	RHS Repeat; Region: RHS_repeat; pfam05593
497978003367	Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209
497978003368	RHS Repeat; Region: RHS_repeat; pfam05593
497978003369	RHS Repeat; Region: RHS_repeat; pfam05593
497978003370	RHS Repeat; Region: RHS_repeat; pfam05593
497978003371	RHS Repeat; Region: RHS_repeat; cl11982
497978003372	RHS protein; Region: RHS; pfam03527
497978003373	RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696
497978003374	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
497978003375	Sel1-like repeats; Region: SEL1; smart00671
497978003376	Sel1-like repeats; Region: SEL1; smart00671
497978003377	Sel1-like repeats; Region: SEL1; smart00671
497978003378	Sel1-like repeats; Region: SEL1; smart00671
497978003379	Sel1-like repeats; Region: SEL1; smart00671
497978003380	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
497978003381	Sel1-like repeats; Region: SEL1; smart00671
497978003382	Sel1-like repeats; Region: SEL1; smart00671
497978003383	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
497978003384	Sel1 repeat; Region: Sel1; cl02723
497978003385	Sel1-like repeats; Region: SEL1; smart00671
497978003386	Sel1-like repeats; Region: SEL1; smart00671
497978003387	Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113
497978003388	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
497978003389	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
497978003390	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
497978003391	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316
497978003392	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
497978003393	Integrase core domain; Region: rve; pfam00665
497978003394	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
497978003395	Domain of unknown function (DUF3330); Region: DUF3330; pfam11809
497978003396	integrase/recombinase; Provisional; Region: PRK15417
497978003397	IntI (E2) integrases, site-specific tyrosine recombinases, DNA breaking-rejoining enzymes, N- and C-terminal domains. This CD includes integrases which are components of multiresistant integrons and mediate recombination between a proximal attI site and...; Region: INT_IntI; cd01193
497978003398	Int/Topo IB signature motif; other site
497978003399	Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523
497978003400	Siderophore biosynthesis protein domain; Region: AlcB; smart01006
497978003401	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
497978003402	Coenzyme A binding pocket [chemical binding]; other site
497978003403	Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110
497978003404	Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349
497978003405	trimer interface [polypeptide binding]; other site
497978003406	active site
497978003407	substrate binding site [chemical binding]; other site
497978003408	CoA binding site [chemical binding]; other site
497978003409	aminoglycoside resistance protein; Provisional; Region: PRK13746
497978003410	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
497978003411	active site
497978003412	NTP binding site [chemical binding]; other site
497978003413	metal binding triad [ion binding]; metal-binding site
497978003414	antibiotic binding site [chemical binding]; other site
497978003415	Domain of unknown function (DUF4111); Region: DUF4111; pfam13427
497978003416	Small Multidrug Resistance protein; Region: Multi_Drug_Res; pfam00893
497978003417	DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
497978003418	dihydropteroate synthase; Region: DHPS; TIGR01496
497978003419	substrate binding pocket [chemical binding]; other site
497978003420	dimer interface [polypeptide binding]; other site
497978003421	inhibitor binding site; inhibition site
497978003422	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
497978003423	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
497978003424	Coenzyme A binding pocket [chemical binding]; other site
497978003425	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316
497978003426	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
497978003427	Integrase core domain; Region: rve; pfam00665
497978003428	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
497978003429	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
497978003430	classical (c) SDRs; Region: SDR_c; cd05233
497978003431	short chain dehydrogenase; Provisional; Region: PRK05650
497978003432	NAD(P) binding site [chemical binding]; other site
497978003433	active site
497978003434	Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118
497978003435	Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687
497978003436	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
497978003437	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
497978003438	Pirin-related protein [General function prediction only]; Region: COG1741
497978003439	Pirin; Region: Pirin; pfam02678
497978003440	Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118
497978003441	Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687
497978003442	classical (c) SDRs; Region: SDR_c; cd05233
497978003443	short chain dehydrogenase; Provisional; Region: PRK05650
497978003444	NAD(P) binding site [chemical binding]; other site
497978003445	active site
497978003446	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
497978003447	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
497978003448	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
497978003449	Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816
497978003450	Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320
497978003451	active site
497978003452	purine riboside binding site [chemical binding]; other site
497978003453	Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038
497978003454	bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182
497978003455	RNA/DNA hybrid binding site [nucleotide binding]; other site
497978003456	active site
497978003457	carbon storage regulator; Provisional; Region: PRK01712
497978003458	aspartate kinase; Reviewed; Region: PRK06635
497978003459	AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261
497978003460	putative nucleotide binding site [chemical binding]; other site
497978003461	putative catalytic residues [active]
497978003462	putative Mg ion binding site [ion binding]; other site
497978003463	putative aspartate binding site [chemical binding]; other site
497978003464	ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913
497978003465	putative allosteric regulatory site; other site
497978003466	ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936
497978003467	alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252
497978003468	Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673
497978003469	motif 1; other site
497978003470	active site
497978003471	motif 2; other site
497978003472	motif 3; other site
497978003473	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
497978003474	DHHA1 domain; Region: DHHA1; pfam02272
497978003475	Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057
497978003476	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846
497978003477	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
497978003478	ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: PRK12421
497978003479	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
497978003480	dimer interface [polypeptide binding]; other site
497978003481	motif 1; other site
497978003482	active site
497978003483	motif 2; other site
497978003484	motif 3; other site
497978003485	Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788
497978003486	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
497978003487	Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108
497978003488	Peptidase family M48; Region: Peptidase_M48; pfam01435
497978003489	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
497978003490	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
497978003491	active site
497978003492	catalytic tetrad [active]
497978003493	DNA-binding transcriptional dual regulator Crp; Provisional; Region: PRK11753
497978003494	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
497978003495	ligand binding site [chemical binding]; other site
497978003496	flexible hinge region; other site
497978003497	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
497978003498	putative switch regulator; other site
497978003499	non-specific DNA interactions [nucleotide binding]; other site
497978003500	DNA binding site [nucleotide binding]
497978003501	sequence specific DNA binding site [nucleotide binding]; other site
497978003502	putative cAMP binding site [chemical binding]; other site
497978003503	OsmC-like protein; Region: OsmC; cl00767
497978003504	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
497978003505	Coenzyme A binding pocket [chemical binding]; other site
497978003506	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
497978003507	Peptidase family M23; Region: Peptidase_M23; pfam01551
497978003508	ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346
497978003509	Clp amino terminal domain; Region: Clp_N; pfam02861
497978003510	Clp amino terminal domain; Region: Clp_N; pfam02861
497978003511	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
497978003512	Walker A motif; other site
497978003513	ATP binding site [chemical binding]; other site
497978003514	Walker B motif; other site
497978003515	arginine finger; other site
497978003516	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
497978003517	Walker A motif; other site
497978003518	ATP binding site [chemical binding]; other site
497978003519	Walker B motif; other site
497978003520	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
497978003521	Competence-damaged protein; Region: CinA; pfam02464
497978003522	23S rRNA m(2)G2445 methyltransferase; Provisional; Region: rlmL; PRK11783
497978003523	THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715
497978003524	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
497978003525	DNA methylase; Region: N6_N4_Mtase; cl17433
497978003526	aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856
497978003527	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
497978003528	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
497978003529	dihydroorotase; Validated; Region: pyrC; PRK09357
497978003530	Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317
497978003531	active site
497978003532	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
497978003533	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
497978003534	ligand binding site [chemical binding]; other site
497978003535	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807
497978003536	Domain of unknown function (DUF2520); Region: DUF2520; pfam10728
497978003537	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
497978003538	GST_N family, unknown subfamily 2; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_2; cd03047
497978003539	putative C-terminal domain interface [polypeptide binding]; other site
497978003540	putative GSH binding site (G-site) [chemical binding]; other site
497978003541	putative dimer interface [polypeptide binding]; other site
497978003542	C-terminal, alpha helical domain of an unknown subfamily 2 of Glutathione S-transferases; Region: GST_C_2; cd03180
497978003543	putative N-terminal domain interface [polypeptide binding]; other site
497978003544	putative dimer interface [polypeptide binding]; other site
497978003545	putative substrate binding pocket (H-site) [chemical binding]; other site
497978003546	tRNA (guanine-N(7)-)-methyltransferase; Reviewed; Region: trmB; PRK00121
497978003547	Predicted extracellular nuclease [General function prediction only]; Region: COG2374
497978003548	YhcR_OBF_like: A subfamily of OB-fold domains similar to the OB folds of Bacillus subtilis YhcR. YhcR is a sugar-nonspecific nuclease, which is active in the presence of Ca2+ and Mn2+. It cleaves RNA endonucleolytically, producing 3'-monophosphate...; Region: YhcR_OBF_like; cd04486
497978003549	generic binding surface II; other site
497978003550	generic binding surface I; other site
497978003551	Mycoplasma pulmonis MnuA nuclease-like; Region: MnuA_DNase1-like; cd10283
497978003552	putative active site [active]
497978003553	putative catalytic site [active]
497978003554	putative Mg binding site IVb [ion binding]; other site
497978003555	putative phosphate binding site [ion binding]; other site
497978003556	putative DNA binding site [nucleotide binding]; other site
497978003557	putative Mg binding site IVa [ion binding]; other site
497978003558	glutathionine S-transferase; Provisional; Region: PRK10542
497978003559	GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057
497978003560	C-terminal domain interface [polypeptide binding]; other site
497978003561	GSH binding site (G-site) [chemical binding]; other site
497978003562	dimer interface [polypeptide binding]; other site
497978003563	C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188
497978003564	dimer interface [polypeptide binding]; other site
497978003565	N-terminal domain interface [polypeptide binding]; other site
497978003566	substrate binding pocket (H-site) [chemical binding]; other site
497978003567	alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317
497978003568	Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974
497978003569	catalytic residue [active]
497978003570	TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026
497978003571	catalytic residues [active]
497978003572	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
497978003573	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
497978003574	Protein of unknown function (DUF1653); Region: DUF1653; pfam07866
497978003575	Predicted O-methyltransferase [General function prediction only]; Region: COG4122
497978003576	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
497978003577	S-adenosylmethionine binding site [chemical binding]; other site
497978003578	KTSC domain; Region: KTSC; pfam13619
497978003579	peroxiredoxin; Region: AhpC; TIGR03137
497978003580	Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015
497978003581	dimer interface [polypeptide binding]; other site
497978003582	decamer (pentamer of dimers) interface [polypeptide binding]; other site
497978003583	catalytic triad [active]
497978003584	peroxidatic and resolving cysteines [active]
497978003585	ATP-dependent helicase HrpA; Region: DEAH_box_HrpA; TIGR01967
497978003586	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
497978003587	ATP binding site [chemical binding]; other site
497978003588	putative Mg++ binding site [ion binding]; other site
497978003589	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
497978003590	nucleotide binding region [chemical binding]; other site
497978003591	ATP-binding site [chemical binding]; other site
497978003592	Helicase associated domain (HA2); Region: HA2; pfam04408
497978003593	Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717
497978003594	Domain of unknown function (DUF3418); Region: DUF3418; pfam11898
497978003595	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK07515
497978003596	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
497978003597	dimer interface [polypeptide binding]; other site
497978003598	active site
497978003599	CoA binding pocket [chemical binding]; other site
497978003600	outer membrane porin, OprD family; Region: OprD; pfam03573
497978003601	benzoate transport; Region: 2A0115; TIGR00895
497978003602	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
497978003603	putative substrate translocation pore; other site
497978003604	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
497978003605	putative substrate translocation pore; other site
497978003606	benzoate transporter; Region: benE; TIGR00843
497978003607	Benzoate membrane transport protein; Region: BenE; pfam03594
497978003608	1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate dehydrogenase; Provisional; Region: benD; PRK12823
497978003609	1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate dehydrogenase (DHB DH)-like, classical (c) SDR; Region: DHB_DH-like_SDR_c; cd08937
497978003610	putative NAD(P) binding site [chemical binding]; other site
497978003611	active site
497978003612	anthranilate dioxygenase reductase; Provisional; Region: antC; PRK11872
497978003613	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
497978003614	catalytic loop [active]
497978003615	iron binding site [ion binding]; other site
497978003616	Benzoate dioxygenase reductase (BenDO) FAD/NAD binding domain. Oxygenases oxidize hydrocarbons using dioxygen as the oxidant. As a Class I bacterial dioxygenases, benzoate dioxygenase like proteins combine an [2Fe-2S] cluster containing N-terminal...; Region: BenDO_FAD_NAD; cd06209
497978003617	FAD binding pocket [chemical binding]; other site
497978003618	FAD binding motif [chemical binding]; other site
497978003619	phosphate binding motif [ion binding]; other site
497978003620	beta-alpha-beta structure motif; other site
497978003621	NAD binding pocket [chemical binding]; other site
497978003622	Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667
497978003623	inter-subunit interface; other site
497978003624	benzoate 1,2-dioxygenase, large subunit; Region: benzo_1_2_benA; TIGR03229
497978003625	Rieske non-heme iron oxygenase (RO) family, 2-Halobenzoate 1,2-dioxygenase (HBDO) subfamily, N-terminal Rieske domain of the oxygenase alpha subunit; ROs comprise a large class of aromatic ring-hydroxylating dioxygenases that enable microorganisms to...; Region: Rieske_RO_Alpha_HBDO; cd03542
497978003626	C-terminal catalytic domain of the oxygenase alpha subunit of Pseudomonas resinovorans strain CA10 anthranilate 1,2-dioxygenase and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_AntDO-like; cd08879
497978003627	putative alpha subunit interface [polypeptide binding]; other site
497978003628	putative active site [active]
497978003629	putative substrate binding site [chemical binding]; other site
497978003630	Fe binding site [ion binding]; other site
497978003631	DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906
497978003632	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
497978003633	The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in benzoate catabolism; contains the type 2 periplasmic binding fold; Region: PBP2_BenM_CatM_CatR; cd08445
497978003634	dimerizarion interface [polypeptide binding]; other site
497978003635	CrgA pocket; other site
497978003636	substrate binding pocket [chemical binding]; other site
497978003637	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
497978003638	metal-binding site [ion binding]
497978003639	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
497978003640	metal-binding site [ion binding]
497978003641	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
497978003642	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
497978003643	metal-binding site [ion binding]
497978003644	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
497978003645	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
497978003646	motif II; other site
497978003647	Cu(I)-responsive transcriptional regulator; Region: CueR; TIGR02044
497978003648	Helix-Turn-Helix DNA binding domain of CueR-like transcription regulators; Region: HTH_CueR; cd01108
497978003649	DNA binding residues [nucleotide binding]
497978003650	dimer interface [polypeptide binding]; other site
497978003651	copper binding site [ion binding]; other site
497978003652	Glutathione-dependent formaldehyde-activating enzyme; Region: GFA; pfam04828
497978003653	Cysteine-rich 4 helical bundle widely conserved in bacteria; Region: DUF326; cd08026
497978003654	dimerization interface [polypeptide binding]; other site
497978003655	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
497978003656	exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286
497978003657	ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489
497978003658	generic binding surface II; other site
497978003659	generic binding surface I; other site
497978003660	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
497978003661	Predicted transcriptional regulator [Transcription]; Region: COG2932
497978003662	non-specific DNA binding site [nucleotide binding]; other site
497978003663	salt bridge; other site
497978003664	sequence-specific DNA binding site [nucleotide binding]; other site
497978003665	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
497978003666	Catalytic site [active]
497978003667	Glycosyl hydrolase 108; Region: Glyco_hydro_108; pfam05838
497978003668	Predicted Peptidoglycan domain; Region: PG_binding_3; pfam09374
497978003669	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
497978003670	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
497978003671	DNA-binding site [nucleotide binding]; DNA binding site
497978003672	RNA-binding motif; other site
497978003673	pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880
497978003674	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232
497978003675	Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072
497978003676	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
497978003677	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
497978003678	putative substrate translocation pore; other site
497978003679	Predicted transcriptional regulators [Transcription]; Region: COG1733
497978003680	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
497978003681	Predicted Peptidoglycan domain; Region: PG_binding_3; pfam09374
497978003682	Domain of unknown function (DUF4142); Region: DUF4142; pfam13628
497978003683	cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260
497978003684	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
497978003685	active site
497978003686	HIGH motif; other site
497978003687	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
497978003688	KMSKS motif; other site
497978003689	Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963
497978003690	tRNA binding surface [nucleotide binding]; other site
497978003691	anticodon binding site; other site
497978003692	D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892
497978003693	KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014
497978003694	putative active site [active]
497978003695	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein.  These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604
497978003696	HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662
497978003697	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
497978003698	active site
497978003699	motif I; other site
497978003700	motif II; other site
497978003701	Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835
497978003702	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3117; cl01200
497978003703	lipopolysaccharide transport periplasmic protein LptA; Region: outer_YhbN_LptA; TIGR03002
497978003704	OstA-like protein; Region: OstA; pfam03968
497978003705	ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137
497978003706	ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218
497978003707	Walker A/P-loop; other site
497978003708	ATP binding site [chemical binding]; other site
497978003709	Q-loop/lid; other site
497978003710	ABC transporter signature motif; other site
497978003711	Walker B; other site
497978003712	D-loop; other site
497978003713	H-loop/switch region; other site
497978003714	type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844
497978003715	type I secretion system ATPase, LssB family; Region: type_I_sec_LssB; TIGR03375
497978003716	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
497978003717	ATP-binding cassette domain of bacteriocin exporters, subfamily C; Region: ABCC_bacteriocin_exporters; cd03245
497978003718	Walker A/P-loop; other site
497978003719	ATP binding site [chemical binding]; other site
497978003720	Q-loop/lid; other site
497978003721	ABC transporter signature motif; other site
497978003722	Walker B; other site
497978003723	D-loop; other site
497978003724	H-loop/switch region; other site
497978003725	type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843
497978003726	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
497978003727	HlyD family secretion protein; Region: HlyD_3; pfam13437
497978003728	Uncharacterized conserved protein [Function unknown]; Region: COG1739
497978003729	Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205
497978003730	Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110
497978003731	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
497978003732	putative trimer interface [polypeptide binding]; other site
497978003733	Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647
497978003734	trimer interface [polypeptide binding]; other site
497978003735	active site
497978003736	substrate binding site [chemical binding]; other site
497978003737	putative CoA binding site [chemical binding]; other site
497978003738	CoA binding site [chemical binding]; other site
497978003739	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
497978003740	Ligand Binding Site [chemical binding]; other site
497978003741	Predicted O-methyltransferase [General function prediction only]; Region: COG4122
497978003742	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
497978003743	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3108
497978003744	Ferredoxin [Energy production and conversion]; Region: COG1146
497978003745	4Fe-4S binding domain; Region: Fer4; cl02805
497978003746	Domain of unknown function (DUF3470); Region: DUF3470; pfam11953
497978003747	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
497978003748	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
497978003749	Coenzyme A binding pocket [chemical binding]; other site
497978003750	DNA mismatch repair protein MutS; Provisional; Region: PRK05399
497978003751	MutS domain I; Region: MutS_I; pfam01624
497978003752	MutS domain II; Region: MutS_II; pfam05188
497978003753	MutS domain III; Region: MutS_III; pfam05192
497978003754	MutS domain V; Region: MutS_V; pfam00488
497978003755	Walker A/P-loop; other site
497978003756	ATP binding site [chemical binding]; other site
497978003757	Q-loop/lid; other site
497978003758	ABC transporter signature motif; other site
497978003759	Walker B; other site
497978003760	D-loop; other site
497978003761	H-loop/switch region; other site
497978003762	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
497978003763	AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404
497978003764	AsnC family; Region: AsnC_trans_reg; pfam01037
497978003765	Threonine/homoserine efflux transporter [Amino acid transport and metabolism]; Region: rhtA; COG5006
497978003766	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
497978003767	Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279
497978003768	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
497978003769	putative acyl-acceptor binding pocket; other site
497978003770	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
497978003771	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
497978003772	benzoate transport; Region: 2A0115; TIGR00895
497978003773	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
497978003774	putative substrate translocation pore; other site
497978003775	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
497978003776	Uncharacterized protein conserved in bacteria (DUF2147); Region: DUF2147; pfam09917
497978003777	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
497978003778	Helix-Turn-Helix DNA binding domain of the transcription regulators NolA and AlbR; Region: HTH_NolA-AlbR; cd04788
497978003779	DNA binding residues [nucleotide binding]
497978003780	putative dimer interface [polypeptide binding]; other site
497978003781	TipAS antibiotic-recognition domain; Region: TipAS; pfam07739
497978003782	TipAS antibiotic-recognition domain; Region: TipAS; pfam07739
497978003783	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
497978003784	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
497978003785	Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508
497978003786	Coenzyme A binding pocket [chemical binding]; other site
497978003787	Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419
497978003788	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
497978003789	motif II; other site
497978003790	Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354
497978003791	Uncharacterized protein conserved in bacteria [Function unknown]; Region: VgrG; COG3501
497978003792	Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954
497978003793	Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717
497978003794	Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296
497978003795	Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; pfam10106
497978003796	RHS Repeat; Region: RHS_repeat; pfam05593
497978003797	Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209
497978003798	RHS Repeat; Region: RHS_repeat; pfam05593
497978003799	RHS Repeat; Region: RHS_repeat; pfam05593
497978003800	RHS Repeat; Region: RHS_repeat; pfam05593
497978003801	RHS Repeat; Region: RHS_repeat; pfam05593
497978003802	RHS Repeat; Region: RHS_repeat; pfam05593
497978003803	RHS protein; Region: RHS; pfam03527
497978003804	RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696
497978003805	transcriptional regulator, ArgP family; Region: argP; TIGR03298
497978003806	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
497978003807	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
497978003808	dimerization interface [polypeptide binding]; other site
497978003809	Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914
497978003810	LamB/YcsF family of  lactam utilization protein; Region: LamB_YcsF_like; cd10787
497978003811	putative active site [active]
497978003812	hypothetical protein; Provisional; Region: PRK05463
497978003813	Allophanate hydrolase subunit 1; Region: AHS1; pfam02682
497978003814	Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896
497978003815	Allophanate hydrolase subunit 2; Region: AHS2; pfam02626
497978003816	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
497978003817	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
497978003818	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
497978003819	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
497978003820	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
497978003821	carboxyltransferase (CT) interaction site; other site
497978003822	biotinylation site [posttranslational modification]; other site
497978003823	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
497978003824	ClC sycA-like chloride channel proteins. This ClC family presents in bacteria, where it facilitates acid resistance in acidic soil. Mutation of this gene (sycA) in Rhizobium tropici CIAT899 causes serious deficiencies in nodule development, nodulation...; Region: ClC_sycA_like; cd03682
497978003825	putative Cl- selectivity filter; other site
497978003826	putative pore gating glutamate residue; other site
497978003827	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
497978003828	Sel1-like repeats; Region: SEL1; smart00671
497978003829	Sel1-like repeats; Region: SEL1; smart00671
497978003830	Sel1-like repeats; Region: SEL1; smart00671
497978003831	Sel1-like repeats; Region: SEL1; smart00671
497978003832	Sel1-like repeats; Region: SEL1; smart00671
497978003833	Sel1-like repeats; Region: SEL1; smart00671
497978003834	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
497978003835	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
497978003836	Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821
497978003837	putative hydrophobic ligand binding site [chemical binding]; other site
497978003838	protein interface [polypeptide binding]; other site
497978003839	gate; other site
497978003840	Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283
497978003841	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
497978003842	NAD binding site [chemical binding]; other site
497978003843	catalytic Zn binding site [ion binding]; other site
497978003844	structural Zn binding site [ion binding]; other site
497978003845	urea carboxylase-associated protein 1; Region: urea_degr_1; TIGR03424
497978003846	urea carboxylase-associated protein 2; Region: urea_degr_2; TIGR03425
497978003847	urea carboxylase-associated protein 1; Region: urea_degr_1; TIGR03424
497978003848	Domain of unknown function (DUF1989); Region: DUF1989; pfam09347
497978003849	urea carboxylase; Region: urea_carbox; TIGR02712
497978003850	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
497978003851	ATP-grasp domain; Region: ATP-grasp_4; cl17255
497978003852	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
497978003853	Allophanate hydrolase subunit 2; Region: AHS2; smart00797
497978003854	Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896
497978003855	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
497978003856	carboxyltransferase (CT) interaction site; other site
497978003857	biotinylation site [posttranslational modification]; other site
497978003858	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
497978003859	Predicted transcriptional regulators [Transcription]; Region: COG1733
497978003860	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
497978003861	nickel responsive regulator; Provisional; Region: PRK04460
497978003862	NikR C terminal nickel binding domain; Region: NikR_C; pfam08753
497978003863	allophanate hydrolase; Provisional; Region: PRK08186
497978003864	Amidase; Region: Amidase; cl11426
497978003865	ABC transporter periplasmic binding protein, urea carboxylase region; Region: ABC_peri_uca; TIGR03427
497978003866	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
497978003867	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
497978003868	Walker A/P-loop; other site
497978003869	ATP binding site [chemical binding]; other site
497978003870	Q-loop/lid; other site
497978003871	ABC transporter signature motif; other site
497978003872	Walker B; other site
497978003873	D-loop; other site
497978003874	H-loop/switch region; other site
497978003875	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
497978003876	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
497978003877	dimer interface [polypeptide binding]; other site
497978003878	conserved gate region; other site
497978003879	putative PBP binding loops; other site
497978003880	ABC-ATPase subunit interface; other site
497978003881	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4460
497978003882	Protein of unknown function (DUF770); Region: DUF770; pfam05591
497978003883	Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and    vesicular transport]; Region: COG3517; cl05484
497978003884	Protein of unknown function (DUF877); Region: DUF877; pfam05943
497978003885	Protein of unknown function (DUF796); Region: DUF796; pfam05638
497978003886	type VI secretion system lysozyme-like protein; Region: VI_zyme; TIGR03357
497978003887	Type VI protein secretion system component VasA [Intracellular trafficking, secretion, and    vesicular transport]; Region: COG3519
497978003888	Bacterial protein of unknown function (DUF879); Region: DUF879; cl15462
497978003889	Protein of unknown function (DUF1305); Region: DUF1305; pfam06996
497978003890	Type VI protein secretion system component VasK [Intracellular trafficking, secretion, and    vesicular transport]; Region: IcmF; COG3523
497978003891	Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761
497978003892	Protein of unknown function (DUF1215); Region: DUF1215; pfam06744
497978003893	Uncharacterized protein conserved in bacteria (DUF2094); Region: DUF2094; cl01611
497978003894	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
497978003895	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
497978003896	ligand binding site [chemical binding]; other site
497978003897	PAAR motif; Region: PAAR_motif; pfam05488
497978003898	type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345
497978003899	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
497978003900	Walker A motif; other site
497978003901	ATP binding site [chemical binding]; other site
497978003902	Walker B motif; other site
497978003903	arginine finger; other site
497978003904	JNK_SAPK-associated protein-1; Region: Jnk-SapK_ap_N; pfam09744
497978003905	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
497978003906	Walker A motif; other site
497978003907	ATP binding site [chemical binding]; other site
497978003908	Walker B motif; other site
497978003909	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
497978003910	type VI secretion-associated protein, ImpA family; Region: VI_chp_8; TIGR03363
497978003911	ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812
497978003912	type VI secretion protein, VC_A0114 family; Region: VI_chp_4; TIGR03353
497978003913	Bacterial protein of unknown function (DUF876); Region: DUF876; pfam05936
497978003914	type IV / VI secretion system protein, DotU family; Region: IV_VI_DotU; TIGR03349
497978003915	D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557
497978003916	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_M15_4; pfam13539
497978003917	Transcriptional regulator [Transcription]; Region: LysR; COG0583
497978003918	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
497978003919	LysR substrate binding domain; Region: LysR_substrate; pfam03466
497978003920	dimerization interface [polypeptide binding]; other site
497978003921	Ankyrin repeats (many copies); Region: Ank_4; pfam13637
497978003922	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
497978003923	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
497978003924	Ankyrin repeats (many copies); Region: Ank_4; pfam13637
497978003925	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
497978003926	nucleoside/Zn binding site; other site
497978003927	dimer interface [polypeptide binding]; other site
497978003928	catalytic motif [active]
497978003929	putative cyanate transporter; Provisional; Region: cynX; PRK09705
497978003930	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
497978003931	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214
497978003932	Protein of unknown function (DUF1006); Region: DUF1006; pfam06224
497978003933	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
497978003934	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
497978003935	Coenzyme A binding pocket [chemical binding]; other site
497978003936	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1636
497978003937	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
497978003938	redox-sensitive transcriptional activator SoxR; Region: SoxR; TIGR01950
497978003939	Helix-Turn-Helix DNA binding domain of the SoxR transcription regulator; Region: HTH_SoxR; cd01110
497978003940	DNA binding residues [nucleotide binding]
497978003941	dimer interface [polypeptide binding]; other site
497978003942	[2Fe-2S] cluster binding site [ion binding]; other site
497978003943	Putative hemolysin [General function prediction only]; Region: Hlx; COG3042
497978003944	Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139
497978003945	Domain of unknown function (DUF333); Region: DUF333; pfam03891
497978003946	Peptidase inhibitor I78 family; Region: Inhibitor_I78; pfam11720
497978003947	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
497978003948	Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408
497978003949	inhibitor site; inhibition site
497978003950	active site
497978003951	dimer interface [polypeptide binding]; other site
497978003952	catalytic residue [active]
497978003953	EamA-like transporter family; Region: EamA; pfam00892
497978003954	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
497978003955	Transcriptional regulators [Transcription]; Region: GntR; COG1802
497978003956	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
497978003957	DNA-binding site [nucleotide binding]; DNA binding site
497978003958	FCD domain; Region: FCD; pfam07729
497978003959	hydroxyproline-2-epimerase; Provisional; Region: PRK13970
497978003960	hydroxyproline-2-epimerase; Provisional; Region: PRK13971
497978003961	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
497978003962	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
497978003963	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510
497978003964	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992
497978003965	PAS fold; Region: PAS_4; pfam08448
497978003966	Helix-turn-helix domain; Region: HTH_18; pfam12833
497978003967	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
497978003968	metabolite-proton symporter; Region: 2A0106; TIGR00883
497978003969	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
497978003970	putative substrate translocation pore; other site
497978003971	NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012
497978003972	Alpha-Ketoglutaric Semialdehyde Dehydrogenase; Region: ALDH_KGSADH; cd07129
497978003973	dimer interface [polypeptide binding]; other site
497978003974	NADP binding site [chemical binding]; other site
497978003975	catalytic residues [active]
497978003976	amino acid transporter; Region: 2A0306; TIGR00909
497978003977	L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720
497978003978	Serine dehydratase beta chain; Region: SDH_beta; pfam03315
497978003979	Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313
497978003980	bifunctional aldehyde dehydrogenase/enoyl-CoA hydratase; Provisional; Region: PRK11563
497978003981	N-terminal domain of the monoamine oxidase C dehydratase; Region: ALDH_MaoC-N; cd07128
497978003982	substrate binding site [chemical binding]; other site
497978003983	dimer interface [polypeptide binding]; other site
497978003984	NADP binding site [chemical binding]; other site
497978003985	catalytic residues [active]
497978003986	MaoC_C  The C-terminal hot dog fold of the MaoC (monoamine oxidase C) dehydratase regulatory protein. Orthologs of MaoC include PaaZ [Escherichia coli] and PaaN [Pseudomonas putida], which are putative ring-opening enzymes involved in phenylacetic acid...; Region: MaoC_C; cd03452
497978003987	substrate binding site [chemical binding]; other site
497978003988	phenylacetate-CoA oxygenase subunit PaaA; Provisional; Region: paaA; PRK13778
497978003989	phenylacetate-CoA oxygenase, PaaG subunit; Region: PA_CoA_Oxy1; TIGR02156
497978003990	phenylacetate-CoA oxygenase subunit PaaB; Provisional; Region: paaB; PRK13781
497978003991	Phenylacetic acid catabolic protein; Region: PaaA_PaaC; pfam05138
497978003992	Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151
497978003993	phenylacetate-CoA oxygenase, PaaJ subunit; Region: PA_CoA_Oxy4; TIGR02159
497978003994	phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160
497978003995	NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214
497978003996	FAD binding pocket [chemical binding]; other site
497978003997	FAD binding motif [chemical binding]; other site
497978003998	phosphate binding motif [ion binding]; other site
497978003999	beta-alpha-beta structure motif; other site
497978004000	NAD(p) ribose binding residues [chemical binding]; other site
497978004001	NAD binding pocket [chemical binding]; other site
497978004002	NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site
497978004003	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
497978004004	catalytic loop [active]
497978004005	iron binding site [ion binding]; other site
497978004006	enoyl-CoA hydratase-isomerase; Provisional; Region: PRK09674
497978004007	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
497978004008	substrate binding site [chemical binding]; other site
497978004009	oxyanion hole (OAH) forming residues; other site
497978004010	trimer interface [polypeptide binding]; other site
497978004011	enoyl-CoA hydratase; Provisional; Region: PRK08140
497978004012	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
497978004013	substrate binding site [chemical binding]; other site
497978004014	oxyanion hole (OAH) forming residues; other site
497978004015	trimer interface [polypeptide binding]; other site
497978004016	3-hydroxy-acyl-CoA dehydrogenase; Validated; Region: PRK08268
497978004017	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
497978004018	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
497978004019	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
497978004020	beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050
497978004021	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
497978004022	dimer interface [polypeptide binding]; other site
497978004023	active site
497978004024	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
497978004025	phenylacetate-CoA ligase; Region: PA_CoA_ligase; TIGR02155
497978004026	acyl-activating enzyme (AAE) consensus motif; other site
497978004027	AMP binding site [chemical binding]; other site
497978004028	active site
497978004029	CoA binding site [chemical binding]; other site
497978004030	PaaX-like protein; Region: PaaX; pfam07848
497978004031	phenylacetic acid degradation operon negative regulatory protein PaaX; Region: PaaX_trns_reg; TIGR02277
497978004032	PaaX-like protein C-terminal domain; Region: PaaX_C; pfam08223
497978004033	phenylacetic acid degradation protein PaaY; Region: PaaY; TIGR02287
497978004034	paaY-like: This group is composed by uncharacterized proteins with similarity to the protein product of the E. coli paaY gene, which is part of the paa gene cluster responsible for phenylacetic acid degradation. Proteins in this group are expected to...; Region: LbH_paaY_like; cd04745
497978004035	putative trimer interface [polypeptide binding]; other site
497978004036	putative metal binding site [ion binding]; other site
497978004037	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
497978004038	CoenzymeA binding site [chemical binding]; other site
497978004039	subunit interaction site [polypeptide binding]; other site
497978004040	PHB binding site; other site
497978004041	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
497978004042	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
497978004043	putative active site [active]
497978004044	putative NTP binding site [chemical binding]; other site
497978004045	putative nucleic acid binding site [nucleotide binding]; other site
497978004046	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
497978004047	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
497978004048	Catalase-like heme-binding proteins similar to the uncharacterized srpA; Region: srpA_like; cd08153
497978004049	putative heme binding pocket [chemical binding]; other site
497978004050	Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038
497978004051	Uncharacterized conserved protein [Function unknown]; Region: COG5470
497978004052	Transcriptional regulators [Transcription]; Region: GntR; COG1802
497978004053	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
497978004054	DNA-binding site [nucleotide binding]; DNA binding site
497978004055	FCD domain; Region: FCD; cl11656
497978004056	Amino acid synthesis; Region: AA_synth; pfam06684
497978004057	Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303
497978004058	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
497978004059	Flavin reductase like domain; Region: Flavin_Reduct; smart00903
497978004060	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
497978004061	Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296
497978004062	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
497978004063	Uncharacterized Candidatus pelagibacter aldehyde dehydrogenase, DhaS-like; Region: ALDH_DhaS; cd07114
497978004064	NAD(P) binding site [chemical binding]; other site
497978004065	catalytic residues [active]
497978004066	Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456
497978004067	Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133
497978004068	succinic semialdehyde dehydrogenase; Region: PLN02278
497978004069	Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103
497978004070	tetramerization interface [polypeptide binding]; other site
497978004071	NAD(P) binding site [chemical binding]; other site
497978004072	catalytic residues [active]
497978004073	Carboxymuconolactone decarboxylase family; Region: CMD; cl00460
497978004074	Transcriptional regulator [Transcription]; Region: LysR; COG0583
497978004075	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
497978004076	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_6; cd08475
497978004077	putative effector binding pocket; other site
497978004078	putative dimerization interface [polypeptide binding]; other site
497978004079	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
497978004080	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
497978004081	beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Region: pcaR_pcaU; TIGR02431
497978004082	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
497978004083	Bacterial transcriptional regulator; Region: IclR; pfam01614
497978004084	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
497978004085	4-hydroxybenzoate 3-monooxygenase; Validated; Region: PRK08243
497978004086	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
497978004087	transcriptional regulator protein; Region: phnR; TIGR03337
497978004088	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
497978004089	DNA-binding site [nucleotide binding]; DNA binding site
497978004090	UTRA domain; Region: UTRA; pfam07702
497978004091	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
497978004092	ABC-type thiamine transport system, periplasmic component [Coenzyme metabolism]; Region: TbpA; COG4143
497978004093	putative 2-aminoethylphosphonate ABC transporter, ATP-binding protein; Region: PhnT2; TIGR03265
497978004094	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
497978004095	Walker A/P-loop; other site
497978004096	ATP binding site [chemical binding]; other site
497978004097	Q-loop/lid; other site
497978004098	ABC transporter signature motif; other site
497978004099	Walker B; other site
497978004100	D-loop; other site
497978004101	H-loop/switch region; other site
497978004102	putative 2-aminoethylphosphonate ABC transporter, permease protein; Region: PhnU2; TIGR03262
497978004103	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
497978004104	dimer interface [polypeptide binding]; other site
497978004105	conserved gate region; other site
497978004106	putative PBP binding loops; other site
497978004107	ABC-ATPase subunit interface; other site
497978004108	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
497978004109	dimer interface [polypeptide binding]; other site
497978004110	conserved gate region; other site
497978004111	putative PBP binding loops; other site
497978004112	ABC-ATPase subunit interface; other site
497978004113	FAD dependent oxidoreductase TIGR03364; Region: HpnW_proposed
497978004114	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
497978004115	2-aminoethylphosphonate--pyruvate transaminase; Provisional; Region: PRK13479
497978004116	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
497978004117	catalytic residue [active]
497978004118	phosphonoacetaldehyde hydrolase; Provisional; Region: PRK13478
497978004119	benzoate transport; Region: 2A0115; TIGR00895
497978004120	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
497978004121	putative substrate translocation pore; other site
497978004122	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
497978004123	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
497978004124	active site
497978004125	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
497978004126	CoA-transferase family III; Region: CoA_transf_3; pfam02515
497978004127	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
497978004128	Transcriptional regulator [Transcription]; Region: IclR; COG1414
497978004129	Bacterial transcriptional regulator; Region: IclR; pfam01614
497978004130	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
497978004131	enoyl-CoA hydratase; Provisional; Region: PRK06688
497978004132	substrate binding site [chemical binding]; other site
497978004133	oxyanion hole (OAH) forming residues; other site
497978004134	trimer interface [polypeptide binding]; other site
497978004135	Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070
497978004136	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
497978004137	FMN binding site [chemical binding]; other site
497978004138	substrate binding site [chemical binding]; other site
497978004139	putative catalytic residue [active]
497978004140	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
497978004141	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
497978004142	putative substrate translocation pore; other site
497978004143	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
497978004144	Transcriptional regulator [Transcription]; Region: IclR; COG1414
497978004145	Bacterial transcriptional regulator; Region: IclR; pfam01614
497978004146	acetyl-CoA acetyltransferase; Provisional; Region: PRK08131
497978004147	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
497978004148	dimer interface [polypeptide binding]; other site
497978004149	active site
497978004150	3-hydroxy-acyl-CoA dehydrogenase; Validated; Region: PRK08268
497978004151	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
497978004152	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
497978004153	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
497978004154	3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826
497978004155	classical (c) SDRs; Region: SDR_c; cd05233
497978004156	NAD(P) binding site [chemical binding]; other site
497978004157	active site
497978004158	enoyl-CoA hydratase; Provisional; Region: PRK08138
497978004159	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
497978004160	substrate binding site [chemical binding]; other site
497978004161	oxyanion hole (OAH) forming residues; other site
497978004162	trimer interface [polypeptide binding]; other site
497978004163	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
497978004164	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
497978004165	active site
497978004166	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
497978004167	benzoate transport; Region: 2A0115; TIGR00895
497978004168	putative substrate translocation pore; other site
497978004169	3-oxoacid CoA-transferase, A subunit; Region: pcaI_scoA_fam; TIGR02429
497978004170	3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428
497978004171	Maltoporin periplasmic N-terminal extension; Region: Sugarporin_N; pfam11471
497978004172	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
497978004173	Major Facilitator Superfamily; Region: MFS_1; pfam07690
497978004174	putative substrate translocation pore; other site
497978004175	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
497978004176	CoenzymeA binding site [chemical binding]; other site
497978004177	subunit interaction site [polypeptide binding]; other site
497978004178	PHB binding site; other site
497978004179	Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418
497978004180	acyl-CoA dehydrogenase; Provisional; Region: PTZ00456
497978004181	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
497978004182	active site
497978004183	Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806
497978004184	Thioesterase-like superfamily; Region: 4HBT_3; pfam13622
497978004185	indolepyruvate ferredoxin oxidoreductase; Validated; Region: PRK09193
497978004186	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
497978004187	dimer interface [polypeptide binding]; other site
497978004188	PYR/PP interface [polypeptide binding]; other site
497978004189	TPP binding site [chemical binding]; other site
497978004190	substrate binding site [chemical binding]; other site
497978004191	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629
497978004192	TPP-binding site [chemical binding]; other site
497978004193	Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014
497978004194	Transcriptional regulator [Transcription]; Region: LysR; COG0583
497978004195	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
497978004196	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
497978004197	putative effector binding pocket; other site
497978004198	dimerization interface [polypeptide binding]; other site
497978004199	Isopropylmalate/homocitrate/citramalate synthases [Amino acid transport and metabolism]; Region: LeuA; COG0119
497978004200	3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938
497978004201	active site
497978004202	catalytic residues [active]
497978004203	metal binding site [ion binding]; metal-binding site
497978004204	Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770
497978004205	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
497978004206	ATP-grasp domain; Region: ATP-grasp_4; cl17255
497978004207	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
497978004208	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
497978004209	carboxyltransferase (CT) interaction site; other site
497978004210	biotinylation site [posttranslational modification]; other site
497978004211	enoyl-CoA hydratase; Provisional; Region: PRK05995
497978004212	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
497978004213	substrate binding site [chemical binding]; other site
497978004214	oxyanion hole (OAH) forming residues; other site
497978004215	trimer interface [polypeptide binding]; other site
497978004216	3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820
497978004217	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
497978004218	isovaleryl-CoA dehydrogenase; Region: PLN02519
497978004219	Isovaleryl-CoA dehydrogenase; Region: IVD; cd01156
497978004220	substrate binding site [chemical binding]; other site
497978004221	FAD binding site [chemical binding]; other site
497978004222	catalytic base [active]
497978004223	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
497978004224	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
497978004225	AMP-binding domain protein; Validated; Region: PRK08315
497978004226	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
497978004227	Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917
497978004228	acyl-activating enzyme (AAE) consensus motif; other site
497978004229	putative AMP binding site [chemical binding]; other site
497978004230	putative active site [active]
497978004231	putative CoA binding site [chemical binding]; other site
497978004232	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
497978004233	S-adenosylmethionine binding site [chemical binding]; other site
497978004234	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
497978004235	SGNH_hydrolase subfamily, similar to the putative arylesterase/acylhydrolase from the rumen anaerobe Prevotella bryantii XynE. The P. bryantii XynE gene is located in a xylanase gene cluster. SGNH hydrolases are a diverse family of lipases and esterases; Region: XynE_like; cd01830
497978004236	active site
497978004237	catalytic triad [active]
497978004238	oxyanion hole [active]
497978004239	Transcriptional regulator [Transcription]; Region: LysR; COG0583
497978004240	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
497978004241	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
497978004242	putative effector binding pocket; other site
497978004243	dimerization interface [polypeptide binding]; other site
497978004244	The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia.  This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775
497978004245	Competence-damaged protein; Region: CinA; pfam02464
497978004246	hydroperoxidase II; Provisional; Region: katE; PRK11249
497978004247	Clade 2 of the heme-binding enzyme catalase; Region: catalase_clade_2; cd08155
497978004248	tetramer interface [polypeptide binding]; other site
497978004249	heme binding pocket [chemical binding]; other site
497978004250	Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132
497978004251	domain interactions; other site
497978004252	short chain dehydrogenase; Provisional; Region: PRK06701
497978004253	classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355
497978004254	NAD binding site [chemical binding]; other site
497978004255	metal binding site [ion binding]; metal-binding site
497978004256	active site
497978004257	Stress-induced bacterial acidophilic repeat motif; Region: KGG; pfam10685
497978004258	SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974
497978004259	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
497978004260	Catalytic site [active]
497978004261	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
497978004262	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
497978004263	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
497978004264	putative DNA binding site [nucleotide binding]; other site
497978004265	putative Zn2+ binding site [ion binding]; other site
497978004266	AsnC family; Region: AsnC_trans_reg; pfam01037
497978004267	Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456
497978004268	Na binding site [ion binding]; other site
497978004269	Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456
497978004270	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
497978004271	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
497978004272	dimer interface [polypeptide binding]; other site
497978004273	phosphorylation site [posttranslational modification]
497978004274	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
497978004275	ATP binding site [chemical binding]; other site
497978004276	Mg2+ binding site [ion binding]; other site
497978004277	G-X-G motif; other site
497978004278	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
497978004279	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
497978004280	active site
497978004281	phosphorylation site [posttranslational modification]
497978004282	intermolecular recognition site; other site
497978004283	dimerization interface [polypeptide binding]; other site
497978004284	Response regulator receiver domain; Region: Response_reg; pfam00072
497978004285	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
497978004286	active site
497978004287	phosphorylation site [posttranslational modification]
497978004288	intermolecular recognition site; other site
497978004289	dimerization interface [polypeptide binding]; other site
497978004290	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
497978004291	DNA binding residues [nucleotide binding]
497978004292	dimerization interface [polypeptide binding]; other site
497978004293	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
497978004294	Coenzyme A binding pocket [chemical binding]; other site
497978004295	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
497978004296	dimer interface [polypeptide binding]; other site
497978004297	conserved gate region; other site
497978004298	putative PBP binding loops; other site
497978004299	ABC-ATPase subunit interface; other site
497978004300	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
497978004301	dimer interface [polypeptide binding]; other site
497978004302	conserved gate region; other site
497978004303	putative PBP binding loops; other site
497978004304	ABC-ATPase subunit interface; other site
497978004305	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
497978004306	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
497978004307	Walker A/P-loop; other site
497978004308	ATP binding site [chemical binding]; other site
497978004309	Q-loop/lid; other site
497978004310	ABC transporter signature motif; other site
497978004311	Walker B; other site
497978004312	D-loop; other site
497978004313	H-loop/switch region; other site
497978004314	Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062
497978004315	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
497978004316	substrate binding pocket [chemical binding]; other site
497978004317	membrane-bound complex binding site; other site
497978004318	hinge residues; other site
497978004319	Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062
497978004320	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
497978004321	substrate binding pocket [chemical binding]; other site
497978004322	membrane-bound complex binding site; other site
497978004323	hinge residues; other site
497978004324	Transcriptional regulator [Transcription]; Region: LysR; COG0583
497978004325	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
497978004326	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
497978004327	putative effector binding pocket; other site
497978004328	dimerization interface [polypeptide binding]; other site
497978004329	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
497978004330	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
497978004331	Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453
497978004332	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
497978004333	catalytic residue [active]
497978004334	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
497978004335	trimer interface [polypeptide binding]; other site
497978004336	active site
497978004337	substrate binding site [chemical binding]; other site
497978004338	CoA binding site [chemical binding]; other site
497978004339	Member of the Rhodanese Homology Domain superfamily, subgroup 1. This CD includes the putative rhodanese-related sulfurtransferases of several uncharacterized proteins; Region: RHOD_1; cd01522
497978004340	active site residue [active]
497978004341	short chain dehydrogenase; Provisional; Region: PRK12937
497978004342	tetrahydroxynaphthalene/trihydroxynaphthalene reductase-like, classical (c) SDRs; Region: THN_reductase-like_SDR_c; cd05362
497978004343	NADP binding site [chemical binding]; other site
497978004344	homodimer interface [polypeptide binding]; other site
497978004345	active site
497978004346	substrate binding site [chemical binding]; other site
497978004347	Transcriptional regulator [Transcription]; Region: LysR; COG0583
497978004348	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
497978004349	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472
497978004350	putative effector binding pocket; other site
497978004351	putative dimerization interface [polypeptide binding]; other site
497978004352	putative S-transferase; Provisional; Region: PRK11752
497978004353	GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048
497978004354	C-terminal domain interface [polypeptide binding]; other site
497978004355	GSH binding site (G-site) [chemical binding]; other site
497978004356	dimer interface [polypeptide binding]; other site
497978004357	C-terminal, alpha helical domain of Escherichia coli Yghu Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YghU_like; cd10292
497978004358	dimer interface [polypeptide binding]; other site
497978004359	N-terminal domain interface [polypeptide binding]; other site
497978004360	active site
497978004361	glutathione S-transferase; Provisional; Region: PRK15113
497978004362	Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of  glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570
497978004363	C-terminal domain interface [polypeptide binding]; other site
497978004364	GSH binding site (G-site) [chemical binding]; other site
497978004365	dimer interface [polypeptide binding]; other site
497978004366	C-terminal, alpha helical domain of an unknown subfamily 4 of Glutathione S-transferases; Region: GST_C_4; cd03195
497978004367	putative dimer interface [polypeptide binding]; other site
497978004368	N-terminal domain interface [polypeptide binding]; other site
497978004369	putative substrate binding pocket (H-site) [chemical binding]; other site
497978004370	Transcriptional regulator [Transcription]; Region: LysR; COG0583
497978004371	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
497978004372	The C-terminal substrate binding domain of LysR-like transcriptional regulator CidR, contains the type 2 periplasmic binding fold; Region: PBP2_CidR; cd08438
497978004373	putative dimerization interface [polypeptide binding]; other site
497978004374	LrgA family; Region: LrgA; cl00608
497978004375	Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346
497978004376	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
497978004377	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
497978004378	DNA-binding site [nucleotide binding]; DNA binding site
497978004379	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
497978004380	pyridoxal 5'-phosphate binding site [chemical binding]; other site
497978004381	homodimer interface [polypeptide binding]; other site
497978004382	catalytic residue [active]
497978004383	Transcriptional regulator [Transcription]; Region: PaiB; COG2808
497978004384	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
497978004385	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
497978004386	Major Facilitator Superfamily; Region: MFS_1; pfam07690
497978004387	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
497978004388	putative substrate translocation pore; other site
497978004389	malonate decarboxylase, alpha subunit; Region: mdcA; TIGR01110
497978004390	triphosphoribosyl-dephospho-CoA synthase; Validated; Region: PRK01237
497978004391	malonate decarboxylase subunit delta; Provisional; Region: PRK01220
497978004392	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189
497978004393	malonate decarboxylase, gamma subunit; Region: malonate_gamma; TIGR03134
497978004394	phosphoribosyl-dephospho-CoA transferase; Provisional; Region: PRK01293
497978004395	Phosphoribosyl-dephospho-CoA transferase MdcG; Region: MdcG; pfam10620
497978004396	malonate decarboxylase, epsilon subunit; Region: malonate_mdcH; TIGR03131
497978004397	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
497978004398	Malonate transporter MadL subunit; Region: MadL; cl04273
497978004399	malonate transporter, MadM subunit; Region: malonate_madM; TIGR00808
497978004400	Transcriptional regulator [Transcription]; Region: LysR; COG0583
497978004401	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
497978004402	The C-terminal substrate-binding domian of LysR-type transcriptional regulator MdcR, which involved in the malonate catabolism contains the type 2 periplasmic binding fold; Region: PBP2_MdcR; cd08416
497978004403	putative dimerization interface [polypeptide binding]; other site
497978004404	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
497978004405	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
497978004406	DNA-binding site [nucleotide binding]; DNA binding site
497978004407	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
497978004408	pyridoxal 5'-phosphate binding site [chemical binding]; other site
497978004409	homodimer interface [polypeptide binding]; other site
497978004410	catalytic residue [active]
497978004411	Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322
497978004412	cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219
497978004413	Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654
497978004414	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
497978004415	sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022
497978004416	active site
497978004417	FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860
497978004418	nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095
497978004419	active site
497978004420	non-prolyl cis peptide bond; other site
497978004421	Sugar (and other) transporter; Region: Sugar_tr; pfam00083
497978004422	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
497978004423	putative substrate translocation pore; other site
497978004424	taurine ABC transporter, periplasmic binding protein; Region: taurine_ABC_bnd; TIGR01729
497978004425	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
497978004426	substrate binding pocket [chemical binding]; other site
497978004427	membrane-bound complex binding site; other site
497978004428	hinge residues; other site
497978004429	taurine transporter ATP-binding subunit; Provisional; Region: tauB; PRK11248
497978004430	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
497978004431	Walker A/P-loop; other site
497978004432	ATP binding site [chemical binding]; other site
497978004433	Q-loop/lid; other site
497978004434	ABC transporter signature motif; other site
497978004435	Walker B; other site
497978004436	D-loop; other site
497978004437	H-loop/switch region; other site
497978004438	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
497978004439	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
497978004440	dimer interface [polypeptide binding]; other site
497978004441	conserved gate region; other site
497978004442	putative PBP binding loops; other site
497978004443	ABC-ATPase subunit interface; other site
497978004444	taurine dioxygenase; Reviewed; Region: tauD; PRK09553
497978004445	Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175
497978004446	active site
497978004447	iron coordination sites [ion binding]; other site
497978004448	substrate binding pocket [chemical binding]; other site
497978004449	Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518
497978004450	uncharacterized nucleobase-cation-symport-1 (NCS1) transporter subfamily; solute-binding domain; Region: SLC-NCS1sbd_u1; cd11555
497978004451	Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133
497978004452	Na binding site [ion binding]; other site
497978004453	putative substrate binding site [chemical binding]; other site
497978004454	Transcriptional regulators [Transcription]; Region: GntR; COG1802
497978004455	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
497978004456	DNA-binding site [nucleotide binding]; DNA binding site
497978004457	FCD domain; Region: FCD; pfam07729
497978004458	Transcriptional regulator [Transcription]; Region: LysR; COG0583
497978004459	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
497978004460	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
497978004461	putative effector binding pocket; other site
497978004462	dimerization interface [polypeptide binding]; other site
497978004463	YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012
497978004464	Isochorismatase family; Region: Isochorismatase; pfam00857
497978004465	catalytic triad [active]
497978004466	dimer interface [polypeptide binding]; other site
497978004467	conserved cis-peptide bond; other site
497978004468	Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574
497978004469	YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300
497978004470	active site
497978004471	Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034
497978004472	ArsC family; Region: ArsC; pfam03960
497978004473	catalytic residues [active]
497978004474	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
497978004475	dimerization interface [polypeptide binding]; other site
497978004476	putative DNA binding site [nucleotide binding]; other site
497978004477	putative Zn2+ binding site [ion binding]; other site
497978004478	Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798
497978004479	arsenical-resistance protein; Region: acr3; TIGR00832
497978004480	Transcriptional regulator [Transcription]; Region: LysR; COG0583
497978004481	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
497978004482	The C-terminal substrate binding domain of LysR-type transcrptional regulator BudR, which is responsible for activation of the expression of the butanediol operon genes; contains the type 2 periplasmic binding fold; Region: PBP2_BudR; cd08451
497978004483	putative dimerization interface [polypeptide binding]; other site
497978004484	putative substrate binding pocket [chemical binding]; other site
497978004485	Chromate transporter; Region: Chromate_transp; pfam02417
497978004486	Chromate transporter; Region: Chromate_transp; pfam02417
497978004487	alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317
497978004488	Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974
497978004489	catalytic residue [active]
497978004490	TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026
497978004491	catalytic residues [active]
497978004492	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
497978004493	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
497978004494	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
497978004495	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
497978004496	TPR motif; other site
497978004497	binding surface
497978004498	serine O-acetyltransferase; Region: cysE; TIGR01172
497978004499	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
497978004500	trimer interface [polypeptide binding]; other site
497978004501	active site
497978004502	substrate binding site [chemical binding]; other site
497978004503	CoA binding site [chemical binding]; other site
497978004504	rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565
497978004505	SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307
497978004506	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433
497978004507	DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673
497978004508	putative active site [active]
497978004509	putative PHP Thumb interface [polypeptide binding]; other site
497978004510	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
497978004511	generic binding surface I; other site
497978004512	generic binding surface II; other site
497978004513	Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964
497978004514	active site
497978004515	homodimer interface [polypeptide binding]; other site
497978004516	homotetramer interface [polypeptide binding]; other site
497978004517	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
497978004518	Sodium:dicarboxylate symporter family; Region: SDF; cl00573
497978004519	aminotransferase AlaT; Validated; Region: PRK09265
497978004520	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
497978004521	pyridoxal 5'-phosphate binding site [chemical binding]; other site
497978004522	homodimer interface [polypeptide binding]; other site
497978004523	catalytic residue [active]
497978004524	methionine sulfoxide reductase B; Provisional; Region: PRK00222
497978004525	SelR domain; Region: SelR; pfam01641
497978004526	Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340
497978004527	catalytic residues [active]
497978004528	dimer interface [polypeptide binding]; other site
497978004529	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
497978004530	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
497978004531	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
497978004532	LysE type translocator; Region: LysE; cl00565
497978004533	succinyldiaminopimelate transaminase; Provisional; Region: PRK09147
497978004534	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
497978004535	pyridoxal 5'-phosphate binding site [chemical binding]; other site
497978004536	homodimer interface [polypeptide binding]; other site
497978004537	catalytic residue [active]
497978004538	PII uridylyl-transferase; Provisional; Region: glnD; PRK00275
497978004539	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
497978004540	metal binding triad; other site
497978004541	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
497978004542	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
497978004543	Zn2+ binding site [ion binding]; other site
497978004544	Mg2+ binding site [ion binding]; other site
497978004545	ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900
497978004546	C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899
497978004547	phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288
497978004548	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
497978004549	ATP-grasp domain; Region: ATP-grasp; pfam02222
497978004550	5-carboxymethyl-2-hydroxymuconate isomerase (CHMI) is a trimeric enzyme catalyzing the isomerization of the unsaturated ketone 5-(carboxymethyl)-2-hydroxymuconate to 5-(carboxymethyl)-2-oxo-3-hexene-1,6-dionate. This is one step in the...; Region: CHMI; cl01268
497978004551	trimer interface [polypeptide binding]; other site
497978004552	putative substrate binding pocket [chemical binding]; other site
497978004553	4-Oxalocrotonate Tautomerase:  Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235
497978004554	active site 1 [active]
497978004555	dimer interface [polypeptide binding]; other site
497978004556	hexamer interface [polypeptide binding]; other site
497978004557	active site 2 [active]
497978004558	putative L-valine exporter; Provisional; Region: PRK10408
497978004559	AzlC protein; Region: AzlC; cl00570
497978004560	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
497978004561	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
497978004562	ligand binding site [chemical binding]; other site
497978004563	flexible hinge region; other site
497978004564	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
497978004565	putative switch regulator; other site
497978004566	non-specific DNA interactions [nucleotide binding]; other site
497978004567	DNA binding site [nucleotide binding]
497978004568	sequence specific DNA binding site [nucleotide binding]; other site
497978004569	putative cAMP binding site [chemical binding]; other site
497978004570	Predicted membrane protein [Function unknown]; Region: COG4539
497978004571	GTP-binding protein YchF; Reviewed; Region: PRK09601
497978004572	YchF GTPase; Region: YchF; cd01900
497978004573	G1 box; other site
497978004574	GTP/Mg2+ binding site [chemical binding]; other site
497978004575	Switch I region; other site
497978004576	G2 box; other site
497978004577	Switch II region; other site
497978004578	G3 box; other site
497978004579	G4 box; other site
497978004580	G5 box; other site
497978004581	TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867
497978004582	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
497978004583	dimer interface [polypeptide binding]; other site
497978004584	conserved gate region; other site
497978004585	ABC-ATPase subunit interface; other site
497978004586	DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153
497978004587	ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258
497978004588	Walker A/P-loop; other site
497978004589	ATP binding site [chemical binding]; other site
497978004590	Q-loop/lid; other site
497978004591	ABC transporter signature motif; other site
497978004592	Walker B; other site
497978004593	D-loop; other site
497978004594	H-loop/switch region; other site
497978004595	This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930
497978004596	NLPA lipoprotein; Region: Lipoprotein_9; pfam03180
497978004597	NLPA lipoprotein; Region: Lipoprotein_9; pfam03180
497978004598	FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860
497978004599	nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095
497978004600	active site
497978004601	non-prolyl cis peptide bond; other site
497978004602	sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022
497978004603	Dibenzothiophene (DBT) desulfurization enzyme C; Region: DszC; cd01163
497978004604	Flavin binding site [chemical binding]; other site
497978004605	sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022
497978004606	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
497978004607	active site
497978004608	Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of  glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570
497978004609	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
497978004610	C-terminal domain interface [polypeptide binding]; other site
497978004611	GSH binding site (G-site) [chemical binding]; other site
497978004612	dimer interface [polypeptide binding]; other site
497978004613	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776
497978004614	N-terminal domain interface [polypeptide binding]; other site
497978004615	glutamate and aspartate transporter subunit; Provisional; Region: PRK10797
497978004616	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
497978004617	substrate binding pocket [chemical binding]; other site
497978004618	membrane-bound complex binding site; other site
497978004619	hinge residues; other site
497978004620	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
497978004621	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
497978004622	dimer interface [polypeptide binding]; other site
497978004623	conserved gate region; other site
497978004624	putative PBP binding loops; other site
497978004625	ABC-ATPase subunit interface; other site
497978004626	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
497978004627	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
497978004628	dimer interface [polypeptide binding]; other site
497978004629	conserved gate region; other site
497978004630	putative PBP binding loops; other site
497978004631	ABC-ATPase subunit interface; other site
497978004632	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
497978004633	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
497978004634	Walker A/P-loop; other site
497978004635	ATP binding site [chemical binding]; other site
497978004636	Q-loop/lid; other site
497978004637	ABC transporter signature motif; other site
497978004638	Walker B; other site
497978004639	D-loop; other site
497978004640	H-loop/switch region; other site
497978004641	DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563
497978004642	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
497978004643	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
497978004644	putative DNA binding site [nucleotide binding]; other site
497978004645	putative Zn2+ binding site [ion binding]; other site
497978004646	AsnC family; Region: AsnC_trans_reg; pfam01037
497978004647	hypothetical protein; Validated; Region: PRK00110
497978004648	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown ABO13168; Region: LPLAT_ABO13168-like; cd07988
497978004649	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
497978004650	putative acyl-acceptor binding pocket; other site
497978004651	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
497978004652	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
497978004653	Domain of unknown function (DUF4102); Region: DUF4102; pfam13356
497978004654	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
497978004655	active site
497978004656	catalytic residues [active]
497978004657	Int/Topo IB signature motif; other site
497978004658	DNA binding site [nucleotide binding]
497978004659	Transcriptional regulator [Transcription]; Region: LysR; COG0583
497978004660	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
497978004661	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
497978004662	dimerization interface [polypeptide binding]; other site
497978004663	Predicted membrane protein [Function unknown]; Region: COG4125
497978004664	Bacterial Transmembrane Pair family; Region: BTP; pfam05232
497978004665	Bacterial Transmembrane Pair family; Region: BTP; pfam05232
497978004666	Purine-cytosine permease and related proteins [Nucleotide transport and metabolism]; Region: CodB; COG1457
497978004667	Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133
497978004668	Na binding site [ion binding]; other site
497978004669	EamA-like transporter family; Region: EamA; pfam00892
497978004670	Transcriptional regulator [Transcription]; Region: LysR; COG0583
497978004671	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
497978004672	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
497978004673	dimerization interface [polypeptide binding]; other site
497978004674	putative major fimbrial protein SthE; Provisional; Region: PRK15292
497978004675	P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539
497978004676	P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188
497978004677	PapC N-terminal domain; Region: PapC_N; pfam13954
497978004678	Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577
497978004679	PapC C-terminal domain; Region: PapC_C; pfam13953
497978004680	P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121
497978004681	Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345
497978004682	Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753
497978004683	P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539
497978004684	biotin synthase; Provisional; Region: PRK15108
497978004685	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
497978004686	FeS/SAM binding site; other site
497978004687	Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876
497978004688	epoxyqueuosine reductase; Region: TIGR00276
497978004689	Domain of unknown function (DUF1730); Region: DUF1730; pfam08331
497978004690	putative carbohydrate kinase; Provisional; Region: PRK10565
497978004691	YjeF-related protein N-terminus; Region: YjeF_N; pfam03853
497978004692	B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171
497978004693	putative substrate binding site [chemical binding]; other site
497978004694	putative ATP binding site [chemical binding]; other site
497978004695	Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529
497978004696	active site
497978004697	putative DNA-binding cleft [nucleotide binding]; other site
497978004698	dimer interface [polypeptide binding]; other site
497978004699	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
497978004700	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
497978004701	non-specific DNA binding site [nucleotide binding]; other site
497978004702	salt bridge; other site
497978004703	sequence-specific DNA binding site [nucleotide binding]; other site
497978004704	Cupin domain; Region: Cupin_2; cl17218
497978004705	Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247
497978004706	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
497978004707	Beta-lactamase class D [Defense mechanisms]; Region: COG2602
497978004708	FxsA cytoplasmic membrane protein; Region: FxsA; pfam04186
497978004709	N2,N2-dimethylguanosine tRNA methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TRM1; COG1867
497978004710	S-adenosylmethionine synthetase; Validated; Region: PRK05250
497978004711	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
497978004712	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
497978004713	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
497978004714	transketolase; Reviewed; Region: PRK12753
497978004715	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
497978004716	TPP-binding site [chemical binding]; other site
497978004717	dimer interface [polypeptide binding]; other site
497978004718	ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192
497978004719	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
497978004720	PYR/PP interface [polypeptide binding]; other site
497978004721	dimer interface [polypeptide binding]; other site
497978004722	TPP binding site [chemical binding]; other site
497978004723	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
497978004724	OsmC-like protein; Region: OsmC; pfam02566
497978004725	Uncharacterized conserved protein [Function unknown]; Region: COG2353
497978004726	Lecithin retinol acyltransferase; Region: LRAT; pfam04970
497978004727	Predicted periplasmic protein [Function unknown]; Region: COG3698
497978004728	Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992
497978004729	tRNA (uracil-5-)-methyltransferase; Validated; Region: PRK05031
497978004730	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
497978004731	S-adenosylmethionine binding site [chemical binding]; other site
497978004732	Uncharacterized protein family (UPF0157); Region: UPF0157; cl00987
497978004733	bifunctional proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: PRK11905
497978004734	Proline dehydrogenase [Amino acid transport and metabolism]; Region: PutA; COG0506
497978004735	Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125
497978004736	Glutamate binding site [chemical binding]; other site
497978004737	NAD binding site [chemical binding]; other site
497978004738	catalytic residues [active]
497978004739	leucine-responsive transcriptional regulator; Provisional; Region: PRK11169
497978004740	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
497978004741	dimerization interface [polypeptide binding]; other site
497978004742	putative DNA binding site [nucleotide binding]; other site
497978004743	putative Zn2+ binding site [ion binding]; other site
497978004744	AsnC family; Region: AsnC_trans_reg; pfam01037
497978004745	Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475
497978004746	Na binding site [ion binding]; other site
497978004747	NAD-dependent deacetylase; Provisional; Region: PRK00481
497978004748	SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412
497978004749	NAD+ binding site [chemical binding]; other site
497978004750	substrate binding site [chemical binding]; other site
497978004751	Zn binding site [ion binding]; other site
497978004752	Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848
497978004753	lipoyl attachment site [posttranslational modification]; other site
497978004754	Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625
497978004755	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
497978004756	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
497978004757	YdeM is a Bacillus subtilis protein that belongs to a family of prokaryotic proteins of unkown function.  YdeM has sequence similarity to the hot-dog fold of (R)-specific enoyl-CoA hydratase.   Other enzymes with this fold include the peroxisomal...; Region: YdeM; cd03454
497978004758	putative active site [active]
497978004759	putative catalytic site [active]
497978004760	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
497978004761	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
497978004762	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
497978004763	Walker A/P-loop; other site
497978004764	ATP binding site [chemical binding]; other site
497978004765	Q-loop/lid; other site
497978004766	ABC transporter signature motif; other site
497978004767	Walker B; other site
497978004768	D-loop; other site
497978004769	H-loop/switch region; other site
497978004770	Uncharacterized protein conserved in bacteria (DUF2058); Region: DUF2058; pfam09831
497978004771	Protein of unknown function (DUF1275); Region: DUF1275; pfam06912
497978004772	serine/threonine transporter SstT; Provisional; Region: PRK13628
497978004773	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
497978004774	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
497978004775	dimerization interface [polypeptide binding]; other site
497978004776	putative DNA binding site [nucleotide binding]; other site
497978004777	putative Zn2+ binding site [ion binding]; other site
497978004778	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
497978004779	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
497978004780	Cupin superfamily protein; Region: Cupin_4; pfam08007
497978004781	Cupin-like domain; Region: Cupin_8; pfam13621
497978004782	Maf-like protein; Region: Maf; pfam02545
497978004783	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
497978004784	active site
497978004785	dimer interface [polypeptide binding]; other site
497978004786	Uncharacterized protein conserved in bacteria (DUF2237); Region: DUF2237; pfam09996
497978004787	phosphoglycerate kinase; Provisional; Region: pgk; PRK00073
497978004788	Phosphoglycerate kinase; Region: PGK; pfam00162
497978004789	substrate binding site [chemical binding]; other site
497978004790	hinge regions; other site
497978004791	ADP binding site [chemical binding]; other site
497978004792	catalytic site [active]
497978004793	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947
497978004794	fructose-bisphosphate aldolase; Provisional; Region: PRK09197
497978004795	intersubunit interface [polypeptide binding]; other site
497978004796	active site
497978004797	zinc binding site [ion binding]; other site
497978004798	Na+ binding site [ion binding]; other site
497978004799	peptidyl-prolyl cis-trans isomerase SurA; Provisional; Region: PRK10770
497978004800	SurA N-terminal domain; Region: SurA_N; pfam09312
497978004801	PPIC-type PPIASE domain; Region: Rotamase_2; cl08278
497978004802	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
497978004803	Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452
497978004804	OstA-like protein; Region: OstA; cl00844
497978004805	Organic solvent tolerance protein; Region: OstA_C; pfam04453
497978004806	Predicted phosphotransferase related to Ser/Thr protein kinases [General function prediction only]; Region: COG3178
497978004807	Phosphotransferase enzyme family; Region: APH; pfam01636
497978004808	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
497978004809	NTP_transferase_like_1 is a member of the nucleotidyl transferase family; Region: NTP_transferase_like_1; cd06422
497978004810	Substrate binding site; other site
497978004811	metal-binding site
497978004812	16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107
497978004813	rRNA small subunit methyltransferase G; Region: GidB; pfam02527
497978004814	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
497978004815	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
497978004816	P-loop; other site
497978004817	Magnesium ion binding site [ion binding]; other site
497978004818	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
497978004819	Magnesium ion binding site [ion binding]; other site
497978004820	ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180
497978004821	ParB-like nuclease domain; Region: ParB; smart00470
497978004822	Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811
497978004823	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
497978004824	Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472
497978004825	lipid A export permease/ATP-binding protein MsbA; Region: MsbA_lipidA; TIGR02203
497978004826	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
497978004827	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
497978004828	Walker A/P-loop; other site
497978004829	ATP binding site [chemical binding]; other site
497978004830	Q-loop/lid; other site
497978004831	ABC transporter signature motif; other site
497978004832	Walker B; other site
497978004833	D-loop; other site
497978004834	H-loop/switch region; other site
497978004835	Tetraacyldisaccharide-1-P 4'-kinase [Cell envelope biogenesis, outer membrane]; Region: LpxK; COG1663
497978004836	Tetraacyldisaccharide-1-P 4'-kinase; Region: LpxK; pfam02606
497978004837	3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450
497978004838	CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517
497978004839	Ligand binding site; other site
497978004840	oligomer interface; other site
497978004841	DNA polymerase III subunit delta'; Validated; Region: PRK05707
497978004842	PilZ domain; Region: PilZ; cl01260
497978004843	Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099
497978004844	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
497978004845	active site
497978004846	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
497978004847	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
497978004848	Type II secretion system (T2SS), protein I; Region: T2SI; pfam02501
497978004849	type II secretion system protein J; Region: gspJ; TIGR01711
497978004850	prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532
497978004851	Type II secretion system (T2SS), protein J; Region: T2SJ; pfam11612
497978004852	Type II secretion system (T2SS), protein K; Region: T2SK; pfam03934
497978004853	6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242
497978004854	Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027
497978004855	ligand binding site [chemical binding]; other site
497978004856	active site
497978004857	UGI interface [polypeptide binding]; other site
497978004858	catalytic site [active]
497978004859	3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617
497978004860	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
497978004861	substrate binding site [chemical binding]; other site
497978004862	oxyanion hole (OAH) forming residues; other site
497978004863	trimer interface [polypeptide binding]; other site
497978004864	2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766
497978004865	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
497978004866	nucleoside/Zn binding site; other site
497978004867	dimer interface [polypeptide binding]; other site
497978004868	catalytic motif [active]
497978004869	Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821
497978004870	putative hydrophobic ligand binding site [chemical binding]; other site
497978004871	protein interface [polypeptide binding]; other site
497978004872	gate; other site
497978004873	cytidylate kinase; Provisional; Region: cmk; PRK00023
497978004874	Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020
497978004875	CMP-binding site; other site
497978004876	The sites determining sugar specificity; other site
497978004877	30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299
497978004878	S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687
497978004879	RNA binding site [nucleotide binding]; other site
497978004880	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
497978004881	RNA binding site [nucleotide binding]; other site
497978004882	S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688
497978004883	RNA binding site [nucleotide binding]; other site
497978004884	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
497978004885	RNA binding site [nucleotide binding]; other site
497978004886	S1_RPS1_repeat_ec5: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec5; cd05690
497978004887	RNA binding site [nucleotide binding]; other site
497978004888	S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec6; cd05691
497978004889	RNA binding site [nucleotide binding]; other site
497978004890	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
497978004891	IHF dimer interface [polypeptide binding]; other site
497978004892	IHF - DNA interface [nucleotide binding]; other site
497978004893	Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725
497978004894	active site
497978004895	dimer interface [polypeptide binding]; other site
497978004896	Membrane protein of unknown function (DUF340); Region: DUF340; cl01028
497978004897	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
497978004898	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
497978004899	Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625
497978004900	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
497978004901	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
497978004902	Predicted ATPase [General function prediction only]; Region: COG1485
497978004903	malate synthase G; Provisional; Region: PRK02999
497978004904	active site
497978004905	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
497978004906	Coenzyme A binding pocket [chemical binding]; other site
497978004907	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
497978004908	Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472
497978004909	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
497978004910	Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472
497978004911	Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811
497978004912	Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810
497978004913	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
497978004914	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
497978004915	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
497978004916	N-terminal plug; other site
497978004917	ligand-binding site [chemical binding]; other site
497978004918	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_18; cd08505
497978004919	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
497978004920	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_18; cd08505
497978004921	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
497978004922	Peptidase M3 Thimet oligopeptidase (TOP) also includes neurolysin; Region: M3A_TOP; cd06455
497978004923	Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339
497978004924	active site
497978004925	Zn binding site [ion binding]; other site
497978004926	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
497978004927	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
497978004928	dimer interface [polypeptide binding]; other site
497978004929	conserved gate region; other site
497978004930	putative PBP binding loops; other site
497978004931	ABC-ATPase subunit interface; other site
497978004932	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
497978004933	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
497978004934	dimer interface [polypeptide binding]; other site
497978004935	conserved gate region; other site
497978004936	putative PBP binding loops; other site
497978004937	ABC-ATPase subunit interface; other site
497978004938	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
497978004939	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
497978004940	Walker A/P-loop; other site
497978004941	ATP binding site [chemical binding]; other site
497978004942	Q-loop/lid; other site
497978004943	ABC transporter signature motif; other site
497978004944	Walker B; other site
497978004945	D-loop; other site
497978004946	H-loop/switch region; other site
497978004947	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
497978004948	Walker A/P-loop; other site
497978004949	ATP binding site [chemical binding]; other site
497978004950	Q-loop/lid; other site
497978004951	ABC transporter signature motif; other site
497978004952	Walker B; other site
497978004953	D-loop; other site
497978004954	H-loop/switch region; other site
497978004955	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
497978004956	Uncharacterized ACR, COG2135; Region: DUF159; pfam02586
497978004957	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
497978004958	CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638
497978004959	active site
497978004960	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
497978004961	catalytic core [active]
497978004962	30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239
497978004963	CC3(TIP30)-like, atypical (a) SDRs; Region: CC3_like_SDR_a; cd05250
497978004964	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
497978004965	NAD binding site [chemical binding]; other site
497978004966	active site
497978004967	ribonuclease activity regulator protein RraA; Provisional; Region: PRK09372
497978004968	GST_N family, 2 repeats of the N-terminal domain of soluble GSTs (2 GST_N) subfamily; composed of uncharacterized proteins. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a...; Region: GST_N_2GST_N; cd03041
497978004969	putative C-terminal domain interface [polypeptide binding]; other site
497978004970	putative GSH binding site (G-site) [chemical binding]; other site
497978004971	putative dimer interface [polypeptide binding]; other site
497978004972	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
497978004973	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
497978004974	Dyp-type peroxidase family; Region: Dyp_perox; cl01067
497978004975	Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197
497978004976	CarD-like/TRCF domain; Region: CarD_TRCF; smart01058
497978004977	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
497978004978	ATP binding site [chemical binding]; other site
497978004979	putative Mg++ binding site [ion binding]; other site
497978004980	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
497978004981	nucleotide binding region [chemical binding]; other site
497978004982	ATP-binding site [chemical binding]; other site
497978004983	This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982
497978004984	HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228
497978004985	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
497978004986	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
497978004987	catalytic loop [active]
497978004988	iron binding site [ion binding]; other site
497978004989	chaperone protein HscA; Provisional; Region: hscA; PRK05183
497978004990	Nucleotide-binding domain of HscA and similar proteins; Region: HscA_like_NBD; cd10236
497978004991	nucleotide binding site [chemical binding]; other site
497978004992	putative NEF/HSP70 interaction site [polypeptide binding]; other site
497978004993	SBD interface [polypeptide binding]; other site
497978004994	co-chaperone HscB; Provisional; Region: hscB; PRK05014
497978004995	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
497978004996	HSP70 interaction site [polypeptide binding]; other site
497978004997	HSCB C-terminal oligomerisation domain; Region: HSCB_C; pfam07743
497978004998	Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400
497978004999	NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822
497978005000	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664
497978005001	trimerization site [polypeptide binding]; other site
497978005002	active site
497978005003	cysteine desulfurase; Provisional; Region: PRK14012
497978005004	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
497978005005	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
497978005006	catalytic residue [active]
497978005007	Transcriptional regulator; Region: Rrf2; cl17282
497978005008	Rrf2 family protein; Region: rrf2_super; TIGR00738
497978005009	Poly(hydroxyalcanoate) granule associated protein (phasin); Region: Phasin; pfam05597
497978005010	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
497978005011	IHF dimer interface [polypeptide binding]; other site
497978005012	IHF - DNA interface [nucleotide binding]; other site
497978005013	periplasmic folding chaperone; Provisional; Region: PRK10788
497978005014	SurA N-terminal domain; Region: SurA_N_3; cl07813
497978005015	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
497978005016	Cupin; Region: Cupin_6; pfam12852
497978005017	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
497978005018	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
497978005019	Alkane hydroxylase is a bacterial, integral-membrane di-iron enzyme that shares a requirement for iron and oxygen for activity similar to that of the non-heme integral-membrane acyl coenzyme A (CoA) desaturases and acyl lipid desaturases. The alk genes...; Region: Alkane-hydroxylase; cd03512
497978005020	Fatty acid desaturase; Region: FA_desaturase; pfam00487
497978005021	Di-iron ligands [ion binding]; other site
497978005022	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
497978005023	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
497978005024	active site
497978005025	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
497978005026	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
497978005027	active site
497978005028	Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661
497978005029	ABC1 family; Region: ABC1; cl17513
497978005030	This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002
497978005031	putative deacylase active site [active]
497978005032	Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264
497978005033	IucA / IucC family; Region: IucA_IucC; pfam04183
497978005034	Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276
497978005035	Lysine/ornithine N-monooxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: IucD; COG3486
497978005036	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
497978005037	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
497978005038	Major Facilitator Superfamily; Region: MFS_1; pfam07690
497978005039	putative substrate translocation pore; other site
497978005040	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
497978005041	Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264
497978005042	IucA / IucC family; Region: IucA_IucC; pfam04183
497978005043	Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276
497978005044	Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264
497978005045	IucA / IucC family; Region: IucA_IucC; pfam04183
497978005046	Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276
497978005047	FhuF 2Fe-2S C-terminal domain; Region: FhuF_C; pfam11575
497978005048	Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480
497978005049	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
497978005050	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
497978005051	N-terminal plug; other site
497978005052	ligand-binding site [chemical binding]; other site
497978005053	Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182
497978005054	PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703
497978005055	Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523
497978005056	Siderophore biosynthesis protein domain; Region: AlcB; smart01006
497978005057	beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009
497978005058	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
497978005059	motif II; other site
497978005060	Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125
497978005061	2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563
497978005062	Cellular and retroviral pepsin-like aspartate proteases; Region: pepsin_retropepsin_like; cl11403
497978005063	Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544
497978005064	homotrimer interface [polypeptide binding]; other site
497978005065	Walker A motif; other site
497978005066	GTP binding site [chemical binding]; other site
497978005067	Walker B motif; other site
497978005068	Phosphoribosyltransferase; Region: DBI_PRT; pfam02277
497978005069	Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439
497978005070	putative dimer interface [polypeptide binding]; other site
497978005071	active site pocket [active]
497978005072	putative cataytic base [active]
497978005073	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
497978005074	catalytic core [active]
497978005075	Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061
497978005076	cobalamin synthase; Reviewed; Region: cobS; PRK00235
497978005077	phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261
497978005078	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
497978005079	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
497978005080	Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182
497978005081	PepSY-associated TM helix; Region: PepSY_TM_3; pfam13706
497978005082	PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703
497978005083	Outer membrane receptor for ferric coprogen and ferric-rhodotorulic acid [Inorganic ion transport and metabolism]; Region: FhuE; COG4773
497978005084	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
497978005085	N-terminal plug; other site
497978005086	ligand-binding site [chemical binding]; other site
497978005087	lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025
497978005088	ipid-A-disaccharide synthase; Provisional; Region: PRK14089
497978005089	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
497978005090	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
497978005091	Domain of unknown function (DUF1956); Region: DUF1956; pfam09209
497978005092	putative efflux pump membrane fusion protein; Provisional; Region: PRK03598
497978005093	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
497978005094	HlyD family secretion protein; Region: HlyD_3; pfam13437
497978005095	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
497978005096	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
497978005097	Walker A/P-loop; other site
497978005098	ATP binding site [chemical binding]; other site
497978005099	Q-loop/lid; other site
497978005100	ABC transporter signature motif; other site
497978005101	Walker B; other site
497978005102	D-loop; other site
497978005103	H-loop/switch region; other site
497978005104	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
497978005105	ATP-binding cassette domain of the lipid transporters, subfamily A; Region: ABC_subfamily_A; cd03263
497978005106	Walker A/P-loop; other site
497978005107	ATP binding site [chemical binding]; other site
497978005108	Q-loop/lid; other site
497978005109	ABC transporter signature motif; other site
497978005110	Walker B; other site
497978005111	D-loop; other site
497978005112	H-loop/switch region; other site
497978005113	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
497978005114	ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679
497978005115	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
497978005116	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
497978005117	Protein of unknown function (DUF2797); Region: DUF2797; pfam10977
497978005118	Bacterial protein of unknown function (DUF937); Region: DUF937; cl01528
497978005119	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
497978005120	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
497978005121	eyelet of channel; other site
497978005122	trimer interface [polypeptide binding]; other site
497978005123	HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277
497978005124	HIT family signature motif; other site
497978005125	catalytic residue [active]
497978005126	Uncharacterized conserved protein [Function unknown]; Region: COG3791
497978005127	TonB C terminal; Region: TonB_2; pfam13103
497978005128	Methyltransferase domain; Region: Methyltransf_23; pfam13489
497978005129	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
497978005130	S-adenosylmethionine binding site [chemical binding]; other site
497978005131	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
497978005132	O-succinylhomoserine sulfhydrylase; Validated; Region: PRK08133
497978005133	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
497978005134	homodimer interface [polypeptide binding]; other site
497978005135	substrate-cofactor binding pocket; other site
497978005136	pyridoxal 5'-phosphate binding site [chemical binding]; other site
497978005137	catalytic residue [active]
497978005138	Transposase; Region: HTH_Tnp_1; cl17663
497978005139	IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717
497978005140	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
497978005141	Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007
497978005142	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
497978005143	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005
497978005144	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
497978005145	IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817
497978005146	hypothetical protein; Validated; Region: PRK00153
497978005147	recombination protein RecR; Reviewed; Region: recR; PRK00076
497978005148	RecR protein; Region: RecR; pfam02132
497978005149	TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR.  RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025
497978005150	putative active site [active]
497978005151	putative metal-binding site [ion binding]; other site
497978005152	tetramer interface [polypeptide binding]; other site
497978005153	Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349
497978005154	DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142
497978005155	catalytic site [active]
497978005156	putative active site [active]
497978005157	putative substrate binding site [chemical binding]; other site
497978005158	HRDC domain; Region: HRDC; pfam00570
497978005159	YcgL domain; Region: YcgL; pfam05166
497978005160	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
497978005161	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
497978005162	Walker A motif; other site
497978005163	ATP binding site [chemical binding]; other site
497978005164	Walker B motif; other site
497978005165	arginine finger; other site
497978005166	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3825
497978005167	tryptophan synthase, beta subunit; Region: trpB; TIGR00263
497978005168	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
497978005169	pyridoxal 5'-phosphate binding site [chemical binding]; other site
497978005170	catalytic residue [active]
497978005171	HemK family putative methylases; Region: hemK_fam; TIGR00536
497978005172	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
497978005173	S-adenosylmethionine binding site [chemical binding]; other site
497978005174	Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082
497978005175	Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304
497978005176	Tetramer interface [polypeptide binding]; other site
497978005177	active site
497978005178	FMN-binding site [chemical binding]; other site
497978005179	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
497978005180	metal binding site [ion binding]; metal-binding site
497978005181	active site
497978005182	I-site; other site
497978005183	TENA/THI-4/PQQC family; Region: TENA_THI-4; cl15243
497978005184	Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862
497978005185	lipoyl synthase; Provisional; Region: PRK12928
497978005186	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
497978005187	FeS/SAM binding site; other site
497978005188	pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182
497978005189	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
497978005190	tetramer interface [polypeptide binding]; other site
497978005191	TPP-binding site [chemical binding]; other site
497978005192	heterodimer interface [polypeptide binding]; other site
497978005193	phosphorylation loop region [posttranslational modification]
497978005194	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022
497978005195	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
497978005196	alpha subunit interface [polypeptide binding]; other site
497978005197	TPP binding site [chemical binding]; other site
497978005198	heterodimer interface [polypeptide binding]; other site
497978005199	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
497978005200	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
497978005201	pyruvate dehydrogenase complex dihydrolipoamide acetyltransferase, long form; Region: PDHac_trf_mito; TIGR01349
497978005202	E3 interaction surface; other site
497978005203	lipoyl attachment site [posttranslational modification]; other site
497978005204	e3 binding domain; Region: E3_binding; pfam02817
497978005205	e3 binding domain; Region: E3_binding; pfam02817
497978005206	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
497978005207	dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416
497978005208	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
497978005209	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
497978005210	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
497978005211	meso-2,3-butanediol dehydrogenase-like, classical (c) SDRs; Region: meso-BDH-like_SDR_c; cd05366
497978005212	acetoin reductases; Region: 23BDH; TIGR02415
497978005213	NAD binding site [chemical binding]; other site
497978005214	homotetramer interface [polypeptide binding]; other site
497978005215	homodimer interface [polypeptide binding]; other site
497978005216	active site
497978005217	substrate binding site [chemical binding]; other site
497978005218	(2R,3R)-2,3-butanediol dehydrogenase; Region: butanediol_DH_like; cd08233
497978005219	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
497978005220	putative NAD(P) binding site [chemical binding]; other site
497978005221	catalytic Zn binding site [ion binding]; other site
497978005222	Bestrophin, RFP-TM, chloride channel; Region: Bestrophin; pfam01062
497978005223	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
497978005224	psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974
497978005225	Walker A motif; other site
497978005226	ATP binding site [chemical binding]; other site
497978005227	Walker B motif; other site
497978005228	arginine finger; other site
497978005229	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
497978005230	Putative phosphatase (DUF442); Region: DUF442; cl17385
497978005231	Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446
497978005232	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
497978005233	Homoserine dehydrogenase [Amino acid transport and metabolism]; Region: ThrA; COG0460
497978005234	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
497978005235	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
497978005236	EamA-like transporter family; Region: EamA; pfam00892
497978005237	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
497978005238	EamA-like transporter family; Region: EamA; pfam00892
497978005239	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
497978005240	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
497978005241	HTH-like domain; Region: HTH_21; pfam13276
497978005242	DDE domain; Region: DDE_Tnp_IS240; pfam13610
497978005243	Integrase core domain; Region: rve; pfam00665
497978005244	Integrase core domain; Region: rve_3; pfam13683
497978005245	Transposase; Region: HTH_Tnp_1; cl17663
497978005246	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
497978005247	Predicted transcriptional regulators [Transcription]; Region: COG1733
497978005248	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
497978005249	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
497978005250	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
497978005251	Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059
497978005252	chromate transporter, chromate ion transporter (CHR) family; Region: 2A51; TIGR00937
497978005253	Chromate transporter; Region: Chromate_transp; pfam02417
497978005254	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
497978005255	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
497978005256	DNA-binding site [nucleotide binding]; DNA binding site
497978005257	UTRA domain; Region: UTRA; pfam07702
497978005258	putative oxidoreductase; Provisional; Region: PRK08275
497978005259	L-aspartate oxidase; Provisional; Region: PRK06175
497978005260	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
497978005261	Ferredoxin [Energy production and conversion]; Region: COG1146
497978005262	taurine ABC transporter, periplasmic binding protein; Region: taurine_ABC_bnd; TIGR01729
497978005263	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432
497978005264	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
497978005265	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
497978005266	dimer interface [polypeptide binding]; other site
497978005267	conserved gate region; other site
497978005268	putative PBP binding loops; other site
497978005269	ABC-ATPase subunit interface; other site
497978005270	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
497978005271	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
497978005272	Walker A/P-loop; other site
497978005273	ATP binding site [chemical binding]; other site
497978005274	Q-loop/lid; other site
497978005275	ABC transporter signature motif; other site
497978005276	Walker B; other site
497978005277	D-loop; other site
497978005278	H-loop/switch region; other site
497978005279	HEAT repeats; Region: HEAT_2; pfam13646
497978005280	HEAT repeats; Region: HEAT_2; pfam13646
497978005281	HEAT repeats; Region: HEAT_2; pfam13646
497978005282	Protein of unknown function (DUF971); Region: DUF971; pfam06155
497978005283	alpha-ketoglutarate transporter; Provisional; Region: PRK10406
497978005284	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
497978005285	putative substrate translocation pore; other site
497978005286	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
497978005287	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
497978005288	N-terminal plug; other site
497978005289	ligand-binding site [chemical binding]; other site
497978005290	aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273
497978005291	Aspartase; Region: Aspartase; cd01357
497978005292	active sites [active]
497978005293	tetramer interface [polypeptide binding]; other site
497978005294	cell density-dependent motility repressor; Provisional; Region: PRK10082
497978005295	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
497978005296	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
497978005297	dimerization interface [polypeptide binding]; other site
497978005298	Transcriptional regulator [Transcription]; Region: LysR; COG0583
497978005299	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
497978005300	The C-terminal substrate binding domain of LysR-type transcriptional regulators that are involved in the catabolism of dinitrotoluene, naphthalene and gamma-hexachlorohexane; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_NahR_LinR_like; cd08459
497978005301	substrate binding pocket [chemical binding]; other site
497978005302	dimerization interface [polypeptide binding]; other site
497978005303	acetyl-CoA acetyltransferase; Provisional; Region: PRK06954
497978005304	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
497978005305	dimer interface [polypeptide binding]; other site
497978005306	active site
497978005307	Short chain fatty acids transporter [Lipid metabolism]; Region: AtoE; COG2031
497978005308	3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428
497978005309	Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788
497978005310	Transcriptional regulator [Transcription]; Region: LysR; COG0583
497978005311	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
497978005312	TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440
497978005313	putative dimerization interface [polypeptide binding]; other site
497978005314	H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610
497978005315	fructuronate transporter; Provisional; Region: PRK10034; cl15264
497978005316	3-hydroxybutyrate dehydrogenase; Provisional; Region: PRK12429
497978005317	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
497978005318	NAD(P) binding site [chemical binding]; other site
497978005319	active site
497978005320	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
497978005321	Helix-turn-helix domain; Region: HTH_18; pfam12833
497978005322	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
497978005323	benzoate transport; Region: 2A0115; TIGR00895
497978005324	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
497978005325	putative substrate translocation pore; other site
497978005326	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
497978005327	Dienelactone hydrolase family; Region: DLH; pfam01738
497978005328	SnoaL-like domain; Region: SnoaL_2; pfam12680
497978005329	short chain dehydrogenase; Provisional; Region: PRK08265
497978005330	classical (c) SDRs; Region: SDR_c; cd05233
497978005331	NAD(P) binding site [chemical binding]; other site
497978005332	active site
497978005333	Flavin reductase like domain; Region: Flavin_Reduct; smart00903
497978005334	Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; cl01768
497978005335	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
497978005336	Helix-turn-helix domain; Region: HTH_18; pfam12833
497978005337	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
497978005338	anthranilate dioxygenase reductase; Provisional; Region: antC; PRK11872
497978005339	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
497978005340	catalytic loop [active]
497978005341	iron binding site [ion binding]; other site
497978005342	Benzoate dioxygenase reductase (BenDO) FAD/NAD binding domain. Oxygenases oxidize hydrocarbons using dioxygen as the oxidant. As a Class I bacterial dioxygenases, benzoate dioxygenase like proteins combine an [2Fe-2S] cluster containing N-terminal...; Region: BenDO_FAD_NAD; cd06209
497978005343	FAD binding pocket [chemical binding]; other site
497978005344	FAD binding motif [chemical binding]; other site
497978005345	phosphate binding motif [ion binding]; other site
497978005346	beta-alpha-beta structure motif; other site
497978005347	NAD binding pocket [chemical binding]; other site
497978005348	Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667
497978005349	inter-subunit interface; other site
497978005350	anthranilate 1,2-dioxygenase, large subunit; Region: anthran_1_2_A; TIGR03228
497978005351	Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469
497978005352	[2Fe-2S] cluster binding site [ion binding]; other site
497978005353	C-terminal catalytic domain of the oxygenase alpha subunit of Pseudomonas resinovorans strain CA10 anthranilate 1,2-dioxygenase and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_AntDO-like; cd08879
497978005354	putative alpha subunit interface [polypeptide binding]; other site
497978005355	putative active site [active]
497978005356	putative substrate binding site [chemical binding]; other site
497978005357	Fe binding site [ion binding]; other site
497978005358	N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; cl17549
497978005359	molybdate transporter periplasmic protein; Provisional; Region: modA; PRK10677
497978005360	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
497978005361	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
497978005362	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
497978005363	dimer interface [polypeptide binding]; other site
497978005364	conserved gate region; other site
497978005365	putative PBP binding loops; other site
497978005366	ABC-ATPase subunit interface; other site
497978005367	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
497978005368	phosphonate C-P lyase system protein PhnL; Region: CP_lyasePhnL; TIGR02324
497978005369	Walker A/P-loop; other site
497978005370	ATP binding site [chemical binding]; other site
497978005371	Q-loop/lid; other site
497978005372	ABC transporter signature motif; other site
497978005373	Walker B; other site
497978005374	D-loop; other site
497978005375	H-loop/switch region; other site
497978005376	2,3-dihydroxybenzoate-2,3-dehydrogenase; Validated; Region: PRK08220
497978005377	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
497978005378	NAD(P) binding site [chemical binding]; other site
497978005379	active site
497978005380	Isochorismatase, also known as 2,3 dihydro-2,3 dihydroxybenzoate synthase, catalyses the conversion of isochorismate, in the presence of water, to 2,3-dihydroxybenzoate and pyruvate, via the hydrolysis of a vinyl ether, an uncommon reaction in biological...; Region: isochorismatase; cd01013
497978005381	hydrophobic substrate binding pocket; other site
497978005382	Isochorismatase family; Region: Isochorismatase; pfam00857
497978005383	active site
497978005384	conserved cis-peptide bond; other site
497978005385	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cl17326
497978005386	metal binding site 2 [ion binding]; metal-binding site
497978005387	putative DNA binding helix; other site
497978005388	metal binding site 1 [ion binding]; metal-binding site
497978005389	dimer interface [polypeptide binding]; other site
497978005390	structural Zn2+ binding site [ion binding]; other site
497978005391	5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737
497978005392	Bacillus subtilis YhcR endonuclease and related proteins, N-terminal metallophosphatase domain; Region: MPP_YhcR_N; cd07412
497978005393	putative active site [active]
497978005394	putative metal binding site [ion binding]; other site
497978005395	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
497978005396	polyphosphate kinase; Provisional; Region: PRK05443
497978005397	Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089
497978005398	Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503
497978005399	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
497978005400	putative active site [active]
497978005401	catalytic site [active]
497978005402	Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168
497978005403	putative domain interface [polypeptide binding]; other site
497978005404	putative active site [active]
497978005405	catalytic site [active]
497978005406	coenzyme PQQ synthesis protein PqqA; Provisional; Region: pqqA; PRK00284
497978005407	pyrroloquinoline quinone biosynthesis protein PqqB; Provisional; Region: PRK05184
497978005408	coenzyme PQQ biosynthesis protein B; Region: PQQ_syn_pqqB; TIGR02108
497978005409	pyrroloquinoline quinone biosynthesis protein PqqC; Provisional; Region: PRK05157
497978005410	pyrroloquinoline quinone biosynthesis protein PqqD; Provisional; Region: PRK02079
497978005411	pyrroloquinoline quinone biosynthesis protein PqqE; Provisional; Region: PRK05301
497978005412	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
497978005413	FeS/SAM binding site; other site
497978005414	radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085
497978005415	Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355
497978005416	renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301
497978005417	active site
497978005418	dimer interface [polypeptide binding]; other site
497978005419	MUG-like Uracil-DNA glycosylase enzyme family; Region: UDG_MUG_like; cd10032
497978005420	putative active site [active]
497978005421	Putative catalytic domain, repeat 1, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_1; cd09111
497978005422	PLD-like domain; Region: PLDc_2; pfam13091
497978005423	putative active site [active]
497978005424	catalytic site [active]
497978005425	Putative catalytic domain, repeat 2, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_2; cd09113
497978005426	PLD-like domain; Region: PLDc_2; pfam13091
497978005427	putative active site [active]
497978005428	catalytic site [active]
497978005429	Catalase-like heme-binding proteins similar to the uncharacterized y4iL; Region: y4iL_like; cd08152
497978005430	putative heme binding pocket [chemical binding]; other site
497978005431	class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300
497978005432	S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase; Region: adh_III_F_hyde; TIGR02818
497978005433	substrate binding site [chemical binding]; other site
497978005434	catalytic Zn binding site [ion binding]; other site
497978005435	NAD binding site [chemical binding]; other site
497978005436	structural Zn binding site [ion binding]; other site
497978005437	dimer interface [polypeptide binding]; other site
497978005438	P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539
497978005439	P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188
497978005440	PapC N-terminal domain; Region: PapC_N; pfam13954
497978005441	Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577
497978005442	PapC C-terminal domain; Region: PapC_C; pfam13953
497978005443	P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121
497978005444	Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345
497978005445	Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753
497978005446	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
497978005447	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
497978005448	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
497978005449	P-loop; other site
497978005450	Magnesium ion binding site [ion binding]; other site
497978005451	DEAD-like helicases superfamily; Region: DEXDc; smart00487
497978005452	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
497978005453	ATP binding site [chemical binding]; other site
497978005454	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
497978005455	Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG2607
497978005456	Walker A motif; other site
497978005457	ATP binding site [chemical binding]; other site
497978005458	Walker B motif; other site
497978005459	Beta-lactamase class D [Defense mechanisms]; Region: COG2602
497978005460	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
497978005461	P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539
497978005462	Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; cl17479
497978005463	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
497978005464	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
497978005465	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
497978005466	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
497978005467	Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748
497978005468	Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593
497978005469	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
497978005470	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
497978005471	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
497978005472	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
497978005473	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
497978005474	alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561
497978005475	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
497978005476	The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915
497978005477	Protein export membrane protein; Region: SecD_SecF; cl14618
497978005478	Protein export membrane protein; Region: SecD_SecF; cl14618
497978005479	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
497978005480	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
497978005481	HlyD family secretion protein; Region: HlyD_3; pfam13437
497978005482	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
497978005483	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
497978005484	active site
497978005485	phosphorylation site [posttranslational modification]
497978005486	intermolecular recognition site; other site
497978005487	dimerization interface [polypeptide binding]; other site
497978005488	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
497978005489	DNA binding site [nucleotide binding]
497978005490	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
497978005491	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
497978005492	dimerization interface [polypeptide binding]; other site
497978005493	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
497978005494	dimer interface [polypeptide binding]; other site
497978005495	phosphorylation site [posttranslational modification]
497978005496	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
497978005497	ATP binding site [chemical binding]; other site
497978005498	Mg2+ binding site [ion binding]; other site
497978005499	G-X-G motif; other site
497978005500	Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625
497978005501	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220
497978005502	dimerization interface [polypeptide binding]; other site
497978005503	putative DNA binding site [nucleotide binding]; other site
497978005504	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
497978005505	putative Zn2+ binding site [ion binding]; other site
497978005506	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
497978005507	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
497978005508	Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028
497978005509	classical (c) SDRs; Region: SDR_c; cd05233
497978005510	NAD(P) binding site [chemical binding]; other site
497978005511	active site
497978005512	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
497978005513	classical (c) SDRs; Region: SDR_c; cd05233
497978005514	NAD(P) binding site [chemical binding]; other site
497978005515	active site
497978005516	PAAR motif; Region: PAAR_motif; pfam05488
497978005517	Phage antirepressor protein KilAC domain; Region: ANT; pfam03374
497978005518	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
497978005519	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
497978005520	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
497978005521	non-specific DNA binding site [nucleotide binding]; other site
497978005522	salt bridge; other site
497978005523	sequence-specific DNA binding site [nucleotide binding]; other site
497978005524	HD domain; Region: HD_4; pfam13328
497978005525	Survival protein SurE; Region: SurE; pfam01975
497978005526	type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844
497978005527	GH3 auxin-responsive promoter; Region: GH3; pfam03321
497978005528	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
497978005529	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
497978005530	putative substrate translocation pore; other site
497978005531	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
497978005532	Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566
497978005533	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
497978005534	HlyD family secretion protein; Region: HlyD_3; pfam13437
497978005535	indole acetimide hydrolase; Validated; Region: PRK07488
497978005536	Amidase; Region: Amidase; pfam01425
497978005537	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
497978005538	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
497978005539	DNA binding residues [nucleotide binding]
497978005540	dimerization interface [polypeptide binding]; other site
497978005541	Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cl00246
497978005542	FAD binding site [chemical binding]; other site
497978005543	Methylene-tetrahydrofolate reductase C terminal; Region: MTHFR_C; pfam12225
497978005544	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883
497978005545	nudix motif; other site
497978005546	Uncharacterized conserved protein [General function prediction only]; Region: COG4111
497978005547	putative nicotinate phosphoribosyltransferase; Provisional; Region: PRK09198
497978005548	pre-B-cell colony-enhancing factor (PBEF)-like. The mammalian members of this group of nicotinate phosphoribosyltransferases (NAPRTases) were originally identified as genes whose expression is upregulated upon activation in lymphoid cells. In general; Region: PBEF_like; cd01569
497978005549	active site
497978005550	Phosphoribosylpyrophosphate synthetase [Nucleotide transport and metabolism / Amino acid transport and metabolism]; Region: PrsA; COG0462
497978005551	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
497978005552	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
497978005553	active site
497978005554	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
497978005555	Cupin domain; Region: Cupin_2; cl17218
497978005556	Helix-turn-helix domain; Region: HTH_18; pfam12833
497978005557	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
497978005558	Coenzyme A binding pocket [chemical binding]; other site
497978005559	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
497978005560	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
497978005561	Walker A/P-loop; other site
497978005562	ATP binding site [chemical binding]; other site
497978005563	Q-loop/lid; other site
497978005564	ABC transporter signature motif; other site
497978005565	Walker B; other site
497978005566	D-loop; other site
497978005567	H-loop/switch region; other site
497978005568	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
497978005569	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
497978005570	ABC-ATPase subunit  interface; other site
497978005571	dimer interface [polypeptide binding]; other site
497978005572	putative PBP binding regions; other site
497978005573	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
497978005574	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
497978005575	intersubunit interface [polypeptide binding]; other site
497978005576	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
497978005577	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283
497978005578	putative NAD(P) binding site [chemical binding]; other site
497978005579	putative substrate binding site [chemical binding]; other site
497978005580	catalytic Zn binding site [ion binding]; other site
497978005581	structural Zn binding site [ion binding]; other site
497978005582	dimer interface [polypeptide binding]; other site
497978005583	Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599
497978005584	Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599
497978005585	Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917
497978005586	AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719
497978005587	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
497978005588	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
497978005589	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
497978005590	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
497978005591	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
497978005592	4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332
497978005593	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
497978005594	putative substrate translocation pore; other site
497978005595	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
497978005596	Escherichia coli Gne (a nucleoside-diphosphate-sugar 4-epimerase)-like, extended (e) SDRs; Region: Gne_like_SDR_e; cd05238
497978005597	putative NAD(P) binding site [chemical binding]; other site
497978005598	active site
497978005599	putative substrate binding site [chemical binding]; other site
497978005600	Transcriptional regulator [Transcription]; Region: LysR; COG0583
497978005601	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
497978005602	The C-terminal substrate binding domain of galactose-binding protein regulator contains the type 2 periplasmic binding fold; Region: PBP2_GbpR; cd08435
497978005603	putative dimerization interface [polypeptide binding]; other site
497978005604	Fumarylacetoacetate (FAA) hydrolase family protein [General function prediction only]; Region: COG3970
497978005605	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
497978005606	dihydroxy-acid dehydratase; Provisional; Region: PRK13017
497978005607	NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012
497978005608	Alpha-Ketoglutaric Semialdehyde Dehydrogenase; Region: ALDH_KGSADH; cd07129
497978005609	dimer interface [polypeptide binding]; other site
497978005610	NADP binding site [chemical binding]; other site
497978005611	catalytic residues [active]
497978005612	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
497978005613	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
497978005614	AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246
497978005615	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
497978005616	putative substrate translocation pore; other site
497978005617	Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566
497978005618	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
497978005619	HlyD family secretion protein; Region: HlyD_3; pfam13437
497978005620	RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931
497978005621	type I secretion C-terminal target domain (VC_A0849 subclass); Region: T1SS_VCA0849; TIGR03661
497978005622	Antitoxin of toxin-antitoxin stability system N-terminal; Region: RelB_N; pfam12910
497978005623	hypothetical protein; Validated; Region: PRK06201
497978005624	Demethylmenaquinone methyltransferase [Coenzyme metabolism]; Region: MenG; COG0684
497978005625	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
497978005626	Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173
497978005627	ligand binding site [chemical binding]; other site
497978005628	NAD binding site [chemical binding]; other site
497978005629	dimerization interface [polypeptide binding]; other site
497978005630	catalytic site [active]
497978005631	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
497978005632	Major Facilitator Superfamily; Region: MFS_1; pfam07690
497978005633	putative substrate translocation pore; other site
497978005634	IclR helix-turn-helix domain; Region: HTH_IclR; cl17605
497978005635	Transcriptional regulator [Transcription]; Region: IclR; COG1414
497978005636	Bacterial transcriptional regulator; Region: IclR; pfam01614
497978005637	Protein of unknown function, DUF606; Region: DUF606; pfam04657
497978005638	Protein of unknown function, DUF606; Region: DUF606; pfam04657
497978005639	Transcriptional regulator [Transcription]; Region: LysR; COG0583
497978005640	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
497978005641	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
497978005642	putative effector binding pocket; other site
497978005643	dimerization interface [polypeptide binding]; other site
497978005644	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
497978005645	putative substrate translocation pore; other site
497978005646	Major Facilitator Superfamily; Region: MFS_1; pfam07690
497978005647	SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450
497978005648	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567
497978005649	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
497978005650	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
497978005651	DNA-binding site [nucleotide binding]; DNA binding site
497978005652	The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866
497978005653	Dicarboxylate carrier protein MatC N-terminus; Region: MatC_N; pfam07158
497978005654	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
497978005655	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221
497978005656	Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618
497978005657	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
497978005658	active site
497978005659	4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332
497978005660	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
497978005661	putative substrate translocation pore; other site
497978005662	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
497978005663	haemagglutination activity domain; Region: Haemagg_act; pfam05860
497978005664	Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; cl01733
497978005665	Possible hemagglutinin (DUF637); Region: DUF637; pfam04830
497978005666	Pre-toxin domain with VENN motif; Region: PT-VENN; pfam04829
497978005667	MafB19-like deaminase; Region: MafB19-deam; pfam14437
497978005668	Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831
497978005669	POTRA domain, ShlB-type; Region: POTRA_2; pfam08479
497978005670	Haemolysin secretion/activation protein ShlB/FhaC/HecB; Region: ShlB; pfam03865
497978005671	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
497978005672	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
497978005673	M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like2; cd05667
497978005674	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
497978005675	metal binding site [ion binding]; metal-binding site
497978005676	putative dimer interface [polypeptide binding]; other site
497978005677	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
497978005678	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
497978005679	Kef-type K+ transport systems, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: Kch; COG1226
497978005680	TrkA-N domain; Region: TrkA_N; pfam02254
497978005681	dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606
497978005682	Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995
497978005683	LysR family transcriptional regulator; Provisional; Region: PRK14997
497978005684	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
497978005685	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_4; cd08473
497978005686	putative effector binding pocket; other site
497978005687	putative dimerization interface [polypeptide binding]; other site
497978005688	Isochorismatase family; Region: Isochorismatase; pfam00857
497978005689	YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012
497978005690	catalytic triad [active]
497978005691	dimer interface [polypeptide binding]; other site
497978005692	conserved cis-peptide bond; other site
497978005693	Uncharacterized conserved protein [Function unknown]; Region: COG1359
497978005694	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
497978005695	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
497978005696	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
497978005697	Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706
497978005698	Transcriptional regulator; Region: Rrf2; pfam02082
497978005699	Rrf2 family protein; Region: rrf2_super; TIGR00738
497978005700	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
497978005701	Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693
497978005702	Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141
497978005703	potential catalytic triad [active]
497978005704	conserved cys residue [active]
497978005705	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
497978005706	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
497978005707	DNA binding residues [nucleotide binding]
497978005708	RibD C-terminal domain; Region: RibD_C; cl17279
497978005709	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
497978005710	Uncharacterized conserved protein [Function unknown]; Region: COG3268
497978005711	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
497978005712	NAD(P) binding site [chemical binding]; other site
497978005713	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
497978005714	Old yellow enzyme (OYE)-related FMN binding domain, group 2.  Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_2_FMN; cd04733
497978005715	putative active site [active]
497978005716	putative FMN binding site [chemical binding]; other site
497978005717	putative substrate binding site [chemical binding]; other site
497978005718	putative catalytic residue [active]
497978005719	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
497978005720	MarR family; Region: MarR; pfam01047
497978005721	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
497978005722	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
497978005723	Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141
497978005724	Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693
497978005725	potential catalytic triad [active]
497978005726	conserved cys residue [active]
497978005727	2-oxoglutarate dehydrogenase E2 component; Region: PLN02226
497978005728	Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753
497978005729	Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156
497978005730	tetramer interface [polypeptide binding]; other site
497978005731	heme binding pocket [chemical binding]; other site
497978005732	NADPH binding site [chemical binding]; other site
497978005733	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
497978005734	Acetoacetate decarboxylase (ADC); Region: ADC; cl01919
497978005735	aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381
497978005736	Coniferyl aldehyde dehydrogenase-like; Region: ALDH_CALDH_CalB; cd07133
497978005737	NAD(P) binding site [chemical binding]; other site
497978005738	catalytic residues [active]
497978005739	putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824
497978005740	PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276
497978005741	NAD(P) binding site [chemical binding]; other site
497978005742	Predicted symporter [General function prediction only]; Region: DhlC; COG4147
497978005743	Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480
497978005744	Na binding site [ion binding]; other site
497978005745	Protein of unknown function, DUF485; Region: DUF485; pfam04341
497978005746	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07008
497978005747	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
497978005748	acyl-activating enzyme (AAE) consensus motif; other site
497978005749	AMP binding site [chemical binding]; other site
497978005750	active site
497978005751	CoA binding site [chemical binding]; other site
497978005752	Propionate catabolism activator; Region: PrpR_N; pfam06506
497978005753	psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974
497978005754	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
497978005755	Walker A motif; other site
497978005756	ATP binding site [chemical binding]; other site
497978005757	Walker B motif; other site
497978005758	arginine finger; other site
497978005759	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
497978005760	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
497978005761	classical (c) SDRs; Region: SDR_c; cd05233
497978005762	NAD(P) binding site [chemical binding]; other site
497978005763	active site
497978005764	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
497978005765	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
497978005766	active site
497978005767	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
497978005768	catalytic core [active]
497978005769	Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154
497978005770	Phosphotransferase enzyme family; Region: APH; pfam01636
497978005771	putative active site [active]
497978005772	putative substrate binding site [chemical binding]; other site
497978005773	ATP binding site [chemical binding]; other site
497978005774	NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012
497978005775	Alpha-Ketoglutaric Semialdehyde Dehydrogenase; Region: ALDH_KGSADH; cd07129
497978005776	dimer interface [polypeptide binding]; other site
497978005777	NADP binding site [chemical binding]; other site
497978005778	catalytic residues [active]
497978005779	Uncharacterized protein conserved in bacteria [Function unknown]; Region: GguC; COG3802
497978005780	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
497978005781	4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332
497978005782	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
497978005783	putative substrate translocation pore; other site
497978005784	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
497978005785	dihydroxy-acid dehydratase; Validated; Region: PRK06131
497978005786	Transcriptional regulators [Transcription]; Region: FadR; COG2186
497978005787	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
497978005788	DNA-binding site [nucleotide binding]; DNA binding site
497978005789	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
497978005790	Bacterial protein of unknown function (Gcw_chp); Region: Gcw_chp; pfam09694
497978005791	DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906
497978005792	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
497978005793	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
497978005794	dimerization interface [polypeptide binding]; other site
497978005795	muconate and chloromuconate cycloisomerases; Region: mucon_cyclo; TIGR02534
497978005796	Muconate Lactonizing Enzyme (MLE), an homooctameric enzyme, catalyses the conversion of cis,cis-muconate (CCM) to muconolactone (ML) in the catechol branch of the beta-ketoadipate pathway. This pathway is used in soil microbes to breakdown lignin-derived...; Region: MLE; cd03318
497978005797	octamer interface [polypeptide binding]; other site
497978005798	active site
497978005799	muconolactone delta-isomerase; Region: muco_delta; TIGR03221
497978005800	catechol 1,2-dioxygenase, proteobacterial; Region: catechol_proteo; TIGR02439
497978005801	Catechol 1,2 dioxygenase (1,2-CTD) catalyzes an intradiol cleavage reaction of catechol to form cis,cis-muconate. 1,2-CTDs is homodimers with one catalytic non-heme ferric ion per monomer. They belong to the aromatic dioxygenase family, a family of...; Region: 1,2-CTD; cd03460
497978005802	dimer interface [polypeptide binding]; other site
497978005803	active site
497978005804	3-oxoacid CoA-transferase, A subunit; Region: pcaI_scoA_fam; TIGR02429
497978005805	3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428
497978005806	beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050
497978005807	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
497978005808	dimer interface [polypeptide binding]; other site
497978005809	active site
497978005810	3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427
497978005811	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
497978005812	Protein related to penicillin acylase [General function prediction only]; Region: COG2366
497978005813	The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid.  N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467
497978005814	The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid.  N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467
497978005815	active site
497978005816	Escherichia coli NAD+-dependent phenylacetaldehyde dehydrogenase PadA-like; Region: ALDH_PADH_NahF; cd07113
497978005817	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
497978005818	NAD(P) binding site [chemical binding]; other site
497978005819	catalytic residues [active]
497978005820	tyramine oxidase; Provisional; Region: tynA; PRK14696
497978005821	Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833
497978005822	Copper amine oxidase, N3 domain; Region: Cu_amine_oxidN3; pfam02728
497978005823	Copper amine oxidase, enzyme domain; Region: Cu_amine_oxid; pfam01179
497978005824	DNA-binding transcriptional activator FeaR; Provisional; Region: PRK09685
497978005825	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
497978005826	Flavin reductase like domain; Region: Flavin_Reduct; smart00903
497978005827	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
497978005828	Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal  ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185
497978005829	FMN-binding pocket [chemical binding]; other site
497978005830	flavin binding motif; other site
497978005831	phosphate binding motif [ion binding]; other site
497978005832	beta-alpha-beta structure motif; other site
497978005833	NAD binding pocket [chemical binding]; other site
497978005834	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
497978005835	catalytic loop [active]
497978005836	iron binding site [ion binding]; other site
497978005837	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
497978005838	classical (c) SDRs; Region: SDR_c; cd05233
497978005839	NAD(P) binding site [chemical binding]; other site
497978005840	active site
497978005841	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
497978005842	benzoate 1,2-dioxygenase, large subunit; Region: benzo_1_2_benA; TIGR03229
497978005843	Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469
497978005844	[2Fe-2S] cluster binding site [ion binding]; other site
497978005845	C-terminal catalytic domain of the oxygenase alpha subunit of Pseudomonas resinovorans strain CA10 anthranilate 1,2-dioxygenase and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_AntDO-like; cd08879
497978005846	putative alpha subunit interface [polypeptide binding]; other site
497978005847	putative active site [active]
497978005848	putative substrate binding site [chemical binding]; other site
497978005849	Fe binding site [ion binding]; other site
497978005850	SnoaL-like domain; Region: SnoaL_4; pfam13577
497978005851	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
497978005852	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
497978005853	active site
497978005854	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
497978005855	Amidase; Region: Amidase; cl11426
497978005856	Transcriptional regulators [Transcription]; Region: MarR; COG1846
497978005857	Winged helix DNA-binding domain; Region: HTH_27; pfam13463
497978005858	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
497978005859	Major Facilitator Superfamily; Region: MFS_1; pfam07690
497978005860	putative substrate translocation pore; other site
497978005861	outer membrane porin, OprD family; Region: OprD; pfam03573
497978005862	short chain dehydrogenase; Provisional; Region: PRK08251
497978005863	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
497978005864	NAD(P) binding site [chemical binding]; other site
497978005865	active site
497978005866	Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040
497978005867	catalytic core [active]
497978005868	thiamine kinase; Region: ycfN_thiK; TIGR02721
497978005869	Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154
497978005870	putative active site [active]
497978005871	putative substrate binding site [chemical binding]; other site
497978005872	ATP binding site [chemical binding]; other site
497978005873	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
497978005874	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
497978005875	active site
497978005876	Transcriptional regulator [Transcription]; Region: LysR; COG0583
497978005877	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
497978005878	The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417
497978005879	substrate binding pocket [chemical binding]; other site
497978005880	dimerization interface [polypeptide binding]; other site
497978005881	beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Region: pcaR_pcaU; TIGR02431
497978005882	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
497978005883	Bacterial transcriptional regulator; Region: IclR; pfam01614
497978005884	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
497978005885	Predicted transporter component [General function prediction only]; Region: COG2391
497978005886	Domain of unknown function (DUF4341); Region: DUF4341; pfam14241
497978005887	7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695
497978005888	membrane-bound PQQ-dependent dehydrogenase, glucose/quinate/shikimate family; Region: PQQ_membr_DH; TIGR03074
497978005889	Membrane-bound PQQ-dependent glucose dehydrogenase; Region: PQQ_mGDH; cd10280
497978005890	Trp docking motif [polypeptide binding]; other site
497978005891	putative active site [active]
497978005892	Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966
497978005893	Right handed beta helix region; Region: Beta_helix; pfam13229
497978005894	Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502
497978005895	3-dehydroquinate dehydratase [Amino acid transport and metabolism]; Region: AroD; COG0710
497978005896	active site
497978005897	catalytic residue [active]
497978005898	dimer interface [polypeptide binding]; other site
497978005899	Protocatechuate 3,4-dioxygenase beta subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PcaH; COG3485
497978005900	Protocatechuate 3,4-dioxygenase (3,4-PCD) , alpha subunit. 3,4-PCD catalyzes the oxidative ring cleavage of 3,4-dihydroxybenzoate to produce beta-carboxy-cis,cis-muconate. 3,4-PCDs are large aggregates of 12 protomers, each composed of an alpha- and...; Region: 3,4-PCD_alpha; cd03463
497978005901	heterodimer interface [polypeptide binding]; other site
497978005902	active site
497978005903	Protocatechuate 3,4-dioxygenase (3,4-PCD) , beta subunit. 3,4-PCD catalyzes the oxidative ring cleavage of 3,4-dihydroxybenzoate to produce beta-carboxy-cis,cis-muconate. 3,4-PCDs are large aggregates of 12 protomers, each composed of an alpha- and...; Region: 3,4-PCD_beta; cd03464
497978005904	heterodimer interface [polypeptide binding]; other site
497978005905	multimer interface [polypeptide binding]; other site
497978005906	protocatechuate 3,4-dioxygenase, beta subunit; Region: protocat_beta; TIGR02422
497978005907	active site
497978005908	Carboxymuconolactone decarboxylase family; Region: CMD; cl00460
497978005909	benzoate transport; Region: 2A0115; TIGR00895
497978005910	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
497978005911	putative substrate translocation pore; other site
497978005912	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
497978005913	3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427
497978005914	3-carboxy-cis,cis-muconate cycloisomerase; Provisional; Region: PRK09053
497978005915	prokaryotic 3-carboxy-cis,cis-muconate cycloisomerase (CMLE)_like; Region: pCLME; cd01597
497978005916	tetramer interface [polypeptide binding]; other site
497978005917	active site
497978005918	beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050
497978005919	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
497978005920	dimer interface [polypeptide binding]; other site
497978005921	active site
497978005922	3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428
497978005923	3-oxoacid CoA-transferase, A subunit; Region: pcaI_scoA_fam; TIGR02429
497978005924	CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516
497978005925	substrate binding site; other site
497978005926	dimer interface; other site
497978005927	Septum formation initiator; Region: DivIC; cl17659
497978005928	Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919
497978005929	Predicted membrane protein [Function unknown]; Region: COG2323
497978005930	enolase; Provisional; Region: eno; PRK00077
497978005931	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
497978005932	dimer interface [polypeptide binding]; other site
497978005933	metal binding site [ion binding]; metal-binding site
497978005934	substrate binding pocket [chemical binding]; other site
497978005935	2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198
497978005936	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
497978005937	CTP synthetase; Validated; Region: pyrG; PRK05380
497978005938	CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113
497978005939	Catalytic site [active]
497978005940	active site
497978005941	UTP binding site [chemical binding]; other site
497978005942	Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746
497978005943	active site
497978005944	putative oxyanion hole; other site
497978005945	catalytic triad [active]
497978005946	Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687
497978005947	Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118
497978005948	Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; Region: COG0429
497978005949	SGNH_hydrolase subfamily, FeeA, FeeB and similar esterases/lipases. FeeA and FeeB are part of a biosynthetic gene cluster and may participate in the biosynthesis of long-chain N-acyltyrosines by providing saturated and unsaturated fatty acids, which it...; Region: FeeA_FeeB_like; cd01836
497978005950	active site
497978005951	catalytic triad [active]
497978005952	oxyanion hole [active]
497978005953	SnoaL-like domain; Region: SnoaL_2; pfam12680
497978005954	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
497978005955	2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli  is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930
497978005956	active site
497978005957	FMN binding site [chemical binding]; other site
497978005958	2,4-decadienoyl-CoA binding site; other site
497978005959	catalytic residue [active]
497978005960	4Fe-4S cluster binding site [ion binding]; other site
497978005961	Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446
497978005962	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
497978005963	Predicted transcriptional regulators [Transcription]; Region: COG1695
497978005964	Transcriptional regulator PadR-like family; Region: PadR; cl17335
497978005965	Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400
497978005966	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
497978005967	phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12755
497978005968	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
497978005969	hypothetical protein; Provisional; Region: PRK02237
497978005970	ATP-dependent Clp protease ATP-binding subunit clpA; Region: ClpA; TIGR02639
497978005971	Clp amino terminal domain; Region: Clp_N; pfam02861
497978005972	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
497978005973	Walker A motif; other site
497978005974	ATP binding site [chemical binding]; other site
497978005975	Walker B motif; other site
497978005976	arginine finger; other site
497978005977	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
497978005978	Walker A motif; other site
497978005979	ATP binding site [chemical binding]; other site
497978005980	Walker B motif; other site
497978005981	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
497978005982	Uncharacterized conserved protein [Function unknown]; Region: COG2127
497978005983	Membrane-anchored protein predicted to be involved in regulation of amylopullulanase [Carbohydrate transport and metabolism]; Region: COG4945
497978005984	N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436
497978005985	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
497978005986	Protein of unknown function DUF45; Region: DUF45; pfam01863
497978005987	RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398
497978005988	tetramer (dimer of dimers) interface [polypeptide binding]; other site
497978005989	active site
497978005990	dimer interface [polypeptide binding]; other site
497978005991	threonine dehydratase; Reviewed; Region: PRK09224
497978005992	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
497978005993	tetramer interface [polypeptide binding]; other site
497978005994	pyridoxal 5'-phosphate binding site [chemical binding]; other site
497978005995	catalytic residue [active]
497978005996	First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906
497978005997	putative Ile/Val binding site [chemical binding]; other site
497978005998	Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907
497978005999	putative Ile/Val binding site [chemical binding]; other site
497978006000	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
497978006001	TrkA-N domain; Region: TrkA_N; pfam02254
497978006002	Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168
497978006003	potassium uptake protein, TrkH family; Region: 2a38; TIGR00933
497978006004	The outer membrane phospholipase A (OMPLA) is an integral membrane enzyme that catalyses the hydrolysis of acylester bonds in phospholipids using calcium as a cofactor. The enzyme has a fold of transmembrane beta-barrels and is widespread among...; Region: OMPLA; cd00541
497978006005	dimerization interface [polypeptide binding]; other site
497978006006	substrate binding site [chemical binding]; other site
497978006007	active site
497978006008	calcium binding site [ion binding]; other site
497978006009	Predicted Zn-dependent peptidases, insulinase-like [General function prediction only]; Region: COG1026
497978006010	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
497978006011	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
497978006012	Peptidase M16C associated; Region: M16C_assoc; pfam08367
497978006013	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
497978006014	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
497978006015	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
497978006016	N-terminal plug; other site
497978006017	ligand-binding site [chemical binding]; other site
497978006018	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
497978006019	Adenosine kinase (AK) catalyzes the phosphorylation of ribofuranosyl-containing nucleoside analogues at the 5'-hydroxyl using ATP or GTP as the phosphate donor.The physiological function of AK is associated with the regulation of extracellular...; Region: adenosine_kinase; cd01168
497978006020	substrate binding site [chemical binding]; other site
497978006021	ATP binding site [chemical binding]; other site
497978006022	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467
497978006023	iron-sulfur cluster [ion binding]; other site
497978006024	[2Fe-2S] cluster binding site [ion binding]; other site
497978006025	Protein of unknown function (DUF1449); Region: DUF1449; pfam07290
497978006026	cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097
497978006027	Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562
497978006028	cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219
497978006029	Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322
497978006030	Membrane bound YbgT-like protein; Region: YbgT_YccB; pfam08173
497978006031	Cyd operon protein YbgE (Cyd_oper_YbgE); Region: Cyd_oper_YbgE; pfam09600
497978006032	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
497978006033	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
497978006034	Coenzyme A binding pocket [chemical binding]; other site
497978006035	Uncharacterized protein conserved in bacteria (DUF2057); Region: DUF2057; pfam09829
497978006036	Nitroreductase-like family 4.  A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_4; cd02140
497978006037	dimer interface [polypeptide binding]; other site
497978006038	FMN binding site [chemical binding]; other site
497978006039	signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416
497978006040	SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881
497978006041	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
497978006042	P loop; other site
497978006043	GTP binding site [chemical binding]; other site
497978006044	Protein of unknown function (DUF2750); Region: DUF2750; pfam11042
497978006045	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_10; cd04623
497978006046	FOG: CBS domain [General function prediction only]; Region: COG0517
497978006047	acetylornithine aminotransferase; Provisional; Region: PRK02627
497978006048	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
497978006049	inhibitor-cofactor binding pocket; inhibition site
497978006050	pyridoxal 5'-phosphate binding site [chemical binding]; other site
497978006051	catalytic residue [active]
497978006052	Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028
497978006053	putative GSH binding site [chemical binding]; other site
497978006054	catalytic residues [active]
497978006055	LysR family transcriptional regulator; Provisional; Region: PRK14997
497978006056	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
497978006057	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_4; cd08473
497978006058	putative effector binding pocket; other site
497978006059	putative dimerization interface [polypeptide binding]; other site
497978006060	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
497978006061	active site
497978006062	Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547
497978006063	Uncharacterized protein, possibly involved in utilization of glycolate and propanediol [General function prediction only]; Region: GlcG; COG3193
497978006064	Predicted alpha/beta hydrolase [General function prediction only]; Region: COG4757
497978006065	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
497978006066	bifunctional PTS system fructose-specific transporter subunit IIA/HPr protein; Provisional; Region: PRK11109
497978006067	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
497978006068	active site
497978006069	phosphorylation site [posttranslational modification]
497978006070	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cl00163
497978006071	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
497978006072	dimerization domain swap beta strand [polypeptide binding]; other site
497978006073	regulatory protein interface [polypeptide binding]; other site
497978006074	active site
497978006075	regulatory phosphorylation site [posttranslational modification]; other site
497978006076	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
497978006077	Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080
497978006078	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
497978006079	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
497978006080	Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105
497978006081	1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164
497978006082	putative substrate binding site [chemical binding]; other site
497978006083	putative ATP binding site [chemical binding]; other site
497978006084	PTS system fructose-specific transporter subunits IIBC; Provisional; Region: PRK10712
497978006085	PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569
497978006086	active site
497978006087	P-loop; other site
497978006088	phosphorylation site [posttranslational modification]
497978006089	Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; cl17425
497978006090	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
497978006091	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
497978006092	putative DNA binding site [nucleotide binding]; other site
497978006093	putative Zn2+ binding site [ion binding]; other site
497978006094	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
497978006095	PAS domain; Region: PAS_9; pfam13426
497978006096	putative active site [active]
497978006097	heme pocket [chemical binding]; other site
497978006098	PAS fold; Region: PAS_4; pfam08448
497978006099	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
497978006100	putative active site [active]
497978006101	heme pocket [chemical binding]; other site
497978006102	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
497978006103	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
497978006104	metal binding site [ion binding]; metal-binding site
497978006105	active site
497978006106	I-site; other site
497978006107	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
497978006108	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
497978006109	Ligand Binding Site [chemical binding]; other site
497978006110	dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606
497978006111	Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995
497978006112	Uncharacterized ACR, COG2135; Region: DUF159; pfam02586
497978006113	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
497978006114	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
497978006115	Sulfate transporter family; Region: Sulfate_transp; pfam00916
497978006116	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
497978006117	Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922
497978006118	Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404
497978006119	Peptidase S8 family domain in ProteinaseK-like proteins; Region: Peptidases_S8_PCSK9_ProteinaseK_like; cd04077
497978006120	calcium binding site 2 [ion binding]; other site
497978006121	active site
497978006122	catalytic triad [active]
497978006123	calcium binding site 1 [ion binding]; other site
497978006124	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
497978006125	Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113
497978006126	Kynureninase [Amino acid transport and metabolism]; Region: COG3844
497978006127	kynureninase; Region: kynureninase; TIGR01814
497978006128	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
497978006129	catalytic residue [active]
497978006130	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
497978006131	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
497978006132	Fels-1 Prophage Protein-like; Region: Fels1; pfam05666
497978006133	Fels-1 Prophage Protein-like; Region: Fels1; pfam05666
497978006134	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915
497978006135	Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419
497978006136	motif II; other site
497978006137	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
497978006138	RNA binding surface [nucleotide binding]; other site
497978006139	recombinase A; Provisional; Region: recA; PRK09354
497978006140	RecA is a  bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response.  RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983
497978006141	hexamer interface [polypeptide binding]; other site
497978006142	Walker A motif; other site
497978006143	ATP binding site [chemical binding]; other site
497978006144	Walker B motif; other site
497978006145	recombination regulator RecX; Reviewed; Region: recX; PRK00117
497978006146	tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795
497978006147	UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289
497978006148	UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351
497978006149	active site
497978006150	FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288
497978006151	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892
497978006152	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613
497978006153	UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352
497978006154	trimer interface [polypeptide binding]; other site
497978006155	active site
497978006156	UDP-GlcNAc binding site [chemical binding]; other site
497978006157	lipid binding site [chemical binding]; lipid-binding site
497978006158	Outer membrane protein (OmpH-like); Region: OmpH; pfam03938
497978006159	outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303
497978006160	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
497978006161	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
497978006162	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
497978006163	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
497978006164	Surface antigen; Region: Bac_surface_Ag; pfam01103
497978006165	zinc metallopeptidase RseP; Provisional; Region: PRK10779
497978006166	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
497978006167	active site
497978006168	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
497978006169	protein binding site [polypeptide binding]; other site
497978006170	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
497978006171	protein binding site [polypeptide binding]; other site
497978006172	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
497978006173	putative substrate binding region [chemical binding]; other site
497978006174	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447
497978006175	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670
497978006176	1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436
497978006177	DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288
497978006178	Cytidylyltransferase family; Region: CTP_transf_1; pfam01148
497978006179	CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575
497978006180	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230
497978006181	Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255
497978006182	catalytic residue [active]
497978006183	putative FPP diphosphate  binding site; other site
497978006184	putative FPP binding hydrophobic cleft; other site
497978006185	dimer interface [polypeptide binding]; other site
497978006186	putative IPP diphosphate binding site; other site
497978006187	ribosome recycling factor; Reviewed; Region: frr; PRK00083
497978006188	Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation.  Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520
497978006189	hinge region; other site
497978006190	UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254
497978006191	putative nucleotide binding site [chemical binding]; other site
497978006192	uridine monophosphate binding site [chemical binding]; other site
497978006193	homohexameric interface [polypeptide binding]; other site
497978006194	ribosomal protein S12 methylthiotransferase; Provisional; Region: rimO; PRK14862
497978006195	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
497978006196	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
497978006197	FeS/SAM binding site; other site
497978006198	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
497978006199	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
497978006200	putative active site [active]
497978006201	heme pocket [chemical binding]; other site
497978006202	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
497978006203	dimer interface [polypeptide binding]; other site
497978006204	phosphorylation site [posttranslational modification]
497978006205	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
497978006206	ATP binding site [chemical binding]; other site
497978006207	Mg2+ binding site [ion binding]; other site
497978006208	G-X-G motif; other site
497978006209	nitrogen regulation protein NR(I); Region: ntrC; TIGR01818
497978006210	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
497978006211	active site
497978006212	phosphorylation site [posttranslational modification]
497978006213	intermolecular recognition site; other site
497978006214	dimerization interface [polypeptide binding]; other site
497978006215	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
497978006216	Walker A motif; other site
497978006217	ATP binding site [chemical binding]; other site
497978006218	Walker B motif; other site
497978006219	arginine finger; other site
497978006220	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
497978006221	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
497978006222	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
497978006223	ornithine carbamoyltransferase; Provisional; Region: PRK00779
497978006224	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
497978006225	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
497978006226	Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053
497978006227	catalytic residues [active]
497978006228	active site
497978006229	MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554
497978006230	homotrimer interaction site [polypeptide binding]; other site
497978006231	zinc binding site [ion binding]; other site
497978006232	CDP-binding sites; other site
497978006233	D-amino acid dehydrogenase small subunit; Provisional; Region: PRK12409
497978006234	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
497978006235	hydroxyglutarate oxidase; Provisional; Region: PRK11728
497978006236	fumarate hydratase; Reviewed; Region: fumC; PRK00485
497978006237	Class II fumarases; Region: Fumarase_classII; cd01362
497978006238	active site
497978006239	tetramer interface [polypeptide binding]; other site
497978006240	UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087
497978006241	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
497978006242	NAD(P) binding site [chemical binding]; other site
497978006243	active site
497978006244	sulfur relay protein TusD/DsrE; Region: sulf_tusD_dsrE; TIGR03012
497978006245	Dissimilatory sulfite reductase (desulfoviridin), gamma subunit [Inorganic ion transport and metabolism]; Region: DsrC; COG2920
497978006246	DsrC like protein; Region: DsrC; pfam04358
497978006247	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
497978006248	EamA-like transporter family; Region: EamA; pfam00892
497978006249	EamA-like transporter family; Region: EamA; pfam00892
497978006250	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
497978006251	DNA-binding site [nucleotide binding]; DNA binding site
497978006252	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
497978006253	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
497978006254	pyridoxal 5'-phosphate binding site [chemical binding]; other site
497978006255	homodimer interface [polypeptide binding]; other site
497978006256	catalytic residue [active]
497978006257	Predicted transcriptional regulators [Transcription]; Region: COG1733
497978006258	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
497978006259	Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303
497978006260	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
497978006261	dimer interface [polypeptide binding]; other site
497978006262	putative functional site; other site
497978006263	putative MPT binding site; other site
497978006264	bifunctional molybdenum cofactor biosynthesis protein MoaC/MogA; Provisional; Region: moaC; PRK03604
497978006265	MoaC family. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine derivative to the precursor...; Region: MoaC; cl00242
497978006266	trimer interface [polypeptide binding]; other site
497978006267	dimer interface [polypeptide binding]; other site
497978006268	putative active site [active]
497978006269	MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886
497978006270	MPT binding site; other site
497978006271	trimer interface [polypeptide binding]; other site
497978006272	MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756
497978006273	MoaE homodimer interface [polypeptide binding]; other site
497978006274	MoaD interaction [polypeptide binding]; other site
497978006275	active site residues [active]
497978006276	molybdenum cofactor biosynthesis protein A, bacterial; Region: moaA; TIGR02666
497978006277	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
497978006278	FeS/SAM binding site; other site
497978006279	Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463
497978006280	Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243
497978006281	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
497978006282	molybdopterin cofactor binding site; other site
497978006283	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
497978006284	The MopB_CT_1 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. This CD is of the...; Region: MopB_CT_1; cd02782
497978006285	putative molybdopterin cofactor binding site; other site
497978006286	molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317
497978006287	MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503
497978006288	GTP binding site; other site
497978006289	Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243
497978006290	Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754
497978006291	[4Fe-4S] binding site [ion binding]; other site
497978006292	molybdopterin cofactor binding site; other site
497978006293	Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791
497978006294	molybdopterin cofactor binding site; other site
497978006295	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
497978006296	Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529
497978006297	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992
497978006298	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
497978006299	nitrite reductase subunit NirD; Provisional; Region: PRK14989
497978006300	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
497978006301	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
497978006302	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
497978006303	Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707
497978006304	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
497978006305	active site
497978006306	phosphorylation site [posttranslational modification]
497978006307	intermolecular recognition site; other site
497978006308	dimerization interface [polypeptide binding]; other site
497978006309	ANTAR domain; Region: ANTAR; pfam03861
497978006310	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
497978006311	NMT1-like family; Region: NMT1_2; pfam13379
497978006312	DNA polymerase V subunit UmuC; Reviewed; Region: umuC; PRK03609
497978006313	umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700
497978006314	active site
497978006315	DNA binding site [nucleotide binding]
497978006316	Domain of unknown function (DUF4113); Region: DUF4113; pfam13438
497978006317	Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466
497978006318	Dehydroquinase class II; Region: DHquinase_II; pfam01220
497978006319	trimer interface [polypeptide binding]; other site
497978006320	active site
497978006321	dimer interface [polypeptide binding]; other site
497978006322	acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302
497978006323	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
497978006324	carboxyltransferase (CT) interaction site; other site
497978006325	biotinylation site [posttranslational modification]; other site
497978006326	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
497978006327	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
497978006328	ATP-grasp domain; Region: ATP-grasp_4; cl17255
497978006329	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
497978006330	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
497978006331	putative 3-phenylpropionic acid transporter; Provisional; Region: PRK11128
497978006332	putative substrate translocation pore; other site
497978006333	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
497978006334	Transposase; Region: HTH_Tnp_1; pfam01527
497978006335	putative transposase OrfB; Reviewed; Region: PHA02517
497978006336	HTH-like domain; Region: HTH_21; pfam13276
497978006337	Integrase core domain; Region: rve; pfam00665
497978006338	Integrase core domain; Region: rve_3; pfam13683
497978006339	Glycosyl hydrolase 108; Region: Glyco_hydro_108; pfam05838
497978006340	Predicted Peptidoglycan domain; Region: PG_binding_3; pfam09374
497978006341	Domain of unknown function (DUF1833); Region: DUF1833; pfam08875
497978006342	Phage-related minor tail protein [Function unknown]; Region: COG5281
497978006343	tape measure domain; Region: tape_meas_nterm; TIGR02675
497978006344	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
497978006345	Peptidase family M23; Region: Peptidase_M23; pfam01551
497978006346	KilA-N domain; Region: KilA-N; pfam04383
497978006347	Mnt; Region: mnt; PHA01513
497978006348	Arc-like DNA binding domain; Region: Arc; pfam03869
497978006349	Protein of unknown function (DUF4236); Region: DUF4236; pfam14020
497978006350	hypothetical protein; Provisional; Region: PRK10040
497978006351	Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681
497978006352	Uncharacterized protein family (UPF0156); Region: RHH_2; cl17383
497978006353	YcfA-like protein; Region: YcfA; pfam07927
497978006354	Bacteriophage related domain of unknown function; Region: DUF4128; pfam13554
497978006355	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
497978006356	LEM-like domain of lamina-associated polypeptide 2 (LAP2) and similar proteins; Region: LEM_like; cd12935
497978006357	phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554
497978006358	Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072
497978006359	Domain of unknown function (DUF4055); Region: DUF4055; pfam13264
497978006360	Terminase-like family; Region: Terminase_6; pfam03237
497978006361	3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; cl00311
497978006362	Uncharacterized conserved protein (DUF2280); Region: DUF2280; cl02353
497978006363	Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277
497978006364	putative active site [active]
497978006365	Protein of unknown function (DUF1376); Region: DUF1376; pfam07120
497978006366	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
497978006367	non-specific DNA binding site [nucleotide binding]; other site
497978006368	salt bridge; other site
497978006369	Predicted transcriptional regulator [Transcription]; Region: COG2932
497978006370	sequence-specific DNA binding site [nucleotide binding]; other site
497978006371	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
497978006372	Catalytic site [active]
497978006373	AAA domain; Region: AAA_24; pfam13479
497978006374	phage nucleotide-binding protein; Region: phage_P_loop; TIGR01618
497978006375	Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267
497978006376	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
497978006377	Uncharacterized conserved protein [Function unknown]; Region: COG1434
497978006378	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
497978006379	putative active site [active]
497978006380	UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK00046
497978006381	FAD binding domain; Region: FAD_binding_4; pfam01565
497978006382	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873
497978006383	Low molecular weight phosphatase family; Region: LMWPc; cd00115
497978006384	Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451
497978006385	active site
497978006386	Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282
497978006387	Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454
497978006388	5-hydroxyvalerate dehydrogenase (HVD) catalyzes the oxidation of 5-hydroxyvalerate to 5-oxovalerate with NAD+ as cofactor; Region: HVD; cd08193
497978006389	putative active site [active]
497978006390	metal binding site [ion binding]; metal-binding site
497978006391	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
497978006392	active site
497978006393	phospholipase C, phosphocholine-specific, Pseudomonas-type; Region: PC_PLC; TIGR03396
497978006394	Phosphoesterase family; Region: Phosphoesterase; pfam04185
497978006395	Domain of unknown function (DUF756); Region: DUF756; pfam05506
497978006396	Domain of unknown function (DUF756); Region: DUF756; pfam05506
497978006397	DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14960
497978006398	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
497978006399	Walker A motif; other site
497978006400	ATP binding site [chemical binding]; other site
497978006401	Walker B motif; other site
497978006402	arginine finger; other site
497978006403	DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169
497978006404	methyl viologen resistance protein SmvA; Provisional; Region: PRK14995
497978006405	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
497978006406	putative substrate translocation pore; other site
497978006407	TetR family transcriptional regulator; Provisional; Region: PRK14996
497978006408	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
497978006409	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
497978006410	Beta-lactamase; Region: Beta-lactamase; pfam00144
497978006411	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
497978006412	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
497978006413	active site 2 [active]
497978006414	active site 1 [active]
497978006415	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08261
497978006416	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
497978006417	NAD(P) binding site [chemical binding]; other site
497978006418	active site
497978006419	acetyl-CoA acetyltransferase; Provisional; Region: PRK09268
497978006420	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
497978006421	dimer interface [polypeptide binding]; other site
497978006422	active site
497978006423	Bacterial Transmembrane Pair family; Region: BTP; pfam05232
497978006424	Bacterial Transmembrane Pair family; Region: BTP; pfam05232
497978006425	Transcriptional regulator [Transcription]; Region: LysR; COG0583
497978006426	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
497978006427	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
497978006428	dimerization interface [polypeptide binding]; other site
497978006429	transaldolase-like protein; Provisional; Region: PTZ00411
497978006430	Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957
497978006431	active site
497978006432	dimer interface [polypeptide binding]; other site
497978006433	catalytic residue [active]
497978006434	leucine export protein LeuE; Provisional; Region: PRK10958
497978006435	leucine-responsive transcriptional regulator; Provisional; Region: PRK11169
497978006436	Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412
497978006437	AsnC family; Region: AsnC_trans_reg; pfam01037
497978006438	Benzoate membrane transport protein; Region: BenE; pfam03594
497978006439	benzoate transporter; Region: benE; TIGR00843
497978006440	Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285
497978006441	MgtC family; Region: MgtC; pfam02308
497978006442	magnesium-transporting ATPase MgtA; Provisional; Region: PRK10517
497978006443	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690
497978006444	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
497978006445	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
497978006446	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
497978006447	RDD family; Region: RDD; pfam06271
497978006448	dipeptidase, putative; Region: dipeptidaselike; TIGR01887
497978006449	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
497978006450	Ligand Binding Site [chemical binding]; other site
497978006451	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
497978006452	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
497978006453	Walker A/P-loop; other site
497978006454	ATP binding site [chemical binding]; other site
497978006455	Q-loop/lid; other site
497978006456	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
497978006457	ABC transporter signature motif; other site
497978006458	Walker B; other site
497978006459	D-loop; other site
497978006460	ABC transporter; Region: ABC_tran_2; pfam12848
497978006461	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
497978006462	Outer membrane protein W [Cell envelope biogenesis, outer membrane]; Region: OmpW; COG3047
497978006463	Outer membrane receptor for ferric coprogen and ferric-rhodotorulic acid [Inorganic ion transport and metabolism]; Region: FhuE; COG4773
497978006464	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
497978006465	N-terminal plug; other site
497978006466	ligand-binding site [chemical binding]; other site
497978006467	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
497978006468	synaptic vesicle protein SV2; Region: synapt_SV2; TIGR01299
497978006469	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
497978006470	Mechanosensitive ion channel; Region: MS_channel; pfam00924
497978006471	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
497978006472	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
497978006473	N-terminal plug; other site
497978006474	ligand-binding site [chemical binding]; other site
497978006475	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
497978006476	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
497978006477	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
497978006478	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
497978006479	putative DNA binding site [nucleotide binding]; other site
497978006480	putative Zn2+ binding site [ion binding]; other site
497978006481	AsnC family; Region: AsnC_trans_reg; pfam01037
497978006482	chorismate mutase; Provisional; Region: PRK08055
497978006483	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
497978006484	active site
497978006485	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
497978006486	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
497978006487	NAD(P) binding site [chemical binding]; other site
497978006488	active site
497978006489	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
497978006490	Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of  glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570
497978006491	C-terminal domain interface [polypeptide binding]; other site
497978006492	GSH binding site (G-site) [chemical binding]; other site
497978006493	dimer interface [polypeptide binding]; other site
497978006494	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299
497978006495	N-terminal domain interface [polypeptide binding]; other site
497978006496	aminopeptidase N; Provisional; Region: pepN; PRK14015
497978006497	Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_1; cd09600
497978006498	active site
497978006499	Zn binding site [ion binding]; other site
497978006500	4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170
497978006501	substrate binding site [chemical binding]; other site
497978006502	multimerization interface [polypeptide binding]; other site
497978006503	ATP binding site [chemical binding]; other site
497978006504	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
497978006505	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
497978006506	DNA gyrase inhibitor [DNA replication, recombination, and repair]; Region: COG3449
497978006507	5-carboxymethyl-2-hydroxymuconate isomerase (CHMI) is a trimeric enzyme catalyzing the isomerization of the unsaturated ketone 5-(carboxymethyl)-2-hydroxymuconate to 5-(carboxymethyl)-2-oxo-3-hexene-1,6-dionate. This is one step in the...; Region: CHMI; cd00580
497978006508	putative substrate binding pocket [chemical binding]; other site
497978006509	trimer interface [polypeptide binding]; other site
497978006510	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
497978006511	PIF1-like helicase; Region: PIF1; pfam05970
497978006512	Walker A motif; other site
497978006513	ATP binding site [chemical binding]; other site
497978006514	Walker B motif; other site
497978006515	Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176
497978006516	Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454
497978006517	dimer interface [polypeptide binding]; other site
497978006518	active site
497978006519	metal binding site [ion binding]; metal-binding site
497978006520	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
497978006521	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
497978006522	Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862
497978006523	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
497978006524	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
497978006525	NAD(P) binding site [chemical binding]; other site
497978006526	catalytic residues [active]
497978006527	ethanolamine permease; Region: 2A0305; TIGR00908
497978006528	ethanolamine ammonia lyase large subunit; Provisional; Region: PRK15067
497978006529	Ethanolamine ammonia lyase large subunit (EutB); Region: EutB; pfam06751
497978006530	ethanolamine ammonia-lyase small subunit; Provisional; Region: PRK05465
497978006531	GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518
497978006532	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741
497978006533	catalytic triad [active]
497978006534	glutaminyl-tRNA synthetase; Provisional; Region: PRK05347
497978006535	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
497978006536	active site
497978006537	HIGH motif; other site
497978006538	nucleotide binding site [chemical binding]; other site
497978006539	catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807
497978006540	KMSKS motif; other site
497978006541	tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950
497978006542	cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920
497978006543	substrate binding site [chemical binding]; other site
497978006544	Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398
497978006545	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
497978006546	putative active site [active]
497978006547	putative metal binding site [ion binding]; other site
497978006548	NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149
497978006549	dimer interface [polypeptide binding]; other site
497978006550	FMN binding site [chemical binding]; other site
497978006551	EamA-like transporter family; Region: EamA; pfam00892
497978006552	phosphonate utilization associated putative membrane protein; Region: phn_DUF6; TIGR03340
497978006553	bacterial Hfq-like; Region: Hfq; cd01716
497978006554	hexamer interface [polypeptide binding]; other site
497978006555	Sm1 motif; other site
497978006556	RNA binding site [nucleotide binding]; other site
497978006557	Sm2 motif; other site
497978006558	tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324
497978006559	tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091
497978006560	DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095
497978006561	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
497978006562	ATP binding site [chemical binding]; other site
497978006563	Mg2+ binding site [ion binding]; other site
497978006564	G-X-G motif; other site
497978006565	MutL_Trans_MutL: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to Escherichia coli MutL.  EcMutL belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family.  This transducer domain is homologous to the second...; Region: MutL_Trans_MutL; cd03482
497978006566	ATP binding site [chemical binding]; other site
497978006567	MutL C terminal dimerisation domain; Region: MutL_C; pfam08676
497978006568	Uncharacterized P-loop hydrolase UPF0079; Region: UPF0079; cl00520
497978006569	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
497978006570	Pseudouridine synthase, a subgroup of the RluA family; Region: PSRA_1; cd02558
497978006571	probable active site [active]
497978006572	RelB antitoxin; Region: RelB; cl01171
497978006573	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
497978006574	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
497978006575	RNA binding surface [nucleotide binding]; other site
497978006576	Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553
497978006577	active site
497978006578	uracil binding [chemical binding]; other site
497978006579	Protein of unknown function (DUF441); Region: DUF441; pfam04284
497978006580	Transcriptional regulator [Transcription]; Region: LysR; COG0583
497978006581	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
497978006582	The C-terminal substrate binding domain of LysR-type transcriptional regulator metR, which regulates the expression of methionine biosynthetic genes, contains type 2 periplasmic binding fold; Region: PBP2_MetR; cd08441
497978006583	putative dimerization interface [polypeptide binding]; other site
497978006584	Domain of unknown function (DUF4198); Region: DUF4198; pfam10670
497978006585	conjugal transfer nickase/helicase TraI; Provisional; Region: PRK14712
497978006586	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
497978006587	Major Facilitator Superfamily; Region: MFS_1; pfam07690
497978006588	putative substrate translocation pore; other site
497978006589	Ion transport protein; Region: Ion_trans; pfam00520
497978006590	Ion channel; Region: Ion_trans_2; pfam07885
497978006591	CCC1-related family of proteins; Region: CCC1_like; cl00278
497978006592	bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238
497978006593	Aconitase B swivel domain. Aconitate hydratase B is involved in energy metabolism as part of the TCA cycle. It catalyses the formation of cis-aconitate from citrate. This is the aconitase swivel domain, which undergoes swivelling conformational change in...; Region: AcnB_Swivel; cd01576
497978006594	substrate binding site [chemical binding]; other site
497978006595	Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle; Region: AcnB; cd01581
497978006596	substrate binding site [chemical binding]; other site
497978006597	ligand binding site [chemical binding]; other site
497978006598	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911
497978006599	Family of unknown function (DUF490); Region: DUF490; pfam04357
497978006600	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
497978006601	Membrane-fusion protein [Cell envelope biogenesis, outer membrane]; Region: AcrA; COG0845
497978006602	Surface antigen; Region: Bac_surface_Ag; pfam01103
497978006603	lysophospholipid transporter LplT; Provisional; Region: PRK11195
497978006604	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
497978006605	putative substrate translocation pore; other site
497978006606	Demethoxyubiquinone hydroxylase, ferritin-like diiron-binding domain; Region: DMQH; cd01042
497978006607	diiron binding motif [ion binding]; other site
497978006608	Protein of unknown function (DUF2799); Region: DUF2799; pfam10973
497978006609	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
497978006610	Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174
497978006611	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
497978006612	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
497978006613	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
497978006614	active site
497978006615	phosphorylation site [posttranslational modification]
497978006616	intermolecular recognition site; other site
497978006617	dimerization interface [polypeptide binding]; other site
497978006618	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
497978006619	DNA binding site [nucleotide binding]
497978006620	Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205
497978006621	Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702
497978006622	USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987
497978006623	Ligand Binding Site [chemical binding]; other site
497978006624	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
497978006625	dimer interface [polypeptide binding]; other site
497978006626	phosphorylation site [posttranslational modification]
497978006627	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
497978006628	ATP binding site [chemical binding]; other site
497978006629	Mg2+ binding site [ion binding]; other site
497978006630	G-X-G motif; other site
497978006631	potassium-transporting ATPase subunit C; Reviewed; Region: PRK00315
497978006632	potassium-transporting ATPase subunit B; Provisional; Region: PRK01122
497978006633	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
497978006634	Soluble P-type ATPase [General function prediction only]; Region: COG4087
497978006635	potassium-transporting ATPase subunit A; Provisional; Region: PRK05482
497978006636	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cl00233
497978006637	catalytic center binding site [active]
497978006638	ATP binding site [chemical binding]; other site
497978006639	Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534
497978006640	homooctamer interface [polypeptide binding]; other site
497978006641	active site
497978006642	2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982
497978006643	ABC1 family; Region: ABC1; cl17513
497978006644	molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690
497978006645	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
497978006646	ATP binding site [chemical binding]; other site
497978006647	substrate interface [chemical binding]; other site
497978006648	Flavin reductase like domain; Region: Flavin_Reduct; smart00903
497978006649	Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365
497978006650	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
497978006651	acyl-activating enzyme (AAE) consensus motif; other site
497978006652	AMP binding site [chemical binding]; other site
497978006653	active site
497978006654	CoA binding site [chemical binding]; other site
497978006655	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
497978006656	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
497978006657	active site
497978006658	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08217
497978006659	17hydroxysteroid dehydrogenase type 10 (HSD10)-like, classical (c) SDRs; Region: HSD10-like_SDR_c; cd05371
497978006660	NAD binding site [chemical binding]; other site
497978006661	homodimer interface [polypeptide binding]; other site
497978006662	homotetramer interface [polypeptide binding]; other site
497978006663	active site
497978006664	Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625
497978006665	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
497978006666	SurA N-terminal domain; Region: SurA_N; pfam09312
497978006667	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
497978006668	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
497978006669	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
497978006670	substrate binding pocket [chemical binding]; other site
497978006671	ABC transporter periplasmic binding protein, urea carboxylase region; Region: ABC_peri_uca; TIGR03427
497978006672	membrane-bound complex binding site; other site
497978006673	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
497978006674	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
497978006675	ABC-ATPase subunit interface; other site
497978006676	N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328
497978006677	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
497978006678	peptide chain release factor 1; Validated; Region: prfA; PRK00591
497978006679	This domain is found in peptide chain release factors; Region: PCRF; smart00937
497978006680	RF-1 domain; Region: RF-1; pfam00472
497978006681	Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693
497978006682	Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141
497978006683	potential catalytic triad [active]
497978006684	conserved cys residue [active]
497978006685	Transcriptional regulator [Transcription]; Region: LysR; COG0583
497978006686	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
497978006687	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
497978006688	putative effector binding pocket; other site
497978006689	dimerization interface [polypeptide binding]; other site
497978006690	luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558
497978006691	probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858
497978006692	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
497978006693	PgaD-like protein; Region: PgaD; pfam13994
497978006694	N-glycosyltransferase; Provisional; Region: PRK11204
497978006695	CESA_like is  the cellulose synthase superfamily; Region: CESA_like; cd06423
497978006696	DXD motif; other site
497978006697	poly-beta-1,6-N-acetyl-D-glucosamine N-deacetylase PgaB; Region: deacetyl_PgaB; TIGR03938
497978006698	N-terminal putative catalytic polysaccharide deacetylase domain of bacterial poly-beta-1,6-N-acetyl-D-glucosamine N-deacetylase PgaB, and similar proteins; Region: CE4_PgaB_5s; cd10964
497978006699	putative active site [active]
497978006700	putative metal binding site [ion binding]; other site
497978006701	poly-beta-1,6 N-acetyl-D-glucosamine export porin PgaA; Region: PGA_TPR_OMP; TIGR03939
497978006702	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
497978006703	binding surface
497978006704	TPR motif; other site
497978006705	PEP synthetase regulatory protein; Provisional; Region: PRK05339
497978006706	phosphoenolpyruvate synthase; Validated; Region: PRK06464
497978006707	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
497978006708	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
497978006709	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
497978006710	Domain of unknown function (DUF4339); Region: DUF4339; pfam14237
497978006711	RDD family; Region: RDD; pfam06271
497978006712	cytochrome o ubiquinol oxidase subunit II; Region: CyoA; TIGR01433
497978006713	COX Aromatic Rich Motif; Region: COX_ARM; pfam06481
497978006714	Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843
497978006715	Ubiquinol oxidase subunit I.  Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane.  It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662
497978006716	D-pathway; other site
497978006717	Putative ubiquinol binding site [chemical binding]; other site
497978006718	Low-spin heme (heme b) binding site [chemical binding]; other site
497978006719	Putative water exit pathway; other site
497978006720	Binuclear center (heme o3/CuB) [ion binding]; other site
497978006721	K-pathway; other site
497978006722	Putative proton exit pathway; other site
497978006723	Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane.  It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863
497978006724	Subunit I/III interface [polypeptide binding]; other site
497978006725	Subunit III/IV interface [polypeptide binding]; other site
497978006726	cytochrome o ubiquinol oxidase subunit IV; Provisional; Region: PRK10582
497978006727	protoheme IX farnesyltransferase; Provisional; Region: PRK04375
497978006728	UbiA prenyltransferase family; Region: UbiA; pfam01040
497978006729	30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453
497978006730	30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391
497978006731	50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137
497978006732	Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281
497978006733	Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948
497978006734	replicative DNA helicase; Region: DnaB; TIGR00665
497978006735	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
497978006736	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
497978006737	Walker A motif; other site
497978006738	ATP binding site [chemical binding]; other site
497978006739	Walker B motif; other site
497978006740	DNA binding loops [nucleotide binding]
497978006741	alanine racemase; Reviewed; Region: alr; PRK00053
497978006742	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827
497978006743	active site
497978006744	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
497978006745	substrate binding site [chemical binding]; other site
497978006746	catalytic residues [active]
497978006747	dimer interface [polypeptide binding]; other site
497978006748	Predicted proteasome-type protease [Posttranslational modification, protein turnover, chaperones]; Region: COG3484
497978006749	Bacterial proteasome, beta subunit. The 20S proteasome, multisubunit proteolytic complex, is the central enzyme of nonlysosomal protein degradation in both the cytosol and nucleus. It is composed of 28 subunits arranged as four homoheptameric rings that...; Region: proteasome_beta_bacterial; cd03765
497978006750	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
497978006751	Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379
497978006752	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
497978006753	A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168
497978006754	Uncharacterized conserved protein [Function unknown]; Region: COG2308
497978006755	Predicted transcriptional regulator [Transcription]; Region: COG2378
497978006756	WYL domain; Region: WYL; pfam13280
497978006757	tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192
497978006758	NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206
497978006759	GidA associated domain 3; Region: GIDA_assoc_3; pfam13932
497978006760	Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325
497978006761	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
497978006762	S-adenosylmethionine binding site [chemical binding]; other site
497978006763	MJ0042 family finger-like domain; Region: MJ0042_CXXC; TIGR02098
497978006764	Protein of unknown function (DUF3426); Region: DUF3426; pfam11906
497978006765	Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420
497978006766	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881
497978006767	Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal  ATIC formylase domain that formylates...; Region: IMPCH; cd01421
497978006768	purine monophosphate binding site [chemical binding]; other site
497978006769	dimer interface [polypeptide binding]; other site
497978006770	putative catalytic residues [active]
497978006771	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798
497978006772	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362
497978006773	phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885
497978006774	Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844
497978006775	Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071
497978006776	Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843
497978006777	ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464
497978006778	NLPA lipoprotein; Region: Lipoprotein_9; pfam03180
497978006779	DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153
497978006780	ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258
497978006781	Walker A/P-loop; other site
497978006782	ATP binding site [chemical binding]; other site
497978006783	Q-loop/lid; other site
497978006784	ABC transporter signature motif; other site
497978006785	Walker B; other site
497978006786	D-loop; other site
497978006787	H-loop/switch region; other site
497978006788	NIL domain; Region: NIL; pfam09383
497978006789	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
497978006790	dimer interface [polypeptide binding]; other site
497978006791	conserved gate region; other site
497978006792	ABC-ATPase subunit interface; other site
497978006793	hydroxyacylglutathione hydrolase; Region: GSH_gloB; TIGR03413
497978006794	C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663
497978006795	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
497978006796	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
497978006797	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
497978006798	Major Facilitator Superfamily; Region: MFS_1; pfam07690
497978006799	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl17904
497978006800	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316
497978006801	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
497978006802	Integrase core domain; Region: rve; pfam00665
497978006803	Na+/glutamate symporter [Amino acid transport and metabolism]; Region: GltS; COG0786
497978006804	Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167
497978006805	alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561
497978006806	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
497978006807	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
497978006808	Helix-turn-helix domain; Region: HTH_18; pfam12833
497978006809	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
497978006810	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
497978006811	Sensors of blue-light using FAD; Region: BLUF; pfam04940
497978006812	Bacterial OB fold (BOF) protein; Region: BOF; cl01196
497978006813	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
497978006814	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
497978006815	active site
497978006816	Methyltransferase domain; Region: Methyltransf_31; pfam13847
497978006817	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
497978006818	S-adenosylmethionine binding site [chemical binding]; other site
497978006819	GlcNAc-PI de-N-acetylase; Region: PIG-L; pfam02585
497978006820	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
497978006821	active site
497978006822	Uncharacterized protein conserved in bacteria (DUF2171); Region: DUF2171; pfam09939
497978006823	gamma-aminobutyrate permease; Region: GABAperm; TIGR01773
497978006824	Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085
497978006825	methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722
497978006826	tetrameric interface [polypeptide binding]; other site
497978006827	NAD binding site [chemical binding]; other site
497978006828	catalytic residues [active]
497978006829	beta alanine--pyruvate transaminase; Provisional; Region: PRK09221
497978006830	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
497978006831	inhibitor-cofactor binding pocket; inhibition site
497978006832	pyridoxal 5'-phosphate binding site [chemical binding]; other site
497978006833	catalytic residue [active]
497978006834	Transcriptional regulator [Transcription]; Region: LysR; COG0583
497978006835	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
497978006836	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
497978006837	dimerization interface [polypeptide binding]; other site
497978006838	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
497978006839	substrate binding site [chemical binding]; other site
497978006840	activation loop (A-loop); other site
497978006841	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
497978006842	Domain of unknown function (DUF3336); Region: DUF3336; pfam11815
497978006843	Triacylglycerol lipase 3, 4, and 5 and Sugar-Dependent 1 lipase; Region: Pat_TGL3-4-5_SDP1; cd07206
497978006844	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752
497978006845	active site
497978006846	nucleophile elbow; other site
497978006847	Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG2607
497978006848	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
497978006849	Walker A motif; other site
497978006850	ATP binding site [chemical binding]; other site
497978006851	Walker B motif; other site
497978006852	UGMP family protein; Validated; Region: PRK09604
497978006853	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
497978006854	30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270
497978006855	Yqey-like protein; Region: YqeY; pfam09424
497978006856	Putative Zn-dependent protease, contains TPR repeats [General function prediction only]; Region: COG4783
497978006857	Peptidase family M48; Region: Peptidase_M48; cl12018
497978006858	bifunctional glyoxylate/hydroxypyruvate reductase B; Provisional; Region: PRK15409
497978006859	D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301
497978006860	dimerization interface [polypeptide binding]; other site
497978006861	ligand binding site [chemical binding]; other site
497978006862	NADP binding site [chemical binding]; other site
497978006863	catalytic site [active]
497978006864	Peptidase family M48; Region: Peptidase_M48; cl12018
497978006865	amidophosphoribosyltransferase; Provisional; Region: PRK09246
497978006866	Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of  glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715
497978006867	active site
497978006868	tetramer interface [polypeptide binding]; other site
497978006869	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
497978006870	active site
497978006871	Colicin V production protein; Region: Colicin_V; pfam02674
497978006872	dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286
497978006873	Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738
497978006874	quinone interaction residues [chemical binding]; other site
497978006875	active site
497978006876	catalytic residues [active]
497978006877	FMN binding site [chemical binding]; other site
497978006878	substrate binding site [chemical binding]; other site
497978006879	Type II secretion system (T2SS), protein M; Region: T2SM; cl01222
497978006880	Type II secretion system (T2SS), protein L; Region: T2SL; pfam05134
497978006881	GspL periplasmic domain; Region: GspL_C; cl14909
497978006882	Glycosyl hydrolase 108; Region: Glyco_hydro_108; pfam05838
497978006883	Predicted Peptidoglycan domain; Region: PG_binding_3; pfam09374
497978006884	Protein of unknown function (DUF2612); Region: DUF2612; pfam11041
497978006885	Baseplate J-like protein; Region: Baseplate_J; cl01294
497978006886	Protein of unknown function (DUF1311); Region: DUF1311; pfam07007
497978006887	phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760
497978006888	Protein of unknown function (DUF3277); Region: DUF3277; pfam11681
497978006889	Protein of unknown function (DUF3383); Region: DUF3383; pfam11863
497978006890	Protein of unknown function (DUF4054); Region: DUF4054; pfam13262
497978006891	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4834
497978006892	Uncharacterized protein conserved in bacteria (DUF2184); Region: DUF2184; pfam09950
497978006893	Uncharacterized protein conserved in bacteria (DUF2213); Region: DUF2213; pfam09979
497978006894	Uncharacterized small protein (DUF2158); Region: DUF2158; cl02293
497978006895	Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072
497978006896	phage-related protein, HI1409 family; Region: phge_rel_HI1409; TIGR01555
497978006897	Protein of unknown function (DUF1073); Region: DUF1073; pfam06381
497978006898	large terminase protein; Provisional; Region: 17; PHA02533
497978006899	Phage terminase large subunit; Region: Terminase_3; cl12054
497978006900	Uncharacterized conserved protein (DUF2280); Region: DUF2280; cl02353
497978006901	Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277
497978006902	putative active site [active]
497978006903	Protein of unknown function (DUF1376); Region: DUF1376; pfam07120
497978006904	DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863
497978006905	DNA methylase; Region: N6_N4_Mtase; pfam01555
497978006906	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
497978006907	non-specific DNA binding site [nucleotide binding]; other site
497978006908	salt bridge; other site
497978006909	sequence-specific DNA binding site [nucleotide binding]; other site
497978006910	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
497978006911	non-specific DNA binding site [nucleotide binding]; other site
497978006912	SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974
497978006913	salt bridge; other site
497978006914	sequence-specific DNA binding site [nucleotide binding]; other site
497978006915	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
497978006916	Catalytic site [active]
497978006917	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
497978006918	DNA N-6-adenine-methyltransferase (Dam); Region: Dam; cl05442
497978006919	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
497978006920	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
497978006921	active site
497978006922	DNA binding site [nucleotide binding]
497978006923	Int/Topo IB signature motif; other site
497978006924	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
497978006925	catalytic core [active]
497978006926	NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094
497978006927	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
497978006928	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
497978006929	Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135
497978006930	putative FMN binding site [chemical binding]; other site
497978006931	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
497978006932	DEAD-like helicases superfamily; Region: DEXDc; smart00487
497978006933	ATP binding site [chemical binding]; other site
497978006934	Mg++ binding site [ion binding]; other site
497978006935	motif III; other site
497978006936	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
497978006937	nucleotide binding region [chemical binding]; other site
497978006938	ATP-binding site [chemical binding]; other site
497978006939	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
497978006940	DNA-binding site [nucleotide binding]; DNA binding site
497978006941	RNA-binding motif; other site
497978006942	SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain.  SirA (also known as UvrY,  and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291
497978006943	CPxP  motif; other site
497978006944	RNA polymerase factor sigma-32; Reviewed; Region: PRK06596
497978006945	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
497978006946	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
497978006947	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
497978006948	DNA binding residues [nucleotide binding]
497978006949	Uncharacterized small membrane protein [Function unknown]; Region: COG2363
497978006950	ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565
497978006951	thiS-thiF/thiG interaction site; other site
497978006952	Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728
497978006953	ThiS interaction site; other site
497978006954	putative active site [active]
497978006955	tetramer interface [polypeptide binding]; other site
497978006956	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4339
497978006957	hypothetical protein; Validated; Region: PRK02101
497978006958	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2945
497978006959	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
497978006960	Xaa-His dipeptidase; Region: aa-his-dipept; TIGR01893
497978006961	M20 Peptidase D has specificity for beta-alanyl-L-histidine dipeptide; Region: M20_pepD; cd03890
497978006962	metal binding site [ion binding]; metal-binding site
497978006963	dimer interface [polypeptide binding]; other site
497978006964	bifunctional cyclohexadienyl dehydrogenase/ 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK14806
497978006965	prephenate dehydrogenase; Validated; Region: PRK08507
497978006966	EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556
497978006967	hinge; other site
497978006968	active site
497978006969	Chorismate mutase type II; Region: CM_2; cl00693
497978006970	Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077
497978006971	Prephenate dehydratase; Region: PDT; pfam00800
497978006972	C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905
497978006973	putative L-Phe binding site [chemical binding]; other site
497978006974	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819
497978006975	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
497978006976	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
497978006977	active site
497978006978	C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663
497978006979	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
497978006980	hypothetical protein; Validated; Region: PRK09071
497978006981	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
497978006982	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
497978006983	Protein of unknown function (DUF1315); Region: DUF1315; pfam07023
497978006984	inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK01231
497978006985	inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02231
497978006986	penicillin-binding protein 1B; Region: PBP_1b; TIGR02071
497978006987	Transglycosylase; Region: Transgly; pfam00912
497978006988	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
497978006989	hypothetical protein; Provisional; Region: PRK08999
497978006990	The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425
497978006991	active site
497978006992	8-oxo-dGMP binding site [chemical binding]; other site
497978006993	nudix motif; other site
497978006994	metal binding site [ion binding]; metal-binding site
497978006995	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
497978006996	thiamine phosphate binding site [chemical binding]; other site
497978006997	active site
497978006998	Hemin uptake protein hemP; Region: hemP; cl10043
497978006999	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
497978007000	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
497978007001	dimer interface [polypeptide binding]; other site
497978007002	phosphorylation site [posttranslational modification]
497978007003	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
497978007004	ATP binding site [chemical binding]; other site
497978007005	Mg2+ binding site [ion binding]; other site
497978007006	G-X-G motif; other site
497978007007	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
497978007008	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
497978007009	active site
497978007010	phosphorylation site [posttranslational modification]
497978007011	intermolecular recognition site; other site
497978007012	dimerization interface [polypeptide binding]; other site
497978007013	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
497978007014	DNA binding site [nucleotide binding]
497978007015	Bacterial OB fold (BOF) protein; Region: BOF; cl01196
497978007016	Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157
497978007017	Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804
497978007018	PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129
497978007019	Walker A motif; other site
497978007020	ATP binding site [chemical binding]; other site
497978007021	Walker B motif; other site
497978007022	Predicted membrane protein [Function unknown]; Region: COG3174
497978007023	Domain of unknown function (DUF4010); Region: DUF4010; pfam13194
497978007024	Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281
497978007025	homodimer interaction site [polypeptide binding]; other site
497978007026	cofactor binding site; other site
497978007027	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
497978007028	Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195
497978007029	FAD binding pocket [chemical binding]; other site
497978007030	FAD binding motif [chemical binding]; other site
497978007031	phosphate binding motif [ion binding]; other site
497978007032	beta-alpha-beta structure motif; other site
497978007033	NAD binding pocket [chemical binding]; other site
497978007034	Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384
497978007035	hydroxyproline-2-epimerase; Provisional; Region: PRK13971
497978007036	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
497978007037	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
497978007038	DNA-binding site [nucleotide binding]; DNA binding site
497978007039	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
497978007040	pyridoxal 5'-phosphate binding site [chemical binding]; other site
497978007041	homodimer interface [polypeptide binding]; other site
497978007042	catalytic residue [active]
497978007043	putative protease; Provisional; Region: PRK15452
497978007044	Peptidase family U32; Region: Peptidase_U32; pfam01136
497978007045	archaeoflavoprotein, MJ0208 family; Region: flavo_MJ0208; TIGR02700
497978007046	Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076
497978007047	ABC-type histidine transport system, ATPase component [Amino acid transport and metabolism]; Region: HisP; COG4598
497978007048	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
497978007049	Walker A/P-loop; other site
497978007050	ATP binding site [chemical binding]; other site
497978007051	Q-loop/lid; other site
497978007052	ABC transporter signature motif; other site
497978007053	Walker B; other site
497978007054	D-loop; other site
497978007055	H-loop/switch region; other site
497978007056	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
497978007057	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
497978007058	dimer interface [polypeptide binding]; other site
497978007059	conserved gate region; other site
497978007060	putative PBP binding loops; other site
497978007061	ABC-ATPase subunit interface; other site
497978007062	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
497978007063	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
497978007064	dimer interface [polypeptide binding]; other site
497978007065	conserved gate region; other site
497978007066	putative PBP binding loops; other site
497978007067	ABC-ATPase subunit interface; other site
497978007068	lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096
497978007069	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
497978007070	substrate binding pocket [chemical binding]; other site
497978007071	membrane-bound complex binding site; other site
497978007072	hinge residues; other site
497978007073	Transcriptional regulator [Transcription]; Region: LysR; COG0583
497978007074	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
497978007075	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472
497978007076	putative effector binding pocket; other site
497978007077	putative dimerization interface [polypeptide binding]; other site
497978007078	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
497978007079	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
497978007080	HlyD family secretion protein; Region: HlyD_3; pfam13437
497978007081	AcrB/AcrD/AcrF family; Region: ACR_tran; pfam00873
497978007082	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
497978007083	serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011
497978007084	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
497978007085	dimer interface [polypeptide binding]; other site
497978007086	active site
497978007087	glycine-pyridoxal phosphate binding site [chemical binding]; other site
497978007088	folate binding site [chemical binding]; other site
497978007089	Family of unknown function (DUF695); Region: DUF695; pfam05117
497978007090	Protein of unknown function (DUF1260); Region: DUF1260; pfam06877
497978007091	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
497978007092	Secretory lipase; Region: LIP; pfam03583
497978007093	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
497978007094	exodeoxyribonuclease X; Provisional; Region: PRK07983
497978007095	active site
497978007096	catalytic site [active]
497978007097	substrate binding site [chemical binding]; other site
497978007098	Protein of unknown function (DUF3820); Region: DUF3820; cl01411
497978007099	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
497978007100	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
497978007101	Walker A/P-loop; other site
497978007102	ATP binding site [chemical binding]; other site
497978007103	Q-loop/lid; other site
497978007104	ABC transporter signature motif; other site
497978007105	Walker B; other site
497978007106	D-loop; other site
497978007107	H-loop/switch region; other site
497978007108	inner membrane transport permease; Provisional; Region: PRK15066
497978007109	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
497978007110	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2904
497978007111	7-cyano-7-deazaguanine reductase; Provisional; Region: queF; PRK11792
497978007112	Enzyme related to GTP cyclohydrolase I [General function prediction only]; Region: COG0780
497978007113	rod shape-determining protein RodA; Region: rodA_shape; TIGR02210
497978007114	Transglycosylase SLT domain; Region: SLT_2; pfam13406
497978007115	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
497978007116	N-acetyl-D-glucosamine binding site [chemical binding]; other site
497978007117	catalytic residue [active]
497978007118	Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797
497978007119	Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330
497978007120	Protein of unknown function (DUF962); Region: DUF962; cl01879
497978007121	Branched-chain amino acid transport protein (AzlD); Region: AzlD; pfam05437
497978007122	Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296
497978007123	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
497978007124	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
497978007125	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
497978007126	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
497978007127	Protein of unknown function (DUF3465); Region: DUF3465; pfam11948
497978007128	elongation factor Ts; Provisional; Region: tsf; PRK09377
497978007129	UBA/TS-N domain; Region: UBA; pfam00627
497978007130	Elongation factor TS; Region: EF_TS; pfam00889
497978007131	Elongation factor TS; Region: EF_TS; pfam00889
497978007132	Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425
497978007133	rRNA interaction site [nucleotide binding]; other site
497978007134	S8 interaction site; other site
497978007135	putative laminin-1 binding site; other site
497978007136	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
497978007137	active site
497978007138	Outer membrane protein W [Cell envelope biogenesis, outer membrane]; Region: OmpW; COG3047
497978007139	nitrite extrusion protein (nitrite facilitator); Region: 2A0108; TIGR00886
497978007140	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
497978007141	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
497978007142	Major Facilitator Superfamily; Region: MFS_1; pfam07690
497978007143	putative substrate translocation pore; other site
497978007144	leucine-responsive transcriptional regulator; Provisional; Region: PRK11169
497978007145	soluble pyridine nucleotide transhydrogenase; Provisional; Region: PRK05249
497978007146	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
497978007147	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
497978007148	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
497978007149	lipoyl synthase; Provisional; Region: PRK05481
497978007150	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
497978007151	FeS/SAM binding site; other site
497978007152	acyl-CoA dehydrogenase; Reviewed; Region: fadE; PRK09463
497978007153	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
497978007154	active site
497978007155	Domain of unknown function (DUF1974); Region: DUF1974; pfam09317
497978007156	Carboxymuconolactone decarboxylase family; Region: CMD; cl00460
497978007157	Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296
497978007158	S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476
497978007159	S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401
497978007160	homotetramer interface [polypeptide binding]; other site
497978007161	ligand binding site [chemical binding]; other site
497978007162	catalytic site [active]
497978007163	NAD binding site [chemical binding]; other site
497978007164	Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537
497978007165	FAD binding site [chemical binding]; other site
497978007166	16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713
497978007167	RNA methyltransferase, RsmE family; Region: TIGR00046
497978007168	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
497978007169	PAS fold; Region: PAS_3; pfam08447
497978007170	heme pocket [chemical binding]; other site
497978007171	putative active site [active]
497978007172	PAS domain S-box; Region: sensory_box; TIGR00229
497978007173	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
497978007174	putative active site [active]
497978007175	heme pocket [chemical binding]; other site
497978007176	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
497978007177	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
497978007178	metal binding site [ion binding]; metal-binding site
497978007179	active site
497978007180	I-site; other site
497978007181	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
497978007182	bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed; Region: PRK07232
497978007183	Malic enzyme, N-terminal domain; Region: malic; pfam00390
497978007184	NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311
497978007185	putative NAD(P) binding site [chemical binding]; other site
497978007186	Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280
497978007187	multifunctional tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase; Reviewed; Region: cca; PRK10885
497978007188	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
497978007189	active site
497978007190	NTP binding site [chemical binding]; other site
497978007191	metal binding triad [ion binding]; metal-binding site
497978007192	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
497978007193	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
497978007194	Zn2+ binding site [ion binding]; other site
497978007195	Mg2+ binding site [ion binding]; other site
497978007196	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
497978007197	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
497978007198	protein binding site [polypeptide binding]; other site
497978007199	NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371
497978007200	Uncharacterized conserved protein [Function unknown]; Region: COG0327
497978007201	Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605
497978007202	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
497978007203	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
497978007204	Protein of unknown function (DUF2726); Region: DUF2726; pfam10881
497978007205	Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506
497978007206	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
497978007207	4-hydroxybenzoate octaprenyltransferase; Reviewed; Region: ubiA; PRK12848
497978007208	UbiA prenyltransferase family; Region: UbiA; pfam01040
497978007209	Chorismate lyase; Region: Chor_lyase; cl01230
497978007210	glutamine synthetase; Provisional; Region: glnA; PRK09469
497978007211	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
497978007212	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
497978007213	Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104
497978007214	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
497978007215	putative substrate translocation pore; other site
497978007216	POT family; Region: PTR2; cl17359
497978007217	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
497978007218	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
497978007219	X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP; cd01085
497978007220	active site
497978007221	para-aminobenzoate synthase component II; Provisional; Region: PRK08857
497978007222	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
497978007223	glutamine binding [chemical binding]; other site
497978007224	catalytic triad [active]
497978007225	Peptidase family M1; Region: Peptidase_M1; pfam01433
497978007226	Peptidase M1 Aminopeptidase N family incudes tricorn interacting factor F3, Endoplasmic reticulum aminopeptidase 1 (ERAP1), Aminopeptidase Q (APQ); Region: M1_APN_2; cd09601
497978007227	Zn binding site [ion binding]; other site
497978007228	Domain of unknown function (DUF3358); Region: DUF3358; pfam11838
497978007229	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
497978007230	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
497978007231	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
497978007232	anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188
497978007233	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
497978007234	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
497978007235	Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331
497978007236	active site
497978007237	ribulose/triose binding site [chemical binding]; other site
497978007238	phosphate binding site [ion binding]; other site
497978007239	substrate (anthranilate) binding pocket [chemical binding]; other site
497978007240	product (indole) binding pocket [chemical binding]; other site
497978007241	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2840
497978007242	Smr domain; Region: Smr; pfam01713
497978007243	XdhC and CoxI family; Region: XdhC_CoxI; pfam02625
497978007244	xanthine dehydrogenase accessory protein XdhC; Region: xanthine_xdhC; TIGR02964
497978007245	XdhC Rossmann domain; Region: XdhC_C; pfam13478
497978007246	xanthine dehydrogenase, molybdopterin binding subunit; Region: xanthine_xdhB; TIGR02965
497978007247	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
497978007248	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
497978007249	xanthine dehydrogenase, small subunit; Region: xanthine_xdhA; TIGR02963
497978007250	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085
497978007251	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
497978007252	CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450
497978007253	GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate.  The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria.  In...; Region: GTP_cyclohydro1; cd00642
497978007254	homodecamer interface [polypeptide binding]; other site
497978007255	GTP cyclohydrolase I; Provisional; Region: PLN03044
497978007256	active site
497978007257	putative catalytic site residues [active]
497978007258	zinc binding site [ion binding]; other site
497978007259	GTP-CH-I/GFRP interaction surface; other site
497978007260	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
497978007261	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
497978007262	beta-lactamase/D-alanine carboxypeptidase; Provisional; Region: ampC; PRK11289
497978007263	Domain of unknown function (DUF4105); Region: DUF4105; pfam13387
497978007264	Protein of unknown function (DUF3015); Region: DUF3015; pfam11220
497978007265	Protein of unknown function (DUF817); Region: DUF817; pfam05675
497978007266	Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717
497978007267	substrate binding site [chemical binding]; other site
497978007268	active site
497978007269	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
497978007270	Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409
497978007271	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
497978007272	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
497978007273	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
497978007274	4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648
497978007275	Thioesterase domain; Region: Thioesterase; pfam00975
497978007276	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
497978007277	putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608
497978007278	Walker A/P-loop; other site
497978007279	ATP binding site [chemical binding]; other site
497978007280	Q-loop/lid; other site
497978007281	ABC transporter signature motif; other site
497978007282	Walker B; other site
497978007283	D-loop; other site
497978007284	H-loop/switch region; other site
497978007285	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
497978007286	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
497978007287	Walker A/P-loop; other site
497978007288	ATP binding site [chemical binding]; other site
497978007289	Q-loop/lid; other site
497978007290	ABC transporter signature motif; other site
497978007291	Walker B; other site
497978007292	D-loop; other site
497978007293	H-loop/switch region; other site
497978007294	histidine decarboxylase; Provisional; Region: PRK02769
497978007295	Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155
497978007296	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
497978007297	catalytic residue [active]
497978007298	Isochorismatase, also known as 2,3 dihydro-2,3 dihydroxybenzoate synthase, catalyses the conversion of isochorismate, in the presence of water, to 2,3-dihydroxybenzoate and pyruvate, via the hydrolysis of a vinyl ether, an uncommon reaction in biological...; Region: isochorismatase; cd01013
497978007299	hydrophobic substrate binding pocket; other site
497978007300	Isochorismatase family; Region: Isochorismatase; pfam00857
497978007301	active site
497978007302	conserved cis-peptide bond; other site
497978007303	Aryl carrier domain [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3433
497978007304	enterobactin synthase subunit E; Provisional; Region: entE; PRK10946
497978007305	2,3-dihydroxybenzoate-AMP ligase; Region: 23DHB-AMP_lg; cd05920
497978007306	acyl-activating enzyme (AAE) consensus motif; other site
497978007307	active site
497978007308	AMP binding site [chemical binding]; other site
497978007309	substrate binding site [chemical binding]; other site
497978007310	Condensation domain; Region: Condensation; pfam00668
497978007311	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
497978007312	Nonribosomal peptide synthase; Region: NRPS; pfam08415
497978007313	Condensation domain; Region: Condensation; pfam00668
497978007314	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
497978007315	Nonribosomal peptide synthase; Region: NRPS; pfam08415
497978007316	Lysine/ornithine N-monooxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: IucD; COG3486
497978007317	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
497978007318	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
497978007319	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
497978007320	N-terminal plug; other site
497978007321	ligand-binding site [chemical binding]; other site
497978007322	ABC-type enterochelin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: CeuA; COG4607
497978007323	Siderophore binding protein FatB.  These proteins have been shown to function as ABC-type initial receptors in the siderophore-mediated iron uptake in some eubacterial species.  They belong to the TroA superfamily of periplasmic metal binding proteins...; Region: FatB; cd01140
497978007324	putative ligand binding residues [chemical binding]; other site
497978007325	ABC-type enterochelin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CeuD; COG4604
497978007326	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
497978007327	Walker A/P-loop; other site
497978007328	ATP binding site [chemical binding]; other site
497978007329	Q-loop/lid; other site
497978007330	ABC transporter signature motif; other site
497978007331	Walker B; other site
497978007332	D-loop; other site
497978007333	H-loop/switch region; other site
497978007334	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
497978007335	ABC-ATPase subunit  interface; other site
497978007336	dimer interface [polypeptide binding]; other site
497978007337	putative PBP binding regions; other site
497978007338	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
497978007339	ABC-ATPase subunit  interface; other site
497978007340	dimer interface [polypeptide binding]; other site
497978007341	putative PBP binding regions; other site
497978007342	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
497978007343	Condensation domain; Region: Condensation; pfam00668
497978007344	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
497978007345	The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; Region: A_NRPS_TlmIV_like; cd12114
497978007346	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
497978007347	acyl-activating enzyme (AAE) consensus motif; other site
497978007348	AMP binding site [chemical binding]; other site
497978007349	Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375
497978007350	Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193
497978007351	FAD binding pocket [chemical binding]; other site
497978007352	FAD binding motif [chemical binding]; other site
497978007353	phosphate binding motif [ion binding]; other site
497978007354	NAD binding pocket [chemical binding]; other site
497978007355	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964
497978007356	YheO-like PAS domain; Region: PAS_6; pfam08348
497978007357	HTH domain; Region: HTH_22; pfam13309
497978007358	Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342
497978007359	catalytic residue [active]
497978007360	Pirin-related protein [General function prediction only]; Region: COG1741
497978007361	Pirin; Region: Pirin; pfam02678
497978007362	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
497978007363	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
497978007364	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
497978007365	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
497978007366	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
497978007367	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
497978007368	Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR9; cd08274
497978007369	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
497978007370	putative NAD(P) binding site [chemical binding]; other site
497978007371	L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948
497978007372	Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188
497978007373	metal binding site [ion binding]; metal-binding site
497978007374	substrate binding pocket [chemical binding]; other site
497978007375	Sugar (and other) transporter; Region: Sugar_tr; pfam00083
497978007376	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
497978007377	putative substrate translocation pore; other site
497978007378	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
497978007379	Antitoxin of toxin-antitoxin stability system N-terminal; Region: RelB_N; pfam12910
497978007380	EamA-like transporter family; Region: EamA; pfam00892
497978007381	EamA-like transporter family; Region: EamA; pfam00892
497978007382	aromatic amino acid exporter; Provisional; Region: PRK11689
497978007383	Multiple antibiotic transporter [Intracellular trafficking and secretion]; Region: MarC; COG2095
497978007384	ethanolamine utilization protein EutQ; Provisional; Region: PRK15457
497978007385	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
497978007386	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
497978007387	Rubredoxin [Energy production and conversion]; Region: COG1773
497978007388	Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730
497978007389	iron binding site [ion binding]; other site
497978007390	NADH:flavorubredoxin oxidoreductase; Provisional; Region: PRK04965
497978007391	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
497978007392	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
497978007393	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
497978007394	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
497978007395	NAD(P) binding site [chemical binding]; other site
497978007396	catalytic residues [active]
497978007397	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
497978007398	Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469
497978007399	[2Fe-2S] cluster binding site [ion binding]; other site
497978007400	C-terminal catalytic domain of the oxygenase alpha subunit of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C; cd00680
497978007401	alpha subunit interface [polypeptide binding]; other site
497978007402	active site
497978007403	substrate binding site [chemical binding]; other site
497978007404	Fe binding site [ion binding]; other site
497978007405	BCCT family transporter; Region: BCCT; pfam02028
497978007406	BCCT family transporter; Region: BCCT; pfam02028
497978007407	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
497978007408	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
497978007409	The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432
497978007410	dimerization interface [polypeptide binding]; other site
497978007411	substrate binding pocket [chemical binding]; other site
497978007412	HTH-like domain; Region: HTH_21; pfam13276
497978007413	DDE domain; Region: DDE_Tnp_IS240; pfam13610
497978007414	Integrase core domain; Region: rve; pfam00665
497978007415	Integrase core domain; Region: rve_3; pfam13683
497978007416	Transposase; Region: HTH_Tnp_1; cl17663
497978007417	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
497978007418	Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113
497978007419	Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085
497978007420	methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722
497978007421	tetrameric interface [polypeptide binding]; other site
497978007422	NAD binding site [chemical binding]; other site
497978007423	catalytic residues [active]
497978007424	Protein of unknown function (DUF861); Region: Cupin_3; pfam05899
497978007425	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
497978007426	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
497978007427	Purine catabolism regulatory protein-like family; Region: PucR; pfam07905
497978007428	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
497978007429	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
497978007430	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
497978007431	Phage antirepressor protein KilAC domain; Region: ANT; cl01462
497978007432	Protein of unknown function (DUF466); Region: DUF466; pfam04328
497978007433	carbon starvation protein A; Provisional; Region: PRK15015
497978007434	Carbon starvation protein CstA; Region: CstA; pfam02554
497978007435	C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722
497978007436	elongation factor P; Validated; Region: PRK00529
497978007437	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
497978007438	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
497978007439	RNA binding site [nucleotide binding]; other site
497978007440	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
497978007441	RNA binding site [nucleotide binding]; other site
497978007442	Radical SAM superfamily; Region: Radical_SAM; pfam04055
497978007443	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
497978007444	FeS/SAM binding site; other site
497978007445	Mor transcription activator family; Region: Mor; cl02360
497978007446	Protein of unknown function (DUF1018); Region: DUF1018; pfam06252
497978007447	Protein of unknown function (DUF2786); Region: DUF2786; pfam10979
497978007448	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
497978007449	IHF dimer interface [polypeptide binding]; other site
497978007450	IHF - DNA interface [nucleotide binding]; other site
497978007451	Bacteriophage Mu Gam like protein; Region: Phage_Mu_Gam; pfam07352
497978007452	Protein of unknown function (DUF2752); Region: DUF2752; pfam10825
497978007453	Animal heme peroxidases and related proteins; Region: An_peroxidase_like; cl14561
497978007454	phage/conjugal plasmid C-4 type zinc finger protein, TraR family; Region: C4_traR_proteo; TIGR02419
497978007455	Type II secretory pathway, component ExeA (predicted ATPase) [Intracellular trafficking and secretion]; Region: ExeA; COG3267
497978007456	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
497978007457	Walker A/P-loop; other site
497978007458	ATP binding site [chemical binding]; other site
497978007459	Integrase core domain; Region: rve; pfam00665
497978007460	Protein of unknown function (DUF3102); Region: DUF3102; pfam11300
497978007461	MarR family; Region: MarR_2; cl17246
497978007462	phage-associated protein, BcepMu gp16 family; Region: BcepMu_gp16; TIGR04111
497978007463	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
497978007464	non-specific DNA binding site [nucleotide binding]; other site
497978007465	salt bridge; other site
497978007466	sequence-specific DNA binding site [nucleotide binding]; other site
497978007467	Predicted transcriptional regulator [Transcription]; Region: COG2932
497978007468	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
497978007469	Catalytic site [active]
497978007470	Lysozyme family protein [General function prediction only]; Region: zliS; COG3926
497978007471	Glycosyl hydrolase 108; Region: Glyco_hydro_108; pfam05838
497978007472	Predicted Peptidoglycan domain; Region: PG_binding_3; pfam09374
497978007473	Putative Zn-dependent protease [General function prediction only]; Region: COG4784
497978007474	Protein of unknown function (DUF3486); Region: DUF3486; pfam11985
497978007475	Mu-like prophage FluMu protein gp28 [General function prediction only]; Region: COG4373
497978007476	Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dam; COG0338
497978007477	Protein of unknown function (DUF935); Region: DUF935; pfam06074
497978007478	Mu-like prophage protein gp29 [Function unknown]; Region: COG4383
497978007479	Uncharacterized protein, homolog of phage Mu protein gp30 [Function unknown]; Region: COG2369
497978007480	Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072
497978007481	Phage virion morphogenesis family; Region: Phage_tail_S; cl02089
497978007482	Mu-like prophage I protein; Region: Mu-like_Pro; pfam10123
497978007483	Mu-like prophage major head subunit gpT; Region: Mu-like_gpT; cl01826
497978007484	Mu-like prophage major head subunit gpT; Region: Mu-like_gpT; cl01826
497978007485	Mu-like prophage major head subunit gpT; Region: Mu-like_gpT; cl01826
497978007486	Protein of unknown function (DUF1320); Region: DUF1320; cl01818
497978007487	Domain of unknown function (DUF1834); Region: DUF1834; pfam08873
497978007488	Mu-like prophage tail sheath protein gpL [General function prediction only]; Region: COG4386
497978007489	Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cd00260
497978007490	catalytic site [active]
497978007491	Asp-box motif; other site
497978007492	Phage tail sheath protein; Region: Phage_sheath_1; cl01389
497978007493	Phage-related minor tail protein; Region: PhageMin_Tail; pfam10145
497978007494	Mu-like prophage DNA circulation protein [General function prediction only]; Region: COG4228
497978007495	DNA circulation protein N-terminus; Region: DNA_circ_N; pfam07157
497978007496	Mu-like prophage tail protein gpP [General function prediction only]; Region: COG4379
497978007497	Bacteriophage Mu Gp45 protein; Region: Phage_Mu_Gp45; cl15410
497978007498	Phage protein GP46; Region: GP46; cl01814
497978007499	Baseplate J-like protein; Region: Baseplate_J; cl01294
497978007500	Uncharacterized protein conserved in bacteria (DUF2313); Region: DUF2313; cl01542
497978007501	PAS domain S-box; Region: sensory_box; TIGR00229
497978007502	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cl00290
497978007503	50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019
497978007504	Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385
497978007505	SBF-like CPA transporter family (DUF4137); Region: DUF4137; pfam13593
497978007506	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
497978007507	Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233
497978007508	dimer interface [polypeptide binding]; other site
497978007509	active site
497978007510	metal binding site [ion binding]; metal-binding site
497978007511	glutathione binding site [chemical binding]; other site
497978007512	muropeptide transporter; Validated; Region: ampG; cl17669
497978007513	muropeptide transporter; Validated; Region: ampG; cl17669
497978007514	muropeptide transporter; Validated; Region: ampG; cl17669
497978007515	AAA domain; Region: AAA_32; pfam13654
497978007516	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cl00148
497978007517	primary dimer interface [polypeptide binding]; other site
497978007518	lon-related putative ATP-dependent protease; Region: lon_rel; TIGR00764
497978007519	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
497978007520	Transcriptional regulator [Transcription]; Region: LysR; COG0583
497978007521	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
497978007522	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
497978007523	putative effector binding pocket; other site
497978007524	dimerization interface [polypeptide binding]; other site
497978007525	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
497978007526	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
497978007527	Peptidase family M23; Region: Peptidase_M23; pfam01551
497978007528	5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346
497978007529	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
497978007530	D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686
497978007531	Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936
497978007532	Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663
497978007533	Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645
497978007534	trimer interface [polypeptide binding]; other site
497978007535	putative metal binding site [ion binding]; other site
497978007536	Contains a crystal structure of the Nudix hydrolase from Nitrosomonas europaea, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_2; cd03675
497978007537	nudix motif; other site
497978007538	Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482
497978007539	tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998
497978007540	putative lysogenization regulator; Reviewed; Region: PRK00218
497978007541	adenylosuccinate lyase; Provisional; Region: PRK09285
497978007542	PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598
497978007543	tetramer interface [polypeptide binding]; other site
497978007544	active site
497978007545	Predicted membrane protein (DUF2238); Region: DUF2238; pfam09997
497978007546	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
497978007547	signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706
497978007548	Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023
497978007549	tandem repeat interface [polypeptide binding]; other site
497978007550	oligomer interface [polypeptide binding]; other site
497978007551	active site residues [active]
497978007552	phosphate transporter ATP-binding protein; Provisional; Region: PRK14235
497978007553	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
497978007554	Walker A/P-loop; other site
497978007555	ATP binding site [chemical binding]; other site
497978007556	Q-loop/lid; other site
497978007557	ABC transporter signature motif; other site
497978007558	Walker B; other site
497978007559	D-loop; other site
497978007560	H-loop/switch region; other site
497978007561	Domain of unknown function (DUF3333); Region: DUF3333; pfam11812
497978007562	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581
497978007563	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
497978007564	dimer interface [polypeptide binding]; other site
497978007565	conserved gate region; other site
497978007566	putative PBP binding loops; other site
497978007567	ABC-ATPase subunit interface; other site
497978007568	Phosphate ATP-binding cassette transporter; Region: DUF3708; pfam12501
497978007569	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573
497978007570	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
497978007571	dimer interface [polypeptide binding]; other site
497978007572	conserved gate region; other site
497978007573	putative PBP binding loops; other site
497978007574	ABC-ATPase subunit interface; other site
497978007575	ABC-type phosphate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PstS; COG0226
497978007576	aromatic amino acid transporter; Provisional; Region: PRK10238
497978007577	Pyruvate decarboxylase and related thiamine pyrophosphate-requiring enzymes [Carbohydrate transport and metabolism / Coenzyme metabolism / General function prediction only]; Region: COG3961
497978007578	Pyrimidine (PYR) binding domain of pyruvate decarboxylase (PDC), indolepyruvate decarboxylase (IPDC) and related proteins; Region: TPP_PYR_PDC_IPDC_like; cd07038
497978007579	dimer interface [polypeptide binding]; other site
497978007580	PYR/PP interface [polypeptide binding]; other site
497978007581	TPP binding site [chemical binding]; other site
497978007582	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
497978007583	Thiamine pyrophosphate (TPP) family, PDC_IPDC subfamily, TPP-binding module; composed of proteins similar to pyruvate decarboxylase (PDC) and indolepyruvate decarboxylase (IPDC). PDC, a key enzyme in alcoholic fermentation, catalyzes the conversion of...; Region: TPP_PDC_IPDC; cd02005
497978007584	TPP-binding site [chemical binding]; other site
497978007585	dimer interface [polypeptide binding]; other site
497978007586	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
497978007587	AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404
497978007588	AsnC family; Region: AsnC_trans_reg; pfam01037
497978007589	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
497978007590	Streptomyces aureofaciens putative aldehyde dehydrogenase AldA (AAD23400)-like; Region: ALDH_AldA-AAD23400; cd07106
497978007591	NAD(P) binding site [chemical binding]; other site
497978007592	catalytic residues [active]
497978007593	DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450
497978007594	pyridoxal 5'-phosphate binding site [chemical binding]; other site
497978007595	catalytic residue [active]
497978007596	diaminobutyrate--2-oxoglutarate aminotransferase; Provisional; Region: PRK06931
497978007597	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
497978007598	inhibitor-cofactor binding pocket; inhibition site
497978007599	pyridoxal 5'-phosphate binding site [chemical binding]; other site
497978007600	catalytic residue [active]
497978007601	Protein of unknown function (DUF541); Region: SIMPL; cl01077
497978007602	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
497978007603	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
497978007604	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
497978007605	CoenzymeA binding site [chemical binding]; other site
497978007606	subunit interaction site [polypeptide binding]; other site
497978007607	PHB binding site; other site
497978007608	Fatty acid desaturase; Region: FA_desaturase; pfam00487
497978007609	The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506
497978007610	putative di-iron ligands [ion binding]; other site
497978007611	Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_2; cd06216
497978007612	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
497978007613	FAD binding pocket [chemical binding]; other site
497978007614	FAD binding motif [chemical binding]; other site
497978007615	phosphate binding motif [ion binding]; other site
497978007616	beta-alpha-beta structure motif; other site
497978007617	NAD binding pocket [chemical binding]; other site
497978007618	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
497978007619	catalytic loop [active]
497978007620	iron binding site [ion binding]; other site
497978007621	DNA-binding transcriptional repressor FabR; Provisional; Region: PRK11202
497978007622	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
497978007623	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465
497978007624	ATP-dependent helicase HepA; Validated; Region: PRK04914
497978007625	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
497978007626	ATP binding site [chemical binding]; other site
497978007627	putative Mg++ binding site [ion binding]; other site
497978007628	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
497978007629	nucleotide binding region [chemical binding]; other site
497978007630	ATP-binding site [chemical binding]; other site
497978007631	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
497978007632	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
497978007633	active site
497978007634	Phosphopantetheine attachment site; Region: PP-binding; cl09936
497978007635	glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062
497978007636	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
497978007637	inhibitor-cofactor binding pocket; inhibition site
497978007638	pyridoxal 5'-phosphate binding site [chemical binding]; other site
497978007639	catalytic residue [active]
497978007640	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
497978007641	thiamine phosphate binding site [chemical binding]; other site
497978007642	active site
497978007643	pyrophosphate binding site [ion binding]; other site
497978007644	Protein of unknown function (DUF962); Region: DUF962; pfam06127
497978007645	Uncharacterized conserved protein [Function unknown]; Region: COG3025
497978007646	Uncharacterized subgroup of the CYTH-like superfamily having an associated CHAD domain; Region: CYTH-like_Pase_CHAD; cd07756
497978007647	putative active site [active]
497978007648	putative metal binding residues [ion binding]; other site
497978007649	signature motif; other site
497978007650	putative triphosphate binding site [ion binding]; other site
497978007651	The CHAD domain is an alpha-helical domain functionally associated with some members of the adenylate cyclase family; Region: CHAD; smart00880
497978007652	Protein of unknown function (DUF3144); Region: DUF3144; pfam11342
497978007653	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
497978007654	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
497978007655	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
497978007656	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
497978007657	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
497978007658	Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384
497978007659	Predicted Na+/dicarboxylate symporter [General function prediction only]; Region: COG1823
497978007660	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
497978007661	Transcriptional regulator [Transcription]; Region: LysR; COG0583
497978007662	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
497978007663	The C-terminal substrate binding domain of LysR-type transcriptional regulators, YofA and SoxR, contains the type 2 periplasmic binding fold; Region: PBP2_YofA_SoxR_like; cd08442
497978007664	putative dimerization interface [polypeptide binding]; other site
497978007665	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
497978007666	Major Facilitator Superfamily; Region: MFS_1; pfam07690
497978007667	putative substrate translocation pore; other site
497978007668	isocitrate dehydrogenase; Validated; Region: PRK06451
497978007669	isocitrate dehydrogenase; Reviewed; Region: PRK07006
497978007670	Pseudouridine synthase, Escherichia coli RluE; Region: PseudoU_synth_RluE; cd02566
497978007671	pseudouridine synthase; Region: TIGR00093
497978007672	probable active site [active]
497978007673	Monomeric isocitrate dehydrogenase [Energy production and conversion]; Region: Icd; COG2838
497978007674	Monomeric isocitrate dehydrogenase; Region: IDH; cl15383
497978007675	Predicted protease with the C-terminal PDZ domain [General function prediction only]; Region: COG3975
497978007676	M61 glycyl aminopeptidase; Region: Peptidase_M61; pfam05299
497978007677	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
497978007678	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
497978007679	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768
497978007680	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
497978007681	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
497978007682	FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095
497978007683	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
497978007684	Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415
497978007685	DNA photolyase; Region: DNA_photolyase; pfam00875
497978007686	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
497978007687	IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717
497978007688	Modifier of rudimentary (Mod(r)) protein; Region: Mod_r; pfam07200
497978007689	Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007
497978007690	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
497978007691	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005
497978007692	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
497978007693	IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817
497978007694	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
497978007695	CESA_like is  the cellulose synthase superfamily; Region: CESA_like; cd06423
497978007696	DXD motif; other site
497978007697	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
497978007698	UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381
497978007699	Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase  family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786
497978007700	active site
497978007701	homodimer interface [polypeptide binding]; other site
497978007702	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
497978007703	TPR motif; other site
497978007704	binding surface
497978007705	Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_1; cd02432
497978007706	Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070
497978007707	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
497978007708	FMN binding site [chemical binding]; other site
497978007709	substrate binding site [chemical binding]; other site
497978007710	putative catalytic residue [active]
497978007711	putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737
497978007712	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
497978007713	FMN binding site [chemical binding]; other site
497978007714	active site
497978007715	catalytic residues [active]
497978007716	substrate binding site [chemical binding]; other site
497978007717	Protein of unknown function (DUF1615); Region: DUF1615; pfam07759
497978007718	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
497978007719	gamma-glutamyl kinase; Provisional; Region: PRK05429
497978007720	AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242
497978007721	nucleotide binding site [chemical binding]; other site
497978007722	homotetrameric interface [polypeptide binding]; other site
497978007723	putative phosphate binding site [ion binding]; other site
497978007724	putative allosteric binding site; other site
497978007725	PUA domain; Region: PUA; pfam01472
497978007726	GTPase CgtA; Reviewed; Region: obgE; PRK12298
497978007727	GTP1/OBG; Region: GTP1_OBG; pfam01018
497978007728	Obg GTPase; Region: Obg; cd01898
497978007729	G1 box; other site
497978007730	GTP/Mg2+ binding site [chemical binding]; other site
497978007731	Switch I region; other site
497978007732	G2 box; other site
497978007733	G3 box; other site
497978007734	Switch II region; other site
497978007735	G4 box; other site
497978007736	G5 box; other site
497978007737	glyceraldehyde-3-phosphate dehydrogenase; Reviewed; Region: PRK08289
497978007738	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846
497978007739	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
497978007740	Predicted permeases [General function prediction only]; Region: RarD; COG2962
497978007741	Bacterial lipocalin [Cell envelope biogenesis, outer membrane]; Region: Blc; COG3040
497978007742	Lipocalin-like domain; Region: Lipocalin_2; pfam08212
497978007743	excinuclease ABC subunit B; Provisional; Region: PRK05298
497978007744	Myosin and Kinesin motor domain. These ATPases belong to the P-loop NTPase family and provide the driving force in myosin and kinesin mediated processes; Region: Motor_domain; cl00286
497978007745	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
497978007746	ATP-binding site [chemical binding]; other site
497978007747	ATP binding site [chemical binding]; other site
497978007748	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
497978007749	nucleotide binding region [chemical binding]; other site
497978007750	ATP-binding site [chemical binding]; other site
497978007751	Ultra-violet resistance protein B; Region: UvrB; pfam12344
497978007752	UvrB/uvrC motif; Region: UVR; pfam02151
497978007753	hypothetical protein; Region: PHA00684
497978007754	PAS domain; Region: PAS_9; pfam13426
497978007755	PAS domain; Region: PAS_9; pfam13426
497978007756	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
497978007757	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
497978007758	metal binding site [ion binding]; metal-binding site
497978007759	active site
497978007760	I-site; other site
497978007761	aspartate aminotransferase; Provisional; Region: PRK05764
497978007762	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
497978007763	pyridoxal 5'-phosphate binding site [chemical binding]; other site
497978007764	homodimer interface [polypeptide binding]; other site
497978007765	catalytic residue [active]
497978007766	Uncharacterized conserved protein [Function unknown]; Region: COG3791
497978007767	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
497978007768	CoenzymeA binding site [chemical binding]; other site
497978007769	subunit interaction site [polypeptide binding]; other site
497978007770	PHB binding site; other site
497978007771	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
497978007772	malonic semialdehyde reductase; Provisional; Region: PRK10538
497978007773	NAD(P) binding site [chemical binding]; other site
497978007774	active site
497978007775	MiaE tRNA-modifying nonheme diiron monooxygenase, ferritin-like diiron-binding domain; Region: MiaE; cd07910
497978007776	active site
497978007777	dinuclear metal binding site [ion binding]; other site
497978007778	dimerization interface [polypeptide binding]; other site
497978007779	Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003
497978007780	active site
497978007781	hydrophilic channel; other site
497978007782	dimerization interface [polypeptide binding]; other site
497978007783	catalytic residues [active]
497978007784	active site lid [active]
497978007785	DNA repair protein RecO; Reviewed; Region: recO; PRK00085
497978007786	Recombination protein O N terminal; Region: RecO_N; pfam11967
497978007787	Recombination protein O C terminal; Region: RecO_C; pfam02565
497978007788	GTPase Era; Reviewed; Region: era; PRK00089
497978007789	E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163
497978007790	G1 box; other site
497978007791	GTP/Mg2+ binding site [chemical binding]; other site
497978007792	Switch I region; other site
497978007793	G2 box; other site
497978007794	Switch II region; other site
497978007795	G3 box; other site
497978007796	G4 box; other site
497978007797	G5 box; other site
497978007798	KH domain; Region: KH_2; pfam07650
497978007799	ribonuclease III; Reviewed; Region: rnc; PRK00102
497978007800	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
497978007801	dimerization interface [polypeptide binding]; other site
497978007802	active site
497978007803	metal binding site [ion binding]; metal-binding site
497978007804	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048
497978007805	dsRNA binding site [nucleotide binding]; other site
497978007806	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
497978007807	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
497978007808	Catalytic site [active]
497978007809	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
497978007810	GTP-binding protein LepA; Provisional; Region: PRK05433
497978007811	LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890
497978007812	G1 box; other site
497978007813	putative GEF interaction site [polypeptide binding]; other site
497978007814	GTP/Mg2+ binding site [chemical binding]; other site
497978007815	Switch I region; other site
497978007816	G2 box; other site
497978007817	G3 box; other site
497978007818	Switch II region; other site
497978007819	G4 box; other site
497978007820	G5 box; other site
497978007821	lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699
497978007822	lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane.   LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709
497978007823	GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421
497978007824	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
497978007825	active site
497978007826	periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037
497978007827	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
497978007828	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
497978007829	protein binding site [polypeptide binding]; other site
497978007830	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
497978007831	protein binding site [polypeptide binding]; other site
497978007832	L-aspartate oxidase; Provisional; Region: PRK09077
497978007833	L-aspartate oxidase; Provisional; Region: PRK06175
497978007834	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
497978007835	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
497978007836	CoenzymeA binding site [chemical binding]; other site
497978007837	subunit interaction site [polypeptide binding]; other site
497978007838	PHB binding site; other site
497978007839	Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672
497978007840	thymidylate kinase; Validated; Region: tmk; PRK00698
497978007841	TMP-binding site; other site
497978007842	ATP-binding site [chemical binding]; other site
497978007843	YceG-like family; Region: YceG; pfam02618
497978007844	proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010
497978007845	dimerization interface [polypeptide binding]; other site
497978007846	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
497978007847	ADCL_like: 4-Amino-4-deoxychorismate lyase:  is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate.  Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559
497978007848	pyridoxal 5'-phosphate binding site [chemical binding]; other site
497978007849	catalytic residue [active]
497978007850	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
497978007851	substrate binding pocket [chemical binding]; other site
497978007852	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
497978007853	membrane-bound complex binding site; other site
497978007854	hinge residues; other site
497978007855	Serine hydrolase; Region: Ser_hydrolase; pfam06821
497978007856	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
497978007857	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
497978007858	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
497978007859	dimer interface [polypeptide binding]; other site
497978007860	conserved gate region; other site
497978007861	putative PBP binding loops; other site
497978007862	ABC-ATPase subunit interface; other site
497978007863	sulfate transport protein; Provisional; Region: cysT; CHL00187
497978007864	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
497978007865	dimer interface [polypeptide binding]; other site
497978007866	conserved gate region; other site
497978007867	putative PBP binding loops; other site
497978007868	ABC-ATPase subunit interface; other site
497978007869	ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118
497978007870	ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296
497978007871	Walker A/P-loop; other site
497978007872	ATP binding site [chemical binding]; other site
497978007873	Q-loop/lid; other site
497978007874	ABC transporter signature motif; other site
497978007875	Walker B; other site
497978007876	D-loop; other site
497978007877	H-loop/switch region; other site
497978007878	TOBE-like domain; Region: TOBE_3; pfam12857
497978007879	transcriptional regulator CysB-like protein; Reviewed; Region: PRK12683
497978007880	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
497978007881	The C-terminal substrate domain of LysR-type transcriptional regulators CysB-like contains type 2 periplasmic binding fold; Region: PBP2_CysB_like; cd08413
497978007882	substrate binding site [chemical binding]; other site
497978007883	dimerization interface [polypeptide binding]; other site
497978007884	2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830
497978007885	2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350
497978007886	active site
497978007887	substrate binding site [chemical binding]; other site
497978007888	trimer interface [polypeptide binding]; other site
497978007889	CoA binding site [chemical binding]; other site
497978007890	putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE, gammaproteobacterial type; Region: rSAM_QueE_gams; TIGR04349
497978007891	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
497978007892	FeS/SAM binding site; other site
497978007893	ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995
497978007894	Ligand Binding Site [chemical binding]; other site
497978007895	Predicted ATPases of PP-loop superfamily [General function prediction only]; Region: COG2102
497978007896	This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily  includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which  binds to Adenosine group.  This subfamily; Region: Alpha_ANH_like_IV; cd01994
497978007897	Ligand Binding Site [chemical binding]; other site
497978007898	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
497978007899	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
497978007900	catalytic triad [active]
497978007901	Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340
497978007902	SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379
497978007903	nicotinamide-nucleotide adenylyltransferase; Provisional; Region: PRK13793
497978007904	active site
497978007905	nucleotide binding site [chemical binding]; other site
497978007906	HIGH motif; other site
497978007907	KMSKS motif; other site
497978007908	enoyl-CoA hydratase; Provisional; Region: PRK06688
497978007909	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
497978007910	substrate binding site [chemical binding]; other site
497978007911	oxyanion hole (OAH) forming residues; other site
497978007912	trimer interface [polypeptide binding]; other site
497978007913	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323
497978007914	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
497978007915	putative substrate translocation pore; other site
497978007916	phosphoribosylformylglycinamidine synthase; Provisional; Region: PRK05297
497978007917	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203
497978007918	dimerization interface [polypeptide binding]; other site
497978007919	ATP binding site [chemical binding]; other site
497978007920	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204
497978007921	dimerization interface [polypeptide binding]; other site
497978007922	ATP binding site [chemical binding]; other site
497978007923	Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740
497978007924	putative active site [active]
497978007925	catalytic triad [active]
497978007926	deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01096
497978007927	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
497978007928	Zn2+ binding site [ion binding]; other site
497978007929	Mg2+ binding site [ion binding]; other site
497978007930	Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116
497978007931	RuvA N terminal domain; Region: RuvA_N; pfam01330
497978007932	RuvA, C-terminal domain; Region: RuvA_C; pfam07499
497978007933	Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080
497978007934	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078
497978007935	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
497978007936	Walker A motif; other site
497978007937	ATP binding site [chemical binding]; other site
497978007938	Walker B motif; other site
497978007939	arginine finger; other site
497978007940	Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491
497978007941	M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like2; cd05667
497978007942	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
497978007943	metal binding site [ion binding]; metal-binding site
497978007944	putative dimer interface [polypeptide binding]; other site
497978007945	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
497978007946	active site
497978007947	TolQ protein; Region: tolQ; TIGR02796
497978007948	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
497978007949	TolR protein; Region: tolR; TIGR02801
497978007950	TolA protein; Region: tolA_full; TIGR02794
497978007951	TonB C terminal; Region: TonB_2; pfam13103
497978007952	translocation protein TolB; Provisional; Region: tolB; PRK04922
497978007953	TolB amino-terminal domain; Region: TolB_N; pfam04052
497978007954	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
497978007955	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
497978007956	putative outer membrane lipoprotein; Provisional; Region: PRK09967
497978007957	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
497978007958	ligand binding site [chemical binding]; other site
497978007959	fructose-1,6-bisphosphatase family protein; Region: PLN02628
497978007960	Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate  into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354
497978007961	AMP binding site [chemical binding]; other site
497978007962	metal binding site [ion binding]; metal-binding site
497978007963	active site
497978007964	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
497978007965	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
497978007966	RNA polymerase factor sigma-70; Validated; Region: PRK09047
497978007967	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
497978007968	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
497978007969	DNA binding residues [nucleotide binding]
497978007970	Protein of unknown function (DUF3106); Region: DUF3106; pfam11304
497978007971	Acinetobacter rhombotarget A; Region: GlyGly_RbtA; TIGR04212
497978007972	CSLREA domain; Region: CSLREA_Nterm; TIGR04214
497978007973	Acinetobacter rhombotarget A; Region: GlyGly_RbtA; TIGR04212
497978007974	CSLREA domain; Region: CSLREA_Nterm; TIGR04214
497978007975	ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593
497978007976	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
497978007977	Walker A motif; other site
497978007978	ATP binding site [chemical binding]; other site
497978007979	Walker B motif; other site
497978007980	arginine finger; other site
497978007981	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
497978007982	Domain of unknown function DUF20; Region: UPF0118; pfam01594
497978007983	phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385
497978007984	PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196
497978007985	dimerization interface [polypeptide binding]; other site
497978007986	putative ATP binding site [chemical binding]; other site
497978007987	phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647
497978007988	Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645
497978007989	active site
497978007990	substrate binding site [chemical binding]; other site
497978007991	cosubstrate binding site; other site
497978007992	catalytic site [active]
497978007993	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
497978007994	Periplasmic serine proteases (ClpP class) [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: SppA; COG0616
497978007995	Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023
497978007996	tandem repeat interface [polypeptide binding]; other site
497978007997	oligomer interface [polypeptide binding]; other site
497978007998	active site residues [active]
497978007999	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
497978008000	putative acyl-acceptor binding pocket; other site
497978008001	Domain of unknown function (DUF4131); Region: DUF4131; pfam13567
497978008002	Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658
497978008003	Competence protein; Region: Competence; pfam03772
497978008004	Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333
497978008005	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
497978008006	lipoprotein releasing system, ATP-binding protein; Region: LolD_lipo_ex; TIGR02211
497978008007	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
497978008008	Walker A/P-loop; other site
497978008009	ATP binding site [chemical binding]; other site
497978008010	Q-loop/lid; other site
497978008011	ABC transporter signature motif; other site
497978008012	Walker B; other site
497978008013	D-loop; other site
497978008014	H-loop/switch region; other site
497978008015	lipoprotein releasing system, transmembrane protein, LolC/E family; Region: lolCE; TIGR02212
497978008016	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
497978008017	FtsX-like permease family; Region: FtsX; pfam02687
497978008018	putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272
497978008019	EamA-like transporter family; Region: EamA; pfam00892
497978008020	Uncharacterized BCR, YaiI/YqxD family COG1671; Region: DUF188; pfam02639
497978008021	Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT).  PSAT is active as...; Region: PSAT_like; cd00611
497978008022	homodimer interface [polypeptide binding]; other site
497978008023	substrate-cofactor binding pocket; other site
497978008024	pyridoxal 5'-phosphate binding site [chemical binding]; other site
497978008025	catalytic residue [active]
497978008026	Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538
497978008027	Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566
497978008028	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
497978008029	HlyD family secretion protein; Region: HlyD_3; pfam13437
497978008030	YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061
497978008031	ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698
497978008032	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
497978008033	ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698
497978008034	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
497978008035	uncharacterized YdjC-like family proteins from bacteria; Region: YdjC_like_3; cd10807
497978008036	putative active site [active]
497978008037	YdjC motif; other site
497978008038	Mg binding site [ion binding]; other site
497978008039	putative homodimer interface [polypeptide binding]; other site
497978008040	undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714
497978008041	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
497978008042	Ligand binding site; other site
497978008043	Putative Catalytic site; other site
497978008044	DXD motif; other site
497978008045	GtrA-like protein; Region: GtrA; pfam04138
497978008046	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807
497978008047	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364
497978008048	DNA gyrase subunit A; Validated; Region: PRK05560
497978008049	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
497978008050	CAP-like domain; other site
497978008051	active site
497978008052	primary dimer interface [polypeptide binding]; other site
497978008053	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
497978008054	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
497978008055	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
497978008056	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
497978008057	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
497978008058	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
497978008059	electron transfer flavoprotein subunit alpha; Provisional; Region: PLN00022
497978008060	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715
497978008061	Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766
497978008062	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714
497978008063	Ligand binding site [chemical binding]; other site
497978008064	Electron transfer flavoprotein domain; Region: ETF; pfam01012
497978008065	site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236
497978008066	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
497978008067	active site
497978008068	DNA binding site [nucleotide binding]
497978008069	Int/Topo IB signature motif; other site
497978008070	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
497978008071	diaminopimelate epimerase; Provisional; Region: dapF; PRK00450
497978008072	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
497978008073	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
497978008074	diaminopimelate decarboxylase; Region: lysA; TIGR01048
497978008075	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828
497978008076	active site
497978008077	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
497978008078	substrate binding site [chemical binding]; other site
497978008079	catalytic residues [active]
497978008080	dimer interface [polypeptide binding]; other site
497978008081	D-alanine/D-serine/glycine permease; Provisional; Region: PRK11049
497978008082	DNA repair protein RadA; Provisional; Region: PRK11823
497978008083	Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121
497978008084	Walker A motif/ATP binding site; other site
497978008085	ATP binding site [chemical binding]; other site
497978008086	Walker B motif; other site
497978008087	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
497978008088	Tim44 is an essential component of the machinery that mediates the translocation of nuclear-encoded proteins across the mitochondrial inner membrane; Region: Tim44; smart00978
497978008089	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
497978008090	EF-P lysine aminoacylase GenX; Region: genX; TIGR00462
497978008091	motif 1; other site
497978008092	dimer interface [polypeptide binding]; other site
497978008093	active site
497978008094	motif 2; other site
497978008095	motif 3; other site
497978008096	erythronate-4-phosphate dehydrogenase; Validated; Region: PRK00257
497978008097	D-Erythronate-4-Phosphate Dehydrogenase NAD-binding and catalytic domains; Region: ErythrP_dh; cd12158
497978008098	ligand binding site [chemical binding]; other site
497978008099	NAD binding site [chemical binding]; other site
497978008100	catalytic site [active]
497978008101	homodimer interface [polypeptide binding]; other site
497978008102	Protein of unknown function (DUF1232); Region: DUF1232; cl01318
497978008103	formate dehydrogenase accessory protein; Reviewed; Region: PRK00724
497978008104	oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701
497978008105	The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767
497978008106	putative molybdopterin cofactor binding site [chemical binding]; other site
497978008107	The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787
497978008108	putative molybdopterin cofactor binding site; other site
497978008109	Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929
497978008110	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
497978008111	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
497978008112	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
497978008113	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
497978008114	NAD(P) binding site [chemical binding]; other site
497978008115	active site
497978008116	Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137
497978008117	dimer interface [polypeptide binding]; other site
497978008118	FMN binding site [chemical binding]; other site
497978008119	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
497978008120	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
497978008121	Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687
497978008122	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
497978008123	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
497978008124	The adenylation (A) domain of siderophore-synthesizing nonribosomal peptide synthetases (NRPS); Region: A_NRPS_SidN3_like; cd05918
497978008125	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
497978008126	acyl-activating enzyme (AAE) consensus motif; other site
497978008127	AMP binding site [chemical binding]; other site
497978008128	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
497978008129	non-ribosomal peptide synthetase terminal domain of unknown function; Region: NRPS_term_dom; TIGR02353
497978008130	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
497978008131	putative trimer interface [polypeptide binding]; other site
497978008132	putative CoA binding site [chemical binding]; other site
497978008133	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
497978008134	putative CoA binding site [chemical binding]; other site
497978008135	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
497978008136	Calcium/calmodulin dependent protein kinase II Association; Region: CaMKII_AD; cl17504
497978008137	transcription elongation factor GreB; Reviewed; Region: greB; PRK01885
497978008138	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
497978008139	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
497978008140	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
497978008141	N-acetyl-D-glucosamine binding site [chemical binding]; other site
497978008142	catalytic residue [active]
497978008143	SCP-2 sterol transfer family; Region: SCP2; pfam02036
497978008144	tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696
497978008145	This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily  includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which  binds to Adenosine group.  This subfamily; Region: Alpha_ANH_like_II; cd01993
497978008146	Ligand Binding Site [chemical binding]; other site
497978008147	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
497978008148	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
497978008149	N-acetyl-D-glucosamine binding site [chemical binding]; other site
497978008150	catalytic residue [active]
497978008151	heat shock protein HtpX; Provisional; Region: PRK05457
497978008152	Domain of unknown function (DUF4112); Region: DUF4112; pfam13430
497978008153	The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915
497978008154	Protein export membrane protein; Region: SecD_SecF; cl14618
497978008155	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
497978008156	Glycerophosphodiester phosphodiesterase domain of Streptomycin coelicolor (GlpQ1) and similar proteins; Region: GDPD_ScGlpQ1_like; cd08602
497978008157	putative active site [active]
497978008158	catalytic site [active]
497978008159	putative metal binding site [ion binding]; other site
497978008160	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
497978008161	Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818
497978008162	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
497978008163	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
497978008164	ring oligomerisation interface [polypeptide binding]; other site
497978008165	ATP/Mg binding site [chemical binding]; other site
497978008166	stacking interactions; other site
497978008167	hinge regions; other site
497978008168	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
497978008169	oligomerisation interface [polypeptide binding]; other site
497978008170	mobile loop; other site
497978008171	roof hairpin; other site
497978008172	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
497978008173	Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753
497978008174	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
497978008175	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
497978008176	type I secretion C-terminal target domain (VC_A0849 subclass); Region: T1SS_VCA0849; TIGR03661
497978008177	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
497978008178	Bacillus subtilis YydB and related proteins, metallophosphatase domain; Region: MPP_YydB; cd07400
497978008179	putative active site [active]
497978008180	putative metal binding site [ion binding]; other site
497978008181	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
497978008182	active site
497978008183	metal binding site [ion binding]; metal-binding site
497978008184	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
497978008185	Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597
497978008186	Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819
497978008187	active site
497978008188	substrate-binding site [chemical binding]; other site
497978008189	metal-binding site [ion binding]
497978008190	GTP binding site [chemical binding]; other site
497978008191	glycerol-3-phosphate dehydrogenase; Reviewed; Region: glpD; PRK12266
497978008192	glycerol kinase; Provisional; Region: glpK; PRK00047
497978008193	Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786
497978008194	N- and C-terminal domain interface [polypeptide binding]; other site
497978008195	active site
497978008196	MgATP binding site [chemical binding]; other site
497978008197	catalytic site [active]
497978008198	metal binding site [ion binding]; metal-binding site
497978008199	glycerol binding site [chemical binding]; other site
497978008200	homotetramer interface [polypeptide binding]; other site
497978008201	homodimer interface [polypeptide binding]; other site
497978008202	FBP binding site [chemical binding]; other site
497978008203	protein IIAGlc interface [polypeptide binding]; other site
497978008204	alpha-ketoglutarate transporter; Provisional; Region: PRK10406
497978008205	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
497978008206	putative substrate translocation pore; other site
497978008207	Predicted methyltransferase [General function prediction only]; Region: COG3897
497978008208	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
497978008209	S-adenosylmethionine binding site [chemical binding]; other site
497978008210	bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14192
497978008211	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
497978008212	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
497978008213	homodimer interface [polypeptide binding]; other site
497978008214	NADP binding site [chemical binding]; other site
497978008215	substrate binding site [chemical binding]; other site
497978008216	PhoD-like phosphatase; Region: PhoD; pfam09423
497978008217	Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389
497978008218	putative active site [active]
497978008219	putative metal binding site [ion binding]; other site
497978008220	Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389
497978008221	DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
497978008222	dihydropteroate synthase; Region: DHPS; TIGR01496
497978008223	substrate binding pocket [chemical binding]; other site
497978008224	dimer interface [polypeptide binding]; other site
497978008225	inhibitor binding site; inhibition site
497978008226	FtsH Extracellular; Region: FtsH_ext; pfam06480
497978008227	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
497978008228	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
497978008229	Walker A motif; other site
497978008230	ATP binding site [chemical binding]; other site
497978008231	Walker B motif; other site
497978008232	arginine finger; other site
497978008233	Peptidase family M41; Region: Peptidase_M41; pfam01434
497978008234	FtsJ-like methyltransferase; Region: FtsJ; cl17430
497978008235	23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293
497978008236	Escherichia coli YhbY is associated with pre-50S ribosomal subunits, which implies a function in ribosome assembly; Region: CRS1_YhbY; smart01103
497978008237	Domon-like domain of UDP-N-acetylenolpyruvoylglucosamine reductase; Region: DOMON_murB_like; cd09627
497978008238	putative heme binding site [chemical binding]; other site
497978008239	carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564
497978008240	Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097
497978008241	Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744
497978008242	catalytic site [active]
497978008243	subunit interface [polypeptide binding]; other site
497978008244	carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294
497978008245	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
497978008246	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
497978008247	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
497978008248	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
497978008249	ATP-grasp domain; Region: ATP-grasp_4; cl17255
497978008250	Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424
497978008251	IMP binding site; other site
497978008252	dimer interface [polypeptide binding]; other site
497978008253	interdomain contacts; other site
497978008254	partial ornithine binding site; other site
497978008255	transcription elongation factor GreA; Reviewed; Region: greA; PRK00226
497978008256	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
497978008257	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
497978008258	Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110
497978008259	Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349
497978008260	trimer interface [polypeptide binding]; other site
497978008261	active site
497978008262	substrate binding site [chemical binding]; other site
497978008263	CoA binding site [chemical binding]; other site
497978008264	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
497978008265	Ligand Binding Site [chemical binding]; other site
497978008266	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
497978008267	DNA binding site [nucleotide binding]
497978008268	active site
497978008269	Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064
497978008270	active site
497978008271	CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381
497978008272	putative active site [active]
497978008273	putative metal binding site [ion binding]; other site
497978008274	Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854
497978008275	type 2 lantibiotic biosynthesis protein LanM; Region: lanti_2_LanM; TIGR03897
497978008276	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
497978008277	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
497978008278	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
497978008279	tail sheath protein; Provisional; Region: 18; PHA02539
497978008280	Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753
497978008281	NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025
497978008282	Predicted metalloprotease [General function prediction only]; Region: COG2321
497978008283	Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228
497978008284	Protein of unknown function (DUF808); Region: DUF808; pfam05661
497978008285	tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282
497978008286	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
497978008287	active site
497978008288	HIGH motif; other site
497978008289	dimer interface [polypeptide binding]; other site
497978008290	KMSKS motif; other site
497978008291	succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678
497978008292	CoA binding domain; Region: CoA_binding; smart00881
497978008293	CoA-ligase; Region: Ligase_CoA; pfam00549
497978008294	succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696
497978008295	ATP-grasp domain; Region: ATP-grasp_2; pfam08442
497978008296	CoA-ligase; Region: Ligase_CoA; pfam00549
497978008297	dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06467
497978008298	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
497978008299	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
497978008300	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
497978008301	dihydrolipoamide succinyltransferase; Validated; Region: PRK05704
497978008302	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
497978008303	E3 interaction surface; other site
497978008304	lipoyl attachment site [posttranslational modification]; other site
497978008305	e3 binding domain; Region: E3_binding; pfam02817
497978008306	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
497978008307	2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404
497978008308	Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016
497978008309	TPP-binding site [chemical binding]; other site
497978008310	Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779
497978008311	succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950
497978008312	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085
497978008313	succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07057
497978008314	L-aspartate oxidase; Provisional; Region: PRK06175
497978008315	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
497978008316	Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. E. coli SQR, a member of this subfamily, reduces the...; Region: SQR_TypeC_SdhD; cd03494
497978008317	SdhC subunit interface [polypeptide binding]; other site
497978008318	proximal heme binding site [chemical binding]; other site
497978008319	cardiolipin binding site; other site
497978008320	Iron-sulfur protein interface; other site
497978008321	proximal quinone binding site [chemical binding]; other site
497978008322	Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499
497978008323	Iron-sulfur protein interface; other site
497978008324	proximal quinone binding site [chemical binding]; other site
497978008325	SdhD (CybS) interface [polypeptide binding]; other site
497978008326	proximal heme binding site [chemical binding]; other site
497978008327	Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114
497978008328	Citrate synthase [Energy production and conversion]; Region: GltA; COG0372
497978008329	dimer interface [polypeptide binding]; other site
497978008330	active site
497978008331	citrylCoA binding site [chemical binding]; other site
497978008332	NADH binding [chemical binding]; other site
497978008333	cationic pore residues; other site
497978008334	oxalacetate/citrate binding site [chemical binding]; other site
497978008335	coenzyme A binding site [chemical binding]; other site
497978008336	catalytic triad [active]
497978008337	Protein of unknown function (DUF1289); Region: DUF1289; pfam06945
497978008338	Predicted sulfurtransferase [General function prediction only]; Region: COG1054
497978008339	Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518
497978008340	active site residue [active]
497978008341	Uncharacterized protein family (UPF0149); Region: UPF0149; pfam03695
497978008342	Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979
497978008343	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
497978008344	Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546
497978008345	RNA polymerase sigma factor RpoD, C-terminal domain; Region: RpoD_Cterm; TIGR02393
497978008346	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
497978008347	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
497978008348	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
497978008349	DNA binding residues [nucleotide binding]
497978008350	Protein of unknown function (DUF493); Region: DUF493; pfam04359
497978008351	lipoate-protein ligase B; Provisional; Region: PRK14342
497978008352	Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454
497978008353	Iron-containing alcohol dehydrogenases-like; Region: Fe-ADH5; cd08189
497978008354	putative active site [active]
497978008355	metal binding site [ion binding]; metal-binding site
497978008356	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
497978008357	Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655
497978008358	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
497978008359	Predicted transcriptional regulators [Transcription]; Region: COG1733
497978008360	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
497978008361	Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219
497978008362	siroheme synthase; Provisional; Region: cysG; PRK10637
497978008363	Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241
497978008364	Sirohaem synthase dimerisation region; Region: CysG_dimeriser; pfam10414
497978008365	Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642
497978008366	active site
497978008367	SAM binding site [chemical binding]; other site
497978008368	homodimer interface [polypeptide binding]; other site
497978008369	seryl-tRNA synthetase; Provisional; Region: PRK05431
497978008370	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
497978008371	Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770
497978008372	dimer interface [polypeptide binding]; other site
497978008373	active site
497978008374	motif 1; other site
497978008375	motif 2; other site
497978008376	motif 3; other site
497978008377	Protein of unknown function (DUF3298); Region: DUF3298; pfam11738
497978008378	lipoprotein chaperone; Reviewed; Region: lolA; PRK00031
497978008379	Outer membrane lipoprotein carrier protein LolA; Region: LolA; pfam03548
497978008380	50S ribosomal protein L27; Validated; Region: rpmA; PRK05435
497978008381	50S ribosomal protein L21; Validated; Region: rplU; PRK05573
497978008382	50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278
497978008383	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
497978008384	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
497978008385	substrate binding pocket [chemical binding]; other site
497978008386	chain length determination region; other site
497978008387	substrate-Mg2+ binding site; other site
497978008388	catalytic residues [active]
497978008389	aspartate-rich region 1; other site
497978008390	active site lid residues [active]
497978008391	aspartate-rich region 2; other site
497978008392	Site-specific recombinase; Region: SpecificRecomb; pfam10136
497978008393	PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392
497978008394	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
497978008395	active site
497978008396	multidrug efflux system transporter AcrA; Provisional; Region: PRK15030
497978008397	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
497978008398	HlyD family secretion protein; Region: HlyD_3; pfam13437
497978008399	The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915
497978008400	Protein export membrane protein; Region: SecD_SecF; cl14618
497978008401	Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538
497978008402	Putative heavy-metal-binding; Region: YbjQ_1; cl00426
497978008403	Uncharacterized conserved protein [Function unknown]; Region: COG0393
497978008404	SnoaL-like domain; Region: SnoaL_4; pfam13577
497978008405	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
497978008406	short chain dehydrogenase; Provisional; Region: PRK06181
497978008407	NAD(P) binding site [chemical binding]; other site
497978008408	active site
497978008409	valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729
497978008410	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
497978008411	HIGH motif; other site
497978008412	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
497978008413	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
497978008414	active site
497978008415	KMSKS motif; other site
497978008416	Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962
497978008417	tRNA binding surface [nucleotide binding]; other site
497978008418	anticodon binding site; other site
497978008419	Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458
497978008420	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
497978008421	S-adenosylmethionine binding site [chemical binding]; other site
497978008422	Predicted permeases [General function prediction only]; Region: COG0679
497978008423	putative DNA-binding transcriptional regulator; Provisional; Region: PRK10837
497978008424	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
497978008425	putative DNA binding site [nucleotide binding]; other site
497978008426	putative Zn2+ binding site [ion binding]; other site
497978008427	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
497978008428	dimerization interface [polypeptide binding]; other site
497978008429	Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004
497978008430	PAP2_like_6 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which mainly contains bacterial proteins, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_6; cd03396
497978008431	active site
497978008432	sensor protein QseC; Provisional; Region: PRK10337
497978008433	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
497978008434	dimer interface [polypeptide binding]; other site
497978008435	phosphorylation site [posttranslational modification]
497978008436	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
497978008437	ATP binding site [chemical binding]; other site
497978008438	Mg2+ binding site [ion binding]; other site
497978008439	G-X-G motif; other site
497978008440	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
497978008441	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
497978008442	active site
497978008443	phosphorylation site [posttranslational modification]
497978008444	intermolecular recognition site; other site
497978008445	dimerization interface [polypeptide binding]; other site
497978008446	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
497978008447	DNA binding site [nucleotide binding]
497978008448	putative metal dependent hydrolase; Provisional; Region: PRK11598
497978008449	Domain of unknown function (DUF1705); Region: DUF1705; pfam08019
497978008450	Sulfatase; Region: Sulfatase; pfam00884
497978008451	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
497978008452	muropeptide transporter; Validated; Region: ampG; cl17669
497978008453	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
497978008454	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown ABO13168; Region: LPLAT_ABO13168-like; cd07988
497978008455	putative acyl-acceptor binding pocket; other site
497978008456	hypothetical protein; Provisional; Region: PRK10279
497978008457	Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205
497978008458	nucleophile elbow; other site
497978008459	Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585
497978008460	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
497978008461	Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403
497978008462	Protein of unknown function (DUF419); Region: DUF419; cl15265
497978008463	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
497978008464	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
497978008465	substrate binding pocket [chemical binding]; other site
497978008466	chain length determination region; other site
497978008467	substrate-Mg2+ binding site; other site
497978008468	catalytic residues [active]
497978008469	aspartate-rich region 1; other site
497978008470	active site lid residues [active]
497978008471	aspartate-rich region 2; other site
497978008472	probable AcnD-accessory protein PrpF; Region: prpF; TIGR02334
497978008473	Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113
497978008474	chaperone protein HchA; Provisional; Region: PRK04155
497978008475	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
497978008476	conserved cys residue [active]
497978008477	putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824
497978008478	PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276
497978008479	NAD(P) binding site [chemical binding]; other site
497978008480	AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719
497978008481	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
497978008482	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
497978008483	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
497978008484	undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281
497978008485	Mrr N-terminal domain; Region: Mrr_N; pfam14338
497978008486	PaaX-like protein C-terminal domain; Region: PaaX_C; pfam08223
497978008487	This CD includes the dihydrorhizobitoxine fatty acid desaturase (RtxC) characterized in Bradyrhizobium japonicum USDA110, and other related proteins. Dihydrorhizobitoxine desaturase is reported to be involved in the final step of rhizobitoxine...; Region: Rhizobitoxine-FADS-like; cd03510
497978008488	putative di-iron ligands [ion binding]; other site
497978008489	This CD includes the dihydrorhizobitoxine fatty acid desaturase (RtxC) characterized in Bradyrhizobium japonicum USDA110, and other related proteins. Dihydrorhizobitoxine desaturase is reported to be involved in the final step of rhizobitoxine...; Region: Rhizobitoxine-FADS-like; cd03510
497978008490	Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625
497978008491	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
497978008492	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
497978008493	Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525
497978008494	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
497978008495	Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; cl17479
497978008496	Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; cl17479
497978008497	phosphoserine phosphatase; Provisional; Region: thrH; PRK13582
497978008498	Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560
497978008499	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
497978008500	Active Sites [active]
497978008501	acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946
497978008502	Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007
497978008503	ribonuclease G; Provisional; Region: PRK11712
497978008504	S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453
497978008505	homodimer interface [polypeptide binding]; other site
497978008506	oligonucleotide binding site [chemical binding]; other site
497978008507	Maf-like protein; Region: Maf; pfam02545
497978008508	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
497978008509	active site
497978008510	dimer interface [polypeptide binding]; other site
497978008511	rod shape-determining protein MreD; Region: shape_MreD; TIGR03426
497978008512	rod shape-determining protein MreC; Provisional; Region: PRK13922
497978008513	rod shape-determining protein MreC; Region: MreC; pfam04085
497978008514	rod shape-determining protein MreB; Provisional; Region: PRK13927
497978008515	MreB and similar proteins; Region: MreB_like; cd10225
497978008516	nucleotide binding site [chemical binding]; other site
497978008517	Mg binding site [ion binding]; other site
497978008518	putative protofilament interaction site [polypeptide binding]; other site
497978008519	RodZ interaction site [polypeptide binding]; other site
497978008520	aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034
497978008521	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
497978008522	aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012
497978008523	aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477
497978008524	GatB/GatE catalytic domain; Region: GatB_N; pfam02934
497978008525	GatB domain; Region: GatB_Yqey; smart00845
497978008526	intracellular protease, PfpI family; Region: PfpI; TIGR01382
497978008527	Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_1; cd03169
497978008528	conserved cys residue [active]
497978008529	Protein of unknown function (DUF1176); Region: DUF1176; pfam06674
497978008530	microcin B17 transporter; Reviewed; Region: PRK11098
497978008531	threonine dehydratase; Provisional; Region: PRK07334
497978008532	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
497978008533	tetramer interface [polypeptide binding]; other site
497978008534	pyridoxal 5'-phosphate binding site [chemical binding]; other site
497978008535	catalytic residue [active]
497978008536	C-terminal ACT domain of biodegradative (catabolic) threonine dehydratase II (ThrD-II) and other related ACT domains; Region: ACT_ThrD-II-like; cd04886
497978008537	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752
497978008538	Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205
497978008539	active site
497978008540	nucleophile elbow; other site
497978008541	Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115
497978008542	Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548
497978008543	Nitroreductase family. Members of this family utilize FMN as a cofactor and catalyze reduction of a variety of nitroaromatic compounds, including nitrofurans, nitrobenzens, nitrophenol, nitrobenzoate and quinones by using either NADH or NADPH as a source...; Region: Nitroreductase; cd02136
497978008544	putative FMN binding site [chemical binding]; other site
497978008545	bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102
497978008546	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
497978008547	putative substrate translocation pore; other site
497978008548	TIGR01666 family membrane protein; Region: YCCS
497978008549	FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805
497978008550	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
497978008551	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
497978008552	YcxB-like protein; Region: YcxB; pfam14317
497978008553	Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182
497978008554	PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172
497978008555	PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703
497978008556	Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; Region: CysJ; COG0369
497978008557	Flavodoxin; Region: Flavodoxin_1; pfam00258
497978008558	Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR_like1; cd06200
497978008559	FAD binding pocket [chemical binding]; other site
497978008560	FAD binding motif [chemical binding]; other site
497978008561	catalytic residues [active]
497978008562	NAD binding pocket [chemical binding]; other site
497978008563	phosphate binding motif [ion binding]; other site
497978008564	beta-alpha-beta structure motif; other site
497978008565	Uncharacterized conserved protein [Function unknown]; Region: COG1434
497978008566	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
497978008567	putative active site [active]
497978008568	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
497978008569	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
497978008570	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2832
497978008571	Domain of unknown function (DUF1853); Region: DUF1853; cl01545
497978008572	Predicted small secreted protein [Function unknown]; Region: COG5510
497978008573	succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009
497978008574	M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891
497978008575	metal binding site [ion binding]; metal-binding site
497978008576	dimer interface [polypeptide binding]; other site
497978008577	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
497978008578	putative binding surface; other site
497978008579	active site
497978008580	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
497978008581	putative binding surface; other site
497978008582	active site
497978008583	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
497978008584	putative binding surface; other site
497978008585	active site
497978008586	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
497978008587	putative binding surface; other site
497978008588	active site
497978008589	Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895
497978008590	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
497978008591	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
497978008592	ATP binding site [chemical binding]; other site
497978008593	Mg2+ binding site [ion binding]; other site
497978008594	G-X-G motif; other site
497978008595	CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731
497978008596	Response regulator receiver domain; Region: Response_reg; pfam00072
497978008597	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
497978008598	active site
497978008599	phosphorylation site [posttranslational modification]
497978008600	intermolecular recognition site; other site
497978008601	dimerization interface [polypeptide binding]; other site
497978008602	Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675
497978008603	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
497978008604	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
497978008605	dimer interface [polypeptide binding]; other site
497978008606	putative CheW interface [polypeptide binding]; other site
497978008607	Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835
497978008608	Response regulator receiver domain; Region: Response_reg; pfam00072
497978008609	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
497978008610	active site
497978008611	phosphorylation site [posttranslational modification]
497978008612	intermolecular recognition site; other site
497978008613	dimerization interface [polypeptide binding]; other site
497978008614	Response regulator receiver domain; Region: Response_reg; pfam00072
497978008615	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
497978008616	active site
497978008617	phosphorylation site [posttranslational modification]
497978008618	intermolecular recognition site; other site
497978008619	dimerization interface [polypeptide binding]; other site
497978008620	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
497978008621	HlyD family secretion protein; Region: HlyD_3; pfam13437
497978008622	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
497978008623	prolyl-tRNA synthetase; Provisional; Region: PRK09194
497978008624	Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779
497978008625	dimer interface [polypeptide binding]; other site
497978008626	motif 1; other site
497978008627	active site
497978008628	motif 2; other site
497978008629	INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334
497978008630	putative deacylase active site [active]
497978008631	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
497978008632	active site
497978008633	motif 3; other site
497978008634	ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861
497978008635	anticodon binding site; other site
497978008636	Uncharacterized conserved protein [Function unknown]; Region: COG3422
497978008637	Domain of unknown function (DUF1508); Region: DUF1508; pfam07411
497978008638	Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824
497978008639	PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274
497978008640	PhnA protein; Region: PhnA; pfam03831
497978008641	Uncharacterized conserved protein [Function unknown]; Region: COG3189
497978008642	Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_2; cd08895
497978008643	putative hydrophobic ligand binding site [chemical binding]; other site
497978008644	Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354
497978008645	folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317
497978008646	protein disulfide isomerase II DsbC; Provisional; Region: PRK10877
497978008647	DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020
497978008648	dimerization domain [polypeptide binding]; other site
497978008649	dimer interface [polypeptide binding]; other site
497978008650	catalytic residues [active]
497978008651	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
497978008652	Sel1-like repeats; Region: SEL1; smart00671
497978008653	Predicted permeases [General function prediction only]; Region: COG0679
497978008654	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
497978008655	Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis.  Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932
497978008656	active site
497978008657	FMN binding site [chemical binding]; other site
497978008658	substrate binding site [chemical binding]; other site
497978008659	homotetramer interface [polypeptide binding]; other site
497978008660	catalytic residue [active]
497978008661	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
497978008662	Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540
497978008663	active site
497978008664	DNA binding site [nucleotide binding]
497978008665	formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103
497978008666	N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966
497978008667	DNA binding site [nucleotide binding]
497978008668	catalytic residue [active]
497978008669	H2TH interface [polypeptide binding]; other site
497978008670	putative catalytic residues [active]
497978008671	turnover-facilitating residue; other site
497978008672	intercalation triad [nucleotide binding]; other site
497978008673	8OG recognition residue [nucleotide binding]; other site
497978008674	putative reading head residues; other site
497978008675	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
497978008676	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
497978008677	PPIC-type PPIASE domain; Region: Rotamase_2; cl08278
497978008678	GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661
497978008679	putative active site pocket [active]
497978008680	dimerization interface [polypeptide binding]; other site
497978008681	putative catalytic residue [active]
497978008682	large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13952
497978008683	large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567
497978008684	Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217
497978008685	Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891
497978008686	G1 box; other site
497978008687	putative GEF interaction site [polypeptide binding]; other site
497978008688	GTP/Mg2+ binding site [chemical binding]; other site
497978008689	Switch I region; other site
497978008690	G2 box; other site
497978008691	G3 box; other site
497978008692	Switch II region; other site
497978008693	G4 box; other site
497978008694	G5 box; other site
497978008695	BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu.  BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691
497978008696	BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants.  BipA is a highly...; Region: BipA_TypA_C; cd03710
497978008697	Xanthine/uracil permeases [Nucleotide transport and metabolism]; Region: UraA; COG2233
497978008698	16S ribosomal RNA m2G1207 methyltransferase; Provisional; Region: rsmC; PRK09489
497978008699	Methyltransferase small domain N-terminal; Region: MTS_N; pfam08468
497978008700	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
497978008701	S-adenosylmethionine binding site [chemical binding]; other site
497978008702	lysine transporter; Provisional; Region: PRK10836
497978008703	Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139
497978008704	hypothetical protein; Reviewed; Region: PRK09588
497978008705	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505
497978008706	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
497978008707	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
497978008708	ligand binding site [chemical binding]; other site
497978008709	Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830
497978008710	Type II transport protein GspH; Region: GspH; pfam12019
497978008711	acetyl-CoA acetyltransferase; Provisional; Region: PRK06954
497978008712	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
497978008713	dimer interface [polypeptide binding]; other site
497978008714	active site
497978008715	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
497978008716	Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588
497978008717	dimer interface [polypeptide binding]; other site
497978008718	Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076
497978008719	Bacterial protein of unknown function (DUF934); Region: DUF934; pfam06073
497978008720	Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155
497978008721	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
497978008722	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
497978008723	membrane-bound PQQ-dependent dehydrogenase, glucose/quinate/shikimate family; Region: PQQ_membr_DH; TIGR03074
497978008724	Membrane-bound PQQ-dependent glucose dehydrogenase; Region: PQQ_mGDH; cd10280
497978008725	Trp docking motif [polypeptide binding]; other site
497978008726	putative active site [active]
497978008727	Carbohydrate-selective porin, OprB family; Region: OprB; cl17816
497978008728	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
497978008729	CoA-transferase family III; Region: CoA_transf_3; pfam02515
497978008730	Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625
497978008731	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
497978008732	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
497978008733	acetyl-CoA acetyltransferase; Validated; Region: PRK08242
497978008734	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
497978008735	dimer interface [polypeptide binding]; other site
497978008736	active site
497978008737	multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154
497978008738	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
497978008739	substrate binding site [chemical binding]; other site
497978008740	oxyanion hole (OAH) forming residues; other site
497978008741	trimer interface [polypeptide binding]; other site
497978008742	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
497978008743	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
497978008744	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667
497978008745	Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208
497978008746	active site
497978008747	nucleophile elbow; other site
497978008748	Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; pfam13444
497978008749	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
497978008750	Haemolysin-III related; Region: HlyIII; cl03831
497978008751	channel protein, hemolysin III family; Region: hlyIII; TIGR01065
497978008752	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
497978008753	metabolite-proton symporter; Region: 2A0106; TIGR00883
497978008754	putative substrate translocation pore; other site
497978008755	preprotein translocase subunit SecA; Reviewed; Region: PRK12904
497978008756	SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958
497978008757	SEC-C motif; Region: SEC-C; pfam02810
497978008758	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
497978008759	Peroxiredoxin (PRX) family, 1-cys PRX subfamily; composed of PRXs containing only one conserved cysteine, which serves as the peroxidatic cysteine. They are homodimeric thiol-specific antioxidant (TSA) proteins that confer a protective role in cells by...; Region: PRX_1cys; cd03016
497978008760	dimer interface [polypeptide binding]; other site
497978008761	decamer (pentamer of dimers) interface [polypeptide binding]; other site
497978008762	catalytic triad [active]
497978008763	Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753
497978008764	Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053
497978008765	active site
497978008766	catalytic residues [active]
497978008767	Sporulation related domain; Region: SPOR; cl10051
497978008768	Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285
497978008769	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
497978008770	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
497978008771	acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654
497978008772	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
497978008773	tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200
497978008774	Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724
497978008775	substrate binding site [chemical binding]; other site
497978008776	active site
497978008777	catalytic residues [active]
497978008778	heterodimer interface [polypeptide binding]; other site
497978008779	Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625
497978008780	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
497978008781	Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687
497978008782	Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118
497978008783	Protein of unknown function (DUF2804); Region: DUF2804; pfam10974
497978008784	Domain of Unknown Function (DUF1543); Region: DUF1543; pfam07566
497978008785	tryptophan synthase, beta subunit; Region: trpB; TIGR00263
497978008786	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
497978008787	pyridoxal 5'-phosphate binding site [chemical binding]; other site
497978008788	catalytic residue [active]
497978008789	Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405
497978008790	active site
497978008791	Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206
497978008792	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
497978008793	N-terminal plug; other site
497978008794	ligand-binding site [chemical binding]; other site
497978008795	Cobalamin adenosyltransferase; Region: Cob_adeno_trans; pfam01923
497978008796	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
497978008797	Glycerophosphodiester phosphodiesterase domain as found in prokaryota and eukaryota, and similar proteins; Region: GDPD; cd08556
497978008798	active site
497978008799	catalytic site [active]
497978008800	metal binding site [ion binding]; metal-binding site
497978008801	META domain; Region: META; pfam03724
497978008802	The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505
497978008803	Fatty acid desaturase; Region: FA_desaturase; pfam00487
497978008804	Di-iron ligands [ion binding]; other site
497978008805	Uncharacterized conserved protein [Function unknown]; Region: COG0397
497978008806	hypothetical protein; Validated; Region: PRK00029
497978008807	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
497978008808	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
497978008809	active site
497978008810	phosphorylation site [posttranslational modification]
497978008811	intermolecular recognition site; other site
497978008812	dimerization interface [polypeptide binding]; other site
497978008813	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
497978008814	DNA binding site [nucleotide binding]
497978008815	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
497978008816	dimerization interface [polypeptide binding]; other site
497978008817	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
497978008818	dimer interface [polypeptide binding]; other site
497978008819	phosphorylation site [posttranslational modification]
497978008820	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
497978008821	ATP binding site [chemical binding]; other site
497978008822	Mg2+ binding site [ion binding]; other site
497978008823	G-X-G motif; other site
497978008824	Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418
497978008825	acyl-CoA dehydrogenase; Provisional; Region: PTZ00456
497978008826	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
497978008827	active site
497978008828	Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806
497978008829	acyl-CoA dehydrogenase; Provisional; Region: PTZ00456
497978008830	Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418
497978008831	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
497978008832	active site
497978008833	Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806
497978008834	LysR family transcriptional regulator; Provisional; Region: PRK14997
497978008835	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
497978008836	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
497978008837	putative effector binding pocket; other site
497978008838	dimerization interface [polypeptide binding]; other site
497978008839	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
497978008840	GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057
497978008841	C-terminal domain interface [polypeptide binding]; other site
497978008842	GSH binding site (G-site) [chemical binding]; other site
497978008843	dimer interface [polypeptide binding]; other site
497978008844	C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188
497978008845	dimer interface [polypeptide binding]; other site
497978008846	substrate binding pocket (H-site) [chemical binding]; other site
497978008847	N-terminal domain interface [polypeptide binding]; other site
497978008848	Predicted membrane protein [Function unknown]; Region: COG3223
497978008849	Domain of unknown function (DUF3315); Region: DUF3315; pfam11776
497978008850	Putative catalytic domain, repeat 1, of uncharacterized phospholipase D-like proteins; Region: PLDc_unchar2_1; cd09129
497978008851	putative active site [active]
497978008852	putative catalytic site [active]
497978008853	Putative catalytic domain, repeat 2, of uncharacterized phospholipase D-like proteins; Region: PLDc_unchar2_2; cd09130
497978008854	PLD-like domain; Region: PLDc_2; pfam13091
497978008855	putative active site [active]
497978008856	putative catalytic site [active]
497978008857	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
497978008858	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
497978008859	N-terminal plug; other site
497978008860	ligand-binding site [chemical binding]; other site
497978008861	Domain of unknown function (DUF4184); Region: DUF4184; pfam13803
497978008862	aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476
497978008863	EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317
497978008864	dimer interface [polypeptide binding]; other site
497978008865	anticodon binding site; other site
497978008866	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
497978008867	homodimer interface [polypeptide binding]; other site
497978008868	motif 1; other site
497978008869	active site
497978008870	motif 2; other site
497978008871	GAD domain; Region: GAD; pfam02938
497978008872	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
497978008873	active site
497978008874	motif 3; other site
497978008875	Protein of unknown function (DUF3184); Region: DUF3184; pfam11380
497978008876	Glycosyltransferase family 25 [lipooligosaccharide (LOS) biosynthesis protein] is a family of glycosyltransferases involved in LOS biosynthesis. The members include the beta(1,4) galactosyltransferases: Lgt2 of Moraxella catarrhalis, LgtB and LgtE of...; Region: Glyco_transf_25; cd06532
497978008877	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
497978008878	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
497978008879	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
497978008880	UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511
497978008881	putative metal binding site; other site
497978008882	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
497978008883	Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918
497978008884	putative active site [active]
497978008885	putative metal binding site [ion binding]; other site
497978008886	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736
497978008887	phosphorylation site [posttranslational modification]
497978008888	Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524
497978008889	Predicted nucleoside-diphosphate-sugar epimerase [Cell envelope biogenesis, outer membrane]; Region: COG3660
497978008890	Mitochondrial fission ELM1; Region: Mito_fiss_Elm1; pfam06258
497978008891	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
497978008892	BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids  leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557
497978008893	homodimer interface [polypeptide binding]; other site
497978008894	substrate-cofactor binding pocket; other site
497978008895	catalytic residue [active]
497978008896	bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Reviewed; Region: PRK11072
497978008897	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
497978008898	metal binding triad; other site
497978008899	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
497978008900	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
497978008901	metal binding triad; other site
497978008902	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
497978008903	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
497978008904	dimer interface [polypeptide binding]; other site
497978008905	phosphorylation site [posttranslational modification]
497978008906	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
497978008907	ATP binding site [chemical binding]; other site
497978008908	Mg2+ binding site [ion binding]; other site
497978008909	G-X-G motif; other site
497978008910	KAP family P-loop domain; Region: KAP_NTPase; pfam07693
497978008911	Predicted P-loop ATPase [General function prediction only]; Region: COG4928
497978008912	Omega-hydroxypalmitate O-feruloyl transferase; Region: PLN02481; cl03601
497978008913	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147
497978008914	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113
497978008915	LemA family; Region: LemA; cl00742
497978008916	queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112
497978008917	Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343
497978008918	preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585
497978008919	SecD export protein N-terminal TM region; Region: SecD-TM1; pfam13721
497978008920	preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812
497978008921	SecD/SecF GG Motif; Region: Sec_GG; pfam07549
497978008922	protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916
497978008923	preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022
497978008924	SecD/SecF GG Motif; Region: Sec_GG; pfam07549
497978008925	Protein export membrane protein; Region: SecD_SecF; pfam02355
497978008926	bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579
497978008927	Flavoprotein; Region: Flavoprotein; pfam02441
497978008928	DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127
497978008929	hypothetical protein; Reviewed; Region: PRK00024
497978008930	Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
497978008931	MPN+ (JAMM) motif; other site
497978008932	Zinc-binding site [ion binding]; other site
497978008933	Bestrophin, RFP-TM, chloride channel; Region: Bestrophin; pfam01062
497978008934	Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613
497978008935	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438
497978008936	active site
497978008937	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438
497978008938	Intracellular septation protein A; Region: IspA; pfam04279
497978008939	YciI-like protein; Reviewed; Region: PRK11370
497978008940	bifunctional tRNA (mnm(5)s(2)U34)-methyltransferase/FAD-dependent cmnm(5)s(2)U34 oxidoreductase; Reviewed; Region: mnmC; PRK01747
497978008941	Uncharacterized conserved protein [Function unknown]; Region: COG4121
497978008942	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
497978008943	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
497978008944	active site residue [active]
497978008945	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666
497978008946	Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740
497978008947	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
497978008948	CoenzymeA binding site [chemical binding]; other site
497978008949	subunit interaction site [polypeptide binding]; other site
497978008950	PHB binding site; other site
497978008951	Brown fat-inducible thioesterase (BFIT).  Brain acyl-CoA hydrolase (BACH).  These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442
497978008952	thioredoxin 2; Provisional; Region: PRK10996
497978008953	zinc-ribbon domain; Region: zinc_ribbon_5; cl11777
497978008954	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
497978008955	catalytic residues [active]
497978008956	Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073
497978008957	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
497978008958	Putative phosphatase (DUF442); Region: DUF442; cl17385
497978008959	dihydrolipoamide dehydrogenase; Validated; Region: PRK06292
497978008960	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
497978008961	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
497978008962	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
497978008963	Domain of unknown function (DUF4154); Region: DUF4154; pfam13689
497978008964	putative inner membrane diguanylate cyclase; Provisional; Region: PRK09966
497978008965	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
497978008966	metal binding site [ion binding]; metal-binding site
497978008967	active site
497978008968	I-site; other site
497978008969	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
497978008970	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
497978008971	ligand binding site [chemical binding]; other site
497978008972	phosphodiesterase YaeI; Provisional; Region: PRK11340
497978008973	Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385
497978008974	putative active site [active]
497978008975	putative metal binding site [ion binding]; other site
497978008976	Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502
497978008977	Putative catalytic domain, repeat 1, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_1; cd09111
497978008978	putative active site [active]
497978008979	catalytic site [active]
497978008980	Putative catalytic domain, repeat 2, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_2; cd09113
497978008981	putative active site [active]
497978008982	catalytic site [active]
497978008983	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
497978008984	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
497978008985	putative acyl-acceptor binding pocket; other site
497978008986	GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167
497978008987	GTP-binding protein HflX; Region: GTP_HflX; TIGR03156
497978008988	HflX GTPase family; Region: HflX; cd01878
497978008989	G1 box; other site
497978008990	GTP/Mg2+ binding site [chemical binding]; other site
497978008991	Switch I region; other site
497978008992	G2 box; other site
497978008993	G3 box; other site
497978008994	Switch II region; other site
497978008995	G4 box; other site
497978008996	G5 box; other site
497978008997	LrgB-like family; Region: LrgB; cl00596
497978008998	Uncharacterized protein conserved in bacteria (DUF2147); Region: DUF2147; pfam09917
497978008999	diadenosine tetraphosphatase; Reviewed; Region: apaH; PRK00166
497978009000	Escherichia coli ApaH and related proteins, metallophosphatase domain; Region: MPP_ApaH; cd07422
497978009001	active site
497978009002	metal binding site [ion binding]; metal-binding site
497978009003	16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274
497978009004	Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030
497978009005	4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743
497978009006	4-hydroxythreonine-4-phosphate dehydrogenase; Region: pdxA; TIGR00557
497978009007	Ribosomal protein L13.  Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392
497978009008	23S rRNA interface [nucleotide binding]; other site
497978009009	L3 interface [polypeptide binding]; other site
497978009010	30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132
497978009011	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
497978009012	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
497978009013	C-terminal, alpha helical domain of Stringent starvation protein A; Region: GST_C_SspA; cd03186
497978009014	dimer interface [polypeptide binding]; other site
497978009015	N-terminal domain interface [polypeptide binding]; other site
497978009016	ClpXP protease specificity-enhancing factor; Provisional; Region: PRK11798
497978009017	Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770
497978009018	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
497978009019	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
497978009020	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785
497978009021	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
497978009022	carboxyltransferase (CT) interaction site; other site
497978009023	biotinylation site [posttranslational modification]; other site
497978009024	enoyl-CoA hydratase; Provisional; Region: PRK05995
497978009025	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
497978009026	substrate binding site [chemical binding]; other site
497978009027	oxyanion hole (OAH) forming residues; other site
497978009028	trimer interface [polypeptide binding]; other site
497978009029	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
497978009030	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
497978009031	active site
497978009032	Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799
497978009033	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
497978009034	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
497978009035	Trans-2-enoyl-CoA reductase (TER) and 2,4-dienoyl-CoA reductase (DECR), atypical (a) SDR; Region: TER_DECR_SDR_a; cd05369
497978009036	NAD(P) binding site [chemical binding]; other site
497978009037	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
497978009038	substrate binding site [chemical binding]; other site
497978009039	homotetramer interface [polypeptide binding]; other site
497978009040	active site
497978009041	homodimer interface [polypeptide binding]; other site
497978009042	Protein of unknown function (DUF1446); Region: DUF1446; pfam07287
497978009043	RUN domain; Region: RUN; cl02689
497978009044	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
497978009045	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
497978009046	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
497978009047	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
497978009048	active site
497978009049	Protein of unknown function (DUF4256); Region: DUF4256; pfam14066
497978009050	Domain of unknown function (DUF2007); Region: DUF2007; pfam09413
497978009051	Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183
497978009052	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066
497978009053	Protein involved in catabolism of external DNA [General function prediction only]; Region: ComJ; COG2961
497978009054	Predicted proline hydroxylase [Posttranslational modification, protein turnover, chaperones]; Region: EGL-9; COG3751
497978009055	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; pfam13640
497978009056	Protein of unknown function (DUF2789); Region: DUF2789; pfam10982
497978009057	malate dehydrogenase; Provisional; Region: PRK05442
497978009058	Chloroplast-like malate dehydrogenases; Region: MDH_choloroplast_like; cd01338
497978009059	NAD(P) binding site [chemical binding]; other site
497978009060	dimer interface [polypeptide binding]; other site
497978009061	malate binding site [chemical binding]; other site
497978009062	Ribonuclease T2 (RNase T2) is a widespread family of secreted RNases found in every organism examined thus far.  This family includes RNase Rh, RNase MC1, RNase LE, and self-incompatibility RNases (S-RNases).  Plant T2 RNases are expressed during leaf...; Region: RNase_T2_prok; cd01062
497978009063	B1 nucleotide binding pocket [chemical binding]; other site
497978009064	B2 nucleotide binding pocket [chemical binding]; other site
497978009065	CAS motifs; other site
497978009066	active site
497978009067	lytic murein transglycosylase; Provisional; Region: PRK11619
497978009068	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
497978009069	N-acetyl-D-glucosamine binding site [chemical binding]; other site
497978009070	catalytic residue [active]
497978009071	(dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325
497978009072	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
497978009073	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
497978009074	FeS/SAM binding site; other site
497978009075	TRAM domain; Region: TRAM; cl01282
497978009076	Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702
497978009077	PhoH-like protein; Region: PhoH; pfam02562
497978009078	metal-binding heat shock protein; Provisional; Region: PRK00016
497978009079	Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810
497978009080	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
497978009081	Protein of unknown function (DUF3108); Region: DUF3108; pfam11306
497978009082	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
497978009083	active site
497978009084	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
497978009085	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
497978009086	Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918
497978009087	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
497978009088	EamA-like transporter family; Region: EamA; pfam00892
497978009089	Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730
497978009090	Helix-turn-helix domain; Region: HTH_18; pfam12833
497978009091	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
497978009092	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
497978009093	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421
497978009094	YcxB-like protein; Region: YcxB; pfam14317
497978009095	Nitroreductase-like family 4.  A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_4; cd02140
497978009096	dimer interface [polypeptide binding]; other site
497978009097	FMN binding site [chemical binding]; other site
497978009098	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
497978009099	ribonuclease R; Region: RNase_R; TIGR02063
497978009100	RNB domain; Region: RNB; pfam00773
497978009101	S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471
497978009102	RNA binding site [nucleotide binding]; other site
497978009103	Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339
497978009104	Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456
497978009105	active site
497978009106	Zn binding site [ion binding]; other site
497978009107	Probable metal-binding protein (DUF2387); Region: DUF2387; pfam09526
497978009108	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274
497978009109	rhomboid family GlyGly-CTERM serine protease; Region: rhom_GG_sort; TIGR03902
497978009110	Flavinator of succinate dehydrogenase; Region: Sdh5; pfam03937
497978009111	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
497978009112	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
497978009113	active site
497978009114	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
497978009115	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
497978009116	50S ribosomal protein L17; Validated; Region: rplQ; PRK05591
497978009117	DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182
497978009118	N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928
497978009119	alphaNTD homodimer interface [polypeptide binding]; other site
497978009120	alphaNTD - beta interaction site [polypeptide binding]; other site
497978009121	alphaNTD - beta' interaction site [polypeptide binding]; other site
497978009122	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118
497978009123	30S ribosomal protein S4; Validated; Region: rpsD; PRK05327
497978009124	Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163
497978009125	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
497978009126	RNA binding surface [nucleotide binding]; other site
497978009127	30S ribosomal protein S11; Validated; Region: PRK05309
497978009128	30S ribosomal protein S13; Validated; Region: rpsM; PRK05179
497978009129	30S ribosomal protein S13; Region: bact_S13; TIGR03631
497978009130	Ribosomal protein L36; Region: Ribosomal_L36; pfam00444
497978009131	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204
497978009132	SecY translocase; Region: SecY; pfam00344
497978009133	50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592
497978009134	Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658
497978009135	23S rRNA binding site [nucleotide binding]; other site
497978009136	30S ribosomal protein S5; Validated; Region: rpsE; PRK00550
497978009137	Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333
497978009138	Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719
497978009139	Ribosomal L18/L5e:  L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432
497978009140	5S rRNA interface [nucleotide binding]; other site
497978009141	23S rRNA interface [nucleotide binding]; other site
497978009142	L5 interface [polypeptide binding]; other site
497978009143	50S ribosomal protein L6; Validated; Region: rplF; PRK05498
497978009144	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
497978009145	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
497978009146	30S ribosomal protein S8; Validated; Region: rpsH; PRK00136
497978009147	30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881
497978009148	50S ribosomal protein L5; Validated; Region: rplE; PRK00010
497978009149	Ribosomal protein L5; Region: Ribosomal_L5; pfam00281
497978009150	ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673
497978009151	50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004
497978009152	KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089
497978009153	RNA binding site [nucleotide binding]; other site
497978009154	50S ribosomal protein L14; Validated; Region: rplN; PRK05483
497978009155	30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610
497978009156	Ribosomal L29 protein/HIP.  L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals.  L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427
497978009157	23S rRNA interface [nucleotide binding]; other site
497978009158	putative translocon interaction site; other site
497978009159	signal recognition particle (SRP54) interaction site; other site
497978009160	L23 interface [polypeptide binding]; other site
497978009161	trigger factor interaction site; other site
497978009162	Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433
497978009163	23S rRNA interface [nucleotide binding]; other site
497978009164	5S rRNA interface [nucleotide binding]; other site
497978009165	putative antibiotic binding site [chemical binding]; other site
497978009166	L25 interface [polypeptide binding]; other site
497978009167	L27 interface [polypeptide binding]; other site
497978009168	30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310
497978009169	K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3  is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel.  The KH...; Region: 30S_S3_KH; cd02412
497978009170	G-X-X-G motif; other site
497978009171	Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189
497978009172	Ribosomal protein L22/L17e.  L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit.  It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336
497978009173	putative translocon binding site; other site
497978009174	protein-rRNA interface [nucleotide binding]; other site
497978009175	30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357
497978009176	50S ribosomal protein L2; Validated; Region: rplB; PRK09374
497978009177	Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181
497978009178	Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947
497978009179	50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738
497978009180	50S ribosomal protein L4; Provisional; Region: rplD; PRK05319
497978009181	50S ribosomal protein L3; Validated; Region: rplC; PRK00001
497978009182	30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596
497978009183	GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518
497978009184	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741
497978009185	catalytic triad [active]
497978009186	cystathionine beta-lyase; Provisional; Region: PRK07050
497978009187	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
497978009188	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
497978009189	catalytic residue [active]
497978009190	Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872
497978009191	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
497978009192	Walker A motif; other site
497978009193	ATP binding site [chemical binding]; other site
497978009194	Walker B motif; other site
497978009195	Zonular occludens toxin (Zot); Region: Zot; cl17485
497978009196	Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040
497978009197	heme-binding site [chemical binding]; other site
497978009198	Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868
497978009199	FAD binding pocket [chemical binding]; other site
497978009200	conserved FAD binding motif [chemical binding]; other site
497978009201	phosphate binding motif [ion binding]; other site
497978009202	Transcriptional regulator; Region: Rrf2; cl17282
497978009203	Rrf2 family protein; Region: rrf2_super; TIGR00738
497978009204	YihA (EngB) GTPase family; Region: YihA_EngB; cd01876
497978009205	G1 box; other site
497978009206	GTP/Mg2+ binding site [chemical binding]; other site
497978009207	Switch I region; other site
497978009208	G2 box; other site
497978009209	G3 box; other site
497978009210	Switch II region; other site
497978009211	G4 box; other site
497978009212	G5 box; other site
497978009213	Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687
497978009214	Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118
497978009215	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
497978009216	Sodium:dicarboxylate symporter family; Region: SDF; pfam00375
497978009217	Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946
497978009218	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445
497978009219	active site
497978009220	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444
497978009221	catalytic triad [active]
497978009222	dimer interface [polypeptide binding]; other site
497978009223	glycerol-3-phosphate O-acyltransferase; Region: plsB; TIGR03703
497978009224	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Region: LPLAT_DHAPAT-like; cd07993
497978009225	putative acyl-acceptor binding pocket; other site
497978009226	lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096
497978009227	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
497978009228	NADH(P)-binding; Region: NAD_binding_10; pfam13460
497978009229	NAD(P) binding site [chemical binding]; other site
497978009230	active site
497978009231	ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917
497978009232	RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488
497978009233	ssDNA binding site; other site
497978009234	generic binding surface II; other site
497978009235	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
497978009236	ATP binding site [chemical binding]; other site
497978009237	putative Mg++ binding site [ion binding]; other site
497978009238	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
497978009239	nucleotide binding region [chemical binding]; other site
497978009240	ATP-binding site [chemical binding]; other site
497978009241	comF family protein; Region: comF; TIGR00201
497978009242	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
497978009243	active site
497978009244	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_31; cd04690
497978009245	nudix motif; other site
497978009246	Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695
497978009247	Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598
497978009248	Escherichia coli Mg2+ transporter CorA_like subgroup; Region: EcCorA-like_1; cd12835
497978009249	Cl binding site [ion binding]; other site
497978009250	oligomer interface [polypeptide binding]; other site
497978009251	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
497978009252	anti sigma factor interaction site; other site
497978009253	regulatory phosphorylation site [posttranslational modification]; other site
497978009254	Toluene tolerance, Ttg2; Region: Tol_Tol_Ttg2; pfam05494
497978009255	ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463
497978009256	mce related protein; Region: MCE; pfam02470
497978009257	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
497978009258	Permease; Region: Permease; cl00510
497978009259	ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127
497978009260	ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261
497978009261	Walker A/P-loop; other site
497978009262	ATP binding site [chemical binding]; other site
497978009263	Q-loop/lid; other site
497978009264	ABC transporter signature motif; other site
497978009265	Walker B; other site
497978009266	D-loop; other site
497978009267	H-loop/switch region; other site
497978009268	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
497978009269	DEAD-like helicases superfamily; Region: DEXDc; smart00487
497978009270	ATP binding site [chemical binding]; other site
497978009271	Mg++ binding site [ion binding]; other site
497978009272	motif III; other site
497978009273	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
497978009274	nucleotide binding region [chemical binding]; other site
497978009275	ATP-binding site [chemical binding]; other site
497978009276	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
497978009277	IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639
497978009278	active site
497978009279	dimerization interface [polypeptide binding]; other site
497978009280	1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444
497978009281	Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007
497978009282	TPP-binding site; other site
497978009283	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
497978009284	PYR/PP interface [polypeptide binding]; other site
497978009285	dimer interface [polypeptide binding]; other site
497978009286	TPP binding site [chemical binding]; other site
497978009287	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
497978009288	GTP cyclohydrolase II (RibA).  GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641
497978009289	dimerization interface [polypeptide binding]; other site
497978009290	active site
497978009291	coproporphyrinogen III oxidase; Provisional; Region: PRK05330
497978009292	Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; pfam01218
497978009293	shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258
497978009294	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
497978009295	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
497978009296	shikimate binding site; other site
497978009297	NAD(P) binding site [chemical binding]; other site
497978009298	Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418
497978009299	acyl-CoA dehydrogenase; Provisional; Region: PTZ00456
497978009300	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
497978009301	active site
497978009302	Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806
497978009303	hypothetical protein; Provisional; Region: PRK11615
497978009304	PspC domain; Region: PspC; pfam04024
497978009305	CBS-domain-containing membrane protein [Signal transduction mechanisms]; Region: COG3448
497978009306	HPP family; Region: HPP; pfam04982
497978009307	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
497978009308	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the HPP motif domain. These proteins are integral membrane proteins with four transmembrane spanning helices. The function of these proteins is...; Region: CBS_pair_HPP_assoc; cd04600
497978009309	probable DNA metabolism protein; Region: SAM_7_link_chp; TIGR03915
497978009310	putative DNA modification/repair radical SAM protein; Region: rSAM_link_UDG; TIGR03916
497978009311	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
497978009312	FeS/SAM binding site; other site
497978009313	Protein of unknown function (DUF1311); Region: DUF1311; pfam07007
497978009314	Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733
497978009315	dimer interface [polypeptide binding]; other site
497978009316	motif 1; other site
497978009317	active site
497978009318	motif 2; other site
497978009319	motif 3; other site
497978009320	glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233
497978009321	YCII-related domain; Region: YCII; cl00999
497978009322	EamA-like transporter family; Region: EamA; pfam00892
497978009323	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
497978009324	EamA-like transporter family; Region: EamA; pfam00892
497978009325	Transcriptional regulator [Transcription]; Region: LysR; COG0583
497978009326	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
497978009327	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
497978009328	dimerization interface [polypeptide binding]; other site
497978009329	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459
497978009330	active site
497978009331	catalytic residues [active]
497978009332	Peptidase M14 Succinylglutamate desuccinylase (ASTE) subfamily; Region: M14_ASTE; cd03855
497978009333	Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952
497978009334	putative active site [active]
497978009335	Zn binding site [ion binding]; other site
497978009336	succinylarginine dihydrolase; Provisional; Region: PRK13281
497978009337	succinylglutamic semialdehyde dehydrogenase; Reviewed; Region: astD; PRK09457
497978009338	N-succinylglutamate 5-semialdehyde dehydrogenase, AstD-like; Region: ALDH_SGSD_AstD; cd07095
497978009339	NAD(P) binding site [chemical binding]; other site
497978009340	catalytic residues [active]
497978009341	Arginine/ornithine N-succinyltransferase beta subunit [Amino acid transport and metabolism]; Region: AstA; COG3138
497978009342	Arginine N-succinyltransferase beta subunit; Region: AstA; cl11440
497978009343	bifunctional succinylornithine transaminase/acetylornithine transaminase; Provisional; Region: PRK12381
497978009344	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
497978009345	inhibitor-cofactor binding pocket; inhibition site
497978009346	pyridoxal 5'-phosphate binding site [chemical binding]; other site
497978009347	catalytic residue [active]
497978009348	Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334
497978009349	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
497978009350	NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076
497978009351	NAD(P) binding site [chemical binding]; other site
497978009352	S-methylmethionine transporter; Provisional; Region: PRK11387
497978009353	Methyltransferase domain; Region: Methyltransf_23; pfam13489
497978009354	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
497978009355	S-adenosylmethionine binding site [chemical binding]; other site
497978009356	Endonuclease related to archaeal Holliday junction resolvase; Region: Endonuc_Holl; cl01958
497978009357	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
497978009358	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
497978009359	P-loop; other site
497978009360	Magnesium ion binding site [ion binding]; other site
497978009361	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
497978009362	Domain of unknown function DUF20; Region: UPF0118; pfam01594
497978009363	Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032
497978009364	Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305
497978009365	E-class dimer interface [polypeptide binding]; other site
497978009366	P-class dimer interface [polypeptide binding]; other site
497978009367	active site
497978009368	Cu2+ binding site [ion binding]; other site
497978009369	Zn2+ binding site [ion binding]; other site
497978009370	FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805
497978009371	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
497978009372	multidrug efflux system translocase MdfA; Provisional; Region: PRK15402
497978009373	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
497978009374	putative substrate translocation pore; other site
497978009375	Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249
497978009376	Uncharacterized conserved protein [Function unknown]; Region: COG1359
497978009377	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
497978009378	FAD binding domain; Region: FAD_binding_4; pfam01565
497978009379	D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790
497978009380	Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_3; cd12176
497978009381	ligand binding site [chemical binding]; other site
497978009382	NAD binding site [chemical binding]; other site
497978009383	tetramer interface [polypeptide binding]; other site
497978009384	catalytic site [active]
497978009385	C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901
497978009386	L-serine binding site [chemical binding]; other site
497978009387	ACT domain interface; other site
497978009388	threonine and homoserine efflux system; Provisional; Region: PRK10532
497978009389	EamA-like transporter family; Region: EamA; pfam00892
497978009390	Threonine/homoserine efflux transporter [Amino acid transport and metabolism]; Region: rhtA; COG5006
497978009391	Hemerythrin-like domain; Region: Hr-like; cd12108
497978009392	hypothetical protein; Provisional; Region: PRK10621
497978009393	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
497978009394	tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05033
497978009395	Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573
497978009396	RNA binding site [nucleotide binding]; other site
497978009397	active site
497978009398	Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157
497978009399	lipase chaperone; Provisional; Region: PRK01294
497978009400	Proteobacterial lipase chaperone protein; Region: Lipase_chap; pfam03280
497978009401	Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075
497978009402	Putative serine esterase (DUF676); Region: DUF676; pfam05057
497978009403	50S ribosomal protein L19; Provisional; Region: rplS; PRK05338
497978009404	tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026
497978009405	16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122
497978009406	RimM N-terminal domain; Region: RimM; pfam01782
497978009407	PRC-barrel domain; Region: PRC; pfam05239
497978009408	30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040
497978009409	Tfp pilus assembly protein PilE [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilE; COG4968
497978009410	Tfp pilus assembly protein PilE [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilE; COG4968
497978009411	von Willebrand factor type A domain; Region: VWA_2; pfam13519
497978009412	Neisseria PilC beta-propeller domain; Region: Neisseria_PilC; pfam05567
497978009413	type IV pilus modification protein PilV; Region: type_IV_pilV; TIGR02523
497978009414	Tfp pilus assembly protein FimT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimT; COG4970
497978009415	4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045
497978009416	4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761
497978009417	Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194
497978009418	Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071
497978009419	catalytic site [active]
497978009420	G-X2-G-X-G-K; other site
497978009421	DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392
497978009422	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
497978009423	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
497978009424	Zn2+ binding site [ion binding]; other site
497978009425	Mg2+ binding site [ion binding]; other site
497978009426	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
497978009427	synthetase active site [active]
497978009428	NTP binding site [chemical binding]; other site
497978009429	metal binding site [ion binding]; metal-binding site
497978009430	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
497978009431	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
497978009432	ACT domain; Region: ACT_4; pfam13291
497978009433	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
497978009434	homotrimer interaction site [polypeptide binding]; other site
497978009435	putative active site [active]
497978009436	Bacterioferritin-associated ferredoxin [Inorganic ion transport and metabolism]; Region: Bfd; COG2906
497978009437	Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193
497978009438	Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907
497978009439	heme binding site [chemical binding]; other site
497978009440	ferroxidase pore; other site
497978009441	ferroxidase diiron center [ion binding]; other site
497978009442	Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307
497978009443	O-Antigen ligase; Region: Wzy_C; pfam04932
497978009444	Domain of unknown function (DUF3366); Region: DUF3366; pfam11846
497978009445	O-antigen ligase like membrane protein; Region: O-antigen_lig; pfam13425
497978009446	Tfp pilus assembly protein, major pilin PilA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilA; COG4969
497978009447	Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544
497978009448	Pilin (bacterial filament); Region: Pilin; pfam00114
497978009449	Repair protein; Region: Repair_PSII; pfam04536
497978009450	Repair protein; Region: Repair_PSII; pfam04536
497978009451	LemA family; Region: LemA; pfam04011
497978009452	Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687
497978009453	Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118
497978009454	glutamate synthase small subunit family protein, proteobacterial; Region: gltD_gamma_fam; TIGR01318
497978009455	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
497978009456	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
497978009457	glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750
497978009458	Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713
497978009459	active site
497978009460	dimer interface [polypeptide binding]; other site
497978009461	Glutamate synthase central domain; Region: Glu_syn_central; pfam04898
497978009462	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
497978009463	active site
497978009464	FMN binding site [chemical binding]; other site
497978009465	substrate binding site [chemical binding]; other site
497978009466	3Fe-4S cluster binding site [ion binding]; other site
497978009467	gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982
497978009468	domain interface; other site
497978009469	Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195
497978009470	active site
497978009471	dimer interface [polypeptide binding]; other site
497978009472	metal binding site [ion binding]; metal-binding site
497978009473	shikimate kinase; Reviewed; Region: aroK; PRK00131
497978009474	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
497978009475	ADP binding site [chemical binding]; other site
497978009476	magnesium binding site [ion binding]; other site
497978009477	putative shikimate binding site; other site
497978009478	AMIN domain; Region: AMIN; pfam11741
497978009479	type IV pilus secretin (or competence protein) PilQ; Region: IV_pilus_PilQ; TIGR02515
497978009480	Secretin and TonB N terminus short domain; Region: STN; smart00965
497978009481	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
497978009482	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
497978009483	Tfp pilus assembly protein PilP [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilP; COG3168
497978009484	Pilus assembly protein, PilP; Region: PilP; pfam04351
497978009485	Pilus assembly protein, PilO; Region: PilO; pfam04350
497978009486	Tfp pilus assembly protein PilN [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilN; COG3166
497978009487	Fimbrial assembly protein (PilN); Region: PilN; pfam05137
497978009488	Competence protein A; Region: Competence_A; pfam11104
497978009489	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
497978009490	Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane]; Region: MrcA; COG5009
497978009491	Transglycosylase; Region: Transgly; pfam00912
497978009492	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
497978009493	23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088
497978009494	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
497978009495	S-adenosylmethionine binding site [chemical binding]; other site
497978009496	phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108
497978009497	Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852
497978009498	Mg++ binding site [ion binding]; other site
497978009499	putative catalytic motif [active]
497978009500	putative substrate binding site [chemical binding]; other site
497978009501	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
497978009502	UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Region: murF; TIGR01143
497978009503	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
497978009504	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
497978009505	UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139
497978009506	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
497978009507	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
497978009508	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
497978009509	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
497978009510	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
497978009511	Cell division protein FtsL; Region: FtsL; pfam04999
497978009512	16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050
497978009513	MraW methylase family; Region: Methyltransf_5; cl17771
497978009514	ABC-type sulfate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: Sbp; COG1613
497978009515	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
497978009516	glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
497978009517	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
497978009518	active site
497978009519	HIGH motif; other site
497978009520	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
497978009521	active site
497978009522	KMSKS motif; other site
497978009523	S-methylmethionine transporter; Provisional; Region: PRK11387
497978009524	Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230
497978009525	heavy metal efflux pump, CzcA family; Region: 2A0601; TIGR00914
497978009526	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
497978009527	Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999
497978009528	HlyD family secretion protein; Region: HlyD_3; pfam13437
497978009529	Outer membrane efflux protein; Region: OEP; pfam02321
497978009530	Outer membrane efflux protein; Region: OEP; pfam02321
497978009531	Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020
497978009532	hypothetical protein; Provisional; Region: PRK10215
497978009533	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
497978009534	Sel1-like repeats; Region: SEL1; smart00671
497978009535	putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819
497978009536	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
497978009537	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
497978009538	ABC transporter; Region: ABC_tran_2; pfam12848
497978009539	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
497978009540	O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK06084
497978009541	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
497978009542	homodimer interface [polypeptide binding]; other site
497978009543	substrate-cofactor binding pocket; other site
497978009544	pyridoxal 5'-phosphate binding site [chemical binding]; other site
497978009545	catalytic residue [active]
497978009546	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
497978009547	classical (c) SDRs; Region: SDR_c; cd05233
497978009548	NAD(P) binding site [chemical binding]; other site
497978009549	active site
497978009550	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
497978009551	Sulfate transporter family; Region: Sulfate_transp; pfam00916
497978009552	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378
497978009553	active site clefts [active]
497978009554	zinc binding site [ion binding]; other site
497978009555	dimer interface [polypeptide binding]; other site
497978009556	Transcriptional accessory protein [Transcription]; Region: Tex; COG2183
497978009557	Tex-like protein N-terminal domain; Region: Tex_N; pfam09371
497978009558	Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732
497978009559	S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685
497978009560	RNA binding site [nucleotide binding]; other site
497978009561	osmolarity response regulator; Provisional; Region: ompR; PRK09468
497978009562	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
497978009563	active site
497978009564	phosphorylation site [posttranslational modification]
497978009565	intermolecular recognition site; other site
497978009566	dimerization interface [polypeptide binding]; other site
497978009567	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
497978009568	DNA binding site [nucleotide binding]
497978009569	osmolarity sensor protein; Provisional; Region: envZ; PRK09467
497978009570	HAMP domain; Region: HAMP; pfam00672
497978009571	dimerization interface [polypeptide binding]; other site
497978009572	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
497978009573	dimer interface [polypeptide binding]; other site
497978009574	phosphorylation site [posttranslational modification]
497978009575	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
497978009576	ATP binding site [chemical binding]; other site
497978009577	Mg2+ binding site [ion binding]; other site
497978009578	G-X-G motif; other site
497978009579	Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550
497978009580	succinate CoA transferase; Region: YgfH_subfam; TIGR03458
497978009581	Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336
497978009582	putative acetyltransferase; Provisional; Region: PRK03624
497978009583	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
497978009584	Coenzyme A binding pocket [chemical binding]; other site
497978009585	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
497978009586	Coenzyme A binding pocket [chemical binding]; other site
497978009587	Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914
497978009588	putative active site pocket [active]
497978009589	4-fold oligomerization interface [polypeptide binding]; other site
497978009590	metal binding residues [ion binding]; metal-binding site
497978009591	3-fold/trimer interface [polypeptide binding]; other site
497978009592	imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141
497978009593	Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748
497978009594	putative active site [active]
497978009595	oxyanion strand; other site
497978009596	catalytic triad [active]
497978009597	Protein of unknown function (DUF805); Region: DUF805; pfam05656
497978009598	DEDDy 3'-5' exonuclease domain of WRN and similar proteins; Region: WRN_exo; cd06141
497978009599	catalytic site [active]
497978009600	putative active site [active]
497978009601	putative substrate binding site [chemical binding]; other site
497978009602	HisA.  Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732
497978009603	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
497978009604	catalytic residues [active]
497978009605	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
497978009606	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
497978009607	non-specific DNA binding site [nucleotide binding]; other site
497978009608	salt bridge; other site
497978009609	sequence-specific DNA binding site [nucleotide binding]; other site
497978009610	EamA-like transporter family; Region: EamA; pfam00892
497978009611	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
497978009612	Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329
497978009613	Predicted membrane protein [Function unknown]; Region: COG3671
497978009614	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
497978009615	DNA-binding site [nucleotide binding]; DNA binding site
497978009616	RNA-binding motif; other site
497978009617	Protein of unknown function (DUF1294); Region: DUF1294; pfam06961
497978009618	Homoserine Kinase, type II. Homoserine kinase is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and...; Region: HomoserineK_II; cd05153
497978009619	Phosphotransferase enzyme family; Region: APH; pfam01636
497978009620	putative active site [active]
497978009621	putative substrate binding site [chemical binding]; other site
497978009622	ATP binding site [chemical binding]; other site
497978009623	The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731
497978009624	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
497978009625	substrate binding site [chemical binding]; other site
497978009626	glutamase interaction surface [polypeptide binding]; other site
497978009627	Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625
497978009628	Helix-turn-helix domain; Region: HTH_18; pfam12833
497978009629	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
497978009630	Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333
497978009631	amphipathic channel; other site
497978009632	Asn-Pro-Ala signature motifs; other site
497978009633	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
497978009634	DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases.  They exists as monomers and homodimers; Region: NUC; cd00091
497978009635	DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892
497978009636	active site
497978009637	substrate binding site [chemical binding]; other site
497978009638	Mg2+ binding site [ion binding]; other site
497978009639	K+ transporter [Inorganic ion transport and metabolism]; Region: Kup; COG3158
497978009640	potassium uptake protein; Region: kup; TIGR00794
497978009641	Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525
497978009642	Predicted transcriptional regulators [Transcription]; Region: COG1733
497978009643	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
497978009644	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
497978009645	Sel1-like repeats; Region: SEL1; smart00671
497978009646	Sel1 repeat; Region: Sel1; cl02723
497978009647	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
497978009648	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
497978009649	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
497978009650	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
497978009651	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
497978009652	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
497978009653	active site
497978009654	catalytic tetrad [active]
497978009655	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
497978009656	EamA-like transporter family; Region: EamA; pfam00892
497978009657	DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906
497978009658	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
497978009659	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
497978009660	dimerization interface [polypeptide binding]; other site
497978009661	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
497978009662	putative substrate translocation pore; other site
497978009663	Major Facilitator Superfamily; Region: MFS_1; pfam07690
497978009664	Major Facilitator Superfamily; Region: MFS_1; pfam07690
497978009665	Uncharacterized conserved protein [Function unknown]; Region: COG3791
497978009666	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
497978009667	S-adenosylmethionine binding site [chemical binding]; other site
497978009668	Predicted NAD/FAD-binding protein [General function prediction only]; Region: COG2907
497978009669	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
497978009670	Pirin-related protein [General function prediction only]; Region: COG1741
497978009671	Pirin; Region: Pirin; pfam02678
497978009672	Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726
497978009673	Isochorismatase family; Region: Isochorismatase; pfam00857
497978009674	YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012
497978009675	catalytic triad [active]
497978009676	dimer interface [polypeptide binding]; other site
497978009677	conserved cis-peptide bond; other site
497978009678	LysR family transcriptional regulator; Provisional; Region: PRK14997
497978009679	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
497978009680	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
497978009681	dimerization interface [polypeptide binding]; other site
497978009682	succinic semialdehyde dehydrogenase; Region: PLN02278
497978009683	Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103
497978009684	tetramerization interface [polypeptide binding]; other site
497978009685	NAD(P) binding site [chemical binding]; other site
497978009686	catalytic residues [active]
497978009687	4-aminobutyrate aminotransferase; Provisional; Region: PRK06777
497978009688	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
497978009689	inhibitor-cofactor binding pocket; inhibition site
497978009690	pyridoxal 5'-phosphate binding site [chemical binding]; other site
497978009691	catalytic residue [active]
497978009692	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
497978009693	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
497978009694	DNA-binding site [nucleotide binding]; DNA binding site
497978009695	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
497978009696	pyridoxal 5'-phosphate binding site [chemical binding]; other site
497978009697	homodimer interface [polypeptide binding]; other site
497978009698	catalytic residue [active]
497978009699	gamma-aminobutyrate permease; Region: GABAperm; TIGR01773
497978009700	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
497978009701	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
497978009702	non-specific DNA binding site [nucleotide binding]; other site
497978009703	salt bridge; other site
497978009704	sequence-specific DNA binding site [nucleotide binding]; other site
497978009705	Cupin domain; Region: Cupin_2; pfam07883
497978009706	AzlC protein; Region: AzlC; cl00570
497978009707	Branched-chain amino acid transport protein (AzlD); Region: AzlD; pfam05437
497978009708	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
497978009709	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
497978009710	dimer interface [polypeptide binding]; other site
497978009711	ssDNA binding site [nucleotide binding]; other site
497978009712	tetramer (dimer of dimers) interface [polypeptide binding]; other site
497978009713	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
497978009714	Major Facilitator Superfamily; Region: MFS_1; pfam07690
497978009715	putative substrate translocation pore; other site
497978009716	hypothetical protein; Provisional; Region: PRK14013
497978009717	GlpM protein; Region: GlpM; pfam06942
497978009718	Protein of unknown function (DUF1304); Region: DUF1304; pfam06993
497978009719	2-enoyl thioester reductase (ETR) like proteins, child 2; Region: ETR_like_2; cd08292
497978009720	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
497978009721	putative NAD(P) binding site [chemical binding]; other site
497978009722	putative dimer interface [polypeptide binding]; other site
497978009723	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
497978009724	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
497978009725	excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349
497978009726	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
497978009727	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
497978009728	ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271
497978009729	KAP family P-loop domain; Region: KAP_NTPase; pfam07693
497978009730	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
497978009731	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
497978009732	metal binding site [ion binding]; metal-binding site
497978009733	active site
497978009734	I-site; other site
497978009735	BCCT family transporter; Region: BCCT; pfam02028
497978009736	Predicted symporter [General function prediction only]; Region: DhlC; COG4147
497978009737	Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480
497978009738	Na binding site [ion binding]; other site
497978009739	Protein of unknown function, DUF485; Region: DUF485; pfam04341
497978009740	Na+/proline symporter [Amino acid transport and metabolism / General function prediction only]; Region: PutP; COG0591
497978009741	Na binding site [ion binding]; other site
497978009742	PAS fold; Region: PAS_7; pfam12860
497978009743	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
497978009744	putative active site [active]
497978009745	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
497978009746	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
497978009747	dimer interface [polypeptide binding]; other site
497978009748	phosphorylation site [posttranslational modification]
497978009749	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
497978009750	ATP binding site [chemical binding]; other site
497978009751	Mg2+ binding site [ion binding]; other site
497978009752	G-X-G motif; other site
497978009753	Response regulator receiver domain; Region: Response_reg; pfam00072
497978009754	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
497978009755	active site
497978009756	phosphorylation site [posttranslational modification]
497978009757	intermolecular recognition site; other site
497978009758	dimerization interface [polypeptide binding]; other site
497978009759	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
497978009760	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
497978009761	active site
497978009762	phosphorylation site [posttranslational modification]
497978009763	intermolecular recognition site; other site
497978009764	dimerization interface [polypeptide binding]; other site
497978009765	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
497978009766	DNA binding residues [nucleotide binding]
497978009767	dimerization interface [polypeptide binding]; other site
497978009768	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
497978009769	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
497978009770	dimethyl sulfone monooxygenase SfnG; Region: LLM_DMSO2_sfnG; TIGR04021
497978009771	Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094
497978009772	active site
497978009773	dimer interface [polypeptide binding]; other site
497978009774	non-prolyl cis peptide bond; other site
497978009775	insertion regions; other site
497978009776	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328
497978009777	MULE transposase domain; Region: MULE; pfam10551
497978009778	helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344
497978009779	AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404
497978009780	dimerization interface [polypeptide binding]; other site
497978009781	putative DNA binding site [nucleotide binding]; other site
497978009782	putative Zn2+ binding site [ion binding]; other site
497978009783	AsnC family; Region: AsnC_trans_reg; pfam01037
497978009784	Isochorismatase family; Region: Isochorismatase; pfam00857
497978009785	Nicotinamidase_ related amidohydrolases.  Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014
497978009786	catalytic triad [active]
497978009787	conserved cis-peptide bond; other site
497978009788	acetyl-CoA synthetase; Provisional; Region: PRK00174
497978009789	Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966
497978009790	active site
497978009791	CoA binding site [chemical binding]; other site
497978009792	acyl-activating enzyme (AAE) consensus motif; other site
497978009793	AMP binding site [chemical binding]; other site
497978009794	acetate binding site [chemical binding]; other site
497978009795	Protein of unknown function (DUF805); Region: DUF805; pfam05656
497978009796	Fucose 4-O-acetylase and related acetyltransferases [Carbohydrate transport and metabolism]; Region: NolL; COG3594
497978009797	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
497978009798	Mechanosensitive ion channel; Region: MS_channel; pfam00924
497978009799	RNA methyltransferase, RsmE family; Region: TIGR00046
497978009800	16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713
497978009801	3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749
497978009802	3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413
497978009803	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
497978009804	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
497978009805	Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933
497978009806	FMN binding site [chemical binding]; other site
497978009807	active site
497978009808	substrate binding site [chemical binding]; other site
497978009809	catalytic residue [active]
497978009810	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
497978009811	putative DNA binding site [nucleotide binding]; other site
497978009812	dimerization interface [polypeptide binding]; other site
497978009813	putative Zn2+ binding site [ion binding]; other site
497978009814	peptide chain release factor 2; Provisional; Region: PRK08787
497978009815	This domain is found in peptide chain release factors; Region: PCRF; smart00937
497978009816	RF-1 domain; Region: RF-1; pfam00472
497978009817	ssDNA exonuclease RecJ; Provisional; Region: PRK11070
497978009818	DHH family; Region: DHH; pfam01368
497978009819	DHHA1 domain; Region: DHHA1; pfam02272
497978009820	pyridoxamine-phosphate oxidase; Region: pdxH; TIGR00558
497978009821	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243
497978009822	Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590
497978009823	phosphoglucosamine mutase; Provisional; Region: glmM; PRK10887
497978009824	GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802
497978009825	active site
497978009826	substrate binding site [chemical binding]; other site
497978009827	metal binding site [ion binding]; metal-binding site
497978009828	inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567
497978009829	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
497978009830	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein.  IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601
497978009831	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
497978009832	active site
497978009833	Predicted Fe-S-cluster oxidoreductase [General function prediction only]; Region: COG0727
497978009834	Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426
497978009835	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
497978009836	ferrichrome outer membrane transporter; Provisional; Region: PRK10044
497978009837	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
497978009838	N-terminal plug; other site
497978009839	ligand-binding site [chemical binding]; other site
497978009840	Predicted membrane protein [Function unknown]; Region: COG2119
497978009841	Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169
497978009842	Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169
497978009843	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
497978009844	pyruvate dehydrogenase dihydrolipoyltransacetylase; Validated; Region: aceF; PRK11854
497978009845	E3 interaction surface; other site
497978009846	lipoyl attachment site [posttranslational modification]; other site
497978009847	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
497978009848	E3 interaction surface; other site
497978009849	lipoyl attachment site [posttranslational modification]; other site
497978009850	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
497978009851	E3 interaction surface; other site
497978009852	lipoyl attachment site [posttranslational modification]; other site
497978009853	e3 binding domain; Region: E3_binding; pfam02817
497978009854	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
497978009855	pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405
497978009856	Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017
497978009857	dimer interface [polypeptide binding]; other site
497978009858	TPP-binding site [chemical binding]; other site
497978009859	Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410
497978009860	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
497978009861	Peptidase family M23; Region: Peptidase_M23; pfam01551
497978009862	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186
497978009863	UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331
497978009864	cell division protein FtsZ; Validated; Region: PRK09330
497978009865	FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes.  FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201
497978009866	nucleotide binding site [chemical binding]; other site
497978009867	SulA interaction site; other site
497978009868	Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849
497978009869	Cell division protein FtsA; Region: FtsA; smart00842
497978009870	Cell division protein FtsA; Region: FtsA; pfam14450
497978009871	POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478
497978009872	Cell division protein FtsQ; Region: FtsQ; pfam03799
497978009873	D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372
497978009874	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
497978009875	ATP-grasp domain; Region: ATP-grasp_4; cl17255
497978009876	UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421
497978009877	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
497978009878	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
497978009879	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
497978009880	undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726
497978009881	MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785
497978009882	active site
497978009883	homodimer interface [polypeptide binding]; other site
497978009884	glutathione synthetase; Provisional; Region: PRK05246
497978009885	Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951
497978009886	Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955
497978009887	Domain of unknown function (DUF1737); Region: DUF1737; pfam08410
497978009888	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
497978009889	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
497978009890	N-terminal plug; other site
497978009891	ligand-binding site [chemical binding]; other site
497978009892	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
497978009893	active site
497978009894	Neisseria meningitides Nape-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Nape_like_AP-endo; cd10281
497978009895	putative active site [active]
497978009896	putative catalytic site [active]
497978009897	putative DNA binding site [nucleotide binding]; other site
497978009898	putative phosphate binding site [ion binding]; other site
497978009899	metal binding site A [ion binding]; metal-binding site
497978009900	putative AP binding site [nucleotide binding]; other site
497978009901	putative metal binding site B [ion binding]; other site
497978009902	Arsenate Reductase (ArsC) family, Yffb subfamily; Yffb is an uncharacterized bacterial protein encoded by the yffb gene, related to the thioredoxin-fold arsenic reductases, ArsC. The structure of Yffb and the conservation of the catalytic cysteine...; Region: ArsC_Yffb; cd03035
497978009903	ArsC family; Region: ArsC; pfam03960
497978009904	putative catalytic residues [active]
497978009905	Uncharacterized protein conserved in bacteria (DUF2147); Region: DUF2147; pfam09917
497978009906	Protein of unknown function (DUF2424); Region: DUF2424; pfam10340
497978009907	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
497978009908	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
497978009909	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
497978009910	metal binding site [ion binding]; metal-binding site
497978009911	active site
497978009912	I-site; other site
497978009913	thiol:disulfide interchange protein precursor; Provisional; Region: dipZ; PRK00293
497978009914	Disulphide bond corrector protein DsbC; Region: DsbC; pfam11412
497978009915	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788
497978009916	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
497978009917	Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; pfam13557
497978009918	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
497978009919	Ankyrin repeats (many copies); Region: Ank_5; pfam13857
497978009920	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cl00250
497978009921	30S subunit binding site; other site
497978009922	putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212
497978009923	Catalytic domain of bacterial PuuE allantoinases, Schizosaccharomyces pombe chitin deacetylase 1 (SpCDA1), and similar proteins; Region: CE4_PuuE_SpCDA1; cd10977
497978009924	active site
497978009925	catalytic site [active]
497978009926	tetramer interface [polypeptide binding]; other site
497978009927	putative OHCU decarboxylase; Provisional; Region: PRK13798
497978009928	HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822
497978009929	active site
497978009930	homotetramer interface [polypeptide binding]; other site
497978009931	xanthine permease; Region: pbuX; TIGR03173
497978009932	Nucleoside-specific channel-forming protein, Tsx; Region: Channel_Tsx; cl04114
497978009933	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
497978009934	FAD binding domain; Region: FAD_binding_3; pfam01494
497978009935	allantoicase; Provisional; Region: PRK13257
497978009936	Allantoicase repeat; Region: Allantoicase; pfam03561
497978009937	Allantoicase repeat; Region: Allantoicase; pfam03561
497978009938	ureidoglycolate hydrolase; Provisional; Region: PRK03606
497978009939	Ureidoglycolate hydrolase [Nucleotide transport and metabolism]; Region: DAL3; COG3194
497978009940	3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830
497978009941	classical (c) SDRs; Region: SDR_c; cd05233
497978009942	NAD(P) binding site [chemical binding]; other site
497978009943	active site
497978009944	DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559
497978009945	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
497978009946	ATP binding site [chemical binding]; other site
497978009947	Mg2+ binding site [ion binding]; other site
497978009948	G-X-G motif; other site
497978009949	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
497978009950	anchoring element; other site
497978009951	dimer interface [polypeptide binding]; other site
497978009952	ATP binding site [chemical binding]; other site
497978009953	Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718
497978009954	active site
497978009955	metal binding site [ion binding]; metal-binding site
497978009956	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
497978009957	Uncharacterized protein family (UPF0227); Region: UPF0227; cl14886
497978009958	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
497978009959	PGAP1-like protein; Region: PGAP1; pfam07819
497978009960	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
497978009961	Uncharacterized protein conserved in bacteria [Function unknown]; Region: VgrG; COG3501
497978009962	Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954
497978009963	Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717
497978009964	Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296
497978009965	Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; pfam10106
497978009966	Disulfide bond formation protein DsbB; Region: DsbB; pfam02600
497978009967	Glutamate-cysteine ligase; Region: Glu_cys_ligase; cl17352
497978009968	Bacterial protein of unknown function (DUF924); Region: DUF924; pfam06041
497978009969	Protein of unknown function (DUF445); Region: DUF445; pfam04286
497978009970	methionine aminotransferase; Validated; Region: PRK09082
497978009971	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
497978009972	pyridoxal 5'-phosphate binding site [chemical binding]; other site
497978009973	homodimer interface [polypeptide binding]; other site
497978009974	catalytic residue [active]
497978009975	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
497978009976	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138
497978009977	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
497978009978	short chain dehydrogenase; Provisional; Region: PRK07832
497978009979	NAD(P) binding site [chemical binding]; other site
497978009980	active site
497978009981	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
497978009982	phosphate regulon transcriptional regulatory protein PhoB; Region: PhoB; TIGR02154
497978009983	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
497978009984	active site
497978009985	phosphorylation site [posttranslational modification]
497978009986	intermolecular recognition site; other site
497978009987	dimerization interface [polypeptide binding]; other site
497978009988	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
497978009989	DNA binding site [nucleotide binding]
497978009990	Domain of unknown function (DUF3329); Region: DUF3329; pfam11808
497978009991	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
497978009992	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
497978009993	putative active site [active]
497978009994	heme pocket [chemical binding]; other site
497978009995	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
497978009996	dimer interface [polypeptide binding]; other site
497978009997	phosphorylation site [posttranslational modification]
497978009998	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
497978009999	ATP binding site [chemical binding]; other site
497978010000	Mg2+ binding site [ion binding]; other site
497978010001	G-X-G motif; other site
497978010002	Secretory lipase; Region: LIP; pfam03583
497978010003	alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561
497978010004	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
497978010005	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
497978010006	Predicted acetamidase/formamidase [Energy production and conversion]; Region: COG2421
497978010007	phosphatidylserine decarboxylase; Reviewed; Region: psd; PRK00044
497978010008	Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897
497978010009	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
497978010010	active site residue [active]
497978010011	Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449
497978010012	active site residue [active]
497978010013	nicotinate phosphoribosyltransferase; Region: NAPRTase; TIGR01514
497978010014	Nicotinate phosphoribosyltransferase (NAPRTase), related to PncB. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting; Region: PncB_like; cd01401
497978010015	active site
497978010016	D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563
497978010017	putative active site [active]
497978010018	dimerization interface [polypeptide binding]; other site
497978010019	putative tRNAtyr binding site [nucleotide binding]; other site
497978010020	CT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_1; cd04870
497978010021	ACT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_2; cd04871
497978010022	phosphoserine phosphatase SerB; Region: serB; TIGR00338
497978010023	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
497978010024	motif II; other site
497978010025	Domain of unknown function (DUF4175); Region: DUF4175; pfam13779
497978010026	bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II-like protein; Provisional; Region: PRK14019
497978010027	3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926
497978010028	GTP cyclohydrolase II; Region: GTP_cyclohydro2; pfam00925
497978010029	dimerization interface [polypeptide binding]; other site
497978010030	active site
497978010031	lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209
497978010032	homopentamer interface [polypeptide binding]; other site
497978010033	active site
497978010034	transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202
497978010035	thiamine monophosphate kinase; Provisional; Region: PRK05731
497978010036	ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194
497978010037	ATP binding site [chemical binding]; other site
497978010038	dimerization interface [polypeptide binding]; other site
497978010039	Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971
497978010040	tetramer interfaces [polypeptide binding]; other site
497978010041	binuclear metal-binding site [ion binding]; other site
497978010042	N-acetylglucosamine-1-phosphate uridyltransferase (contains nucleotidyltransferase and I-patch acetyltransferase domains) [Cell envelope biogenesis, outer membrane]; Region: GlmU; COG1207
497978010043	N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540
497978010044	Substrate binding site; other site
497978010045	Mg++ binding site; other site
497978010046	N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353
497978010047	active site
497978010048	substrate binding site [chemical binding]; other site
497978010049	CoA binding site [chemical binding]; other site
497978010050	glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331
497978010051	Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans).  The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714
497978010052	glutaminase active site [active]
497978010053	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
497978010054	dimer interface [polypeptide binding]; other site
497978010055	active site
497978010056	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
497978010057	dimer interface [polypeptide binding]; other site
497978010058	active site
497978010059	glutamate racemase; Provisional; Region: PRK00865
497978010060	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
497978010061	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
497978010062	motif II; other site
497978010063	Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960
497978010064	agmatinase; Region: agmatinase; TIGR01230
497978010065	Formimidoylglutamase or HutE; Region: Formimidoylglutamase; cd09988
497978010066	putative active site [active]
497978010067	putative metal binding site [ion binding]; other site
497978010068	imidazolonepropionase; Validated; Region: PRK09356
497978010069	Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296
497978010070	active site
497978010071	putative proline-specific permease; Provisional; Region: proY; PRK10580
497978010072	Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332
497978010073	active sites [active]
497978010074	tetramer interface [polypeptide binding]; other site
497978010075	urocanate hydratase; Provisional; Region: PRK05414
497978010076	HutD; Region: HutD; pfam05962
497978010077	histidine utilization repressor, proteobacterial; Region: his_ut_repres; TIGR02018
497978010078	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
497978010079	DNA-binding site [nucleotide binding]; DNA binding site
497978010080	UTRA domain; Region: UTRA; pfam07702
497978010081	Acyltransferase family; Region: Acyl_transf_3; pfam01757
497978010082	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
497978010083	CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492
497978010084	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833
497978010085	Peptidase M15; Region: Peptidase_M15_3; cl01194
497978010086	aromatic amino acid transporter; Provisional; Region: PRK10238
497978010087	fumarylacetoacetase; Region: PLN02856
497978010088	Domain of unknown function (DUF1969); Region: DUF1969; pfam09298
497978010089	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
497978010090	GST_N family, Class Zeta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Zeta; cd03042
497978010091	maleylacetoacetate isomerase; Region: maiA; TIGR01262
497978010092	C-terminal domain interface [polypeptide binding]; other site
497978010093	GSH binding site (G-site) [chemical binding]; other site
497978010094	putative dimer interface [polypeptide binding]; other site
497978010095	C-terminal, alpha helical domain of Class Zeta Glutathione S-transferases; Region: GST_C_Zeta; cd03191
497978010096	dimer interface [polypeptide binding]; other site
497978010097	N-terminal domain interface [polypeptide binding]; other site
497978010098	maleylacetoacetate (MAA) substrate binding site (H site) [chemical binding]; other site
497978010099	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
497978010100	N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346
497978010101	Zn binding site [ion binding]; other site
497978010102	IclR helix-turn-helix domain; Region: HTH_IclR; cl17605
497978010103	Transcriptional regulator [Transcription]; Region: IclR; COG1414
497978010104	Bacterial transcriptional regulator; Region: IclR; pfam01614
497978010105	4-hydroxyphenylpyruvate dioxygenase and related hemolysins [Amino acid transport and metabolism / General function prediction only]; Region: COG3185
497978010106	N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342
497978010107	dimer interface [polypeptide binding]; other site
497978010108	C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250
497978010109	active site
497978010110	Fe binding site [ion binding]; other site
497978010111	Uncharacterized conserved protein [Function unknown]; Region: COG1683
497978010112	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131
497978010113	putative efflux protein, MATE family; Region: matE; TIGR00797
497978010114	cation binding site [ion binding]; other site
497978010115	Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385
497978010116	Sodium Bile acid symporter family; Region: SBF; pfam01758
497978010117	Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011
497978010118	Isochorismatase family; Region: Isochorismatase; pfam00857
497978010119	catalytic triad [active]
497978010120	metal binding site [ion binding]; metal-binding site
497978010121	conserved cis-peptide bond; other site
497978010122	Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
497978010123	dihydrodipicolinate synthase; Region: dapA; TIGR00674
497978010124	dimer interface [polypeptide binding]; other site
497978010125	active site
497978010126	catalytic residue [active]
497978010127	phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362
497978010128	bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415
497978010129	ATP binding site [chemical binding]; other site
497978010130	active site
497978010131	substrate binding site [chemical binding]; other site
497978010132	Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226
497978010133	recombination factor protein RarA; Reviewed; Region: PRK13342
497978010134	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
497978010135	Walker A motif; other site
497978010136	ATP binding site [chemical binding]; other site
497978010137	Walker B motif; other site
497978010138	arginine finger; other site
497978010139	MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002
497978010140	dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606
497978010141	Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995
497978010142	hypothetical protein; Provisional; Region: PRK05170
497978010143	Small integral membrane protein [Function unknown]; Region: COG5487; cl17674
497978010144	Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412
497978010145	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
497978010146	Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537
497978010147	nucleotide binding site/active site [active]
497978010148	HIT family signature motif; other site
497978010149	catalytic residue [active]
497978010150	A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194
497978010151	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
497978010152	minor groove reading motif; other site
497978010153	helix-hairpin-helix signature motif; other site
497978010154	substrate binding pocket [chemical binding]; other site
497978010155	active site
497978010156	iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525
497978010157	DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread  A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431
497978010158	DNA binding and oxoG recognition site [nucleotide binding]
497978010159	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
497978010160	Peptidase family M23; Region: Peptidase_M23; pfam01551
497978010161	Methyladenine glycosylase; Region: Adenine_glyco; pfam03352
497978010162	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
497978010163	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283
497978010164	putative NAD(P) binding site [chemical binding]; other site
497978010165	putative substrate binding site [chemical binding]; other site
497978010166	catalytic Zn binding site [ion binding]; other site
497978010167	structural Zn binding site [ion binding]; other site
497978010168	dimer interface [polypeptide binding]; other site
497978010169	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
497978010170	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
497978010171	DNA-binding site [nucleotide binding]; DNA binding site
497978010172	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
497978010173	pyridoxal 5'-phosphate binding site [chemical binding]; other site
497978010174	homodimer interface [polypeptide binding]; other site
497978010175	catalytic residue [active]
497978010176	Transcriptional regulator [Transcription]; Region: LysR; COG0583
497978010177	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
497978010178	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA; cd08478
497978010179	putative effector binding pocket; other site
497978010180	dimerization interface [polypeptide binding]; other site
497978010181	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
497978010182	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
497978010183	active site
497978010184	catalytic tetrad [active]
497978010185	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
497978010186	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
497978010187	putative substrate translocation pore; other site
497978010188	Uncharacterized subgroup of the steroidogenic acute regulatory protein (StAR)-related lipid transfer (START) domain family; Region: START_1; cd08876
497978010189	putative lipid binding site [chemical binding]; other site
497978010190	dihydrodipicolinate reductase; Provisional; Region: PRK00048
497978010191	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
497978010192	Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173
497978010193	chaperone protein DnaJ; Provisional; Region: PRK10767
497978010194	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
497978010195	HSP70 interaction site [polypeptide binding]; other site
497978010196	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262
497978010197	substrate binding site [polypeptide binding]; other site
497978010198	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
497978010199	Zn binding sites [ion binding]; other site
497978010200	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
497978010201	dimer interface [polypeptide binding]; other site
497978010202	Inorganic H+ pyrophosphatase; Region: H_PPase; pfam03030
497978010203	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
497978010204	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
497978010205	HlyD family secretion protein; Region: HlyD_3; pfam13437
497978010206	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
497978010207	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
497978010208	AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246
497978010209	phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009
497978010210	Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352
497978010211	pyrimidine utilization transport protein G; Region: RutG; TIGR03616
497978010212	Transcriptional regulator [Transcription]; Region: LysR; COG0583
497978010213	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
497978010214	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
497978010215	dimerization interface [polypeptide binding]; other site
497978010216	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
497978010217	dihydroxy-acid dehydratase; Provisional; Region: PRK12448
497978010218	methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005
497978010219	Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646
497978010220	putative active site [active]
497978010221	substrate binding site [chemical binding]; other site
497978010222	putative cosubstrate binding site; other site
497978010223	catalytic site [active]
497978010224	C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704
497978010225	substrate binding site [chemical binding]; other site
497978010226	16S rRNA methyltransferase B; Provisional; Region: PRK10901
497978010227	NusB family; Region: NusB; pfam01029
497978010228	putative RNA binding site [nucleotide binding]; other site
497978010229	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
497978010230	S-adenosylmethionine binding site [chemical binding]; other site
497978010231	uncharacterized bacterial and archaeal solute carrier 6 subfamily; solute-binding domain; Region: SLC6sbd_u1; cd10334
497978010232	Na2 binding site [ion binding]; other site
497978010233	putative substrate binding site 1 [chemical binding]; other site
497978010234	Na binding site 1 [ion binding]; other site
497978010235	putative substrate binding site 2 [chemical binding]; other site
497978010236	outer membrane protein; Region: OMP_w_GlyGly; TIGR04219
497978010237	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
497978010238	GST_N family, unknown subfamily 4; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_4; cd03056
497978010239	putative C-terminal domain interface [polypeptide binding]; other site
497978010240	putative GSH binding site (G-site) [chemical binding]; other site
497978010241	putative dimer interface [polypeptide binding]; other site
497978010242	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776
497978010243	dimer interface [polypeptide binding]; other site
497978010244	N-terminal domain interface [polypeptide binding]; other site
497978010245	substrate binding pocket (H-site) [chemical binding]; other site
497978010246	tyrosyl-tRNA synthetase; Validated; Region: PRK05912
497978010247	catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805
497978010248	active site
497978010249	HIGH motif; other site
497978010250	dimer interface [polypeptide binding]; other site
497978010251	KMSKS motif; other site
497978010252	anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585
497978010253	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
497978010254	iron-sulfur cluster insertion protein ErpA; Provisional; Region: PRK13623
497978010255	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
497978010256	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
497978010257	putative ABC transporter ATP-binding protein; Provisional; Region: PRK10636
497978010258	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
497978010259	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
497978010260	ABC transporter; Region: ABC_tran_2; pfam12848
497978010261	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
497978010262	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
497978010263	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
497978010264	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316
497978010265	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
497978010266	Integrase core domain; Region: rve; pfam00665
497978010267	Aminoglycoside 3'-phosphotransferase (APH). The APH subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin...; Region: APH; cd05150
497978010268	Phosphotransferase enzyme family; Region: APH; pfam01636
497978010269	active site
497978010270	ATP binding site [chemical binding]; other site
497978010271	antibiotic binding site [chemical binding]; other site
497978010272	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316
497978010273	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
497978010274	Integrase core domain; Region: rve; pfam00665
497978010275	Initiator Replication protein; Region: Rep_3; pfam01051
497978010276	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2739; cl17893
497978010277	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
497978010278	IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717
497978010279	Modifier of rudimentary (Mod(r)) protein; Region: Mod_r; pfam07200
497978010280	Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007
497978010281	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
497978010282	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005
497978010283	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
497978010284	IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817
497978010285	Macrolide 2'-Phosphotransferase (MPH2'). MPH2' is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase; Region: MPH2' cd05152
497978010286	putative active site [active]
497978010287	putative substrate binding site [chemical binding]; other site
497978010288	Phosphotransferase enzyme family; Region: APH; pfam01636
497978010289	ATP binding site [chemical binding]; other site
497978010290	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
497978010291	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
497978010292	ABC transporter; Region: ABC_tran_2; pfam12848
497978010293	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
497978010294	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
497978010295	Ribosomal RNA methyltransferase (FmrO); Region: FmrO; pfam07091
497978010296	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
497978010297	Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737
497978010298	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
497978010299	Transposase zinc-binding domain; Region: Zn_Tnp_IS91; pfam14319
497978010300	Ribosomal protein S27; Region: Ribosomal_S27e; cl00897
497978010301	Putative transposase; Region: Y2_Tnp; pfam04986
497978010302	DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
497978010303	dihydropteroate synthase; Region: DHPS; TIGR01496
497978010304	substrate binding pocket [chemical binding]; other site
497978010305	dimer interface [polypeptide binding]; other site
497978010306	inhibitor binding site; inhibition site
497978010307	Small Multidrug Resistance protein; Region: Multi_Drug_Res; pfam00893
497978010308	aminoglycoside resistance protein; Provisional; Region: PRK13746
497978010309	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
497978010310	active site
497978010311	NTP binding site [chemical binding]; other site
497978010312	metal binding triad [ion binding]; metal-binding site
497978010313	antibiotic binding site [chemical binding]; other site
497978010314	Domain of unknown function (DUF4111); Region: DUF4111; pfam13427
497978010315	Ribosomal protein L37e; Region: Ribosomal_L37e; cl00932
497978010316	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
497978010317	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
497978010318	Coenzyme A binding pocket [chemical binding]; other site
497978010319	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
497978010320	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
497978010321	Coenzyme A binding pocket [chemical binding]; other site