-- dump date 20140618_190805 -- class Genbank::misc_feature -- table misc_feature_note -- id note 1100841000001 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 1100841000002 EamA-like transporter family; Region: EamA; pfam00892 1100841000003 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 1100841000004 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1100841000005 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1100841000006 dimerization interface [polypeptide binding]; other site 1100841000007 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1100841000008 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1100841000009 putative substrate translocation pore; other site 1100841000010 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1100841000011 Uncharacterized conserved protein [Function unknown]; Region: COG3791 1100841000012 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1100841000013 S-adenosylmethionine binding site [chemical binding]; other site 1100841000014 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1100841000015 Predicted NAD/FAD-binding protein [General function prediction only]; Region: COG2907 1100841000016 Pirin-related protein [General function prediction only]; Region: COG1741 1100841000017 Pirin; Region: Pirin; pfam02678 1100841000018 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 1100841000019 Isochorismatase family; Region: Isochorismatase; pfam00857 1100841000020 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 1100841000021 catalytic triad [active] 1100841000022 dimer interface [polypeptide binding]; other site 1100841000023 conserved cis-peptide bond; other site 1100841000024 LysR family transcriptional regulator; Provisional; Region: PRK14997 1100841000025 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1100841000026 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1100841000027 dimerization interface [polypeptide binding]; other site 1100841000028 succinic semialdehyde dehydrogenase; Region: PLN02278 1100841000029 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 1100841000030 tetramerization interface [polypeptide binding]; other site 1100841000031 NAD(P) binding site [chemical binding]; other site 1100841000032 catalytic residues [active] 1100841000033 4-aminobutyrate aminotransferase; Provisional; Region: PRK06777 1100841000034 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1100841000035 inhibitor-cofactor binding pocket; inhibition site 1100841000036 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1100841000037 catalytic residue [active] 1100841000038 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1100841000039 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1100841000040 DNA-binding site [nucleotide binding]; DNA binding site 1100841000041 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1100841000042 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1100841000043 homodimer interface [polypeptide binding]; other site 1100841000044 catalytic residue [active] 1100841000045 gamma-aminobutyrate permease; Region: GABAperm; TIGR01773 1100841000046 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1100841000047 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1100841000048 non-specific DNA binding site [nucleotide binding]; other site 1100841000049 salt bridge; other site 1100841000050 sequence-specific DNA binding site [nucleotide binding]; other site 1100841000051 Cupin domain; Region: Cupin_2; pfam07883 1100841000052 AzlC protein; Region: AzlC; cl00570 1100841000053 Branched-chain amino acid transport protein (AzlD); Region: AzlD; pfam05437 1100841000054 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 1100841000055 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1100841000056 dimer interface [polypeptide binding]; other site 1100841000057 ssDNA binding site [nucleotide binding]; other site 1100841000058 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1100841000059 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1100841000060 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1100841000061 putative substrate translocation pore; other site 1100841000062 hypothetical protein; Provisional; Region: PRK14013 1100841000063 Putative transcription activator [Transcription]; Region: TenA; COG0819 1100841000064 GlpM protein; Region: GlpM; pfam06942 1100841000065 Protein of unknown function (DUF1304); Region: DUF1304; pfam06993 1100841000066 2-enoyl thioester reductase (ETR) like proteins, child 2; Region: ETR_like_2; cd08292 1100841000067 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1100841000068 putative NAD(P) binding site [chemical binding]; other site 1100841000069 putative dimer interface [polypeptide binding]; other site 1100841000070 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1100841000071 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1100841000072 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 1100841000073 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1100841000074 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1100841000075 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 1100841000076 AAA domain; Region: AAA_14; pfam13173 1100841000077 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1100841000078 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1100841000079 metal binding site [ion binding]; metal-binding site 1100841000080 active site 1100841000081 I-site; other site 1100841000082 BCCT family transporter; Region: BCCT; pfam02028 1100841000083 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 1100841000084 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 1100841000085 Na binding site [ion binding]; other site 1100841000086 Protein of unknown function, DUF485; Region: DUF485; pfam04341 1100841000087 Na+/proline symporter [Amino acid transport and metabolism / General function prediction only]; Region: PutP; COG0591 1100841000088 Na binding site [ion binding]; other site 1100841000089 PAS fold; Region: PAS_7; pfam12860 1100841000090 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 1100841000091 putative active site [active] 1100841000092 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1100841000093 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1100841000094 dimer interface [polypeptide binding]; other site 1100841000095 phosphorylation site [posttranslational modification] 1100841000096 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1100841000097 ATP binding site [chemical binding]; other site 1100841000098 Mg2+ binding site [ion binding]; other site 1100841000099 G-X-G motif; other site 1100841000100 Response regulator receiver domain; Region: Response_reg; pfam00072 1100841000101 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1100841000102 active site 1100841000103 phosphorylation site [posttranslational modification] 1100841000104 intermolecular recognition site; other site 1100841000105 dimerization interface [polypeptide binding]; other site 1100841000106 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1100841000107 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1100841000108 active site 1100841000109 phosphorylation site [posttranslational modification] 1100841000110 intermolecular recognition site; other site 1100841000111 dimerization interface [polypeptide binding]; other site 1100841000112 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1100841000113 DNA binding residues [nucleotide binding] 1100841000114 dimerization interface [polypeptide binding]; other site 1100841000115 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1100841000116 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 1100841000117 dimethyl sulfone monooxygenase SfnG; Region: LLM_DMSO2_sfnG; TIGR04021 1100841000118 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 1100841000119 active site 1100841000120 dimer interface [polypeptide binding]; other site 1100841000121 non-prolyl cis peptide bond; other site 1100841000122 insertion regions; other site 1100841000123 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 1100841000124 MULE transposase domain; Region: MULE; pfam10551 1100841000125 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 1100841000126 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 1100841000127 dimerization interface [polypeptide binding]; other site 1100841000128 putative DNA binding site [nucleotide binding]; other site 1100841000129 putative Zn2+ binding site [ion binding]; other site 1100841000130 AsnC family; Region: AsnC_trans_reg; pfam01037 1100841000131 Isochorismatase family; Region: Isochorismatase; pfam00857 1100841000132 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 1100841000133 catalytic triad [active] 1100841000134 conserved cis-peptide bond; other site 1100841000135 acetyl-CoA synthetase; Provisional; Region: PRK00174 1100841000136 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 1100841000137 active site 1100841000138 CoA binding site [chemical binding]; other site 1100841000139 acyl-activating enzyme (AAE) consensus motif; other site 1100841000140 AMP binding site [chemical binding]; other site 1100841000141 acetate binding site [chemical binding]; other site 1100841000142 Protein of unknown function (DUF805); Region: DUF805; pfam05656 1100841000143 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1100841000144 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1100841000145 RNA methyltransferase, RsmE family; Region: TIGR00046 1100841000146 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 1100841000147 3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749 1100841000148 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 1100841000149 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1100841000150 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1100841000151 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 1100841000152 FMN binding site [chemical binding]; other site 1100841000153 active site 1100841000154 substrate binding site [chemical binding]; other site 1100841000155 catalytic residue [active] 1100841000156 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1100841000157 putative DNA binding site [nucleotide binding]; other site 1100841000158 dimerization interface [polypeptide binding]; other site 1100841000159 putative Zn2+ binding site [ion binding]; other site 1100841000160 peptide chain release factor 2; Provisional; Region: PRK08787 1100841000161 This domain is found in peptide chain release factors; Region: PCRF; smart00937 1100841000162 RF-1 domain; Region: RF-1; pfam00472 1100841000163 ssDNA exonuclease RecJ; Provisional; Region: PRK11070 1100841000164 DHH family; Region: DHH; pfam01368 1100841000165 DHHA1 domain; Region: DHHA1; pfam02272 1100841000166 pyridoxamine-phosphate oxidase; Region: pdxH; TIGR00558 1100841000167 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 1100841000168 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 1100841000169 phosphoglucosamine mutase; Provisional; Region: glmM; PRK10887 1100841000170 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 1100841000171 active site 1100841000172 substrate binding site [chemical binding]; other site 1100841000173 metal binding site [ion binding]; metal-binding site 1100841000174 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 1100841000175 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1100841000176 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 1100841000177 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 1100841000178 active site 1100841000179 Predicted Fe-S-cluster oxidoreductase [General function prediction only]; Region: COG0727 1100841000180 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 1100841000181 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1100841000182 ferrichrome outer membrane transporter; Provisional; Region: PRK10044 1100841000183 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1100841000184 N-terminal plug; other site 1100841000185 ligand-binding site [chemical binding]; other site 1100841000186 Predicted membrane protein [Function unknown]; Region: COG2119 1100841000187 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 1100841000188 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 1100841000189 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1100841000190 pyruvate dehydrogenase dihydrolipoyltransacetylase; Validated; Region: aceF; PRK11854 1100841000191 E3 interaction surface; other site 1100841000192 lipoyl attachment site [posttranslational modification]; other site 1100841000193 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1100841000194 E3 interaction surface; other site 1100841000195 lipoyl attachment site [posttranslational modification]; other site 1100841000196 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1100841000197 E3 interaction surface; other site 1100841000198 lipoyl attachment site [posttranslational modification]; other site 1100841000199 e3 binding domain; Region: E3_binding; pfam02817 1100841000200 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1100841000201 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 1100841000202 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 1100841000203 dimer interface [polypeptide binding]; other site 1100841000204 TPP-binding site [chemical binding]; other site 1100841000205 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 1100841000206 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1100841000207 Peptidase family M23; Region: Peptidase_M23; pfam01551 1100841000208 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186 1100841000209 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 1100841000210 cell division protein FtsZ; Validated; Region: PRK09330 1100841000211 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 1100841000212 nucleotide binding site [chemical binding]; other site 1100841000213 SulA interaction site; other site 1100841000214 Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849 1100841000215 Cell division protein FtsA; Region: FtsA; smart00842 1100841000216 Cell division protein FtsA; Region: FtsA; pfam14450 1100841000217 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 1100841000218 Cell division protein FtsQ; Region: FtsQ; pfam03799 1100841000219 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1100841000220 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 1100841000221 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1100841000222 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1100841000223 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1100841000224 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 1100841000225 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 1100841000226 active site 1100841000227 homodimer interface [polypeptide binding]; other site 1100841000228 glutathione synthetase; Provisional; Region: PRK05246 1100841000229 Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951 1100841000230 Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955 1100841000231 Domain of unknown function (DUF1737); Region: DUF1737; pfam08410 1100841000232 potential frameshift: common BLAST hit: gi|387122224|ref|YP_006288106.1| TonB-dependent siderophore receptor 1100841000233 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 1100841000234 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1100841000235 N-terminal plug; other site 1100841000236 ligand-binding site [chemical binding]; other site 1100841000237 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 1100841000238 Domain of unknown function (DUF4263); Region: DUF4263; pfam14082 1100841000239 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1100841000240 active site 1100841000241 Neisseria meningitides Nape-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Nape_like_AP-endo; cd10281 1100841000242 putative active site [active] 1100841000243 putative catalytic site [active] 1100841000244 putative DNA binding site [nucleotide binding]; other site 1100841000245 putative phosphate binding site [ion binding]; other site 1100841000246 metal binding site A [ion binding]; metal-binding site 1100841000247 putative AP binding site [nucleotide binding]; other site 1100841000248 putative metal binding site B [ion binding]; other site 1100841000249 Arsenate Reductase (ArsC) family, Yffb subfamily; Yffb is an uncharacterized bacterial protein encoded by the yffb gene, related to the thioredoxin-fold arsenic reductases, ArsC. The structure of Yffb and the conservation of the catalytic cysteine...; Region: ArsC_Yffb; cd03035 1100841000250 ArsC family; Region: ArsC; pfam03960 1100841000251 putative catalytic residues [active] 1100841000252 Uncharacterized protein conserved in bacteria (DUF2147); Region: DUF2147; pfam09917 1100841000253 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 1100841000254 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1100841000255 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1100841000256 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1100841000257 metal binding site [ion binding]; metal-binding site 1100841000258 active site 1100841000259 I-site; other site 1100841000260 thiol:disulfide interchange protein precursor; Provisional; Region: dipZ; PRK00293 1100841000261 Disulphide bond corrector protein DsbC; Region: DsbC; pfam11412 1100841000262 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 1100841000263 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1100841000264 Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; pfam13557 1100841000265 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1100841000266 Ankyrin repeats (many copies); Region: Ank_5; pfam13857 1100841000267 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cl00250 1100841000268 30S subunit binding site; other site 1100841000269 Catalytic domain of bacterial PuuE allantoinases, Schizosaccharomyces pombe chitin deacetylase 1 (SpCDA1), and similar proteins; Region: CE4_PuuE_SpCDA1; cd10977 1100841000270 tetramer interface [polypeptide binding]; other site 1100841000271 active site 1100841000272 HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822 1100841000273 active site 1100841000274 homotetramer interface [polypeptide binding]; other site 1100841000275 xanthine permease; Region: pbuX; TIGR03173 1100841000276 Nucleoside-specific channel-forming protein, Tsx; Region: Channel_Tsx; cl04114 1100841000277 hypothetical protein; Provisional; Region: PRK07236 1100841000278 FAD binding domain; Region: FAD_binding_3; pfam01494 1100841000279 allantoicase; Region: allantoicase; TIGR02961 1100841000280 Allantoicase repeat; Region: Allantoicase; pfam03561 1100841000281 Allantoicase repeat; Region: Allantoicase; pfam03561 1100841000282 ureidoglycolate hydrolase; Provisional; Region: PRK03606 1100841000283 Ureidoglycolate hydrolase [Nucleotide transport and metabolism]; Region: DAL3; COG3194 1100841000284 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 1100841000285 classical (c) SDRs; Region: SDR_c; cd05233 1100841000286 NAD(P) binding site [chemical binding]; other site 1100841000287 active site 1100841000288 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 1100841000289 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1100841000290 ATP binding site [chemical binding]; other site 1100841000291 Mg2+ binding site [ion binding]; other site 1100841000292 G-X-G motif; other site 1100841000293 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 1100841000294 anchoring element; other site 1100841000295 dimer interface [polypeptide binding]; other site 1100841000296 ATP binding site [chemical binding]; other site 1100841000297 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 1100841000298 active site 1100841000299 metal binding site [ion binding]; metal-binding site 1100841000300 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 1100841000301 Uncharacterized protein family (UPF0227); Region: UPF0227; cl14886 1100841000302 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1100841000303 PGAP1-like protein; Region: PGAP1; pfam07819 1100841000304 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1100841000305 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1100841000306 Bacterial SH3 domain; Region: SH3_4; pfam06347 1100841000307 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 1100841000308 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1100841000309 Peptidase M15; Region: Peptidase_M15_3; cl01194 1100841000310 potential frameshift: common BLAST hit: gi|215481875|ref|YP_002324057.1| Rhs element Vgr family protein 1100841000311 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 1100841000312 Uncharacterized protein conserved in bacteria [Function unknown]; Region: VgrG; COG3501 1100841000313 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 1100841000314 Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296 1100841000315 Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; pfam10106 1100841000316 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 1100841000317 Disulfide bond formation protein DsbB; Region: DsbB; pfam02600 1100841000318 Glutamate-cysteine ligase; Region: Glu_cys_ligase; cl17352 1100841000319 Bacterial protein of unknown function (DUF924); Region: DUF924; pfam06041 1100841000320 Protein of unknown function (DUF445); Region: DUF445; pfam04286 1100841000321 methionine aminotransferase; Validated; Region: PRK09082 1100841000322 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1100841000323 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1100841000324 homodimer interface [polypeptide binding]; other site 1100841000325 catalytic residue [active] 1100841000326 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 1100841000327 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138 1100841000328 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1100841000329 short chain dehydrogenase; Provisional; Region: PRK07832 1100841000330 NAD(P) binding site [chemical binding]; other site 1100841000331 active site 1100841000332 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1100841000333 phosphate regulon transcriptional regulatory protein PhoB; Region: PhoB; TIGR02154 1100841000334 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1100841000335 active site 1100841000336 phosphorylation site [posttranslational modification] 1100841000337 intermolecular recognition site; other site 1100841000338 dimerization interface [polypeptide binding]; other site 1100841000339 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1100841000340 DNA binding site [nucleotide binding] 1100841000341 Domain of unknown function (DUF3329); Region: DUF3329; pfam11808 1100841000342 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1100841000343 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1100841000344 putative active site [active] 1100841000345 heme pocket [chemical binding]; other site 1100841000346 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1100841000347 dimer interface [polypeptide binding]; other site 1100841000348 phosphorylation site [posttranslational modification] 1100841000349 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1100841000350 ATP binding site [chemical binding]; other site 1100841000351 Mg2+ binding site [ion binding]; other site 1100841000352 G-X-G motif; other site 1100841000353 Secretory lipase; Region: LIP; pfam03583 1100841000354 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 1100841000355 phosphatidylserine decarboxylase; Reviewed; Region: psd; PRK00044 1100841000356 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 1100841000357 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 1100841000358 active site residue [active] 1100841000359 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 1100841000360 active site residue [active] 1100841000361 nicotinate phosphoribosyltransferase; Region: NAPRTase; TIGR01514 1100841000362 Nicotinate phosphoribosyltransferase (NAPRTase), related to PncB. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting; Region: PncB_like; cd01401 1100841000363 active site 1100841000364 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 1100841000365 putative active site [active] 1100841000366 dimerization interface [polypeptide binding]; other site 1100841000367 putative tRNAtyr binding site [nucleotide binding]; other site 1100841000368 CT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_1; cd04870 1100841000369 ACT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_2; cd04871 1100841000370 phosphoserine phosphatase SerB; Region: serB; TIGR00338 1100841000371 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1100841000372 motif II; other site 1100841000373 Domain of unknown function (DUF4175); Region: DUF4175; pfam13779 1100841000374 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II-like protein; Provisional; Region: PRK14019 1100841000375 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 1100841000376 GTP cyclohydrolase II; Region: GTP_cyclohydro2; pfam00925 1100841000377 dimerization interface [polypeptide binding]; other site 1100841000378 active site 1100841000379 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 1100841000380 homopentamer interface [polypeptide binding]; other site 1100841000381 active site 1100841000382 transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202 1100841000383 thiamine monophosphate kinase; Provisional; Region: PRK05731 1100841000384 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 1100841000385 ATP binding site [chemical binding]; other site 1100841000386 dimerization interface [polypeptide binding]; other site 1100841000387 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 1100841000388 tetramer interfaces [polypeptide binding]; other site 1100841000389 binuclear metal-binding site [ion binding]; other site 1100841000390 N-acetylglucosamine-1-phosphate uridyltransferase (contains nucleotidyltransferase and I-patch acetyltransferase domains) [Cell envelope biogenesis, outer membrane]; Region: GlmU; COG1207 1100841000391 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 1100841000392 Substrate binding site; other site 1100841000393 Mg++ binding site; other site 1100841000394 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 1100841000395 active site 1100841000396 substrate binding site [chemical binding]; other site 1100841000397 CoA binding site [chemical binding]; other site 1100841000398 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 1100841000399 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 1100841000400 glutaminase active site [active] 1100841000401 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 1100841000402 dimer interface [polypeptide binding]; other site 1100841000403 active site 1100841000404 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 1100841000405 dimer interface [polypeptide binding]; other site 1100841000406 active site 1100841000407 glutamate racemase; Provisional; Region: PRK00865 1100841000408 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 1100841000409 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1100841000410 motif II; other site 1100841000411 Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960 1100841000412 agmatinase; Region: agmatinase; TIGR01230 1100841000413 Formimidoylglutamase or HutE; Region: Formimidoylglutamase; cd09988 1100841000414 putative active site [active] 1100841000415 putative metal binding site [ion binding]; other site 1100841000416 imidazolonepropionase; Validated; Region: PRK09356 1100841000417 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296 1100841000418 active site 1100841000419 putative proline-specific permease; Provisional; Region: proY; PRK10580 1100841000420 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 1100841000421 active sites [active] 1100841000422 tetramer interface [polypeptide binding]; other site 1100841000423 urocanate hydratase; Provisional; Region: PRK05414 1100841000424 HutD; Region: HutD; pfam05962 1100841000425 histidine utilization repressor, proteobacterial; Region: his_ut_repres; TIGR02018 1100841000426 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1100841000427 DNA-binding site [nucleotide binding]; DNA binding site 1100841000428 UTRA domain; Region: UTRA; pfam07702 1100841000429 Acyltransferase family; Region: Acyl_transf_3; pfam01757 1100841000430 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 1100841000431 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 1100841000432 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 1100841000433 Peptidase M15; Region: Peptidase_M15_3; cl01194 1100841000434 aromatic amino acid transporter; Provisional; Region: PRK10238 1100841000435 fumarylacetoacetase; Region: PLN02856 1100841000436 Domain of unknown function (DUF1969); Region: DUF1969; pfam09298 1100841000437 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 1100841000438 GST_N family, Class Zeta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Zeta; cd03042 1100841000439 maleylacetoacetate isomerase; Region: maiA; TIGR01262 1100841000440 C-terminal domain interface [polypeptide binding]; other site 1100841000441 GSH binding site (G-site) [chemical binding]; other site 1100841000442 putative dimer interface [polypeptide binding]; other site 1100841000443 C-terminal, alpha helical domain of Class Zeta Glutathione S-transferases; Region: GST_C_Zeta; cd03191 1100841000444 dimer interface [polypeptide binding]; other site 1100841000445 N-terminal domain interface [polypeptide binding]; other site 1100841000446 maleylacetoacetate (MAA) substrate binding site (H site) [chemical binding]; other site 1100841000447 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1100841000448 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 1100841000449 Zn binding site [ion binding]; other site 1100841000450 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 1100841000451 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1100841000452 Bacterial transcriptional regulator; Region: IclR; pfam01614 1100841000453 4-hydroxyphenylpyruvate dioxygenase and related hemolysins [Amino acid transport and metabolism / General function prediction only]; Region: COG3185 1100841000454 N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342 1100841000455 dimer interface [polypeptide binding]; other site 1100841000456 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250 1100841000457 active site 1100841000458 Fe binding site [ion binding]; other site 1100841000459 Uncharacterized conserved protein [Function unknown]; Region: COG1683 1100841000460 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 1100841000461 putative efflux protein, MATE family; Region: matE; TIGR00797 1100841000462 cation binding site [ion binding]; other site 1100841000463 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 1100841000464 Sodium Bile acid symporter family; Region: SBF; pfam01758 1100841000465 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 1100841000466 Isochorismatase family; Region: Isochorismatase; pfam00857 1100841000467 catalytic triad [active] 1100841000468 metal binding site [ion binding]; metal-binding site 1100841000469 conserved cis-peptide bond; other site 1100841000470 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 1100841000471 dihydrodipicolinate synthase; Region: dapA; TIGR00674 1100841000472 dimer interface [polypeptide binding]; other site 1100841000473 active site 1100841000474 catalytic residue [active] 1100841000475 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 1100841000476 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 1100841000477 ATP binding site [chemical binding]; other site 1100841000478 active site 1100841000479 substrate binding site [chemical binding]; other site 1100841000480 Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226 1100841000481 recombination factor protein RarA; Reviewed; Region: PRK13342 1100841000482 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1100841000483 Walker A motif; other site 1100841000484 ATP binding site [chemical binding]; other site 1100841000485 Walker B motif; other site 1100841000486 arginine finger; other site 1100841000487 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 1100841000488 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 1100841000489 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 1100841000490 hypothetical protein; Provisional; Region: PRK05170 1100841000491 Small integral membrane protein [Function unknown]; Region: COG5487; cl17674 1100841000492 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 1100841000493 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1100841000494 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 1100841000495 nucleotide binding site/active site [active] 1100841000496 HIT family signature motif; other site 1100841000497 catalytic residue [active] 1100841000498 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 1100841000499 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1100841000500 minor groove reading motif; other site 1100841000501 helix-hairpin-helix signature motif; other site 1100841000502 substrate binding pocket [chemical binding]; other site 1100841000503 active site 1100841000504 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 1100841000505 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 1100841000506 DNA binding and oxoG recognition site [nucleotide binding] 1100841000507 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1100841000508 Peptidase family M23; Region: Peptidase_M23; pfam01551 1100841000509 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 1100841000510 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 1100841000511 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 1100841000512 putative NAD(P) binding site [chemical binding]; other site 1100841000513 putative substrate binding site [chemical binding]; other site 1100841000514 catalytic Zn binding site [ion binding]; other site 1100841000515 structural Zn binding site [ion binding]; other site 1100841000516 dimer interface [polypeptide binding]; other site 1100841000517 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1100841000518 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1100841000519 DNA-binding site [nucleotide binding]; DNA binding site 1100841000520 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1100841000521 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1100841000522 homodimer interface [polypeptide binding]; other site 1100841000523 catalytic residue [active] 1100841000524 membrane-bound lytic murein transglycosylase D; Provisional; Region: mltD; PRK10783 1100841000525 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1100841000526 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1100841000527 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA; cd08478 1100841000528 putative effector binding pocket; other site 1100841000529 dimerization interface [polypeptide binding]; other site 1100841000530 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1100841000531 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1100841000532 active site 1100841000533 catalytic tetrad [active] 1100841000534 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1100841000535 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1100841000536 putative substrate translocation pore; other site 1100841000537 Uncharacterized subgroup of the steroidogenic acute regulatory protein (StAR)-related lipid transfer (START) domain family; Region: START_1; cd08876 1100841000538 putative lipid binding site [chemical binding]; other site 1100841000539 dihydrodipicolinate reductase; Provisional; Region: PRK00048 1100841000540 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 1100841000541 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 1100841000542 chaperone protein DnaJ; Provisional; Region: PRK10767 1100841000543 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1100841000544 HSP70 interaction site [polypeptide binding]; other site 1100841000545 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 1100841000546 substrate binding site [polypeptide binding]; other site 1100841000547 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 1100841000548 Zn binding sites [ion binding]; other site 1100841000549 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 1100841000550 dimer interface [polypeptide binding]; other site 1100841000551 Inorganic H+ pyrophosphatase; Region: H_PPase; pfam03030 1100841000552 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 1100841000553 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1100841000554 HlyD family secretion protein; Region: HlyD_3; pfam13437 1100841000555 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1100841000556 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1100841000557 AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246 1100841000558 phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009 1100841000559 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 1100841000560 pyrimidine utilization transport protein G; Region: RutG; TIGR03616 1100841000561 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1100841000562 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1100841000563 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1100841000564 dimerization interface [polypeptide binding]; other site 1100841000565 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1100841000566 potential protein location (dihydroxy-acid dehydratase [Acinetobacter baumannii TYTH-1]) that overlaps RNA (16S ribosomal RNA) 1100841000567 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 1100841000568 substrate binding site [chemical binding]; other site 1100841000569 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1100841000570 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1100841000571 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 1100841000572 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1100841000573 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1100841000574 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1100841000575 putative effector binding pocket; other site 1100841000576 dimerization interface [polypeptide binding]; other site 1100841000577 GrpE; Region: GrpE; pfam01025 1100841000578 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 1100841000579 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 1100841000580 dimer interface [polypeptide binding]; other site 1100841000581 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 1100841000582 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1100841000583 nucleotide binding site [chemical binding]; other site 1100841000584 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 1100841000585 active site 1100841000586 Dual-action HEIGH metallo-peptidase; Region: Peptidase_M57; pfam12388 1100841000587 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 1100841000588 active site 1100841000589 Transglycosylase SLT domain; Region: SLT_2; pfam13406 1100841000590 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1100841000591 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1100841000592 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1100841000593 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 1100841000594 ATP-grasp domain; Region: ATP-grasp; pfam02222 1100841000595 AIR carboxylase; Region: AIRC; pfam00731 1100841000596 Protein of unknown function, DUF486; Region: DUF486; cl01236 1100841000597 UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase; Region: mpl; TIGR01081 1100841000598 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1100841000599 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1100841000600 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1100841000601 Bacterial low temperature requirement A protein (LtrA); Region: LtrA; cl01754 1100841000602 PAP2_like proteins, BcrC_like subfamily. Several members of this family have been annotated as bacitracin transport permeases, as it was suspected that they form the permease component of an ABC transporter system. It was shown, however, that BcrC from...; Region: PAP2_BcrC_like; cd03385 1100841000603 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 1100841000604 active site 1100841000605 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 1100841000606 Glutathionylspermidine synthase preATP-grasp; Region: GSP_synth; cl00503 1100841000607 Members of the ICL/PEPM_KPHMT enzyme superfamily catalyze the formation and cleavage of either P-C or C-C bonds. Typical members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate...; Region: ICL_KPHMT; cl00435 1100841000608 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 1100841000609 Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416 1100841000610 DNA polymerase III subunit beta; Validated; Region: PRK05643 1100841000611 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 1100841000612 dimer interface [polypeptide binding]; other site 1100841000613 putative DNA binding surface [nucleotide binding]; other site 1100841000614 beta-clamp/translesion DNA polymerase binding surface; other site 1100841000615 beta-clamp/clamp loader binding surface; other site 1100841000616 DnaA N-terminal domain; Region: DnaA_N; pfam11638 1100841000617 chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362 1100841000618 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1100841000619 Walker A motif; other site 1100841000620 ATP binding site [chemical binding]; other site 1100841000621 Walker B motif; other site 1100841000622 arginine finger; other site 1100841000623 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 1100841000624 DnaA box-binding interface [nucleotide binding]; other site 1100841000625 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 1100841000626 Ribonuclease P; Region: Ribonuclease_P; pfam00825 1100841000627 hypothetical protein; Provisional; Region: PRK14386 1100841000628 membrane protein insertase; Provisional; Region: PRK01318 1100841000629 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 1100841000630 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 1100841000631 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 1100841000632 trmE is a tRNA modification GTPase; Region: trmE; cd04164 1100841000633 G1 box; other site 1100841000634 GTP/Mg2+ binding site [chemical binding]; other site 1100841000635 Switch I region; other site 1100841000636 G2 box; other site 1100841000637 Switch II region; other site 1100841000638 G3 box; other site 1100841000639 G4 box; other site 1100841000640 G5 box; other site 1100841000641 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 1100841000642 Transcriptional regulators RcnR and FrmR, and related domains; this domain family was previously known as part of DUF156; Region: RcnR-FrmR-like_DUF156; cd10153 1100841000643 putative metal binding site [ion binding]; other site 1100841000644 putative homodimer interface [polypeptide binding]; other site 1100841000645 putative homotetramer interface [polypeptide binding]; other site 1100841000646 putative homodimer-homodimer interface [polypeptide binding]; other site 1100841000647 putative allosteric switch controlling residues; other site 1100841000648 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 1100841000649 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 1100841000650 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 1100841000651 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020 1100841000652 dimerization domain [polypeptide binding]; other site 1100841000653 dimer interface [polypeptide binding]; other site 1100841000654 catalytic residues [active] 1100841000655 Predicted membrane protein [Function unknown]; Region: COG2261 1100841000656 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1100841000657 active site 1100841000658 guanine deaminase; Provisional; Region: PRK09228 1100841000659 Guanine deaminase (GDEase). Guanine deaminase is an aminohydrolase responsible for the conversion of guanine to xanthine and ammonia, the first step to utilize guanine as a nitrogen source. This reaction also removes the guanine base from the pool and...; Region: GDEase; cd01303 1100841000660 active site 1100841000661 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 1100841000662 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 1100841000663 [2Fe-2S] cluster binding site [ion binding]; other site 1100841000664 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 1100841000665 hydrophobic ligand binding site; other site 1100841000666 Glutathionylspermidine synthase preATP-grasp; Region: GSP_synth; cl00503 1100841000667 recombination protein F; Reviewed; Region: recF; PRK00064 1100841000668 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1100841000669 Walker A/P-loop; other site 1100841000670 ATP binding site [chemical binding]; other site 1100841000671 Q-loop/lid; other site 1100841000672 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1100841000673 ABC transporter signature motif; other site 1100841000674 Walker B; other site 1100841000675 D-loop; other site 1100841000676 H-loop/switch region; other site 1100841000677 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 1100841000678 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1100841000679 ATP binding site [chemical binding]; other site 1100841000680 Mg2+ binding site [ion binding]; other site 1100841000681 G-X-G motif; other site 1100841000682 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 1100841000683 anchoring element; other site 1100841000684 dimer interface [polypeptide binding]; other site 1100841000685 ATP binding site [chemical binding]; other site 1100841000686 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 1100841000687 active site 1100841000688 putative metal-binding site [ion binding]; other site 1100841000689 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 1100841000690 Cytochrome b562; Region: Cytochrom_B562; pfam07361 1100841000691 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 1100841000692 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1100841000693 putative ABC transporter ATP-binding protein; Provisional; Region: PRK10636 1100841000694 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1100841000695 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1100841000696 ABC transporter; Region: ABC_tran_2; pfam12848 1100841000697 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1100841000698 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 1100841000699 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 1100841000700 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 1100841000701 iron-sulfur cluster insertion protein ErpA; Provisional; Region: PRK13623 1100841000702 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1100841000703 anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585 1100841000704 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 1100841000705 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 1100841000706 active site 1100841000707 HIGH motif; other site 1100841000708 dimer interface [polypeptide binding]; other site 1100841000709 KMSKS motif; other site 1100841000710 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1100841000711 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 1100841000712 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 1100841000713 Predicted flavoprotein [General function prediction only]; Region: COG0431 1100841000714 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1100841000715 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095 1100841000716 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1100841000717 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 1100841000718 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 1100841000719 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1100841000720 active site 1100841000721 HIGH motif; other site 1100841000722 nucleotide binding site [chemical binding]; other site 1100841000723 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1100841000724 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 1100841000725 active site 1100841000726 KMSKS motif; other site 1100841000727 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 1100841000728 tRNA binding surface [nucleotide binding]; other site 1100841000729 anticodon binding site; other site 1100841000730 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1100841000731 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 1100841000732 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 1100841000733 active site 1100841000734 Riboflavin kinase; Region: Flavokinase; smart00904 1100841000735 Tellurite resistance protein and related permeases [Inorganic ion transport and metabolism]; Region: TehA; COG1275 1100841000736 Tellurite-resistance/Dicarboxylate Transporter (TDT) family includes sulfite sensitivity protein (sulfite efflux pump; SSU1); Region: TDT_SSU1; cd09318 1100841000737 gating phenylalanine in ion channel; other site 1100841000738 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 1100841000739 pyrimidine utilization regulatory protein R; Region: RutR; TIGR03613 1100841000740 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1100841000741 YcdC-like protein, C-terminal region; Region: TetR_C_3; pfam08362 1100841000742 aliphatic sulfonates transport ATP-binding subunit; Provisional; Region: ssuB; PRK11247 1100841000743 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1100841000744 Walker A/P-loop; other site 1100841000745 ATP binding site [chemical binding]; other site 1100841000746 Q-loop/lid; other site 1100841000747 ABC transporter signature motif; other site 1100841000748 Walker B; other site 1100841000749 D-loop; other site 1100841000750 H-loop/switch region; other site 1100841000751 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1100841000752 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1100841000753 putative PBP binding loops; other site 1100841000754 dimer interface [polypeptide binding]; other site 1100841000755 ABC-ATPase subunit interface; other site 1100841000756 alkanesulfonate monooxygenase; Provisional; Region: PRK00719 1100841000757 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 1100841000758 active site 1100841000759 dimer interface [polypeptide binding]; other site 1100841000760 non-prolyl cis peptide bond; other site 1100841000761 insertion regions; other site 1100841000762 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 1100841000763 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1100841000764 substrate binding pocket [chemical binding]; other site 1100841000765 membrane-bound complex binding site; other site 1100841000766 hinge residues; other site 1100841000767 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 1100841000768 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1100841000769 substrate binding pocket [chemical binding]; other site 1100841000770 membrane-bound complex binding site; other site 1100841000771 hinge residues; other site 1100841000772 N-acetylglutamate synthase; Validated; Region: PRK05279 1100841000773 AAK_NAGS-ABP: N-acetylglutamate (NAG) kinase-like domain of the NAG Synthase (NAGS) of the arginine-biosynthesis pathway (ABP) found in gamma- and beta-proteobacteria and higher plant chloroplasts. Domain architecture of these NAGS consisted of an...; Region: AAK_NAGS-ABP; cd04237 1100841000774 putative feedback inhibition sensing region; other site 1100841000775 putative nucleotide binding site [chemical binding]; other site 1100841000776 putative substrate binding site [chemical binding]; other site 1100841000777 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1100841000778 Coenzyme A binding pocket [chemical binding]; other site 1100841000779 Domain of unknown function (DUF3315); Region: DUF3315; pfam11776 1100841000780 Domain of unknown function (DUF3315); Region: DUF3315; pfam11776 1100841000781 putative oxoacyl-(acyl carrier protein) reductase; Provisional; Region: PRK08945 1100841000782 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1100841000783 NAD(P) binding site [chemical binding]; other site 1100841000784 active site 1100841000785 phosphoglycolate phosphatase; Provisional; Region: PRK13222 1100841000786 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1100841000787 active site 1100841000788 motif I; other site 1100841000789 motif II; other site 1100841000790 bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134 1100841000791 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1100841000792 S-adenosylmethionine binding site [chemical binding]; other site 1100841000793 DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019 1100841000794 catalytic residues [active] 1100841000795 hinge region; other site 1100841000796 alpha helical domain; other site 1100841000797 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1100841000798 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1100841000799 DNA-binding transcriptional repressor FabR; Provisional; Region: PRK11202 1100841000800 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1100841000801 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_2; cd06216 1100841000802 FMN reductase; Validated; Region: fre; PRK08051 1100841000803 FAD binding pocket [chemical binding]; other site 1100841000804 FAD binding motif [chemical binding]; other site 1100841000805 phosphate binding motif [ion binding]; other site 1100841000806 beta-alpha-beta structure motif; other site 1100841000807 NAD binding pocket [chemical binding]; other site 1100841000808 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1100841000809 catalytic loop [active] 1100841000810 iron binding site [ion binding]; other site 1100841000811 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 1100841000812 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 1100841000813 putative di-iron ligands [ion binding]; other site 1100841000814 ribonuclease PH; Reviewed; Region: rph; PRK00173 1100841000815 Ribonuclease PH; Region: RNase_PH_bact; cd11362 1100841000816 hexamer interface [polypeptide binding]; other site 1100841000817 active site 1100841000818 phospholipase C, phosphocholine-specific, Pseudomonas-type; Region: PC_PLC; TIGR03396 1100841000819 Phosphoesterase family; Region: Phosphoesterase; pfam04185 1100841000820 Domain of unknown function (DUF756); Region: DUF756; pfam05506 1100841000821 Domain of unknown function (DUF756); Region: DUF756; pfam05506 1100841000822 quinolinate phosphoribosyltransferase; Validated; Region: PRK09016 1100841000823 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 1100841000824 dimerization interface [polypeptide binding]; other site 1100841000825 active site 1100841000826 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 1100841000827 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 1100841000828 amidase catalytic site [active] 1100841000829 Zn binding residues [ion binding]; other site 1100841000830 substrate binding site [chemical binding]; other site 1100841000831 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 1100841000832 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 1100841000833 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 1100841000834 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 1100841000835 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1100841000836 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 1100841000837 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 1100841000838 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1100841000839 tyrosine kinase; Provisional; Region: PRK11519 1100841000840 Chain length determinant protein; Region: Wzz; pfam02706 1100841000841 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 1100841000842 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1100841000843 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1100841000844 Low molecular weight phosphatase family; Region: LMWPc; cd00115 1100841000845 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 1100841000846 active site 1100841000847 polysaccharide export protein Wza; Provisional; Region: PRK15078 1100841000848 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 1100841000849 Vi polysaccharide biosynthesis protein TviB; Provisional; Region: PRK15182 1100841000850 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 1100841000851 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 1100841000852 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 1100841000853 dTDP-glucose 4,6 dehydratase; Provisional; Region: PRK10084 1100841000854 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 1100841000855 NAD binding site [chemical binding]; other site 1100841000856 substrate binding site [chemical binding]; other site 1100841000857 homodimer interface [polypeptide binding]; other site 1100841000858 active site 1100841000859 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 1100841000860 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 1100841000861 substrate binding site; other site 1100841000862 tetramer interface; other site 1100841000863 WxcM-like, C-terminal; Region: FdtA; pfam05523 1100841000864 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1100841000865 (R)-hydratase [(R)-specific enoyl-CoA hydratase] catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. (R)-hydratase contains a hot-dog fold similar to those of thioesterase...; Region: R_hydratase; cd03449 1100841000866 dimer interaction site [polypeptide binding]; other site 1100841000867 substrate-binding tunnel; other site 1100841000868 active site 1100841000869 catalytic site [active] 1100841000870 substrate binding site [chemical binding]; other site 1100841000871 DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041 1100841000872 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 1100841000873 inhibitor-cofactor binding pocket; inhibition site 1100841000874 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1100841000875 catalytic residue [active] 1100841000876 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_10; cd13125 1100841000877 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1100841000878 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1100841000879 active site 1100841000880 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1100841000881 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1100841000882 This family is most closely related to the GT1 family of glycosyltransferases. AmSD in Erwinia amylovora has been shown to be involved in the biosynthesis of amylovoran, the acidic exopolysaccharide acting as a virulence factor. This enzyme may be...; Region: GT1_amsD_like; cd03820 1100841000883 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1100841000884 putative ADP-binding pocket [chemical binding]; other site 1100841000885 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1100841000886 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 1100841000887 active site 1100841000888 Bacterial sugar transferase; Region: Bac_transf; pfam02397 1100841000889 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 1100841000890 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 1100841000891 active site 1100841000892 tetramer interface; other site 1100841000893 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 1100841000894 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 1100841000895 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 1100841000896 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 1100841000897 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 1100841000898 active site 1100841000899 dimer interface [polypeptide binding]; other site 1100841000900 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 1100841000901 dimer interface [polypeptide binding]; other site 1100841000902 active site 1100841000903 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 1100841000904 UDP-glucose 4-epimerase; Region: PLN02240 1100841000905 NAD binding site [chemical binding]; other site 1100841000906 homodimer interface [polypeptide binding]; other site 1100841000907 active site 1100841000908 substrate binding site [chemical binding]; other site 1100841000909 Sulfatase; Region: Sulfatase; pfam00884 1100841000910 phosphomannomutase CpsG; Provisional; Region: PRK15414 1100841000911 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 1100841000912 active site 1100841000913 substrate binding site [chemical binding]; other site 1100841000914 metal binding site [ion binding]; metal-binding site 1100841000915 L-lactate permease; Provisional; Region: PRK10420 1100841000916 glycolate transporter; Provisional; Region: PRK09695 1100841000917 DNA-binding transcriptional repressor LldR; Provisional; Region: PRK10421 1100841000918 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1100841000919 DNA-binding site [nucleotide binding]; DNA binding site 1100841000920 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 1100841000921 L-lactate dehydrogenase; Provisional; Region: lldD; PRK11197 1100841000922 Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809 1100841000923 active site 1100841000924 substrate binding site [chemical binding]; other site 1100841000925 FMN binding site [chemical binding]; other site 1100841000926 putative catalytic residues [active] 1100841000927 D-lactate dehydrogenase; Provisional; Region: PRK11183 1100841000928 FAD binding domain; Region: FAD_binding_4; pfam01565 1100841000929 D-lactate dehydrogenase, membrane binding; Region: Lact-deh-memb; pfam09330 1100841000930 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 1100841000931 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1100841000932 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1100841000933 homodimer interface [polypeptide binding]; other site 1100841000934 catalytic residue [active] 1100841000935 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1100841000936 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1100841000937 DNA-binding site [nucleotide binding]; DNA binding site 1100841000938 FCD domain; Region: FCD; pfam07729 1100841000939 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 1100841000940 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 1100841000941 tetramer interface [polypeptide binding]; other site 1100841000942 active site 1100841000943 Mg2+/Mn2+ binding site [ion binding]; other site 1100841000944 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 1100841000945 methylcitrate synthase; Provisional; Region: PRK12351 1100841000946 oxalacetate binding site [chemical binding]; other site 1100841000947 citrylCoA binding site [chemical binding]; other site 1100841000948 coenzyme A binding site [chemical binding]; other site 1100841000949 catalytic triad [active] 1100841000950 2-methylisocitrate dehydratase, Fe/S-dependent; Region: 2met_isocit_dHY; TIGR02333 1100841000951 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 1100841000952 substrate binding site [chemical binding]; other site 1100841000953 ligand binding site [chemical binding]; other site 1100841000954 Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215 1100841000955 substrate binding site [chemical binding]; other site 1100841000956 Domain of unknown function (DUF4126); Region: DUF4126; pfam13548 1100841000957 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1100841000958 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1100841000959 Coenzyme A binding pocket [chemical binding]; other site 1100841000960 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 1100841000961 nudix motif; other site 1100841000962 3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK07967 1100841000963 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1100841000964 dimer interface [polypeptide binding]; other site 1100841000965 active site 1100841000966 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1100841000967 NAD(P) binding site [chemical binding]; other site 1100841000968 active site 1100841000969 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1100841000970 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1100841000971 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1100841000972 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1100841000973 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1100841000974 Predicted membrane protein [Function unknown]; Region: COG4420 1100841000975 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1100841000976 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1100841000977 active site 1100841000978 Protein of unknown function (DUF1260); Region: DUF1260; pfam06877 1100841000979 SnoaL-like domain; Region: SnoaL_2; pfam12680 1100841000980 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 1100841000981 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1100841000982 N-terminal plug; other site 1100841000983 ligand-binding site [chemical binding]; other site 1100841000984 Predicted membrane protein [Function unknown]; Region: COG3503 1100841000985 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1100841000986 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1100841000987 putative DNA binding site [nucleotide binding]; other site 1100841000988 putative Zn2+ binding site [ion binding]; other site 1100841000989 AsnC family; Region: AsnC_trans_reg; pfam01037 1100841000990 D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711 1100841000991 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1100841000992 mRNA stabilisation; Region: mRNA_stabil; pfam13929 1100841000993 alanine racemase; Reviewed; Region: dadX; PRK03646 1100841000994 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827 1100841000995 active site 1100841000996 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1100841000997 substrate binding site [chemical binding]; other site 1100841000998 catalytic residues [active] 1100841000999 dimer interface [polypeptide binding]; other site 1100841001000 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150 1100841001001 homotrimer interaction site [polypeptide binding]; other site 1100841001002 putative active site [active] 1100841001003 D-alanine/D-serine/glycine permease; Provisional; Region: PRK11049 1100841001004 D-alanine/D-serine/glycine permease; Provisional; Region: PRK11049 1100841001005 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1100841001006 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1100841001007 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1100841001008 dimerization interface [polypeptide binding]; other site 1100841001009 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 1100841001010 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 1100841001011 tetrameric interface [polypeptide binding]; other site 1100841001012 NAD binding site [chemical binding]; other site 1100841001013 catalytic residues [active] 1100841001014 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1100841001015 3-hydroxyisobutyrate dehydrogenase; Region: HIBADH; TIGR01692 1100841001016 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 1100841001017 Domain of unknown function (DUF3448); Region: DUF3448; pfam11930 1100841001018 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1100841001019 acyl-activating enzyme (AAE) consensus motif; other site 1100841001020 AMP binding site [chemical binding]; other site 1100841001021 active site 1100841001022 CoA binding site [chemical binding]; other site 1100841001023 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1100841001024 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1100841001025 active site 1100841001026 enoyl-CoA hydratase; Provisional; Region: PRK05862 1100841001027 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1100841001028 substrate binding site [chemical binding]; other site 1100841001029 oxyanion hole (OAH) forming residues; other site 1100841001030 trimer interface [polypeptide binding]; other site 1100841001031 3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617 1100841001032 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1100841001033 substrate binding site [chemical binding]; other site 1100841001034 oxyanion hole (OAH) forming residues; other site 1100841001035 trimer interface [polypeptide binding]; other site 1100841001036 2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766 1100841001037 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1100841001038 metabolite-proton symporter; Region: 2A0106; TIGR00883 1100841001039 putative substrate translocation pore; other site 1100841001040 Autoinducer synthetase; Region: Autoind_synth; cl17404 1100841001041 DNA-binding transcriptional activator SdiA; Provisional; Region: PRK10188 1100841001042 Autoinducer binding domain; Region: Autoind_bind; pfam03472 1100841001043 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1100841001044 DNA binding residues [nucleotide binding] 1100841001045 dimerization interface [polypeptide binding]; other site 1100841001046 acyl-CoA synthetase; Validated; Region: PRK05850 1100841001047 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 1100841001048 acyl-activating enzyme (AAE) consensus motif; other site 1100841001049 active site 1100841001050 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1100841001051 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 1100841001052 active site 1100841001053 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1100841001054 potential frameshift: common BLAST hit: gi|384141390|ref|YP_005524100.1| non-ribosomal peptide synthetase protein 1100841001055 Condensation domain; Region: Condensation; pfam00668 1100841001056 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1100841001057 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1100841001058 The adenylation domain of nonribosomal peptide synthetases (NRPS), including salinosporamide A polyketide synthase; Region: A_NRPS_Ta1_like; cd12116 1100841001059 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 1100841001060 acyl-activating enzyme (AAE) consensus motif; other site 1100841001061 AMP binding site [chemical binding]; other site 1100841001062 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1100841001063 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 1100841001064 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 1100841001065 hydrophobic ligand binding site; other site 1100841001066 Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033 1100841001067 Protein of unknown function (DUF1329); Region: DUF1329; pfam07044 1100841001068 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1100841001069 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 1100841001070 NAD(P) binding site [chemical binding]; other site 1100841001071 active site 1100841001072 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1100841001073 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 1100841001074 catalytic site [active] 1100841001075 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 1100841001076 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 1100841001077 Stress-induced morphogen (activity unknown) [Signal transduction mechanisms]; Region: BolA; COG0271 1100841001078 Condensation domain; Region: Condensation; pfam00668 1100841001079 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399 1100841001080 Predicted membrane protein [Function unknown]; Region: COG2259 1100841001081 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 1100841001082 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1100841001083 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 1100841001084 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1100841001085 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1100841001086 P-loop; other site 1100841001087 Magnesium ion binding site [ion binding]; other site 1100841001088 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1100841001089 Magnesium ion binding site [ion binding]; other site 1100841001090 Invasion gene expression up-regulator, SirB; Region: SirB; cl01184 1100841001091 Stress-induced morphogen (activity unknown) [Signal transduction mechanisms]; Region: BolA; COG0271 1100841001092 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 1100841001093 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 1100841001094 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1100841001095 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 1100841001096 NAD(P) binding site [chemical binding]; other site 1100841001097 active site 1100841001098 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1100841001099 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 1100841001100 catalytic site [active] 1100841001101 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 1100841001102 hydrophobic ligand binding site; other site 1100841001103 Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033 1100841001104 Protein of unknown function (DUF1329); Region: DUF1329; pfam07044 1100841001105 potential frameshift: common BLAST hit: gi|385235691|ref|YP_005797030.1| non-ribosomal peptide synthetase protein 1100841001106 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1100841001107 The adenylation domain of nonribosomal peptide synthetases (NRPS), including salinosporamide A polyketide synthase; Region: A_NRPS_Ta1_like; cd12116 1100841001108 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 1100841001109 acyl-activating enzyme (AAE) consensus motif; other site 1100841001110 AMP binding site [chemical binding]; other site 1100841001111 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1100841001112 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 1100841001113 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1100841001114 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 1100841001115 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1100841001116 Q-loop/lid; other site 1100841001117 ABC transporter signature motif; other site 1100841001118 Walker B; other site 1100841001119 D-loop; other site 1100841001120 H-loop/switch region; other site 1100841001121 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cl17326 1100841001122 metal binding site 2 [ion binding]; metal-binding site 1100841001123 putative DNA binding helix; other site 1100841001124 metal binding site 1 [ion binding]; metal-binding site 1100841001125 dimer interface [polypeptide binding]; other site 1100841001126 structural Zn2+ binding site [ion binding]; other site 1100841001127 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 1100841001128 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1100841001129 intersubunit interface [polypeptide binding]; other site 1100841001130 F0F1 ATP synthase subunit I; Validated; Region: PRK05760 1100841001131 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 1100841001132 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 1100841001133 F0F1 ATP synthase subunit C; Validated; Region: PRK06876 1100841001134 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 1100841001135 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 1100841001136 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 1100841001137 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 1100841001138 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 1100841001139 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1100841001140 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1100841001141 Walker A motif; other site 1100841001142 ATP binding site [chemical binding]; other site 1100841001143 Walker B motif; other site 1100841001144 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1100841001145 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 1100841001146 core domain interface [polypeptide binding]; other site 1100841001147 delta subunit interface [polypeptide binding]; other site 1100841001148 epsilon subunit interface [polypeptide binding]; other site 1100841001149 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 1100841001150 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1100841001151 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 1100841001152 alpha subunit interaction interface [polypeptide binding]; other site 1100841001153 Walker A motif; other site 1100841001154 ATP binding site [chemical binding]; other site 1100841001155 Walker B motif; other site 1100841001156 inhibitor binding site; inhibition site 1100841001157 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1100841001158 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 1100841001159 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 1100841001160 gamma subunit interface [polypeptide binding]; other site 1100841001161 epsilon subunit interface [polypeptide binding]; other site 1100841001162 LBP interface [polypeptide binding]; other site 1100841001163 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 1100841001164 catalytic residues [active] 1100841001165 dimer interface [polypeptide binding]; other site 1100841001166 Helix-turn-helix domain; Region: HTH_18; pfam12833 1100841001167 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1100841001168 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1100841001169 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1100841001170 putative substrate translocation pore; other site 1100841001171 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1100841001172 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1100841001173 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1100841001174 EamA-like transporter family; Region: EamA; pfam00892 1100841001175 EamA-like transporter family; Region: EamA; pfam00892 1100841001176 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 1100841001177 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 1100841001178 DNA protecting protein DprA; Region: dprA; TIGR00732 1100841001179 Uncharacterized protein containing LysM domain [Function unknown]; Region: XkdP; COG1652 1100841001180 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1100841001181 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 1100841001182 active site 1100841001183 catalytic residues [active] 1100841001184 metal binding site [ion binding]; metal-binding site 1100841001185 TonB-dependent copper receptor; Region: TonB-copper; TIGR01778 1100841001186 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1100841001187 N-terminal plug; other site 1100841001188 ligand-binding site [chemical binding]; other site 1100841001189 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; pfam09995 1100841001190 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1100841001191 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1100841001192 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1100841001193 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1100841001194 active site 1100841001195 catalytic tetrad [active] 1100841001196 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1100841001197 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1100841001198 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA; cd08478 1100841001199 putative effector binding pocket; other site 1100841001200 dimerization interface [polypeptide binding]; other site 1100841001201 membrane-bound lytic murein transglycosylase D; Provisional; Region: mltD; PRK10783 1100841001202 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1100841001203 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1100841001204 DNA-binding site [nucleotide binding]; DNA binding site 1100841001205 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1100841001206 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1100841001207 homodimer interface [polypeptide binding]; other site 1100841001208 catalytic residue [active] 1100841001209 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 1100841001210 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 1100841001211 putative NAD(P) binding site [chemical binding]; other site 1100841001212 putative substrate binding site [chemical binding]; other site 1100841001213 catalytic Zn binding site [ion binding]; other site 1100841001214 structural Zn binding site [ion binding]; other site 1100841001215 dimer interface [polypeptide binding]; other site 1100841001216 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 1100841001217 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1100841001218 Peptidase family M23; Region: Peptidase_M23; pfam01551 1100841001219 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 1100841001220 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1100841001221 minor groove reading motif; other site 1100841001222 helix-hairpin-helix signature motif; other site 1100841001223 substrate binding pocket [chemical binding]; other site 1100841001224 active site 1100841001225 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 1100841001226 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 1100841001227 DNA binding and oxoG recognition site [nucleotide binding] 1100841001228 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 1100841001229 nucleotide binding site/active site [active] 1100841001230 HIT family signature motif; other site 1100841001231 catalytic residue [active] 1100841001232 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 1100841001233 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1100841001234 Small integral membrane protein [Function unknown]; Region: COG5487; cl17674 1100841001235 hypothetical protein; Provisional; Region: PRK05170 1100841001236 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 1100841001237 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 1100841001238 recombination factor protein RarA; Reviewed; Region: PRK13342 1100841001239 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1100841001240 Walker A motif; other site 1100841001241 ATP binding site [chemical binding]; other site 1100841001242 Walker B motif; other site 1100841001243 arginine finger; other site 1100841001244 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 1100841001245 Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226 1100841001246 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 1100841001247 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 1100841001248 ATP binding site [chemical binding]; other site 1100841001249 active site 1100841001250 substrate binding site [chemical binding]; other site 1100841001251 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 1100841001252 dihydrodipicolinate synthase; Region: dapA; TIGR00674 1100841001253 dimer interface [polypeptide binding]; other site 1100841001254 active site 1100841001255 catalytic residue [active] 1100841001256 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 1100841001257 Isochorismatase family; Region: Isochorismatase; pfam00857 1100841001258 catalytic triad [active] 1100841001259 metal binding site [ion binding]; metal-binding site 1100841001260 conserved cis-peptide bond; other site 1100841001261 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 1100841001262 Sodium Bile acid symporter family; Region: SBF; pfam01758 1100841001263 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 1100841001264 putative efflux protein, MATE family; Region: matE; TIGR00797 1100841001265 cation binding site [ion binding]; other site 1100841001266 Uncharacterized conserved protein [Function unknown]; Region: COG1683 1100841001267 4-hydroxyphenylpyruvate dioxygenase and related hemolysins [Amino acid transport and metabolism / General function prediction only]; Region: COG3185 1100841001268 N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342 1100841001269 dimer interface [polypeptide binding]; other site 1100841001270 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250 1100841001271 active site 1100841001272 Fe binding site [ion binding]; other site 1100841001273 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 1100841001274 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1100841001275 Bacterial transcriptional regulator; Region: IclR; pfam01614 1100841001276 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1100841001277 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 1100841001278 Zn binding site [ion binding]; other site 1100841001279 GST_N family, Class Zeta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Zeta; cd03042 1100841001280 maleylacetoacetate isomerase; Region: maiA; TIGR01262 1100841001281 C-terminal domain interface [polypeptide binding]; other site 1100841001282 GSH binding site (G-site) [chemical binding]; other site 1100841001283 putative dimer interface [polypeptide binding]; other site 1100841001284 C-terminal, alpha helical domain of Class Zeta Glutathione S-transferases; Region: GST_C_Zeta; cd03191 1100841001285 dimer interface [polypeptide binding]; other site 1100841001286 N-terminal domain interface [polypeptide binding]; other site 1100841001287 maleylacetoacetate (MAA) substrate binding site (H site) [chemical binding]; other site 1100841001288 fumarylacetoacetase; Region: fum_ac_acetase; TIGR01266 1100841001289 The Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT; cl04176 1100841001290 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 1100841001291 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cl00148 1100841001292 primary dimer interface [polypeptide binding]; other site 1100841001293 Long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07059 1100841001294 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1100841001295 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 1100841001296 acyl-activating enzyme (AAE) consensus motif; other site 1100841001297 putative AMP binding site [chemical binding]; other site 1100841001298 putative active site [active] 1100841001299 putative CoA binding site [chemical binding]; other site 1100841001300 MAPEG family; Region: MAPEG; cl09190 1100841001301 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 1100841001302 dimer interface [polypeptide binding]; other site 1100841001303 substrate binding site [chemical binding]; other site 1100841001304 metal binding sites [ion binding]; metal-binding site 1100841001305 outer membrane porin, OprD family; Region: OprD; pfam03573 1100841001306 Bacterial protein of unknown function (Gcw_chp); Region: Gcw_chp; cl09901 1100841001307 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 1100841001308 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 1100841001309 inhibitor site; inhibition site 1100841001310 active site 1100841001311 dimer interface [polypeptide binding]; other site 1100841001312 catalytic residue [active] 1100841001313 class II aldolase/adducin domain protein; Provisional; Region: PRK07090 1100841001314 intersubunit interface [polypeptide binding]; other site 1100841001315 active site 1100841001316 Zn2+ binding site [ion binding]; other site 1100841001317 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1100841001318 DNA-binding site [nucleotide binding]; DNA binding site 1100841001319 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1100841001320 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1100841001321 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1100841001322 homodimer interface [polypeptide binding]; other site 1100841001323 catalytic residue [active] 1100841001324 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 1100841001325 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 1100841001326 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 1100841001327 TnsA endonuclease N terminal; Region: Tn7_Tnp_TnsA_N; pfam08722 1100841001328 Helix-turn-helix domain; Region: HTH_28; pfam13518 1100841001329 Integrase core domain; Region: rve; pfam00665 1100841001330 Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299 1100841001331 Bacterial TniB protein; Region: TniB; pfam05621 1100841001332 AAA domain; Region: AAA_22; pfam13401 1100841001333 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1100841001334 Ligand Binding Site [chemical binding]; other site 1100841001335 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1100841001336 Ligand Binding Site [chemical binding]; other site 1100841001337 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 1100841001338 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 1100841001339 Sulfate transporter family; Region: Sulfate_transp; pfam00916 1100841001340 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 1100841001341 AAA domain; Region: AAA_33; pfam13671 1100841001342 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4185 1100841001343 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 1100841001344 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1100841001345 active site 1100841001346 DNA binding site [nucleotide binding] 1100841001347 Int/Topo IB signature motif; other site 1100841001348 TnsA endonuclease N terminal; Region: Tn7_Tnp_TnsA_N; pfam08722 1100841001349 potential frameshift: common BLAST hit: gi|384130211|ref|YP_005512823.1| transposase 1100841001350 Helix-turn-helix domain; Region: HTH_28; pfam13518 1100841001351 Integrase core domain; Region: rve; pfam00665 1100841001352 Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299 1100841001353 Bacterial TniB protein; Region: TniB; pfam05621 1100841001354 dihydropteroate synthase; Region: DHPS; TIGR01496 1100841001355 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 1100841001356 substrate binding pocket [chemical binding]; other site 1100841001357 dimer interface [polypeptide binding]; other site 1100841001358 inhibitor binding site; inhibition site 1100841001359 The alpha-D-phosphohexomutase superfamily includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this family include the phosphoglucomutases (PGM1 and PGM2), phosphoglucosamine...; Region: phosphohexomutase; cl03757 1100841001360 TnsA endonuclease N terminal; Region: Tn7_Tnp_TnsA_N; pfam08722 1100841001361 Helix-turn-helix domain; Region: HTH_28; pfam13518 1100841001362 Integrase core domain; Region: rve; pfam00665 1100841001363 Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299 1100841001364 Bacterial TniB protein; Region: TniB; pfam05621 1100841001365 AAA domain; Region: AAA_22; pfam13401 1100841001366 formamidopyrimidine-DNA glycosylase; Provisional; Region: PRK14811 1100841001367 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1100841001368 Ligand Binding Site [chemical binding]; other site 1100841001369 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1100841001370 Ligand Binding Site [chemical binding]; other site 1100841001371 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 1100841001372 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 1100841001373 Sulfate transporter family; Region: Sulfate_transp; pfam00916 1100841001374 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 1100841001375 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1100841001376 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1100841001377 putative substrate translocation pore; other site 1100841001378 tetracycline repressor protein TetR; Provisional; Region: PRK13756 1100841001379 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1100841001380 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 1100841001381 Transposase zinc-binding domain; Region: Zn_Tnp_IS91; pfam14319 1100841001382 Putative transposase; Region: Y2_Tnp; pfam04986 1100841001383 Aminoglycoside/hydroxyurea antibiotic resistance kinase; Region: APH_6_hur; pfam04655 1100841001384 Aminoglycoside 3'-phosphotransferase (APH). The APH subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin...; Region: APH; cd05150 1100841001385 Phosphotransferase enzyme family; Region: APH; pfam01636 1100841001386 active site 1100841001387 ATP binding site [chemical binding]; other site 1100841001388 antibiotic binding site [chemical binding]; other site 1100841001389 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 1100841001390 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 1100841001391 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 1100841001392 Membrane fusogenic activity; Region: BMFP; pfam04380 1100841001393 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 1100841001394 Nitrogen regulatory protein P-II; Region: P-II; smart00938 1100841001395 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 1100841001396 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 1100841001397 ATP cone domain; Region: ATP-cone; pfam03477 1100841001398 bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase; Provisional; Region: ribD; PRK10786 1100841001399 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 1100841001400 catalytic motif [active] 1100841001401 Zn binding site [ion binding]; other site 1100841001402 RibD C-terminal domain; Region: RibD_C; cl17279 1100841001403 Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG3392 1100841001404 D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; cl17344 1100841001405 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 1100841001406 Lumazine binding domain; Region: Lum_binding; pfam00677 1100841001407 Lumazine binding domain; Region: Lum_binding; pfam00677 1100841001408 DNA polymerase III chi subunit, HolC; Region: DNA_pol3_chi; pfam04364 1100841001409 multifunctional aminopeptidase A; Provisional; Region: PRK00913 1100841001410 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 1100841001411 interface (dimer of trimers) [polypeptide binding]; other site 1100841001412 Substrate-binding/catalytic site; other site 1100841001413 Zn-binding sites [ion binding]; other site 1100841001414 Predicted permeases [General function prediction only]; Region: COG0795; cl12074 1100841001415 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 1100841001416 Predicted permeases [General function prediction only]; Region: COG0795; cl12074 1100841001417 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 1100841001418 phosphoglyceromutase; Provisional; Region: PRK05434 1100841001419 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 1100841001420 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 1100841001421 C-terminal peptidase (prc); Region: prc; TIGR00225 1100841001422 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cd00136 1100841001423 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 1100841001424 Catalytic dyad [active] 1100841001425 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 1100841001426 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1100841001427 active site 1100841001428 phosphorylation site [posttranslational modification] 1100841001429 intermolecular recognition site; other site 1100841001430 dimerization interface [polypeptide binding]; other site 1100841001431 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1100841001432 Walker A motif; other site 1100841001433 ATP binding site [chemical binding]; other site 1100841001434 Walker B motif; other site 1100841001435 arginine finger; other site 1100841001436 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1100841001437 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 1100841001438 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 1100841001439 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1100841001440 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1100841001441 dimer interface [polypeptide binding]; other site 1100841001442 phosphorylation site [posttranslational modification] 1100841001443 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1100841001444 ATP binding site [chemical binding]; other site 1100841001445 Mg2+ binding site [ion binding]; other site 1100841001446 G-X-G motif; other site 1100841001447 response regulator; Provisional; Region: PRK09483 1100841001448 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1100841001449 active site 1100841001450 phosphorylation site [posttranslational modification] 1100841001451 intermolecular recognition site; other site 1100841001452 dimerization interface [polypeptide binding]; other site 1100841001453 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1100841001454 DNA binding residues [nucleotide binding] 1100841001455 dimerization interface [polypeptide binding]; other site 1100841001456 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1100841001457 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 1100841001458 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 1100841001459 homodimer interface [polypeptide binding]; other site 1100841001460 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1100841001461 catalytic residue [active] 1100841001462 homoserine dehydrogenase; Provisional; Region: PRK06349 1100841001463 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 1100841001464 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 1100841001465 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 1100841001466 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 1100841001467 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020 1100841001468 dimerization domain [polypeptide binding]; other site 1100841001469 dimer interface [polypeptide binding]; other site 1100841001470 catalytic residues [active] 1100841001471 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 1100841001472 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 1100841001473 active site 1100841001474 Int/Topo IB signature motif; other site 1100841001475 FeoA domain; Region: FeoA; pfam04023 1100841001476 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 1100841001477 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 1100841001478 G1 box; other site 1100841001479 GTP/Mg2+ binding site [chemical binding]; other site 1100841001480 Switch I region; other site 1100841001481 G2 box; other site 1100841001482 G3 box; other site 1100841001483 Switch II region; other site 1100841001484 G4 box; other site 1100841001485 G5 box; other site 1100841001486 Nucleoside recognition; Region: Gate; pfam07670 1100841001487 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 1100841001488 Nucleoside recognition; Region: Gate; pfam07670 1100841001489 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK03803 1100841001490 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1100841001491 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1100841001492 cell division protein FtsW; Region: ftsW; TIGR02614 1100841001493 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1100841001494 active site 1100841001495 KMSKS motif; other site 1100841001496 RNA polymerase-binding protein DksA; Region: dksA; TIGR02420 1100841001497 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 1100841001498 hexamer interface [polypeptide binding]; other site 1100841001499 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1100841001500 active site 1100841001501 metal binding site [ion binding]; metal-binding site 1100841001502 ADP-ribose pyrophosphatase NudF; Provisional; Region: nudF; PRK10729 1100841001503 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 1100841001504 dimer interface [polypeptide binding]; other site 1100841001505 ADP-ribose binding site [chemical binding]; other site 1100841001506 active site 1100841001507 nudix motif; other site 1100841001508 metal binding site [ion binding]; metal-binding site 1100841001509 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 1100841001510 ThiC-associated domain; Region: ThiC-associated; pfam13667 1100841001511 Thiamine biosynthesis protein ThiC [Coenzyme metabolism]; Region: ThiC; COG0422 1100841001512 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1100841001513 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1100841001514 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 1100841001515 EamA-like transporter family; Region: EamA; pfam00892 1100841001516 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 1100841001517 transcriptional regulator PhoU; Provisional; Region: PRK11115 1100841001518 PhoU domain; Region: PhoU; pfam01895 1100841001519 PhoU domain; Region: PhoU; pfam01895 1100841001520 oxidative damage protection protein; Provisional; Region: PRK05408 1100841001521 argininosuccinate lyase; Provisional; Region: PRK00855 1100841001522 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 1100841001523 active sites [active] 1100841001524 tetramer interface [polypeptide binding]; other site 1100841001525 Histidine kinase; Region: His_kinase; pfam06580 1100841001526 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 1100841001527 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1100841001528 active site 1100841001529 phosphorylation site [posttranslational modification] 1100841001530 intermolecular recognition site; other site 1100841001531 dimerization interface [polypeptide binding]; other site 1100841001532 LytTr DNA-binding domain; Region: LytTR; smart00850 1100841001533 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 1100841001534 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 1100841001535 domain interfaces; other site 1100841001536 active site 1100841001537 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 1100841001538 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 1100841001539 active site 1100841001540 heme biosynthesis-associated TPR protein; Region: TPR_hemY_coli; TIGR00540 1100841001541 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1100841001542 active site 1100841001543 H-NS histone family; Region: Histone_HNS; pfam00816 1100841001544 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 1100841001545 Type II secretion system (T2SS), protein N; Region: T2SN; pfam01203 1100841001546 type II secretion system protein C; Region: typeII_sec_gspC; TIGR01713 1100841001547 Type IV pilus biogenesis; Region: Pilus_PilP; pfam11356 1100841001548 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1100841001549 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 1100841001550 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 1100841001551 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 1100841001552 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 1100841001553 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1100841001554 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1100841001555 phosphopeptide binding site; other site 1100841001556 phosphoglycolate phosphatase; Provisional; Region: PRK13222 1100841001557 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1100841001558 motif II; other site 1100841001559 anthranilate synthase component I; Provisional; Region: PRK13565 1100841001560 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 1100841001561 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 1100841001562 elongation factor Tu; Reviewed; Region: PRK00049 1100841001563 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 1100841001564 G1 box; other site 1100841001565 GEF interaction site [polypeptide binding]; other site 1100841001566 GTP/Mg2+ binding site [chemical binding]; other site 1100841001567 Switch I region; other site 1100841001568 G2 box; other site 1100841001569 G3 box; other site 1100841001570 Switch II region; other site 1100841001571 G4 box; other site 1100841001572 G5 box; other site 1100841001573 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 1100841001574 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 1100841001575 Antibiotic Binding Site [chemical binding]; other site 1100841001576 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK05740 1100841001577 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 1100841001578 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 1100841001579 putative homodimer interface [polypeptide binding]; other site 1100841001580 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 1100841001581 heterodimer interface [polypeptide binding]; other site 1100841001582 homodimer interface [polypeptide binding]; other site 1100841001583 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 1100841001584 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 1100841001585 23S rRNA interface [nucleotide binding]; other site 1100841001586 L7/L12 interface [polypeptide binding]; other site 1100841001587 putative thiostrepton binding site; other site 1100841001588 L25 interface [polypeptide binding]; other site 1100841001589 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 1100841001590 mRNA/rRNA interface [nucleotide binding]; other site 1100841001591 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 1100841001592 23S rRNA interface [nucleotide binding]; other site 1100841001593 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 1100841001594 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 1100841001595 core dimer interface [polypeptide binding]; other site 1100841001596 peripheral dimer interface [polypeptide binding]; other site 1100841001597 L10 interface [polypeptide binding]; other site 1100841001598 L11 interface [polypeptide binding]; other site 1100841001599 putative EF-Tu interaction site [polypeptide binding]; other site 1100841001600 putative EF-G interaction site [polypeptide binding]; other site 1100841001601 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 1100841001602 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 1100841001603 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 1100841001604 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 1100841001605 RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562 1100841001606 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 1100841001607 RPB1 interaction site [polypeptide binding]; other site 1100841001608 RPB11 interaction site [polypeptide binding]; other site 1100841001609 RPB10 interaction site [polypeptide binding]; other site 1100841001610 RPB3 interaction site [polypeptide binding]; other site 1100841001611 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 1100841001612 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 1100841001613 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 1100841001614 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 1100841001615 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 1100841001616 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 1100841001617 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 1100841001618 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 1100841001619 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 1100841001620 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 1100841001621 DNA binding site [nucleotide binding] 1100841001622 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 1100841001623 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1100841001624 active site 2 [active] 1100841001625 active site 1 [active] 1100841001626 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1100841001627 Putative serine esterase (DUF676); Region: DUF676; pfam05057 1100841001628 Predicted permease [General function prediction only]; Region: COG2056 1100841001629 Na+-H+ antiporter family; Region: Na_H_antiport_2; pfam13726 1100841001630 Outer membrane protein W [Cell envelope biogenesis, outer membrane]; Region: OmpW; COG3047 1100841001631 Protein of unknown function (DUF1311); Region: DUF1311; pfam07007 1100841001632 heat shock protein 90; Provisional; Region: PRK05218 1100841001633 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1100841001634 ATP binding site [chemical binding]; other site 1100841001635 Mg2+ binding site [ion binding]; other site 1100841001636 G-X-G motif; other site 1100841001637 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 1100841001638 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 1100841001639 catalytic residues [active] 1100841001640 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 1100841001641 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1100841001642 DNA binding residues [nucleotide binding] 1100841001643 Predicted esterase of the alpha/beta hydrolase fold [General function prediction only]; Region: COG3545 1100841001644 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1100841001645 hypothetical protein; Provisional; Region: PRK10215 1100841001646 3-ketoacyl-CoA thiolase; Reviewed; Region: fadA; PRK08947 1100841001647 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1100841001648 dimer interface [polypeptide binding]; other site 1100841001649 active site 1100841001650 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadB; PRK11730 1100841001651 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1100841001652 substrate binding site [chemical binding]; other site 1100841001653 oxyanion hole (OAH) forming residues; other site 1100841001654 trimer interface [polypeptide binding]; other site 1100841001655 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1100841001656 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1100841001657 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1100841001658 Aspartyl/asparaginyl beta-hydroxylase and related dioxygenases [Posttranslational modification, protein turnover, chaperones]; Region: COG3555 1100841001659 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 1100841001660 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 1100841001661 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 1100841001662 GIY-YIG motif/motif A; other site 1100841001663 active site 1100841001664 catalytic site [active] 1100841001665 putative DNA binding site [nucleotide binding]; other site 1100841001666 metal binding site [ion binding]; metal-binding site 1100841001667 UvrB/uvrC motif; Region: UVR; pfam02151 1100841001668 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 1100841001669 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 1100841001670 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 1100841001671 active site 1100841001672 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II; cd00556 1100841001673 active site 1100841001674 dimer interface [polypeptide binding]; other site 1100841001675 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 1100841001676 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1100841001677 Helix-turn-helix domain; Region: HTH_18; pfam12833 1100841001678 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 1100841001679 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1100841001680 DNA binding site [nucleotide binding] 1100841001681 active site 1100841001682 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_2; pfam13532 1100841001683 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 1100841001684 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1100841001685 Bacterial transcriptional regulator; Region: IclR; pfam01614 1100841001686 Fusaric acid resistance protein family; Region: FUSC; pfam04632 1100841001687 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 1100841001688 Protein of unknown function (DUF1656); Region: DUF1656; pfam07869 1100841001689 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 1100841001690 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1100841001691 HlyD family secretion protein; Region: HlyD_3; pfam13437 1100841001692 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 1100841001693 Uncharacterized ACR, COG1678; Region: DUF179; pfam02622 1100841001694 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 1100841001695 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 1100841001696 Walker A/P-loop; other site 1100841001697 ATP binding site [chemical binding]; other site 1100841001698 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 1100841001699 ABC transporter signature motif; other site 1100841001700 Walker B; other site 1100841001701 D-loop; other site 1100841001702 H-loop/switch region; other site 1100841001703 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1100841001704 binding surface 1100841001705 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1100841001706 TPR motif; other site 1100841001707 Protein of unknown function (DUF1255); Region: DUF1255; pfam06865 1100841001708 23S rRNA (guanosine-2'-O-)-methyltransferase; Provisional; Region: PRK11181 1100841001709 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 1100841001710 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1100841001711 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1100841001712 EamA-like transporter family; Region: EamA; pfam00892 1100841001713 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 1100841001714 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 1100841001715 CoA-binding site [chemical binding]; other site 1100841001716 ATP-binding [chemical binding]; other site 1100841001717 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 1100841001718 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 1100841001719 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 1100841001720 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 1100841001721 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1100841001722 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1100841001723 type IV-A pilus assembly ATPase PilB; Region: type_IV_pilB; TIGR02538 1100841001724 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 1100841001725 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 1100841001726 Walker A motif; other site 1100841001727 ATP binding site [chemical binding]; other site 1100841001728 Walker B motif; other site 1100841001729 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 1100841001730 triosephosphate isomerase; Provisional; Region: PRK14567 1100841001731 substrate binding site [chemical binding]; other site 1100841001732 dimer interface [polypeptide binding]; other site 1100841001733 catalytic triad [active] 1100841001734 Preprotein translocase SecG subunit; Region: SecG; pfam03840 1100841001735 Sm and related proteins; Region: Sm_like; cl00259 1100841001736 ribosome maturation protein RimP; Reviewed; Region: PRK00092 1100841001737 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 1100841001738 putative oligomer interface [polypeptide binding]; other site 1100841001739 putative RNA binding site [nucleotide binding]; other site 1100841001740 transcription elongation factor NusA; Validated; Region: nusA; PRK09202 1100841001741 NusA N-terminal domain; Region: NusA_N; pfam08529 1100841001742 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 1100841001743 RNA binding site [nucleotide binding]; other site 1100841001744 homodimer interface [polypeptide binding]; other site 1100841001745 NusA-like KH domain; Region: KH_5; pfam13184 1100841001746 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 1100841001747 G-X-X-G motif; other site 1100841001748 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 1100841001749 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 1100841001750 translation initiation factor IF-2; Region: IF-2; TIGR00487 1100841001751 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 1100841001752 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 1100841001753 G1 box; other site 1100841001754 putative GEF interaction site [polypeptide binding]; other site 1100841001755 GTP/Mg2+ binding site [chemical binding]; other site 1100841001756 Switch I region; other site 1100841001757 G2 box; other site 1100841001758 G3 box; other site 1100841001759 Switch II region; other site 1100841001760 G4 box; other site 1100841001761 G5 box; other site 1100841001762 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 1100841001763 Translation-initiation factor 2; Region: IF-2; pfam11987 1100841001764 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 1100841001765 ribosome-binding factor A; Provisional; Region: PRK13816 1100841001766 putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12674 1100841001767 Multiple resistance and pH regulation protein F (MrpF / PhaF); Region: MrpF_PhaF; cl09154 1100841001768 putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK08965 1100841001769 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12666 1100841001770 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1100841001771 putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK09094 1100841001772 putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12648 1100841001773 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1100841001774 Domain of unknown function (DUF4040); Region: DUF4040; pfam13244 1100841001775 Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111 1100841001776 putative monovalent cation/H+ antiporter subunit B; Reviewed; Region: PRK12573 1100841001777 AAA domain; Region: AAA_23; pfam13476 1100841001778 Family description; Region: UvrD_C_2; pfam13538 1100841001779 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 1100841001780 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 1100841001781 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 1100841001782 metal binding site [ion binding]; metal-binding site 1100841001783 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 1100841001784 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1100841001785 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1100841001786 ABC1 family; Region: ABC1; cl17513 1100841001787 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 1100841001788 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3165 1100841001789 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 1100841001790 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1100841001791 S-adenosylmethionine binding site [chemical binding]; other site 1100841001792 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4627 1100841001793 Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971 1100841001794 polyphosphate:AMP phosphotransferase; Region: poly_P_AMP_trns; TIGR03708 1100841001795 Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971 1100841001796 Uncharacterized protein/domain associated with GTPases [Function unknown]; Region: COG3597 1100841001797 Exodeoxyribonuclease V, gamma subunit; Region: Exonuc_V_gamma; pfam04257 1100841001798 exonuclease V subunit gamma; Provisional; Region: recC; PRK11069 1100841001799 Part of AAA domain; Region: AAA_19; pfam13245 1100841001800 ATP-dependent exoDNAse (exonuclease V) beta subunit (contains helicase and exonuclease domains) [DNA replication, recombination, and repair]; Region: RecB; COG1074 1100841001801 Family description; Region: UvrD_C_2; pfam13538 1100841001802 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 1100841001803 AAA domain; Region: AAA_22; pfam13401 1100841001804 AAA domain; Region: AAA_30; pfam13604 1100841001805 Family description; Region: UvrD_C_2; pfam13538 1100841001806 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1100841001807 Beta-lactamase; Region: Beta-lactamase; pfam00144 1100841001808 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 1100841001809 16S/18S rRNA binding site [nucleotide binding]; other site 1100841001810 S13e-L30e interaction site [polypeptide binding]; other site 1100841001811 25S rRNA binding site [nucleotide binding]; other site 1100841001812 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 1100841001813 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 1100841001814 RNase E interface [polypeptide binding]; other site 1100841001815 trimer interface [polypeptide binding]; other site 1100841001816 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 1100841001817 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 1100841001818 RNase E interface [polypeptide binding]; other site 1100841001819 trimer interface [polypeptide binding]; other site 1100841001820 active site 1100841001821 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 1100841001822 putative nucleic acid binding region [nucleotide binding]; other site 1100841001823 G-X-X-G motif; other site 1100841001824 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 1100841001825 RNA binding site [nucleotide binding]; other site 1100841001826 domain interface; other site 1100841001827 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 1100841001828 Thermotoga maritima CorA-like family; Region: TmCorA-like; cd12822 1100841001829 oligomer interface [polypeptide binding]; other site 1100841001830 metal binding site [ion binding]; metal-binding site 1100841001831 metal binding site [ion binding]; metal-binding site 1100841001832 putative Cl binding site [ion binding]; other site 1100841001833 aspartate ring; other site 1100841001834 basic sphincter; other site 1100841001835 hydrophobic gate; other site 1100841001836 periplasmic entrance; other site 1100841001837 MerR HTH family regulatory protein; Region: MerR_2; pfam13591 1100841001838 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1100841001839 chaperone protein DnaJ; Region: DnaJ_bact; TIGR02349 1100841001840 HSP70 interaction site [polypeptide binding]; other site 1100841001841 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 1100841001842 substrate binding site [polypeptide binding]; other site 1100841001843 dimer interface [polypeptide binding]; other site 1100841001844 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 1100841001845 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 1100841001846 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 1100841001847 dimerization interface [polypeptide binding]; other site 1100841001848 domain crossover interface; other site 1100841001849 redox-dependent activation switch; other site 1100841001850 glutathione-regulated potassium-efflux system protein KefC; Provisional; Region: PRK03562 1100841001851 transporter, monovalent cation:proton antiporter-2 (CPA2) family; Region: 2a37; TIGR00932 1100841001852 TrkA-N domain; Region: TrkA_N; pfam02254 1100841001853 primosome assembly protein PriA; Validated; Region: PRK05580 1100841001854 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1100841001855 ATP binding site [chemical binding]; other site 1100841001856 putative Mg++ binding site [ion binding]; other site 1100841001857 helicase superfamily c-terminal domain; Region: HELICc; smart00490 1100841001858 ATP-binding site [chemical binding]; other site 1100841001859 type II secretion system protein F; Region: GspF; TIGR02120 1100841001860 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1100841001861 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1100841001862 type II secretion system protein G; Region: typeII_sec_gspG; TIGR01710 1100841001863 Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334 1100841001864 tRNA-binding-domain-containing CsaA-like proteins. CsaA is a molecular chaperone with export related activities. CsaA has a putative tRNA binding activity. The functional unit of CsaA is a homodimer and this domain acts as a dimerization domain; Region: tRNA_bind_CsaA; cd02798 1100841001865 dimer interface [polypeptide binding]; other site 1100841001866 putative tRNA-binding site [nucleotide binding]; other site 1100841001867 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 1100841001868 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 1100841001869 putative active site [active] 1100841001870 catalytic triad [active] 1100841001871 putative dimer interface [polypeptide binding]; other site 1100841001872 FOG: CBS domain [General function prediction only]; Region: COG0517 1100841001873 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1100841001874 Transporter associated domain; Region: CorC_HlyC; smart01091 1100841001875 SirA (also known as UvrY, and YhhP) belongs to a family of two-component response regulators that controls secondary metabolism and virulence. The other member of this two-component system is a sensor kinase called BarA which phosphorylates SirA. A...; Region: SirA; cd03423 1100841001876 CPxP motif; other site 1100841001877 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 1100841001878 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1100841001879 Electron transfer flavoprotein-ubiquinone oxidoreductase; Region: ETF_QO; pfam05187 1100841001880 Ferredoxin-like protein [Energy production and conversion]; Region: FixX; COG2440 1100841001881 Protein of unknown function (DUF1285); Region: DUF1285; pfam06938 1100841001882 glutamate racemase; Provisional; Region: PRK00865 1100841001883 aspartate racemase; Region: asp_race; TIGR00035 1100841001884 Domain of unknown function (DUF4062); Region: DUF4062; pfam13271 1100841001885 ferrochelatase; Reviewed; Region: hemH; PRK00035 1100841001886 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 1100841001887 C-terminal domain interface [polypeptide binding]; other site 1100841001888 active site 1100841001889 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 1100841001890 active site 1100841001891 N-terminal domain interface [polypeptide binding]; other site 1100841001892 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 1100841001893 Domain of unknown function (DUF329); Region: DUF329; pfam03884 1100841001894 Putative methyltransferase; Region: Methyltransf_4; cl17290 1100841001895 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1100841001896 uncharacterized flavoprotein, PP_4765 family; Region: flavo_PP4765; TIGR03862 1100841001897 Glutathione-dependent formaldehyde-activating enzyme; Region: GFA; pfam04828 1100841001898 chromosome condensation membrane protein; Provisional; Region: PRK14196 1100841001899 HopJ type III effector protein; Region: HopJ; pfam08888 1100841001900 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 1100841001901 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 1100841001902 ABC1 family; Region: ABC1; pfam03109 1100841001903 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 1100841001904 Dibenzothiophene (DBT) desulfurization enzyme C; Region: DszC; cd01163 1100841001905 Flavin binding site [chemical binding]; other site 1100841001906 Dibenzothiophene (DBT) desulfurization enzyme C; Region: DszC; cd01163 1100841001907 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 1100841001908 Flavin binding site [chemical binding]; other site 1100841001909 multidrug efflux protein; Reviewed; Region: PRK01766 1100841001910 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 1100841001911 cation binding site [ion binding]; other site 1100841001912 Protein of unknown function, DUF606; Region: DUF606; pfam04657 1100841001913 HemN family oxidoreductase; Provisional; Region: PRK05660 1100841001914 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1100841001915 FeS/SAM binding site; other site 1100841001916 HemN C-terminal domain; Region: HemN_C; pfam06969 1100841001917 short chain dehydrogenase; Provisional; Region: PRK12744 1100841001918 tetrahydroxynaphthalene/trihydroxynaphthalene reductase-like, classical (c) SDRs; Region: THN_reductase-like_SDR_c; cd05362 1100841001919 NADP binding site [chemical binding]; other site 1100841001920 homodimer interface [polypeptide binding]; other site 1100841001921 active site 1100841001922 substrate binding site [chemical binding]; other site 1100841001923 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1100841001924 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1100841001925 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 1100841001926 putative effector binding pocket; other site 1100841001927 putative dimerization interface [polypeptide binding]; other site 1100841001928 long-chain-acyl-CoA synthetase; Validated; Region: PRK08279 1100841001929 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1100841001930 Fatty acid transport proteins (FATP) play dual roles as fatty acid transporters and its activation enzymes; Region: FATP_FACS; cd05940 1100841001931 acyl-activating enzyme (AAE) consensus motif; other site 1100841001932 putative AMP binding site [chemical binding]; other site 1100841001933 putative active site [active] 1100841001934 putative CoA binding site [chemical binding]; other site 1100841001935 Ribonucleases G and E [Translation, ribosomal structure and biogenesis]; Region: CafA; COG1530 1100841001936 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 1100841001937 homodimer interface [polypeptide binding]; other site 1100841001938 oligonucleotide binding site [chemical binding]; other site 1100841001939 23S rRNA pseudouridylate synthase C; Provisional; Region: PRK11025 1100841001940 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1100841001941 RNA binding surface [nucleotide binding]; other site 1100841001942 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1100841001943 active site 1100841001944 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 1100841001945 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1100841001946 motif II; other site 1100841001947 Predicted transcriptional regulator [Transcription]; Region: COG2378 1100841001948 HTH domain; Region: HTH_11; pfam08279 1100841001949 WYL domain; Region: WYL; pfam13280 1100841001950 GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972 1100841001951 GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046 1100841001952 putative C-terminal domain interface [polypeptide binding]; other site 1100841001953 putative GSH binding site (G-site) [chemical binding]; other site 1100841001954 putative dimer interface [polypeptide binding]; other site 1100841001955 C-terminal, alpha helical domain of an unknown subfamily 8 of Glutathione S-transferases; Region: GST_C_8; cd03207 1100841001956 dimer interface [polypeptide binding]; other site 1100841001957 N-terminal domain interface [polypeptide binding]; other site 1100841001958 putative substrate binding pocket (H-site) [chemical binding]; other site 1100841001959 Protein of unknown function (DUF1345); Region: DUF1345; pfam07077 1100841001960 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 1100841001961 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1100841001962 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1100841001963 dimerization interface [polypeptide binding]; other site 1100841001964 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 1100841001965 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 1100841001966 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 1100841001967 Heme-dependent peroxidases similar to plant peroxidases; Region: plant_peroxidase_like; cl00196 1100841001968 heme binding site [chemical binding]; other site 1100841001969 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 1100841001970 Signal transduction protein containing GAF and PtsI domains [Signal transduction mechanisms]; Region: PtsP; COG3605 1100841001971 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1100841001972 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 1100841001973 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1100841001974 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 1100841001975 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671 1100841001976 putative active site [active] 1100841001977 Ap4A binding site [chemical binding]; other site 1100841001978 nudix motif; other site 1100841001979 putative metal binding site [ion binding]; other site 1100841001980 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 1100841001981 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1100841001982 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1100841001983 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1100841001984 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1100841001985 dimerization interface [polypeptide binding]; other site 1100841001986 Predicted membrane protein (DUF2061); Region: DUF2061; pfam09834 1100841001987 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 1100841001988 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 1100841001989 substrate binding site [chemical binding]; other site 1100841001990 ligand binding site [chemical binding]; other site 1100841001991 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 1100841001992 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 1100841001993 substrate binding site [chemical binding]; other site 1100841001994 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 1100841001995 tartrate dehydrogenase; Region: TTC; TIGR02089 1100841001996 Protein of unknown function (DUF1311); Region: DUF1311; cl01530 1100841001997 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 1100841001998 rRNA binding site [nucleotide binding]; other site 1100841001999 predicted 30S ribosome binding site; other site 1100841002000 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 1100841002001 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 1100841002002 dimerization interface 3.5A [polypeptide binding]; other site 1100841002003 active site 1100841002004 Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963 1100841002005 active site 1100841002006 homodimer interface [polypeptide binding]; other site 1100841002007 FimV N-terminal domain; Region: FimV_core; TIGR03505 1100841002008 aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK06598 1100841002009 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1100841002010 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 1100841002011 putative catalytic site [active] 1100841002012 putative metal binding site [ion binding]; other site 1100841002013 putative phosphate binding site [ion binding]; other site 1100841002014 glutamate/aspartate:proton symporter; Provisional; Region: gltP; PRK11283 1100841002015 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1100841002016 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1100841002017 This family is most closely related to the GT1 family of glycosyltransferases. WavL in Vibrio cholerae has been shown to be involved in the biosynthesis of the lipopolysaccharide core; Region: GT1_WavL_like; cd03819 1100841002018 putative ADP-binding pocket [chemical binding]; other site 1100841002019 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 1100841002020 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 1100841002021 putative acyl-acceptor binding pocket; other site 1100841002022 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 1100841002023 ABC transporter ATPase component; Reviewed; Region: PRK11147 1100841002024 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1100841002025 Walker A/P-loop; other site 1100841002026 ATP binding site [chemical binding]; other site 1100841002027 Q-loop/lid; other site 1100841002028 ABC transporter signature motif; other site 1100841002029 Walker B; other site 1100841002030 D-loop; other site 1100841002031 H-loop/switch region; other site 1100841002032 ABC transporter; Region: ABC_tran_2; pfam12848 1100841002033 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1100841002034 SlyX; Region: SlyX; pfam04102 1100841002035 Arginate lyase and other MDR family members; Region: AL_MDR; cd08252 1100841002036 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817 1100841002037 putative NAD(P) binding site [chemical binding]; other site 1100841002038 dimer interface [polypeptide binding]; other site 1100841002039 Predicted transcriptional regulators [Transcription]; Region: COG1733 1100841002040 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1100841002041 Ammonium Transporter Family; Region: Ammonium_transp; cl03012 1100841002042 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 1100841002043 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 1100841002044 active site 1100841002045 interdomain interaction site; other site 1100841002046 putative metal-binding site [ion binding]; other site 1100841002047 nucleotide binding site [chemical binding]; other site 1100841002048 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 1100841002049 domain I; other site 1100841002050 DNA binding groove [nucleotide binding] 1100841002051 phosphate binding site [ion binding]; other site 1100841002052 domain II; other site 1100841002053 domain III; other site 1100841002054 nucleotide binding site [chemical binding]; other site 1100841002055 catalytic site [active] 1100841002056 domain IV; other site 1100841002057 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1100841002058 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1100841002059 Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272 1100841002060 Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272 1100841002061 Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247 1100841002062 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 1100841002063 Part of AAA domain; Region: AAA_19; pfam13245 1100841002064 Family description; Region: UvrD_C_2; pfam13538 1100841002065 RNA-binding proteins (RRM domain) [General function prediction only]; Region: COG0724 1100841002066 RNA recognition motif; Region: RRM; smart00360 1100841002067 ASC-1 homology or ASCH domain, a small beta-barrel domain found in all three kingdoms of life. ASCH resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as an RNA-binding domain during coactivation; Region: ASCH; cl01020 1100841002068 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 1100841002069 TrkA-N domain; Region: TrkA_N; pfam02254 1100841002070 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 1100841002071 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 1100841002072 aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381 1100841002073 Coniferyl aldehyde dehydrogenase-like; Region: ALDH_CALDH_CalB; cd07133 1100841002074 NAD(P) binding site [chemical binding]; other site 1100841002075 catalytic residues [active] 1100841002076 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1100841002077 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1100841002078 Bacterial transcriptional repressor; Region: TetR; pfam13972 1100841002079 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 1100841002080 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 1100841002081 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 1100841002082 putative active site [active] 1100841002083 putative substrate binding site [chemical binding]; other site 1100841002084 putative cosubstrate binding site; other site 1100841002085 catalytic site [active] 1100841002086 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 1100841002087 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 1100841002088 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 1100841002089 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 1100841002090 methionine sulfoxide reductase A; Provisional; Region: PRK14054 1100841002091 Domain of unknown function (DUF4105); Region: DUF4105; pfam13387 1100841002092 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 1100841002093 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 1100841002094 folate binding site [chemical binding]; other site 1100841002095 NADP+ binding site [chemical binding]; other site 1100841002096 thymidylate synthase; Reviewed; Region: thyA; PRK01827 1100841002097 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 1100841002098 dimerization interface [polypeptide binding]; other site 1100841002099 active site 1100841002100 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK12437 1100841002101 NRDE protein; Region: NRDE; cl01315 1100841002102 Predicted phosphatase [General function prediction only]; Region: PhoX; COG3211 1100841002103 Bacterial protein of unknown function (DUF839); Region: DUF839; pfam05787 1100841002104 Sec-independent protein translocase protein (TatC); Region: TatC; cl00521 1100841002105 twin arginine-targeting protein translocase TatB; Region: tatB; TIGR01410 1100841002106 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 1100841002107 Membrane transport protein; Region: Mem_trans; cl09117 1100841002108 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 1100841002109 active site 1100841002110 dimerization interface [polypeptide binding]; other site 1100841002111 Sel1-like repeats; Region: SEL1; smart00671 1100841002112 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 1100841002113 Sel1-like repeats; Region: SEL1; smart00671 1100841002114 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1100841002115 S-adenosylmethionine binding site [chemical binding]; other site 1100841002116 homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175 1100841002117 homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392 1100841002118 2-isopropylmalate synthase; Validated; Region: PRK03739 1100841002119 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 1100841002120 active site 1100841002121 catalytic residues [active] 1100841002122 metal binding site [ion binding]; metal-binding site 1100841002123 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 1100841002124 Fe(II)-dependent oxygenase superfamily protein; Provisional; Region: PRK05467 1100841002125 Outer membrane receptor for monomeric catechols [Inorganic ion transport and metabolism]; Region: Fiu; COG4774 1100841002126 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1100841002127 N-terminal plug; other site 1100841002128 ligand-binding site [chemical binding]; other site 1100841002129 trigger factor; Provisional; Region: tig; PRK01490 1100841002130 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1100841002131 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 1100841002132 Clp protease; Region: CLP_protease; pfam00574 1100841002133 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 1100841002134 oligomer interface [polypeptide binding]; other site 1100841002135 active site residues [active] 1100841002136 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 1100841002137 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 1100841002138 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1100841002139 Walker A motif; other site 1100841002140 ATP binding site [chemical binding]; other site 1100841002141 Walker B motif; other site 1100841002142 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1100841002143 Protein of unknown function (DUF2846); Region: DUF2846; pfam11008 1100841002144 Uncharacterized protein conserved in bacteria (DUF2059); Region: DUF2059; pfam09832 1100841002145 Fumarate hydratase (Fumerase); Region: Fumerase; pfam05681 1100841002146 Fumarase C-terminus; Region: Fumerase_C; pfam05683 1100841002147 phosphate acetyltransferase; Reviewed; Region: PRK05632 1100841002148 DRTGG domain; Region: DRTGG; pfam07085 1100841002149 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 1100841002150 propionate/acetate kinase; Provisional; Region: PRK12379 1100841002151 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1100841002152 nucleotide binding site [chemical binding]; other site 1100841002153 Butyrate kinase [Energy production and conversion]; Region: COG3426 1100841002154 phosphogluconate dehydratase; Validated; Region: PRK09054 1100841002155 6-phosphogluconate dehydratase; Region: edd; TIGR01196 1100841002156 keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718 1100841002157 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 1100841002158 active site 1100841002159 intersubunit interface [polypeptide binding]; other site 1100841002160 catalytic residue [active] 1100841002161 GntP family permease; Region: GntP_permease; pfam02447 1100841002162 fructuronate transporter; Provisional; Region: PRK10034; cl15264 1100841002163 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 1100841002164 ATP-binding site [chemical binding]; other site 1100841002165 Gluconate-6-phosphate binding site [chemical binding]; other site 1100841002166 Shikimate kinase; Region: SKI; pfam01202 1100841002167 NADP+-dependent non-phosphorylating glyceraldehyde 3-phosphate dehydrogenase and ALDH family 11; Region: ALDH_F11_NP-GAPDH; cd07082 1100841002168 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 1100841002169 tetrameric interface [polypeptide binding]; other site 1100841002170 activator binding site; other site 1100841002171 NADP binding site [chemical binding]; other site 1100841002172 substrate binding site [chemical binding]; other site 1100841002173 catalytic residues [active] 1100841002174 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 1100841002175 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 1100841002176 putative catalytic cysteine [active] 1100841002177 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1100841002178 Leucine carboxyl methyltransferase; Region: LCM; pfam04072 1100841002179 beta-hexosaminidase; Provisional; Region: PRK05337 1100841002180 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 1100841002181 carboxy-terminal protease; Provisional; Region: PRK11186 1100841002182 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 1100841002183 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 1100841002184 protein binding site [polypeptide binding]; other site 1100841002185 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 1100841002186 Catalytic dyad [active] 1100841002187 C-terminal domain of tail specific protease (DUF3340); Region: DUF3340; pfam11818 1100841002188 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1100841002189 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 1100841002190 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 1100841002191 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 1100841002192 active site 1100841002193 Iron-sulphur cluster assembly; Region: Fe-S_assembly; pfam04384 1100841002194 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 1100841002195 active site 1100841002196 multimer interface [polypeptide binding]; other site 1100841002197 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK11194 1100841002198 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1100841002199 FeS/SAM binding site; other site 1100841002200 type IV pilus biogenesis/stability protein PilW; Region: type_IV_pilW; TIGR02521 1100841002201 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1100841002202 TPR motif; other site 1100841002203 binding surface 1100841002204 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1100841002205 TPR motif; other site 1100841002206 binding surface 1100841002207 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1100841002208 binding surface 1100841002209 TPR motif; other site 1100841002210 Helix-turn-helix domain; Region: HTH_25; pfam13413 1100841002211 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 1100841002212 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 1100841002213 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 1100841002214 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 1100841002215 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 1100841002216 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 1100841002217 dimer interface [polypeptide binding]; other site 1100841002218 motif 1; other site 1100841002219 active site 1100841002220 motif 2; other site 1100841002221 motif 3; other site 1100841002222 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 1100841002223 anticodon binding site; other site 1100841002224 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2976 1100841002225 Uncharacterized protein conserved in bacteria (DUF2133); Region: DUF2133; pfam09976 1100841002226 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1100841002227 TPR motif; other site 1100841002228 binding surface 1100841002229 outer membrane assembly lipoprotein YfgL; Region: assembly_YfgL; TIGR03300 1100841002230 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 1100841002231 Trp docking motif [polypeptide binding]; other site 1100841002232 active site 1100841002233 GTP-binding protein Der; Reviewed; Region: PRK00093 1100841002234 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 1100841002235 G1 box; other site 1100841002236 GTP/Mg2+ binding site [chemical binding]; other site 1100841002237 Switch I region; other site 1100841002238 G2 box; other site 1100841002239 Switch II region; other site 1100841002240 G3 box; other site 1100841002241 G4 box; other site 1100841002242 G5 box; other site 1100841002243 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 1100841002244 G1 box; other site 1100841002245 GTP/Mg2+ binding site [chemical binding]; other site 1100841002246 Switch I region; other site 1100841002247 G2 box; other site 1100841002248 G3 box; other site 1100841002249 Switch II region; other site 1100841002250 G4 box; other site 1100841002251 G5 box; other site 1100841002252 Beta-ketoacyl synthase, N-terminal domain; Region: Ketoacyl-synt_2; pfam13723 1100841002253 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1100841002254 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1100841002255 putative acyl-acceptor binding pocket; other site 1100841002256 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1100841002257 acyl carrier protein; Provisional; Region: PRK05350 1100841002258 Predicted membrane protein [Function unknown]; Region: COG4648 1100841002259 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1100841002260 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 1100841002261 acyl-activating enzyme (AAE) consensus motif; other site 1100841002262 active site 1100841002263 AMP binding site [chemical binding]; other site 1100841002264 CoA binding site [chemical binding]; other site 1100841002265 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1100841002266 active site 2 [active] 1100841002267 active site 1 [active] 1100841002268 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 1100841002269 Ligand binding site; other site 1100841002270 Putative Catalytic site; other site 1100841002271 DXD motif; other site 1100841002272 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 1100841002273 putative acyl-acceptor binding pocket; other site 1100841002274 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 1100841002275 active sites [active] 1100841002276 tetramer interface [polypeptide binding]; other site 1100841002277 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1100841002278 active site 1100841002279 Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl17548 1100841002280 Predicted exporter [General function prediction only]; Region: COG4258 1100841002281 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 1100841002282 3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK09185 1100841002283 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1100841002284 dimer interface [polypeptide binding]; other site 1100841002285 active site 1100841002286 Domain of unknown function, appears to be related to a diverse group of beta-hydroxydecanoyl ACP dehydratases (FabA) and beta-hydroxyacyl ACP dehydratases (FabZ). This group appears to lack the conserved active site histidine of FabA and FabZ; Region: FabA_like; cd01289 1100841002287 putative active site 1 [active] 1100841002288 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1100841002289 NAD(P) binding site [chemical binding]; other site 1100841002290 active site 1100841002291 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK09116 1100841002292 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1100841002293 dimer interface [polypeptide binding]; other site 1100841002294 active site 1100841002295 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 1100841002296 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 1100841002297 preprotein translocase subunit SecB; Validated; Region: PRK05751 1100841002298 SecA binding site; other site 1100841002299 Preprotein binding site; other site 1100841002300 Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418 1100841002301 GSH binding site [chemical binding]; other site 1100841002302 catalytic residues [active] 1100841002303 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1100841002304 active site residue [active] 1100841002305 GTPase RsgA; Reviewed; Region: PRK12288 1100841002306 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1100841002307 RNA binding site [nucleotide binding]; other site 1100841002308 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 1100841002309 GTPase/Zn-binding domain interface [polypeptide binding]; other site 1100841002310 GTP/Mg2+ binding site [chemical binding]; other site 1100841002311 G4 box; other site 1100841002312 G5 box; other site 1100841002313 G1 box; other site 1100841002314 Switch I region; other site 1100841002315 G2 box; other site 1100841002316 G3 box; other site 1100841002317 Switch II region; other site 1100841002318 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 1100841002319 catalytic site [active] 1100841002320 putative active site [active] 1100841002321 putative substrate binding site [chemical binding]; other site 1100841002322 dimer interface [polypeptide binding]; other site 1100841002323 Bax inhibitor 1 like; Region: BaxI_1; cl17691 1100841002324 Enoyl-[acyl-carrier-protein]; Region: FabI; COG0623 1100841002325 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 1100841002326 NAD binding site [chemical binding]; other site 1100841002327 homotetramer interface [polypeptide binding]; other site 1100841002328 homodimer interface [polypeptide binding]; other site 1100841002329 substrate binding site [chemical binding]; other site 1100841002330 active site 1100841002331 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 1100841002332 macrolide transporter ATP-binding /permease protein; Provisional; Region: PRK10535 1100841002333 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1100841002334 Walker A/P-loop; other site 1100841002335 ATP binding site [chemical binding]; other site 1100841002336 Q-loop/lid; other site 1100841002337 ABC transporter signature motif; other site 1100841002338 Walker B; other site 1100841002339 D-loop; other site 1100841002340 H-loop/switch region; other site 1100841002341 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1100841002342 FtsX-like permease family; Region: FtsX; pfam02687 1100841002343 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1100841002344 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1100841002345 HlyD family secretion protein; Region: HlyD_3; pfam13437 1100841002346 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 1100841002347 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 1100841002348 Lipopolysaccharide-assembly; Region: LptE; pfam04390 1100841002349 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 1100841002350 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 1100841002351 HIGH motif; other site 1100841002352 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1100841002353 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1100841002354 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1100841002355 active site 1100841002356 KMSKS motif; other site 1100841002357 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 1100841002358 tRNA binding surface [nucleotide binding]; other site 1100841002359 Domain of unknown function (DUF4124); Region: DUF4124; pfam13511 1100841002360 acetolactate synthase 3 catalytic subunit; Validated; Region: PRK06466 1100841002361 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1100841002362 PYR/PP interface [polypeptide binding]; other site 1100841002363 dimer interface [polypeptide binding]; other site 1100841002364 TPP binding site [chemical binding]; other site 1100841002365 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1100841002366 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 1100841002367 TPP-binding site [chemical binding]; other site 1100841002368 dimer interface [polypeptide binding]; other site 1100841002369 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 1100841002370 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 1100841002371 putative valine binding site [chemical binding]; other site 1100841002372 dimer interface [polypeptide binding]; other site 1100841002373 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 1100841002374 ketol-acid reductoisomerase; Provisional; Region: PRK05479 1100841002375 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 1100841002376 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 1100841002377 MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300 1100841002378 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1100841002379 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1100841002380 metal binding site [ion binding]; metal-binding site 1100841002381 active site 1100841002382 I-site; other site 1100841002383 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1100841002384 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1100841002385 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1100841002386 transcriptional repressor BetI; Region: betaine_BetI; TIGR03384 1100841002387 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1100841002388 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 1100841002389 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 1100841002390 G1 box; other site 1100841002391 putative GEF interaction site [polypeptide binding]; other site 1100841002392 GTP/Mg2+ binding site [chemical binding]; other site 1100841002393 Switch I region; other site 1100841002394 G2 box; other site 1100841002395 G3 box; other site 1100841002396 Switch II region; other site 1100841002397 G4 box; other site 1100841002398 G5 box; other site 1100841002399 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 1100841002400 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 1100841002401 Domain of unknown function (DUF4163); Region: DUF4163; pfam13739 1100841002402 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 1100841002403 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 1100841002404 active site 1100841002405 aconitate hydratase; Validated; Region: PRK09277 1100841002406 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 1100841002407 substrate binding site [chemical binding]; other site 1100841002408 ligand binding site [chemical binding]; other site 1100841002409 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 1100841002410 substrate binding site [chemical binding]; other site 1100841002411 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 1100841002412 homotrimer interaction site [polypeptide binding]; other site 1100841002413 putative active site [active] 1100841002414 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179 1100841002415 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 1100841002416 putative ATP binding site [chemical binding]; other site 1100841002417 putative substrate interface [chemical binding]; other site 1100841002418 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1100841002419 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1100841002420 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 1100841002421 dimerization interface [polypeptide binding]; other site 1100841002422 substrate binding pocket [chemical binding]; other site 1100841002423 tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815 1100841002424 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 1100841002425 FMN binding site [chemical binding]; other site 1100841002426 active site 1100841002427 catalytic residues [active] 1100841002428 substrate binding site [chemical binding]; other site 1100841002429 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1100841002430 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1100841002431 putative substrate translocation pore; other site 1100841002432 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 1100841002433 homotrimer interaction site [polypeptide binding]; other site 1100841002434 putative active site [active] 1100841002435 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1100841002436 EamA-like transporter family; Region: EamA; pfam00892 1100841002437 EamA-like transporter family; Region: EamA; pfam00892 1100841002438 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 1100841002439 NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288 1100841002440 ligand binding site [chemical binding]; other site 1100841002441 homodimer interface [polypeptide binding]; other site 1100841002442 NAD(P) binding site [chemical binding]; other site 1100841002443 trimer interface B [polypeptide binding]; other site 1100841002444 trimer interface A [polypeptide binding]; other site 1100841002445 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 1100841002446 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 1100841002447 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; COG1282 1100841002448 iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090 1100841002449 hydroxypyruvate isomerase; Region: OH-pyruv-isom; TIGR03234 1100841002450 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 1100841002451 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1100841002452 enoyl-CoA hydratase; Provisional; Region: PRK07509 1100841002453 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1100841002454 substrate binding site [chemical binding]; other site 1100841002455 oxyanion hole (OAH) forming residues; other site 1100841002456 trimer interface [polypeptide binding]; other site 1100841002457 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1100841002458 dimer interface [polypeptide binding]; other site 1100841002459 phosphorylation site [posttranslational modification] 1100841002460 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1100841002461 ATP binding site [chemical binding]; other site 1100841002462 Mg2+ binding site [ion binding]; other site 1100841002463 G-X-G motif; other site 1100841002464 Response regulator receiver domain; Region: Response_reg; pfam00072 1100841002465 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1100841002466 active site 1100841002467 phosphorylation site [posttranslational modification] 1100841002468 intermolecular recognition site; other site 1100841002469 dimerization interface [polypeptide binding]; other site 1100841002470 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086 1100841002471 cysteine synthase B; Region: cysM; TIGR01138 1100841002472 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1100841002473 dimer interface [polypeptide binding]; other site 1100841002474 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1100841002475 catalytic residue [active] 1100841002476 Uncharacterized bacterial subgroup of the DEDDy 3'-5' exonuclease domain of family-B DNA polymerases; Region: DNA_polB_like1_exo; cd05782 1100841002477 active site 1100841002478 catalytic site [active] 1100841002479 substrate binding site [chemical binding]; other site 1100841002480 Predicted 3'-5' exonuclease related to the exonuclease domain of PolB; Region: DNA_pol_B_exo2; pfam10108 1100841002481 23S rRNA m(5)U1939 methyltransferase; Reviewed; Region: rumA; PRK13168 1100841002482 TRAM domain; Region: TRAM; pfam01938 1100841002483 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1100841002484 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1100841002485 S-adenosylmethionine binding site [chemical binding]; other site 1100841002486 HD domain; Region: HD_4; pfam13328 1100841002487 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 1100841002488 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1100841002489 synthetase active site [active] 1100841002490 NTP binding site [chemical binding]; other site 1100841002491 metal binding site [ion binding]; metal-binding site 1100841002492 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 1100841002493 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 1100841002494 short chain dehydrogenase; Provisional; Region: PRK08267 1100841002495 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1100841002496 NAD(P) binding site [chemical binding]; other site 1100841002497 active site 1100841002498 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 1100841002499 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 1100841002500 homodimer interface [polypeptide binding]; other site 1100841002501 metal binding site [ion binding]; metal-binding site 1100841002502 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 1100841002503 homodimer interface [polypeptide binding]; other site 1100841002504 active site 1100841002505 putative chemical substrate binding site [chemical binding]; other site 1100841002506 metal binding site [ion binding]; metal-binding site 1100841002507 DNA uptake protein and related DNA-binding proteins [DNA replication, recombination, and repair]; Region: ComEA; COG1555 1100841002508 Helix-hairpin-helix motif; Region: HHH; pfam00633 1100841002509 poly(A) polymerase; Region: pcnB; TIGR01942 1100841002510 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 1100841002511 active site 1100841002512 NTP binding site [chemical binding]; other site 1100841002513 metal binding triad [ion binding]; metal-binding site 1100841002514 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 1100841002515 Polymerase A arginine-rich C-terminus; Region: PolyA_pol_arg_C; pfam12626 1100841002516 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 1100841002517 catalytic center binding site [active] 1100841002518 ATP binding site [chemical binding]; other site 1100841002519 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 1100841002520 oligomerization interface [polypeptide binding]; other site 1100841002521 active site 1100841002522 metal binding site [ion binding]; metal-binding site 1100841002523 pantoate--beta-alanine ligase; Region: panC; TIGR00018 1100841002524 Pantoate-beta-alanine ligase; Region: PanC; cd00560 1100841002525 active site 1100841002526 ATP-binding site [chemical binding]; other site 1100841002527 pantoate-binding site; other site 1100841002528 HXXH motif; other site 1100841002529 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 1100841002530 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 1100841002531 dimerization domain swap beta strand [polypeptide binding]; other site 1100841002532 regulatory protein interface [polypeptide binding]; other site 1100841002533 active site 1100841002534 regulatory phosphorylation site [posttranslational modification]; other site 1100841002535 hypothetical protein; Provisional; Region: PRK05255 1100841002536 acyl-CoA synthetase; Validated; Region: PRK08162 1100841002537 Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles and Arabidopsis; Region: ttLC_FACS_AEE21_like; cd12118 1100841002538 acyl-activating enzyme (AAE) consensus motif; other site 1100841002539 putative active site [active] 1100841002540 AMP binding site [chemical binding]; other site 1100841002541 putative CoA binding site [chemical binding]; other site 1100841002542 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 1100841002543 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 1100841002544 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 1100841002545 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 1100841002546 active site 1100841002547 dimer interface [polypeptide binding]; other site 1100841002548 motif 1; other site 1100841002549 motif 2; other site 1100841002550 motif 3; other site 1100841002551 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 1100841002552 anticodon binding site; other site 1100841002553 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 1100841002554 GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972 1100841002555 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 1100841002556 C-terminal domain interface [polypeptide binding]; other site 1100841002557 GSH binding site (G-site) [chemical binding]; other site 1100841002558 dimer interface [polypeptide binding]; other site 1100841002559 C-terminal, alpha helical domain of Escherichia coli YfcG Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YfcG_like; cd10291 1100841002560 N-terminal domain interface [polypeptide binding]; other site 1100841002561 putative dimer interface [polypeptide binding]; other site 1100841002562 active site 1100841002563 Predicted membrane protein [Function unknown]; Region: COG1238 1100841002564 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1100841002565 putative substrate translocation pore; other site 1100841002566 H+ Antiporter protein; Region: 2A0121; TIGR00900 1100841002567 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 1100841002568 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 1100841002569 23S rRNA binding site [nucleotide binding]; other site 1100841002570 L21 binding site [polypeptide binding]; other site 1100841002571 L13 binding site [polypeptide binding]; other site 1100841002572 Domain of unknown function (DUF1768); Region: DUF1768; pfam08719 1100841002573 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1100841002574 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1100841002575 Coenzyme A binding pocket [chemical binding]; other site 1100841002576 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 1100841002577 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 1100841002578 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 1100841002579 dimer interface [polypeptide binding]; other site 1100841002580 motif 1; other site 1100841002581 active site 1100841002582 motif 2; other site 1100841002583 motif 3; other site 1100841002584 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 1100841002585 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 1100841002586 putative tRNA-binding site [nucleotide binding]; other site 1100841002587 B3/4 domain; Region: B3_4; pfam03483 1100841002588 tRNA synthetase B5 domain; Region: B5; smart00874 1100841002589 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 1100841002590 dimer interface [polypeptide binding]; other site 1100841002591 motif 1; other site 1100841002592 motif 3; other site 1100841002593 motif 2; other site 1100841002594 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 1100841002595 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1100841002596 IHF dimer interface [polypeptide binding]; other site 1100841002597 IHF - DNA interface [nucleotide binding]; other site 1100841002598 transcription termination factor Rho; Provisional; Region: rho; PRK09376 1100841002599 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 1100841002600 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 1100841002601 RNA binding site [nucleotide binding]; other site 1100841002602 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 1100841002603 multimer interface [polypeptide binding]; other site 1100841002604 Walker A motif; other site 1100841002605 ATP binding site [chemical binding]; other site 1100841002606 Walker B motif; other site 1100841002607 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1100841002608 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1100841002609 catalytic residues [active] 1100841002610 guanosine pentaphosphate phosphohydrolase; Provisional; Region: PRK11031 1100841002611 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 1100841002612 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 1100841002613 tRNA(Ile)-lysidine synthetase; Provisional; Region: tilS; PRK10660 1100841002614 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 1100841002615 TilS substrate binding domain; Region: TilS; pfam09179 1100841002616 TilS substrate C-terminal domain; Region: TilS_C; pfam11734 1100841002617 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 1100841002618 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 1100841002619 YGGT family; Region: YGGT; pfam02325 1100841002620 DNA polymerase I; Provisional; Region: PRK05755 1100841002621 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 1100841002622 active site 1100841002623 metal binding site 1 [ion binding]; metal-binding site 1100841002624 putative 5' ssDNA interaction site; other site 1100841002625 metal binding site 3; metal-binding site 1100841002626 metal binding site 2 [ion binding]; metal-binding site 1100841002627 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 1100841002628 putative DNA binding site [nucleotide binding]; other site 1100841002629 putative metal binding site [ion binding]; other site 1100841002630 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 1100841002631 active site 1100841002632 catalytic site [active] 1100841002633 substrate binding site [chemical binding]; other site 1100841002634 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 1100841002635 active site 1100841002636 DNA binding site [nucleotide binding] 1100841002637 catalytic site [active] 1100841002638 Predicted membrane protein (DUF2339); Region: DUF2339; pfam10101 1100841002639 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1100841002640 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1100841002641 Protein of unknown function (DUF432); Region: DUF432; cl01027 1100841002642 type II secretion system protein E; Region: type_II_gspE; TIGR02533 1100841002643 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 1100841002644 Walker A motif; other site 1100841002645 ATP binding site [chemical binding]; other site 1100841002646 Walker B motif; other site 1100841002647 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 1100841002648 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1100841002649 MarR family; Region: MarR; pfam01047 1100841002650 Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases); Region: nit; cd07572 1100841002651 nitrilase; Region: PLN02798 1100841002652 putative active site [active] 1100841002653 catalytic triad [active] 1100841002654 dimer interface [polypeptide binding]; other site 1100841002655 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1100841002656 anti sigma factor interaction site; other site 1100841002657 regulatory phosphorylation site [posttranslational modification]; other site 1100841002658 Sigma factor PP2C-like phosphatases; Region: PP2C_SIG; smart00331 1100841002659 VacJ like lipoprotein; Region: VacJ; cl01073 1100841002660 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 1100841002661 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 1100841002662 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 1100841002663 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 1100841002664 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 1100841002665 30S subunit binding site; other site 1100841002666 BolA-like protein; Region: BolA; cl00386 1100841002667 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 1100841002668 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 1100841002669 hinge; other site 1100841002670 active site 1100841002671 ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040 1100841002672 ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686 1100841002673 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 1100841002674 histidinol dehydrogenase; Region: hisD; TIGR00069 1100841002675 NAD binding site [chemical binding]; other site 1100841002676 dimerization interface [polypeptide binding]; other site 1100841002677 product binding site; other site 1100841002678 substrate binding site [chemical binding]; other site 1100841002679 zinc binding site [ion binding]; other site 1100841002680 catalytic residues [active] 1100841002681 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 1100841002682 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1100841002683 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1100841002684 homodimer interface [polypeptide binding]; other site 1100841002685 catalytic residue [active] 1100841002686 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 1100841002687 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 1100841002688 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 1100841002689 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39G; cd02423 1100841002690 putative active site [active] 1100841002691 Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; cl17479 1100841002692 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 1100841002693 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_4; cd04511 1100841002694 nudix motif; other site 1100841002695 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 1100841002696 putative active site [active] 1100841002697 putative CoA binding site [chemical binding]; other site 1100841002698 nudix motif; other site 1100841002699 metal binding site [ion binding]; metal-binding site 1100841002700 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 1100841002701 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 1100841002702 trimer interface [polypeptide binding]; other site 1100841002703 putative metal binding site [ion binding]; other site 1100841002704 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 1100841002705 Glycoprotease family; Region: Peptidase_M22; pfam00814 1100841002706 Putative SAM-dependent methyltransferase; Region: SAM_MT; cl17517 1100841002707 Peptidase C13 family; Region: Peptidase_C13; pfam01650 1100841002708 S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821 1100841002709 S-formylglutathione hydrolase; Region: PLN02442 1100841002710 Uncharacterized protein conserved in bacteria (DUF2218); Region: DUF2218; pfam09981 1100841002711 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 1100841002712 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 1100841002713 substrate binding site [chemical binding]; other site 1100841002714 hexamer interface [polypeptide binding]; other site 1100841002715 metal binding site [ion binding]; metal-binding site 1100841002716 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1100841002717 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1100841002718 active site 1100841002719 motif I; other site 1100841002720 motif II; other site 1100841002721 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1100841002722 copper-resistance protein, CopA family; Region: copper_res_A; TIGR01480 1100841002723 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 1100841002724 Multicopper oxidase; Region: Cu-oxidase; pfam00394 1100841002725 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 1100841002726 Copper resistance protein B precursor (CopB); Region: CopB; pfam05275 1100841002727 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 1100841002728 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 1100841002729 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 1100841002730 methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901 1100841002731 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1100841002732 DNA binding site [nucleotide binding] 1100841002733 active site 1100841002734 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 1100841002735 heterotetramer interface [polypeptide binding]; other site 1100841002736 active site pocket [active] 1100841002737 cleavage site 1100841002738 quinolinate synthetase; Provisional; Region: PRK09375 1100841002739 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 1100841002740 Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320 1100841002741 active site 1100841002742 purine riboside binding site [chemical binding]; other site 1100841002743 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1100841002744 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH8; cd08262 1100841002745 putative NAD(P) binding site [chemical binding]; other site 1100841002746 catalytic Zn binding site [ion binding]; other site 1100841002747 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 1100841002748 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1100841002749 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1100841002750 dimerization interface [polypeptide binding]; other site 1100841002751 Glutaryl-CoA dehydrogenase; Region: GCD; cd01151 1100841002752 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1100841002753 FAD binding site [chemical binding]; other site 1100841002754 substrate binding pocket [chemical binding]; other site 1100841002755 catalytic base [active] 1100841002756 benzoate transport; Region: 2A0115; TIGR00895 1100841002757 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1100841002758 putative substrate translocation pore; other site 1100841002759 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1100841002760 nitrobindin heme-binding domain; Region: nitrobindin; cl10502 1100841002761 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1100841002762 tricarballylate utilization protein B; Provisional; Region: PRK15033 1100841002763 tricarballylate dehydrogenase; Validated; Region: PRK08274 1100841002764 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 1100841002765 The C-teminal substrate binding domain of LysR-like nitrogen assimilation control (NAC) protein, contains the type 2 periplasmic binding fold; Region: PBP2_Nac; cd08433 1100841002766 putative dimerization interface [polypeptide binding]; other site 1100841002767 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 1100841002768 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1100841002769 citrate-proton symporter; Provisional; Region: PRK15075 1100841002770 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1100841002771 putative substrate translocation pore; other site 1100841002772 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1100841002773 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1100841002774 The C-teminal substrate binding domain of LysR-like nitrogen assimilation control (NAC) protein, contains the type 2 periplasmic binding fold; Region: PBP2_Nac; cd08433 1100841002775 putative dimerization interface [polypeptide binding]; other site 1100841002776 Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; cl17479 1100841002777 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1100841002778 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like6; cd05664 1100841002779 metal binding site [ion binding]; metal-binding site 1100841002780 putative dimer interface [polypeptide binding]; other site 1100841002781 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 1100841002782 SurA N-terminal domain; Region: SurA_N; pfam09312 1100841002783 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1100841002784 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1100841002785 Fatty acid desaturase; Region: FA_desaturase; pfam00487 1100841002786 LysE type translocator; Region: LysE; cl00565 1100841002787 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 1100841002788 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1100841002789 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1100841002790 dimerization interface [polypeptide binding]; other site 1100841002791 Domain of unknown function (DUF1852); Region: DUF1852; pfam08908 1100841002792 methionine synthase; Provisional; Region: PRK01207 1100841002793 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 1100841002794 substrate binding site [chemical binding]; other site 1100841002795 THF binding site; other site 1100841002796 zinc-binding site [ion binding]; other site 1100841002797 Flavin Reductases; Region: FlaRed; cl00801 1100841002798 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1100841002799 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1100841002800 Restriction endonuclease; Region: Mrr_cat; pfam04471 1100841002801 AAA ATPase domain; Region: AAA_16; pfam13191 1100841002802 AAA domain; Region: AAA_22; pfam13401 1100841002803 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1100841002804 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1100841002805 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1100841002806 dimerization interface [polypeptide binding]; other site 1100841002807 hypothetical protein; Provisional; Region: PRK10281 1100841002808 hypothetical protein; Provisional; Region: PRK08296 1100841002809 membrane-bound PQQ-dependent dehydrogenase, glucose/quinate/shikimate family; Region: PQQ_membr_DH; TIGR03074 1100841002810 Membrane-bound PQQ-dependent glucose dehydrogenase; Region: PQQ_mGDH; cd10280 1100841002811 Trp docking motif [polypeptide binding]; other site 1100841002812 putative active site [active] 1100841002813 TniQ; Region: TniQ; pfam06527 1100841002814 Helix-turn-helix domain; Region: HTH_17; pfam12728 1100841002815 Bacterial TniB protein; Region: TniB; pfam05621 1100841002816 AAA domain; Region: AAA_22; pfam13401 1100841002817 Integrase core domain; Region: rve; pfam00665 1100841002818 TnsA endonuclease N terminal; Region: Tn7_Tnp_TnsA_N; pfam08722 1100841002819 phage-associated protein, BcepMu gp16 family; Region: BcepMu_gp16; TIGR04111 1100841002820 Protein of unknown function (DUF4007); Region: DUF4007; pfam13182 1100841002821 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 1100841002822 Active Sites [active] 1100841002823 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 1100841002824 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c_3; pfam13589 1100841002825 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1100841002826 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1100841002827 ATP binding site [chemical binding]; other site 1100841002828 Mg2+ binding site [ion binding]; other site 1100841002829 G-X-G motif; other site 1100841002830 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 1100841002831 dimer interface [polypeptide binding]; other site 1100841002832 putative radical transfer pathway; other site 1100841002833 diiron center [ion binding]; other site 1100841002834 tyrosyl radical; other site 1100841002835 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07207 1100841002836 ATP cone domain; Region: ATP-cone; pfam03477 1100841002837 Class I ribonucleotide reductase; Region: RNR_I; cd01679 1100841002838 active site 1100841002839 dimer interface [polypeptide binding]; other site 1100841002840 catalytic residues [active] 1100841002841 effector binding site; other site 1100841002842 R2 peptide binding site; other site 1100841002843 DNA-binding transcriptional regulator RstA; Provisional; Region: PRK10701 1100841002844 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1100841002845 active site 1100841002846 phosphorylation site [posttranslational modification] 1100841002847 intermolecular recognition site; other site 1100841002848 dimerization interface [polypeptide binding]; other site 1100841002849 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1100841002850 DNA binding site [nucleotide binding] 1100841002851 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1100841002852 dimerization interface [polypeptide binding]; other site 1100841002853 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1100841002854 dimer interface [polypeptide binding]; other site 1100841002855 phosphorylation site [posttranslational modification] 1100841002856 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1100841002857 ATP binding site [chemical binding]; other site 1100841002858 Mg2+ binding site [ion binding]; other site 1100841002859 G-X-G motif; other site 1100841002860 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1100841002861 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1100841002862 metal binding site [ion binding]; metal-binding site 1100841002863 active site 1100841002864 I-site; other site 1100841002865 NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602 1100841002866 NADH dehydrogenase subunit B; Validated; Region: PRK06411 1100841002867 bifunctional NADH:ubiquinone oxidoreductase subunit C/D; Provisional; Region: PRK11742 1100841002868 NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961 1100841002869 NADH dehydrogenase subunit D; Validated; Region: PRK06075 1100841002870 NADH dehydrogenase subunit E; Validated; Region: PRK07539 1100841002871 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 1100841002872 putative dimer interface [polypeptide binding]; other site 1100841002873 [2Fe-2S] cluster binding site [ion binding]; other site 1100841002874 NADH dehydrogenase I subunit F; Provisional; Region: PRK11278 1100841002875 SLBB domain; Region: SLBB; pfam10531 1100841002876 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928 1100841002877 NADH dehydrogenase subunit G; Validated; Region: PRK08166 1100841002878 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1100841002879 catalytic loop [active] 1100841002880 iron binding site [ion binding]; other site 1100841002881 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 1100841002882 MopB_NDH-1_NuoG2-N7: The second domain of the NuoG subunit (with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex in the respiratory...; Region: MopB_NDH-1_NuoG2-N7; cd02771 1100841002883 [4Fe-4S] binding site [ion binding]; other site 1100841002884 MopB_CT_NDH-1_NuoG2-N7: C-terminal region of the NuoG-like subunit (of the variant with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex...; Region: MopB_CT_NDH-1_NuoG2-N7; cd02788 1100841002885 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 1100841002886 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 1100841002887 NADH-quinone oxidoreductase, chain I; Region: NuoI; TIGR01971 1100841002888 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1100841002889 NADH:ubiquinone oxidoreductase subunit 6 (chain J) [Energy production and conversion]; Region: NuoJ; COG0839 1100841002890 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 1100841002891 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 1100841002892 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 1100841002893 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 1100841002894 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1100841002895 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 1100841002896 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1100841002897 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 1100841002898 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1100841002899 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1100841002900 active site 1100841002901 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1100841002902 DNA-binding site [nucleotide binding]; DNA binding site 1100841002903 RNA-binding motif; other site 1100841002904 putative DNA-binding transcriptional regulator; Provisional; Region: PRK10837 1100841002905 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1100841002906 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 1100841002907 putative dimerization interface [polypeptide binding]; other site 1100841002908 ferredoxin-NADP reductase; Provisional; Region: PRK10926 1100841002909 Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195 1100841002910 FAD binding pocket [chemical binding]; other site 1100841002911 FAD binding motif [chemical binding]; other site 1100841002912 phosphate binding motif [ion binding]; other site 1100841002913 beta-alpha-beta structure motif; other site 1100841002914 NAD binding pocket [chemical binding]; other site 1100841002915 Conserved TM helix; Region: TM_helix; pfam05552 1100841002916 Conserved TM helix; Region: TM_helix; pfam05552 1100841002917 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1100841002918 Conserved TM helix; Region: TM_helix; pfam05552 1100841002919 Conserved TM helix; Region: TM_helix; pfam05552 1100841002920 HI0933-like protein; Region: HI0933_like; pfam03486 1100841002921 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 1100841002922 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 1100841002923 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1100841002924 catalytic residue [active] 1100841002925 efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998 1100841002926 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1100841002927 HlyD family secretion protein; Region: HlyD_3; pfam13437 1100841002928 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1100841002929 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1100841002930 putative substrate translocation pore; other site 1100841002931 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1100841002932 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1100841002933 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 1100841002934 methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133 1100841002935 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 1100841002936 HIGH motif; other site 1100841002937 active site 1100841002938 KMSKS motif; other site 1100841002939 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 1100841002940 tRNA binding surface [nucleotide binding]; other site 1100841002941 anticodon binding site; other site 1100841002942 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 1100841002943 dimer interface [polypeptide binding]; other site 1100841002944 putative tRNA-binding site [nucleotide binding]; other site 1100841002945 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 1100841002946 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 1100841002947 Phosphorylase superfamily; Region: PNP_UDP_1; pfam01048 1100841002948 Uncharacterized protein conserved in bacteria (DUF2062); Region: DUF2062; pfam09835 1100841002949 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 1100841002950 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 1100841002951 trimer interface [polypeptide binding]; other site 1100841002952 active site 1100841002953 tRNA-dihydrouridine synthase C; Provisional; Region: PRK10550 1100841002954 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 1100841002955 FMN binding site [chemical binding]; other site 1100841002956 active site 1100841002957 catalytic residues [active] 1100841002958 substrate binding site [chemical binding]; other site 1100841002959 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 1100841002960 signal recognition particle protein; Provisional; Region: PRK10867 1100841002961 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 1100841002962 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 1100841002963 GTP binding site [chemical binding]; other site 1100841002964 Signal peptide binding domain; Region: SRP_SPB; pfam02978 1100841002965 pantothenate kinase; Reviewed; Region: PRK13322 1100841002966 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 1100841002967 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 1100841002968 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 1100841002969 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1100841002970 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1100841002971 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1100841002972 DNA-binding site [nucleotide binding]; DNA binding site 1100841002973 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 1100841002974 AAA domain; Region: AAA_23; pfam13476 1100841002975 Walker A/P-loop; other site 1100841002976 ATP binding site [chemical binding]; other site 1100841002977 Q-loop/lid; other site 1100841002978 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 1100841002979 ABC transporter signature motif; other site 1100841002980 Walker B; other site 1100841002981 D-loop; other site 1100841002982 H-loop/switch region; other site 1100841002983 ZipA, C-terminal FtsZ-binding domain; Region: ZipA_C; pfam04354 1100841002984 FtsZ protein binding site [polypeptide binding]; other site 1100841002985 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 1100841002986 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 1100841002987 nucleotide binding pocket [chemical binding]; other site 1100841002988 K-X-D-G motif; other site 1100841002989 catalytic site [active] 1100841002990 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 1100841002991 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 1100841002992 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 1100841002993 Dimer interface [polypeptide binding]; other site 1100841002994 BRCT sequence motif; other site 1100841002995 Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193 1100841002996 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 1100841002997 heme binding site [chemical binding]; other site 1100841002998 ferroxidase pore; other site 1100841002999 ferroxidase diiron center [ion binding]; other site 1100841003000 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1100841003001 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1100841003002 putative substrate translocation pore; other site 1100841003003 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 1100841003004 alpha,alpha-trehalose-phosphate synthase [UDP-forming]; Region: trehalose_OtsA; TIGR02400 1100841003005 active site 1100841003006 homotetramer interface [polypeptide binding]; other site 1100841003007 Trehalose-6-phosphatase [Carbohydrate transport and metabolism]; Region: OtsB; COG1877 1100841003008 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1100841003009 active site 1100841003010 motif I; other site 1100841003011 motif II; other site 1100841003012 carboxylesterase BioH; Provisional; Region: PRK10349 1100841003013 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1100841003014 adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK06173 1100841003015 inhibitor-cofactor binding pocket; inhibition site 1100841003016 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1100841003017 catalytic residue [active] 1100841003018 8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958 1100841003019 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 1100841003020 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1100841003021 catalytic residue [active] 1100841003022 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 1100841003023 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1100841003024 S-adenosylmethionine binding site [chemical binding]; other site 1100841003025 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 1100841003026 AAA domain; Region: AAA_26; pfam13500 1100841003027 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 1100841003028 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1100841003029 RNA binding surface [nucleotide binding]; other site 1100841003030 Pseudouridine synthase, Escherichia coli RluB like; Region: PseudoU_synth_RluB; cd02556 1100841003031 probable active site [active] 1100841003032 Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079 1100841003033 ScpA/B protein; Region: ScpA_ScpB; cl00598 1100841003034 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 1100841003035 Protein of unknown function, DUF462; Region: DUF462; pfam04315 1100841003036 Uncharacterized ACR, COG1399; Region: DUF177; pfam02620 1100841003037 50S ribosomal protein L32; Validated; Region: rpmF; PRK01110 1100841003038 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 1100841003039 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1100841003040 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 1100841003041 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 1100841003042 NAD(P) binding site [chemical binding]; other site 1100841003043 homotetramer interface [polypeptide binding]; other site 1100841003044 homodimer interface [polypeptide binding]; other site 1100841003045 active site 1100841003046 acyl carrier protein; Provisional; Region: acpP; PRK00982 1100841003047 LysM domain/BON superfamily protein; Provisional; Region: PRK11198 1100841003048 BON domain; Region: BON; pfam04972 1100841003049 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1100841003050 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 1100841003051 ATP binding site [chemical binding]; other site 1100841003052 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 1100841003053 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1100841003054 motif II; other site 1100841003055 3,4-dihydroxy-2-butanone 4-phosphate synthase; Provisional; Region: ribB; PRK03353 1100841003056 3,4-dihydroxy-2-butanone 4-phosphate synthase [Coenzyme metabolism]; Region: RibB; COG0108 1100841003057 Domain of unknown function (DUF4401); Region: DUF4401; pfam14351 1100841003058 GDYXXLXY protein; Region: GDYXXLXY; pfam14345 1100841003059 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 1100841003060 tetramerization interface [polypeptide binding]; other site 1100841003061 active site 1100841003062 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 1100841003063 putative active site [active] 1100841003064 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 1100841003065 5S rRNA interface [nucleotide binding]; other site 1100841003066 CTC domain interface [polypeptide binding]; other site 1100841003067 L16 interface [polypeptide binding]; other site 1100841003068 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 1100841003069 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 1100841003070 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1100841003071 active site 1100841003072 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00343 1100841003073 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 1100841003074 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 1100841003075 outer membrane lipoprotein LolB; Provisional; Region: lolB; PRK00022 1100841003076 Outer membrane lipoprotein LolB; Region: LolB; pfam03550 1100841003077 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1100841003078 binding surface 1100841003079 TPR motif; other site 1100841003080 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1100841003081 binding surface 1100841003082 TPR motif; other site 1100841003083 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 1100841003084 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 1100841003085 tRNA; other site 1100841003086 putative tRNA binding site [nucleotide binding]; other site 1100841003087 putative NADP binding site [chemical binding]; other site 1100841003088 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 1100841003089 DNA primase; Validated; Region: dnaG; PRK05667 1100841003090 CHC2 zinc finger; Region: zf-CHC2; pfam01807 1100841003091 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 1100841003092 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 1100841003093 active site 1100841003094 metal binding site [ion binding]; metal-binding site 1100841003095 interdomain interaction site; other site 1100841003096 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 1100841003097 Outer membrane lipoprotein; Region: YfiO; pfam13525 1100841003098 23S rRNA pseudouridine synthase D; Provisional; Region: rluD; PRK11180 1100841003099 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1100841003100 RNA binding surface [nucleotide binding]; other site 1100841003101 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1100841003102 active site 1100841003103 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 1100841003104 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 1100841003105 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 1100841003106 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1100841003107 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 1100841003108 SmpB-tmRNA interface; other site 1100841003109 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 1100841003110 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 1100841003111 active site 1100841003112 (T/H)XGH motif; other site 1100841003113 Phosphate-selective porin O and P; Region: Porin_O_P; pfam07396 1100841003114 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_9; cd08479 1100841003115 putative effector binding pocket; other site 1100841003116 putative dimerization interface [polypeptide binding]; other site 1100841003117 Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473 1100841003118 tartrate dehydrogenase; Region: TTC; TIGR02089 1100841003119 putative transporter; Provisional; Region: PRK09950 1100841003120 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1100841003121 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1100841003122 substrate binding pocket [chemical binding]; other site 1100841003123 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 1100841003124 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 1100841003125 [2Fe-2S] cluster binding site [ion binding]; other site 1100841003126 C-terminal catalytic domain of the oxygenase alpha subunit of an uncharacterized subgroup of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C_2; cd08886 1100841003127 putative alpha subunit interface [polypeptide binding]; other site 1100841003128 putative active site [active] 1100841003129 putative substrate binding site [chemical binding]; other site 1100841003130 Fe binding site [ion binding]; other site 1100841003131 succinic semialdehyde dehydrogenase; Region: PLN02278 1100841003132 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 1100841003133 tetramerization interface [polypeptide binding]; other site 1100841003134 NAD(P) binding site [chemical binding]; other site 1100841003135 catalytic residues [active] 1100841003136 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 1100841003137 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 1100841003138 FMN-binding pocket [chemical binding]; other site 1100841003139 flavin binding motif; other site 1100841003140 phosphate binding motif [ion binding]; other site 1100841003141 beta-alpha-beta structure motif; other site 1100841003142 NAD binding pocket [chemical binding]; other site 1100841003143 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1100841003144 catalytic loop [active] 1100841003145 iron binding site [ion binding]; other site 1100841003146 NAD synthetase; Provisional; Region: PRK13981 1100841003147 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 1100841003148 multimer interface [polypeptide binding]; other site 1100841003149 active site 1100841003150 catalytic triad [active] 1100841003151 protein interface 1 [polypeptide binding]; other site 1100841003152 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 1100841003153 homodimer interface [polypeptide binding]; other site 1100841003154 NAD binding pocket [chemical binding]; other site 1100841003155 ATP binding pocket [chemical binding]; other site 1100841003156 Mg binding site [ion binding]; other site 1100841003157 active-site loop [active] 1100841003158 Pirin; Region: Pirin; pfam02678 1100841003159 Pirin-related protein [General function prediction only]; Region: COG1741 1100841003160 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 1100841003161 Uncharacterized protein family (UPF0093); Region: UPF0093; pfam03653 1100841003162 3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK07967 1100841003163 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1100841003164 dimer interface [polypeptide binding]; other site 1100841003165 active site 1100841003166 EcsC protein family; Region: EcsC; pfam12787 1100841003167 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 1100841003168 S17 interaction site [polypeptide binding]; other site 1100841003169 S8 interaction site; other site 1100841003170 16S rRNA interaction site [nucleotide binding]; other site 1100841003171 streptomycin interaction site [chemical binding]; other site 1100841003172 23S rRNA interaction site [nucleotide binding]; other site 1100841003173 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 1100841003174 30S ribosomal protein S7; Validated; Region: PRK05302 1100841003175 elongation factor G; Reviewed; Region: PRK00007 1100841003176 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 1100841003177 G1 box; other site 1100841003178 putative GEF interaction site [polypeptide binding]; other site 1100841003179 GTP/Mg2+ binding site [chemical binding]; other site 1100841003180 Switch I region; other site 1100841003181 G2 box; other site 1100841003182 G3 box; other site 1100841003183 Switch II region; other site 1100841003184 G4 box; other site 1100841003185 G5 box; other site 1100841003186 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 1100841003187 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 1100841003188 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 1100841003189 elongation factor Tu; Reviewed; Region: PRK00049 1100841003190 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 1100841003191 G1 box; other site 1100841003192 GEF interaction site [polypeptide binding]; other site 1100841003193 GTP/Mg2+ binding site [chemical binding]; other site 1100841003194 Switch I region; other site 1100841003195 G2 box; other site 1100841003196 G3 box; other site 1100841003197 Switch II region; other site 1100841003198 G4 box; other site 1100841003199 G5 box; other site 1100841003200 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 1100841003201 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 1100841003202 Antibiotic Binding Site [chemical binding]; other site 1100841003203 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687 1100841003204 Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118 1100841003205 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687 1100841003206 Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118 1100841003207 ribosomal-protein-alanine N-acetyltransferase; Provisional; Region: rimI; PRK09491 1100841003208 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1100841003209 Coenzyme A binding pocket [chemical binding]; other site 1100841003210 arginyl-tRNA-protein transferase; Provisional; Region: PRK01305 1100841003211 Arginine-tRNA-protein transferase, N terminus; Region: ATE_N; pfam04376 1100841003212 Arginine-tRNA-protein transferase, C terminus; Region: ATE_C; pfam04377 1100841003213 leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301 1100841003214 thioredoxin reductase; Provisional; Region: PRK10262 1100841003215 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1100841003216 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1100841003217 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 1100841003218 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1100841003219 This domain directs oriented DNA translocation and forms a winged helix structure; Region: Ftsk_gamma; smart00843 1100841003220 threonine efflux system; Provisional; Region: PRK10229 1100841003221 Septum formation topological specificity factor MinE; Region: MinE; pfam03776 1100841003222 Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894 1100841003223 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 1100841003224 Switch I; other site 1100841003225 Switch II; other site 1100841003226 Septum formation inhibitor [Cell division and chromosome partitioning]; Region: MinC; COG0850 1100841003227 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 1100841003228 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1100841003229 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; Region: LPLAT_LCLAT1-like; cd07990 1100841003230 putative acyl-acceptor binding pocket; other site 1100841003231 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 1100841003232 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1100841003233 ligand binding site [chemical binding]; other site 1100841003234 ATP-dependent DNA helicase Rep; Region: rep; TIGR01074 1100841003235 Part of AAA domain; Region: AAA_19; pfam13245 1100841003236 Family description; Region: UvrD_C_2; pfam13538 1100841003237 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 1100841003238 trimer interface [polypeptide binding]; other site 1100841003239 active site 1100841003240 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 1100841003241 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 1100841003242 active site 1100841003243 substrate binding site [chemical binding]; other site 1100841003244 metal binding site [ion binding]; metal-binding site 1100841003245 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 1100841003246 feedback inhibition sensing region; other site 1100841003247 homohexameric interface [polypeptide binding]; other site 1100841003248 nucleotide binding site [chemical binding]; other site 1100841003249 N-acetyl-L-glutamate binding site [chemical binding]; other site 1100841003250 Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; pfam13444 1100841003251 Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121 1100841003252 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 1100841003253 putative dimer interface [polypeptide binding]; other site 1100841003254 putative active site [active] 1100841003255 Hemerythrin; Region: Hemerythrin; cd12107 1100841003256 Fe binding site [ion binding]; other site 1100841003257 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 1100841003258 hypothetical protein; Validated; Region: PRK01777 1100841003259 outer membrane biogenesis protein BamE; Provisional; Region: PRK11548 1100841003260 SmpA / OmlA family; Region: SmpA_OmlA; pfam04355 1100841003261 ferric uptake regulator; Provisional; Region: fur; PRK09462 1100841003262 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1100841003263 metal binding site 2 [ion binding]; metal-binding site 1100841003264 putative DNA binding helix; other site 1100841003265 metal binding site 1 [ion binding]; metal-binding site 1100841003266 dimer interface [polypeptide binding]; other site 1100841003267 structural Zn2+ binding site [ion binding]; other site 1100841003268 Tfp pilus assembly protein, ATPase PilU [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilU; COG5008 1100841003269 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1100841003270 Walker A motif; other site 1100841003271 ATP binding site [chemical binding]; other site 1100841003272 Walker B motif; other site 1100841003273 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 1100841003274 Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131 1100841003275 Walker A motif; other site 1100841003276 ATP binding site [chemical binding]; other site 1100841003277 Walker B motif; other site 1100841003278 Pyridoxal 5-phosphate (PLP)-binding TIM barrel domain of Type III PLP-Dependent Enzymes, Yggs-like proteins; Region: PLPDE_III_Yggs_like; cd06824 1100841003279 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1100841003280 catalytic residue [active] 1100841003281 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1100841003282 Walker A/P-loop; other site 1100841003283 ATP binding site [chemical binding]; other site 1100841003284 Q-loop/lid; other site 1100841003285 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1100841003286 ABC transporter signature motif; other site 1100841003287 Walker B; other site 1100841003288 D-loop; other site 1100841003289 H-loop/switch region; other site 1100841003290 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1100841003291 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 1100841003292 active site 1100841003293 metal binding site [ion binding]; metal-binding site 1100841003294 DNA binding site [nucleotide binding] 1100841003295 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 1100841003296 Organic hydroperoxide reductase [Secondary metabolites biosynthesis, transport and catabolism]; Region: osmC; COG1764 1100841003297 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 1100841003298 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1100841003299 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1100841003300 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 1100841003301 NAD(P) binding site [chemical binding]; other site 1100841003302 active site 1100841003303 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1100841003304 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1100841003305 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 1100841003306 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823 1100841003307 dimer interface [polypeptide binding]; other site 1100841003308 allosteric magnesium binding site [ion binding]; other site 1100841003309 active site 1100841003310 aspartate-rich active site metal binding site; other site 1100841003311 Schiff base residues; other site 1100841003312 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1100841003313 CoenzymeA binding site [chemical binding]; other site 1100841003314 subunit interaction site [polypeptide binding]; other site 1100841003315 PHB binding site; other site 1100841003316 efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998 1100841003317 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1100841003318 HlyD family secretion protein; Region: HlyD_3; pfam13437 1100841003319 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1100841003320 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1100841003321 putative substrate translocation pore; other site 1100841003322 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1100841003323 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 1100841003324 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 1100841003325 integrase; Provisional; Region: PRK09692 1100841003326 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 1100841003327 active site 1100841003328 Int/Topo IB signature motif; other site 1100841003329 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 1100841003330 putative catalytic site [active] 1100841003331 putative phosphate binding site [ion binding]; other site 1100841003332 putative metal binding site [ion binding]; other site 1100841003333 FRG domain; Region: FRG; pfam08867 1100841003334 Ead/Ea22-like protein; Region: Ead_Ea22; pfam13935 1100841003335 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 1100841003336 exodeoxyribonuclease X; Provisional; Region: PRK07983 1100841003337 active site 1100841003338 catalytic site [active] 1100841003339 substrate binding site [chemical binding]; other site 1100841003340 Uncharacterized conserved protein (DUF2303); Region: DUF2303; cl02338 1100841003341 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1100841003342 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1100841003343 non-specific DNA binding site [nucleotide binding]; other site 1100841003344 salt bridge; other site 1100841003345 sequence-specific DNA binding site [nucleotide binding]; other site 1100841003346 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1100841003347 Catalytic site [active] 1100841003348 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1100841003349 sequence-specific DNA binding site [nucleotide binding]; other site 1100841003350 salt bridge; other site 1100841003351 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 1100841003352 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 1100841003353 cofactor binding site; other site 1100841003354 DNA binding site [nucleotide binding] 1100841003355 substrate interaction site [chemical binding]; other site 1100841003356 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1100841003357 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1100841003358 Walker A motif; other site 1100841003359 ATP binding site [chemical binding]; other site 1100841003360 Walker B motif; other site 1100841003361 arginine finger; other site 1100841003362 Endodeoxyribonuclease RusA; Region: RusA; pfam05866 1100841003363 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1100841003364 non-specific DNA binding site [nucleotide binding]; other site 1100841003365 salt bridge; other site 1100841003366 sequence-specific DNA binding site [nucleotide binding]; other site 1100841003367 Glycine zipper 2TM domain; Region: Rick_17kDa_Anti; cl10470 1100841003368 Protein of unknown function (DUF1311); Region: DUF1311; pfam07007 1100841003369 Abi-like protein; Region: Abi_2; pfam07751 1100841003370 putative pectinesterase; Region: PLN02432; cl01911 1100841003371 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 1100841003372 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cl17442 1100841003373 protein-splicing catalytic site; other site 1100841003374 thioester formation/cholesterol transfer; other site 1100841003375 P22_AR N-terminal domain; Region: P22_AR_N; pfam10547 1100841003376 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153 1100841003377 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 1100841003378 Uncharacterized archaeal coiled-coil protein [Function unknown]; Region: COG1340 1100841003379 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 1100841003380 Domain of unknown function (DUF1983); Region: DUF1983; pfam09327 1100841003381 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1100841003382 putative Mg++ binding site [ion binding]; other site 1100841003383 Helicase_C-like; Region: Helicase_C_4; pfam13871 1100841003384 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1100841003385 S-adenosylmethionine binding site [chemical binding]; other site 1100841003386 TIGR02594 family protein; Region: TIGR02594 1100841003387 extracellular lipase, Pla-1/cef family; Region: lipase_Pla1_cef; TIGR03502 1100841003388 PAAR motif; Region: PAAR_motif; pfam05488 1100841003389 Y-family of DNA polymerases; Region: PolY; cl12025 1100841003390 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 1100841003391 glutamyl-tRNA reductase; Provisional; Region: PRK13940 1100841003392 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1100841003393 AAA domain; Region: AAA_21; pfam13304 1100841003394 Walker A/P-loop; other site 1100841003395 ATP binding site [chemical binding]; other site 1100841003396 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1100841003397 Walker B; other site 1100841003398 D-loop; other site 1100841003399 H-loop/switch region; other site 1100841003400 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dam; COG0338 1100841003401 outer membrane porin, OprD family; Region: OprD; pfam03573 1100841003402 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1100841003403 benzoate transport; Region: 2A0115; TIGR00895 1100841003404 putative substrate translocation pore; other site 1100841003405 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1100841003406 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 1100841003407 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 1100841003408 inhibitor site; inhibition site 1100841003409 active site 1100841003410 dimer interface [polypeptide binding]; other site 1100841003411 catalytic residue [active] 1100841003412 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1100841003413 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1100841003414 The C-teminal substrate binding domain of LysR-like nitrogen assimilation control (NAC) protein, contains the type 2 periplasmic binding fold; Region: PBP2_Nac; cd08433 1100841003415 putative dimerization interface [polypeptide binding]; other site 1100841003416 RNA polymerase sigma factor; Reviewed; Region: PRK12523 1100841003417 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1100841003418 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1100841003419 DNA binding residues [nucleotide binding] 1100841003420 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 1100841003421 FecR protein; Region: FecR; pfam04773 1100841003422 Secretin and TonB N terminus short domain; Region: STN; pfam07660 1100841003423 TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786 1100841003424 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 1100841003425 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 1100841003426 TPR repeat; Region: TPR_11; pfam13414 1100841003427 Protein of unknown function (DUF560); Region: DUF560; pfam04575 1100841003428 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 1100841003429 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cd00232 1100841003430 heme binding pocket [chemical binding]; other site 1100841003431 heme ligand [chemical binding]; other site 1100841003432 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2832 1100841003433 Protein of unknown function (DUF1275); Region: DUF1275; pfam06912 1100841003434 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1100841003435 PGAP1-like protein; Region: PGAP1; pfam07819 1100841003436 arginine-ornithine antiporter; Region: arg_ornith_anti; TIGR03810 1100841003437 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 1100841003438 Homocysteine/selenocysteine methylase (S-methylmethionine-dependent) [Amino acid transport and metabolism]; Region: MHT1; COG2040 1100841003439 malate:quinone oxidoreductase; Validated; Region: PRK05257 1100841003440 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 1100841003441 choline dehydrogenase; Validated; Region: PRK02106 1100841003442 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 1100841003443 betaine aldehyde dehydrogenase; Provisional; Region: PRK13252 1100841003444 NAD+-dependent 4-trimethylaminobutyraldehyde dehydrogenase, ALDH family 9A1; Region: ALDH_F9_TMBADH; cd07090 1100841003445 tetrameric interface [polypeptide binding]; other site 1100841003446 NAD binding site [chemical binding]; other site 1100841003447 catalytic residues [active] 1100841003448 transcriptional regulator BetI; Validated; Region: PRK00767 1100841003449 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1100841003450 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 1100841003451 BCCT family transporter; Region: BCCT; pfam02028 1100841003452 choline transport protein BetT; Provisional; Region: PRK09928 1100841003453 Multiple antibiotic transporter [Intracellular trafficking and secretion]; Region: MarC; COG2095 1100841003454 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 1100841003455 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 1100841003456 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1100841003457 C4-dicarboxylate transporter DctA; Reviewed; Region: PRK13027 1100841003458 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1100841003459 YaeQ protein; Region: YaeQ; pfam07152 1100841003460 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 1100841003461 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1100841003462 poly-beta-1,6-N-acetyl-D-glucosamine N-deacetylase PgaB; Region: deacetyl_PgaB; TIGR03938 1100841003463 N-terminal putative catalytic polysaccharide deacetylase domain of bacterial poly-beta-1,6-N-acetyl-D-glucosamine N-deacetylase PgaB, and similar proteins; Region: CE4_PgaB_5s; cd10964 1100841003464 putative active site [active] 1100841003465 putative metal binding site [ion binding]; other site 1100841003466 N-glycosyltransferase; Provisional; Region: PRK11204 1100841003467 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 1100841003468 DXD motif; other site 1100841003469 PgaD-like protein; Region: PgaD; pfam13994 1100841003470 enoyl-CoA hydratase; Provisional; Region: PRK06563 1100841003471 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1100841003472 substrate binding site [chemical binding]; other site 1100841003473 oxyanion hole (OAH) forming residues; other site 1100841003474 trimer interface [polypeptide binding]; other site 1100841003475 Nicotinamide mononucleotide transporter; Region: NMN_transporter; pfam04973 1100841003476 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 1100841003477 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1100841003478 Bacterial transcriptional regulator; Region: IclR; pfam01614 1100841003479 Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528 1100841003480 [2Fe-2S] cluster binding site [ion binding]; other site 1100841003481 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 1100841003482 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 1100841003483 [2Fe-2S] cluster binding site [ion binding]; other site 1100841003484 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 1100841003485 hydrophobic ligand binding site; other site 1100841003486 short chain dehydrogenase; Provisional; Region: PRK12939 1100841003487 classical (c) SDRs; Region: SDR_c; cd05233 1100841003488 NAD(P) binding site [chemical binding]; other site 1100841003489 active site 1100841003490 C-terminal domain of Burkholderia sp. NF100 MhqB and similar proteins; MhqB is a type I extradiol dioxygenase involved in the catabolism of methylhydroquinone, an intermediate in the degradation of fenitrothion; Region: MhqB_like_C; cd08360 1100841003491 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1100841003492 putative active site [active] 1100841003493 putative metal binding site [ion binding]; other site 1100841003494 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 1100841003495 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1100841003496 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1100841003497 D-galactonate transporter; Region: 2A0114; TIGR00893 1100841003498 putative substrate translocation pore; other site 1100841003499 Cupin domain; Region: Cupin_2; pfam07883 1100841003500 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1100841003501 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 1100841003502 short chain dehydrogenase; Provisional; Region: PRK07062 1100841003503 putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344 1100841003504 putative NAD(P) binding site [chemical binding]; other site 1100841003505 putative active site [active] 1100841003506 L-aspartate dehydrogenase; Provisional; Region: PRK13303 1100841003507 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 1100841003508 Domain of unknown function DUF108; Region: DUF108; pfam01958 1100841003509 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1100841003510 Uncharacterized Candidatus pelagibacter aldehyde dehydrogenase, DhaS-like; Region: ALDH_DhaS; cd07114 1100841003511 NAD(P) binding site [chemical binding]; other site 1100841003512 catalytic residues [active] 1100841003513 hypothetical protein; Provisional; Region: PRK07064 1100841003514 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1100841003515 PYR/PP interface [polypeptide binding]; other site 1100841003516 dimer interface [polypeptide binding]; other site 1100841003517 TPP binding site [chemical binding]; other site 1100841003518 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1100841003519 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 1100841003520 TPP-binding site [chemical binding]; other site 1100841003521 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1100841003522 metabolite-proton symporter; Region: 2A0106; TIGR00883 1100841003523 putative substrate translocation pore; other site 1100841003524 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 1100841003525 active site 1100841003526 catalytic residues [active] 1100841003527 metal binding site [ion binding]; metal-binding site 1100841003528 glutaminase; Provisional; Region: PRK00971 1100841003529 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 1100841003530 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1100841003531 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1100841003532 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1100841003533 putative substrate translocation pore; other site 1100841003534 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1100841003535 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 1100841003536 active site 1100841003537 catalytic residues [active] 1100841003538 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 1100841003539 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1100841003540 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 1100841003541 dimerization interface [polypeptide binding]; other site 1100841003542 substrate binding pocket [chemical binding]; other site 1100841003543 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1100841003544 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1100841003545 NAD(P) binding site [chemical binding]; other site 1100841003546 active site 1100841003547 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1100841003548 D-galactonate transporter; Region: 2A0114; TIGR00893 1100841003549 putative substrate translocation pore; other site 1100841003550 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 1100841003551 TPP-binding site [chemical binding]; other site 1100841003552 dimer interface [polypeptide binding]; other site 1100841003553 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 1100841003554 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1100841003555 PYR/PP interface [polypeptide binding]; other site 1100841003556 dimer interface [polypeptide binding]; other site 1100841003557 TPP binding site [chemical binding]; other site 1100841003558 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1100841003559 B12-dependent methionine synthase; Provisional; Region: metH; PRK09490 1100841003560 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 1100841003561 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 1100841003562 substrate binding pocket [chemical binding]; other site 1100841003563 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 1100841003564 B12 binding site [chemical binding]; other site 1100841003565 cobalt ligand [ion binding]; other site 1100841003566 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 1100841003567 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 1100841003568 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 1100841003569 D-Serine dehydratase is a pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of L- or D-serine to pyruvate and ammonia. D-serine dehydratase serves as a detoxifying enzyme in most E. coli strains where D-serine is a competitive...; Region: D-Ser-dehyd; cd06447 1100841003570 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 1100841003571 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1100841003572 catalytic residue [active] 1100841003573 Uncharacterized conserved protein [Function unknown]; Region: COG1262 1100841003574 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 1100841003575 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 1100841003576 Sulfatase; Region: Sulfatase; pfam00884 1100841003577 Rhomboid family; Region: Rhomboid; cl11446 1100841003578 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 1100841003579 IscR-regulated protein YhgI; Region: YhgI_GntY; TIGR03341 1100841003580 Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694 1100841003581 outer membrane receptor FepA; Provisional; Region: PRK13524 1100841003582 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1100841003583 N-terminal plug; other site 1100841003584 ligand-binding site [chemical binding]; other site 1100841003585 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 1100841003586 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1100841003587 nucleophilic elbow; other site 1100841003588 catalytic triad; other site 1100841003589 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378 1100841003590 active site clefts [active] 1100841003591 zinc binding site [ion binding]; other site 1100841003592 dimer interface [polypeptide binding]; other site 1100841003593 Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822 1100841003594 active site 1100841003595 catalytic triad [active] 1100841003596 oxyanion hole [active] 1100841003597 switch loop; other site 1100841003598 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG4181 1100841003599 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1100841003600 Walker A/P-loop; other site 1100841003601 ATP binding site [chemical binding]; other site 1100841003602 Q-loop/lid; other site 1100841003603 ABC transporter signature motif; other site 1100841003604 Walker B; other site 1100841003605 D-loop; other site 1100841003606 H-loop/switch region; other site 1100841003607 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127 1100841003608 FtsX-like permease family; Region: FtsX; pfam02687 1100841003609 FtsX-like permease family; Region: FtsX; pfam02687 1100841003610 Rhomboid family; Region: Rhomboid; pfam01694 1100841003611 monofunctional biosynthetic peptidoglycan transglycosylase; Provisional; Region: mtgA; PRK00056 1100841003612 Transglycosylase; Region: Transgly; cl17702 1100841003613 polyphosphate kinase; Provisional; Region: PRK05443 1100841003614 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 1100841003615 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 1100841003616 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 1100841003617 putative active site [active] 1100841003618 catalytic site [active] 1100841003619 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 1100841003620 putative active site [active] 1100841003621 putative domain interface [polypeptide binding]; other site 1100841003622 catalytic site [active] 1100841003623 Sporulation related domain; Region: SPOR; cl10051 1100841003624 DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151 1100841003625 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1100841003626 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 1100841003627 dimerization interface [polypeptide binding]; other site 1100841003628 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 1100841003629 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 1100841003630 NADH:flavorubredoxin oxidoreductase; Provisional; Region: PRK04965 1100841003631 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1100841003632 Rubredoxin [Energy production and conversion]; Region: COG1773 1100841003633 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 1100841003634 iron binding site [ion binding]; other site 1100841003635 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 1100841003636 putative hydrophobic ligand binding site [chemical binding]; other site 1100841003637 Uncharacterized protein family (UPF0227); Region: UPF0227; cl14886 1100841003638 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1100841003639 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 1100841003640 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 1100841003641 dimer interface [polypeptide binding]; other site 1100841003642 putative anticodon binding site; other site 1100841003643 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 1100841003644 motif 1; other site 1100841003645 active site 1100841003646 motif 2; other site 1100841003647 motif 3; other site 1100841003648 Capsule assembly protein Wzi; Region: Caps_assemb_Wzi; pfam14052 1100841003649 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 1100841003650 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 1100841003651 Active Sites [active] 1100841003652 sulfate adenylyltransferase subunit 1; Provisional; Region: cysN; PRK05124 1100841003653 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 1100841003654 CysD dimerization site [polypeptide binding]; other site 1100841003655 G1 box; other site 1100841003656 putative GEF interaction site [polypeptide binding]; other site 1100841003657 GTP/Mg2+ binding site [chemical binding]; other site 1100841003658 Switch I region; other site 1100841003659 G2 box; other site 1100841003660 G3 box; other site 1100841003661 Switch II region; other site 1100841003662 G4 box; other site 1100841003663 G5 box; other site 1100841003664 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 1100841003665 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 1100841003666 Uncharacterized protein conserved in bacteria (DUF2239); Region: DUF2239; pfam09998 1100841003667 H+/citrate symporter [Energy production and conversion]; Region: CitM; COG2851 1100841003668 Citrate transporter; Region: CitMHS; pfam03600 1100841003669 Domain of unknown function DUF21; Region: DUF21; pfam01595 1100841003670 FOG: CBS domain [General function prediction only]; Region: COG0517 1100841003671 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1100841003672 Transporter associated domain; Region: CorC_HlyC; smart01091 1100841003673 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1100841003674 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1100841003675 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 1100841003676 substrate binding pocket [chemical binding]; other site 1100841003677 dimerization interface [polypeptide binding]; other site 1100841003678 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 1100841003679 tetramer interface [polypeptide binding]; other site 1100841003680 active site 1100841003681 Mg2+/Mn2+ binding site [ion binding]; other site 1100841003682 isocitrate lyase; Region: PLN02892 1100841003683 Uncharacterized lipoprotein NlpE involved in copper resistance [Cell envelope biogenesis, outer membrane / Inorganic ion transport and metabolism]; Region: CutF; COG3015 1100841003684 NlpE N-terminal domain; Region: NlpE; pfam04170 1100841003685 UreD urease accessory protein; Region: UreD; pfam01774 1100841003686 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 1100841003687 alpha-gamma subunit interface [polypeptide binding]; other site 1100841003688 beta-gamma subunit interface [polypeptide binding]; other site 1100841003689 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 1100841003690 gamma-beta subunit interface [polypeptide binding]; other site 1100841003691 alpha-beta subunit interface [polypeptide binding]; other site 1100841003692 urease subunit alpha; Reviewed; Region: ureC; PRK13207 1100841003693 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 1100841003694 subunit interactions [polypeptide binding]; other site 1100841003695 active site 1100841003696 flap region; other site 1100841003697 urease accessory protein UreE; Provisional; Region: ureE; PRK13261 1100841003698 UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571 1100841003699 dimer interface [polypeptide binding]; other site 1100841003700 catalytic residues [active] 1100841003701 Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830 1100841003702 UreF; Region: UreF; pfam01730 1100841003703 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1100841003704 HupE / UreJ protein; Region: HupE_UreJ; pfam04955 1100841003705 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 1100841003706 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1100841003707 S-adenosylmethionine binding site [chemical binding]; other site 1100841003708 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 1100841003709 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1100841003710 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1100841003711 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399 1100841003712 adenylate kinase; Reviewed; Region: adk; PRK00279 1100841003713 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 1100841003714 AMP-binding site [chemical binding]; other site 1100841003715 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 1100841003716 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 1100841003717 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1100841003718 minor groove reading motif; other site 1100841003719 helix-hairpin-helix signature motif; other site 1100841003720 substrate binding pocket [chemical binding]; other site 1100841003721 active site 1100841003722 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 1100841003723 ferredoxin; Provisional; Region: PRK08764 1100841003724 Putative Fe-S cluster; Region: FeS; cl17515 1100841003725 4Fe-4S binding domain; Region: Fer4; pfam00037 1100841003726 glutamate dehydrogenase; Provisional; Region: PRK09414 1100841003727 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 1100841003728 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 1100841003729 NAD(P) binding site [chemical binding]; other site 1100841003730 META domain; Region: META; pfam03724 1100841003731 META domain; Region: META; pfam03724 1100841003732 Domain of unknown function (DUF4377); Region: DUF4377; pfam14302 1100841003733 The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363 1100841003734 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 1100841003735 putative active site [active] 1100841003736 metal binding site [ion binding]; metal-binding site 1100841003737 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 1100841003738 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 1100841003739 Found in ATP-dependent protease La (LON); Region: LON; smart00464 1100841003740 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1100841003741 Walker A motif; other site 1100841003742 ATP binding site [chemical binding]; other site 1100841003743 Walker B motif; other site 1100841003744 arginine finger; other site 1100841003745 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 1100841003746 Extended Signal Peptide of Type V secretion system; Region: ESPR; pfam13018 1100841003747 YadA-like, left-handed beta-roll; Region: LbR_YadA-like; cd12820 1100841003748 trimer interface [polypeptide binding]; other site 1100841003749 YadA-like, left-handed beta-roll; Region: LbR_YadA-like; cd12820 1100841003750 trimer interface [polypeptide binding]; other site 1100841003751 Left-handed beta-roll, including virulence factors and various other proteins; Region: LbR-like; cl17507 1100841003752 trimer interface [polypeptide binding]; other site 1100841003753 YadA-like, left-handed beta-roll; Region: LbR_YadA-like; cd12820 1100841003754 trimer interface [polypeptide binding]; other site 1100841003755 YadA-like, left-handed beta-roll; Region: LbR_YadA-like; cd12820 1100841003756 trimer interface [polypeptide binding]; other site 1100841003757 YadA-like C-terminal region; Region: YadA; pfam03895 1100841003758 SmpA / OmlA family; Region: SmpA_OmlA; pfam04355 1100841003759 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 1100841003760 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1100841003761 ligand binding site [chemical binding]; other site 1100841003762 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 1100841003763 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 1100841003764 serine hydroxymethyltransferase; Reviewed; Region: PRK13034 1100841003765 Helix-turn-helix domain; Region: HTH_17; cl17695 1100841003766 AAA domain; Region: AAA_24; pfam13479 1100841003767 phage nucleotide-binding protein; Region: phage_P_loop; TIGR01618 1100841003768 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1100841003769 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1100841003770 non-specific DNA binding site [nucleotide binding]; other site 1100841003771 salt bridge; other site 1100841003772 sequence-specific DNA binding site [nucleotide binding]; other site 1100841003773 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1100841003774 Catalytic site [active] 1100841003775 Bacteriophage replication protein O; Region: Phage_rep_O; cl04545 1100841003776 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 1100841003777 putative active site [active] 1100841003778 glutaminyl-tRNA synthetase; Provisional; Region: PTZ00437 1100841003779 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 1100841003780 Phage protein (N4 Gp49/phage Sf6 gene 66) family; Region: Phage_gp49_66; pfam13876 1100841003781 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 1100841003782 LEM-like domain of lamina-associated polypeptide 2 (LAP2) and similar proteins; Region: LEM_like; cd12935 1100841003783 Bacteriophage related domain of unknown function; Region: DUF4128; pfam13554 1100841003784 Bacterial SH3 domain homologues; Region: SH3b; smart00287 1100841003785 DNA-binding transcriptional activator MhpR; Provisional; Region: PRK09834 1100841003786 Domain of unknown function (DUF4258); Region: DUF4258; pfam14076 1100841003787 Predicted transcriptional regulator [Transcription]; Region: COG2944 1100841003788 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1100841003789 non-specific DNA binding site [nucleotide binding]; other site 1100841003790 salt bridge; other site 1100841003791 sequence-specific DNA binding site [nucleotide binding]; other site 1100841003792 Phage-related minor tail protein [Function unknown]; Region: COG5281 1100841003793 tape measure domain; Region: tape_meas_nterm; TIGR02675 1100841003794 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1100841003795 Peptidase family M23; Region: Peptidase_M23; pfam01551 1100841003796 Domain of unknown function (DUF1833); Region: DUF1833; pfam08875 1100841003797 Glycosyl hydrolase 108; Region: Glyco_hydro_108; pfam05838 1100841003798 Predicted Peptidoglycan domain; Region: PG_binding_3; pfam09374 1100841003799 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 1100841003800 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 1100841003801 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 1100841003802 putative metal dependent hydrolase; Provisional; Region: PRK11598 1100841003803 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 1100841003804 Sulfatase; Region: Sulfatase; pfam00884 1100841003805 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1100841003806 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 1100841003807 active site 1100841003808 Int/Topo IB signature motif; other site 1100841003809 DNA binding site [nucleotide binding] 1100841003810 Helix-turn-helix domain; Region: HTH_17; cl17695 1100841003811 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cl17512 1100841003812 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1100841003813 non-specific DNA binding site [nucleotide binding]; other site 1100841003814 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 1100841003815 salt bridge; other site 1100841003816 sequence-specific DNA binding site [nucleotide binding]; other site 1100841003817 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1100841003818 Catalytic site [active] 1100841003819 Protein of unknown function (DUF1376); Region: DUF1376; cl01531 1100841003820 Conserved phage C-terminus (Phg_2220_C); Region: Phg_2220_C; cl09752 1100841003821 potential frameshift: common BLAST hit: gi|387124694|ref|YP_006290576.1| replicative DNA helicase 1100841003822 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 1100841003823 DnaB-like helicase C terminal domain; Region: DnaB_C; pfam03796 1100841003824 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 1100841003825 Walker A motif; other site 1100841003826 ATP binding site [chemical binding]; other site 1100841003827 Walker B motif; other site 1100841003828 DNA binding loops [nucleotide binding] 1100841003829 RIO kinase family, catalytic domain. The RIO kinase catalytic domain family is part of a larger superfamily, that includes the catalytic domains of other kinases such as the typical serine/threonine/tyrosine protein kinases (PKs), aminoglycoside...; Region: RIO; cl17248 1100841003830 Phage antitermination protein Q; Region: Phage_antitermQ; pfam06530 1100841003831 NinB protein; Region: NinB; pfam05772 1100841003832 Terminase small subunit; Region: Terminase_2; cl01513 1100841003833 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 1100841003834 Phage-related protein [Function unknown]; Region: COG4695 1100841003835 Phage portal protein; Region: Phage_portal; pfam04860 1100841003836 Caudovirus prohead protease; Region: Peptidase_U35; pfam04586 1100841003837 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 1100841003838 Syntaxin N-terminus domain; syntaxins are nervous system-specific proteins implicated in the docking of synaptic vesicles with the presynaptic plasma membrane; they are a family of receptors for intracellular transport vesicles; each target membrane may...; Region: SynN; cl00143 1100841003839 interdomain interaction site; other site 1100841003840 Phage capsid family; Region: Phage_capsid; pfam05065 1100841003841 Head-Tail Connector Proteins gp6 and gp15, and similar proteins; Region: gp6_gp15_like; cl12049 1100841003842 Phage head-tail joining protein; Region: Phage_H_T_join; pfam05521 1100841003843 Bacteriophage protein of unknown function (DUF646); Region: DUF646; pfam04883 1100841003844 Protein of unknown function (DUF3168); Region: DUF3168; pfam11367 1100841003845 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 1100841003846 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1100841003847 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1100841003848 catalytic residue [active] 1100841003849 Domain of unknown function (DUF1833); Region: DUF1833; pfam08875 1100841003850 K+ potassium transporter; Region: K_trans; cl15781 1100841003851 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 1100841003852 catalytic residue [active] 1100841003853 Fungal domain of unknown function (DUF1750); Region: SWI-SNF_Ssr4; pfam08549 1100841003854 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1100841003855 active site 1100841003856 DNA binding site [nucleotide binding] 1100841003857 Int/Topo IB signature motif; other site 1100841003858 Cell division protein ZapA; Region: ZapA; pfam05164 1100841003859 Uncharacterized protein family (UPF0149); Region: UPF0149; pfam03695 1100841003860 Aminopeptidase P, N-terminal domain; Region: AMP_N; pfam05195 1100841003861 proline aminopeptidase P II; Provisional; Region: PRK10879 1100841003862 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 1100841003863 active site 1100841003864 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1100841003865 Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988 1100841003866 Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988 1100841003867 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1100841003868 Cd(II)/Pb(II)-responsive transcriptional regulator; Region: CadR-PbrR; TIGR02047 1100841003869 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 1100841003870 DNA binding residues [nucleotide binding] 1100841003871 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 1100841003872 Lysine efflux permease [General function prediction only]; Region: COG1279 1100841003873 chromosome replication initiation inhibitor protein; Validated; Region: PRK03635 1100841003874 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1100841003875 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1100841003876 dimerization interface [polypeptide binding]; other site 1100841003877 Menaquinone biosynthesis; Region: VitK2_biosynth; cl17475 1100841003878 Predicted methyltransferases [General function prediction only]; Region: COG0313 1100841003879 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 1100841003880 putative SAM binding site [chemical binding]; other site 1100841003881 putative homodimer interface [polypeptide binding]; other site 1100841003882 hypothetical protein; Provisional; Region: PRK14674 1100841003883 outer membrane lipoprotein; Provisional; Region: PRK11023 1100841003884 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1100841003885 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1100841003886 substrate binding pocket [chemical binding]; other site 1100841003887 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1100841003888 NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296 1100841003889 NADH pyrophosphatase; Reviewed; Region: nudC; PRK00241 1100841003890 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 1100841003891 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 1100841003892 putative NADH binding site [chemical binding]; other site 1100841003893 putative active site [active] 1100841003894 nudix motif; other site 1100841003895 putative metal binding site [ion binding]; other site 1100841003896 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 1100841003897 RNA/DNA hybrid binding site [nucleotide binding]; other site 1100841003898 active site 1100841003899 DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406 1100841003900 DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131 1100841003901 active site 1100841003902 catalytic site [active] 1100841003903 substrate binding site [chemical binding]; other site 1100841003904 membrane-bound lytic murein transglycosylase D; Provisional; Region: mltD; PRK10783 1100841003905 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1100841003906 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1100841003907 catalytic residue [active] 1100841003908 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1100841003909 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1100841003910 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1100841003911 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 1100841003912 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1100841003913 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1100841003914 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 1100841003915 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1100841003916 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 1100841003917 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1100841003918 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1100841003919 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 1100841003920 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497 1100841003921 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 1100841003922 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4174 1100841003923 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1100841003924 dimer interface [polypeptide binding]; other site 1100841003925 conserved gate region; other site 1100841003926 ABC-ATPase subunit interface; other site 1100841003927 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4239 1100841003928 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1100841003929 dimer interface [polypeptide binding]; other site 1100841003930 conserved gate region; other site 1100841003931 putative PBP binding loops; other site 1100841003932 ABC-ATPase subunit interface; other site 1100841003933 ABC-type uncharacterized transport system, duplicated ATPase component [General function prediction only]; Region: COG4172 1100841003934 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1100841003935 Walker A/P-loop; other site 1100841003936 ATP binding site [chemical binding]; other site 1100841003937 Q-loop/lid; other site 1100841003938 ABC transporter signature motif; other site 1100841003939 Walker B; other site 1100841003940 D-loop; other site 1100841003941 H-loop/switch region; other site 1100841003942 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1100841003943 Walker A/P-loop; other site 1100841003944 ATP binding site [chemical binding]; other site 1100841003945 Q-loop/lid; other site 1100841003946 ABC transporter signature motif; other site 1100841003947 Walker B; other site 1100841003948 D-loop; other site 1100841003949 H-loop/switch region; other site 1100841003950 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1100841003951 Old yellow enzyme (OYE)-related FMN binding domain, group 2. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_2_FMN; cd04733 1100841003952 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1100841003953 putative active site [active] 1100841003954 putative FMN binding site [chemical binding]; other site 1100841003955 putative substrate binding site [chemical binding]; other site 1100841003956 putative catalytic residue [active] 1100841003957 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 1100841003958 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1100841003959 N-terminal plug; other site 1100841003960 ligand-binding site [chemical binding]; other site 1100841003961 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 1100841003962 DEDDh 3'-5' exonuclease domain of RNase T; Region: RNaseT; cd06134 1100841003963 dimer interface [polypeptide binding]; other site 1100841003964 catalytic site [active] 1100841003965 putative active site [active] 1100841003966 putative substrate binding site [chemical binding]; other site 1100841003967 Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294 1100841003968 active site 1100841003969 substrate binding pocket [chemical binding]; other site 1100841003970 dimer interface [polypeptide binding]; other site 1100841003971 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1100841003972 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1100841003973 metal binding site [ion binding]; metal-binding site 1100841003974 active site 1100841003975 I-site; other site 1100841003976 argininosuccinate synthase; Provisional; Region: PRK13820 1100841003977 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 1100841003978 ANP binding site [chemical binding]; other site 1100841003979 Substrate Binding Site II [chemical binding]; other site 1100841003980 Substrate Binding Site I [chemical binding]; other site 1100841003981 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1100841003982 2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930 1100841003983 active site 1100841003984 FMN binding site [chemical binding]; other site 1100841003985 2,4-decadienoyl-CoA binding site; other site 1100841003986 catalytic residue [active] 1100841003987 4Fe-4S cluster binding site [ion binding]; other site 1100841003988 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 1100841003989 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1100841003990 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 1100841003991 Bacterial protein of unknown function (DUF898); Region: DUF898; pfam05987 1100841003992 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 1100841003993 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 1100841003994 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1100841003995 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1100841003996 Uncharacterized protein conserved in bacteria [Function unknown]; Region: VgrG; COG3501 1100841003997 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 1100841003998 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 1100841003999 Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296 1100841004000 Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; pfam10106 1100841004001 RHS Repeat; Region: RHS_repeat; pfam05593 1100841004002 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 1100841004003 RHS Repeat; Region: RHS_repeat; pfam05593 1100841004004 RHS Repeat; Region: RHS_repeat; pfam05593 1100841004005 RHS Repeat; Region: RHS_repeat; pfam05593 1100841004006 RHS Repeat; Region: RHS_repeat; cl11982 1100841004007 RHS protein; Region: RHS; pfam03527 1100841004008 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 1100841004009 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 1100841004010 Sel1-like repeats; Region: SEL1; smart00671 1100841004011 Sel1-like repeats; Region: SEL1; smart00671 1100841004012 Sel1-like repeats; Region: SEL1; smart00671 1100841004013 Sel1-like repeats; Region: SEL1; smart00671 1100841004014 Sel1-like repeats; Region: SEL1; smart00671 1100841004015 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 1100841004016 Sel1-like repeats; Region: SEL1; smart00671 1100841004017 Sel1-like repeats; Region: SEL1; smart00671 1100841004018 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 1100841004019 Sel1 repeat; Region: Sel1; cl02723 1100841004020 Sel1-like repeats; Region: SEL1; smart00671 1100841004021 Sel1-like repeats; Region: SEL1; smart00671 1100841004022 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 1100841004023 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 1100841004024 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1100841004025 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 1100841004026 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1100841004027 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1100841004028 DNA-binding site [nucleotide binding]; DNA binding site 1100841004029 FCD domain; Region: FCD; pfam07729 1100841004030 SnoaL-like domain; Region: SnoaL_2; pfam12680 1100841004031 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 1100841004032 gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK13473 1100841004033 Escherichia coli NAD+-dependent gamma-aminobutyraldehyde dehydrogenase YdcW-like; Region: ALDH_ABALDH-YdcW; cd07092 1100841004034 tetrameric interface [polypeptide binding]; other site 1100841004035 NAD binding site [chemical binding]; other site 1100841004036 catalytic residues [active] 1100841004037 substrate binding site [chemical binding]; other site 1100841004038 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1100841004039 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 1100841004040 AsnC family; Region: AsnC_trans_reg; pfam01037 1100841004041 bifunctional succinylornithine transaminase/acetylornithine transaminase; Provisional; Region: PRK12381 1100841004042 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1100841004043 inhibitor-cofactor binding pocket; inhibition site 1100841004044 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1100841004045 catalytic residue [active] 1100841004046 Arginine/ornithine N-succinyltransferase beta subunit [Amino acid transport and metabolism]; Region: AstA; COG3138 1100841004047 Arginine N-succinyltransferase beta subunit; Region: AstA; cl11440 1100841004048 D-alanine/D-serine/glycine permease; Provisional; Region: PRK11049 1100841004049 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 1100841004050 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 1100841004051 Integrase core domain; Region: rve; pfam00665 1100841004052 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; pfam01526 1100841004053 multiple promoter invertase; Provisional; Region: mpi; PRK13413 1100841004054 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 1100841004055 catalytic residues [active] 1100841004056 catalytic nucleophile [active] 1100841004057 Presynaptic Site I dimer interface [polypeptide binding]; other site 1100841004058 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 1100841004059 Synaptic Flat tetramer interface [polypeptide binding]; other site 1100841004060 Synaptic Site I dimer interface [polypeptide binding]; other site 1100841004061 DNA binding site [nucleotide binding] 1100841004062 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 1100841004063 DNA-binding interface [nucleotide binding]; DNA binding site 1100841004064 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 1100841004065 Transposase; Region: HTH_Tnp_1; cl17663 1100841004066 Integrase core domain; Region: rve; pfam00665 1100841004067 Pirin-related protein [General function prediction only]; Region: COG1741 1100841004068 Pirin; Region: Pirin; pfam02678 1100841004069 Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118 1100841004070 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687 1100841004071 classical (c) SDRs; Region: SDR_c; cd05233 1100841004072 short chain dehydrogenase; Provisional; Region: PRK05650 1100841004073 NAD(P) binding site [chemical binding]; other site 1100841004074 active site 1100841004075 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1100841004076 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1100841004077 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 1100841004078 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 1100841004079 Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320 1100841004080 active site 1100841004081 purine riboside binding site [chemical binding]; other site 1100841004082 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 1100841004083 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 1100841004084 RNA/DNA hybrid binding site [nucleotide binding]; other site 1100841004085 active site 1100841004086 carbon storage regulator; Provisional; Region: PRK01712 1100841004087 aspartate kinase; Reviewed; Region: PRK06635 1100841004088 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 1100841004089 putative nucleotide binding site [chemical binding]; other site 1100841004090 putative catalytic residues [active] 1100841004091 putative Mg ion binding site [ion binding]; other site 1100841004092 putative aspartate binding site [chemical binding]; other site 1100841004093 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 1100841004094 putative allosteric regulatory site; other site 1100841004095 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 1100841004096 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 1100841004097 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 1100841004098 motif 1; other site 1100841004099 active site 1100841004100 motif 2; other site 1100841004101 motif 3; other site 1100841004102 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 1100841004103 DHHA1 domain; Region: DHHA1; pfam02272 1100841004104 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 1100841004105 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 1100841004106 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 1100841004107 ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: PRK12421 1100841004108 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 1100841004109 dimer interface [polypeptide binding]; other site 1100841004110 motif 1; other site 1100841004111 active site 1100841004112 motif 2; other site 1100841004113 motif 3; other site 1100841004114 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 1100841004115 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1100841004116 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 1100841004117 Peptidase family M48; Region: Peptidase_M48; pfam01435 1100841004118 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1100841004119 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1100841004120 active site 1100841004121 catalytic tetrad [active] 1100841004122 DNA-binding transcriptional dual regulator Crp; Provisional; Region: PRK11753 1100841004123 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1100841004124 ligand binding site [chemical binding]; other site 1100841004125 flexible hinge region; other site 1100841004126 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1100841004127 putative switch regulator; other site 1100841004128 non-specific DNA interactions [nucleotide binding]; other site 1100841004129 DNA binding site [nucleotide binding] 1100841004130 sequence specific DNA binding site [nucleotide binding]; other site 1100841004131 putative cAMP binding site [chemical binding]; other site 1100841004132 OsmC-like protein; Region: OsmC; cl00767 1100841004133 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1100841004134 Coenzyme A binding pocket [chemical binding]; other site 1100841004135 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1100841004136 Peptidase family M23; Region: Peptidase_M23; pfam01551 1100841004137 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 1100841004138 Clp amino terminal domain; Region: Clp_N; pfam02861 1100841004139 Clp amino terminal domain; Region: Clp_N; pfam02861 1100841004140 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1100841004141 Walker A motif; other site 1100841004142 ATP binding site [chemical binding]; other site 1100841004143 Walker B motif; other site 1100841004144 arginine finger; other site 1100841004145 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1100841004146 Walker A motif; other site 1100841004147 ATP binding site [chemical binding]; other site 1100841004148 Walker B motif; other site 1100841004149 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1100841004150 Competence-damaged protein; Region: CinA; pfam02464 1100841004151 23S rRNA m(2)G2445 methyltransferase; Provisional; Region: rlmL; PRK11783 1100841004152 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 1100841004153 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1100841004154 DNA methylase; Region: N6_N4_Mtase; cl17433 1100841004155 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 1100841004156 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1100841004157 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1100841004158 dihydroorotase; Validated; Region: pyrC; PRK09357 1100841004159 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 1100841004160 active site 1100841004161 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 1100841004162 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1100841004163 ligand binding site [chemical binding]; other site 1100841004164 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 1100841004165 Domain of unknown function (DUF2520); Region: DUF2520; pfam10728 1100841004166 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 1100841004167 GST_N family, unknown subfamily 2; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_2; cd03047 1100841004168 putative C-terminal domain interface [polypeptide binding]; other site 1100841004169 putative GSH binding site (G-site) [chemical binding]; other site 1100841004170 putative dimer interface [polypeptide binding]; other site 1100841004171 C-terminal, alpha helical domain of an unknown subfamily 2 of Glutathione S-transferases; Region: GST_C_2; cd03180 1100841004172 putative N-terminal domain interface [polypeptide binding]; other site 1100841004173 putative dimer interface [polypeptide binding]; other site 1100841004174 putative substrate binding pocket (H-site) [chemical binding]; other site 1100841004175 tRNA (guanine-N(7)-)-methyltransferase; Reviewed; Region: trmB; PRK00121 1100841004176 Predicted extracellular nuclease [General function prediction only]; Region: COG2374 1100841004177 YhcR_OBF_like: A subfamily of OB-fold domains similar to the OB folds of Bacillus subtilis YhcR. YhcR is a sugar-nonspecific nuclease, which is active in the presence of Ca2+ and Mn2+. It cleaves RNA endonucleolytically, producing 3'-monophosphate...; Region: YhcR_OBF_like; cd04486 1100841004178 generic binding surface II; other site 1100841004179 generic binding surface I; other site 1100841004180 Mycoplasma pulmonis MnuA nuclease-like; Region: MnuA_DNase1-like; cd10283 1100841004181 putative active site [active] 1100841004182 putative catalytic site [active] 1100841004183 putative Mg binding site IVb [ion binding]; other site 1100841004184 putative phosphate binding site [ion binding]; other site 1100841004185 putative DNA binding site [nucleotide binding]; other site 1100841004186 putative Mg binding site IVa [ion binding]; other site 1100841004187 glutathionine S-transferase; Provisional; Region: PRK10542 1100841004188 GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057 1100841004189 C-terminal domain interface [polypeptide binding]; other site 1100841004190 GSH binding site (G-site) [chemical binding]; other site 1100841004191 dimer interface [polypeptide binding]; other site 1100841004192 C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188 1100841004193 dimer interface [polypeptide binding]; other site 1100841004194 N-terminal domain interface [polypeptide binding]; other site 1100841004195 substrate binding pocket (H-site) [chemical binding]; other site 1100841004196 alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317 1100841004197 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974 1100841004198 catalytic residue [active] 1100841004199 TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026 1100841004200 catalytic residues [active] 1100841004201 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1100841004202 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1100841004203 Protein of unknown function (DUF1653); Region: DUF1653; pfam07866 1100841004204 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 1100841004205 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1100841004206 S-adenosylmethionine binding site [chemical binding]; other site 1100841004207 KTSC domain; Region: KTSC; pfam13619 1100841004208 peroxiredoxin; Region: AhpC; TIGR03137 1100841004209 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 1100841004210 dimer interface [polypeptide binding]; other site 1100841004211 decamer (pentamer of dimers) interface [polypeptide binding]; other site 1100841004212 catalytic triad [active] 1100841004213 peroxidatic and resolving cysteines [active] 1100841004214 ATP-dependent helicase HrpA; Region: DEAH_box_HrpA; TIGR01967 1100841004215 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1100841004216 ATP binding site [chemical binding]; other site 1100841004217 putative Mg++ binding site [ion binding]; other site 1100841004218 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1100841004219 nucleotide binding region [chemical binding]; other site 1100841004220 ATP-binding site [chemical binding]; other site 1100841004221 Helicase associated domain (HA2); Region: HA2; pfam04408 1100841004222 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 1100841004223 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 1100841004224 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK07515 1100841004225 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 1100841004226 dimer interface [polypeptide binding]; other site 1100841004227 active site 1100841004228 CoA binding pocket [chemical binding]; other site 1100841004229 outer membrane porin, OprD family; Region: OprD; pfam03573 1100841004230 benzoate transport; Region: 2A0115; TIGR00895 1100841004231 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1100841004232 putative substrate translocation pore; other site 1100841004233 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1100841004234 putative substrate translocation pore; other site 1100841004235 benzoate transporter; Region: benE; TIGR00843 1100841004236 Benzoate membrane transport protein; Region: BenE; pfam03594 1100841004237 1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate dehydrogenase; Provisional; Region: benD; PRK12823 1100841004238 1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate dehydrogenase (DHB DH)-like, classical (c) SDR; Region: DHB_DH-like_SDR_c; cd08937 1100841004239 putative NAD(P) binding site [chemical binding]; other site 1100841004240 active site 1100841004241 anthranilate dioxygenase reductase; Provisional; Region: antC; PRK11872 1100841004242 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1100841004243 catalytic loop [active] 1100841004244 iron binding site [ion binding]; other site 1100841004245 Benzoate dioxygenase reductase (BenDO) FAD/NAD binding domain. Oxygenases oxidize hydrocarbons using dioxygen as the oxidant. As a Class I bacterial dioxygenases, benzoate dioxygenase like proteins combine an [2Fe-2S] cluster containing N-terminal...; Region: BenDO_FAD_NAD; cd06209 1100841004246 FAD binding pocket [chemical binding]; other site 1100841004247 FAD binding motif [chemical binding]; other site 1100841004248 phosphate binding motif [ion binding]; other site 1100841004249 beta-alpha-beta structure motif; other site 1100841004250 NAD binding pocket [chemical binding]; other site 1100841004251 Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667 1100841004252 inter-subunit interface; other site 1100841004253 benzoate 1,2-dioxygenase, large subunit; Region: benzo_1_2_benA; TIGR03229 1100841004254 Rieske non-heme iron oxygenase (RO) family, 2-Halobenzoate 1,2-dioxygenase (HBDO) subfamily, N-terminal Rieske domain of the oxygenase alpha subunit; ROs comprise a large class of aromatic ring-hydroxylating dioxygenases that enable microorganisms to...; Region: Rieske_RO_Alpha_HBDO; cd03542 1100841004255 C-terminal catalytic domain of the oxygenase alpha subunit of Pseudomonas resinovorans strain CA10 anthranilate 1,2-dioxygenase and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_AntDO-like; cd08879 1100841004256 putative alpha subunit interface [polypeptide binding]; other site 1100841004257 putative active site [active] 1100841004258 putative substrate binding site [chemical binding]; other site 1100841004259 Fe binding site [ion binding]; other site 1100841004260 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 1100841004261 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1100841004262 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in benzoate catabolism; contains the type 2 periplasmic binding fold; Region: PBP2_BenM_CatM_CatR; cd08445 1100841004263 dimerizarion interface [polypeptide binding]; other site 1100841004264 CrgA pocket; other site 1100841004265 substrate binding pocket [chemical binding]; other site 1100841004266 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1100841004267 metal-binding site [ion binding] 1100841004268 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1100841004269 metal-binding site [ion binding] 1100841004270 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1100841004271 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1100841004272 metal-binding site [ion binding] 1100841004273 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1100841004274 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1100841004275 motif II; other site 1100841004276 Cu(I)-responsive transcriptional regulator; Region: CueR; TIGR02044 1100841004277 Helix-Turn-Helix DNA binding domain of CueR-like transcription regulators; Region: HTH_CueR; cd01108 1100841004278 DNA binding residues [nucleotide binding] 1100841004279 dimer interface [polypeptide binding]; other site 1100841004280 copper binding site [ion binding]; other site 1100841004281 Glutathione-dependent formaldehyde-activating enzyme; Region: GFA; pfam04828 1100841004282 Cysteine-rich 4 helical bundle widely conserved in bacteria; Region: DUF326; cd08026 1100841004283 dimerization interface [polypeptide binding]; other site 1100841004284 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 1100841004285 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 1100841004286 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 1100841004287 generic binding surface II; other site 1100841004288 generic binding surface I; other site 1100841004289 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1100841004290 Predicted transcriptional regulator [Transcription]; Region: COG2932 1100841004291 non-specific DNA binding site [nucleotide binding]; other site 1100841004292 salt bridge; other site 1100841004293 sequence-specific DNA binding site [nucleotide binding]; other site 1100841004294 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1100841004295 Catalytic site [active] 1100841004296 Glycosyl hydrolase 108; Region: Glyco_hydro_108; pfam05838 1100841004297 Predicted Peptidoglycan domain; Region: PG_binding_3; pfam09374 1100841004298 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 1100841004299 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1100841004300 DNA-binding site [nucleotide binding]; DNA binding site 1100841004301 RNA-binding motif; other site 1100841004302 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 1100841004303 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 1100841004304 Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072 1100841004305 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1100841004306 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1100841004307 putative substrate translocation pore; other site 1100841004308 Predicted transcriptional regulators [Transcription]; Region: COG1733 1100841004309 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1100841004310 Domain of unknown function (DUF4142); Region: DUF4142; pfam13628 1100841004311 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 1100841004312 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 1100841004313 active site 1100841004314 HIGH motif; other site 1100841004315 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 1100841004316 KMSKS motif; other site 1100841004317 Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963 1100841004318 tRNA binding surface [nucleotide binding]; other site 1100841004319 anticodon binding site; other site 1100841004320 D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892 1100841004321 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 1100841004322 putative active site [active] 1100841004323 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 1100841004324 HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662 1100841004325 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1100841004326 active site 1100841004327 motif I; other site 1100841004328 motif II; other site 1100841004329 Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835 1100841004330 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3117; cl01200 1100841004331 lipopolysaccharide transport periplasmic protein LptA; Region: outer_YhbN_LptA; TIGR03002 1100841004332 OstA-like protein; Region: OstA; pfam03968 1100841004333 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 1100841004334 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 1100841004335 Walker A/P-loop; other site 1100841004336 ATP binding site [chemical binding]; other site 1100841004337 Q-loop/lid; other site 1100841004338 ABC transporter signature motif; other site 1100841004339 Walker B; other site 1100841004340 D-loop; other site 1100841004341 H-loop/switch region; other site 1100841004342 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 1100841004343 type I secretion system ATPase, LssB family; Region: type_I_sec_LssB; TIGR03375 1100841004344 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1100841004345 ATP-binding cassette domain of bacteriocin exporters, subfamily C; Region: ABCC_bacteriocin_exporters; cd03245 1100841004346 Walker A/P-loop; other site 1100841004347 ATP binding site [chemical binding]; other site 1100841004348 Q-loop/lid; other site 1100841004349 ABC transporter signature motif; other site 1100841004350 Walker B; other site 1100841004351 D-loop; other site 1100841004352 H-loop/switch region; other site 1100841004353 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 1100841004354 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1100841004355 HlyD family secretion protein; Region: HlyD_3; pfam13437 1100841004356 Uncharacterized conserved protein [Function unknown]; Region: COG1739 1100841004357 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 1100841004358 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 1100841004359 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 1100841004360 putative trimer interface [polypeptide binding]; other site 1100841004361 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 1100841004362 trimer interface [polypeptide binding]; other site 1100841004363 active site 1100841004364 substrate binding site [chemical binding]; other site 1100841004365 putative CoA binding site [chemical binding]; other site 1100841004366 CoA binding site [chemical binding]; other site 1100841004367 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1100841004368 Ligand Binding Site [chemical binding]; other site 1100841004369 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 1100841004370 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1100841004371 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3108 1100841004372 Ferredoxin [Energy production and conversion]; Region: COG1146 1100841004373 4Fe-4S binding domain; Region: Fer4; cl02805 1100841004374 Domain of unknown function (DUF3470); Region: DUF3470; pfam11953 1100841004375 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 1100841004376 MutS domain I; Region: MutS_I; pfam01624 1100841004377 MutS domain II; Region: MutS_II; pfam05188 1100841004378 MutS domain III; Region: MutS_III; pfam05192 1100841004379 MutS domain V; Region: MutS_V; pfam00488 1100841004380 Walker A/P-loop; other site 1100841004381 ATP binding site [chemical binding]; other site 1100841004382 Q-loop/lid; other site 1100841004383 ABC transporter signature motif; other site 1100841004384 Walker B; other site 1100841004385 D-loop; other site 1100841004386 H-loop/switch region; other site 1100841004387 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1100841004388 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 1100841004389 AsnC family; Region: AsnC_trans_reg; pfam01037 1100841004390 Threonine/homoserine efflux transporter [Amino acid transport and metabolism]; Region: rhtA; COG5006 1100841004391 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1100841004392 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 1100841004393 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 1100841004394 putative acyl-acceptor binding pocket; other site 1100841004395 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1100841004396 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1100841004397 benzoate transport; Region: 2A0115; TIGR00895 1100841004398 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1100841004399 putative substrate translocation pore; other site 1100841004400 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1100841004401 Uncharacterized protein conserved in bacteria (DUF2147); Region: DUF2147; pfam09917 1100841004402 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 1100841004403 Helix-Turn-Helix DNA binding domain of the transcription regulators NolA and AlbR; Region: HTH_NolA-AlbR; cd04788 1100841004404 DNA binding residues [nucleotide binding] 1100841004405 putative dimer interface [polypeptide binding]; other site 1100841004406 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 1100841004407 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 1100841004408 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1100841004409 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1100841004410 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 1100841004411 Coenzyme A binding pocket [chemical binding]; other site 1100841004412 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 1100841004413 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1100841004414 motif II; other site 1100841004415 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 1100841004416 Uncharacterized protein conserved in bacteria [Function unknown]; Region: VgrG; COG3501 1100841004417 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 1100841004418 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 1100841004419 Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296 1100841004420 Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; pfam10106 1100841004421 RHS Repeat; Region: RHS_repeat; pfam05593 1100841004422 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 1100841004423 RHS Repeat; Region: RHS_repeat; pfam05593 1100841004424 RHS Repeat; Region: RHS_repeat; pfam05593 1100841004425 RHS Repeat; Region: RHS_repeat; pfam05593 1100841004426 RHS Repeat; Region: RHS_repeat; pfam05593 1100841004427 RHS Repeat; Region: RHS_repeat; pfam05593 1100841004428 RHS protein; Region: RHS; pfam03527 1100841004429 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 1100841004430 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1100841004431 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1100841004432 dimerization interface [polypeptide binding]; other site 1100841004433 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 1100841004434 LamB/YcsF family of lactam utilization protein; Region: LamB_YcsF_like; cd10787 1100841004435 putative active site [active] 1100841004436 hypothetical protein; Provisional; Region: PRK05463 1100841004437 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 1100841004438 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049 1100841004439 Allophanate hydrolase subunit 2; Region: AHS2; pfam02626 1100841004440 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 1100841004441 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1100841004442 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1100841004443 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1100841004444 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1100841004445 carboxyltransferase (CT) interaction site; other site 1100841004446 biotinylation site [posttranslational modification]; other site 1100841004447 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 1100841004448 ClC sycA-like chloride channel proteins. This ClC family presents in bacteria, where it facilitates acid resistance in acidic soil. Mutation of this gene (sycA) in Rhizobium tropici CIAT899 causes serious deficiencies in nodule development, nodulation...; Region: ClC_sycA_like; cd03682 1100841004449 putative Cl- selectivity filter; other site 1100841004450 putative pore gating glutamate residue; other site 1100841004451 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 1100841004452 Sel1-like repeats; Region: SEL1; smart00671 1100841004453 Sel1-like repeats; Region: SEL1; smart00671 1100841004454 Sel1-like repeats; Region: SEL1; smart00671 1100841004455 Sel1-like repeats; Region: SEL1; smart00671 1100841004456 Sel1-like repeats; Region: SEL1; smart00671 1100841004457 Sel1-like repeats; Region: SEL1; smart00671 1100841004458 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1100841004459 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1100841004460 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 1100841004461 putative hydrophobic ligand binding site [chemical binding]; other site 1100841004462 protein interface [polypeptide binding]; other site 1100841004463 gate; other site 1100841004464 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 1100841004465 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1100841004466 NAD binding site [chemical binding]; other site 1100841004467 catalytic Zn binding site [ion binding]; other site 1100841004468 structural Zn binding site [ion binding]; other site 1100841004469 urea carboxylase-associated protein 1; Region: urea_degr_1; TIGR03424 1100841004470 urea carboxylase-associated protein 2; Region: urea_degr_2; TIGR03425 1100841004471 urea carboxylase-associated protein 1; Region: urea_degr_1; TIGR03424 1100841004472 Domain of unknown function (DUF1989); Region: DUF1989; pfam09347 1100841004473 urea carboxylase; Region: urea_carbox; TIGR02712 1100841004474 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1100841004475 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1100841004476 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1100841004477 Allophanate hydrolase subunit 2; Region: AHS2; smart00797 1100841004478 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896 1100841004479 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1100841004480 carboxyltransferase (CT) interaction site; other site 1100841004481 biotinylation site [posttranslational modification]; other site 1100841004482 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 1100841004483 Predicted transcriptional regulators [Transcription]; Region: COG1733 1100841004484 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1100841004485 NikR C terminal nickel binding domain; Region: NikR_C; pfam08753 1100841004486 Amidase; Region: Amidase; cl11426 1100841004487 ABC transporter periplasmic binding protein, urea carboxylase region; Region: ABC_peri_uca; TIGR03427 1100841004488 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1100841004489 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1100841004490 Walker A/P-loop; other site 1100841004491 ATP binding site [chemical binding]; other site 1100841004492 Q-loop/lid; other site 1100841004493 ABC transporter signature motif; other site 1100841004494 Walker B; other site 1100841004495 D-loop; other site 1100841004496 H-loop/switch region; other site 1100841004497 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1100841004498 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1100841004499 dimer interface [polypeptide binding]; other site 1100841004500 conserved gate region; other site 1100841004501 putative PBP binding loops; other site 1100841004502 ABC-ATPase subunit interface; other site 1100841004503 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4460 1100841004504 Protein of unknown function (DUF770); Region: DUF770; pfam05591 1100841004505 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3517; cl05484 1100841004506 Protein of unknown function (DUF877); Region: DUF877; pfam05943 1100841004507 Protein of unknown function (DUF796); Region: DUF796; pfam05638 1100841004508 type VI secretion system lysozyme-like protein; Region: VI_zyme; TIGR03357 1100841004509 Bacterial protein of unknown function (DUF879); Region: DUF879; cl15462 1100841004510 Protein of unknown function (DUF1305); Region: DUF1305; pfam06996 1100841004511 Type VI protein secretion system component VasK [Intracellular trafficking, secretion, and vesicular transport]; Region: IcmF; COG3523 1100841004512 Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761 1100841004513 Protein of unknown function (DUF1215); Region: DUF1215; pfam06744 1100841004514 Uncharacterized protein conserved in bacteria (DUF2094); Region: DUF2094; cl01611 1100841004515 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 1100841004516 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1100841004517 ligand binding site [chemical binding]; other site 1100841004518 PAAR motif; Region: PAAR_motif; pfam05488 1100841004519 type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345 1100841004520 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1100841004521 Walker A motif; other site 1100841004522 ATP binding site [chemical binding]; other site 1100841004523 Walker B motif; other site 1100841004524 arginine finger; other site 1100841004525 JNK_SAPK-associated protein-1; Region: Jnk-SapK_ap_N; pfam09744 1100841004526 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1100841004527 Walker A motif; other site 1100841004528 ATP binding site [chemical binding]; other site 1100841004529 Walker B motif; other site 1100841004530 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1100841004531 type VI secretion-associated protein, ImpA family; Region: VI_chp_8; TIGR03363 1100841004532 ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812 1100841004533 type VI secretion protein, VC_A0114 family; Region: VI_chp_4; TIGR03353 1100841004534 Bacterial protein of unknown function (DUF876); Region: DUF876; pfam05936 1100841004535 type IV / VI secretion system protein, DotU family; Region: IV_VI_DotU; TIGR03349 1100841004536 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 1100841004537 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_M15_4; pfam13539 1100841004538 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1100841004539 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1100841004540 LysR substrate binding domain; Region: LysR_substrate; pfam03466 1100841004541 dimerization interface [polypeptide binding]; other site 1100841004542 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 1100841004543 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1100841004544 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1100841004545 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 1100841004546 Cytidine and deoxycytidylate deaminase zinc-binding region. The family contains cytidine deaminases, nucleoside deaminases, deoxycytidylate deaminases and riboflavin deaminases. Also included are the apoBec family of mRNA editing enzymes. All members...; Region: cytidine_deaminase-like; cl00269 1100841004547 putative cyanate transporter; Provisional; Region: cynX; PRK09705 1100841004548 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1100841004549 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214 1100841004550 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 1100841004551 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1100841004552 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1100841004553 Coenzyme A binding pocket [chemical binding]; other site 1100841004554 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1636 1100841004555 Putative hemolysin [General function prediction only]; Region: Hlx; COG3042 1100841004556 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 1100841004557 Domain of unknown function (DUF333); Region: DUF333; pfam03891 1100841004558 Peptidase inhibitor I78 family; Region: Inhibitor_I78; pfam11720 1100841004559 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1100841004560 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 1100841004561 Alpha-Ketoglutaric Semialdehyde Dehydrogenase; Region: ALDH_KGSADH; cd07129 1100841004562 dimer interface [polypeptide binding]; other site 1100841004563 NADP binding site [chemical binding]; other site 1100841004564 catalytic residues [active] 1100841004565 amino acid transporter; Region: 2A0306; TIGR00909 1100841004566 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 1100841004567 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 1100841004568 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 1100841004569 bifunctional aldehyde dehydrogenase/enoyl-CoA hydratase; Provisional; Region: PRK11563 1100841004570 N-terminal domain of the monoamine oxidase C dehydratase; Region: ALDH_MaoC-N; cd07128 1100841004571 substrate binding site [chemical binding]; other site 1100841004572 dimer interface [polypeptide binding]; other site 1100841004573 NADP binding site [chemical binding]; other site 1100841004574 catalytic residues [active] 1100841004575 MaoC_C The C-terminal hot dog fold of the MaoC (monoamine oxidase C) dehydratase regulatory protein. Orthologs of MaoC include PaaZ [Escherichia coli] and PaaN [Pseudomonas putida], which are putative ring-opening enzymes involved in phenylacetic acid...; Region: MaoC_C; cd03452 1100841004576 substrate binding site [chemical binding]; other site 1100841004577 phenylacetate-CoA oxygenase subunit PaaA; Provisional; Region: paaA; PRK13778 1100841004578 phenylacetate-CoA oxygenase, PaaG subunit; Region: PA_CoA_Oxy1; TIGR02156 1100841004579 phenylacetate-CoA oxygenase subunit PaaB; Provisional; Region: paaB; PRK13781 1100841004580 Phenylacetic acid catabolic protein; Region: PaaA_PaaC; pfam05138 1100841004581 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 1100841004582 phenylacetate-CoA oxygenase, PaaJ subunit; Region: PA_CoA_Oxy4; TIGR02159 1100841004583 phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160 1100841004584 NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214 1100841004585 FAD binding pocket [chemical binding]; other site 1100841004586 FAD binding motif [chemical binding]; other site 1100841004587 phosphate binding motif [ion binding]; other site 1100841004588 beta-alpha-beta structure motif; other site 1100841004589 NAD(p) ribose binding residues [chemical binding]; other site 1100841004590 NAD binding pocket [chemical binding]; other site 1100841004591 NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site 1100841004592 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1100841004593 catalytic loop [active] 1100841004594 iron binding site [ion binding]; other site 1100841004595 enoyl-CoA hydratase-isomerase; Provisional; Region: PRK09674 1100841004596 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1100841004597 substrate binding site [chemical binding]; other site 1100841004598 oxyanion hole (OAH) forming residues; other site 1100841004599 trimer interface [polypeptide binding]; other site 1100841004600 enoyl-CoA hydratase; Provisional; Region: PRK08140 1100841004601 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1100841004602 substrate binding site [chemical binding]; other site 1100841004603 oxyanion hole (OAH) forming residues; other site 1100841004604 trimer interface [polypeptide binding]; other site 1100841004605 3-hydroxy-acyl-CoA dehydrogenase; Validated; Region: PRK08268 1100841004606 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1100841004607 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1100841004608 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1100841004609 beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050 1100841004610 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1100841004611 dimer interface [polypeptide binding]; other site 1100841004612 active site 1100841004613 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1100841004614 phenylacetate-CoA ligase; Region: PA_CoA_ligase; TIGR02155 1100841004615 acyl-activating enzyme (AAE) consensus motif; other site 1100841004616 AMP binding site [chemical binding]; other site 1100841004617 active site 1100841004618 CoA binding site [chemical binding]; other site 1100841004619 PaaX-like protein; Region: PaaX; pfam07848 1100841004620 phenylacetic acid degradation operon negative regulatory protein PaaX; Region: PaaX_trns_reg; TIGR02277 1100841004621 PaaX-like protein C-terminal domain; Region: PaaX_C; pfam08223 1100841004622 phenylacetic acid degradation protein PaaY; Region: PaaY; TIGR02287 1100841004623 paaY-like: This group is composed by uncharacterized proteins with similarity to the protein product of the E. coli paaY gene, which is part of the paa gene cluster responsible for phenylacetic acid degradation. Proteins in this group are expected to...; Region: LbH_paaY_like; cd04745 1100841004624 putative trimer interface [polypeptide binding]; other site 1100841004625 putative metal binding site [ion binding]; other site 1100841004626 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1100841004627 CoenzymeA binding site [chemical binding]; other site 1100841004628 subunit interaction site [polypeptide binding]; other site 1100841004629 PHB binding site; other site 1100841004630 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 1100841004631 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 1100841004632 putative active site [active] 1100841004633 putative NTP binding site [chemical binding]; other site 1100841004634 putative nucleic acid binding site [nucleotide binding]; other site 1100841004635 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1100841004636 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1100841004637 Catalase-like heme-binding proteins similar to the uncharacterized srpA; Region: srpA_like; cd08153 1100841004638 putative heme binding pocket [chemical binding]; other site 1100841004639 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 1100841004640 Uncharacterized conserved protein [Function unknown]; Region: COG5470 1100841004641 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1100841004642 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1100841004643 DNA-binding site [nucleotide binding]; DNA binding site 1100841004644 FCD domain; Region: FCD; cl11656 1100841004645 Amino acid synthesis; Region: AA_synth; pfam06684 1100841004646 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 1100841004647 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1100841004648 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 1100841004649 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1100841004650 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 1100841004651 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1100841004652 Uncharacterized Candidatus pelagibacter aldehyde dehydrogenase, DhaS-like; Region: ALDH_DhaS; cd07114 1100841004653 NAD(P) binding site [chemical binding]; other site 1100841004654 catalytic residues [active] 1100841004655 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 1100841004656 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 1100841004657 succinic semialdehyde dehydrogenase; Region: PLN02278 1100841004658 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 1100841004659 tetramerization interface [polypeptide binding]; other site 1100841004660 NAD(P) binding site [chemical binding]; other site 1100841004661 catalytic residues [active] 1100841004662 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 1100841004663 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1100841004664 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1100841004665 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_6; cd08475 1100841004666 putative effector binding pocket; other site 1100841004667 putative dimerization interface [polypeptide binding]; other site 1100841004668 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 1100841004669 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1100841004670 beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Region: pcaR_pcaU; TIGR02431 1100841004671 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 1100841004672 Bacterial transcriptional regulator; Region: IclR; pfam01614 1100841004673 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1100841004674 4-hydroxybenzoate 3-monooxygenase; Validated; Region: PRK08243 1100841004675 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1100841004676 transcriptional regulator protein; Region: phnR; TIGR03337 1100841004677 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1100841004678 DNA-binding site [nucleotide binding]; DNA binding site 1100841004679 UTRA domain; Region: UTRA; pfam07702 1100841004680 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1100841004681 ABC-type thiamine transport system, periplasmic component [Coenzyme metabolism]; Region: TbpA; COG4143 1100841004682 putative 2-aminoethylphosphonate ABC transporter, ATP-binding protein; Region: PhnT2; TIGR03265 1100841004683 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1100841004684 Walker A/P-loop; other site 1100841004685 ATP binding site [chemical binding]; other site 1100841004686 Q-loop/lid; other site 1100841004687 ABC transporter signature motif; other site 1100841004688 Walker B; other site 1100841004689 D-loop; other site 1100841004690 H-loop/switch region; other site 1100841004691 putative 2-aminoethylphosphonate ABC transporter, permease protein; Region: PhnU2; TIGR03262 1100841004692 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1100841004693 dimer interface [polypeptide binding]; other site 1100841004694 conserved gate region; other site 1100841004695 putative PBP binding loops; other site 1100841004696 ABC-ATPase subunit interface; other site 1100841004697 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1100841004698 dimer interface [polypeptide binding]; other site 1100841004699 conserved gate region; other site 1100841004700 putative PBP binding loops; other site 1100841004701 ABC-ATPase subunit interface; other site 1100841004702 FAD dependent oxidoreductase TIGR03364; Region: HpnW_proposed 1100841004703 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1100841004704 2-aminoethylphosphonate--pyruvate transaminase; Provisional; Region: PRK13479 1100841004705 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1100841004706 catalytic residue [active] 1100841004707 phosphonoacetaldehyde hydrolase; Provisional; Region: PRK13478 1100841004708 benzoate transport; Region: 2A0115; TIGR00895 1100841004709 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1100841004710 putative substrate translocation pore; other site 1100841004711 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1100841004712 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1100841004713 active site 1100841004714 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1100841004715 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1100841004716 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 1100841004717 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1100841004718 Bacterial transcriptional regulator; Region: IclR; pfam01614 1100841004719 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1100841004720 enoyl-CoA hydratase; Provisional; Region: PRK06688 1100841004721 substrate binding site [chemical binding]; other site 1100841004722 oxyanion hole (OAH) forming residues; other site 1100841004723 trimer interface [polypeptide binding]; other site 1100841004724 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 1100841004725 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 1100841004726 FMN binding site [chemical binding]; other site 1100841004727 substrate binding site [chemical binding]; other site 1100841004728 putative catalytic residue [active] 1100841004729 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1100841004730 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1100841004731 putative substrate translocation pore; other site 1100841004732 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 1100841004733 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1100841004734 Bacterial transcriptional regulator; Region: IclR; pfam01614 1100841004735 acetyl-CoA acetyltransferase; Provisional; Region: PRK08131 1100841004736 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1100841004737 dimer interface [polypeptide binding]; other site 1100841004738 active site 1100841004739 3-hydroxy-acyl-CoA dehydrogenase; Validated; Region: PRK08268 1100841004740 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1100841004741 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1100841004742 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1100841004743 3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826 1100841004744 classical (c) SDRs; Region: SDR_c; cd05233 1100841004745 NAD(P) binding site [chemical binding]; other site 1100841004746 active site 1100841004747 enoyl-CoA hydratase; Provisional; Region: PRK08138 1100841004748 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1100841004749 substrate binding site [chemical binding]; other site 1100841004750 oxyanion hole (OAH) forming residues; other site 1100841004751 trimer interface [polypeptide binding]; other site 1100841004752 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1100841004753 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1100841004754 active site 1100841004755 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1100841004756 benzoate transport; Region: 2A0115; TIGR00895 1100841004757 putative substrate translocation pore; other site 1100841004758 3-oxoacid CoA-transferase, A subunit; Region: pcaI_scoA_fam; TIGR02429 1100841004759 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 1100841004760 Maltoporin periplasmic N-terminal extension; Region: Sugarporin_N; pfam11471 1100841004761 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1100841004762 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1100841004763 putative substrate translocation pore; other site 1100841004764 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1100841004765 CoenzymeA binding site [chemical binding]; other site 1100841004766 subunit interaction site [polypeptide binding]; other site 1100841004767 PHB binding site; other site 1100841004768 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 1100841004769 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 1100841004770 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1100841004771 active site 1100841004772 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 1100841004773 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 1100841004774 indolepyruvate ferredoxin oxidoreductase; Validated; Region: PRK09193 1100841004775 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 1100841004776 dimer interface [polypeptide binding]; other site 1100841004777 PYR/PP interface [polypeptide binding]; other site 1100841004778 TPP binding site [chemical binding]; other site 1100841004779 substrate binding site [chemical binding]; other site 1100841004780 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 1100841004781 TPP-binding site [chemical binding]; other site 1100841004782 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 1100841004783 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1100841004784 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1100841004785 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1100841004786 putative effector binding pocket; other site 1100841004787 dimerization interface [polypeptide binding]; other site 1100841004788 Isopropylmalate/homocitrate/citramalate synthases [Amino acid transport and metabolism]; Region: LeuA; COG0119 1100841004789 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 1100841004790 active site 1100841004791 catalytic residues [active] 1100841004792 metal binding site [ion binding]; metal-binding site 1100841004793 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 1100841004794 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1100841004795 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1100841004796 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1100841004797 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1100841004798 carboxyltransferase (CT) interaction site; other site 1100841004799 biotinylation site [posttranslational modification]; other site 1100841004800 enoyl-CoA hydratase; Provisional; Region: PRK05995 1100841004801 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1100841004802 substrate binding site [chemical binding]; other site 1100841004803 oxyanion hole (OAH) forming residues; other site 1100841004804 trimer interface [polypeptide binding]; other site 1100841004805 3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820 1100841004806 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 1100841004807 isovaleryl-CoA dehydrogenase; Region: PLN02519 1100841004808 Isovaleryl-CoA dehydrogenase; Region: IVD; cd01156 1100841004809 substrate binding site [chemical binding]; other site 1100841004810 FAD binding site [chemical binding]; other site 1100841004811 catalytic base [active] 1100841004812 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1100841004813 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1100841004814 AMP-binding domain protein; Validated; Region: PRK08315 1100841004815 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1100841004816 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917 1100841004817 acyl-activating enzyme (AAE) consensus motif; other site 1100841004818 putative AMP binding site [chemical binding]; other site 1100841004819 putative active site [active] 1100841004820 putative CoA binding site [chemical binding]; other site 1100841004821 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1100841004822 S-adenosylmethionine binding site [chemical binding]; other site 1100841004823 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 1100841004824 SGNH_hydrolase subfamily, similar to the putative arylesterase/acylhydrolase from the rumen anaerobe Prevotella bryantii XynE. The P. bryantii XynE gene is located in a xylanase gene cluster. SGNH hydrolases are a diverse family of lipases and esterases; Region: XynE_like; cd01830 1100841004825 active site 1100841004826 catalytic triad [active] 1100841004827 oxyanion hole [active] 1100841004828 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1100841004829 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1100841004830 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1100841004831 putative effector binding pocket; other site 1100841004832 dimerization interface [polypeptide binding]; other site 1100841004833 The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia. This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775 1100841004834 Competence-damaged protein; Region: CinA; pfam02464 1100841004835 hydroperoxidase II; Provisional; Region: katE; PRK11249 1100841004836 Clade 2 of the heme-binding enzyme catalase; Region: catalase_clade_2; cd08155 1100841004837 tetramer interface [polypeptide binding]; other site 1100841004838 heme binding pocket [chemical binding]; other site 1100841004839 Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132 1100841004840 domain interactions; other site 1100841004841 short chain dehydrogenase; Provisional; Region: PRK06701 1100841004842 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 1100841004843 NAD binding site [chemical binding]; other site 1100841004844 metal binding site [ion binding]; metal-binding site 1100841004845 active site 1100841004846 Stress-induced bacterial acidophilic repeat motif; Region: KGG; pfam10685 1100841004847 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 1100841004848 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1100841004849 Catalytic site [active] 1100841004850 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 1100841004851 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1100841004852 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1100841004853 putative DNA binding site [nucleotide binding]; other site 1100841004854 putative Zn2+ binding site [ion binding]; other site 1100841004855 AsnC family; Region: AsnC_trans_reg; pfam01037 1100841004856 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 1100841004857 Na binding site [ion binding]; other site 1100841004858 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 1100841004859 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1100841004860 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1100841004861 dimer interface [polypeptide binding]; other site 1100841004862 phosphorylation site [posttranslational modification] 1100841004863 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1100841004864 ATP binding site [chemical binding]; other site 1100841004865 Mg2+ binding site [ion binding]; other site 1100841004866 G-X-G motif; other site 1100841004867 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1100841004868 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1100841004869 active site 1100841004870 phosphorylation site [posttranslational modification] 1100841004871 intermolecular recognition site; other site 1100841004872 dimerization interface [polypeptide binding]; other site 1100841004873 Response regulator receiver domain; Region: Response_reg; pfam00072 1100841004874 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1100841004875 active site 1100841004876 phosphorylation site [posttranslational modification] 1100841004877 intermolecular recognition site; other site 1100841004878 dimerization interface [polypeptide binding]; other site 1100841004879 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1100841004880 DNA binding residues [nucleotide binding] 1100841004881 dimerization interface [polypeptide binding]; other site 1100841004882 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1100841004883 Coenzyme A binding pocket [chemical binding]; other site 1100841004884 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1100841004885 dimer interface [polypeptide binding]; other site 1100841004886 conserved gate region; other site 1100841004887 putative PBP binding loops; other site 1100841004888 ABC-ATPase subunit interface; other site 1100841004889 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1100841004890 dimer interface [polypeptide binding]; other site 1100841004891 conserved gate region; other site 1100841004892 putative PBP binding loops; other site 1100841004893 ABC-ATPase subunit interface; other site 1100841004894 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1100841004895 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1100841004896 Walker A/P-loop; other site 1100841004897 ATP binding site [chemical binding]; other site 1100841004898 Q-loop/lid; other site 1100841004899 ABC transporter signature motif; other site 1100841004900 Walker B; other site 1100841004901 D-loop; other site 1100841004902 H-loop/switch region; other site 1100841004903 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 1100841004904 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1100841004905 substrate binding pocket [chemical binding]; other site 1100841004906 membrane-bound complex binding site; other site 1100841004907 hinge residues; other site 1100841004908 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 1100841004909 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1100841004910 substrate binding pocket [chemical binding]; other site 1100841004911 membrane-bound complex binding site; other site 1100841004912 hinge residues; other site 1100841004913 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1100841004914 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1100841004915 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1100841004916 putative effector binding pocket; other site 1100841004917 dimerization interface [polypeptide binding]; other site 1100841004918 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 1100841004919 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1100841004920 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 1100841004921 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1100841004922 catalytic residue [active] 1100841004923 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 1100841004924 trimer interface [polypeptide binding]; other site 1100841004925 active site 1100841004926 substrate binding site [chemical binding]; other site 1100841004927 CoA binding site [chemical binding]; other site 1100841004928 Member of the Rhodanese Homology Domain superfamily, subgroup 1. This CD includes the putative rhodanese-related sulfurtransferases of several uncharacterized proteins; Region: RHOD_1; cd01522 1100841004929 active site residue [active] 1100841004930 short chain dehydrogenase; Provisional; Region: PRK12937 1100841004931 tetrahydroxynaphthalene/trihydroxynaphthalene reductase-like, classical (c) SDRs; Region: THN_reductase-like_SDR_c; cd05362 1100841004932 NADP binding site [chemical binding]; other site 1100841004933 homodimer interface [polypeptide binding]; other site 1100841004934 active site 1100841004935 substrate binding site [chemical binding]; other site 1100841004936 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1100841004937 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1100841004938 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 1100841004939 putative effector binding pocket; other site 1100841004940 putative dimerization interface [polypeptide binding]; other site 1100841004941 putative S-transferase; Provisional; Region: PRK11752 1100841004942 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 1100841004943 C-terminal domain interface [polypeptide binding]; other site 1100841004944 GSH binding site (G-site) [chemical binding]; other site 1100841004945 dimer interface [polypeptide binding]; other site 1100841004946 C-terminal, alpha helical domain of Escherichia coli Yghu Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YghU_like; cd10292 1100841004947 dimer interface [polypeptide binding]; other site 1100841004948 N-terminal domain interface [polypeptide binding]; other site 1100841004949 active site 1100841004950 glutathione S-transferase; Provisional; Region: PRK15113 1100841004951 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 1100841004952 C-terminal domain interface [polypeptide binding]; other site 1100841004953 GSH binding site (G-site) [chemical binding]; other site 1100841004954 dimer interface [polypeptide binding]; other site 1100841004955 C-terminal, alpha helical domain of an unknown subfamily 4 of Glutathione S-transferases; Region: GST_C_4; cd03195 1100841004956 putative dimer interface [polypeptide binding]; other site 1100841004957 N-terminal domain interface [polypeptide binding]; other site 1100841004958 putative substrate binding pocket (H-site) [chemical binding]; other site 1100841004959 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1100841004960 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1100841004961 The C-terminal substrate binding domain of LysR-like transcriptional regulator CidR, contains the type 2 periplasmic binding fold; Region: PBP2_CidR; cd08438 1100841004962 putative dimerization interface [polypeptide binding]; other site 1100841004963 LrgA family; Region: LrgA; cl00608 1100841004964 Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346 1100841004965 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1100841004966 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1100841004967 DNA-binding site [nucleotide binding]; DNA binding site 1100841004968 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1100841004969 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1100841004970 homodimer interface [polypeptide binding]; other site 1100841004971 catalytic residue [active] 1100841004972 Transcriptional regulator [Transcription]; Region: PaiB; COG2808 1100841004973 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1100841004974 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1100841004975 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1100841004976 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1100841004977 putative substrate translocation pore; other site 1100841004978 malonate decarboxylase, alpha subunit; Region: mdcA; TIGR01110 1100841004979 triphosphoribosyl-dephospho-CoA synthase; Validated; Region: PRK01237 1100841004980 malonate decarboxylase subunit delta; Provisional; Region: PRK01220 1100841004981 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189 1100841004982 malonate decarboxylase, gamma subunit; Region: malonate_gamma; TIGR03134 1100841004983 phosphoribosyl-dephospho-CoA transferase; Provisional; Region: PRK01293 1100841004984 Phosphoribosyl-dephospho-CoA transferase MdcG; Region: MdcG; pfam10620 1100841004985 malonate decarboxylase, epsilon subunit; Region: malonate_mdcH; TIGR03131 1100841004986 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1100841004987 Malonate transporter MadL subunit; Region: MadL; cl04273 1100841004988 malonate transporter, MadM subunit; Region: malonate_madM; TIGR00808 1100841004989 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1100841004990 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1100841004991 The C-terminal substrate-binding domian of LysR-type transcriptional regulator MdcR, which involved in the malonate catabolism contains the type 2 periplasmic binding fold; Region: PBP2_MdcR; cd08416 1100841004992 putative dimerization interface [polypeptide binding]; other site 1100841004993 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1100841004994 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1100841004995 DNA-binding site [nucleotide binding]; DNA binding site 1100841004996 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1100841004997 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1100841004998 homodimer interface [polypeptide binding]; other site 1100841004999 catalytic residue [active] 1100841005000 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 1100841005001 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 1100841005002 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 1100841005003 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1100841005004 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 1100841005005 active site 1100841005006 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 1100841005007 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 1100841005008 active site 1100841005009 non-prolyl cis peptide bond; other site 1100841005010 D-galactonate transporter; Region: 2A0114; TIGR00893 1100841005011 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1100841005012 potential frameshift: common BLAST hit: gi|126641487|ref|YP_001084471.1| signal peptide 1100841005013 taurine ABC transporter, periplasmic binding protein; Region: taurine_ABC_bnd; TIGR01729 1100841005014 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1100841005015 substrate binding pocket [chemical binding]; other site 1100841005016 membrane-bound complex binding site; other site 1100841005017 hinge residues; other site 1100841005018 taurine transporter ATP-binding subunit; Provisional; Region: tauB; PRK11248 1100841005019 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1100841005020 Walker A/P-loop; other site 1100841005021 ATP binding site [chemical binding]; other site 1100841005022 Q-loop/lid; other site 1100841005023 ABC transporter signature motif; other site 1100841005024 Walker B; other site 1100841005025 D-loop; other site 1100841005026 H-loop/switch region; other site 1100841005027 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1100841005028 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1100841005029 dimer interface [polypeptide binding]; other site 1100841005030 conserved gate region; other site 1100841005031 putative PBP binding loops; other site 1100841005032 ABC-ATPase subunit interface; other site 1100841005033 taurine dioxygenase; Reviewed; Region: tauD; PRK09553 1100841005034 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 1100841005035 active site 1100841005036 iron coordination sites [ion binding]; other site 1100841005037 substrate binding pocket [chemical binding]; other site 1100841005038 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 1100841005039 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1100841005040 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 1100841005041 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 1100841005042 acyl-activating enzyme (AAE) consensus motif; other site 1100841005043 active site 1100841005044 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1100841005045 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 1100841005046 active site 1100841005047 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1100841005048 potential frameshift: common BLAST hit: gi|384141390|ref|YP_005524100.1| non-ribosomal peptide synthetase protein 1100841005049 Condensation domain; Region: Condensation; pfam00668 1100841005050 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1100841005051 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1100841005052 The adenylation domain of nonribosomal peptide synthetases (NRPS), including salinosporamide A polyketide synthase; Region: A_NRPS_Ta1_like; cd12116 1100841005053 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 1100841005054 acyl-activating enzyme (AAE) consensus motif; other site 1100841005055 AMP binding site [chemical binding]; other site 1100841005056 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1100841005057 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 1100841005058 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 1100841005059 hydrophobic ligand binding site; other site 1100841005060 Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033 1100841005061 Protein of unknown function (DUF1329); Region: DUF1329; pfam07044 1100841005062 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1100841005063 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 1100841005064 NAD(P) binding site [chemical binding]; other site 1100841005065 active site 1100841005066 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1100841005067 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 1100841005068 catalytic site [active] 1100841005069 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 1100841005070 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 1100841005071 Stress-induced morphogen (activity unknown) [Signal transduction mechanisms]; Region: BolA; COG0271 1100841005072 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433 1100841005073 DNA-directed DNA polymerase III (polc); Region: polc; TIGR00594 1100841005074 putative active site [active] 1100841005075 putative PHP Thumb interface [polypeptide binding]; other site 1100841005076 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 1100841005077 active site 1100841005078 homodimer interface [polypeptide binding]; other site 1100841005079 homotetramer interface [polypeptide binding]; other site 1100841005080 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1100841005081 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 1100841005082 aminotransferase AlaT; Validated; Region: PRK09265 1100841005083 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1100841005084 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1100841005085 homodimer interface [polypeptide binding]; other site 1100841005086 catalytic residue [active] 1100841005087 methionine sulfoxide reductase B; Provisional; Region: PRK00222 1100841005088 SelR domain; Region: SelR; pfam01641 1100841005089 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 1100841005090 catalytic residues [active] 1100841005091 dimer interface [polypeptide binding]; other site 1100841005092 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1100841005093 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1100841005094 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1100841005095 LysE type translocator; Region: LysE; cl00565 1100841005096 succinyldiaminopimelate transaminase; Provisional; Region: PRK09147 1100841005097 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1100841005098 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1100841005099 homodimer interface [polypeptide binding]; other site 1100841005100 catalytic residue [active] 1100841005101 PII uridylyl-transferase; Provisional; Region: glnD; PRK00275 1100841005102 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 1100841005103 metal binding triad; other site 1100841005104 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 1100841005105 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1100841005106 Zn2+ binding site [ion binding]; other site 1100841005107 Mg2+ binding site [ion binding]; other site 1100841005108 ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900 1100841005109 C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899 1100841005110 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 1100841005111 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1100841005112 ATP-grasp domain; Region: ATP-grasp; pfam02222 1100841005113 5-carboxymethyl-2-hydroxymuconate isomerase (CHMI) is a trimeric enzyme catalyzing the isomerization of the unsaturated ketone 5-(carboxymethyl)-2-hydroxymuconate to 5-(carboxymethyl)-2-oxo-3-hexene-1,6-dionate. This is one step in the...; Region: CHMI; cl01268 1100841005114 trimer interface [polypeptide binding]; other site 1100841005115 putative substrate binding pocket [chemical binding]; other site 1100841005116 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 1100841005117 active site 1 [active] 1100841005118 dimer interface [polypeptide binding]; other site 1100841005119 hexamer interface [polypeptide binding]; other site 1100841005120 active site 2 [active] 1100841005121 putative L-valine exporter; Provisional; Region: PRK10408 1100841005122 AzlC protein; Region: AzlC; cl00570 1100841005123 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1100841005124 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1100841005125 ligand binding site [chemical binding]; other site 1100841005126 flexible hinge region; other site 1100841005127 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1100841005128 putative switch regulator; other site 1100841005129 non-specific DNA interactions [nucleotide binding]; other site 1100841005130 DNA binding site [nucleotide binding] 1100841005131 sequence specific DNA binding site [nucleotide binding]; other site 1100841005132 putative cAMP binding site [chemical binding]; other site 1100841005133 Predicted membrane protein [Function unknown]; Region: COG4539 1100841005134 GTP-binding protein YchF; Reviewed; Region: PRK09601 1100841005135 YchF GTPase; Region: YchF; cd01900 1100841005136 G1 box; other site 1100841005137 GTP/Mg2+ binding site [chemical binding]; other site 1100841005138 Switch I region; other site 1100841005139 G2 box; other site 1100841005140 Switch II region; other site 1100841005141 G3 box; other site 1100841005142 G4 box; other site 1100841005143 G5 box; other site 1100841005144 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 1100841005145 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1100841005146 dimer interface [polypeptide binding]; other site 1100841005147 conserved gate region; other site 1100841005148 ABC-ATPase subunit interface; other site 1100841005149 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 1100841005150 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 1100841005151 Walker A/P-loop; other site 1100841005152 ATP binding site [chemical binding]; other site 1100841005153 Q-loop/lid; other site 1100841005154 ABC transporter signature motif; other site 1100841005155 Walker B; other site 1100841005156 D-loop; other site 1100841005157 H-loop/switch region; other site 1100841005158 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 1100841005159 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 1100841005160 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 1100841005161 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 1100841005162 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 1100841005163 active site 1100841005164 non-prolyl cis peptide bond; other site 1100841005165 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 1100841005166 Dibenzothiophene (DBT) desulfurization enzyme C; Region: DszC; cd01163 1100841005167 Flavin binding site [chemical binding]; other site 1100841005168 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 1100841005169 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1100841005170 active site 1100841005171 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 1100841005172 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 1100841005173 C-terminal domain interface [polypeptide binding]; other site 1100841005174 GSH binding site (G-site) [chemical binding]; other site 1100841005175 dimer interface [polypeptide binding]; other site 1100841005176 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 1100841005177 N-terminal domain interface [polypeptide binding]; other site 1100841005178 glutamate and aspartate transporter subunit; Provisional; Region: PRK10797 1100841005179 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1100841005180 substrate binding pocket [chemical binding]; other site 1100841005181 membrane-bound complex binding site; other site 1100841005182 hinge residues; other site 1100841005183 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1100841005184 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1100841005185 dimer interface [polypeptide binding]; other site 1100841005186 conserved gate region; other site 1100841005187 putative PBP binding loops; other site 1100841005188 ABC-ATPase subunit interface; other site 1100841005189 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1100841005190 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1100841005191 dimer interface [polypeptide binding]; other site 1100841005192 conserved gate region; other site 1100841005193 putative PBP binding loops; other site 1100841005194 ABC-ATPase subunit interface; other site 1100841005195 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1100841005196 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1100841005197 Walker A/P-loop; other site 1100841005198 ATP binding site [chemical binding]; other site 1100841005199 Q-loop/lid; other site 1100841005200 ABC transporter signature motif; other site 1100841005201 Walker B; other site 1100841005202 D-loop; other site 1100841005203 H-loop/switch region; other site 1100841005204 DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563 1100841005205 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1100841005206 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1100841005207 putative DNA binding site [nucleotide binding]; other site 1100841005208 putative Zn2+ binding site [ion binding]; other site 1100841005209 AsnC family; Region: AsnC_trans_reg; pfam01037 1100841005210 hypothetical protein; Validated; Region: PRK00110 1100841005211 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown ABO13168; Region: LPLAT_ABO13168-like; cd07988 1100841005212 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1100841005213 putative acyl-acceptor binding pocket; other site 1100841005214 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1100841005215 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1100841005216 Domain of unknown function (DUF4102); Region: DUF4102; pfam13356 1100841005217 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 1100841005218 active site 1100841005219 catalytic residues [active] 1100841005220 Int/Topo IB signature motif; other site 1100841005221 DNA binding site [nucleotide binding] 1100841005222 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1100841005223 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1100841005224 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1100841005225 dimerization interface [polypeptide binding]; other site 1100841005226 Predicted membrane protein [Function unknown]; Region: COG4125 1100841005227 Bacterial Transmembrane Pair family; Region: BTP; pfam05232 1100841005228 Bacterial Transmembrane Pair family; Region: BTP; pfam05232 1100841005229 Purine-cytosine permease and related proteins [Nucleotide transport and metabolism]; Region: CodB; COG1457 1100841005230 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 1100841005231 Na binding site [ion binding]; other site 1100841005232 EamA-like transporter family; Region: EamA; pfam00892 1100841005233 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1100841005234 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1100841005235 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1100841005236 dimerization interface [polypeptide binding]; other site 1100841005237 putative major fimbrial protein SthE; Provisional; Region: PRK15292 1100841005238 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 1100841005239 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 1100841005240 PapC N-terminal domain; Region: PapC_N; pfam13954 1100841005241 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 1100841005242 PapC C-terminal domain; Region: PapC_C; pfam13953 1100841005243 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 1100841005244 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 1100841005245 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 1100841005246 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 1100841005247 biotin synthase; Provisional; Region: PRK15108 1100841005248 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1100841005249 FeS/SAM binding site; other site 1100841005250 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 1100841005251 epoxyqueuosine reductase; Region: TIGR00276 1100841005252 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 1100841005253 putative carbohydrate kinase; Provisional; Region: PRK10565 1100841005254 YjeF-related protein N-terminus; Region: YjeF_N; pfam03853 1100841005255 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 1100841005256 putative substrate binding site [chemical binding]; other site 1100841005257 putative ATP binding site [chemical binding]; other site 1100841005258 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 1100841005259 active site 1100841005260 putative DNA-binding cleft [nucleotide binding]; other site 1100841005261 dimer interface [polypeptide binding]; other site 1100841005262 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1100841005263 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1100841005264 non-specific DNA binding site [nucleotide binding]; other site 1100841005265 salt bridge; other site 1100841005266 sequence-specific DNA binding site [nucleotide binding]; other site 1100841005267 Cupin domain; Region: Cupin_2; cl17218 1100841005268 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 1100841005269 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1100841005270 Beta-lactamase class D [Defense mechanisms]; Region: COG2602 1100841005271 FxsA cytoplasmic membrane protein; Region: FxsA; pfam04186 1100841005272 N2,N2-dimethylguanosine tRNA methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TRM1; COG1867 1100841005273 S-adenosylmethionine synthetase; Validated; Region: PRK05250 1100841005274 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 1100841005275 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 1100841005276 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 1100841005277 transketolase; Reviewed; Region: PRK12753 1100841005278 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 1100841005279 TPP-binding site [chemical binding]; other site 1100841005280 dimer interface [polypeptide binding]; other site 1100841005281 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 1100841005282 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1100841005283 PYR/PP interface [polypeptide binding]; other site 1100841005284 dimer interface [polypeptide binding]; other site 1100841005285 TPP binding site [chemical binding]; other site 1100841005286 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1100841005287 OsmC-like protein; Region: OsmC; pfam02566 1100841005288 Uncharacterized conserved protein [Function unknown]; Region: COG2353 1100841005289 Lecithin retinol acyltransferase; Region: LRAT; pfam04970 1100841005290 Predicted periplasmic protein [Function unknown]; Region: COG3698 1100841005291 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 1100841005292 tRNA (uracil-5-)-methyltransferase; Validated; Region: PRK05031 1100841005293 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1100841005294 S-adenosylmethionine binding site [chemical binding]; other site 1100841005295 Uncharacterized protein family (UPF0157); Region: UPF0157; cl00987 1100841005296 bifunctional proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: PRK11905 1100841005297 Proline dehydrogenase [Amino acid transport and metabolism]; Region: PutA; COG0506 1100841005298 Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125 1100841005299 Glutamate binding site [chemical binding]; other site 1100841005300 NAD binding site [chemical binding]; other site 1100841005301 catalytic residues [active] 1100841005302 leucine-responsive transcriptional regulator; Provisional; Region: PRK11169 1100841005303 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1100841005304 dimerization interface [polypeptide binding]; other site 1100841005305 putative DNA binding site [nucleotide binding]; other site 1100841005306 putative Zn2+ binding site [ion binding]; other site 1100841005307 AsnC family; Region: AsnC_trans_reg; pfam01037 1100841005308 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 1100841005309 Na binding site [ion binding]; other site 1100841005310 NAD-dependent deacetylase; Provisional; Region: PRK00481 1100841005311 SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412 1100841005312 NAD+ binding site [chemical binding]; other site 1100841005313 substrate binding site [chemical binding]; other site 1100841005314 Zn binding site [ion binding]; other site 1100841005315 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 1100841005316 lipoyl attachment site [posttranslational modification]; other site 1100841005317 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 1100841005318 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1100841005319 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1100841005320 YdeM is a Bacillus subtilis protein that belongs to a family of prokaryotic proteins of unkown function. YdeM has sequence similarity to the hot-dog fold of (R)-specific enoyl-CoA hydratase. Other enzymes with this fold include the peroxisomal...; Region: YdeM; cd03454 1100841005321 putative active site [active] 1100841005322 putative catalytic site [active] 1100841005323 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1100841005324 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1100841005325 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 1100841005326 Walker A/P-loop; other site 1100841005327 ATP binding site [chemical binding]; other site 1100841005328 Q-loop/lid; other site 1100841005329 ABC transporter signature motif; other site 1100841005330 Walker B; other site 1100841005331 D-loop; other site 1100841005332 H-loop/switch region; other site 1100841005333 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1100841005334 Uncharacterized protein conserved in bacteria (DUF2058); Region: DUF2058; pfam09831 1100841005335 Protein of unknown function (DUF1275); Region: DUF1275; pfam06912 1100841005336 serine/threonine transporter SstT; Provisional; Region: PRK13628 1100841005337 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1100841005338 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1100841005339 dimerization interface [polypeptide binding]; other site 1100841005340 putative DNA binding site [nucleotide binding]; other site 1100841005341 putative Zn2+ binding site [ion binding]; other site 1100841005342 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1100841005343 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1100841005344 Cupin superfamily protein; Region: Cupin_4; pfam08007 1100841005345 Cupin-like domain; Region: Cupin_8; pfam13621 1100841005346 Maf-like protein; Region: Maf; pfam02545 1100841005347 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 1100841005348 active site 1100841005349 dimer interface [polypeptide binding]; other site 1100841005350 Uncharacterized protein conserved in bacteria (DUF2237); Region: DUF2237; pfam09996 1100841005351 phosphoglycerate kinase; Provisional; Region: pgk; PRK00073 1100841005352 Phosphoglycerate kinase; Region: PGK; pfam00162 1100841005353 substrate binding site [chemical binding]; other site 1100841005354 hinge regions; other site 1100841005355 ADP binding site [chemical binding]; other site 1100841005356 catalytic site [active] 1100841005357 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 1100841005358 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 1100841005359 intersubunit interface [polypeptide binding]; other site 1100841005360 active site 1100841005361 zinc binding site [ion binding]; other site 1100841005362 Na+ binding site [ion binding]; other site 1100841005363 peptidyl-prolyl cis-trans isomerase SurA; Provisional; Region: PRK10770 1100841005364 SurA N-terminal domain; Region: SurA_N; pfam09312 1100841005365 PPIC-type PPIASE domain; Region: Rotamase_2; cl08278 1100841005366 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 1100841005367 Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452 1100841005368 OstA-like protein; Region: OstA; cl00844 1100841005369 Organic solvent tolerance protein; Region: OstA_C; pfam04453 1100841005370 Predicted phosphotransferase related to Ser/Thr protein kinases [General function prediction only]; Region: COG3178 1100841005371 Phosphotransferase enzyme family; Region: APH; pfam01636 1100841005372 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 1100841005373 NTP_transferase_like_1 is a member of the nucleotidyl transferase family; Region: NTP_transferase_like_1; cd06422 1100841005374 Substrate binding site; other site 1100841005375 metal-binding site 1100841005376 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 1100841005377 rRNA small subunit methyltransferase G; Region: GidB; pfam02527 1100841005378 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1100841005379 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1100841005380 P-loop; other site 1100841005381 Magnesium ion binding site [ion binding]; other site 1100841005382 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1100841005383 Magnesium ion binding site [ion binding]; other site 1100841005384 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 1100841005385 ParB-like nuclease domain; Region: ParB; smart00470 1100841005386 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 1100841005387 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 1100841005388 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 1100841005389 lipid A export permease/ATP-binding protein MsbA; Region: MsbA_lipidA; TIGR02203 1100841005390 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1100841005391 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 1100841005392 Walker A/P-loop; other site 1100841005393 ATP binding site [chemical binding]; other site 1100841005394 Q-loop/lid; other site 1100841005395 ABC transporter signature motif; other site 1100841005396 Walker B; other site 1100841005397 D-loop; other site 1100841005398 H-loop/switch region; other site 1100841005399 Tetraacyldisaccharide-1-P 4'-kinase [Cell envelope biogenesis, outer membrane]; Region: LpxK; COG1663 1100841005400 Tetraacyldisaccharide-1-P 4'-kinase; Region: LpxK; pfam02606 1100841005401 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 1100841005402 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 1100841005403 Ligand binding site; other site 1100841005404 oligomer interface; other site 1100841005405 DNA polymerase III subunit delta'; Validated; Region: PRK05707 1100841005406 PilZ domain; Region: PilZ; cl01260 1100841005407 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 1100841005408 active site 1100841005409 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1100841005410 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1100841005411 Type II secretion system (T2SS), protein I; Region: T2SI; pfam02501 1100841005412 type II secretion system protein J; Region: gspJ; TIGR01711 1100841005413 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 1100841005414 Type II secretion system (T2SS), protein J; Region: T2SJ; pfam11612 1100841005415 Type II secretion system (T2SS), protein K; Region: T2SK; pfam03934 1100841005416 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 1100841005417 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 1100841005418 ligand binding site [chemical binding]; other site 1100841005419 active site 1100841005420 UGI interface [polypeptide binding]; other site 1100841005421 catalytic site [active] 1100841005422 3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617 1100841005423 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1100841005424 substrate binding site [chemical binding]; other site 1100841005425 oxyanion hole (OAH) forming residues; other site 1100841005426 trimer interface [polypeptide binding]; other site 1100841005427 2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766 1100841005428 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 1100841005429 nucleoside/Zn binding site; other site 1100841005430 dimer interface [polypeptide binding]; other site 1100841005431 catalytic motif [active] 1100841005432 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 1100841005433 putative hydrophobic ligand binding site [chemical binding]; other site 1100841005434 protein interface [polypeptide binding]; other site 1100841005435 gate; other site 1100841005436 cytidylate kinase; Provisional; Region: cmk; PRK00023 1100841005437 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 1100841005438 CMP-binding site; other site 1100841005439 The sites determining sugar specificity; other site 1100841005440 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 1100841005441 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 1100841005442 RNA binding site [nucleotide binding]; other site 1100841005443 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 1100841005444 RNA binding site [nucleotide binding]; other site 1100841005445 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 1100841005446 RNA binding site [nucleotide binding]; other site 1100841005447 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1100841005448 RNA binding site [nucleotide binding]; other site 1100841005449 S1_RPS1_repeat_ec5: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec5; cd05690 1100841005450 RNA binding site [nucleotide binding]; other site 1100841005451 S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec6; cd05691 1100841005452 RNA binding site [nucleotide binding]; other site 1100841005453 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1100841005454 IHF dimer interface [polypeptide binding]; other site 1100841005455 IHF - DNA interface [nucleotide binding]; other site 1100841005456 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 1100841005457 active site 1100841005458 dimer interface [polypeptide binding]; other site 1100841005459 Membrane protein of unknown function (DUF340); Region: DUF340; cl01028 1100841005460 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1100841005461 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1100841005462 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 1100841005463 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1100841005464 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1100841005465 Predicted ATPase [General function prediction only]; Region: COG1485 1100841005466 malate synthase G; Provisional; Region: PRK02999 1100841005467 active site 1100841005468 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1100841005469 Coenzyme A binding pocket [chemical binding]; other site 1100841005470 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 1100841005471 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 1100841005472 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 1100841005473 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 1100841005474 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 1100841005475 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 1100841005476 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 1100841005477 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 1100841005478 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1100841005479 N-terminal plug; other site 1100841005480 ligand-binding site [chemical binding]; other site 1100841005481 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_18; cd08505 1100841005482 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 1100841005483 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_18; cd08505 1100841005484 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 1100841005485 Peptidase M3 Thimet oligopeptidase (TOP) also includes neurolysin; Region: M3A_TOP; cd06455 1100841005486 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 1100841005487 active site 1100841005488 Zn binding site [ion binding]; other site 1100841005489 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1100841005490 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1100841005491 dimer interface [polypeptide binding]; other site 1100841005492 conserved gate region; other site 1100841005493 putative PBP binding loops; other site 1100841005494 ABC-ATPase subunit interface; other site 1100841005495 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1100841005496 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1100841005497 dimer interface [polypeptide binding]; other site 1100841005498 conserved gate region; other site 1100841005499 putative PBP binding loops; other site 1100841005500 ABC-ATPase subunit interface; other site 1100841005501 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 1100841005502 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1100841005503 Walker A/P-loop; other site 1100841005504 ATP binding site [chemical binding]; other site 1100841005505 Q-loop/lid; other site 1100841005506 ABC transporter signature motif; other site 1100841005507 Walker B; other site 1100841005508 D-loop; other site 1100841005509 H-loop/switch region; other site 1100841005510 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1100841005511 Walker A/P-loop; other site 1100841005512 ATP binding site [chemical binding]; other site 1100841005513 Q-loop/lid; other site 1100841005514 ABC transporter signature motif; other site 1100841005515 Walker B; other site 1100841005516 D-loop; other site 1100841005517 H-loop/switch region; other site 1100841005518 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1100841005519 Uncharacterized ACR, COG2135; Region: DUF159; pfam02586 1100841005520 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1100841005521 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 1100841005522 active site 1100841005523 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1100841005524 catalytic core [active] 1100841005525 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 1100841005526 CC3(TIP30)-like, atypical (a) SDRs; Region: CC3_like_SDR_a; cd05250 1100841005527 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 1100841005528 NAD binding site [chemical binding]; other site 1100841005529 active site 1100841005530 ribonuclease activity regulator protein RraA; Provisional; Region: PRK09372 1100841005531 GST_N family, 2 repeats of the N-terminal domain of soluble GSTs (2 GST_N) subfamily; composed of uncharacterized proteins. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a...; Region: GST_N_2GST_N; cd03041 1100841005532 putative C-terminal domain interface [polypeptide binding]; other site 1100841005533 putative GSH binding site (G-site) [chemical binding]; other site 1100841005534 putative dimer interface [polypeptide binding]; other site 1100841005535 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 1100841005536 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1100841005537 Dyp-type peroxidase family; Region: Dyp_perox; cl01067 1100841005538 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 1100841005539 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 1100841005540 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1100841005541 ATP binding site [chemical binding]; other site 1100841005542 putative Mg++ binding site [ion binding]; other site 1100841005543 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1100841005544 nucleotide binding region [chemical binding]; other site 1100841005545 ATP-binding site [chemical binding]; other site 1100841005546 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 1100841005547 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 1100841005548 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1100841005549 cyclase homology domain; Region: CHD; cd07302 1100841005550 nucleotidyl binding site; other site 1100841005551 metal binding site [ion binding]; metal-binding site 1100841005552 dimer interface [polypeptide binding]; other site 1100841005553 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 1100841005554 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1100841005555 catalytic loop [active] 1100841005556 iron binding site [ion binding]; other site 1100841005557 chaperone protein HscA; Provisional; Region: hscA; PRK05183 1100841005558 Nucleotide-binding domain of HscA and similar proteins; Region: HscA_like_NBD; cd10236 1100841005559 nucleotide binding site [chemical binding]; other site 1100841005560 putative NEF/HSP70 interaction site [polypeptide binding]; other site 1100841005561 SBD interface [polypeptide binding]; other site 1100841005562 co-chaperone HscB; Provisional; Region: hscB; PRK05014 1100841005563 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1100841005564 HSP70 interaction site [polypeptide binding]; other site 1100841005565 HSCB C-terminal oligomerisation domain; Region: HSCB_C; pfam07743 1100841005566 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 1100841005567 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 1100841005568 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 1100841005569 trimerization site [polypeptide binding]; other site 1100841005570 active site 1100841005571 cysteine desulfurase; Provisional; Region: PRK14012 1100841005572 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 1100841005573 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1100841005574 catalytic residue [active] 1100841005575 Transcriptional regulator; Region: Rrf2; cl17282 1100841005576 Rrf2 family protein; Region: rrf2_super; TIGR00738 1100841005577 Poly(hydroxyalcanoate) granule associated protein (phasin); Region: Phasin; pfam05597 1100841005578 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1100841005579 IHF dimer interface [polypeptide binding]; other site 1100841005580 IHF - DNA interface [nucleotide binding]; other site 1100841005581 periplasmic folding chaperone; Provisional; Region: PRK10788 1100841005582 SurA N-terminal domain; Region: SurA_N_3; cl07813 1100841005583 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 1100841005584 Cupin; Region: Cupin_6; pfam12852 1100841005585 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1100841005586 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1100841005587 Alkane hydroxylase is a bacterial, integral-membrane di-iron enzyme that shares a requirement for iron and oxygen for activity similar to that of the non-heme integral-membrane acyl coenzyme A (CoA) desaturases and acyl lipid desaturases. The alk genes...; Region: Alkane-hydroxylase; cd03512 1100841005588 Fatty acid desaturase; Region: FA_desaturase; pfam00487 1100841005589 Di-iron ligands [ion binding]; other site 1100841005590 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1100841005591 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1100841005592 active site 1100841005593 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1100841005594 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1100841005595 active site 1100841005596 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 1100841005597 ABC1 family; Region: ABC1; cl17513 1100841005598 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 1100841005599 putative deacylase active site [active] 1100841005600 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 1100841005601 IucA / IucC family; Region: IucA_IucC; pfam04183 1100841005602 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 1100841005603 Lysine/ornithine N-monooxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: IucD; COG3486 1100841005604 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1100841005605 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1100841005606 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1100841005607 putative substrate translocation pore; other site 1100841005608 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1100841005609 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 1100841005610 IucA / IucC family; Region: IucA_IucC; pfam04183 1100841005611 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 1100841005612 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 1100841005613 IucA / IucC family; Region: IucA_IucC; pfam04183 1100841005614 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 1100841005615 FhuF 2Fe-2S C-terminal domain; Region: FhuF_C; pfam11575 1100841005616 Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480 1100841005617 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 1100841005618 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1100841005619 N-terminal plug; other site 1100841005620 ligand-binding site [chemical binding]; other site 1100841005621 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 1100841005622 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 1100841005623 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 1100841005624 Siderophore biosynthesis protein domain; Region: AlcB; smart01006 1100841005625 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 1100841005626 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1100841005627 motif II; other site 1100841005628 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 1100841005629 2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563 1100841005630 Cellular and retroviral pepsin-like aspartate proteases; Region: pepsin_retropepsin_like; cl11403 1100841005631 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 1100841005632 homotrimer interface [polypeptide binding]; other site 1100841005633 Walker A motif; other site 1100841005634 GTP binding site [chemical binding]; other site 1100841005635 Walker B motif; other site 1100841005636 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 1100841005637 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 1100841005638 putative dimer interface [polypeptide binding]; other site 1100841005639 active site pocket [active] 1100841005640 putative cataytic base [active] 1100841005641 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1100841005642 catalytic core [active] 1100841005643 Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061 1100841005644 cobalamin synthase; Reviewed; Region: cobS; PRK00235 1100841005645 phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261 1100841005646 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 1100841005647 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1100841005648 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 1100841005649 PepSY-associated TM helix; Region: PepSY_TM_3; pfam13706 1100841005650 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 1100841005651 Outer membrane receptor for ferric coprogen and ferric-rhodotorulic acid [Inorganic ion transport and metabolism]; Region: FhuE; COG4773 1100841005652 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1100841005653 N-terminal plug; other site 1100841005654 ligand-binding site [chemical binding]; other site 1100841005655 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 1100841005656 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 1100841005657 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1100841005658 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1100841005659 Domain of unknown function (DUF1956); Region: DUF1956; pfam09209 1100841005660 putative efflux pump membrane fusion protein; Provisional; Region: PRK03598 1100841005661 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1100841005662 HlyD family secretion protein; Region: HlyD_3; pfam13437 1100841005663 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1100841005664 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1100841005665 Walker A/P-loop; other site 1100841005666 ATP binding site [chemical binding]; other site 1100841005667 Q-loop/lid; other site 1100841005668 ABC transporter signature motif; other site 1100841005669 Walker B; other site 1100841005670 D-loop; other site 1100841005671 H-loop/switch region; other site 1100841005672 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 1100841005673 ATP-binding cassette domain of the lipid transporters, subfamily A; Region: ABC_subfamily_A; cd03263 1100841005674 Walker A/P-loop; other site 1100841005675 ATP binding site [chemical binding]; other site 1100841005676 Q-loop/lid; other site 1100841005677 ABC transporter signature motif; other site 1100841005678 Walker B; other site 1100841005679 D-loop; other site 1100841005680 H-loop/switch region; other site 1100841005681 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1100841005682 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 1100841005683 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1100841005684 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1100841005685 Protein of unknown function (DUF2797); Region: DUF2797; pfam10977 1100841005686 Bacterial protein of unknown function (DUF937); Region: DUF937; cl01528 1100841005687 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 1100841005688 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 1100841005689 eyelet of channel; other site 1100841005690 trimer interface [polypeptide binding]; other site 1100841005691 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 1100841005692 HIT family signature motif; other site 1100841005693 catalytic residue [active] 1100841005694 Uncharacterized conserved protein [Function unknown]; Region: COG3791 1100841005695 TonB C terminal; Region: TonB_2; pfam13103 1100841005696 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1100841005697 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1100841005698 S-adenosylmethionine binding site [chemical binding]; other site 1100841005699 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1100841005700 O-succinylhomoserine sulfhydrylase; Validated; Region: PRK08133 1100841005701 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1100841005702 homodimer interface [polypeptide binding]; other site 1100841005703 substrate-cofactor binding pocket; other site 1100841005704 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1100841005705 catalytic residue [active] 1100841005706 hypothetical protein; Validated; Region: PRK00153 1100841005707 recombination protein RecR; Reviewed; Region: recR; PRK00076 1100841005708 RecR protein; Region: RecR; pfam02132 1100841005709 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 1100841005710 putative active site [active] 1100841005711 putative metal-binding site [ion binding]; other site 1100841005712 tetramer interface [polypeptide binding]; other site 1100841005713 Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349 1100841005714 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 1100841005715 catalytic site [active] 1100841005716 putative active site [active] 1100841005717 putative substrate binding site [chemical binding]; other site 1100841005718 HRDC domain; Region: HRDC; pfam00570 1100841005719 YcgL domain; Region: YcgL; pfam05166 1100841005720 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1100841005721 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1100841005722 Walker A motif; other site 1100841005723 ATP binding site [chemical binding]; other site 1100841005724 Walker B motif; other site 1100841005725 arginine finger; other site 1100841005726 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3825 1100841005727 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 1100841005728 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 1100841005729 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1100841005730 catalytic residue [active] 1100841005731 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1100841005732 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1100841005733 S-adenosylmethionine binding site [chemical binding]; other site 1100841005734 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 1100841005735 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 1100841005736 Tetramer interface [polypeptide binding]; other site 1100841005737 active site 1100841005738 FMN-binding site [chemical binding]; other site 1100841005739 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1100841005740 metal binding site [ion binding]; metal-binding site 1100841005741 active site 1100841005742 I-site; other site 1100841005743 TENA/THI-4/PQQC family; Region: TENA_THI-4; cl15243 1100841005744 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 1100841005745 lipoyl synthase; Provisional; Region: PRK12928 1100841005746 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1100841005747 FeS/SAM binding site; other site 1100841005748 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182 1100841005749 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 1100841005750 tetramer interface [polypeptide binding]; other site 1100841005751 TPP-binding site [chemical binding]; other site 1100841005752 heterodimer interface [polypeptide binding]; other site 1100841005753 phosphorylation loop region [posttranslational modification] 1100841005754 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 1100841005755 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 1100841005756 alpha subunit interface [polypeptide binding]; other site 1100841005757 TPP binding site [chemical binding]; other site 1100841005758 heterodimer interface [polypeptide binding]; other site 1100841005759 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1100841005760 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1100841005761 pyruvate dehydrogenase complex dihydrolipoamide acetyltransferase, long form; Region: PDHac_trf_mito; TIGR01349 1100841005762 E3 interaction surface; other site 1100841005763 lipoyl attachment site [posttranslational modification]; other site 1100841005764 e3 binding domain; Region: E3_binding; pfam02817 1100841005765 e3 binding domain; Region: E3_binding; pfam02817 1100841005766 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1100841005767 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 1100841005768 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1100841005769 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1100841005770 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1100841005771 meso-2,3-butanediol dehydrogenase-like, classical (c) SDRs; Region: meso-BDH-like_SDR_c; cd05366 1100841005772 acetoin reductases; Region: 23BDH; TIGR02415 1100841005773 NAD binding site [chemical binding]; other site 1100841005774 homotetramer interface [polypeptide binding]; other site 1100841005775 homodimer interface [polypeptide binding]; other site 1100841005776 active site 1100841005777 substrate binding site [chemical binding]; other site 1100841005778 (2R,3R)-2,3-butanediol dehydrogenase; Region: butanediol_DH_like; cd08233 1100841005779 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1100841005780 putative NAD(P) binding site [chemical binding]; other site 1100841005781 catalytic Zn binding site [ion binding]; other site 1100841005782 Bestrophin, RFP-TM, chloride channel; Region: Bestrophin; pfam01062 1100841005783 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1100841005784 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 1100841005785 Walker A motif; other site 1100841005786 ATP binding site [chemical binding]; other site 1100841005787 Walker B motif; other site 1100841005788 arginine finger; other site 1100841005789 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1100841005790 Putative phosphatase (DUF442); Region: DUF442; cl17385 1100841005791 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 1100841005792 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1100841005793 Homoserine dehydrogenase [Amino acid transport and metabolism]; Region: ThrA; COG0460 1100841005794 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 1100841005795 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 1100841005796 EamA-like transporter family; Region: EamA; pfam00892 1100841005797 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 1100841005798 EamA-like transporter family; Region: EamA; pfam00892 1100841005799 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1100841005800 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1100841005801 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1100841005802 Predicted transcriptional regulators [Transcription]; Region: COG1733 1100841005803 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1100841005804 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 1100841005805 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1100841005806 Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059 1100841005807 chromate transporter, chromate ion transporter (CHR) family; Region: 2A51; TIGR00937 1100841005808 Chromate transporter; Region: Chromate_transp; pfam02417 1100841005809 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1100841005810 UTRA domain; Region: UTRA; pfam07702 1100841005811 putative oxidoreductase; Provisional; Region: PRK08275 1100841005812 L-aspartate oxidase; Provisional; Region: PRK06175 1100841005813 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1100841005814 Ferredoxin [Energy production and conversion]; Region: COG1146 1100841005815 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 1100841005816 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 1100841005817 substrate binding pocket [chemical binding]; other site 1100841005818 membrane-bound complex binding site; other site 1100841005819 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1100841005820 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1100841005821 dimer interface [polypeptide binding]; other site 1100841005822 conserved gate region; other site 1100841005823 putative PBP binding loops; other site 1100841005824 ABC-ATPase subunit interface; other site 1100841005825 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1100841005826 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1100841005827 Walker A/P-loop; other site 1100841005828 ATP binding site [chemical binding]; other site 1100841005829 Q-loop/lid; other site 1100841005830 ABC transporter signature motif; other site 1100841005831 Walker B; other site 1100841005832 D-loop; other site 1100841005833 H-loop/switch region; other site 1100841005834 HEAT repeats; Region: HEAT_2; pfam13646 1100841005835 HEAT repeats; Region: HEAT_2; pfam13646 1100841005836 HEAT repeats; Region: HEAT_2; pfam13646 1100841005837 Protein of unknown function (DUF971); Region: DUF971; pfam06155 1100841005838 alpha-ketoglutarate transporter; Provisional; Region: PRK10406 1100841005839 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1100841005840 putative substrate translocation pore; other site 1100841005841 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 1100841005842 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1100841005843 N-terminal plug; other site 1100841005844 ligand-binding site [chemical binding]; other site 1100841005845 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 1100841005846 Aspartase; Region: Aspartase; cd01357 1100841005847 active sites [active] 1100841005848 tetramer interface [polypeptide binding]; other site 1100841005849 cell density-dependent motility repressor; Provisional; Region: PRK10082 1100841005850 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1100841005851 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1100841005852 dimerization interface [polypeptide binding]; other site 1100841005853 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1100841005854 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1100841005855 The C-terminal substrate binding domain of LysR-type transcriptional regulators that are involved in the catabolism of dinitrotoluene, naphthalene and gamma-hexachlorohexane; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_NahR_LinR_like; cd08459 1100841005856 substrate binding pocket [chemical binding]; other site 1100841005857 dimerization interface [polypeptide binding]; other site 1100841005858 acetyl-CoA acetyltransferase; Provisional; Region: PRK06954 1100841005859 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1100841005860 dimer interface [polypeptide binding]; other site 1100841005861 active site 1100841005862 Short chain fatty acids transporter [Lipid metabolism]; Region: AtoE; COG2031 1100841005863 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 1100841005864 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 1100841005865 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1100841005866 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1100841005867 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 1100841005868 putative dimerization interface [polypeptide binding]; other site 1100841005869 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 1100841005870 fructuronate transporter; Provisional; Region: PRK10034; cl15264 1100841005871 3-hydroxybutyrate dehydrogenase; Provisional; Region: PRK12429 1100841005872 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1100841005873 NAD(P) binding site [chemical binding]; other site 1100841005874 active site 1100841005875 Helix-turn-helix domain; Region: HTH_18; pfam12833 1100841005876 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1100841005877 benzoate transport; Region: 2A0115; TIGR00895 1100841005878 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1100841005879 putative substrate translocation pore; other site 1100841005880 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1100841005881 Dienelactone hydrolase family; Region: DLH; pfam01738 1100841005882 SnoaL-like domain; Region: SnoaL_2; pfam12680 1100841005883 short chain dehydrogenase; Provisional; Region: PRK08265 1100841005884 classical (c) SDRs; Region: SDR_c; cd05233 1100841005885 NAD(P) binding site [chemical binding]; other site 1100841005886 active site 1100841005887 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 1100841005888 Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; cl01768 1100841005889 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1100841005890 Helix-turn-helix domain; Region: HTH_18; pfam12833 1100841005891 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1100841005892 anthranilate dioxygenase reductase; Provisional; Region: antC; PRK11872 1100841005893 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1100841005894 catalytic loop [active] 1100841005895 iron binding site [ion binding]; other site 1100841005896 Benzoate dioxygenase reductase (BenDO) FAD/NAD binding domain. Oxygenases oxidize hydrocarbons using dioxygen as the oxidant. As a Class I bacterial dioxygenases, benzoate dioxygenase like proteins combine an [2Fe-2S] cluster containing N-terminal...; Region: BenDO_FAD_NAD; cd06209 1100841005897 FAD binding pocket [chemical binding]; other site 1100841005898 FAD binding motif [chemical binding]; other site 1100841005899 phosphate binding motif [ion binding]; other site 1100841005900 beta-alpha-beta structure motif; other site 1100841005901 NAD binding pocket [chemical binding]; other site 1100841005902 Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667 1100841005903 inter-subunit interface; other site 1100841005904 anthranilate 1,2-dioxygenase, large subunit; Region: anthran_1_2_A; TIGR03228 1100841005905 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 1100841005906 [2Fe-2S] cluster binding site [ion binding]; other site 1100841005907 C-terminal catalytic domain of the oxygenase alpha subunit of Pseudomonas resinovorans strain CA10 anthranilate 1,2-dioxygenase and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_AntDO-like; cd08879 1100841005908 putative alpha subunit interface [polypeptide binding]; other site 1100841005909 putative active site [active] 1100841005910 putative substrate binding site [chemical binding]; other site 1100841005911 Fe binding site [ion binding]; other site 1100841005912 N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; cl17549 1100841005913 molybdate transporter periplasmic protein; Provisional; Region: modA; PRK10677 1100841005914 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1100841005915 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 1100841005916 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1100841005917 dimer interface [polypeptide binding]; other site 1100841005918 conserved gate region; other site 1100841005919 putative PBP binding loops; other site 1100841005920 ABC-ATPase subunit interface; other site 1100841005921 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1100841005922 phosphonate C-P lyase system protein PhnL; Region: CP_lyasePhnL; TIGR02324 1100841005923 Walker A/P-loop; other site 1100841005924 ATP binding site [chemical binding]; other site 1100841005925 Q-loop/lid; other site 1100841005926 ABC transporter signature motif; other site 1100841005927 Walker B; other site 1100841005928 D-loop; other site 1100841005929 H-loop/switch region; other site 1100841005930 2,3-dihydroxybenzoate-2,3-dehydrogenase; Validated; Region: PRK08220 1100841005931 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1100841005932 NAD(P) binding site [chemical binding]; other site 1100841005933 active site 1100841005934 Isochorismatase, also known as 2,3 dihydro-2,3 dihydroxybenzoate synthase, catalyses the conversion of isochorismate, in the presence of water, to 2,3-dihydroxybenzoate and pyruvate, via the hydrolysis of a vinyl ether, an uncommon reaction in biological...; Region: isochorismatase; cd01013 1100841005935 hydrophobic substrate binding pocket; other site 1100841005936 Isochorismatase family; Region: Isochorismatase; pfam00857 1100841005937 active site 1100841005938 conserved cis-peptide bond; other site 1100841005939 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cl17326 1100841005940 metal binding site 2 [ion binding]; metal-binding site 1100841005941 putative DNA binding helix; other site 1100841005942 metal binding site 1 [ion binding]; metal-binding site 1100841005943 dimer interface [polypeptide binding]; other site 1100841005944 structural Zn2+ binding site [ion binding]; other site 1100841005945 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 1100841005946 Bacillus subtilis YhcR endonuclease and related proteins, N-terminal metallophosphatase domain; Region: MPP_YhcR_N; cd07412 1100841005947 putative active site [active] 1100841005948 putative metal binding site [ion binding]; other site 1100841005949 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 1100841005950 polyphosphate kinase; Provisional; Region: PRK05443 1100841005951 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 1100841005952 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 1100841005953 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 1100841005954 putative active site [active] 1100841005955 catalytic site [active] 1100841005956 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 1100841005957 putative domain interface [polypeptide binding]; other site 1100841005958 putative active site [active] 1100841005959 catalytic site [active] 1100841005960 pyrroloquinoline quinone biosynthesis protein PqqB; Provisional; Region: PRK05184 1100841005961 coenzyme PQQ biosynthesis protein B; Region: PQQ_syn_pqqB; TIGR02108 1100841005962 pyrroloquinoline quinone biosynthesis protein PqqC; Provisional; Region: PRK05157 1100841005963 pyrroloquinoline quinone biosynthesis protein PqqD; Provisional; Region: PRK02079 1100841005964 pyrroloquinoline quinone biosynthesis protein PqqE; Provisional; Region: PRK05301 1100841005965 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1100841005966 FeS/SAM binding site; other site 1100841005967 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 1100841005968 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 1100841005969 renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301 1100841005970 active site 1100841005971 dimer interface [polypeptide binding]; other site 1100841005972 MUG-like Uracil-DNA glycosylase enzyme family; Region: UDG_MUG_like; cd10032 1100841005973 putative active site [active] 1100841005974 Putative catalytic domain, repeat 1, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_1; cd09111 1100841005975 PLD-like domain; Region: PLDc_2; pfam13091 1100841005976 putative active site [active] 1100841005977 catalytic site [active] 1100841005978 Putative catalytic domain, repeat 2, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_2; cd09113 1100841005979 PLD-like domain; Region: PLDc_2; pfam13091 1100841005980 putative active site [active] 1100841005981 catalytic site [active] 1100841005982 Catalase-like heme-binding proteins similar to the uncharacterized y4iL; Region: y4iL_like; cd08152 1100841005983 putative heme binding pocket [chemical binding]; other site 1100841005984 class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300 1100841005985 S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase; Region: adh_III_F_hyde; TIGR02818 1100841005986 substrate binding site [chemical binding]; other site 1100841005987 catalytic Zn binding site [ion binding]; other site 1100841005988 NAD binding site [chemical binding]; other site 1100841005989 structural Zn binding site [ion binding]; other site 1100841005990 dimer interface [polypeptide binding]; other site 1100841005991 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 1100841005992 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 1100841005993 PapC N-terminal domain; Region: PapC_N; pfam13954 1100841005994 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 1100841005995 PapC C-terminal domain; Region: PapC_C; pfam13953 1100841005996 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 1100841005997 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 1100841005998 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 1100841005999 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 1100841006000 Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; cl17479 1100841006001 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 1100841006002 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1100841006003 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1100841006004 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1100841006005 Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748 1100841006006 Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593 1100841006007 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1100841006008 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1100841006009 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1100841006010 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1100841006011 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1100841006012 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 1100841006013 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 1100841006014 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 1100841006015 Protein export membrane protein; Region: SecD_SecF; cl14618 1100841006016 Protein export membrane protein; Region: SecD_SecF; cl14618 1100841006017 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1100841006018 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1100841006019 HlyD family secretion protein; Region: HlyD_3; pfam13437 1100841006020 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1100841006021 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1100841006022 active site 1100841006023 phosphorylation site [posttranslational modification] 1100841006024 intermolecular recognition site; other site 1100841006025 dimerization interface [polypeptide binding]; other site 1100841006026 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1100841006027 DNA binding site [nucleotide binding] 1100841006028 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1100841006029 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1100841006030 dimerization interface [polypeptide binding]; other site 1100841006031 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1100841006032 dimer interface [polypeptide binding]; other site 1100841006033 phosphorylation site [posttranslational modification] 1100841006034 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1100841006035 ATP binding site [chemical binding]; other site 1100841006036 Mg2+ binding site [ion binding]; other site 1100841006037 G-X-G motif; other site 1100841006038 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 1100841006039 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 1100841006040 dimerization interface [polypeptide binding]; other site 1100841006041 putative DNA binding site [nucleotide binding]; other site 1100841006042 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1100841006043 putative Zn2+ binding site [ion binding]; other site 1100841006044 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1100841006045 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1100841006046 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 1100841006047 classical (c) SDRs; Region: SDR_c; cd05233 1100841006048 NAD(P) binding site [chemical binding]; other site 1100841006049 active site 1100841006050 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 1100841006051 classical (c) SDRs; Region: SDR_c; cd05233 1100841006052 NAD(P) binding site [chemical binding]; other site 1100841006053 active site 1100841006054 PAAR motif; Region: PAAR_motif; pfam05488 1100841006055 Phage antirepressor protein KilAC domain; Region: ANT; pfam03374 1100841006056 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1100841006057 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1100841006058 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1100841006059 non-specific DNA binding site [nucleotide binding]; other site 1100841006060 salt bridge; other site 1100841006061 sequence-specific DNA binding site [nucleotide binding]; other site 1100841006062 HD domain; Region: HD_4; pfam13328 1100841006063 Survival protein SurE; Region: SurE; pfam01975 1100841006064 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 1100841006065 GH3 auxin-responsive promoter; Region: GH3; pfam03321 1100841006066 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1100841006067 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1100841006068 putative substrate translocation pore; other site 1100841006069 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1100841006070 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 1100841006071 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1100841006072 HlyD family secretion protein; Region: HlyD_3; pfam13437 1100841006073 indole acetimide hydrolase; Validated; Region: PRK07488 1100841006074 Amidase; Region: Amidase; pfam01425 1100841006075 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1100841006076 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1100841006077 DNA binding residues [nucleotide binding] 1100841006078 dimerization interface [polypeptide binding]; other site 1100841006079 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cl00246 1100841006080 FAD binding site [chemical binding]; other site 1100841006081 Methylene-tetrahydrofolate reductase C terminal; Region: MTHFR_C; pfam12225 1100841006082 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 1100841006083 nudix motif; other site 1100841006084 Uncharacterized conserved protein [General function prediction only]; Region: COG4111 1100841006085 putative nicotinate phosphoribosyltransferase; Provisional; Region: PRK09198 1100841006086 pre-B-cell colony-enhancing factor (PBEF)-like. The mammalian members of this group of nicotinate phosphoribosyltransferases (NAPRTases) were originally identified as genes whose expression is upregulated upon activation in lymphoid cells. In general; Region: PBEF_like; cd01569 1100841006087 active site 1100841006088 Phosphoribosylpyrophosphate synthetase [Nucleotide transport and metabolism / Amino acid transport and metabolism]; Region: PrsA; COG0462 1100841006089 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 1100841006090 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1100841006091 active site 1100841006092 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1100841006093 Cupin domain; Region: Cupin_2; cl17218 1100841006094 Helix-turn-helix domain; Region: HTH_18; pfam12833 1100841006095 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1100841006096 Coenzyme A binding pocket [chemical binding]; other site 1100841006097 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1100841006098 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1100841006099 Walker A/P-loop; other site 1100841006100 ATP binding site [chemical binding]; other site 1100841006101 Q-loop/lid; other site 1100841006102 ABC transporter signature motif; other site 1100841006103 Walker B; other site 1100841006104 D-loop; other site 1100841006105 H-loop/switch region; other site 1100841006106 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1100841006107 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1100841006108 ABC-ATPase subunit interface; other site 1100841006109 dimer interface [polypeptide binding]; other site 1100841006110 putative PBP binding regions; other site 1100841006111 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 1100841006112 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1100841006113 intersubunit interface [polypeptide binding]; other site 1100841006114 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 1100841006115 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 1100841006116 putative NAD(P) binding site [chemical binding]; other site 1100841006117 putative substrate binding site [chemical binding]; other site 1100841006118 catalytic Zn binding site [ion binding]; other site 1100841006119 structural Zn binding site [ion binding]; other site 1100841006120 dimer interface [polypeptide binding]; other site 1100841006121 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 1100841006122 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 1100841006123 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 1100841006124 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 1100841006125 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1100841006126 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1100841006127 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1100841006128 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 1100841006129 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1100841006130 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 1100841006131 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1100841006132 putative substrate translocation pore; other site 1100841006133 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1100841006134 Escherichia coli Gne (a nucleoside-diphosphate-sugar 4-epimerase)-like, extended (e) SDRs; Region: Gne_like_SDR_e; cd05238 1100841006135 putative NAD(P) binding site [chemical binding]; other site 1100841006136 active site 1100841006137 putative substrate binding site [chemical binding]; other site 1100841006138 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1100841006139 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1100841006140 The C-terminal substrate binding domain of galactose-binding protein regulator contains the type 2 periplasmic binding fold; Region: PBP2_GbpR; cd08435 1100841006141 putative dimerization interface [polypeptide binding]; other site 1100841006142 Fumarylacetoacetate (FAA) hydrolase family protein [General function prediction only]; Region: COG3970 1100841006143 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 1100841006144 dihydroxy-acid dehydratase; Provisional; Region: PRK13017 1100841006145 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 1100841006146 Alpha-Ketoglutaric Semialdehyde Dehydrogenase; Region: ALDH_KGSADH; cd07129 1100841006147 dimer interface [polypeptide binding]; other site 1100841006148 NADP binding site [chemical binding]; other site 1100841006149 catalytic residues [active] 1100841006150 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1100841006151 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1100841006152 AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246 1100841006153 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1100841006154 putative substrate translocation pore; other site 1100841006155 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 1100841006156 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1100841006157 HlyD family secretion protein; Region: HlyD_3; pfam13437 1100841006158 RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931 1100841006159 type I secretion C-terminal target domain (VC_A0849 subclass); Region: T1SS_VCA0849; TIGR03661 1100841006160 hypothetical protein; Validated; Region: PRK06201 1100841006161 Demethylmenaquinone methyltransferase [Coenzyme metabolism]; Region: MenG; COG0684 1100841006162 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 1100841006163 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 1100841006164 ligand binding site [chemical binding]; other site 1100841006165 NAD binding site [chemical binding]; other site 1100841006166 dimerization interface [polypeptide binding]; other site 1100841006167 catalytic site [active] 1100841006168 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1100841006169 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1100841006170 putative substrate translocation pore; other site 1100841006171 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 1100841006172 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1100841006173 Bacterial transcriptional regulator; Region: IclR; pfam01614 1100841006174 Protein of unknown function, DUF606; Region: DUF606; pfam04657 1100841006175 Protein of unknown function, DUF606; Region: DUF606; pfam04657 1100841006176 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1100841006177 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1100841006178 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1100841006179 putative effector binding pocket; other site 1100841006180 dimerization interface [polypeptide binding]; other site 1100841006181 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1100841006182 putative substrate translocation pore; other site 1100841006183 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1100841006184 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 1100841006185 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 1100841006186 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1100841006187 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1100841006188 DNA-binding site [nucleotide binding]; DNA binding site 1100841006189 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 1100841006190 Dicarboxylate carrier protein MatC N-terminus; Region: MatC_N; pfam07158 1100841006191 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 1100841006192 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 1100841006193 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 1100841006194 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1100841006195 active site 1100841006196 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 1100841006197 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1100841006198 putative substrate translocation pore; other site 1100841006199 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1100841006200 haemagglutination activity domain; Region: Haemagg_act; pfam05860 1100841006201 Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; cl01733 1100841006202 Possible hemagglutinin (DUF637); Region: DUF637; pfam04830 1100841006203 Pre-toxin domain with VENN motif; Region: PT-VENN; pfam04829 1100841006204 MafB19-like deaminase; Region: MafB19-deam; pfam14437 1100841006205 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 1100841006206 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 1100841006207 Haemolysin secretion/activation protein ShlB/FhaC/HecB; Region: ShlB; pfam03865 1100841006208 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1100841006209 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1100841006210 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like2; cd05667 1100841006211 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1100841006212 metal binding site [ion binding]; metal-binding site 1100841006213 putative dimer interface [polypeptide binding]; other site 1100841006214 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 1100841006215 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 1100841006216 Kef-type K+ transport systems, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: Kch; COG1226 1100841006217 TrkA-N domain; Region: TrkA_N; pfam02254 1100841006218 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 1100841006219 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 1100841006220 LysR family transcriptional regulator; Provisional; Region: PRK14997 1100841006221 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1100841006222 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_4; cd08473 1100841006223 putative effector binding pocket; other site 1100841006224 putative dimerization interface [polypeptide binding]; other site 1100841006225 Isochorismatase family; Region: Isochorismatase; pfam00857 1100841006226 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 1100841006227 catalytic triad [active] 1100841006228 dimer interface [polypeptide binding]; other site 1100841006229 conserved cis-peptide bond; other site 1100841006230 Uncharacterized conserved protein [Function unknown]; Region: COG1359 1100841006231 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1100841006232 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1100841006233 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 1100841006234 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 1100841006235 Transcriptional regulator; Region: Rrf2; pfam02082 1100841006236 Rrf2 family protein; Region: rrf2_super; TIGR00738 1100841006237 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 1100841006238 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 1100841006239 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 1100841006240 potential catalytic triad [active] 1100841006241 conserved cys residue [active] 1100841006242 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 1100841006243 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1100841006244 DNA binding residues [nucleotide binding] 1100841006245 RibD C-terminal domain; Region: RibD_C; cl17279 1100841006246 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 1100841006247 Uncharacterized conserved protein [Function unknown]; Region: COG3268 1100841006248 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1100841006249 NAD(P) binding site [chemical binding]; other site 1100841006250 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1100841006251 Old yellow enzyme (OYE)-related FMN binding domain, group 2. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_2_FMN; cd04733 1100841006252 putative active site [active] 1100841006253 putative FMN binding site [chemical binding]; other site 1100841006254 putative substrate binding site [chemical binding]; other site 1100841006255 putative catalytic residue [active] 1100841006256 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1100841006257 MarR family; Region: MarR; pfam01047 1100841006258 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1100841006259 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1100841006260 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 1100841006261 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 1100841006262 potential catalytic triad [active] 1100841006263 conserved cys residue [active] 1100841006264 2-oxoglutarate dehydrogenase E2 component; Region: PLN02226 1100841006265 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 1100841006266 Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156 1100841006267 tetramer interface [polypeptide binding]; other site 1100841006268 heme binding pocket [chemical binding]; other site 1100841006269 NADPH binding site [chemical binding]; other site 1100841006270 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1100841006271 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1100841006272 Acetoacetate decarboxylase (ADC); Region: ADC; cl01919 1100841006273 aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381 1100841006274 Coniferyl aldehyde dehydrogenase-like; Region: ALDH_CALDH_CalB; cd07133 1100841006275 NAD(P) binding site [chemical binding]; other site 1100841006276 catalytic residues [active] 1100841006277 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 1100841006278 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 1100841006279 NAD(P) binding site [chemical binding]; other site 1100841006280 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 1100841006281 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 1100841006282 Na binding site [ion binding]; other site 1100841006283 Protein of unknown function, DUF485; Region: DUF485; pfam04341 1100841006284 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07008 1100841006285 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1100841006286 acyl-activating enzyme (AAE) consensus motif; other site 1100841006287 AMP binding site [chemical binding]; other site 1100841006288 active site 1100841006289 CoA binding site [chemical binding]; other site 1100841006290 Propionate catabolism activator; Region: PrpR_N; pfam06506 1100841006291 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 1100841006292 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1100841006293 Walker A motif; other site 1100841006294 ATP binding site [chemical binding]; other site 1100841006295 Walker B motif; other site 1100841006296 arginine finger; other site 1100841006297 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1100841006298 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1100841006299 classical (c) SDRs; Region: SDR_c; cd05233 1100841006300 NAD(P) binding site [chemical binding]; other site 1100841006301 active site 1100841006302 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1100841006303 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 1100841006304 active site 1100841006305 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1100841006306 catalytic core [active] 1100841006307 Phosphotransferase enzyme family; Region: APH; pfam01636 1100841006308 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 1100841006309 putative active site [active] 1100841006310 putative substrate binding site [chemical binding]; other site 1100841006311 ATP binding site [chemical binding]; other site 1100841006312 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 1100841006313 Alpha-Ketoglutaric Semialdehyde Dehydrogenase; Region: ALDH_KGSADH; cd07129 1100841006314 dimer interface [polypeptide binding]; other site 1100841006315 NADP binding site [chemical binding]; other site 1100841006316 catalytic residues [active] 1100841006317 Uncharacterized protein conserved in bacteria [Function unknown]; Region: GguC; COG3802 1100841006318 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 1100841006319 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 1100841006320 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1100841006321 putative substrate translocation pore; other site 1100841006322 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1100841006323 dihydroxy-acid dehydratase; Validated; Region: PRK06131 1100841006324 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1100841006325 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1100841006326 DNA-binding site [nucleotide binding]; DNA binding site 1100841006327 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 1100841006328 Bacterial protein of unknown function (Gcw_chp); Region: Gcw_chp; pfam09694 1100841006329 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 1100841006330 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1100841006331 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1100841006332 dimerization interface [polypeptide binding]; other site 1100841006333 muconate and chloromuconate cycloisomerases; Region: mucon_cyclo; TIGR02534 1100841006334 Muconate Lactonizing Enzyme (MLE), an homooctameric enzyme, catalyses the conversion of cis,cis-muconate (CCM) to muconolactone (ML) in the catechol branch of the beta-ketoadipate pathway. This pathway is used in soil microbes to breakdown lignin-derived...; Region: MLE; cd03318 1100841006335 octamer interface [polypeptide binding]; other site 1100841006336 active site 1100841006337 muconolactone delta-isomerase; Region: muco_delta; TIGR03221 1100841006338 catechol 1,2-dioxygenase, proteobacterial; Region: catechol_proteo; TIGR02439 1100841006339 Catechol 1,2 dioxygenase (1,2-CTD) catalyzes an intradiol cleavage reaction of catechol to form cis,cis-muconate. 1,2-CTDs is homodimers with one catalytic non-heme ferric ion per monomer. They belong to the aromatic dioxygenase family, a family of...; Region: 1,2-CTD; cd03460 1100841006340 dimer interface [polypeptide binding]; other site 1100841006341 active site 1100841006342 3-oxoacid CoA-transferase, A subunit; Region: pcaI_scoA_fam; TIGR02429 1100841006343 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 1100841006344 beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050 1100841006345 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1100841006346 dimer interface [polypeptide binding]; other site 1100841006347 active site 1100841006348 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 1100841006349 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 1100841006350 Protein related to penicillin acylase [General function prediction only]; Region: COG2366 1100841006351 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 1100841006352 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 1100841006353 active site 1100841006354 Escherichia coli NAD+-dependent phenylacetaldehyde dehydrogenase PadA-like; Region: ALDH_PADH_NahF; cd07113 1100841006355 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1100841006356 NAD(P) binding site [chemical binding]; other site 1100841006357 catalytic residues [active] 1100841006358 tyramine oxidase; Provisional; Region: tynA; PRK14696 1100841006359 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 1100841006360 Copper amine oxidase, N3 domain; Region: Cu_amine_oxidN3; pfam02728 1100841006361 Copper amine oxidase, enzyme domain; Region: Cu_amine_oxid; pfam01179 1100841006362 DNA-binding transcriptional activator FeaR; Provisional; Region: PRK09685 1100841006363 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1100841006364 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 1100841006365 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 1100841006366 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 1100841006367 FMN-binding pocket [chemical binding]; other site 1100841006368 flavin binding motif; other site 1100841006369 phosphate binding motif [ion binding]; other site 1100841006370 beta-alpha-beta structure motif; other site 1100841006371 NAD binding pocket [chemical binding]; other site 1100841006372 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1100841006373 catalytic loop [active] 1100841006374 iron binding site [ion binding]; other site 1100841006375 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 1100841006376 classical (c) SDRs; Region: SDR_c; cd05233 1100841006377 NAD(P) binding site [chemical binding]; other site 1100841006378 active site 1100841006379 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 1100841006380 benzoate 1,2-dioxygenase, large subunit; Region: benzo_1_2_benA; TIGR03229 1100841006381 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 1100841006382 [2Fe-2S] cluster binding site [ion binding]; other site 1100841006383 C-terminal catalytic domain of the oxygenase alpha subunit of Pseudomonas resinovorans strain CA10 anthranilate 1,2-dioxygenase and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_AntDO-like; cd08879 1100841006384 putative alpha subunit interface [polypeptide binding]; other site 1100841006385 putative active site [active] 1100841006386 putative substrate binding site [chemical binding]; other site 1100841006387 Fe binding site [ion binding]; other site 1100841006388 SnoaL-like domain; Region: SnoaL_4; pfam13577 1100841006389 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1100841006390 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1100841006391 active site 1100841006392 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 1100841006393 Amidase; Region: Amidase; cl11426 1100841006394 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1100841006395 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 1100841006396 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1100841006397 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1100841006398 putative substrate translocation pore; other site 1100841006399 outer membrane porin, OprD family; Region: OprD; pfam03573 1100841006400 short chain dehydrogenase; Provisional; Region: PRK08251 1100841006401 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1100841006402 NAD(P) binding site [chemical binding]; other site 1100841006403 active site 1100841006404 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 1100841006405 catalytic core [active] 1100841006406 thiamine kinase; Region: ycfN_thiK; TIGR02721 1100841006407 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 1100841006408 putative active site [active] 1100841006409 putative substrate binding site [chemical binding]; other site 1100841006410 ATP binding site [chemical binding]; other site 1100841006411 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1100841006412 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1100841006413 active site 1100841006414 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1100841006415 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1100841006416 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 1100841006417 substrate binding pocket [chemical binding]; other site 1100841006418 dimerization interface [polypeptide binding]; other site 1100841006419 beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Region: pcaR_pcaU; TIGR02431 1100841006420 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 1100841006421 Bacterial transcriptional regulator; Region: IclR; pfam01614 1100841006422 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 1100841006423 Predicted transporter component [General function prediction only]; Region: COG2391 1100841006424 Domain of unknown function (DUF4341); Region: DUF4341; pfam14241 1100841006425 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 1100841006426 membrane-bound PQQ-dependent dehydrogenase, glucose/quinate/shikimate family; Region: PQQ_membr_DH; TIGR03074 1100841006427 Membrane-bound PQQ-dependent glucose dehydrogenase; Region: PQQ_mGDH; cd10280 1100841006428 Trp docking motif [polypeptide binding]; other site 1100841006429 putative active site [active] 1100841006430 Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966 1100841006431 Right handed beta helix region; Region: Beta_helix; pfam13229 1100841006432 Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502 1100841006433 3-dehydroquinate dehydratase [Amino acid transport and metabolism]; Region: AroD; COG0710 1100841006434 active site 1100841006435 catalytic residue [active] 1100841006436 dimer interface [polypeptide binding]; other site 1100841006437 Protocatechuate 3,4-dioxygenase beta subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PcaH; COG3485 1100841006438 Protocatechuate 3,4-dioxygenase (3,4-PCD) , alpha subunit. 3,4-PCD catalyzes the oxidative ring cleavage of 3,4-dihydroxybenzoate to produce beta-carboxy-cis,cis-muconate. 3,4-PCDs are large aggregates of 12 protomers, each composed of an alpha- and...; Region: 3,4-PCD_alpha; cd03463 1100841006439 heterodimer interface [polypeptide binding]; other site 1100841006440 active site 1100841006441 Protocatechuate 3,4-dioxygenase (3,4-PCD) , beta subunit. 3,4-PCD catalyzes the oxidative ring cleavage of 3,4-dihydroxybenzoate to produce beta-carboxy-cis,cis-muconate. 3,4-PCDs are large aggregates of 12 protomers, each composed of an alpha- and...; Region: 3,4-PCD_beta; cd03464 1100841006442 heterodimer interface [polypeptide binding]; other site 1100841006443 multimer interface [polypeptide binding]; other site 1100841006444 protocatechuate 3,4-dioxygenase, beta subunit; Region: protocat_beta; TIGR02422 1100841006445 active site 1100841006446 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 1100841006447 benzoate transport; Region: 2A0115; TIGR00895 1100841006448 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1100841006449 putative substrate translocation pore; other site 1100841006450 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1100841006451 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1100841006452 3-carboxy-cis,cis-muconate cycloisomerase; Provisional; Region: PRK09053 1100841006453 prokaryotic 3-carboxy-cis,cis-muconate cycloisomerase (CMLE)_like; Region: pCLME; cd01597 1100841006454 tetramer interface [polypeptide binding]; other site 1100841006455 active site 1100841006456 beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050 1100841006457 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1100841006458 dimer interface [polypeptide binding]; other site 1100841006459 active site 1100841006460 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 1100841006461 3-oxoacid CoA-transferase, A subunit; Region: pcaI_scoA_fam; TIGR02429 1100841006462 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 1100841006463 substrate binding site; other site 1100841006464 dimer interface; other site 1100841006465 Septum formation initiator; Region: DivIC; cl17659 1100841006466 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 1100841006467 Predicted membrane protein [Function unknown]; Region: COG2323 1100841006468 enolase; Provisional; Region: eno; PRK00077 1100841006469 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 1100841006470 dimer interface [polypeptide binding]; other site 1100841006471 metal binding site [ion binding]; metal-binding site 1100841006472 substrate binding pocket [chemical binding]; other site 1100841006473 2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198 1100841006474 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 1100841006475 CTP synthetase; Validated; Region: pyrG; PRK05380 1100841006476 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 1100841006477 Catalytic site [active] 1100841006478 active site 1100841006479 UTP binding site [chemical binding]; other site 1100841006480 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 1100841006481 active site 1100841006482 putative oxyanion hole; other site 1100841006483 catalytic triad [active] 1100841006484 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687 1100841006485 Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118 1100841006486 Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; Region: COG0429 1100841006487 SGNH_hydrolase subfamily, FeeA, FeeB and similar esterases/lipases. FeeA and FeeB are part of a biosynthetic gene cluster and may participate in the biosynthesis of long-chain N-acyltyrosines by providing saturated and unsaturated fatty acids, which it...; Region: FeeA_FeeB_like; cd01836 1100841006488 active site 1100841006489 catalytic triad [active] 1100841006490 oxyanion hole [active] 1100841006491 SnoaL-like domain; Region: SnoaL_2; pfam12680 1100841006492 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1100841006493 2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930 1100841006494 active site 1100841006495 FMN binding site [chemical binding]; other site 1100841006496 2,4-decadienoyl-CoA binding site; other site 1100841006497 catalytic residue [active] 1100841006498 4Fe-4S cluster binding site [ion binding]; other site 1100841006499 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 1100841006500 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1100841006501 Predicted transcriptional regulators [Transcription]; Region: COG1695 1100841006502 Transcriptional regulator PadR-like family; Region: PadR; cl17335 1100841006503 Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400 1100841006504 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1100841006505 phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12755 1100841006506 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 1100841006507 hypothetical protein; Provisional; Region: PRK02237 1100841006508 ATP-dependent Clp protease ATP-binding subunit clpA; Region: ClpA; TIGR02639 1100841006509 Clp amino terminal domain; Region: Clp_N; pfam02861 1100841006510 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1100841006511 Walker A motif; other site 1100841006512 ATP binding site [chemical binding]; other site 1100841006513 Walker B motif; other site 1100841006514 arginine finger; other site 1100841006515 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1100841006516 Walker A motif; other site 1100841006517 ATP binding site [chemical binding]; other site 1100841006518 Walker B motif; other site 1100841006519 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1100841006520 Uncharacterized conserved protein [Function unknown]; Region: COG2127 1100841006521 Membrane-anchored protein predicted to be involved in regulation of amylopullulanase [Carbohydrate transport and metabolism]; Region: COG4945 1100841006522 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1100841006523 N-acetyl-gamma-glutamyl-phosphate reductase; Provisional; Region: PRK11863 1100841006524 Protein of unknown function DUF45; Region: DUF45; pfam01863 1100841006525 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 1100841006526 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1100841006527 active site 1100841006528 dimer interface [polypeptide binding]; other site 1100841006529 threonine dehydratase; Reviewed; Region: PRK09224 1100841006530 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 1100841006531 tetramer interface [polypeptide binding]; other site 1100841006532 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1100841006533 catalytic residue [active] 1100841006534 First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906 1100841006535 putative Ile/Val binding site [chemical binding]; other site 1100841006536 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 1100841006537 putative Ile/Val binding site [chemical binding]; other site 1100841006538 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 1100841006539 TrkA-N domain; Region: TrkA_N; pfam02254 1100841006540 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 1100841006541 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 1100841006542 The outer membrane phospholipase A (OMPLA) is an integral membrane enzyme that catalyses the hydrolysis of acylester bonds in phospholipids using calcium as a cofactor. The enzyme has a fold of transmembrane beta-barrels and is widespread among...; Region: OMPLA; cd00541 1100841006543 dimerization interface [polypeptide binding]; other site 1100841006544 substrate binding site [chemical binding]; other site 1100841006545 active site 1100841006546 calcium binding site [ion binding]; other site 1100841006547 Predicted Zn-dependent peptidases, insulinase-like [General function prediction only]; Region: COG1026 1100841006548 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 1100841006549 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1100841006550 Peptidase M16C associated; Region: M16C_assoc; pfam08367 1100841006551 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1100841006552 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 1100841006553 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1100841006554 N-terminal plug; other site 1100841006555 ligand-binding site [chemical binding]; other site 1100841006556 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1100841006557 Adenosine kinase (AK) catalyzes the phosphorylation of ribofuranosyl-containing nucleoside analogues at the 5'-hydroxyl using ATP or GTP as the phosphate donor.The physiological function of AK is associated with the regulation of extracellular...; Region: adenosine_kinase; cd01168 1100841006558 substrate binding site [chemical binding]; other site 1100841006559 ATP binding site [chemical binding]; other site 1100841006560 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 1100841006561 iron-sulfur cluster [ion binding]; other site 1100841006562 [2Fe-2S] cluster binding site [ion binding]; other site 1100841006563 Protein of unknown function (DUF1449); Region: DUF1449; pfam07290 1100841006564 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 1100841006565 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562 1100841006566 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 1100841006567 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 1100841006568 Membrane bound YbgT-like protein; Region: YbgT_YccB; pfam08173 1100841006569 Cyd operon protein YbgE (Cyd_oper_YbgE); Region: Cyd_oper_YbgE; pfam09600 1100841006570 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1100841006571 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1100841006572 Coenzyme A binding pocket [chemical binding]; other site 1100841006573 Uncharacterized protein conserved in bacteria (DUF2057); Region: DUF2057; pfam09829 1100841006574 Nitroreductase-like family 4. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_4; cd02140 1100841006575 dimer interface [polypeptide binding]; other site 1100841006576 FMN binding site [chemical binding]; other site 1100841006577 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 1100841006578 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 1100841006579 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 1100841006580 P loop; other site 1100841006581 GTP binding site [chemical binding]; other site 1100841006582 Protein of unknown function (DUF2750); Region: DUF2750; pfam11042 1100841006583 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_10; cd04623 1100841006584 FOG: CBS domain [General function prediction only]; Region: COG0517 1100841006585 acetylornithine aminotransferase; Provisional; Region: PRK02627 1100841006586 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1100841006587 inhibitor-cofactor binding pocket; inhibition site 1100841006588 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1100841006589 catalytic residue [active] 1100841006590 Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028 1100841006591 putative GSH binding site [chemical binding]; other site 1100841006592 catalytic residues [active] 1100841006593 LysR family transcriptional regulator; Provisional; Region: PRK14997 1100841006594 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1100841006595 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_4; cd08473 1100841006596 putative effector binding pocket; other site 1100841006597 putative dimerization interface [polypeptide binding]; other site 1100841006598 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 1100841006599 active site 1100841006600 Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547 1100841006601 Uncharacterized protein, possibly involved in utilization of glycolate and propanediol [General function prediction only]; Region: GlcG; COG3193 1100841006602 Predicted alpha/beta hydrolase [General function prediction only]; Region: COG4757 1100841006603 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1100841006604 bifunctional PTS system fructose-specific transporter subunit IIA/HPr protein; Provisional; Region: PRK11109 1100841006605 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1100841006606 active site 1100841006607 phosphorylation site [posttranslational modification] 1100841006608 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cl00163 1100841006609 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 1100841006610 dimerization domain swap beta strand [polypeptide binding]; other site 1100841006611 regulatory protein interface [polypeptide binding]; other site 1100841006612 active site 1100841006613 regulatory phosphorylation site [posttranslational modification]; other site 1100841006614 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 1100841006615 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 1100841006616 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1100841006617 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 1100841006618 potential frameshift: common BLAST hit: gi|184158382|ref|YP_001846721.1| fructose-1-phosphate kinase 1100841006619 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 1100841006620 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 1100841006621 ATP binding site [chemical binding]; other site 1100841006622 substrate binding site [chemical binding]; other site 1100841006623 PTS system fructose-specific transporter subunits IIBC; Provisional; Region: PRK10712 1100841006624 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 1100841006625 active site 1100841006626 P-loop; other site 1100841006627 phosphorylation site [posttranslational modification] 1100841006628 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; cl17425 1100841006629 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1100841006630 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1100841006631 putative DNA binding site [nucleotide binding]; other site 1100841006632 putative Zn2+ binding site [ion binding]; other site 1100841006633 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1100841006634 PAS domain; Region: PAS_9; pfam13426 1100841006635 putative active site [active] 1100841006636 heme pocket [chemical binding]; other site 1100841006637 PAS fold; Region: PAS_4; pfam08448 1100841006638 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 1100841006639 putative active site [active] 1100841006640 heme pocket [chemical binding]; other site 1100841006641 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1100841006642 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1100841006643 metal binding site [ion binding]; metal-binding site 1100841006644 active site 1100841006645 I-site; other site 1100841006646 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1100841006647 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1100841006648 Ligand Binding Site [chemical binding]; other site 1100841006649 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 1100841006650 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 1100841006651 Uncharacterized ACR, COG2135; Region: DUF159; pfam02586 1100841006652 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 1100841006653 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 1100841006654 Sulfate transporter family; Region: Sulfate_transp; pfam00916 1100841006655 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 1100841006656 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 1100841006657 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 1100841006658 Peptidase S8 family domain in ProteinaseK-like proteins; Region: Peptidases_S8_PCSK9_ProteinaseK_like; cd04077 1100841006659 calcium binding site 2 [ion binding]; other site 1100841006660 active site 1100841006661 catalytic triad [active] 1100841006662 calcium binding site 1 [ion binding]; other site 1100841006663 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1100841006664 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 1100841006665 Kynureninase [Amino acid transport and metabolism]; Region: COG3844 1100841006666 kynureninase; Region: kynureninase; TIGR01814 1100841006667 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1100841006668 catalytic residue [active] 1100841006669 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 1100841006670 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1100841006671 putative DNA binding site [nucleotide binding]; other site 1100841006672 putative Zn2+ binding site [ion binding]; other site 1100841006673 AsnC family; Region: AsnC_trans_reg; pfam01037 1100841006674 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1100841006675 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1100841006676 Fels-1 Prophage Protein-like; Region: Fels1; pfam05666 1100841006677 Fels-1 Prophage Protein-like; Region: Fels1; pfam05666 1100841006678 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 1100841006679 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 1100841006680 motif II; other site 1100841006681 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1100841006682 RNA binding surface [nucleotide binding]; other site 1100841006683 recombinase A; Provisional; Region: recA; PRK09354 1100841006684 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 1100841006685 hexamer interface [polypeptide binding]; other site 1100841006686 Walker A motif; other site 1100841006687 ATP binding site [chemical binding]; other site 1100841006688 Walker B motif; other site 1100841006689 recombination regulator RecX; Reviewed; Region: recX; PRK00117 1100841006690 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 1100841006691 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 1100841006692 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 1100841006693 active site 1100841006694 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 1100841006695 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 1100841006696 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 1100841006697 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 1100841006698 trimer interface [polypeptide binding]; other site 1100841006699 active site 1100841006700 UDP-GlcNAc binding site [chemical binding]; other site 1100841006701 lipid binding site [chemical binding]; lipid-binding site 1100841006702 Outer membrane protein (OmpH-like); Region: OmpH; pfam03938 1100841006703 outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303 1100841006704 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1100841006705 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1100841006706 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1100841006707 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1100841006708 Surface antigen; Region: Bac_surface_Ag; pfam01103 1100841006709 zinc metallopeptidase RseP; Provisional; Region: PRK10779 1100841006710 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 1100841006711 active site 1100841006712 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 1100841006713 protein binding site [polypeptide binding]; other site 1100841006714 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 1100841006715 protein binding site [polypeptide binding]; other site 1100841006716 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 1100841006717 putative substrate binding region [chemical binding]; other site 1100841006718 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 1100841006719 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 1100841006720 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 1100841006721 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 1100841006722 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 1100841006723 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 1100841006724 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 1100841006725 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 1100841006726 catalytic residue [active] 1100841006727 putative FPP diphosphate binding site; other site 1100841006728 putative FPP binding hydrophobic cleft; other site 1100841006729 dimer interface [polypeptide binding]; other site 1100841006730 putative IPP diphosphate binding site; other site 1100841006731 ribosome recycling factor; Reviewed; Region: frr; PRK00083 1100841006732 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 1100841006733 hinge region; other site 1100841006734 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 1100841006735 putative nucleotide binding site [chemical binding]; other site 1100841006736 uridine monophosphate binding site [chemical binding]; other site 1100841006737 homohexameric interface [polypeptide binding]; other site 1100841006738 ribosomal protein S12 methylthiotransferase; Provisional; Region: rimO; PRK14862 1100841006739 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 1100841006740 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1100841006741 FeS/SAM binding site; other site 1100841006742 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 1100841006743 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1100841006744 putative active site [active] 1100841006745 heme pocket [chemical binding]; other site 1100841006746 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1100841006747 dimer interface [polypeptide binding]; other site 1100841006748 phosphorylation site [posttranslational modification] 1100841006749 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1100841006750 ATP binding site [chemical binding]; other site 1100841006751 Mg2+ binding site [ion binding]; other site 1100841006752 G-X-G motif; other site 1100841006753 nitrogen regulation protein NR(I); Region: ntrC; TIGR01818 1100841006754 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1100841006755 active site 1100841006756 phosphorylation site [posttranslational modification] 1100841006757 intermolecular recognition site; other site 1100841006758 dimerization interface [polypeptide binding]; other site 1100841006759 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1100841006760 Walker A motif; other site 1100841006761 ATP binding site [chemical binding]; other site 1100841006762 Walker B motif; other site 1100841006763 arginine finger; other site 1100841006764 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1100841006765 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1100841006766 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1100841006767 ornithine carbamoyltransferase; Provisional; Region: PRK00779 1100841006768 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1100841006769 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1100841006770 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 1100841006771 catalytic residues [active] 1100841006772 active site 1100841006773 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 1100841006774 homotrimer interaction site [polypeptide binding]; other site 1100841006775 zinc binding site [ion binding]; other site 1100841006776 CDP-binding sites; other site 1100841006777 D-amino acid dehydrogenase small subunit; Provisional; Region: PRK12409 1100841006778 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1100841006779 hydroxyglutarate oxidase; Provisional; Region: PRK11728 1100841006780 fumarate hydratase; Reviewed; Region: fumC; PRK00485 1100841006781 Class II fumarases; Region: Fumarase_classII; cd01362 1100841006782 active site 1100841006783 tetramer interface [polypeptide binding]; other site 1100841006784 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 1100841006785 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1100841006786 NAD(P) binding site [chemical binding]; other site 1100841006787 active site 1100841006788 sulfur relay protein TusD/DsrE; Region: sulf_tusD_dsrE; TIGR03012 1100841006789 Dissimilatory sulfite reductase (desulfoviridin), gamma subunit [Inorganic ion transport and metabolism]; Region: DsrC; COG2920 1100841006790 DsrC like protein; Region: DsrC; pfam04358 1100841006791 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1100841006792 EamA-like transporter family; Region: EamA; pfam00892 1100841006793 EamA-like transporter family; Region: EamA; pfam00892 1100841006794 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1100841006795 DNA-binding site [nucleotide binding]; DNA binding site 1100841006796 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1100841006797 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1100841006798 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1100841006799 homodimer interface [polypeptide binding]; other site 1100841006800 catalytic residue [active] 1100841006801 Predicted transcriptional regulators [Transcription]; Region: COG1733 1100841006802 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1100841006803 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 1100841006804 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 1100841006805 dimer interface [polypeptide binding]; other site 1100841006806 putative functional site; other site 1100841006807 putative MPT binding site; other site 1100841006808 bifunctional molybdenum cofactor biosynthesis protein MoaC/MogA; Provisional; Region: moaC; PRK03604 1100841006809 MoaC family. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine derivative to the precursor...; Region: MoaC; cl00242 1100841006810 trimer interface [polypeptide binding]; other site 1100841006811 dimer interface [polypeptide binding]; other site 1100841006812 putative active site [active] 1100841006813 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 1100841006814 MPT binding site; other site 1100841006815 trimer interface [polypeptide binding]; other site 1100841006816 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 1100841006817 MoaE homodimer interface [polypeptide binding]; other site 1100841006818 MoaD interaction [polypeptide binding]; other site 1100841006819 active site residues [active] 1100841006820 molybdenum cofactor biosynthesis protein A, bacterial; Region: moaA; TIGR02666 1100841006821 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1100841006822 FeS/SAM binding site; other site 1100841006823 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 1100841006824 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 1100841006825 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1100841006826 molybdopterin cofactor binding site; other site 1100841006827 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1100841006828 The MopB_CT_1 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. This CD is of the...; Region: MopB_CT_1; cd02782 1100841006829 putative molybdopterin cofactor binding site; other site 1100841006830 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 1100841006831 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 1100841006832 GTP binding site; other site 1100841006833 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 1100841006834 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 1100841006835 [4Fe-4S] binding site [ion binding]; other site 1100841006836 molybdopterin cofactor binding site; other site 1100841006837 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 1100841006838 molybdopterin cofactor binding site; other site 1100841006839 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 1100841006840 Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529 1100841006841 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 1100841006842 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1100841006843 potential frameshift: common BLAST hit: gi|387123602|ref|YP_006289484.1| NAD(P)H-dependent nitrite reductase, large subunit 1100841006844 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1100841006845 Nitrite and sulphite reductase 4Fe-4S domain; Region: NIR_SIR; pfam01077 1100841006846 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 1100841006847 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1100841006848 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1100841006849 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 1100841006850 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 1100841006851 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1100841006852 active site 1100841006853 phosphorylation site [posttranslational modification] 1100841006854 intermolecular recognition site; other site 1100841006855 dimerization interface [polypeptide binding]; other site 1100841006856 ANTAR domain; Region: ANTAR; pfam03861 1100841006857 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 1100841006858 NMT1-like family; Region: NMT1_2; pfam13379 1100841006859 DNA polymerase V subunit UmuC; Reviewed; Region: umuC; PRK03609 1100841006860 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 1100841006861 active site 1100841006862 DNA binding site [nucleotide binding] 1100841006863 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 1100841006864 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 1100841006865 Dehydroquinase class II; Region: DHquinase_II; pfam01220 1100841006866 trimer interface [polypeptide binding]; other site 1100841006867 active site 1100841006868 dimer interface [polypeptide binding]; other site 1100841006869 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 1100841006870 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1100841006871 carboxyltransferase (CT) interaction site; other site 1100841006872 biotinylation site [posttranslational modification]; other site 1100841006873 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 1100841006874 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1100841006875 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1100841006876 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1100841006877 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1100841006878 putative 3-phenylpropionic acid transporter; Provisional; Region: PRK11128 1100841006879 putative substrate translocation pore; other site 1100841006880 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1100841006881 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1100841006882 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 1100841006883 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 1100841006884 Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069 1100841006885 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 1100841006886 active site 1100841006887 FMN binding site [chemical binding]; other site 1100841006888 substrate binding site [chemical binding]; other site 1100841006889 3Fe-4S cluster binding site [ion binding]; other site 1100841006890 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 1100841006891 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1100841006892 Uncharacterized conserved protein [Function unknown]; Region: COG1434 1100841006893 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 1100841006894 putative active site [active] 1100841006895 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK00046 1100841006896 FAD binding domain; Region: FAD_binding_4; pfam01565 1100841006897 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 1100841006898 Low molecular weight phosphatase family; Region: LMWPc; cd00115 1100841006899 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 1100841006900 active site 1100841006901 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 1100841006902 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 1100841006903 5-hydroxyvalerate dehydrogenase (HVD) catalyzes the oxidation of 5-hydroxyvalerate to 5-oxovalerate with NAD+ as cofactor; Region: HVD; cd08193 1100841006904 putative active site [active] 1100841006905 metal binding site [ion binding]; metal-binding site 1100841006906 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1100841006907 active site 1100841006908 phospholipase C, phosphocholine-specific, Pseudomonas-type; Region: PC_PLC; TIGR03396 1100841006909 Phosphoesterase family; Region: Phosphoesterase; pfam04185 1100841006910 Domain of unknown function (DUF756); Region: DUF756; pfam05506 1100841006911 Domain of unknown function (DUF756); Region: DUF756; pfam05506 1100841006912 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14960 1100841006913 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1100841006914 Walker A motif; other site 1100841006915 ATP binding site [chemical binding]; other site 1100841006916 Walker B motif; other site 1100841006917 arginine finger; other site 1100841006918 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 1100841006919 methyl viologen resistance protein SmvA; Provisional; Region: PRK14995 1100841006920 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1100841006921 putative substrate translocation pore; other site 1100841006922 TetR family transcriptional regulator; Provisional; Region: PRK14996 1100841006923 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1100841006924 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1100841006925 Beta-lactamase; Region: Beta-lactamase; pfam00144 1100841006926 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1100841006927 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1100841006928 active site 2 [active] 1100841006929 active site 1 [active] 1100841006930 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08261 1100841006931 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1100841006932 NAD(P) binding site [chemical binding]; other site 1100841006933 active site 1100841006934 acetyl-CoA acetyltransferase; Provisional; Region: PRK09268 1100841006935 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1100841006936 dimer interface [polypeptide binding]; other site 1100841006937 active site 1100841006938 Bacterial Transmembrane Pair family; Region: BTP; pfam05232 1100841006939 Bacterial Transmembrane Pair family; Region: BTP; pfam05232 1100841006940 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1100841006941 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1100841006942 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1100841006943 dimerization interface [polypeptide binding]; other site 1100841006944 transaldolase-like protein; Provisional; Region: PTZ00411 1100841006945 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 1100841006946 active site 1100841006947 dimer interface [polypeptide binding]; other site 1100841006948 catalytic residue [active] 1100841006949 leucine export protein LeuE; Provisional; Region: PRK10958 1100841006950 leucine-responsive transcriptional regulator; Provisional; Region: PRK11169 1100841006951 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 1100841006952 AsnC family; Region: AsnC_trans_reg; pfam01037 1100841006953 Benzoate membrane transport protein; Region: BenE; pfam03594 1100841006954 benzoate transporter; Region: benE; TIGR00843 1100841006955 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 1100841006956 MgtC family; Region: MgtC; pfam02308 1100841006957 magnesium-transporting ATPase MgtA; Provisional; Region: PRK10517 1100841006958 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 1100841006959 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1100841006960 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 1100841006961 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 1100841006962 RDD family; Region: RDD; pfam06271 1100841006963 dipeptidase, putative; Region: dipeptidaselike; TIGR01887 1100841006964 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1100841006965 Ligand Binding Site [chemical binding]; other site 1100841006966 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1100841006967 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1100841006968 Walker A/P-loop; other site 1100841006969 ATP binding site [chemical binding]; other site 1100841006970 Q-loop/lid; other site 1100841006971 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1100841006972 ABC transporter signature motif; other site 1100841006973 Walker B; other site 1100841006974 D-loop; other site 1100841006975 ABC transporter; Region: ABC_tran_2; pfam12848 1100841006976 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1100841006977 Outer membrane protein W [Cell envelope biogenesis, outer membrane]; Region: OmpW; COG3047 1100841006978 Outer membrane receptor for ferric coprogen and ferric-rhodotorulic acid [Inorganic ion transport and metabolism]; Region: FhuE; COG4773 1100841006979 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1100841006980 N-terminal plug; other site 1100841006981 ligand-binding site [chemical binding]; other site 1100841006982 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1100841006983 Coenzyme A binding pocket [chemical binding]; other site 1100841006984 synaptic vesicle protein SV2; Region: synapt_SV2; TIGR01299 1100841006985 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1100841006986 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1100841006987 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 1100841006988 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1100841006989 N-terminal plug; other site 1100841006990 ligand-binding site [chemical binding]; other site 1100841006991 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1100841006992 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1100841006993 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1100841006994 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1100841006995 putative DNA binding site [nucleotide binding]; other site 1100841006996 putative Zn2+ binding site [ion binding]; other site 1100841006997 AsnC family; Region: AsnC_trans_reg; pfam01037 1100841006998 chorismate mutase; Provisional; Region: PRK08055 1100841006999 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1100841007000 active site 1100841007001 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1100841007002 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 1100841007003 NAD(P) binding site [chemical binding]; other site 1100841007004 active site 1100841007005 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 1100841007006 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 1100841007007 C-terminal domain interface [polypeptide binding]; other site 1100841007008 GSH binding site (G-site) [chemical binding]; other site 1100841007009 dimer interface [polypeptide binding]; other site 1100841007010 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299 1100841007011 N-terminal domain interface [polypeptide binding]; other site 1100841007012 aminopeptidase N; Provisional; Region: pepN; PRK14015 1100841007013 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_1; cd09600 1100841007014 active site 1100841007015 Zn binding site [ion binding]; other site 1100841007016 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 1100841007017 substrate binding site [chemical binding]; other site 1100841007018 multimerization interface [polypeptide binding]; other site 1100841007019 ATP binding site [chemical binding]; other site 1100841007020 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1100841007021 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1100841007022 DNA gyrase inhibitor [DNA replication, recombination, and repair]; Region: COG3449 1100841007023 5-carboxymethyl-2-hydroxymuconate isomerase (CHMI) is a trimeric enzyme catalyzing the isomerization of the unsaturated ketone 5-(carboxymethyl)-2-hydroxymuconate to 5-(carboxymethyl)-2-oxo-3-hexene-1,6-dionate. This is one step in the...; Region: CHMI; cd00580 1100841007024 putative substrate binding pocket [chemical binding]; other site 1100841007025 trimer interface [polypeptide binding]; other site 1100841007026 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1100841007027 PIF1-like helicase; Region: PIF1; pfam05970 1100841007028 Walker A motif; other site 1100841007029 ATP binding site [chemical binding]; other site 1100841007030 Walker B motif; other site 1100841007031 Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176 1100841007032 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 1100841007033 dimer interface [polypeptide binding]; other site 1100841007034 active site 1100841007035 metal binding site [ion binding]; metal-binding site 1100841007036 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1100841007037 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1100841007038 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 1100841007039 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1100841007040 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1100841007041 NAD(P) binding site [chemical binding]; other site 1100841007042 catalytic residues [active] 1100841007043 ethanolamine permease; Region: 2A0305; TIGR00908 1100841007044 ethanolamine ammonia lyase large subunit; Provisional; Region: PRK15067 1100841007045 Ethanolamine ammonia lyase large subunit (EutB); Region: EutB; pfam06751 1100841007046 ethanolamine ammonia-lyase small subunit; Provisional; Region: PRK05465 1100841007047 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 1100841007048 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 1100841007049 catalytic triad [active] 1100841007050 glutaminyl-tRNA synthetase; Provisional; Region: PRK05347 1100841007051 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1100841007052 active site 1100841007053 HIGH motif; other site 1100841007054 nucleotide binding site [chemical binding]; other site 1100841007055 catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807 1100841007056 KMSKS motif; other site 1100841007057 tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950 1100841007058 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 1100841007059 substrate binding site [chemical binding]; other site 1100841007060 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1100841007061 NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149 1100841007062 dimer interface [polypeptide binding]; other site 1100841007063 FMN binding site [chemical binding]; other site 1100841007064 EamA-like transporter family; Region: EamA; pfam00892 1100841007065 phosphonate utilization associated putative membrane protein; Region: phn_DUF6; TIGR03340 1100841007066 bacterial Hfq-like; Region: Hfq; cd01716 1100841007067 hexamer interface [polypeptide binding]; other site 1100841007068 Sm1 motif; other site 1100841007069 RNA binding site [nucleotide binding]; other site 1100841007070 Sm2 motif; other site 1100841007071 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 1100841007072 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 1100841007073 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 1100841007074 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1100841007075 ATP binding site [chemical binding]; other site 1100841007076 Mg2+ binding site [ion binding]; other site 1100841007077 G-X-G motif; other site 1100841007078 MutL_Trans_MutL: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to Escherichia coli MutL. EcMutL belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second...; Region: MutL_Trans_MutL; cd03482 1100841007079 ATP binding site [chemical binding]; other site 1100841007080 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 1100841007081 Uncharacterized P-loop hydrolase UPF0079; Region: UPF0079; cl00520 1100841007082 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1100841007083 Pseudouridine synthase, a subgroup of the RluA family; Region: PSRA_1; cd02558 1100841007084 probable active site [active] 1100841007085 RelB antitoxin; Region: RelB; cl01171 1100841007086 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1100841007087 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1100841007088 Coenzyme A binding pocket [chemical binding]; other site 1100841007089 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 1100841007090 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1100841007091 RNA binding surface [nucleotide binding]; other site 1100841007092 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 1100841007093 active site 1100841007094 uracil binding [chemical binding]; other site 1100841007095 Protein of unknown function (DUF441); Region: DUF441; pfam04284 1100841007096 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1100841007097 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1100841007098 The C-terminal substrate binding domain of LysR-type transcriptional regulator metR, which regulates the expression of methionine biosynthetic genes, contains type 2 periplasmic binding fold; Region: PBP2_MetR; cd08441 1100841007099 putative dimerization interface [polypeptide binding]; other site 1100841007100 Domain of unknown function (DUF4198); Region: DUF4198; pfam10670 1100841007101 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1100841007102 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1100841007103 putative substrate translocation pore; other site 1100841007104 Ion transport protein; Region: Ion_trans; pfam00520 1100841007105 Ion channel; Region: Ion_trans_2; pfam07885 1100841007106 CCC1-related family of proteins; Region: CCC1_like; cl00278 1100841007107 Aconitase B swivel domain. Aconitate hydratase B is involved in energy metabolism as part of the TCA cycle. It catalyses the formation of cis-aconitate from citrate. This is the aconitase swivel domain, which undergoes swivelling conformational change in...; Region: AcnB_Swivel; cd01576 1100841007108 substrate binding site [chemical binding]; other site 1100841007109 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 1100841007110 Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle; Region: AcnB; cd01581 1100841007111 substrate binding site [chemical binding]; other site 1100841007112 ligand binding site [chemical binding]; other site 1100841007113 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911 1100841007114 Family of unknown function (DUF490); Region: DUF490; pfam04357 1100841007115 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1100841007116 Membrane-fusion protein [Cell envelope biogenesis, outer membrane]; Region: AcrA; COG0845 1100841007117 Surface antigen; Region: Bac_surface_Ag; pfam01103 1100841007118 lysophospholipid transporter LplT; Provisional; Region: PRK11195 1100841007119 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1100841007120 putative substrate translocation pore; other site 1100841007121 Demethoxyubiquinone hydroxylase, ferritin-like diiron-binding domain; Region: DMQH; cd01042 1100841007122 diiron binding motif [ion binding]; other site 1100841007123 Protein of unknown function (DUF2799); Region: DUF2799; pfam10973 1100841007124 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1100841007125 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 1100841007126 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1100841007127 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1100841007128 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1100841007129 active site 1100841007130 phosphorylation site [posttranslational modification] 1100841007131 intermolecular recognition site; other site 1100841007132 dimerization interface [polypeptide binding]; other site 1100841007133 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1100841007134 DNA binding site [nucleotide binding] 1100841007135 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 1100841007136 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 1100841007137 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 1100841007138 Ligand Binding Site [chemical binding]; other site 1100841007139 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1100841007140 dimer interface [polypeptide binding]; other site 1100841007141 phosphorylation site [posttranslational modification] 1100841007142 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1100841007143 ATP binding site [chemical binding]; other site 1100841007144 Mg2+ binding site [ion binding]; other site 1100841007145 G-X-G motif; other site 1100841007146 potassium-transporting ATPase subunit C; Reviewed; Region: PRK00315 1100841007147 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 1100841007148 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1100841007149 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1100841007150 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 1100841007151 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cl00233 1100841007152 catalytic center binding site [active] 1100841007153 ATP binding site [chemical binding]; other site 1100841007154 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 1100841007155 homooctamer interface [polypeptide binding]; other site 1100841007156 active site 1100841007157 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 1100841007158 ABC1 family; Region: ABC1; cl17513 1100841007159 molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690 1100841007160 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 1100841007161 ATP binding site [chemical binding]; other site 1100841007162 substrate interface [chemical binding]; other site 1100841007163 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 1100841007164 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 1100841007165 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1100841007166 acyl-activating enzyme (AAE) consensus motif; other site 1100841007167 AMP binding site [chemical binding]; other site 1100841007168 active site 1100841007169 CoA binding site [chemical binding]; other site 1100841007170 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1100841007171 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1100841007172 active site 1100841007173 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08217 1100841007174 17hydroxysteroid dehydrogenase type 10 (HSD10)-like, classical (c) SDRs; Region: HSD10-like_SDR_c; cd05371 1100841007175 NAD binding site [chemical binding]; other site 1100841007176 homodimer interface [polypeptide binding]; other site 1100841007177 homotetramer interface [polypeptide binding]; other site 1100841007178 active site 1100841007179 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 1100841007180 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1100841007181 SurA N-terminal domain; Region: SurA_N; pfam09312 1100841007182 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1100841007183 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 1100841007184 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1100841007185 substrate binding pocket [chemical binding]; other site 1100841007186 ABC transporter periplasmic binding protein, urea carboxylase region; Region: ABC_peri_uca; TIGR03427 1100841007187 membrane-bound complex binding site; other site 1100841007188 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1100841007189 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1100841007190 ABC-ATPase subunit interface; other site 1100841007191 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 1100841007192 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1100841007193 peptide chain release factor 1; Validated; Region: prfA; PRK00591 1100841007194 This domain is found in peptide chain release factors; Region: PCRF; smart00937 1100841007195 RF-1 domain; Region: RF-1; pfam00472 1100841007196 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 1100841007197 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 1100841007198 potential catalytic triad [active] 1100841007199 conserved cys residue [active] 1100841007200 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1100841007201 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1100841007202 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1100841007203 putative effector binding pocket; other site 1100841007204 dimerization interface [polypeptide binding]; other site 1100841007205 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 1100841007206 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 1100841007207 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1100841007208 PgaD-like protein; Region: PgaD; pfam13994 1100841007209 N-glycosyltransferase; Provisional; Region: PRK11204 1100841007210 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 1100841007211 DXD motif; other site 1100841007212 poly-beta-1,6-N-acetyl-D-glucosamine N-deacetylase PgaB; Region: deacetyl_PgaB; TIGR03938 1100841007213 N-terminal putative catalytic polysaccharide deacetylase domain of bacterial poly-beta-1,6-N-acetyl-D-glucosamine N-deacetylase PgaB, and similar proteins; Region: CE4_PgaB_5s; cd10964 1100841007214 putative active site [active] 1100841007215 putative metal binding site [ion binding]; other site 1100841007216 poly-beta-1,6 N-acetyl-D-glucosamine export porin PgaA; Region: PGA_TPR_OMP; TIGR03939 1100841007217 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1100841007218 binding surface 1100841007219 TPR motif; other site 1100841007220 PEP synthetase regulatory protein; Provisional; Region: PRK05339 1100841007221 phosphoenolpyruvate synthase; Validated; Region: PRK06464 1100841007222 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 1100841007223 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1100841007224 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 1100841007225 Domain of unknown function (DUF4339); Region: DUF4339; pfam14237 1100841007226 RDD family; Region: RDD; pfam06271 1100841007227 cytochrome o ubiquinol oxidase subunit II; Region: CyoA; TIGR01433 1100841007228 COX Aromatic Rich Motif; Region: COX_ARM; pfam06481 1100841007229 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 1100841007230 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 1100841007231 D-pathway; other site 1100841007232 Putative ubiquinol binding site [chemical binding]; other site 1100841007233 Low-spin heme (heme b) binding site [chemical binding]; other site 1100841007234 Putative water exit pathway; other site 1100841007235 Binuclear center (heme o3/CuB) [ion binding]; other site 1100841007236 K-pathway; other site 1100841007237 Putative proton exit pathway; other site 1100841007238 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 1100841007239 Subunit I/III interface [polypeptide binding]; other site 1100841007240 Subunit III/IV interface [polypeptide binding]; other site 1100841007241 cytochrome o ubiquinol oxidase subunit IV; Provisional; Region: PRK10582 1100841007242 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 1100841007243 UbiA prenyltransferase family; Region: UbiA; pfam01040 1100841007244 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 1100841007245 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 1100841007246 replicative DNA helicase; Region: DnaB; TIGR00665 1100841007247 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 1100841007248 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 1100841007249 Walker A motif; other site 1100841007250 ATP binding site [chemical binding]; other site 1100841007251 Walker B motif; other site 1100841007252 DNA binding loops [nucleotide binding] 1100841007253 alanine racemase; Reviewed; Region: alr; PRK00053 1100841007254 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827 1100841007255 active site 1100841007256 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1100841007257 substrate binding site [chemical binding]; other site 1100841007258 catalytic residues [active] 1100841007259 dimer interface [polypeptide binding]; other site 1100841007260 Predicted proteasome-type protease [Posttranslational modification, protein turnover, chaperones]; Region: COG3484 1100841007261 Bacterial proteasome, beta subunit. The 20S proteasome, multisubunit proteolytic complex, is the central enzyme of nonlysosomal protein degradation in both the cytosol and nucleus. It is composed of 28 subunits arranged as four homoheptameric rings that...; Region: proteasome_beta_bacterial; cd03765 1100841007262 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 1100841007263 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 1100841007264 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 1100841007265 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168 1100841007266 Uncharacterized conserved protein [Function unknown]; Region: COG2308 1100841007267 Predicted transcriptional regulator [Transcription]; Region: COG2378 1100841007268 WYL domain; Region: WYL; pfam13280 1100841007269 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 1100841007270 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 1100841007271 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 1100841007272 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 1100841007273 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1100841007274 S-adenosylmethionine binding site [chemical binding]; other site 1100841007275 MJ0042 family finger-like domain; Region: MJ0042_CXXC; TIGR02098 1100841007276 Protein of unknown function (DUF3426); Region: DUF3426; pfam11906 1100841007277 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 1100841007278 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 1100841007279 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 1100841007280 purine monophosphate binding site [chemical binding]; other site 1100841007281 dimer interface [polypeptide binding]; other site 1100841007282 putative catalytic residues [active] 1100841007283 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 1100841007284 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 1100841007285 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 1100841007286 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 1100841007287 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 1100841007288 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 1100841007289 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 1100841007290 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 1100841007291 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 1100841007292 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 1100841007293 Walker A/P-loop; other site 1100841007294 ATP binding site [chemical binding]; other site 1100841007295 Q-loop/lid; other site 1100841007296 ABC transporter signature motif; other site 1100841007297 Walker B; other site 1100841007298 D-loop; other site 1100841007299 H-loop/switch region; other site 1100841007300 NIL domain; Region: NIL; pfam09383 1100841007301 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1100841007302 dimer interface [polypeptide binding]; other site 1100841007303 conserved gate region; other site 1100841007304 ABC-ATPase subunit interface; other site 1100841007305 hydroxyacylglutathione hydrolase; Region: GSH_gloB; TIGR03413 1100841007306 C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663 1100841007307 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1100841007308 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1100841007309 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1100841007310 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1100841007311 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl17904 1100841007312 DDE domain; Region: DDE_Tnp_IS240; pfam13610 1100841007313 Integrase core domain; Region: rve; pfam00665 1100841007314 Initiator Replication protein; Region: Rep_3; pfam01051 1100841007315 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2739; cl17893 1100841007316 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 1100841007317 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 1100841007318 Modifier of rudimentary (Mod(r)) protein; Region: Mod_r; pfam07200 1100841007319 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 1100841007320 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 1100841007321 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 1100841007322 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 1100841007323 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 1100841007324 Macrolide 2'-Phosphotransferase (MPH2'). MPH2' is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase; Region: MPH2' cd05152 1100841007325 putative active site [active] 1100841007326 putative substrate binding site [chemical binding]; other site 1100841007327 Phosphotransferase enzyme family; Region: APH; pfam01636 1100841007328 ATP binding site [chemical binding]; other site 1100841007329 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1100841007330 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1100841007331 ABC transporter; Region: ABC_tran_2; pfam12848 1100841007332 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1100841007333 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1100841007334 Ribosomal RNA methyltransferase (FmrO); Region: FmrO; pfam07091 1100841007335 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1100841007336 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 1100841007337 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1100841007338 Transposase zinc-binding domain; Region: Zn_Tnp_IS91; pfam14319 1100841007339 Ribosomal protein S27; Region: Ribosomal_S27e; cl00897 1100841007340 Putative transposase; Region: Y2_Tnp; pfam04986 1100841007341 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 1100841007342 dihydropteroate synthase; Region: DHPS; TIGR01496 1100841007343 substrate binding pocket [chemical binding]; other site 1100841007344 dimer interface [polypeptide binding]; other site 1100841007345 inhibitor binding site; inhibition site 1100841007346 Small Multidrug Resistance protein; Region: Multi_Drug_Res; pfam00893 1100841007347 Domain of unknown function (DUF4111); Region: DUF4111; pfam13427 1100841007348 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 1100841007349 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 1100841007350 trimer interface [polypeptide binding]; other site 1100841007351 active site 1100841007352 substrate binding site [chemical binding]; other site 1100841007353 CoA binding site [chemical binding]; other site 1100841007354 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 1100841007355 Siderophore biosynthesis protein domain; Region: AlcB; smart01006 1100841007356 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1100841007357 Coenzyme A binding pocket [chemical binding]; other site 1100841007358 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1100841007359 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 1100841007360 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 1100841007361 Integrase core domain; Region: rve; pfam00665 1100841007362 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1100841007363 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1100841007364 Coenzyme A binding pocket [chemical binding]; other site 1100841007365 potential frameshift: common BLAST hit: gi|215482964|ref|YP_002325169.1| L-sorbosone dehydrogenase(SNDH) 1100841007366 Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133 1100841007367 Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133 1100841007368 aromatic amino acid exporter; Provisional; Region: PRK11689 1100841007369 EamA-like transporter family; Region: EamA; pfam00892 1100841007370 Aspartate racemase [Cell envelope biogenesis, outer membrane]; Region: RacX; COG1794 1100841007371 aspartate racemase; Region: asp_race; TIGR00035 1100841007372 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3009 1100841007373 Protein of unknown function (DUF330); Region: DUF330; pfam03886 1100841007374 mce related protein; Region: MCE; pfam02470 1100841007375 mce related protein; Region: MCE; pfam02470 1100841007376 mce related protein; Region: MCE; pfam02470 1100841007377 Paraquat-inducible protein A; Region: PqiA; pfam04403 1100841007378 Paraquat-inducible protein A; Region: PqiA; pfam04403 1100841007379 aspartate-alanine antiporter; Region: Asp_Ala_antiprt; TIGR03802 1100841007380 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 1100841007381 TrkA-C domain; Region: TrkA_C; pfam02080 1100841007382 TrkA-C domain; Region: TrkA_C; pfam02080 1100841007383 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 1100841007384 aspartate 4-decarboxylase; Region: asp_4_decarbox; TIGR03801 1100841007385 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1100841007386 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1100841007387 homodimer interface [polypeptide binding]; other site 1100841007388 catalytic residue [active] 1100841007389 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1100841007390 EamA-like transporter family; Region: EamA; pfam00892 1100841007391 EamA-like transporter family; Region: EamA; pfam00892 1100841007392 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1100841007393 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1100841007394 proline/glycine betaine transporter; Provisional; Region: PRK10642 1100841007395 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1100841007396 putative substrate translocation pore; other site 1100841007397 Osmosensory transporter coiled coil; Region: Osmo_CC; pfam08946 1100841007398 Spore Coat Protein U domain; Region: SCPU; cl02253 1100841007399 Spore Coat Protein U domain; Region: SCPU; pfam05229 1100841007400 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 1100841007401 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 1100841007402 PapC C-terminal domain; Region: PapC_C; pfam13953 1100841007403 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 1100841007404 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 1100841007405 Spore Coat Protein U domain; Region: SCPU; pfam05229 1100841007406 Spore Coat Protein U domain; Region: SCPU; cl02253 1100841007407 Spore Coat Protein U domain; Region: SCPU; pfam05229 1100841007408 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1100841007409 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1100841007410 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1100841007411 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1100841007412 DNA-binding site [nucleotide binding]; DNA binding site 1100841007413 FCD domain; Region: FCD; pfam07729 1100841007414 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG2607 1100841007415 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1100841007416 Walker A motif; other site 1100841007417 ATP binding site [chemical binding]; other site 1100841007418 Walker B motif; other site 1100841007419 Na+/glutamate symporter [Amino acid transport and metabolism]; Region: GltS; COG0786 1100841007420 Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167 1100841007421 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 1100841007422 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1100841007423 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1100841007424 Helix-turn-helix domain; Region: HTH_18; pfam12833 1100841007425 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1100841007426 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 1100841007427 Sensors of blue-light using FAD; Region: BLUF; pfam04940 1100841007428 Bacterial OB fold (BOF) protein; Region: BOF; cl01196 1100841007429 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1100841007430 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1100841007431 active site 1100841007432 GlcNAc-PI de-N-acetylase; Region: PIG-L; pfam02585 1100841007433 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1100841007434 active site 1100841007435 Uncharacterized protein conserved in bacteria (DUF2171); Region: DUF2171; pfam09939 1100841007436 gamma-aminobutyrate permease; Region: GABAperm; TIGR01773 1100841007437 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 1100841007438 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 1100841007439 tetrameric interface [polypeptide binding]; other site 1100841007440 NAD binding site [chemical binding]; other site 1100841007441 catalytic residues [active] 1100841007442 beta alanine--pyruvate transaminase; Provisional; Region: PRK09221 1100841007443 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1100841007444 inhibitor-cofactor binding pocket; inhibition site 1100841007445 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1100841007446 catalytic residue [active] 1100841007447 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1100841007448 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1100841007449 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1100841007450 dimerization interface [polypeptide binding]; other site 1100841007451 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1100841007452 substrate binding site [chemical binding]; other site 1100841007453 activation loop (A-loop); other site 1100841007454 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1100841007455 Domain of unknown function (DUF3336); Region: DUF3336; pfam11815 1100841007456 Triacylglycerol lipase 3, 4, and 5 and Sugar-Dependent 1 lipase; Region: Pat_TGL3-4-5_SDP1; cd07206 1100841007457 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 1100841007458 active site 1100841007459 nucleophile elbow; other site 1100841007460 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG2607 1100841007461 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1100841007462 Walker A motif; other site 1100841007463 ATP binding site [chemical binding]; other site 1100841007464 Walker B motif; other site 1100841007465 UGMP family protein; Validated; Region: PRK09604 1100841007466 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 1100841007467 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 1100841007468 Yqey-like protein; Region: YqeY; pfam09424 1100841007469 Putative Zn-dependent protease, contains TPR repeats [General function prediction only]; Region: COG4783 1100841007470 Peptidase family M48; Region: Peptidase_M48; cl12018 1100841007471 bifunctional glyoxylate/hydroxypyruvate reductase B; Provisional; Region: PRK15409 1100841007472 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 1100841007473 dimerization interface [polypeptide binding]; other site 1100841007474 ligand binding site [chemical binding]; other site 1100841007475 NADP binding site [chemical binding]; other site 1100841007476 catalytic site [active] 1100841007477 Peptidase family M48; Region: Peptidase_M48; cl12018 1100841007478 amidophosphoribosyltransferase; Provisional; Region: PRK09246 1100841007479 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 1100841007480 active site 1100841007481 tetramer interface [polypeptide binding]; other site 1100841007482 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1100841007483 active site 1100841007484 Colicin V production protein; Region: Colicin_V; pfam02674 1100841007485 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 1100841007486 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 1100841007487 quinone interaction residues [chemical binding]; other site 1100841007488 active site 1100841007489 catalytic residues [active] 1100841007490 FMN binding site [chemical binding]; other site 1100841007491 substrate binding site [chemical binding]; other site 1100841007492 Type II secretion system (T2SS), protein M; Region: T2SM; cl01222 1100841007493 Type II secretion system (T2SS), protein L; Region: T2SL; pfam05134 1100841007494 GspL periplasmic domain; Region: GspL_C; cl14909 1100841007495 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1100841007496 catalytic core [active] 1100841007497 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 1100841007498 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 1100841007499 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 1100841007500 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 1100841007501 putative FMN binding site [chemical binding]; other site 1100841007502 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1100841007503 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1100841007504 ATP binding site [chemical binding]; other site 1100841007505 Mg++ binding site [ion binding]; other site 1100841007506 motif III; other site 1100841007507 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1100841007508 nucleotide binding region [chemical binding]; other site 1100841007509 ATP-binding site [chemical binding]; other site 1100841007510 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1100841007511 DNA-binding site [nucleotide binding]; DNA binding site 1100841007512 RNA-binding motif; other site 1100841007513 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 1100841007514 CPxP motif; other site 1100841007515 RNA polymerase factor sigma-32; Reviewed; Region: PRK06596 1100841007516 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 1100841007517 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1100841007518 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1100841007519 DNA binding residues [nucleotide binding] 1100841007520 Uncharacterized small membrane protein [Function unknown]; Region: COG2363 1100841007521 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 1100841007522 thiS-thiF/thiG interaction site; other site 1100841007523 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 1100841007524 ThiS interaction site; other site 1100841007525 putative active site [active] 1100841007526 tetramer interface [polypeptide binding]; other site 1100841007527 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4339 1100841007528 hypothetical protein; Validated; Region: PRK02101 1100841007529 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2945 1100841007530 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1100841007531 Xaa-His dipeptidase; Region: aa-his-dipept; TIGR01893 1100841007532 M20 Peptidase D has specificity for beta-alanyl-L-histidine dipeptide; Region: M20_pepD; cd03890 1100841007533 metal binding site [ion binding]; metal-binding site 1100841007534 dimer interface [polypeptide binding]; other site 1100841007535 bifunctional cyclohexadienyl dehydrogenase/ 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK14806 1100841007536 prephenate dehydrogenase; Validated; Region: PRK08507 1100841007537 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 1100841007538 hinge; other site 1100841007539 active site 1100841007540 Chorismate mutase type II; Region: CM_2; cl00693 1100841007541 Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077 1100841007542 Prephenate dehydratase; Region: PDT; pfam00800 1100841007543 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 1100841007544 putative L-Phe binding site [chemical binding]; other site 1100841007545 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 1100841007546 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1100841007547 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1100841007548 active site 1100841007549 C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663 1100841007550 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1100841007551 hypothetical protein; Validated; Region: PRK09071 1100841007552 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 1100841007553 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 1100841007554 Protein of unknown function (DUF1315); Region: DUF1315; pfam07023 1100841007555 NAD kinase [Coenzyme metabolism]; Region: nadF; cl01255 1100841007556 penicillin-binding protein 1B; Region: PBP_1b; TIGR02071 1100841007557 Transglycosylase; Region: Transgly; pfam00912 1100841007558 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 1100841007559 hypothetical protein; Provisional; Region: PRK08999 1100841007560 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 1100841007561 active site 1100841007562 8-oxo-dGMP binding site [chemical binding]; other site 1100841007563 nudix motif; other site 1100841007564 metal binding site [ion binding]; metal-binding site 1100841007565 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 1100841007566 thiamine phosphate binding site [chemical binding]; other site 1100841007567 active site 1100841007568 Hemin uptake protein hemP; Region: hemP; cl10043 1100841007569 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1100841007570 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1100841007571 dimer interface [polypeptide binding]; other site 1100841007572 phosphorylation site [posttranslational modification] 1100841007573 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1100841007574 ATP binding site [chemical binding]; other site 1100841007575 Mg2+ binding site [ion binding]; other site 1100841007576 G-X-G motif; other site 1100841007577 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1100841007578 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1100841007579 active site 1100841007580 phosphorylation site [posttranslational modification] 1100841007581 intermolecular recognition site; other site 1100841007582 dimerization interface [polypeptide binding]; other site 1100841007583 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1100841007584 DNA binding site [nucleotide binding] 1100841007585 Bacterial OB fold (BOF) protein; Region: BOF; cl01196 1100841007586 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 1100841007587 Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804 1100841007588 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 1100841007589 Walker A motif; other site 1100841007590 ATP binding site [chemical binding]; other site 1100841007591 Walker B motif; other site 1100841007592 Predicted membrane protein [Function unknown]; Region: COG3174 1100841007593 Domain of unknown function (DUF4010); Region: DUF4010; pfam13194 1100841007594 Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281 1100841007595 homodimer interaction site [polypeptide binding]; other site 1100841007596 cofactor binding site; other site 1100841007597 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 1100841007598 Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195 1100841007599 FAD binding pocket [chemical binding]; other site 1100841007600 FAD binding motif [chemical binding]; other site 1100841007601 phosphate binding motif [ion binding]; other site 1100841007602 beta-alpha-beta structure motif; other site 1100841007603 NAD binding pocket [chemical binding]; other site 1100841007604 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 1100841007605 hydroxyproline-2-epimerase; Provisional; Region: PRK13971 1100841007606 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1100841007607 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1100841007608 DNA-binding site [nucleotide binding]; DNA binding site 1100841007609 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1100841007610 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1100841007611 homodimer interface [polypeptide binding]; other site 1100841007612 catalytic residue [active] 1100841007613 putative protease; Provisional; Region: PRK15452 1100841007614 Peptidase family U32; Region: Peptidase_U32; pfam01136 1100841007615 archaeoflavoprotein, MJ0208 family; Region: flavo_MJ0208; TIGR02700 1100841007616 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 1100841007617 ABC-type histidine transport system, ATPase component [Amino acid transport and metabolism]; Region: HisP; COG4598 1100841007618 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1100841007619 Walker A/P-loop; other site 1100841007620 ATP binding site [chemical binding]; other site 1100841007621 Q-loop/lid; other site 1100841007622 ABC transporter signature motif; other site 1100841007623 Walker B; other site 1100841007624 D-loop; other site 1100841007625 H-loop/switch region; other site 1100841007626 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1100841007627 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1100841007628 dimer interface [polypeptide binding]; other site 1100841007629 conserved gate region; other site 1100841007630 putative PBP binding loops; other site 1100841007631 ABC-ATPase subunit interface; other site 1100841007632 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1100841007633 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1100841007634 dimer interface [polypeptide binding]; other site 1100841007635 conserved gate region; other site 1100841007636 putative PBP binding loops; other site 1100841007637 ABC-ATPase subunit interface; other site 1100841007638 lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096 1100841007639 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1100841007640 substrate binding pocket [chemical binding]; other site 1100841007641 membrane-bound complex binding site; other site 1100841007642 hinge residues; other site 1100841007643 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1100841007644 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1100841007645 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 1100841007646 putative effector binding pocket; other site 1100841007647 putative dimerization interface [polypeptide binding]; other site 1100841007648 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1100841007649 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1100841007650 HlyD family secretion protein; Region: HlyD_3; pfam13437 1100841007651 AcrB/AcrD/AcrF family; Region: ACR_tran; pfam00873 1100841007652 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 1100841007653 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 1100841007654 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 1100841007655 dimer interface [polypeptide binding]; other site 1100841007656 active site 1100841007657 glycine-pyridoxal phosphate binding site [chemical binding]; other site 1100841007658 folate binding site [chemical binding]; other site 1100841007659 Family of unknown function (DUF695); Region: DUF695; pfam05117 1100841007660 Protein of unknown function (DUF1260); Region: DUF1260; pfam06877 1100841007661 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1100841007662 Secretory lipase; Region: LIP; pfam03583 1100841007663 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 1100841007664 exodeoxyribonuclease X; Provisional; Region: PRK07983 1100841007665 active site 1100841007666 catalytic site [active] 1100841007667 substrate binding site [chemical binding]; other site 1100841007668 Protein of unknown function (DUF3820); Region: DUF3820; cl01411 1100841007669 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1100841007670 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1100841007671 Walker A/P-loop; other site 1100841007672 ATP binding site [chemical binding]; other site 1100841007673 Q-loop/lid; other site 1100841007674 ABC transporter signature motif; other site 1100841007675 Walker B; other site 1100841007676 D-loop; other site 1100841007677 H-loop/switch region; other site 1100841007678 inner membrane transport permease; Provisional; Region: PRK15066 1100841007679 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1100841007680 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2904 1100841007681 7-cyano-7-deazaguanine reductase; Provisional; Region: queF; PRK11792 1100841007682 Enzyme related to GTP cyclohydrolase I [General function prediction only]; Region: COG0780 1100841007683 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 1100841007684 Transglycosylase SLT domain; Region: SLT_2; pfam13406 1100841007685 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1100841007686 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1100841007687 catalytic residue [active] 1100841007688 Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797 1100841007689 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 1100841007690 Protein of unknown function (DUF962); Region: DUF962; cl01879 1100841007691 Branched-chain amino acid transport protein (AzlD); Region: AzlD; pfam05437 1100841007692 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 1100841007693 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1100841007694 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1100841007695 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1100841007696 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1100841007697 Protein of unknown function (DUF3465); Region: DUF3465; pfam11948 1100841007698 elongation factor Ts; Provisional; Region: tsf; PRK09377 1100841007699 UBA/TS-N domain; Region: UBA; pfam00627 1100841007700 Elongation factor TS; Region: EF_TS; pfam00889 1100841007701 Elongation factor TS; Region: EF_TS; pfam00889 1100841007702 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 1100841007703 rRNA interaction site [nucleotide binding]; other site 1100841007704 S8 interaction site; other site 1100841007705 putative laminin-1 binding site; other site 1100841007706 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 1100841007707 active site 1100841007708 Outer membrane protein W [Cell envelope biogenesis, outer membrane]; Region: OmpW; COG3047 1100841007709 nitrite extrusion protein (nitrite facilitator); Region: 2A0108; TIGR00886 1100841007710 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1100841007711 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1100841007712 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1100841007713 putative substrate translocation pore; other site 1100841007714 leucine-responsive transcriptional regulator; Provisional; Region: PRK11169 1100841007715 soluble pyridine nucleotide transhydrogenase; Provisional; Region: PRK05249 1100841007716 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1100841007717 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1100841007718 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1100841007719 lipoyl synthase; Provisional; Region: PRK05481 1100841007720 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1100841007721 FeS/SAM binding site; other site 1100841007722 acyl-CoA dehydrogenase; Reviewed; Region: fadE; PRK09463 1100841007723 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1100841007724 active site 1100841007725 Domain of unknown function (DUF1974); Region: DUF1974; pfam09317 1100841007726 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 1100841007727 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 1100841007728 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 1100841007729 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 1100841007730 homotetramer interface [polypeptide binding]; other site 1100841007731 ligand binding site [chemical binding]; other site 1100841007732 catalytic site [active] 1100841007733 NAD binding site [chemical binding]; other site 1100841007734 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 1100841007735 FAD binding site [chemical binding]; other site 1100841007736 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 1100841007737 RNA methyltransferase, RsmE family; Region: TIGR00046 1100841007738 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1100841007739 PAS fold; Region: PAS_3; pfam08447 1100841007740 heme pocket [chemical binding]; other site 1100841007741 putative active site [active] 1100841007742 PAS domain S-box; Region: sensory_box; TIGR00229 1100841007743 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1100841007744 putative active site [active] 1100841007745 heme pocket [chemical binding]; other site 1100841007746 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1100841007747 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1100841007748 metal binding site [ion binding]; metal-binding site 1100841007749 active site 1100841007750 I-site; other site 1100841007751 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1100841007752 bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed; Region: PRK07232 1100841007753 Malic enzyme, N-terminal domain; Region: malic; pfam00390 1100841007754 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 1100841007755 putative NAD(P) binding site [chemical binding]; other site 1100841007756 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 1100841007757 multifunctional tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase; Reviewed; Region: cca; PRK10885 1100841007758 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 1100841007759 active site 1100841007760 NTP binding site [chemical binding]; other site 1100841007761 metal binding triad [ion binding]; metal-binding site 1100841007762 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 1100841007763 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1100841007764 Zn2+ binding site [ion binding]; other site 1100841007765 Mg2+ binding site [ion binding]; other site 1100841007766 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1100841007767 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1100841007768 protein binding site [polypeptide binding]; other site 1100841007769 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371 1100841007770 Uncharacterized conserved protein [Function unknown]; Region: COG0327 1100841007771 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 1100841007772 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 1100841007773 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 1100841007774 Protein of unknown function (DUF2726); Region: DUF2726; pfam10881 1100841007775 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 1100841007776 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1100841007777 4-hydroxybenzoate octaprenyltransferase; Reviewed; Region: ubiA; PRK12848 1100841007778 UbiA prenyltransferase family; Region: UbiA; pfam01040 1100841007779 Chorismate lyase; Region: Chor_lyase; cl01230 1100841007780 glutamine synthetase; Provisional; Region: glnA; PRK09469 1100841007781 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 1100841007782 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1100841007783 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 1100841007784 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1100841007785 putative substrate translocation pore; other site 1100841007786 POT family; Region: PTR2; cl17359 1100841007787 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 1100841007788 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 1100841007789 X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP; cd01085 1100841007790 active site 1100841007791 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 1100841007792 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 1100841007793 glutamine binding [chemical binding]; other site 1100841007794 catalytic triad [active] 1100841007795 Peptidase family M1; Region: Peptidase_M1; pfam01433 1100841007796 Peptidase M1 Aminopeptidase N family incudes tricorn interacting factor F3, Endoplasmic reticulum aminopeptidase 1 (ERAP1), Aminopeptidase Q (APQ); Region: M1_APN_2; cd09601 1100841007797 Zn binding site [ion binding]; other site 1100841007798 Domain of unknown function (DUF3358); Region: DUF3358; pfam11838 1100841007799 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 1100841007800 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 1100841007801 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 1100841007802 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 1100841007803 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 1100841007804 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 1100841007805 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 1100841007806 active site 1100841007807 ribulose/triose binding site [chemical binding]; other site 1100841007808 phosphate binding site [ion binding]; other site 1100841007809 substrate (anthranilate) binding pocket [chemical binding]; other site 1100841007810 product (indole) binding pocket [chemical binding]; other site 1100841007811 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2840 1100841007812 Smr domain; Region: Smr; pfam01713 1100841007813 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 1100841007814 xanthine dehydrogenase accessory protein XdhC; Region: xanthine_xdhC; TIGR02964 1100841007815 XdhC Rossmann domain; Region: XdhC_C; pfam13478 1100841007816 xanthine dehydrogenase, molybdopterin binding subunit; Region: xanthine_xdhB; TIGR02965 1100841007817 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 1100841007818 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 1100841007819 xanthine dehydrogenase, small subunit; Region: xanthine_xdhA; TIGR02963 1100841007820 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 1100841007821 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 1100841007822 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450 1100841007823 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 1100841007824 homodecamer interface [polypeptide binding]; other site 1100841007825 GTP cyclohydrolase I; Provisional; Region: PLN03044 1100841007826 active site 1100841007827 putative catalytic site residues [active] 1100841007828 zinc binding site [ion binding]; other site 1100841007829 GTP-CH-I/GFRP interaction surface; other site 1100841007830 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1100841007831 beta-lactamase/D-alanine carboxypeptidase; Provisional; Region: ampC; PRK11289 1100841007832 Domain of unknown function (DUF4105); Region: DUF4105; pfam13387 1100841007833 Protein of unknown function (DUF3015); Region: DUF3015; pfam11220 1100841007834 Protein of unknown function (DUF817); Region: DUF817; pfam05675 1100841007835 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 1100841007836 substrate binding site [chemical binding]; other site 1100841007837 active site 1100841007838 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1100841007839 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 1100841007840 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 1100841007841 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1100841007842 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 1100841007843 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 1100841007844 Thioesterase domain; Region: Thioesterase; pfam00975 1100841007845 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1100841007846 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 1100841007847 Walker A/P-loop; other site 1100841007848 ATP binding site [chemical binding]; other site 1100841007849 Q-loop/lid; other site 1100841007850 ABC transporter signature motif; other site 1100841007851 Walker B; other site 1100841007852 D-loop; other site 1100841007853 H-loop/switch region; other site 1100841007854 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1100841007855 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1100841007856 Walker A/P-loop; other site 1100841007857 ATP binding site [chemical binding]; other site 1100841007858 Q-loop/lid; other site 1100841007859 ABC transporter signature motif; other site 1100841007860 Walker B; other site 1100841007861 D-loop; other site 1100841007862 H-loop/switch region; other site 1100841007863 histidine decarboxylase; Provisional; Region: PRK02769 1100841007864 Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155 1100841007865 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1100841007866 catalytic residue [active] 1100841007867 Isochorismatase, also known as 2,3 dihydro-2,3 dihydroxybenzoate synthase, catalyses the conversion of isochorismate, in the presence of water, to 2,3-dihydroxybenzoate and pyruvate, via the hydrolysis of a vinyl ether, an uncommon reaction in biological...; Region: isochorismatase; cd01013 1100841007868 hydrophobic substrate binding pocket; other site 1100841007869 Isochorismatase family; Region: Isochorismatase; pfam00857 1100841007870 active site 1100841007871 conserved cis-peptide bond; other site 1100841007872 Aryl carrier domain [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3433 1100841007873 enterobactin synthase subunit E; Provisional; Region: entE; PRK10946 1100841007874 2,3-dihydroxybenzoate-AMP ligase; Region: 23DHB-AMP_lg; cd05920 1100841007875 acyl-activating enzyme (AAE) consensus motif; other site 1100841007876 active site 1100841007877 AMP binding site [chemical binding]; other site 1100841007878 substrate binding site [chemical binding]; other site 1100841007879 Condensation domain; Region: Condensation; pfam00668 1100841007880 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1100841007881 Nonribosomal peptide synthase; Region: NRPS; pfam08415 1100841007882 Condensation domain; Region: Condensation; pfam00668 1100841007883 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1100841007884 Nonribosomal peptide synthase; Region: NRPS; pfam08415 1100841007885 Lysine/ornithine N-monooxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: IucD; COG3486 1100841007886 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1100841007887 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 1100841007888 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1100841007889 N-terminal plug; other site 1100841007890 ligand-binding site [chemical binding]; other site 1100841007891 ABC-type enterochelin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: CeuA; COG4607 1100841007892 Siderophore binding protein FatB. These proteins have been shown to function as ABC-type initial receptors in the siderophore-mediated iron uptake in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins...; Region: FatB; cd01140 1100841007893 putative ligand binding residues [chemical binding]; other site 1100841007894 ABC-type enterochelin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CeuD; COG4604 1100841007895 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1100841007896 Walker A/P-loop; other site 1100841007897 ATP binding site [chemical binding]; other site 1100841007898 Q-loop/lid; other site 1100841007899 ABC transporter signature motif; other site 1100841007900 Walker B; other site 1100841007901 D-loop; other site 1100841007902 H-loop/switch region; other site 1100841007903 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1100841007904 ABC-ATPase subunit interface; other site 1100841007905 dimer interface [polypeptide binding]; other site 1100841007906 putative PBP binding regions; other site 1100841007907 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1100841007908 ABC-ATPase subunit interface; other site 1100841007909 dimer interface [polypeptide binding]; other site 1100841007910 putative PBP binding regions; other site 1100841007911 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1100841007912 Condensation domain; Region: Condensation; pfam00668 1100841007913 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1100841007914 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; Region: A_NRPS_TlmIV_like; cd12114 1100841007915 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 1100841007916 acyl-activating enzyme (AAE) consensus motif; other site 1100841007917 AMP binding site [chemical binding]; other site 1100841007918 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 1100841007919 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 1100841007920 FAD binding pocket [chemical binding]; other site 1100841007921 FAD binding motif [chemical binding]; other site 1100841007922 phosphate binding motif [ion binding]; other site 1100841007923 NAD binding pocket [chemical binding]; other site 1100841007924 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964 1100841007925 YheO-like PAS domain; Region: PAS_6; pfam08348 1100841007926 HTH domain; Region: HTH_22; pfam13309 1100841007927 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 1100841007928 catalytic residue [active] 1100841007929 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 1100841007930 Pirin-related protein [General function prediction only]; Region: COG1741 1100841007931 Pirin; Region: Pirin; pfam02678 1100841007932 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1100841007933 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1100841007934 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1100841007935 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1100841007936 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1100841007937 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1100841007938 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR9; cd08274 1100841007939 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1100841007940 putative NAD(P) binding site [chemical binding]; other site 1100841007941 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 1100841007942 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 1100841007943 metal binding site [ion binding]; metal-binding site 1100841007944 substrate binding pocket [chemical binding]; other site 1100841007945 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 1100841007946 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1100841007947 putative substrate translocation pore; other site 1100841007948 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1100841007949 Antitoxin of toxin-antitoxin stability system N-terminal; Region: RelB_N; pfam12910 1100841007950 EamA-like transporter family; Region: EamA; pfam00892 1100841007951 EamA-like transporter family; Region: EamA; pfam00892 1100841007952 aromatic amino acid exporter; Provisional; Region: PRK11689 1100841007953 Multiple antibiotic transporter [Intracellular trafficking and secretion]; Region: MarC; COG2095 1100841007954 ethanolamine utilization protein EutQ; Provisional; Region: PRK15457 1100841007955 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 1100841007956 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1100841007957 Rubredoxin [Energy production and conversion]; Region: COG1773 1100841007958 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 1100841007959 iron binding site [ion binding]; other site 1100841007960 NADH:flavorubredoxin oxidoreductase; Provisional; Region: PRK04965 1100841007961 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1100841007962 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1100841007963 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1100841007964 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1100841007965 NAD(P) binding site [chemical binding]; other site 1100841007966 catalytic residues [active] 1100841007967 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 1100841007968 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 1100841007969 [2Fe-2S] cluster binding site [ion binding]; other site 1100841007970 C-terminal catalytic domain of the oxygenase alpha subunit of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C; cd00680 1100841007971 alpha subunit interface [polypeptide binding]; other site 1100841007972 active site 1100841007973 substrate binding site [chemical binding]; other site 1100841007974 Fe binding site [ion binding]; other site 1100841007975 BCCT family transporter; Region: BCCT; pfam02028 1100841007976 BCCT family transporter; Region: BCCT; pfam02028 1100841007977 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 1100841007978 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1100841007979 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 1100841007980 dimerization interface [polypeptide binding]; other site 1100841007981 substrate binding pocket [chemical binding]; other site 1100841007982 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 1100841007983 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 1100841007984 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 1100841007985 tetrameric interface [polypeptide binding]; other site 1100841007986 NAD binding site [chemical binding]; other site 1100841007987 catalytic residues [active] 1100841007988 Protein of unknown function (DUF861); Region: Cupin_3; pfam05899 1100841007989 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 1100841007990 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1100841007991 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 1100841007992 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1100841007993 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1100841007994 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1100841007995 Phage antirepressor protein KilAC domain; Region: ANT; cl01462 1100841007996 Protein of unknown function (DUF466); Region: DUF466; pfam04328 1100841007997 carbon starvation protein A; Provisional; Region: PRK15015 1100841007998 Carbon starvation protein CstA; Region: CstA; pfam02554 1100841007999 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 1100841008000 elongation factor P; Validated; Region: PRK00529 1100841008001 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 1100841008002 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 1100841008003 RNA binding site [nucleotide binding]; other site 1100841008004 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 1100841008005 RNA binding site [nucleotide binding]; other site 1100841008006 Radical SAM superfamily; Region: Radical_SAM; pfam04055 1100841008007 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1100841008008 FeS/SAM binding site; other site 1100841008009 Phage-related minor tail protein [Function unknown]; Region: COG5281 1100841008010 tape measure domain; Region: tape_meas_nterm; TIGR02675 1100841008011 Phage major tail protein 2; Region: Phage_tail_2; cl11463 1100841008012 Bacteriophage protein of unknown function (DUF646); Region: DUF646; cl12124 1100841008013 Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054 1100841008014 oligomerization interface [polypeptide binding]; other site 1100841008015 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 1100841008016 Phage capsid family; Region: Phage_capsid; pfam05065 1100841008017 Caudovirus prohead protease; Region: Peptidase_U35; pfam04586 1100841008018 Phage portal protein; Region: Phage_portal; pfam04860 1100841008019 Phage-related protein [Function unknown]; Region: COG4695 1100841008020 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 1100841008021 Phage terminase, small subunit; Region: Terminase_4; pfam05119 1100841008022 Phage associated DNA primase [General function prediction only]; Region: COG3378 1100841008023 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4643 1100841008024 Zinc-binding domain of primase-helicase; Region: Prim_Zn_Ribbon; smart00778 1100841008025 TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029 1100841008026 active site 1100841008027 metal binding site [ion binding]; metal-binding site 1100841008028 interdomain interaction site; other site 1100841008029 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1100841008030 non-specific DNA binding site [nucleotide binding]; other site 1100841008031 salt bridge; other site 1100841008032 sequence-specific DNA binding site [nucleotide binding]; other site 1100841008033 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1100841008034 Catalytic site [active] 1100841008035 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 1100841008036 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1100841008037 active site 1100841008038 DNA binding site [nucleotide binding] 1100841008039 Int/Topo IB signature motif; other site 1100841008040 Protein of unknown function (DUF466); Region: DUF466; pfam04328 1100841008041 carbon starvation protein A; Provisional; Region: PRK15015 1100841008042 Carbon starvation protein CstA; Region: CstA; pfam02554 1100841008043 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 1100841008044 elongation factor P; Validated; Region: PRK00529 1100841008045 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 1100841008046 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 1100841008047 RNA binding site [nucleotide binding]; other site 1100841008048 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 1100841008049 RNA binding site [nucleotide binding]; other site 1100841008050 Radical SAM superfamily; Region: Radical_SAM; pfam04055 1100841008051 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1100841008052 FeS/SAM binding site; other site 1100841008053 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cl00290 1100841008054 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 1100841008055 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 1100841008056 SBF-like CPA transporter family (DUF4137); Region: DUF4137; pfam13593 1100841008057 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1100841008058 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 1100841008059 dimer interface [polypeptide binding]; other site 1100841008060 active site 1100841008061 metal binding site [ion binding]; metal-binding site 1100841008062 glutathione binding site [chemical binding]; other site 1100841008063 muropeptide transporter; Validated; Region: ampG; cl17669 1100841008064 muropeptide transporter; Validated; Region: ampG; cl17669 1100841008065 muropeptide transporter; Validated; Region: ampG; cl17669 1100841008066 AAA domain; Region: AAA_32; pfam13654 1100841008067 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cl00148 1100841008068 primary dimer interface [polypeptide binding]; other site 1100841008069 lon-related putative ATP-dependent protease; Region: lon_rel; TIGR00764 1100841008070 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 1100841008071 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1100841008072 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1100841008073 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1100841008074 putative effector binding pocket; other site 1100841008075 dimerization interface [polypeptide binding]; other site 1100841008076 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1100841008077 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1100841008078 Peptidase family M23; Region: Peptidase_M23; pfam01551 1100841008079 Survival protein SurE; Region: SurE; cl00448 1100841008080 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1100841008081 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 1100841008082 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 1100841008083 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 1100841008084 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 1100841008085 trimer interface [polypeptide binding]; other site 1100841008086 putative metal binding site [ion binding]; other site 1100841008087 Contains a crystal structure of the Nudix hydrolase from Nitrosomonas europaea, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_2; cd03675 1100841008088 nudix motif; other site 1100841008089 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 1100841008090 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 1100841008091 putative lysogenization regulator; Reviewed; Region: PRK00218 1100841008092 adenylosuccinate lyase; Provisional; Region: PRK09285 1100841008093 PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598 1100841008094 tetramer interface [polypeptide binding]; other site 1100841008095 active site 1100841008096 Predicted membrane protein (DUF2238); Region: DUF2238; pfam09997 1100841008097 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1100841008098 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 1100841008099 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 1100841008100 tandem repeat interface [polypeptide binding]; other site 1100841008101 oligomer interface [polypeptide binding]; other site 1100841008102 active site residues [active] 1100841008103 phosphate transporter ATP-binding protein; Provisional; Region: PRK14235 1100841008104 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 1100841008105 Walker A/P-loop; other site 1100841008106 ATP binding site [chemical binding]; other site 1100841008107 Q-loop/lid; other site 1100841008108 ABC transporter signature motif; other site 1100841008109 Walker B; other site 1100841008110 D-loop; other site 1100841008111 H-loop/switch region; other site 1100841008112 Domain of unknown function (DUF3333); Region: DUF3333; pfam11812 1100841008113 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 1100841008114 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1100841008115 dimer interface [polypeptide binding]; other site 1100841008116 conserved gate region; other site 1100841008117 putative PBP binding loops; other site 1100841008118 ABC-ATPase subunit interface; other site 1100841008119 Phosphate ATP-binding cassette transporter; Region: DUF3708; pfam12501 1100841008120 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 1100841008121 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1100841008122 dimer interface [polypeptide binding]; other site 1100841008123 conserved gate region; other site 1100841008124 putative PBP binding loops; other site 1100841008125 ABC-ATPase subunit interface; other site 1100841008126 ABC-type phosphate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PstS; COG0226 1100841008127 aromatic amino acid transporter; Provisional; Region: PRK10238 1100841008128 Pyruvate decarboxylase and related thiamine pyrophosphate-requiring enzymes [Carbohydrate transport and metabolism / Coenzyme metabolism / General function prediction only]; Region: COG3961 1100841008129 Pyrimidine (PYR) binding domain of pyruvate decarboxylase (PDC), indolepyruvate decarboxylase (IPDC) and related proteins; Region: TPP_PYR_PDC_IPDC_like; cd07038 1100841008130 dimer interface [polypeptide binding]; other site 1100841008131 PYR/PP interface [polypeptide binding]; other site 1100841008132 TPP binding site [chemical binding]; other site 1100841008133 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1100841008134 Thiamine pyrophosphate (TPP) family, PDC_IPDC subfamily, TPP-binding module; composed of proteins similar to pyruvate decarboxylase (PDC) and indolepyruvate decarboxylase (IPDC). PDC, a key enzyme in alcoholic fermentation, catalyzes the conversion of...; Region: TPP_PDC_IPDC; cd02005 1100841008135 TPP-binding site [chemical binding]; other site 1100841008136 dimer interface [polypeptide binding]; other site 1100841008137 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1100841008138 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 1100841008139 AsnC family; Region: AsnC_trans_reg; pfam01037 1100841008140 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1100841008141 Streptomyces aureofaciens putative aldehyde dehydrogenase AldA (AAD23400)-like; Region: ALDH_AldA-AAD23400; cd07106 1100841008142 NAD(P) binding site [chemical binding]; other site 1100841008143 catalytic residues [active] 1100841008144 DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450 1100841008145 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1100841008146 catalytic residue [active] 1100841008147 diaminobutyrate--2-oxoglutarate aminotransferase; Provisional; Region: PRK06931 1100841008148 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1100841008149 inhibitor-cofactor binding pocket; inhibition site 1100841008150 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1100841008151 catalytic residue [active] 1100841008152 Protein of unknown function (DUF541); Region: SIMPL; cl01077 1100841008153 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1100841008154 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1100841008155 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1100841008156 CoenzymeA binding site [chemical binding]; other site 1100841008157 subunit interaction site [polypeptide binding]; other site 1100841008158 PHB binding site; other site 1100841008159 Fatty acid desaturase; Region: FA_desaturase; pfam00487 1100841008160 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 1100841008161 putative di-iron ligands [ion binding]; other site 1100841008162 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_2; cd06216 1100841008163 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 1100841008164 FAD binding pocket [chemical binding]; other site 1100841008165 FAD binding motif [chemical binding]; other site 1100841008166 phosphate binding motif [ion binding]; other site 1100841008167 beta-alpha-beta structure motif; other site 1100841008168 NAD binding pocket [chemical binding]; other site 1100841008169 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1100841008170 catalytic loop [active] 1100841008171 iron binding site [ion binding]; other site 1100841008172 DNA-binding transcriptional repressor FabR; Provisional; Region: PRK11202 1100841008173 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1100841008174 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465 1100841008175 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1100841008176 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1100841008177 ATP binding site [chemical binding]; other site 1100841008178 putative Mg++ binding site [ion binding]; other site 1100841008179 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1100841008180 nucleotide binding region [chemical binding]; other site 1100841008181 ATP-binding site [chemical binding]; other site 1100841008182 RNA polymerase recycling family C-terminal; Region: RapA_C; pfam12137 1100841008183 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1100841008184 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1100841008185 active site 1100841008186 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1100841008187 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 1100841008188 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1100841008189 inhibitor-cofactor binding pocket; inhibition site 1100841008190 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1100841008191 catalytic residue [active] 1100841008192 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 1100841008193 thiamine phosphate binding site [chemical binding]; other site 1100841008194 active site 1100841008195 pyrophosphate binding site [ion binding]; other site 1100841008196 Protein of unknown function (DUF962); Region: DUF962; pfam06127 1100841008197 Uncharacterized conserved protein [Function unknown]; Region: COG3025 1100841008198 Uncharacterized subgroup of the CYTH-like superfamily having an associated CHAD domain; Region: CYTH-like_Pase_CHAD; cd07756 1100841008199 putative active site [active] 1100841008200 putative metal binding residues [ion binding]; other site 1100841008201 signature motif; other site 1100841008202 putative triphosphate binding site [ion binding]; other site 1100841008203 The CHAD domain is an alpha-helical domain functionally associated with some members of the adenylate cyclase family; Region: CHAD; smart00880 1100841008204 Protein of unknown function (DUF3144); Region: DUF3144; pfam11342 1100841008205 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1100841008206 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 1100841008207 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1100841008208 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1100841008209 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1100841008210 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 1100841008211 Predicted Na+/dicarboxylate symporter [General function prediction only]; Region: COG1823 1100841008212 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1100841008213 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1100841008214 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1100841008215 The C-terminal substrate binding domain of LysR-type transcriptional regulators, YofA and SoxR, contains the type 2 periplasmic binding fold; Region: PBP2_YofA_SoxR_like; cd08442 1100841008216 putative dimerization interface [polypeptide binding]; other site 1100841008217 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1100841008218 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1100841008219 putative substrate translocation pore; other site 1100841008220 isocitrate dehydrogenase; Validated; Region: PRK06451 1100841008221 isocitrate dehydrogenase; Reviewed; Region: PRK07006 1100841008222 Pseudouridine synthase, Escherichia coli RluE; Region: PseudoU_synth_RluE; cd02566 1100841008223 pseudouridine synthase; Region: TIGR00093 1100841008224 probable active site [active] 1100841008225 Monomeric isocitrate dehydrogenase [Energy production and conversion]; Region: Icd; COG2838 1100841008226 Monomeric isocitrate dehydrogenase; Region: IDH; cl15383 1100841008227 Predicted protease with the C-terminal PDZ domain [General function prediction only]; Region: COG3975 1100841008228 M61 glycyl aminopeptidase; Region: Peptidase_M61; pfam05299 1100841008229 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1100841008230 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 1100841008231 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1100841008232 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 1100841008233 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1100841008234 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095 1100841008235 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1100841008236 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 1100841008237 DNA photolyase; Region: DNA_photolyase; pfam00875 1100841008238 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1100841008239 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 1100841008240 DXD motif; other site 1100841008241 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1100841008242 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 1100841008243 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 1100841008244 active site 1100841008245 homodimer interface [polypeptide binding]; other site 1100841008246 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1100841008247 TPR motif; other site 1100841008248 binding surface 1100841008249 Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_1; cd02432 1100841008250 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 1100841008251 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 1100841008252 FMN binding site [chemical binding]; other site 1100841008253 substrate binding site [chemical binding]; other site 1100841008254 putative catalytic residue [active] 1100841008255 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 1100841008256 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 1100841008257 FMN binding site [chemical binding]; other site 1100841008258 active site 1100841008259 catalytic residues [active] 1100841008260 substrate binding site [chemical binding]; other site 1100841008261 Protein of unknown function (DUF1615); Region: DUF1615; pfam07759 1100841008262 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 1100841008263 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1100841008264 gamma-glutamyl kinase; Provisional; Region: PRK05429 1100841008265 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 1100841008266 nucleotide binding site [chemical binding]; other site 1100841008267 homotetrameric interface [polypeptide binding]; other site 1100841008268 putative phosphate binding site [ion binding]; other site 1100841008269 putative allosteric binding site; other site 1100841008270 PUA domain; Region: PUA; pfam01472 1100841008271 GTPase CgtA; Reviewed; Region: obgE; PRK12298 1100841008272 GTP1/OBG; Region: GTP1_OBG; pfam01018 1100841008273 Obg GTPase; Region: Obg; cd01898 1100841008274 G1 box; other site 1100841008275 GTP/Mg2+ binding site [chemical binding]; other site 1100841008276 Switch I region; other site 1100841008277 G2 box; other site 1100841008278 G3 box; other site 1100841008279 Switch II region; other site 1100841008280 G4 box; other site 1100841008281 G5 box; other site 1100841008282 glyceraldehyde-3-phosphate dehydrogenase; Reviewed; Region: PRK08289 1100841008283 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 1100841008284 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 1100841008285 Predicted permeases [General function prediction only]; Region: RarD; COG2962 1100841008286 Bacterial lipocalin [Cell envelope biogenesis, outer membrane]; Region: Blc; COG3040 1100841008287 Lipocalin-like domain; Region: Lipocalin_2; pfam08212 1100841008288 excinuclease ABC subunit B; Provisional; Region: PRK05298 1100841008289 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1100841008290 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1100841008291 nucleotide binding region [chemical binding]; other site 1100841008292 ATP-binding site [chemical binding]; other site 1100841008293 Ultra-violet resistance protein B; Region: UvrB; pfam12344 1100841008294 UvrB/uvrC motif; Region: UVR; pfam02151 1100841008295 hypothetical protein; Region: PHA00684 1100841008296 PAS domain; Region: PAS_9; pfam13426 1100841008297 PAS domain; Region: PAS_9; pfam13426 1100841008298 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1100841008299 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1100841008300 metal binding site [ion binding]; metal-binding site 1100841008301 active site 1100841008302 I-site; other site 1100841008303 aspartate aminotransferase; Provisional; Region: PRK05764 1100841008304 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1100841008305 homodimer interface [polypeptide binding]; other site 1100841008306 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1100841008307 catalytic residue [active] 1100841008308 Uncharacterized conserved protein [Function unknown]; Region: COG3791 1100841008309 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1100841008310 CoenzymeA binding site [chemical binding]; other site 1100841008311 subunit interaction site [polypeptide binding]; other site 1100841008312 PHB binding site; other site 1100841008313 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1100841008314 malonic semialdehyde reductase; Provisional; Region: PRK10538 1100841008315 NAD(P) binding site [chemical binding]; other site 1100841008316 active site 1100841008317 MiaE tRNA-modifying nonheme diiron monooxygenase, ferritin-like diiron-binding domain; Region: MiaE; cd07910 1100841008318 active site 1100841008319 dinuclear metal binding site [ion binding]; other site 1100841008320 dimerization interface [polypeptide binding]; other site 1100841008321 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003 1100841008322 active site 1100841008323 hydrophilic channel; other site 1100841008324 dimerization interface [polypeptide binding]; other site 1100841008325 catalytic residues [active] 1100841008326 active site lid [active] 1100841008327 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 1100841008328 Recombination protein O N terminal; Region: RecO_N; pfam11967 1100841008329 Recombination protein O C terminal; Region: RecO_C; pfam02565 1100841008330 GTPase Era; Reviewed; Region: era; PRK00089 1100841008331 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 1100841008332 G1 box; other site 1100841008333 GTP/Mg2+ binding site [chemical binding]; other site 1100841008334 Switch I region; other site 1100841008335 G2 box; other site 1100841008336 Switch II region; other site 1100841008337 G3 box; other site 1100841008338 G4 box; other site 1100841008339 G5 box; other site 1100841008340 KH domain; Region: KH_2; pfam07650 1100841008341 ribonuclease III; Reviewed; Region: rnc; PRK00102 1100841008342 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 1100841008343 dimerization interface [polypeptide binding]; other site 1100841008344 active site 1100841008345 metal binding site [ion binding]; metal-binding site 1100841008346 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 1100841008347 dsRNA binding site [nucleotide binding]; other site 1100841008348 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 1100841008349 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1100841008350 Catalytic site [active] 1100841008351 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1100841008352 GTP-binding protein LepA; Provisional; Region: PRK05433 1100841008353 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 1100841008354 G1 box; other site 1100841008355 putative GEF interaction site [polypeptide binding]; other site 1100841008356 GTP/Mg2+ binding site [chemical binding]; other site 1100841008357 Switch I region; other site 1100841008358 G2 box; other site 1100841008359 G3 box; other site 1100841008360 Switch II region; other site 1100841008361 G4 box; other site 1100841008362 G5 box; other site 1100841008363 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 1100841008364 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 1100841008365 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 1100841008366 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1100841008367 active site 1100841008368 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 1100841008369 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1100841008370 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1100841008371 protein binding site [polypeptide binding]; other site 1100841008372 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1100841008373 protein binding site [polypeptide binding]; other site 1100841008374 L-aspartate oxidase; Provisional; Region: PRK09077 1100841008375 L-aspartate oxidase; Provisional; Region: PRK06175 1100841008376 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1100841008377 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1100841008378 CoenzymeA binding site [chemical binding]; other site 1100841008379 subunit interaction site [polypeptide binding]; other site 1100841008380 PHB binding site; other site 1100841008381 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 1100841008382 thymidylate kinase; Validated; Region: tmk; PRK00698 1100841008383 TMP-binding site; other site 1100841008384 ATP-binding site [chemical binding]; other site 1100841008385 YceG-like family; Region: YceG; pfam02618 1100841008386 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 1100841008387 dimerization interface [polypeptide binding]; other site 1100841008388 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 1100841008389 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 1100841008390 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1100841008391 catalytic residue [active] 1100841008392 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1100841008393 substrate binding pocket [chemical binding]; other site 1100841008394 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 1100841008395 membrane-bound complex binding site; other site 1100841008396 hinge residues; other site 1100841008397 Serine hydrolase; Region: Ser_hydrolase; pfam06821 1100841008398 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1100841008399 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 1100841008400 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1100841008401 dimer interface [polypeptide binding]; other site 1100841008402 conserved gate region; other site 1100841008403 putative PBP binding loops; other site 1100841008404 ABC-ATPase subunit interface; other site 1100841008405 sulfate transport protein; Provisional; Region: cysT; CHL00187 1100841008406 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1100841008407 dimer interface [polypeptide binding]; other site 1100841008408 conserved gate region; other site 1100841008409 putative PBP binding loops; other site 1100841008410 ABC-ATPase subunit interface; other site 1100841008411 ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118 1100841008412 ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296 1100841008413 Walker A/P-loop; other site 1100841008414 ATP binding site [chemical binding]; other site 1100841008415 Q-loop/lid; other site 1100841008416 ABC transporter signature motif; other site 1100841008417 Walker B; other site 1100841008418 D-loop; other site 1100841008419 H-loop/switch region; other site 1100841008420 TOBE-like domain; Region: TOBE_3; pfam12857 1100841008421 transcriptional regulator CysB-like protein; Reviewed; Region: PRK12683 1100841008422 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1100841008423 The C-terminal substrate domain of LysR-type transcriptional regulators CysB-like contains type 2 periplasmic binding fold; Region: PBP2_CysB_like; cd08413 1100841008424 substrate binding site [chemical binding]; other site 1100841008425 dimerization interface [polypeptide binding]; other site 1100841008426 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830 1100841008427 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 1100841008428 active site 1100841008429 substrate binding site [chemical binding]; other site 1100841008430 trimer interface [polypeptide binding]; other site 1100841008431 CoA binding site [chemical binding]; other site 1100841008432 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE, gammaproteobacterial type; Region: rSAM_QueE_gams; TIGR04349 1100841008433 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1100841008434 FeS/SAM binding site; other site 1100841008435 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 1100841008436 Ligand Binding Site [chemical binding]; other site 1100841008437 Predicted ATPases of PP-loop superfamily [General function prediction only]; Region: COG2102 1100841008438 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_IV; cd01994 1100841008439 Ligand Binding Site [chemical binding]; other site 1100841008440 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 1100841008441 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 1100841008442 catalytic triad [active] 1100841008443 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 1100841008444 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 1100841008445 nicotinamide-nucleotide adenylyltransferase; Provisional; Region: PRK13793 1100841008446 active site 1100841008447 nucleotide binding site [chemical binding]; other site 1100841008448 HIGH motif; other site 1100841008449 KMSKS motif; other site 1100841008450 enoyl-CoA hydratase; Provisional; Region: PRK06688 1100841008451 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1100841008452 substrate binding site [chemical binding]; other site 1100841008453 oxyanion hole (OAH) forming residues; other site 1100841008454 trimer interface [polypeptide binding]; other site 1100841008455 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 1100841008456 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1100841008457 putative substrate translocation pore; other site 1100841008458 phosphoribosylformylglycinamidine synthase; Provisional; Region: PRK05297 1100841008459 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 1100841008460 dimerization interface [polypeptide binding]; other site 1100841008461 ATP binding site [chemical binding]; other site 1100841008462 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 1100841008463 dimerization interface [polypeptide binding]; other site 1100841008464 ATP binding site [chemical binding]; other site 1100841008465 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 1100841008466 putative active site [active] 1100841008467 catalytic triad [active] 1100841008468 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01096 1100841008469 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1100841008470 Zn2+ binding site [ion binding]; other site 1100841008471 Mg2+ binding site [ion binding]; other site 1100841008472 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 1100841008473 RuvA N terminal domain; Region: RuvA_N; pfam01330 1100841008474 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 1100841008475 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 1100841008476 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 1100841008477 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1100841008478 Walker A motif; other site 1100841008479 ATP binding site [chemical binding]; other site 1100841008480 Walker B motif; other site 1100841008481 arginine finger; other site 1100841008482 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 1100841008483 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like2; cd05667 1100841008484 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1100841008485 metal binding site [ion binding]; metal-binding site 1100841008486 putative dimer interface [polypeptide binding]; other site 1100841008487 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1100841008488 active site 1100841008489 TolQ protein; Region: tolQ; TIGR02796 1100841008490 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 1100841008491 TolR protein; Region: tolR; TIGR02801 1100841008492 TolA protein; Region: tolA_full; TIGR02794 1100841008493 TonB C terminal; Region: TonB_2; pfam13103 1100841008494 translocation protein TolB; Provisional; Region: tolB; PRK04922 1100841008495 TolB amino-terminal domain; Region: TolB_N; pfam04052 1100841008496 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 1100841008497 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 1100841008498 putative outer membrane lipoprotein; Provisional; Region: PRK09967 1100841008499 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1100841008500 ligand binding site [chemical binding]; other site 1100841008501 fructose-1,6-bisphosphatase family protein; Region: PLN02628 1100841008502 Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354 1100841008503 AMP binding site [chemical binding]; other site 1100841008504 metal binding site [ion binding]; metal-binding site 1100841008505 active site 1100841008506 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 1100841008507 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1100841008508 RNA polymerase factor sigma-70; Validated; Region: PRK09047 1100841008509 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1100841008510 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1100841008511 DNA binding residues [nucleotide binding] 1100841008512 Protein of unknown function (DUF3106); Region: DUF3106; pfam11304 1100841008513 Acinetobacter rhombotarget A; Region: GlyGly_RbtA; TIGR04212 1100841008514 CSLREA domain; Region: CSLREA_Nterm; TIGR04214 1100841008515 Acinetobacter rhombotarget A; Region: GlyGly_RbtA; TIGR04212 1100841008516 CSLREA domain; Region: CSLREA_Nterm; TIGR04214 1100841008517 ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593 1100841008518 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1100841008519 Walker A motif; other site 1100841008520 ATP binding site [chemical binding]; other site 1100841008521 Walker B motif; other site 1100841008522 arginine finger; other site 1100841008523 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1100841008524 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1100841008525 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 1100841008526 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 1100841008527 dimerization interface [polypeptide binding]; other site 1100841008528 putative ATP binding site [chemical binding]; other site 1100841008529 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 1100841008530 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 1100841008531 active site 1100841008532 substrate binding site [chemical binding]; other site 1100841008533 cosubstrate binding site; other site 1100841008534 catalytic site [active] 1100841008535 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1100841008536 Periplasmic serine proteases (ClpP class) [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: SppA; COG0616 1100841008537 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 1100841008538 tandem repeat interface [polypeptide binding]; other site 1100841008539 oligomer interface [polypeptide binding]; other site 1100841008540 active site residues [active] 1100841008541 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 1100841008542 putative acyl-acceptor binding pocket; other site 1100841008543 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 1100841008544 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 1100841008545 Competence protein; Region: Competence; pfam03772 1100841008546 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 1100841008547 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1100841008548 lipoprotein releasing system, ATP-binding protein; Region: LolD_lipo_ex; TIGR02211 1100841008549 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1100841008550 Walker A/P-loop; other site 1100841008551 ATP binding site [chemical binding]; other site 1100841008552 Q-loop/lid; other site 1100841008553 ABC transporter signature motif; other site 1100841008554 Walker B; other site 1100841008555 D-loop; other site 1100841008556 H-loop/switch region; other site 1100841008557 lipoprotein releasing system, transmembrane protein, LolC/E family; Region: lolCE; TIGR02212 1100841008558 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1100841008559 FtsX-like permease family; Region: FtsX; pfam02687 1100841008560 putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272 1100841008561 EamA-like transporter family; Region: EamA; pfam00892 1100841008562 Uncharacterized BCR, YaiI/YqxD family COG1671; Region: DUF188; pfam02639 1100841008563 Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT). PSAT is active as...; Region: PSAT_like; cd00611 1100841008564 homodimer interface [polypeptide binding]; other site 1100841008565 substrate-cofactor binding pocket; other site 1100841008566 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1100841008567 catalytic residue [active] 1100841008568 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 1100841008569 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 1100841008570 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1100841008571 HlyD family secretion protein; Region: HlyD_3; pfam13437 1100841008572 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 1100841008573 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1100841008574 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 1100841008575 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1100841008576 uncharacterized YdjC-like family proteins from bacteria; Region: YdjC_like_3; cd10807 1100841008577 putative active site [active] 1100841008578 YdjC motif; other site 1100841008579 Mg binding site [ion binding]; other site 1100841008580 putative homodimer interface [polypeptide binding]; other site 1100841008581 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 1100841008582 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 1100841008583 Ligand binding site; other site 1100841008584 Putative Catalytic site; other site 1100841008585 DXD motif; other site 1100841008586 GtrA-like protein; Region: GtrA; pfam04138 1100841008587 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 1100841008588 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 1100841008589 DNA gyrase subunit A; Validated; Region: PRK05560 1100841008590 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 1100841008591 CAP-like domain; other site 1100841008592 active site 1100841008593 primary dimer interface [polypeptide binding]; other site 1100841008594 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1100841008595 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1100841008596 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1100841008597 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1100841008598 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1100841008599 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1100841008600 electron transfer flavoprotein subunit alpha; Provisional; Region: PLN00022 1100841008601 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 1100841008602 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 1100841008603 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 1100841008604 Ligand binding site [chemical binding]; other site 1100841008605 Electron transfer flavoprotein domain; Region: ETF; pfam01012 1100841008606 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 1100841008607 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1100841008608 active site 1100841008609 DNA binding site [nucleotide binding] 1100841008610 Int/Topo IB signature motif; other site 1100841008611 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 1100841008612 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 1100841008613 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 1100841008614 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 1100841008615 diaminopimelate decarboxylase; Region: lysA; TIGR01048 1100841008616 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 1100841008617 active site 1100841008618 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1100841008619 substrate binding site [chemical binding]; other site 1100841008620 catalytic residues [active] 1100841008621 dimer interface [polypeptide binding]; other site 1100841008622 D-alanine/D-serine/glycine permease; Provisional; Region: PRK11049 1100841008623 DNA repair protein RadA; Provisional; Region: PRK11823 1100841008624 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 1100841008625 Walker A motif/ATP binding site; other site 1100841008626 ATP binding site [chemical binding]; other site 1100841008627 Walker B motif; other site 1100841008628 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 1100841008629 Tim44 is an essential component of the machinery that mediates the translocation of nuclear-encoded proteins across the mitochondrial inner membrane; Region: Tim44; smart00978 1100841008630 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1100841008631 EF-P lysine aminoacylase GenX; Region: genX; TIGR00462 1100841008632 motif 1; other site 1100841008633 dimer interface [polypeptide binding]; other site 1100841008634 active site 1100841008635 motif 2; other site 1100841008636 motif 3; other site 1100841008637 erythronate-4-phosphate dehydrogenase; Validated; Region: PRK00257 1100841008638 D-Erythronate-4-Phosphate Dehydrogenase NAD-binding and catalytic domains; Region: ErythrP_dh; cd12158 1100841008639 ligand binding site [chemical binding]; other site 1100841008640 NAD binding site [chemical binding]; other site 1100841008641 catalytic site [active] 1100841008642 homodimer interface [polypeptide binding]; other site 1100841008643 Protein of unknown function (DUF1232); Region: DUF1232; cl01318 1100841008644 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 1100841008645 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1100841008646 molybdopterin cofactor binding site; other site 1100841008647 The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787 1100841008648 putative molybdopterin cofactor binding site; other site 1100841008649 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 1100841008650 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1100841008651 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1100841008652 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 1100841008653 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1100841008654 NAD(P) binding site [chemical binding]; other site 1100841008655 active site 1100841008656 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 1100841008657 dimer interface [polypeptide binding]; other site 1100841008658 FMN binding site [chemical binding]; other site 1100841008659 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1100841008660 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1100841008661 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687 1100841008662 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1100841008663 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1100841008664 The adenylation (A) domain of siderophore-synthesizing nonribosomal peptide synthetases (NRPS); Region: A_NRPS_SidN3_like; cd05918 1100841008665 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 1100841008666 acyl-activating enzyme (AAE) consensus motif; other site 1100841008667 AMP binding site [chemical binding]; other site 1100841008668 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1100841008669 non-ribosomal peptide synthetase terminal domain of unknown function; Region: NRPS_term_dom; TIGR02353 1100841008670 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 1100841008671 putative trimer interface [polypeptide binding]; other site 1100841008672 putative CoA binding site [chemical binding]; other site 1100841008673 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 1100841008674 putative CoA binding site [chemical binding]; other site 1100841008675 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 1100841008676 Calcium/calmodulin dependent protein kinase II Association; Region: CaMKII_AD; cl17504 1100841008677 transcription elongation factor GreB; Reviewed; Region: greB; PRK01885 1100841008678 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 1100841008679 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 1100841008680 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1100841008681 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1100841008682 catalytic residue [active] 1100841008683 SCP-2 sterol transfer family; Region: SCP2; pfam02036 1100841008684 tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696 1100841008685 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 1100841008686 Ligand Binding Site [chemical binding]; other site 1100841008687 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 1100841008688 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1100841008689 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1100841008690 catalytic residue [active] 1100841008691 heat shock protein HtpX; Provisional; Region: PRK05457 1100841008692 Domain of unknown function (DUF4112); Region: DUF4112; pfam13430 1100841008693 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 1100841008694 Protein export membrane protein; Region: SecD_SecF; cl14618 1100841008695 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 1100841008696 Glycerophosphodiester phosphodiesterase domain of Streptomycin coelicolor (GlpQ1) and similar proteins; Region: GDPD_ScGlpQ1_like; cd08602 1100841008697 putative active site [active] 1100841008698 catalytic site [active] 1100841008699 putative metal binding site [ion binding]; other site 1100841008700 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1100841008701 Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818 1100841008702 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 1100841008703 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 1100841008704 ring oligomerisation interface [polypeptide binding]; other site 1100841008705 ATP/Mg binding site [chemical binding]; other site 1100841008706 stacking interactions; other site 1100841008707 hinge regions; other site 1100841008708 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 1100841008709 oligomerisation interface [polypeptide binding]; other site 1100841008710 mobile loop; other site 1100841008711 roof hairpin; other site 1100841008712 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1100841008713 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 1100841008714 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1100841008715 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1100841008716 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 1100841008717 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1100841008718 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1100841008719 type I secretion C-terminal target domain (VC_A0849 subclass); Region: T1SS_VCA0849; TIGR03661 1100841008720 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1100841008721 Bacillus subtilis YydB and related proteins, metallophosphatase domain; Region: MPP_YydB; cd07400 1100841008722 putative active site [active] 1100841008723 putative metal binding site [ion binding]; other site 1100841008724 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1100841008725 active site 1100841008726 metal binding site [ion binding]; metal-binding site 1100841008727 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 1100841008728 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 1100841008729 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819 1100841008730 active site 1100841008731 substrate-binding site [chemical binding]; other site 1100841008732 metal-binding site [ion binding] 1100841008733 GTP binding site [chemical binding]; other site 1100841008734 glycerol-3-phosphate dehydrogenase; Reviewed; Region: glpD; PRK12266 1100841008735 glycerol kinase; Provisional; Region: glpK; PRK00047 1100841008736 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 1100841008737 N- and C-terminal domain interface [polypeptide binding]; other site 1100841008738 active site 1100841008739 MgATP binding site [chemical binding]; other site 1100841008740 catalytic site [active] 1100841008741 metal binding site [ion binding]; metal-binding site 1100841008742 glycerol binding site [chemical binding]; other site 1100841008743 homotetramer interface [polypeptide binding]; other site 1100841008744 homodimer interface [polypeptide binding]; other site 1100841008745 FBP binding site [chemical binding]; other site 1100841008746 protein IIAGlc interface [polypeptide binding]; other site 1100841008747 alpha-ketoglutarate transporter; Provisional; Region: PRK10406 1100841008748 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1100841008749 putative substrate translocation pore; other site 1100841008750 Predicted methyltransferase [General function prediction only]; Region: COG3897 1100841008751 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1100841008752 S-adenosylmethionine binding site [chemical binding]; other site 1100841008753 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 1100841008754 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 1100841008755 homodimer interface [polypeptide binding]; other site 1100841008756 NADP binding site [chemical binding]; other site 1100841008757 substrate binding site [chemical binding]; other site 1100841008758 PhoD-like phosphatase; Region: PhoD; pfam09423 1100841008759 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 1100841008760 putative active site [active] 1100841008761 putative metal binding site [ion binding]; other site 1100841008762 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 1100841008763 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 1100841008764 dihydropteroate synthase; Region: DHPS; TIGR01496 1100841008765 substrate binding pocket [chemical binding]; other site 1100841008766 dimer interface [polypeptide binding]; other site 1100841008767 inhibitor binding site; inhibition site 1100841008768 FtsH Extracellular; Region: FtsH_ext; pfam06480 1100841008769 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 1100841008770 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1100841008771 Walker A motif; other site 1100841008772 ATP binding site [chemical binding]; other site 1100841008773 Walker B motif; other site 1100841008774 arginine finger; other site 1100841008775 Peptidase family M41; Region: Peptidase_M41; pfam01434 1100841008776 FtsJ-like methyltransferase; Region: FtsJ; cl17430 1100841008777 23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293 1100841008778 Escherichia coli YhbY is associated with pre-50S ribosomal subunits, which implies a function in ribosome assembly; Region: CRS1_YhbY; smart01103 1100841008779 Domon-like domain of UDP-N-acetylenolpyruvoylglucosamine reductase; Region: DOMON_murB_like; cd09627 1100841008780 putative heme binding site [chemical binding]; other site 1100841008781 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 1100841008782 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 1100841008783 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 1100841008784 catalytic site [active] 1100841008785 subunit interface [polypeptide binding]; other site 1100841008786 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 1100841008787 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1100841008788 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1100841008789 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 1100841008790 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1100841008791 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1100841008792 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 1100841008793 IMP binding site; other site 1100841008794 dimer interface [polypeptide binding]; other site 1100841008795 interdomain contacts; other site 1100841008796 partial ornithine binding site; other site 1100841008797 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 1100841008798 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 1100841008799 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 1100841008800 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 1100841008801 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 1100841008802 trimer interface [polypeptide binding]; other site 1100841008803 active site 1100841008804 substrate binding site [chemical binding]; other site 1100841008805 CoA binding site [chemical binding]; other site 1100841008806 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1100841008807 Ligand Binding Site [chemical binding]; other site 1100841008808 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1100841008809 DNA binding site [nucleotide binding] 1100841008810 active site 1100841008811 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 1100841008812 active site 1100841008813 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 1100841008814 putative active site [active] 1100841008815 putative metal binding site [ion binding]; other site 1100841008816 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 1100841008817 type 2 lantibiotic biosynthesis protein LanM; Region: lanti_2_LanM; TIGR03897 1100841008818 type I secretion C-terminal target domain (VC_A0849 subclass); Region: T1SS_VCA0849; TIGR03661 1100841008819 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 1100841008820 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1100841008821 active site 1100841008822 DNA binding site [nucleotide binding] 1100841008823 Int/Topo IB signature motif; other site 1100841008824 AAA domain; Region: AAA_33; pfam13671 1100841008825 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4185 1100841008826 Protein of unknown function (DUF2663); Region: DUF2663; pfam10864 1100841008827 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 1100841008828 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 1100841008829 Predicted metalloprotease [General function prediction only]; Region: COG2321 1100841008830 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 1100841008831 Protein of unknown function (DUF808); Region: DUF808; pfam05661 1100841008832 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 1100841008833 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 1100841008834 active site 1100841008835 HIGH motif; other site 1100841008836 dimer interface [polypeptide binding]; other site 1100841008837 KMSKS motif; other site 1100841008838 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 1100841008839 CoA binding domain; Region: CoA_binding; smart00881 1100841008840 CoA-ligase; Region: Ligase_CoA; pfam00549 1100841008841 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 1100841008842 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 1100841008843 CoA-ligase; Region: Ligase_CoA; pfam00549 1100841008844 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06467 1100841008845 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1100841008846 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1100841008847 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1100841008848 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 1100841008849 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1100841008850 E3 interaction surface; other site 1100841008851 lipoyl attachment site [posttranslational modification]; other site 1100841008852 e3 binding domain; Region: E3_binding; pfam02817 1100841008853 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1100841008854 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 1100841008855 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 1100841008856 TPP-binding site [chemical binding]; other site 1100841008857 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 1100841008858 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 1100841008859 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 1100841008860 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07057 1100841008861 L-aspartate oxidase; Provisional; Region: PRK06175 1100841008862 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1100841008863 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. E. coli SQR, a member of this subfamily, reduces the...; Region: SQR_TypeC_SdhD; cd03494 1100841008864 SdhC subunit interface [polypeptide binding]; other site 1100841008865 proximal heme binding site [chemical binding]; other site 1100841008866 cardiolipin binding site; other site 1100841008867 Iron-sulfur protein interface; other site 1100841008868 proximal quinone binding site [chemical binding]; other site 1100841008869 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499 1100841008870 proximal quinone binding site [chemical binding]; other site 1100841008871 SdhD (CybS) interface [polypeptide binding]; other site 1100841008872 proximal heme binding site [chemical binding]; other site 1100841008873 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 1100841008874 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 1100841008875 dimer interface [polypeptide binding]; other site 1100841008876 active site 1100841008877 citrylCoA binding site [chemical binding]; other site 1100841008878 NADH binding [chemical binding]; other site 1100841008879 cationic pore residues; other site 1100841008880 oxalacetate/citrate binding site [chemical binding]; other site 1100841008881 coenzyme A binding site [chemical binding]; other site 1100841008882 catalytic triad [active] 1100841008883 Protein of unknown function (DUF1289); Region: DUF1289; pfam06945 1100841008884 Predicted sulfurtransferase [General function prediction only]; Region: COG1054 1100841008885 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 1100841008886 active site residue [active] 1100841008887 Uncharacterized protein family (UPF0149); Region: UPF0149; pfam03695 1100841008888 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 1100841008889 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 1100841008890 Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546 1100841008891 RNA polymerase sigma factor RpoD, C-terminal domain; Region: RpoD_Cterm; TIGR02393 1100841008892 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1100841008893 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1100841008894 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1100841008895 DNA binding residues [nucleotide binding] 1100841008896 Protein of unknown function (DUF493); Region: DUF493; pfam04359 1100841008897 lipoate-protein ligase B; Provisional; Region: PRK14342 1100841008898 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 1100841008899 Iron-containing alcohol dehydrogenases-like; Region: Fe-ADH5; cd08189 1100841008900 putative active site [active] 1100841008901 metal binding site [ion binding]; metal-binding site 1100841008902 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 1100841008903 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 1100841008904 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1100841008905 Predicted transcriptional regulators [Transcription]; Region: COG1733 1100841008906 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1100841008907 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 1100841008908 Sirohaem synthase dimerisation region; Region: CysG_dimeriser; pfam10414 1100841008909 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 1100841008910 active site 1100841008911 SAM binding site [chemical binding]; other site 1100841008912 homodimer interface [polypeptide binding]; other site 1100841008913 seryl-tRNA synthetase; Provisional; Region: PRK05431 1100841008914 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 1100841008915 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 1100841008916 dimer interface [polypeptide binding]; other site 1100841008917 active site 1100841008918 motif 1; other site 1100841008919 motif 2; other site 1100841008920 motif 3; other site 1100841008921 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 1100841008922 lipoprotein chaperone; Reviewed; Region: lolA; PRK00031 1100841008923 Outer membrane lipoprotein carrier protein LolA; Region: LolA; pfam03548 1100841008924 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 1100841008925 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 1100841008926 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 1100841008927 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1100841008928 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1100841008929 substrate binding pocket [chemical binding]; other site 1100841008930 chain length determination region; other site 1100841008931 substrate-Mg2+ binding site; other site 1100841008932 catalytic residues [active] 1100841008933 aspartate-rich region 1; other site 1100841008934 active site lid residues [active] 1100841008935 aspartate-rich region 2; other site 1100841008936 Site-specific recombinase; Region: SpecificRecomb; pfam10136 1100841008937 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 1100841008938 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 1100841008939 active site 1100841008940 multidrug efflux system transporter AcrA; Provisional; Region: PRK15030 1100841008941 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1100841008942 HlyD family secretion protein; Region: HlyD_3; pfam13437 1100841008943 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 1100841008944 Protein export membrane protein; Region: SecD_SecF; cl14618 1100841008945 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 1100841008946 Putative heavy-metal-binding; Region: YbjQ_1; cl00426 1100841008947 Uncharacterized conserved protein [Function unknown]; Region: COG0393 1100841008948 SnoaL-like domain; Region: SnoaL_4; pfam13577 1100841008949 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1100841008950 short chain dehydrogenase; Provisional; Region: PRK06181 1100841008951 NAD(P) binding site [chemical binding]; other site 1100841008952 active site 1100841008953 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 1100841008954 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 1100841008955 HIGH motif; other site 1100841008956 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1100841008957 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 1100841008958 active site 1100841008959 KMSKS motif; other site 1100841008960 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 1100841008961 tRNA binding surface [nucleotide binding]; other site 1100841008962 anticodon binding site; other site 1100841008963 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 1100841008964 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1100841008965 S-adenosylmethionine binding site [chemical binding]; other site 1100841008966 Predicted permeases [General function prediction only]; Region: COG0679 1100841008967 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1100841008968 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1100841008969 putative DNA binding site [nucleotide binding]; other site 1100841008970 putative Zn2+ binding site [ion binding]; other site 1100841008971 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1100841008972 dimerization interface [polypeptide binding]; other site 1100841008973 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 1100841008974 PAP2_like_6 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which mainly contains bacterial proteins, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_6; cd03396 1100841008975 active site 1100841008976 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1100841008977 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1100841008978 dimer interface [polypeptide binding]; other site 1100841008979 phosphorylation site [posttranslational modification] 1100841008980 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1100841008981 ATP binding site [chemical binding]; other site 1100841008982 Mg2+ binding site [ion binding]; other site 1100841008983 G-X-G motif; other site 1100841008984 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1100841008985 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1100841008986 active site 1100841008987 phosphorylation site [posttranslational modification] 1100841008988 intermolecular recognition site; other site 1100841008989 dimerization interface [polypeptide binding]; other site 1100841008990 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1100841008991 DNA binding site [nucleotide binding] 1100841008992 putative metal dependent hydrolase; Provisional; Region: PRK11598 1100841008993 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 1100841008994 Sulfatase; Region: Sulfatase; pfam00884 1100841008995 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 1100841008996 muropeptide transporter; Validated; Region: ampG; cl17669 1100841008997 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1100841008998 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown ABO13168; Region: LPLAT_ABO13168-like; cd07988 1100841008999 putative acyl-acceptor binding pocket; other site 1100841009000 hypothetical protein; Provisional; Region: PRK10279 1100841009001 Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205 1100841009002 nucleophile elbow; other site 1100841009003 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 1100841009004 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 1100841009005 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 1100841009006 Protein of unknown function (DUF419); Region: DUF419; cl15265 1100841009007 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1100841009008 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1100841009009 substrate binding pocket [chemical binding]; other site 1100841009010 chain length determination region; other site 1100841009011 substrate-Mg2+ binding site; other site 1100841009012 catalytic residues [active] 1100841009013 aspartate-rich region 1; other site 1100841009014 active site lid residues [active] 1100841009015 aspartate-rich region 2; other site 1100841009016 probable AcnD-accessory protein PrpF; Region: prpF; TIGR02334 1100841009017 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 1100841009018 chaperone protein HchA; Provisional; Region: PRK04155 1100841009019 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 1100841009020 conserved cys residue [active] 1100841009021 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 1100841009022 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 1100841009023 NAD(P) binding site [chemical binding]; other site 1100841009024 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 1100841009025 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1100841009026 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1100841009027 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1100841009028 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 1100841009029 Mrr N-terminal domain; Region: Mrr_N; pfam14338 1100841009030 PaaX-like protein C-terminal domain; Region: PaaX_C; pfam08223 1100841009031 This CD includes the dihydrorhizobitoxine fatty acid desaturase (RtxC) characterized in Bradyrhizobium japonicum USDA110, and other related proteins. Dihydrorhizobitoxine desaturase is reported to be involved in the final step of rhizobitoxine...; Region: Rhizobitoxine-FADS-like; cd03510 1100841009032 putative di-iron ligands [ion binding]; other site 1100841009033 This CD includes the dihydrorhizobitoxine fatty acid desaturase (RtxC) characterized in Bradyrhizobium japonicum USDA110, and other related proteins. Dihydrorhizobitoxine desaturase is reported to be involved in the final step of rhizobitoxine...; Region: Rhizobitoxine-FADS-like; cd03510 1100841009034 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 1100841009035 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1100841009036 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1100841009037 Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525 1100841009038 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1100841009039 Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; cl17479 1100841009040 Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; cl17479 1100841009041 phosphoserine phosphatase; Provisional; Region: thrH; PRK13582 1100841009042 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 1100841009043 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 1100841009044 Active Sites [active] 1100841009045 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 1100841009046 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 1100841009047 ribonuclease G; Provisional; Region: PRK11712 1100841009048 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 1100841009049 homodimer interface [polypeptide binding]; other site 1100841009050 oligonucleotide binding site [chemical binding]; other site 1100841009051 Maf-like protein; Region: Maf; pfam02545 1100841009052 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 1100841009053 active site 1100841009054 dimer interface [polypeptide binding]; other site 1100841009055 rod shape-determining protein MreD; Region: shape_MreD; TIGR03426 1100841009056 rod shape-determining protein MreC; Provisional; Region: PRK13922 1100841009057 rod shape-determining protein MreC; Region: MreC; pfam04085 1100841009058 rod shape-determining protein MreB; Provisional; Region: PRK13927 1100841009059 MreB and similar proteins; Region: MreB_like; cd10225 1100841009060 putative protofilament interaction site [polypeptide binding]; other site 1100841009061 nucleotide binding site [chemical binding]; other site 1100841009062 RodZ interaction site [polypeptide binding]; other site 1100841009063 Mg binding site [ion binding]; other site 1100841009064 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 1100841009065 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 1100841009066 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 1100841009067 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 1100841009068 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 1100841009069 GatB domain; Region: GatB_Yqey; smart00845 1100841009070 intracellular protease, PfpI family; Region: PfpI; TIGR01382 1100841009071 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_1; cd03169 1100841009072 conserved cys residue [active] 1100841009073 Protein of unknown function (DUF1176); Region: DUF1176; pfam06674 1100841009074 microcin B17 transporter; Reviewed; Region: PRK11098 1100841009075 threonine dehydratase; Provisional; Region: PRK07334 1100841009076 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 1100841009077 tetramer interface [polypeptide binding]; other site 1100841009078 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1100841009079 catalytic residue [active] 1100841009080 C-terminal ACT domain of biodegradative (catabolic) threonine dehydratase II (ThrD-II) and other related ACT domains; Region: ACT_ThrD-II-like; cd04886 1100841009081 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 1100841009082 Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205 1100841009083 active site 1100841009084 nucleophile elbow; other site 1100841009085 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 1100841009086 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 1100841009087 Nitroreductase family. Members of this family utilize FMN as a cofactor and catalyze reduction of a variety of nitroaromatic compounds, including nitrofurans, nitrobenzens, nitrophenol, nitrobenzoate and quinones by using either NADH or NADPH as a source...; Region: Nitroreductase; cd02136 1100841009088 putative FMN binding site [chemical binding]; other site 1100841009089 bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102 1100841009090 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1100841009091 putative substrate translocation pore; other site 1100841009092 FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805 1100841009093 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 1100841009094 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 1100841009095 YcxB-like protein; Region: YcxB; pfam14317 1100841009096 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 1100841009097 PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172 1100841009098 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 1100841009099 Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; Region: CysJ; COG0369 1100841009100 Flavodoxin; Region: Flavodoxin_1; pfam00258 1100841009101 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR_like1; cd06200 1100841009102 FAD binding pocket [chemical binding]; other site 1100841009103 FAD binding motif [chemical binding]; other site 1100841009104 catalytic residues [active] 1100841009105 NAD binding pocket [chemical binding]; other site 1100841009106 phosphate binding motif [ion binding]; other site 1100841009107 beta-alpha-beta structure motif; other site 1100841009108 Uncharacterized conserved protein [Function unknown]; Region: COG1434 1100841009109 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 1100841009110 putative active site [active] 1100841009111 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 1100841009112 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1100841009113 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2832 1100841009114 Domain of unknown function (DUF1853); Region: DUF1853; cl01545 1100841009115 Predicted small secreted protein [Function unknown]; Region: COG5510 1100841009116 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009 1100841009117 M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891 1100841009118 metal binding site [ion binding]; metal-binding site 1100841009119 dimer interface [polypeptide binding]; other site 1100841009120 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1100841009121 putative binding surface; other site 1100841009122 active site 1100841009123 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1100841009124 putative binding surface; other site 1100841009125 active site 1100841009126 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1100841009127 putative binding surface; other site 1100841009128 active site 1100841009129 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1100841009130 putative binding surface; other site 1100841009131 active site 1100841009132 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 1100841009133 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 1100841009134 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1100841009135 ATP binding site [chemical binding]; other site 1100841009136 Mg2+ binding site [ion binding]; other site 1100841009137 G-X-G motif; other site 1100841009138 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 1100841009139 Response regulator receiver domain; Region: Response_reg; pfam00072 1100841009140 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1100841009141 active site 1100841009142 phosphorylation site [posttranslational modification] 1100841009143 intermolecular recognition site; other site 1100841009144 dimerization interface [polypeptide binding]; other site 1100841009145 Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675 1100841009146 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1100841009147 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1100841009148 dimer interface [polypeptide binding]; other site 1100841009149 putative CheW interface [polypeptide binding]; other site 1100841009150 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 1100841009151 Response regulator receiver domain; Region: Response_reg; pfam00072 1100841009152 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1100841009153 active site 1100841009154 phosphorylation site [posttranslational modification] 1100841009155 intermolecular recognition site; other site 1100841009156 dimerization interface [polypeptide binding]; other site 1100841009157 Response regulator receiver domain; Region: Response_reg; pfam00072 1100841009158 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1100841009159 active site 1100841009160 phosphorylation site [posttranslational modification] 1100841009161 intermolecular recognition site; other site 1100841009162 dimerization interface [polypeptide binding]; other site 1100841009163 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1100841009164 HlyD family secretion protein; Region: HlyD_3; pfam13437 1100841009165 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 1100841009166 prolyl-tRNA synthetase; Provisional; Region: PRK09194 1100841009167 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 1100841009168 dimer interface [polypeptide binding]; other site 1100841009169 motif 1; other site 1100841009170 active site 1100841009171 motif 2; other site 1100841009172 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 1100841009173 putative deacylase active site [active] 1100841009174 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1100841009175 active site 1100841009176 motif 3; other site 1100841009177 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 1100841009178 anticodon binding site; other site 1100841009179 Uncharacterized conserved protein [Function unknown]; Region: COG3422 1100841009180 Domain of unknown function (DUF1508); Region: DUF1508; pfam07411 1100841009181 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 1100841009182 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 1100841009183 PhnA protein; Region: PhnA; pfam03831 1100841009184 Uncharacterized conserved protein [Function unknown]; Region: COG3189 1100841009185 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_2; cd08895 1100841009186 putative hydrophobic ligand binding site [chemical binding]; other site 1100841009187 Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354 1100841009188 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 1100841009189 protein disulfide isomerase II DsbC; Provisional; Region: PRK10877 1100841009190 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020 1100841009191 dimerization domain [polypeptide binding]; other site 1100841009192 dimer interface [polypeptide binding]; other site 1100841009193 catalytic residues [active] 1100841009194 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 1100841009195 Sel1-like repeats; Region: SEL1; smart00671 1100841009196 Predicted permeases [General function prediction only]; Region: COG0679 1100841009197 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1100841009198 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 1100841009199 active site 1100841009200 FMN binding site [chemical binding]; other site 1100841009201 substrate binding site [chemical binding]; other site 1100841009202 homotetramer interface [polypeptide binding]; other site 1100841009203 catalytic residue [active] 1100841009204 TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786 1100841009205 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1100841009206 N-terminal plug; other site 1100841009207 ligand-binding site [chemical binding]; other site 1100841009208 Predicted metalloprotease [General function prediction only]; Region: COG2321 1100841009209 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 1100841009210 Protein of unknown function (DUF808); Region: DUF808; pfam05661 1100841009211 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 1100841009212 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 1100841009213 active site 1100841009214 HIGH motif; other site 1100841009215 dimer interface [polypeptide binding]; other site 1100841009216 KMSKS motif; other site 1100841009217 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 1100841009218 CoA binding domain; Region: CoA_binding; smart00881 1100841009219 CoA-ligase; Region: Ligase_CoA; pfam00549 1100841009220 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 1100841009221 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 1100841009222 CoA-ligase; Region: Ligase_CoA; pfam00549 1100841009223 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06467 1100841009224 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1100841009225 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1100841009226 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1100841009227 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 1100841009228 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1100841009229 E3 interaction surface; other site 1100841009230 lipoyl attachment site [posttranslational modification]; other site 1100841009231 e3 binding domain; Region: E3_binding; pfam02817 1100841009232 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1100841009233 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 1100841009234 active site 1100841009235 DNA binding site [nucleotide binding] 1100841009236 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 1100841009237 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 1100841009238 DNA binding site [nucleotide binding] 1100841009239 catalytic residue [active] 1100841009240 H2TH interface [polypeptide binding]; other site 1100841009241 putative catalytic residues [active] 1100841009242 turnover-facilitating residue; other site 1100841009243 intercalation triad [nucleotide binding]; other site 1100841009244 8OG recognition residue [nucleotide binding]; other site 1100841009245 putative reading head residues; other site 1100841009246 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 1100841009247 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1100841009248 PPIC-type PPIASE domain; Region: Rotamase_2; cl08278 1100841009249 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 1100841009250 putative active site pocket [active] 1100841009251 dimerization interface [polypeptide binding]; other site 1100841009252 putative catalytic residue [active] 1100841009253 large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13952 1100841009254 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 1100841009255 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 1100841009256 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 1100841009257 G1 box; other site 1100841009258 putative GEF interaction site [polypeptide binding]; other site 1100841009259 GTP/Mg2+ binding site [chemical binding]; other site 1100841009260 Switch I region; other site 1100841009261 G2 box; other site 1100841009262 G3 box; other site 1100841009263 Switch II region; other site 1100841009264 G4 box; other site 1100841009265 G5 box; other site 1100841009266 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 1100841009267 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 1100841009268 Xanthine/uracil permeases [Nucleotide transport and metabolism]; Region: UraA; COG2233 1100841009269 16S ribosomal RNA m2G1207 methyltransferase; Provisional; Region: rsmC; PRK09489 1100841009270 Methyltransferase small domain N-terminal; Region: MTS_N; pfam08468 1100841009271 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1100841009272 S-adenosylmethionine binding site [chemical binding]; other site 1100841009273 lysine transporter; Provisional; Region: PRK10836 1100841009274 Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139 1100841009275 hypothetical protein; Reviewed; Region: PRK09588 1100841009276 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 1100841009277 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 1100841009278 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1100841009279 ligand binding site [chemical binding]; other site 1100841009280 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830 1100841009281 Type II transport protein GspH; Region: GspH; pfam12019 1100841009282 acetyl-CoA acetyltransferase; Provisional; Region: PRK06954 1100841009283 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1100841009284 dimer interface [polypeptide binding]; other site 1100841009285 active site 1100841009286 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1100841009287 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 1100841009288 dimer interface [polypeptide binding]; other site 1100841009289 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 1100841009290 Bacterial protein of unknown function (DUF934); Region: DUF934; pfam06073 1100841009291 Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155 1100841009292 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1100841009293 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1100841009294 membrane-bound PQQ-dependent dehydrogenase, glucose/quinate/shikimate family; Region: PQQ_membr_DH; TIGR03074 1100841009295 Membrane-bound PQQ-dependent glucose dehydrogenase; Region: PQQ_mGDH; cd10280 1100841009296 Trp docking motif [polypeptide binding]; other site 1100841009297 putative active site [active] 1100841009298 Carbohydrate-selective porin, OprB family; Region: OprB; cl17816 1100841009299 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1100841009300 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1100841009301 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 1100841009302 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1100841009303 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1100841009304 acetyl-CoA acetyltransferase; Validated; Region: PRK08242 1100841009305 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1100841009306 dimer interface [polypeptide binding]; other site 1100841009307 active site 1100841009308 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 1100841009309 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1100841009310 substrate binding site [chemical binding]; other site 1100841009311 oxyanion hole (OAH) forming residues; other site 1100841009312 trimer interface [polypeptide binding]; other site 1100841009313 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1100841009314 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1100841009315 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667 1100841009316 Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208 1100841009317 active site 1100841009318 nucleophile elbow; other site 1100841009319 Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; pfam13444 1100841009320 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1100841009321 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1100841009322 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1100841009323 S-adenosylmethionine binding site [chemical binding]; other site 1100841009324 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 1100841009325 Haemolysin-III related; Region: HlyIII; cl03831 1100841009326 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1100841009327 metabolite-proton symporter; Region: 2A0106; TIGR00883 1100841009328 putative substrate translocation pore; other site 1100841009329 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 1100841009330 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 1100841009331 SEC-C motif; Region: SEC-C; pfam02810 1100841009332 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 1100841009333 Peroxiredoxin (PRX) family, 1-cys PRX subfamily; composed of PRXs containing only one conserved cysteine, which serves as the peroxidatic cysteine. They are homodimeric thiol-specific antioxidant (TSA) proteins that confer a protective role in cells by...; Region: PRX_1cys; cd03016 1100841009334 dimer interface [polypeptide binding]; other site 1100841009335 decamer (pentamer of dimers) interface [polypeptide binding]; other site 1100841009336 catalytic triad [active] 1100841009337 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 1100841009338 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 1100841009339 active site 1100841009340 catalytic residues [active] 1100841009341 Sporulation related domain; Region: SPOR; cl10051 1100841009342 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 1100841009343 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1100841009344 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1100841009345 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 1100841009346 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 1100841009347 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 1100841009348 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 1100841009349 substrate binding site [chemical binding]; other site 1100841009350 active site 1100841009351 catalytic residues [active] 1100841009352 heterodimer interface [polypeptide binding]; other site 1100841009353 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 1100841009354 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1100841009355 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687 1100841009356 Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118 1100841009357 Protein of unknown function (DUF2804); Region: DUF2804; pfam10974 1100841009358 Domain of Unknown Function (DUF1543); Region: DUF1543; pfam07566 1100841009359 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 1100841009360 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 1100841009361 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1100841009362 catalytic residue [active] 1100841009363 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 1100841009364 active site 1100841009365 Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206 1100841009366 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1100841009367 N-terminal plug; other site 1100841009368 ligand-binding site [chemical binding]; other site 1100841009369 Cobalamin adenosyltransferase; Region: Cob_adeno_trans; pfam01923 1100841009370 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 1100841009371 Glycerophosphodiester phosphodiesterase domain as found in prokaryota and eukaryota, and similar proteins; Region: GDPD; cd08556 1100841009372 active site 1100841009373 catalytic site [active] 1100841009374 metal binding site [ion binding]; metal-binding site 1100841009375 META domain; Region: META; pfam03724 1100841009376 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 1100841009377 Fatty acid desaturase; Region: FA_desaturase; pfam00487 1100841009378 Di-iron ligands [ion binding]; other site 1100841009379 Uncharacterized conserved protein [Function unknown]; Region: COG0397 1100841009380 hypothetical protein; Validated; Region: PRK00029 1100841009381 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1100841009382 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1100841009383 active site 1100841009384 phosphorylation site [posttranslational modification] 1100841009385 intermolecular recognition site; other site 1100841009386 dimerization interface [polypeptide binding]; other site 1100841009387 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1100841009388 DNA binding site [nucleotide binding] 1100841009389 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1100841009390 dimerization interface [polypeptide binding]; other site 1100841009391 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1100841009392 dimer interface [polypeptide binding]; other site 1100841009393 phosphorylation site [posttranslational modification] 1100841009394 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1100841009395 ATP binding site [chemical binding]; other site 1100841009396 Mg2+ binding site [ion binding]; other site 1100841009397 G-X-G motif; other site 1100841009398 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 1100841009399 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 1100841009400 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1100841009401 active site 1100841009402 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 1100841009403 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 1100841009404 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 1100841009405 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1100841009406 active site 1100841009407 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 1100841009408 LysR family transcriptional regulator; Provisional; Region: PRK14997 1100841009409 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1100841009410 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1100841009411 putative effector binding pocket; other site 1100841009412 dimerization interface [polypeptide binding]; other site 1100841009413 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 1100841009414 GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057 1100841009415 C-terminal domain interface [polypeptide binding]; other site 1100841009416 GSH binding site (G-site) [chemical binding]; other site 1100841009417 dimer interface [polypeptide binding]; other site 1100841009418 C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188 1100841009419 dimer interface [polypeptide binding]; other site 1100841009420 substrate binding pocket (H-site) [chemical binding]; other site 1100841009421 N-terminal domain interface [polypeptide binding]; other site 1100841009422 Predicted membrane protein [Function unknown]; Region: COG3223 1100841009423 Domain of unknown function (DUF3315); Region: DUF3315; pfam11776 1100841009424 Putative catalytic domain, repeat 1, of uncharacterized phospholipase D-like proteins; Region: PLDc_unchar2_1; cd09129 1100841009425 putative active site [active] 1100841009426 putative catalytic site [active] 1100841009427 Putative catalytic domain, repeat 2, of uncharacterized phospholipase D-like proteins; Region: PLDc_unchar2_2; cd09130 1100841009428 PLD-like domain; Region: PLDc_2; pfam13091 1100841009429 putative active site [active] 1100841009430 putative catalytic site [active] 1100841009431 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 1100841009432 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1100841009433 N-terminal plug; other site 1100841009434 ligand-binding site [chemical binding]; other site 1100841009435 Domain of unknown function (DUF4184); Region: DUF4184; pfam13803 1100841009436 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 1100841009437 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 1100841009438 dimer interface [polypeptide binding]; other site 1100841009439 anticodon binding site; other site 1100841009440 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 1100841009441 homodimer interface [polypeptide binding]; other site 1100841009442 motif 1; other site 1100841009443 active site 1100841009444 motif 2; other site 1100841009445 GAD domain; Region: GAD; pfam02938 1100841009446 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1100841009447 active site 1100841009448 motif 3; other site 1100841009449 Protein of unknown function (DUF3184); Region: DUF3184; pfam11380 1100841009450 Glycosyltransferase family 25 [lipooligosaccharide (LOS) biosynthesis protein] is a family of glycosyltransferases involved in LOS biosynthesis. The members include the beta(1,4) galactosyltransferases: Lgt2 of Moraxella catarrhalis, LgtB and LgtE of...; Region: Glyco_transf_25; cd06532 1100841009451 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1100841009452 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1100841009453 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1100841009454 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 1100841009455 putative metal binding site; other site 1100841009456 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 1100841009457 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 1100841009458 putative active site [active] 1100841009459 putative metal binding site [ion binding]; other site 1100841009460 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 1100841009461 phosphorylation site [posttranslational modification] 1100841009462 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 1100841009463 Predicted nucleoside-diphosphate-sugar epimerase [Cell envelope biogenesis, outer membrane]; Region: COG3660 1100841009464 Mitochondrial fission ELM1; Region: Mito_fiss_Elm1; pfam06258 1100841009465 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 1100841009466 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 1100841009467 homodimer interface [polypeptide binding]; other site 1100841009468 substrate-cofactor binding pocket; other site 1100841009469 catalytic residue [active] 1100841009470 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Reviewed; Region: PRK11072 1100841009471 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 1100841009472 metal binding triad; other site 1100841009473 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 1100841009474 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 1100841009475 metal binding triad; other site 1100841009476 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1100841009477 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1100841009478 dimer interface [polypeptide binding]; other site 1100841009479 phosphorylation site [posttranslational modification] 1100841009480 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1100841009481 ATP binding site [chemical binding]; other site 1100841009482 Mg2+ binding site [ion binding]; other site 1100841009483 G-X-G motif; other site 1100841009484 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 1100841009485 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 1100841009486 LemA family; Region: LemA; cl00742 1100841009487 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 1100841009488 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 1100841009489 preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585 1100841009490 SecD export protein N-terminal TM region; Region: SecD-TM1; pfam13721 1100841009491 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 1100841009492 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 1100841009493 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 1100841009494 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 1100841009495 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 1100841009496 Protein export membrane protein; Region: SecD_SecF; pfam02355 1100841009497 phosphopantothenoylcysteine decarboxylase / phosphopantothenate--cysteine ligase; Region: coaBC_dfp; TIGR00521 1100841009498 Flavoprotein; Region: Flavoprotein; pfam02441 1100841009499 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 1100841009500 hypothetical protein; Reviewed; Region: PRK00024 1100841009501 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 1100841009502 MPN+ (JAMM) motif; other site 1100841009503 Zinc-binding site [ion binding]; other site 1100841009504 Bestrophin, RFP-TM, chloride channel; Region: Bestrophin; pfam01062 1100841009505 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 1100841009506 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 1100841009507 active site 1100841009508 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 1100841009509 Intracellular septation protein A; Region: IspA; pfam04279 1100841009510 YciI-like protein; Reviewed; Region: PRK11370 1100841009511 bifunctional tRNA (mnm(5)s(2)U34)-methyltransferase/FAD-dependent cmnm(5)s(2)U34 oxidoreductase; Reviewed; Region: mnmC; PRK01747 1100841009512 Uncharacterized conserved protein [Function unknown]; Region: COG4121 1100841009513 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1100841009514 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1100841009515 active site residue [active] 1100841009516 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 1100841009517 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 1100841009518 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1100841009519 CoenzymeA binding site [chemical binding]; other site 1100841009520 subunit interaction site [polypeptide binding]; other site 1100841009521 PHB binding site; other site 1100841009522 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 1100841009523 thioredoxin 2; Provisional; Region: PRK10996 1100841009524 zinc-ribbon domain; Region: zinc_ribbon_5; cl11777 1100841009525 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1100841009526 catalytic residues [active] 1100841009527 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 1100841009528 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1100841009529 Putative phosphatase (DUF442); Region: DUF442; cl17385 1100841009530 dihydrolipoamide dehydrogenase; Validated; Region: PRK06292 1100841009531 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1100841009532 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1100841009533 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1100841009534 Domain of unknown function (DUF4154); Region: DUF4154; pfam13689 1100841009535 putative inner membrane diguanylate cyclase; Provisional; Region: PRK09966 1100841009536 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1100841009537 metal binding site [ion binding]; metal-binding site 1100841009538 active site 1100841009539 I-site; other site 1100841009540 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 1100841009541 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1100841009542 ligand binding site [chemical binding]; other site 1100841009543 phosphodiesterase YaeI; Provisional; Region: PRK11340 1100841009544 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 1100841009545 putative active site [active] 1100841009546 putative metal binding site [ion binding]; other site 1100841009547 Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502 1100841009548 Putative catalytic domain, repeat 1, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_1; cd09111 1100841009549 putative active site [active] 1100841009550 catalytic site [active] 1100841009551 Putative catalytic domain, repeat 2, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_2; cd09113 1100841009552 putative active site [active] 1100841009553 catalytic site [active] 1100841009554 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1100841009555 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1100841009556 putative acyl-acceptor binding pocket; other site 1100841009557 HflX GTPase family; Region: HflX; cd01878 1100841009558 G1 box; other site 1100841009559 GTP/Mg2+ binding site [chemical binding]; other site 1100841009560 Switch I region; other site 1100841009561 G2 box; other site 1100841009562 G3 box; other site 1100841009563 Switch II region; other site 1100841009564 G4 box; other site 1100841009565 G5 box; other site 1100841009566 LrgB-like family; Region: LrgB; cl00596 1100841009567 Uncharacterized protein conserved in bacteria (DUF2147); Region: DUF2147; pfam09917 1100841009568 diadenosine tetraphosphatase; Reviewed; Region: apaH; PRK00166 1100841009569 Escherichia coli ApaH and related proteins, metallophosphatase domain; Region: MPP_ApaH; cd07422 1100841009570 active site 1100841009571 metal binding site [ion binding]; metal-binding site 1100841009572 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 1100841009573 Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030 1100841009574 4-hydroxythreonine-4-phosphate dehydrogenase; Region: pdxA; TIGR00557 1100841009575 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 1100841009576 23S rRNA interface [nucleotide binding]; other site 1100841009577 L3 interface [polypeptide binding]; other site 1100841009578 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 1100841009579 stringent starvation protein A; Provisional; Region: sspA; PRK09481 1100841009580 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1100841009581 C-terminal, alpha helical domain of Stringent starvation protein A; Region: GST_C_SspA; cd03186 1100841009582 dimer interface [polypeptide binding]; other site 1100841009583 N-terminal domain interface [polypeptide binding]; other site 1100841009584 ClpXP protease specificity-enhancing factor; Provisional; Region: PRK11798 1100841009585 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 1100841009586 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1100841009587 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1100841009588 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785 1100841009589 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1100841009590 carboxyltransferase (CT) interaction site; other site 1100841009591 biotinylation site [posttranslational modification]; other site 1100841009592 enoyl-CoA hydratase; Provisional; Region: PRK05995 1100841009593 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1100841009594 substrate binding site [chemical binding]; other site 1100841009595 oxyanion hole (OAH) forming residues; other site 1100841009596 trimer interface [polypeptide binding]; other site 1100841009597 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1100841009598 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1100841009599 active site 1100841009600 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 1100841009601 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 1100841009602 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 1100841009603 Trans-2-enoyl-CoA reductase (TER) and 2,4-dienoyl-CoA reductase (DECR), atypical (a) SDR; Region: TER_DECR_SDR_a; cd05369 1100841009604 NAD(P) binding site [chemical binding]; other site 1100841009605 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1100841009606 substrate binding site [chemical binding]; other site 1100841009607 homotetramer interface [polypeptide binding]; other site 1100841009608 active site 1100841009609 homodimer interface [polypeptide binding]; other site 1100841009610 Protein of unknown function (DUF1446); Region: DUF1446; pfam07287 1100841009611 RUN domain; Region: RUN; cl02689 1100841009612 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1100841009613 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1100841009614 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1100841009615 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1100841009616 active site 1100841009617 Protein of unknown function (DUF4256); Region: DUF4256; pfam14066 1100841009618 Domain of unknown function (DUF2007); Region: DUF2007; pfam09413 1100841009619 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 1100841009620 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 1100841009621 Protein involved in catabolism of external DNA [General function prediction only]; Region: ComJ; COG2961 1100841009622 Predicted proline hydroxylase [Posttranslational modification, protein turnover, chaperones]; Region: EGL-9; COG3751 1100841009623 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; pfam13640 1100841009624 Protein of unknown function (DUF2789); Region: DUF2789; pfam10982 1100841009625 malate dehydrogenase; Provisional; Region: PRK05442 1100841009626 Chloroplast-like malate dehydrogenases; Region: MDH_choloroplast_like; cd01338 1100841009627 NAD(P) binding site [chemical binding]; other site 1100841009628 dimer interface [polypeptide binding]; other site 1100841009629 malate binding site [chemical binding]; other site 1100841009630 Ribonuclease T2 (RNase T2) is a widespread family of secreted RNases found in every organism examined thus far. This family includes RNase Rh, RNase MC1, RNase LE, and self-incompatibility RNases (S-RNases). Plant T2 RNases are expressed during leaf...; Region: RNase_T2_prok; cd01062 1100841009631 B1 nucleotide binding pocket [chemical binding]; other site 1100841009632 B2 nucleotide binding pocket [chemical binding]; other site 1100841009633 CAS motifs; other site 1100841009634 active site 1100841009635 lytic murein transglycosylase; Provisional; Region: PRK11619 1100841009636 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1100841009637 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1100841009638 catalytic residue [active] 1100841009639 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325 1100841009640 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 1100841009641 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1100841009642 FeS/SAM binding site; other site 1100841009643 TRAM domain; Region: TRAM; cl01282 1100841009644 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 1100841009645 PhoH-like protein; Region: PhoH; pfam02562 1100841009646 metal-binding heat shock protein; Provisional; Region: PRK00016 1100841009647 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 1100841009648 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 1100841009649 Protein of unknown function (DUF3108); Region: DUF3108; pfam11306 1100841009650 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1100841009651 active site 1100841009652 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 1100841009653 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1100841009654 Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918 1100841009655 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1100841009656 EamA-like transporter family; Region: EamA; pfam00892 1100841009657 Helix-turn-helix domain; Region: HTH_18; pfam12833 1100841009658 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1100841009659 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 1100841009660 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 1100841009661 YcxB-like protein; Region: YcxB; pfam14317 1100841009662 Nitroreductase-like family 4. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_4; cd02140 1100841009663 dimer interface [polypeptide binding]; other site 1100841009664 FMN binding site [chemical binding]; other site 1100841009665 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1100841009666 ribonuclease R; Region: RNase_R; TIGR02063 1100841009667 RNB domain; Region: RNB; pfam00773 1100841009668 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 1100841009669 RNA binding site [nucleotide binding]; other site 1100841009670 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 1100841009671 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 1100841009672 active site 1100841009673 Zn binding site [ion binding]; other site 1100841009674 Probable metal-binding protein (DUF2387); Region: DUF2387; pfam09526 1100841009675 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274 1100841009676 rhomboid family GlyGly-CTERM serine protease; Region: rhom_GG_sort; TIGR03902 1100841009677 Flavinator of succinate dehydrogenase; Region: Sdh5; pfam03937 1100841009678 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1100841009679 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1100841009680 active site 1100841009681 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1100841009682 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1100841009683 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 1100841009684 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 1100841009685 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 1100841009686 alphaNTD homodimer interface [polypeptide binding]; other site 1100841009687 alphaNTD - beta interaction site [polypeptide binding]; other site 1100841009688 alphaNTD - beta' interaction site [polypeptide binding]; other site 1100841009689 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 1100841009690 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 1100841009691 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 1100841009692 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1100841009693 RNA binding surface [nucleotide binding]; other site 1100841009694 30S ribosomal protein S11; Validated; Region: PRK05309 1100841009695 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 1100841009696 30S ribosomal protein S13; Region: bact_S13; TIGR03631 1100841009697 Ribosomal protein L36; Region: Ribosomal_L36; pfam00444 1100841009698 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 1100841009699 SecY translocase; Region: SecY; pfam00344 1100841009700 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 1100841009701 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 1100841009702 23S rRNA binding site [nucleotide binding]; other site 1100841009703 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 1100841009704 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 1100841009705 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 1100841009706 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 1100841009707 5S rRNA interface [nucleotide binding]; other site 1100841009708 23S rRNA interface [nucleotide binding]; other site 1100841009709 L5 interface [polypeptide binding]; other site 1100841009710 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 1100841009711 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1100841009712 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1100841009713 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 1100841009714 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 1100841009715 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 1100841009716 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 1100841009717 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 1100841009718 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 1100841009719 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 1100841009720 RNA binding site [nucleotide binding]; other site 1100841009721 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 1100841009722 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 1100841009723 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 1100841009724 23S rRNA interface [nucleotide binding]; other site 1100841009725 putative translocon interaction site; other site 1100841009726 signal recognition particle (SRP54) interaction site; other site 1100841009727 L23 interface [polypeptide binding]; other site 1100841009728 trigger factor interaction site; other site 1100841009729 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 1100841009730 23S rRNA interface [nucleotide binding]; other site 1100841009731 5S rRNA interface [nucleotide binding]; other site 1100841009732 putative antibiotic binding site [chemical binding]; other site 1100841009733 L25 interface [polypeptide binding]; other site 1100841009734 L27 interface [polypeptide binding]; other site 1100841009735 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 1100841009736 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 1100841009737 G-X-X-G motif; other site 1100841009738 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 1100841009739 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 1100841009740 putative translocon binding site; other site 1100841009741 protein-rRNA interface [nucleotide binding]; other site 1100841009742 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 1100841009743 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 1100841009744 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 1100841009745 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 1100841009746 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 1100841009747 Ribosomal protein L4/L1 family; Region: Ribosomal_L4; cl00325 1100841009748 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 1100841009749 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 1100841009750 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 1100841009751 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 1100841009752 catalytic triad [active] 1100841009753 cystathionine beta-lyase; Provisional; Region: PRK07050 1100841009754 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1100841009755 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1100841009756 catalytic residue [active] 1100841009757 Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872 1100841009758 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1100841009759 Walker A motif; other site 1100841009760 ATP binding site [chemical binding]; other site 1100841009761 Walker B motif; other site 1100841009762 Zonular occludens toxin (Zot); Region: Zot; cl17485 1100841009763 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 1100841009764 heme-binding site [chemical binding]; other site 1100841009765 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 1100841009766 FAD binding pocket [chemical binding]; other site 1100841009767 conserved FAD binding motif [chemical binding]; other site 1100841009768 phosphate binding motif [ion binding]; other site 1100841009769 Transcriptional regulator; Region: Rrf2; cl17282 1100841009770 Rrf2 family protein; Region: rrf2_super; TIGR00738 1100841009771 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 1100841009772 G1 box; other site 1100841009773 GTP/Mg2+ binding site [chemical binding]; other site 1100841009774 Switch I region; other site 1100841009775 G2 box; other site 1100841009776 G3 box; other site 1100841009777 Switch II region; other site 1100841009778 G4 box; other site 1100841009779 G5 box; other site 1100841009780 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687 1100841009781 Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118 1100841009782 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1100841009783 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 1100841009784 Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946 1100841009785 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 1100841009786 active site 1100841009787 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 1100841009788 catalytic triad [active] 1100841009789 dimer interface [polypeptide binding]; other site 1100841009790 glycerol-3-phosphate O-acyltransferase; Region: plsB; TIGR03703 1100841009791 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Region: LPLAT_DHAPAT-like; cd07993 1100841009792 putative acyl-acceptor binding pocket; other site 1100841009793 lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096 1100841009794 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1100841009795 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1100841009796 NAD(P) binding site [chemical binding]; other site 1100841009797 active site 1100841009798 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 1100841009799 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 1100841009800 ssDNA binding site; other site 1100841009801 generic binding surface II; other site 1100841009802 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1100841009803 ATP binding site [chemical binding]; other site 1100841009804 putative Mg++ binding site [ion binding]; other site 1100841009805 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1100841009806 nucleotide binding region [chemical binding]; other site 1100841009807 ATP-binding site [chemical binding]; other site 1100841009808 comF family protein; Region: comF; TIGR00201 1100841009809 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1100841009810 active site 1100841009811 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_31; cd04690 1100841009812 nudix motif; other site 1100841009813 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 1100841009814 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 1100841009815 Escherichia coli Mg2+ transporter CorA_like subgroup; Region: EcCorA-like_1; cd12835 1100841009816 Cl binding site [ion binding]; other site 1100841009817 oligomer interface [polypeptide binding]; other site 1100841009818 Toluene tolerance, Ttg2; Region: Tol_Tol_Ttg2; pfam05494 1100841009819 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 1100841009820 mce related protein; Region: MCE; pfam02470 1100841009821 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 1100841009822 Permease; Region: Permease; cl00510 1100841009823 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 1100841009824 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 1100841009825 Walker A/P-loop; other site 1100841009826 ATP binding site [chemical binding]; other site 1100841009827 Q-loop/lid; other site 1100841009828 ABC transporter signature motif; other site 1100841009829 Walker B; other site 1100841009830 D-loop; other site 1100841009831 H-loop/switch region; other site 1100841009832 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1100841009833 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1100841009834 ATP binding site [chemical binding]; other site 1100841009835 Mg++ binding site [ion binding]; other site 1100841009836 motif III; other site 1100841009837 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1100841009838 nucleotide binding region [chemical binding]; other site 1100841009839 ATP-binding site [chemical binding]; other site 1100841009840 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1100841009841 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 1100841009842 active site 1100841009843 dimerization interface [polypeptide binding]; other site 1100841009844 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 1100841009845 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 1100841009846 TPP-binding site; other site 1100841009847 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1100841009848 PYR/PP interface [polypeptide binding]; other site 1100841009849 dimer interface [polypeptide binding]; other site 1100841009850 TPP binding site [chemical binding]; other site 1100841009851 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1100841009852 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cl00522 1100841009853 coproporphyrinogen III oxidase; Provisional; Region: PRK05330 1100841009854 Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; pfam01218 1100841009855 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 1100841009856 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 1100841009857 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 1100841009858 shikimate binding site; other site 1100841009859 NAD(P) binding site [chemical binding]; other site 1100841009860 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 1100841009861 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 1100841009862 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1100841009863 active site 1100841009864 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 1100841009865 hypothetical protein; Provisional; Region: PRK11615 1100841009866 PspC domain; Region: PspC; pfam04024 1100841009867 HPP family; Region: HPP; pfam04982 1100841009868 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 1100841009869 FOG: CBS domain [General function prediction only]; Region: COG0517 1100841009870 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the HPP motif domain. These proteins are integral membrane proteins with four transmembrane spanning helices. The function of these proteins is...; Region: CBS_pair_HPP_assoc; cd04600 1100841009871 probable DNA metabolism protein; Region: SAM_7_link_chp; TIGR03915 1100841009872 putative DNA modification/repair radical SAM protein; Region: rSAM_link_UDG; TIGR03916 1100841009873 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1100841009874 FeS/SAM binding site; other site 1100841009875 Protein of unknown function (DUF1311); Region: DUF1311; pfam07007 1100841009876 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 1100841009877 dimer interface [polypeptide binding]; other site 1100841009878 motif 1; other site 1100841009879 active site 1100841009880 motif 2; other site 1100841009881 motif 3; other site 1100841009882 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 1100841009883 YCII-related domain; Region: YCII; cl00999 1100841009884 EamA-like transporter family; Region: EamA; pfam00892 1100841009885 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 1100841009886 EamA-like transporter family; Region: EamA; pfam00892 1100841009887 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1100841009888 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1100841009889 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1100841009890 dimerization interface [polypeptide binding]; other site 1100841009891 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 1100841009892 active site 1100841009893 catalytic residues [active] 1100841009894 Peptidase M14 Succinylglutamate desuccinylase (ASTE) subfamily; Region: M14_ASTE; cd03855 1100841009895 Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952 1100841009896 putative active site [active] 1100841009897 Zn binding site [ion binding]; other site 1100841009898 succinylarginine dihydrolase; Provisional; Region: PRK13281 1100841009899 succinylglutamic semialdehyde dehydrogenase; Reviewed; Region: astD; PRK09457 1100841009900 N-succinylglutamate 5-semialdehyde dehydrogenase, AstD-like; Region: ALDH_SGSD_AstD; cd07095 1100841009901 NAD(P) binding site [chemical binding]; other site 1100841009902 catalytic residues [active] 1100841009903 Arginine/ornithine N-succinyltransferase beta subunit [Amino acid transport and metabolism]; Region: AstA; COG3138 1100841009904 Arginine N-succinyltransferase beta subunit; Region: AstA; cl11440 1100841009905 bifunctional succinylornithine transaminase/acetylornithine transaminase; Provisional; Region: PRK12381 1100841009906 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1100841009907 inhibitor-cofactor binding pocket; inhibition site 1100841009908 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1100841009909 catalytic residue [active] 1100841009910 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 1100841009911 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 1100841009912 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 1100841009913 NAD(P) binding site [chemical binding]; other site 1100841009914 S-methylmethionine transporter; Provisional; Region: PRK11387 1100841009915 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1100841009916 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1100841009917 S-adenosylmethionine binding site [chemical binding]; other site 1100841009918 Endonuclease related to archaeal Holliday junction resolvase; Region: Endonuc_Holl; cl01958 1100841009919 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1100841009920 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1100841009921 Magnesium ion binding site [ion binding]; other site 1100841009922 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1100841009923 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1100841009924 Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032 1100841009925 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 1100841009926 E-class dimer interface [polypeptide binding]; other site 1100841009927 P-class dimer interface [polypeptide binding]; other site 1100841009928 active site 1100841009929 Cu2+ binding site [ion binding]; other site 1100841009930 Zn2+ binding site [ion binding]; other site 1100841009931 FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805 1100841009932 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 1100841009933 multidrug efflux system translocase MdfA; Provisional; Region: PRK15402 1100841009934 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1100841009935 putative substrate translocation pore; other site 1100841009936 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 1100841009937 Uncharacterized conserved protein [Function unknown]; Region: COG1359 1100841009938 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1100841009939 FAD binding domain; Region: FAD_binding_4; pfam01565 1100841009940 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790 1100841009941 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_3; cd12176 1100841009942 ligand binding site [chemical binding]; other site 1100841009943 NAD binding site [chemical binding]; other site 1100841009944 tetramer interface [polypeptide binding]; other site 1100841009945 catalytic site [active] 1100841009946 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 1100841009947 L-serine binding site [chemical binding]; other site 1100841009948 ACT domain interface; other site 1100841009949 threonine and homoserine efflux system; Provisional; Region: PRK10532 1100841009950 EamA-like transporter family; Region: EamA; pfam00892 1100841009951 Threonine/homoserine efflux transporter [Amino acid transport and metabolism]; Region: rhtA; COG5006 1100841009952 Hemerythrin-like domain; Region: Hr-like; cd12108 1100841009953 hypothetical protein; Provisional; Region: PRK10621 1100841009954 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1100841009955 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05033 1100841009956 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 1100841009957 RNA binding site [nucleotide binding]; other site 1100841009958 active site 1100841009959 Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157 1100841009960 lipase chaperone; Provisional; Region: PRK01294 1100841009961 Proteobacterial lipase chaperone protein; Region: Lipase_chap; pfam03280 1100841009962 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 1100841009963 Putative serine esterase (DUF676); Region: DUF676; pfam05057 1100841009964 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 1100841009965 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 1100841009966 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 1100841009967 RimM N-terminal domain; Region: RimM; pfam01782 1100841009968 PRC-barrel domain; Region: PRC; pfam05239 1100841009969 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 1100841009970 Tfp pilus assembly protein PilE [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilE; COG4968 1100841009971 Tfp pilus assembly protein PilE [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilE; COG4968 1100841009972 von Willebrand factor type A domain; Region: VWA_2; pfam13519 1100841009973 Neisseria PilC beta-propeller domain; Region: Neisseria_PilC; pfam05567 1100841009974 type IV pilus modification protein PilV; Region: type_IV_pilV; TIGR02523 1100841009975 Tfp pilus assembly protein FimT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimT; COG4970 1100841009976 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 1100841009977 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 1100841009978 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 1100841009979 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 1100841009980 catalytic site [active] 1100841009981 G-X2-G-X-G-K; other site 1100841009982 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 1100841009983 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 1100841009984 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1100841009985 Zn2+ binding site [ion binding]; other site 1100841009986 Mg2+ binding site [ion binding]; other site 1100841009987 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1100841009988 synthetase active site [active] 1100841009989 NTP binding site [chemical binding]; other site 1100841009990 metal binding site [ion binding]; metal-binding site 1100841009991 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 1100841009992 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1100841009993 ACT domain; Region: ACT_4; pfam13291 1100841009994 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 1100841009995 homotrimer interaction site [polypeptide binding]; other site 1100841009996 putative active site [active] 1100841009997 Bacterioferritin-associated ferredoxin [Inorganic ion transport and metabolism]; Region: Bfd; COG2906 1100841009998 Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193 1100841009999 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 1100841010000 heme binding site [chemical binding]; other site 1100841010001 ferroxidase pore; other site 1100841010002 ferroxidase diiron center [ion binding]; other site 1100841010003 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 1100841010004 O-Antigen ligase; Region: Wzy_C; pfam04932 1100841010005 Domain of unknown function (DUF3366); Region: DUF3366; pfam11846 1100841010006 O-antigen ligase like membrane protein; Region: O-antigen_lig; pfam13425 1100841010007 Tfp pilus assembly protein, major pilin PilA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilA; COG4969 1100841010008 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 1100841010009 Pilin (bacterial filament); Region: Pilin; pfam00114 1100841010010 Repair protein; Region: Repair_PSII; pfam04536 1100841010011 Repair protein; Region: Repair_PSII; pfam04536 1100841010012 LemA family; Region: LemA; pfam04011 1100841010013 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687 1100841010014 Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118 1100841010015 glutamate synthase small subunit family protein, proteobacterial; Region: gltD_gamma_fam; TIGR01318 1100841010016 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1100841010017 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1100841010018 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 1100841010019 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 1100841010020 active site 1100841010021 dimer interface [polypeptide binding]; other site 1100841010022 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 1100841010023 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 1100841010024 active site 1100841010025 FMN binding site [chemical binding]; other site 1100841010026 substrate binding site [chemical binding]; other site 1100841010027 3Fe-4S cluster binding site [ion binding]; other site 1100841010028 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 1100841010029 domain interface; other site 1100841010030 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 1100841010031 active site 1100841010032 dimer interface [polypeptide binding]; other site 1100841010033 metal binding site [ion binding]; metal-binding site 1100841010034 shikimate kinase; Reviewed; Region: aroK; PRK00131 1100841010035 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 1100841010036 ADP binding site [chemical binding]; other site 1100841010037 magnesium binding site [ion binding]; other site 1100841010038 putative shikimate binding site; other site 1100841010039 AMIN domain; Region: AMIN; pfam11741 1100841010040 type IV pilus secretin (or competence protein) PilQ; Region: IV_pilus_PilQ; TIGR02515 1100841010041 Secretin and TonB N terminus short domain; Region: STN; smart00965 1100841010042 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 1100841010043 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 1100841010044 Tfp pilus assembly protein PilP [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilP; COG3168 1100841010045 Pilus assembly protein, PilP; Region: PilP; pfam04351 1100841010046 Pilus assembly protein, PilO; Region: PilO; pfam04350 1100841010047 Tfp pilus assembly protein PilN [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilN; COG3166 1100841010048 Fimbrial assembly protein (PilN); Region: PilN; pfam05137 1100841010049 Competence protein A; Region: Competence_A; pfam11104 1100841010050 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1100841010051 Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane]; Region: MrcA; COG5009 1100841010052 Transglycosylase; Region: Transgly; pfam00912 1100841010053 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 1100841010054 23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088 1100841010055 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1100841010056 S-adenosylmethionine binding site [chemical binding]; other site 1100841010057 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 1100841010058 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 1100841010059 Mg++ binding site [ion binding]; other site 1100841010060 putative catalytic motif [active] 1100841010061 putative substrate binding site [chemical binding]; other site 1100841010062 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1100841010063 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Region: murF; TIGR01143 1100841010064 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1100841010065 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1100841010066 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 1100841010067 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1100841010068 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1100841010069 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 1100841010070 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1100841010071 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1100841010072 Cell division protein FtsL; Region: FtsL; pfam04999 1100841010073 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 1100841010074 MraW methylase family; Region: Methyltransf_5; cl17771 1100841010075 ABC-type sulfate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: Sbp; COG1613 1100841010076 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 1100841010077 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 1100841010078 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 1100841010079 active site 1100841010080 HIGH motif; other site 1100841010081 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 1100841010082 active site 1100841010083 KMSKS motif; other site 1100841010084 S-methylmethionine transporter; Provisional; Region: PRK11387 1100841010085 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 1100841010086 heavy metal efflux pump, CzcA family; Region: 2A0601; TIGR00914 1100841010087 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1100841010088 Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999 1100841010089 HlyD family secretion protein; Region: HlyD_3; pfam13437 1100841010090 Outer membrane efflux protein; Region: OEP; pfam02321 1100841010091 Outer membrane efflux protein; Region: OEP; pfam02321 1100841010092 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 1100841010093 hypothetical protein; Provisional; Region: PRK10215 1100841010094 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 1100841010095 Sel1-like repeats; Region: SEL1; smart00671 1100841010096 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 1100841010097 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1100841010098 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1100841010099 ABC transporter; Region: ABC_tran_2; pfam12848 1100841010100 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1100841010101 O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK06084 1100841010102 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1100841010103 homodimer interface [polypeptide binding]; other site 1100841010104 substrate-cofactor binding pocket; other site 1100841010105 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1100841010106 catalytic residue [active] 1100841010107 classical (c) SDRs; Region: SDR_c; cd05233 1100841010108 NAD(P) binding site [chemical binding]; other site 1100841010109 active site 1100841010110 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 1100841010111 Sulfate transporter family; Region: Sulfate_transp; pfam00916 1100841010112 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378 1100841010113 active site clefts [active] 1100841010114 zinc binding site [ion binding]; other site 1100841010115 dimer interface [polypeptide binding]; other site 1100841010116 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 1100841010117 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 1100841010118 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 1100841010119 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 1100841010120 RNA binding site [nucleotide binding]; other site 1100841010121 hypothetical protein; Provisional; Region: PRK10215 1100841010122 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 1100841010123 Sel1-like repeats; Region: SEL1; smart00671 1100841010124 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 1100841010125 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1100841010126 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1100841010127 ABC transporter; Region: ABC_tran_2; pfam12848 1100841010128 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1100841010129 O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK06084 1100841010130 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1100841010131 homodimer interface [polypeptide binding]; other site 1100841010132 substrate-cofactor binding pocket; other site 1100841010133 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1100841010134 catalytic residue [active] 1100841010135 classical (c) SDRs; Region: SDR_c; cd05233 1100841010136 NAD(P) binding site [chemical binding]; other site 1100841010137 active site 1100841010138 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 1100841010139 Sulfate transporter family; Region: Sulfate_transp; pfam00916 1100841010140 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378 1100841010141 active site clefts [active] 1100841010142 zinc binding site [ion binding]; other site 1100841010143 dimer interface [polypeptide binding]; other site 1100841010144 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 1100841010145 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 1100841010146 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 1100841010147 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 1100841010148 RNA binding site [nucleotide binding]; other site 1100841010149 osmolarity response regulator; Provisional; Region: ompR; PRK09468 1100841010150 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1100841010151 active site 1100841010152 phosphorylation site [posttranslational modification] 1100841010153 intermolecular recognition site; other site 1100841010154 dimerization interface [polypeptide binding]; other site 1100841010155 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1100841010156 DNA binding site [nucleotide binding] 1100841010157 osmolarity sensor protein; Provisional; Region: envZ; PRK09467 1100841010158 HAMP domain; Region: HAMP; pfam00672 1100841010159 dimerization interface [polypeptide binding]; other site 1100841010160 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1100841010161 dimer interface [polypeptide binding]; other site 1100841010162 phosphorylation site [posttranslational modification] 1100841010163 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1100841010164 ATP binding site [chemical binding]; other site 1100841010165 Mg2+ binding site [ion binding]; other site 1100841010166 G-X-G motif; other site 1100841010167 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 1100841010168 succinate CoA transferase; Region: YgfH_subfam; TIGR03458 1100841010169 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 1100841010170 putative acetyltransferase; Provisional; Region: PRK03624 1100841010171 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1100841010172 Coenzyme A binding pocket [chemical binding]; other site 1100841010173 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1100841010174 Coenzyme A binding pocket [chemical binding]; other site 1100841010175 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 1100841010176 putative active site pocket [active] 1100841010177 4-fold oligomerization interface [polypeptide binding]; other site 1100841010178 metal binding residues [ion binding]; metal-binding site 1100841010179 3-fold/trimer interface [polypeptide binding]; other site 1100841010180 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141 1100841010181 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 1100841010182 putative active site [active] 1100841010183 oxyanion strand; other site 1100841010184 catalytic triad [active] 1100841010185 Protein of unknown function (DUF805); Region: DUF805; pfam05656 1100841010186 DEDDy 3'-5' exonuclease domain of WRN and similar proteins; Region: WRN_exo; cd06141 1100841010187 catalytic site [active] 1100841010188 putative active site [active] 1100841010189 putative substrate binding site [chemical binding]; other site 1100841010190 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 1100841010191 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 1100841010192 catalytic residues [active] 1100841010193 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1100841010194 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1100841010195 non-specific DNA binding site [nucleotide binding]; other site 1100841010196 salt bridge; other site 1100841010197 sequence-specific DNA binding site [nucleotide binding]; other site 1100841010198 EamA-like transporter family; Region: EamA; pfam00892 1100841010199 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 1100841010200 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 1100841010201 Predicted membrane protein [Function unknown]; Region: COG3671 1100841010202 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1100841010203 DNA-binding site [nucleotide binding]; DNA binding site 1100841010204 RNA-binding motif; other site 1100841010205 Protein of unknown function (DUF1294); Region: DUF1294; pfam06961 1100841010206 Homoserine Kinase, type II. Homoserine kinase is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and...; Region: HomoserineK_II; cd05153 1100841010207 Phosphotransferase enzyme family; Region: APH; pfam01636 1100841010208 putative active site [active] 1100841010209 putative substrate binding site [chemical binding]; other site 1100841010210 ATP binding site [chemical binding]; other site 1100841010211 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 1100841010212 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 1100841010213 substrate binding site [chemical binding]; other site 1100841010214 glutamase interaction surface [polypeptide binding]; other site 1100841010215 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 1100841010216 Helix-turn-helix domain; Region: HTH_18; pfam12833 1100841010217 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1100841010218 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 1100841010219 amphipathic channel; other site 1100841010220 Asn-Pro-Ala signature motifs; other site 1100841010221 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 1100841010222 DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases. They exists as monomers and homodimers; Region: NUC; cd00091 1100841010223 DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892 1100841010224 active site 1100841010225 substrate binding site [chemical binding]; other site 1100841010226 Mg2+ binding site [ion binding]; other site 1100841010227 K+ transporter [Inorganic ion transport and metabolism]; Region: Kup; COG3158 1100841010228 potassium uptake protein; Region: kup; TIGR00794 1100841010229 Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525 1100841010230 Predicted transcriptional regulators [Transcription]; Region: COG1733 1100841010231 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1100841010232 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 1100841010233 Sel1-like repeats; Region: SEL1; smart00671 1100841010234 Sel1 repeat; Region: Sel1; cl02723 1100841010235 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1100841010236 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1100841010237 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1100841010238 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1100841010239 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1100841010240 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1100841010241 active site 1100841010242 catalytic tetrad [active]