-- dump date   	20140618_190850
-- class       	Genbank::misc_feature
-- table       	misc_feature_note
-- id	note
1400867000001	DnaA N-terminal domain; Region: DnaA_N; pfam11638
1400867000002	chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362
1400867000003	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1400867000004	Walker A motif; other site
1400867000005	ATP binding site [chemical binding]; other site
1400867000006	Walker B motif; other site
1400867000007	arginine finger; other site
1400867000008	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
1400867000009	DnaA box-binding interface [nucleotide binding]; other site
1400867000010	DNA polymerase III subunit beta; Validated; Region: PRK05643
1400867000011	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
1400867000012	putative DNA binding surface [nucleotide binding]; other site
1400867000013	dimer interface [polypeptide binding]; other site
1400867000014	beta-clamp/clamp loader binding surface; other site
1400867000015	beta-clamp/translesion DNA polymerase binding surface; other site
1400867000016	recombination protein F; Reviewed; Region: recF; PRK00064
1400867000017	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1400867000018	Walker A/P-loop; other site
1400867000019	ATP binding site [chemical binding]; other site
1400867000020	Q-loop/lid; other site
1400867000021	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1400867000022	ABC transporter signature motif; other site
1400867000023	Walker B; other site
1400867000024	D-loop; other site
1400867000025	H-loop/switch region; other site
1400867000026	DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939
1400867000027	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1400867000028	ATP binding site [chemical binding]; other site
1400867000029	Mg2+ binding site [ion binding]; other site
1400867000030	G-X-G motif; other site
1400867000031	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
1400867000032	anchoring element; other site
1400867000033	dimer interface [polypeptide binding]; other site
1400867000034	ATP binding site [chemical binding]; other site
1400867000035	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
1400867000036	active site
1400867000037	putative metal-binding site [ion binding]; other site
1400867000038	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
1400867000039	Cytochrome b562; Region: Cytochrom_B562; pfam07361
1400867000040	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
1400867000041	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
1400867000042	putative ABC transporter ATP-binding protein; Provisional; Region: PRK10636
1400867000043	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1400867000044	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1400867000045	ABC transporter; Region: ABC_tran_2; pfam12848
1400867000046	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1400867000047	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
1400867000048	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
1400867000049	iron-sulfur cluster insertion protein ErpA; Provisional; Region: PRK13623
1400867000050	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
1400867000051	anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585
1400867000052	tyrosyl-tRNA synthetase; Validated; Region: PRK05912
1400867000053	catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805
1400867000054	active site
1400867000055	HIGH motif; other site
1400867000056	dimer interface [polypeptide binding]; other site
1400867000057	KMSKS motif; other site
1400867000058	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
1400867000059	GST_N family, unknown subfamily 4; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_4; cd03056
1400867000060	putative C-terminal domain interface [polypeptide binding]; other site
1400867000061	putative GSH binding site (G-site) [chemical binding]; other site
1400867000062	putative dimer interface [polypeptide binding]; other site
1400867000063	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776
1400867000064	dimer interface [polypeptide binding]; other site
1400867000065	N-terminal domain interface [polypeptide binding]; other site
1400867000066	substrate binding pocket (H-site) [chemical binding]; other site
1400867000067	outer membrane protein; Region: OMP_w_GlyGly; TIGR04219
1400867000068	uncharacterized bacterial and archaeal solute carrier 6 subfamily; solute-binding domain; Region: SLC6sbd_u1; cd10334
1400867000069	Na2 binding site [ion binding]; other site
1400867000070	putative substrate binding site 1 [chemical binding]; other site
1400867000071	Na binding site 1 [ion binding]; other site
1400867000072	putative substrate binding site 2 [chemical binding]; other site
1400867000073	16S rRNA methyltransferase B; Provisional; Region: PRK10901
1400867000074	NusB family; Region: NusB; pfam01029
1400867000075	putative RNA binding site [nucleotide binding]; other site
1400867000076	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1400867000077	S-adenosylmethionine binding site [chemical binding]; other site
1400867000078	methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005
1400867000079	Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646
1400867000080	putative active site [active]
1400867000081	substrate binding site [chemical binding]; other site
1400867000082	putative cosubstrate binding site; other site
1400867000083	catalytic site [active]
1400867000084	C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704
1400867000085	substrate binding site [chemical binding]; other site
1400867000086	dihydroxy-acid dehydratase; Provisional; Region: PRK12448
1400867000087	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
1400867000088	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1400867000089	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1400867000090	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1400867000091	dimerization interface [polypeptide binding]; other site
1400867000092	pyrimidine utilization transport protein G; Region: RutG; TIGR03616
1400867000093	phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009
1400867000094	Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352
1400867000095	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1400867000096	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1400867000097	AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246
1400867000098	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
1400867000099	HlyD family secretion protein; Region: HlyD_3; pfam13437
1400867000100	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
1400867000101	Inorganic H+ pyrophosphatase; Region: H_PPase; pfam03030
1400867000102	chaperone protein DnaJ; Provisional; Region: PRK10767
1400867000103	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
1400867000104	HSP70 interaction site [polypeptide binding]; other site
1400867000105	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262
1400867000106	substrate binding site [polypeptide binding]; other site
1400867000107	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
1400867000108	Zn binding sites [ion binding]; other site
1400867000109	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
1400867000110	dimer interface [polypeptide binding]; other site
1400867000111	dihydrodipicolinate reductase; Provisional; Region: PRK00048
1400867000112	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
1400867000113	Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173
1400867000114	Uncharacterized subgroup of the steroidogenic acute regulatory protein (StAR)-related lipid transfer (START) domain family; Region: START_1; cd08876
1400867000115	putative lipid binding site [chemical binding]; other site
1400867000116	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
1400867000117	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1400867000118	putative substrate translocation pore; other site
1400867000119	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1400867000120	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
1400867000121	active site
1400867000122	catalytic tetrad [active]
1400867000123	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1400867000124	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1400867000125	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA; cd08478
1400867000126	putative effector binding pocket; other site
1400867000127	dimerization interface [polypeptide binding]; other site
1400867000128	membrane-bound lytic murein transglycosylase D; Provisional; Region: mltD; PRK10783
1400867000129	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
1400867000130	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1400867000131	DNA-binding site [nucleotide binding]; DNA binding site
1400867000132	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1400867000133	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1400867000134	homodimer interface [polypeptide binding]; other site
1400867000135	catalytic residue [active]
1400867000136	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
1400867000137	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283
1400867000138	putative NAD(P) binding site [chemical binding]; other site
1400867000139	putative substrate binding site [chemical binding]; other site
1400867000140	catalytic Zn binding site [ion binding]; other site
1400867000141	structural Zn binding site [ion binding]; other site
1400867000142	dimer interface [polypeptide binding]; other site
1400867000143	Methyladenine glycosylase; Region: Adenine_glyco; pfam03352
1400867000144	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
1400867000145	Peptidase family M23; Region: Peptidase_M23; pfam01551
1400867000146	A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194
1400867000147	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
1400867000148	minor groove reading motif; other site
1400867000149	helix-hairpin-helix signature motif; other site
1400867000150	substrate binding pocket [chemical binding]; other site
1400867000151	active site
1400867000152	iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525
1400867000153	DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread  A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431
1400867000154	DNA binding and oxoG recognition site [nucleotide binding]
1400867000155	Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537
1400867000156	nucleotide binding site/active site [active]
1400867000157	HIT family signature motif; other site
1400867000158	catalytic residue [active]
1400867000159	Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412
1400867000160	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
1400867000161	Small integral membrane protein [Function unknown]; Region: COG5487; cl17674
1400867000162	hypothetical protein; Provisional; Region: PRK05170
1400867000163	dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606
1400867000164	Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995
1400867000165	recombination factor protein RarA; Reviewed; Region: PRK13342
1400867000166	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1400867000167	Walker A motif; other site
1400867000168	ATP binding site [chemical binding]; other site
1400867000169	Walker B motif; other site
1400867000170	arginine finger; other site
1400867000171	MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002
1400867000172	Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226
1400867000173	phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362
1400867000174	bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415
1400867000175	ATP binding site [chemical binding]; other site
1400867000176	active site
1400867000177	substrate binding site [chemical binding]; other site
1400867000178	Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
1400867000179	dihydrodipicolinate synthase; Region: dapA; TIGR00674
1400867000180	dimer interface [polypeptide binding]; other site
1400867000181	active site
1400867000182	catalytic residue [active]
1400867000183	Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011
1400867000184	Isochorismatase family; Region: Isochorismatase; pfam00857
1400867000185	catalytic triad [active]
1400867000186	metal binding site [ion binding]; metal-binding site
1400867000187	conserved cis-peptide bond; other site
1400867000188	Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385
1400867000189	Sodium Bile acid symporter family; Region: SBF; pfam01758
1400867000190	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131
1400867000191	putative efflux protein, MATE family; Region: matE; TIGR00797
1400867000192	cation binding site [ion binding]; other site
1400867000193	Uncharacterized conserved protein [Function unknown]; Region: COG1683
1400867000194	4-hydroxyphenylpyruvate dioxygenase and related hemolysins [Amino acid transport and metabolism / General function prediction only]; Region: COG3185
1400867000195	N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342
1400867000196	dimer interface [polypeptide binding]; other site
1400867000197	C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250
1400867000198	active site
1400867000199	Fe binding site [ion binding]; other site
1400867000200	IclR helix-turn-helix domain; Region: HTH_IclR; cl17605
1400867000201	Transcriptional regulator [Transcription]; Region: IclR; COG1414
1400867000202	Bacterial transcriptional regulator; Region: IclR; pfam01614
1400867000203	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1400867000204	N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346
1400867000205	Zn binding site [ion binding]; other site
1400867000206	GST_N family, Class Zeta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Zeta; cd03042
1400867000207	maleylacetoacetate isomerase; Region: maiA; TIGR01262
1400867000208	C-terminal domain interface [polypeptide binding]; other site
1400867000209	GSH binding site (G-site) [chemical binding]; other site
1400867000210	putative dimer interface [polypeptide binding]; other site
1400867000211	C-terminal, alpha helical domain of Class Zeta Glutathione S-transferases; Region: GST_C_Zeta; cd03191
1400867000212	dimer interface [polypeptide binding]; other site
1400867000213	N-terminal domain interface [polypeptide binding]; other site
1400867000214	maleylacetoacetate (MAA) substrate binding site (H site) [chemical binding]; other site
1400867000215	fumarylacetoacetase; Region: PLN02856
1400867000216	Domain of unknown function (DUF1969); Region: DUF1969; pfam09298
1400867000217	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
1400867000218	aromatic amino acid transporter; Provisional; Region: PRK10238
1400867000219	Peptidase M15; Region: Peptidase_M15_3; cl01194
1400867000220	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
1400867000221	CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492
1400867000222	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833
1400867000223	Acyltransferase family; Region: Acyl_transf_3; pfam01757
1400867000224	histidine utilization repressor, proteobacterial; Region: his_ut_repres; TIGR02018
1400867000225	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1400867000226	DNA-binding site [nucleotide binding]; DNA binding site
1400867000227	UTRA domain; Region: UTRA; pfam07702
1400867000228	HutD; Region: HutD; pfam05962
1400867000229	urocanate hydratase; Provisional; Region: PRK05414
1400867000230	Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332
1400867000231	active sites [active]
1400867000232	tetramer interface [polypeptide binding]; other site
1400867000233	putative proline-specific permease; Provisional; Region: proY; PRK10580
1400867000234	imidazolonepropionase; Validated; Region: PRK09356
1400867000235	Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296
1400867000236	active site
1400867000237	agmatinase; Region: agmatinase; TIGR01230
1400867000238	Formimidoylglutamase or HutE; Region: Formimidoylglutamase; cd09988
1400867000239	putative active site [active]
1400867000240	putative metal binding site [ion binding]; other site
1400867000241	Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960
1400867000242	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
1400867000243	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1400867000244	motif II; other site
1400867000245	glutamate racemase; Provisional; Region: PRK00865
1400867000246	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
1400867000247	glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331
1400867000248	Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans).  The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714
1400867000249	glutaminase active site [active]
1400867000250	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
1400867000251	dimer interface [polypeptide binding]; other site
1400867000252	active site
1400867000253	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
1400867000254	dimer interface [polypeptide binding]; other site
1400867000255	active site
1400867000256	N-acetylglucosamine-1-phosphate uridyltransferase (contains nucleotidyltransferase and I-patch acetyltransferase domains) [Cell envelope biogenesis, outer membrane]; Region: GlmU; COG1207
1400867000257	N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540
1400867000258	Substrate binding site; other site
1400867000259	Mg++ binding site; other site
1400867000260	N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353
1400867000261	active site
1400867000262	substrate binding site [chemical binding]; other site
1400867000263	CoA binding site [chemical binding]; other site
1400867000264	Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971
1400867000265	tetramer interfaces [polypeptide binding]; other site
1400867000266	binuclear metal-binding site [ion binding]; other site
1400867000267	thiamine monophosphate kinase; Provisional; Region: PRK05731
1400867000268	ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194
1400867000269	ATP binding site [chemical binding]; other site
1400867000270	dimerization interface [polypeptide binding]; other site
1400867000271	transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202
1400867000272	lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209
1400867000273	homopentamer interface [polypeptide binding]; other site
1400867000274	active site
1400867000275	bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II-like protein; Provisional; Region: PRK14019
1400867000276	3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926
1400867000277	GTP cyclohydrolase II; Region: GTP_cyclohydro2; pfam00925
1400867000278	dimerization interface [polypeptide binding]; other site
1400867000279	active site
1400867000280	Domain of unknown function (DUF4175); Region: DUF4175; pfam13779
1400867000281	CT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_1; cd04870
1400867000282	ACT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_2; cd04871
1400867000283	phosphoserine phosphatase SerB; Region: serB; TIGR00338
1400867000284	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1400867000285	motif II; other site
1400867000286	D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563
1400867000287	putative active site [active]
1400867000288	dimerization interface [polypeptide binding]; other site
1400867000289	putative tRNAtyr binding site [nucleotide binding]; other site
1400867000290	Clade 1 of the heme-binding enzyme catalase; Region: catalase_clade_1; cd08154
1400867000291	Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753
1400867000292	tetramer interface [polypeptide binding]; other site
1400867000293	heme binding pocket [chemical binding]; other site
1400867000294	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
1400867000295	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
1400867000296	nicotinate phosphoribosyltransferase; Region: NAPRTase; TIGR01514
1400867000297	Nicotinate phosphoribosyltransferase (NAPRTase), related to PncB. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting; Region: PncB_like; cd01401
1400867000298	active site
1400867000299	Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897
1400867000300	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
1400867000301	active site residue [active]
1400867000302	Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449
1400867000303	active site residue [active]
1400867000304	phosphatidylserine decarboxylase; Reviewed; Region: psd; PRK00044
1400867000305	Predicted acetamidase/formamidase [Energy production and conversion]; Region: COG2421
1400867000306	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
1400867000307	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
1400867000308	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
1400867000309	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
1400867000310	Secretory lipase; Region: LIP; pfam03583
1400867000311	alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561
1400867000312	Domain of unknown function (DUF3329); Region: DUF3329; pfam11808
1400867000313	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
1400867000314	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1400867000315	putative active site [active]
1400867000316	heme pocket [chemical binding]; other site
1400867000317	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1400867000318	dimer interface [polypeptide binding]; other site
1400867000319	phosphorylation site [posttranslational modification]
1400867000320	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1400867000321	ATP binding site [chemical binding]; other site
1400867000322	Mg2+ binding site [ion binding]; other site
1400867000323	G-X-G motif; other site
1400867000324	phosphate regulon transcriptional regulatory protein PhoB; Region: PhoB; TIGR02154
1400867000325	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1400867000326	active site
1400867000327	phosphorylation site [posttranslational modification]
1400867000328	intermolecular recognition site; other site
1400867000329	dimerization interface [polypeptide binding]; other site
1400867000330	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1400867000331	DNA binding site [nucleotide binding]
1400867000332	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1400867000333	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1400867000334	short chain dehydrogenase; Provisional; Region: PRK07832
1400867000335	NAD(P) binding site [chemical binding]; other site
1400867000336	active site
1400867000337	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
1400867000338	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138
1400867000339	methionine aminotransferase; Validated; Region: PRK09082
1400867000340	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1400867000341	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1400867000342	homodimer interface [polypeptide binding]; other site
1400867000343	catalytic residue [active]
1400867000344	Protein of unknown function (DUF445); Region: DUF445; pfam04286
1400867000345	Bacterial protein of unknown function (DUF924); Region: DUF924; pfam06041
1400867000346	Glutamate-cysteine ligase; Region: Glu_cys_ligase; cl17352
1400867000347	Disulfide bond formation protein DsbB; Region: DsbB; pfam02600
1400867000348	Uncharacterized protein conserved in bacteria [Function unknown]; Region: VgrG; COG3501
1400867000349	Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954
1400867000350	Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717
1400867000351	Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296
1400867000352	Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; pfam10106
1400867000353	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1400867000354	Protein of unknown function (DUF1311); Region: DUF1311; pfam07007
1400867000355	Bacterial SH3 domain; Region: SH3_3; cl17532
1400867000356	PGAP1-like protein; Region: PGAP1; pfam07819
1400867000357	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
1400867000358	Uncharacterized protein family (UPF0227); Region: UPF0227; cl14886
1400867000359	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
1400867000360	DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559
1400867000361	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1400867000362	ATP binding site [chemical binding]; other site
1400867000363	Mg2+ binding site [ion binding]; other site
1400867000364	G-X-G motif; other site
1400867000365	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
1400867000366	anchoring element; other site
1400867000367	dimer interface [polypeptide binding]; other site
1400867000368	ATP binding site [chemical binding]; other site
1400867000369	Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718
1400867000370	active site
1400867000371	metal binding site [ion binding]; metal-binding site
1400867000372	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
1400867000373	3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830
1400867000374	classical (c) SDRs; Region: SDR_c; cd05233
1400867000375	NAD(P) binding site [chemical binding]; other site
1400867000376	active site
1400867000377	ureidoglycolate hydrolase; Provisional; Region: PRK03606
1400867000378	Ureidoglycolate hydrolase [Nucleotide transport and metabolism]; Region: DAL3; COG3194
1400867000379	allantoicase; Provisional; Region: PRK13257
1400867000380	Allantoicase repeat; Region: Allantoicase; pfam03561
1400867000381	Allantoicase repeat; Region: Allantoicase; pfam03561
1400867000382	hypothetical protein; Provisional; Region: PRK07236
1400867000383	FAD binding domain; Region: FAD_binding_3; pfam01494
1400867000384	Nucleoside-specific channel-forming protein, Tsx; Region: Channel_Tsx; cl04114
1400867000385	xanthine permease; Region: pbuX; TIGR03173
1400867000386	HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822
1400867000387	active site
1400867000388	homotetramer interface [polypeptide binding]; other site
1400867000389	putative OHCU decarboxylase; Provisional; Region: PRK13798
1400867000390	putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212
1400867000391	Catalytic domain of bacterial PuuE allantoinases, Schizosaccharomyces pombe chitin deacetylase 1 (SpCDA1), and similar proteins; Region: CE4_PuuE_SpCDA1; cd10977
1400867000392	active site
1400867000393	catalytic site [active]
1400867000394	tetramer interface [polypeptide binding]; other site
1400867000395	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cl00250
1400867000396	30S subunit binding site; other site
1400867000397	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
1400867000398	Ankyrin repeats (many copies); Region: Ank_5; pfam13857
1400867000399	Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; pfam13557
1400867000400	thiol:disulfide interchange protein precursor; Provisional; Region: dipZ; PRK00293
1400867000401	Disulphide bond corrector protein DsbC; Region: DsbC; pfam11412
1400867000402	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788
1400867000403	DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953
1400867000404	DsbD alpha interface [polypeptide binding]; other site
1400867000405	catalytic residues [active]
1400867000406	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1400867000407	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1400867000408	metal binding site [ion binding]; metal-binding site
1400867000409	active site
1400867000410	I-site; other site
1400867000411	Protein of unknown function (DUF2424); Region: DUF2424; pfam10340
1400867000412	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
1400867000413	Uncharacterized protein conserved in bacteria (DUF2147); Region: DUF2147; pfam09917
1400867000414	Arsenate Reductase (ArsC) family, Yffb subfamily; Yffb is an uncharacterized bacterial protein encoded by the yffb gene, related to the thioredoxin-fold arsenic reductases, ArsC. The structure of Yffb and the conservation of the catalytic cysteine...; Region: ArsC_Yffb; cd03035
1400867000415	ArsC family; Region: ArsC; pfam03960
1400867000416	putative catalytic residues [active]
1400867000417	Neisseria meningitides Nape-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Nape_like_AP-endo; cd10281
1400867000418	putative active site [active]
1400867000419	putative catalytic site [active]
1400867000420	putative DNA binding site [nucleotide binding]; other site
1400867000421	putative phosphate binding site [ion binding]; other site
1400867000422	metal binding site A [ion binding]; metal-binding site
1400867000423	putative AP binding site [nucleotide binding]; other site
1400867000424	putative metal binding site B [ion binding]; other site
1400867000425	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1400867000426	active site
1400867000427	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
1400867000428	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
1400867000429	N-terminal plug; other site
1400867000430	ligand-binding site [chemical binding]; other site
1400867000431	Domain of unknown function (DUF1737); Region: DUF1737; pfam08410
1400867000432	glutathione synthetase; Provisional; Region: PRK05246
1400867000433	Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951
1400867000434	Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955
1400867000435	undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726
1400867000436	MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785
1400867000437	active site
1400867000438	homodimer interface [polypeptide binding]; other site
1400867000439	UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421
1400867000440	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
1400867000441	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
1400867000442	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
1400867000443	D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372
1400867000444	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
1400867000445	ATP-grasp domain; Region: ATP-grasp_4; cl17255
1400867000446	POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478
1400867000447	Cell division protein FtsQ; Region: FtsQ; pfam03799
1400867000448	Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849
1400867000449	Cell division protein FtsA; Region: FtsA; smart00842
1400867000450	Cell division protein FtsA; Region: FtsA; pfam14450
1400867000451	cell division protein FtsZ; Validated; Region: PRK09330
1400867000452	FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes.  FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201
1400867000453	nucleotide binding site [chemical binding]; other site
1400867000454	SulA interaction site; other site
1400867000455	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186
1400867000456	UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331
1400867000457	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
1400867000458	Peptidase family M23; Region: Peptidase_M23; pfam01551
1400867000459	pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405
1400867000460	Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017
1400867000461	dimer interface [polypeptide binding]; other site
1400867000462	TPP-binding site [chemical binding]; other site
1400867000463	Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410
1400867000464	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
1400867000465	pyruvate dehydrogenase dihydrolipoyltransacetylase; Validated; Region: aceF; PRK11854
1400867000466	E3 interaction surface; other site
1400867000467	lipoyl attachment site [posttranslational modification]; other site
1400867000468	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
1400867000469	E3 interaction surface; other site
1400867000470	lipoyl attachment site [posttranslational modification]; other site
1400867000471	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
1400867000472	E3 interaction surface; other site
1400867000473	lipoyl attachment site [posttranslational modification]; other site
1400867000474	e3 binding domain; Region: E3_binding; pfam02817
1400867000475	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
1400867000476	Predicted membrane protein [Function unknown]; Region: COG2119
1400867000477	Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169
1400867000478	Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169
1400867000479	ferrichrome outer membrane transporter; Provisional; Region: PRK10044
1400867000480	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
1400867000481	N-terminal plug; other site
1400867000482	ligand-binding site [chemical binding]; other site
1400867000483	Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426
1400867000484	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
1400867000485	Predicted Fe-S-cluster oxidoreductase [General function prediction only]; Region: COG0727
1400867000486	inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567
1400867000487	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
1400867000488	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein.  IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601
1400867000489	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
1400867000490	active site
1400867000491	phosphoglucosamine mutase; Provisional; Region: glmM; PRK10887
1400867000492	GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802
1400867000493	active site
1400867000494	substrate binding site [chemical binding]; other site
1400867000495	metal binding site [ion binding]; metal-binding site
1400867000496	pyridoxamine-phosphate oxidase; Region: pdxH; TIGR00558
1400867000497	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243
1400867000498	Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590
1400867000499	ssDNA exonuclease RecJ; Provisional; Region: PRK11070
1400867000500	DHH family; Region: DHH; pfam01368
1400867000501	DHHA1 domain; Region: DHHA1; pfam02272
1400867000502	peptide chain release factor 2; Provisional; Region: PRK08787
1400867000503	This domain is found in peptide chain release factors; Region: PCRF; smart00937
1400867000504	RF-1 domain; Region: RF-1; pfam00472
1400867000505	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1400867000506	putative DNA binding site [nucleotide binding]; other site
1400867000507	dimerization interface [polypeptide binding]; other site
1400867000508	putative Zn2+ binding site [ion binding]; other site
1400867000509	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
1400867000510	Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933
1400867000511	FMN binding site [chemical binding]; other site
1400867000512	active site
1400867000513	substrate binding site [chemical binding]; other site
1400867000514	catalytic residue [active]
1400867000515	3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749
1400867000516	3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413
1400867000517	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
1400867000518	RNA methyltransferase, RsmE family; Region: TIGR00046
1400867000519	16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713
1400867000520	Fucose 4-O-acetylase and related acetyltransferases [Carbohydrate transport and metabolism]; Region: NolL; COG3594
1400867000521	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
1400867000522	Mechanosensitive ion channel; Region: MS_channel; pfam00924
1400867000523	Protein of unknown function (DUF805); Region: DUF805; pfam05656
1400867000524	acetyl-CoA synthetase; Provisional; Region: PRK00174
1400867000525	Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966
1400867000526	active site
1400867000527	CoA binding site [chemical binding]; other site
1400867000528	acyl-activating enzyme (AAE) consensus motif; other site
1400867000529	AMP binding site [chemical binding]; other site
1400867000530	acetate binding site [chemical binding]; other site
1400867000531	Isochorismatase family; Region: Isochorismatase; pfam00857
1400867000532	Nicotinamidase_ related amidohydrolases.  Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014
1400867000533	catalytic triad [active]
1400867000534	conserved cis-peptide bond; other site
1400867000535	Peroxidase, family 2; Region: Peroxidase_2; pfam01328
1400867000536	helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344
1400867000537	AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404
1400867000538	dimerization interface [polypeptide binding]; other site
1400867000539	putative DNA binding site [nucleotide binding]; other site
1400867000540	putative Zn2+ binding site [ion binding]; other site
1400867000541	AsnC family; Region: AsnC_trans_reg; pfam01037
1400867000542	dimethyl sulfone monooxygenase SfnG; Region: LLM_DMSO2_sfnG; TIGR04021
1400867000543	Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094
1400867000544	active site
1400867000545	dimer interface [polypeptide binding]; other site
1400867000546	non-prolyl cis peptide bond; other site
1400867000547	insertion regions; other site
1400867000548	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
1400867000549	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
1400867000550	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1400867000551	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1400867000552	active site
1400867000553	phosphorylation site [posttranslational modification]
1400867000554	intermolecular recognition site; other site
1400867000555	dimerization interface [polypeptide binding]; other site
1400867000556	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1400867000557	DNA binding residues [nucleotide binding]
1400867000558	dimerization interface [polypeptide binding]; other site
1400867000559	Na+/proline symporter [Amino acid transport and metabolism / General function prediction only]; Region: PutP; COG0591
1400867000560	Na binding site [ion binding]; other site
1400867000561	PAS fold; Region: PAS_7; pfam12860
1400867000562	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
1400867000563	putative active site [active]
1400867000564	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1400867000565	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1400867000566	dimer interface [polypeptide binding]; other site
1400867000567	phosphorylation site [posttranslational modification]
1400867000568	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1400867000569	ATP binding site [chemical binding]; other site
1400867000570	Mg2+ binding site [ion binding]; other site
1400867000571	G-X-G motif; other site
1400867000572	Response regulator receiver domain; Region: Response_reg; pfam00072
1400867000573	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1400867000574	active site
1400867000575	phosphorylation site [posttranslational modification]
1400867000576	intermolecular recognition site; other site
1400867000577	dimerization interface [polypeptide binding]; other site
1400867000578	Protein of unknown function, DUF485; Region: DUF485; pfam04341
1400867000579	Predicted symporter [General function prediction only]; Region: DhlC; COG4147
1400867000580	Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480
1400867000581	Na binding site [ion binding]; other site
1400867000582	BCCT family transporter; Region: BCCT; pfam02028
1400867000583	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1400867000584	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1400867000585	metal binding site [ion binding]; metal-binding site
1400867000586	active site
1400867000587	I-site; other site
1400867000588	excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349
1400867000589	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
1400867000590	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
1400867000591	ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271
1400867000592	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1400867000593	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1400867000594	2-enoyl thioester reductase (ETR) like proteins, child 2; Region: ETR_like_2; cd08292
1400867000595	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
1400867000596	putative NAD(P) binding site [chemical binding]; other site
1400867000597	putative dimer interface [polypeptide binding]; other site
1400867000598	Protein of unknown function (DUF1304); Region: DUF1304; pfam06993
1400867000599	GlpM protein; Region: GlpM; pfam06942
1400867000600	Putative transcription activator [Transcription]; Region: TenA; COG0819
1400867000601	hypothetical protein; Provisional; Region: PRK14013
1400867000602	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1400867000603	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1400867000604	putative substrate translocation pore; other site
1400867000605	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
1400867000606	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
1400867000607	dimer interface [polypeptide binding]; other site
1400867000608	ssDNA binding site [nucleotide binding]; other site
1400867000609	tetramer (dimer of dimers) interface [polypeptide binding]; other site
1400867000610	Branched-chain amino acid transport protein (AzlD); Region: AzlD; pfam05437
1400867000611	AzlC protein; Region: AzlC; cl00570
1400867000612	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1400867000613	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1400867000614	non-specific DNA binding site [nucleotide binding]; other site
1400867000615	salt bridge; other site
1400867000616	sequence-specific DNA binding site [nucleotide binding]; other site
1400867000617	Cupin domain; Region: Cupin_2; pfam07883
1400867000618	gamma-aminobutyrate permease; Region: GABAperm; TIGR01773
1400867000619	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
1400867000620	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1400867000621	DNA-binding site [nucleotide binding]; DNA binding site
1400867000622	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1400867000623	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1400867000624	homodimer interface [polypeptide binding]; other site
1400867000625	catalytic residue [active]
1400867000626	4-aminobutyrate aminotransferase; Provisional; Region: PRK06777
1400867000627	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
1400867000628	inhibitor-cofactor binding pocket; inhibition site
1400867000629	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1400867000630	catalytic residue [active]
1400867000631	succinic semialdehyde dehydrogenase; Region: PLN02278
1400867000632	Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103
1400867000633	tetramerization interface [polypeptide binding]; other site
1400867000634	NAD(P) binding site [chemical binding]; other site
1400867000635	catalytic residues [active]
1400867000636	LysR family transcriptional regulator; Provisional; Region: PRK14997
1400867000637	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1400867000638	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1400867000639	dimerization interface [polypeptide binding]; other site
1400867000640	Isochorismatase family; Region: Isochorismatase; pfam00857
1400867000641	YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012
1400867000642	catalytic triad [active]
1400867000643	dimer interface [polypeptide binding]; other site
1400867000644	conserved cis-peptide bond; other site
1400867000645	Pirin-related protein [General function prediction only]; Region: COG1741
1400867000646	Pirin; Region: Pirin; pfam02678
1400867000647	Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726
1400867000648	Predicted NAD/FAD-binding protein [General function prediction only]; Region: COG2907
1400867000649	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
1400867000650	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1400867000651	S-adenosylmethionine binding site [chemical binding]; other site
1400867000652	Uncharacterized conserved protein [Function unknown]; Region: COG3791
1400867000653	The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid.  N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467
1400867000654	active site
1400867000655	Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; cl01733
1400867000656	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1400867000657	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1400867000658	putative substrate translocation pore; other site
1400867000659	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1400867000660	DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906
1400867000661	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1400867000662	The C-terminal substrate binding domain of LysR-type transcrptional regulator BudR, which is responsible for activation of the expression of the butanediol operon genes; contains the type 2 periplasmic binding fold; Region: PBP2_BudR; cd08451
1400867000663	putative dimerization interface [polypeptide binding]; other site
1400867000664	putative substrate binding pocket [chemical binding]; other site
1400867000665	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
1400867000666	EamA-like transporter family; Region: EamA; pfam00892
1400867000667	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1400867000668	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
1400867000669	active site
1400867000670	catalytic tetrad [active]
1400867000671	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1400867000672	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1400867000673	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1400867000674	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1400867000675	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
1400867000676	Sel1-like repeats; Region: SEL1; smart00671
1400867000677	Sel1 repeat; Region: Sel1; cl02723
1400867000678	Predicted transcriptional regulators [Transcription]; Region: COG1733
1400867000679	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
1400867000680	Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525
1400867000681	K+ transporter [Inorganic ion transport and metabolism]; Region: Kup; COG3158
1400867000682	potassium uptake protein; Region: kup; TIGR00794
1400867000683	DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases.  They exists as monomers and homodimers; Region: NUC; cd00091
1400867000684	DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892
1400867000685	active site
1400867000686	substrate binding site [chemical binding]; other site
1400867000687	Mg2+ binding site [ion binding]; other site
1400867000688	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
1400867000689	Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333
1400867000690	amphipathic channel; other site
1400867000691	Asn-Pro-Ala signature motifs; other site
1400867000692	Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625
1400867000693	Helix-turn-helix domain; Region: HTH_18; pfam12833
1400867000694	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1400867000695	The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731
1400867000696	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
1400867000697	substrate binding site [chemical binding]; other site
1400867000698	glutamase interaction surface [polypeptide binding]; other site
1400867000699	Homoserine Kinase, type II. Homoserine kinase is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and...; Region: HomoserineK_II; cd05153
1400867000700	Phosphotransferase enzyme family; Region: APH; pfam01636
1400867000701	putative active site [active]
1400867000702	putative substrate binding site [chemical binding]; other site
1400867000703	ATP binding site [chemical binding]; other site
1400867000704	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
1400867000705	DNA-binding site [nucleotide binding]; DNA binding site
1400867000706	RNA-binding motif; other site
1400867000707	Protein of unknown function (DUF1294); Region: DUF1294; pfam06961
1400867000708	Predicted membrane protein [Function unknown]; Region: COG3671
1400867000709	EamA-like transporter family; Region: EamA; pfam00892
1400867000710	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
1400867000711	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1400867000712	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1400867000713	non-specific DNA binding site [nucleotide binding]; other site
1400867000714	salt bridge; other site
1400867000715	sequence-specific DNA binding site [nucleotide binding]; other site
1400867000716	HisA.  Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732
1400867000717	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
1400867000718	catalytic residues [active]
1400867000719	DEDDy 3'-5' exonuclease domain of WRN and similar proteins; Region: WRN_exo; cd06141
1400867000720	catalytic site [active]
1400867000721	putative active site [active]
1400867000722	putative substrate binding site [chemical binding]; other site
1400867000723	Protein of unknown function (DUF805); Region: DUF805; pfam05656
1400867000724	imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141
1400867000725	Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748
1400867000726	putative active site [active]
1400867000727	oxyanion strand; other site
1400867000728	catalytic triad [active]
1400867000729	Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914
1400867000730	putative active site pocket [active]
1400867000731	4-fold oligomerization interface [polypeptide binding]; other site
1400867000732	metal binding residues [ion binding]; metal-binding site
1400867000733	3-fold/trimer interface [polypeptide binding]; other site
1400867000734	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1400867000735	Coenzyme A binding pocket [chemical binding]; other site
1400867000736	putative acetyltransferase; Provisional; Region: PRK03624
1400867000737	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1400867000738	Coenzyme A binding pocket [chemical binding]; other site
1400867000739	Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550
1400867000740	succinate CoA transferase; Region: YgfH_subfam; TIGR03458
1400867000741	Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336
1400867000742	osmolarity sensor protein; Provisional; Region: envZ; PRK09467
1400867000743	HAMP domain; Region: HAMP; pfam00672
1400867000744	dimerization interface [polypeptide binding]; other site
1400867000745	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1400867000746	dimer interface [polypeptide binding]; other site
1400867000747	phosphorylation site [posttranslational modification]
1400867000748	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1400867000749	ATP binding site [chemical binding]; other site
1400867000750	Mg2+ binding site [ion binding]; other site
1400867000751	G-X-G motif; other site
1400867000752	osmolarity response regulator; Provisional; Region: ompR; PRK09468
1400867000753	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1400867000754	active site
1400867000755	phosphorylation site [posttranslational modification]
1400867000756	intermolecular recognition site; other site
1400867000757	dimerization interface [polypeptide binding]; other site
1400867000758	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1400867000759	DNA binding site [nucleotide binding]
1400867000760	Transcriptional accessory protein [Transcription]; Region: Tex; COG2183
1400867000761	Tex-like protein N-terminal domain; Region: Tex_N; pfam09371
1400867000762	Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732
1400867000763	S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685
1400867000764	RNA binding site [nucleotide binding]; other site
1400867000765	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
1400867000766	Sulfate transporter family; Region: Sulfate_transp; pfam00916
1400867000767	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378
1400867000768	active site clefts [active]
1400867000769	zinc binding site [ion binding]; other site
1400867000770	dimer interface [polypeptide binding]; other site
1400867000771	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
1400867000772	classical (c) SDRs; Region: SDR_c; cd05233
1400867000773	NAD(P) binding site [chemical binding]; other site
1400867000774	active site
1400867000775	O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK06084
1400867000776	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
1400867000777	homodimer interface [polypeptide binding]; other site
1400867000778	substrate-cofactor binding pocket; other site
1400867000779	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1400867000780	catalytic residue [active]
1400867000781	putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819
1400867000782	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1400867000783	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1400867000784	ABC transporter; Region: ABC_tran_2; pfam12848
1400867000785	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1400867000786	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
1400867000787	Sel1-like repeats; Region: SEL1; smart00671
1400867000788	hypothetical protein; Provisional; Region: PRK10215
1400867000789	Outer membrane efflux protein; Region: OEP; pfam02321
1400867000790	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
1400867000791	Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999
1400867000792	HlyD family secretion protein; Region: HlyD_3; pfam13437
1400867000793	heavy metal efflux pump, CzcA family; Region: 2A0601; TIGR00914
1400867000794	Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230
1400867000795	S-methylmethionine transporter; Provisional; Region: PRK11387
1400867000796	glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
1400867000797	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
1400867000798	active site
1400867000799	HIGH motif; other site
1400867000800	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
1400867000801	active site
1400867000802	KMSKS motif; other site
1400867000803	ABC-type sulfate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: Sbp; COG1613
1400867000804	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
1400867000805	16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050
1400867000806	MraW methylase family; Region: Methyltransf_5; cl17771
1400867000807	Cell division protein FtsL; Region: FtsL; pfam04999
1400867000808	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
1400867000809	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
1400867000810	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
1400867000811	UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139
1400867000812	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
1400867000813	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
1400867000814	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
1400867000815	UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Region: murF; TIGR01143
1400867000816	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
1400867000817	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
1400867000818	phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108
1400867000819	Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852
1400867000820	Mg++ binding site [ion binding]; other site
1400867000821	putative catalytic motif [active]
1400867000822	putative substrate binding site [chemical binding]; other site
1400867000823	23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088
1400867000824	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1400867000825	S-adenosylmethionine binding site [chemical binding]; other site
1400867000826	Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane]; Region: MrcA; COG5009
1400867000827	Transglycosylase; Region: Transgly; pfam00912
1400867000828	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
1400867000829	Competence protein A; Region: Competence_A; pfam11104
1400867000830	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
1400867000831	Tfp pilus assembly protein PilN [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilN; COG3166
1400867000832	Fimbrial assembly protein (PilN); Region: PilN; pfam05137
1400867000833	Pilus assembly protein, PilO; Region: PilO; pfam04350
1400867000834	Tfp pilus assembly protein PilP [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilP; COG3168
1400867000835	Pilus assembly protein, PilP; Region: PilP; pfam04351
1400867000836	AMIN domain; Region: AMIN; pfam11741
1400867000837	type IV pilus secretin (or competence protein) PilQ; Region: IV_pilus_PilQ; TIGR02515
1400867000838	Secretin and TonB N terminus short domain; Region: STN; smart00965
1400867000839	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
1400867000840	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
1400867000841	shikimate kinase; Reviewed; Region: aroK; PRK00131
1400867000842	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
1400867000843	ADP binding site [chemical binding]; other site
1400867000844	magnesium binding site [ion binding]; other site
1400867000845	putative shikimate binding site; other site
1400867000846	Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195
1400867000847	active site
1400867000848	dimer interface [polypeptide binding]; other site
1400867000849	metal binding site [ion binding]; metal-binding site
1400867000850	glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750
1400867000851	Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713
1400867000852	active site
1400867000853	dimer interface [polypeptide binding]; other site
1400867000854	Glutamate synthase central domain; Region: Glu_syn_central; pfam04898
1400867000855	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
1400867000856	active site
1400867000857	FMN binding site [chemical binding]; other site
1400867000858	substrate binding site [chemical binding]; other site
1400867000859	3Fe-4S cluster binding site [ion binding]; other site
1400867000860	gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982
1400867000861	domain interface; other site
1400867000862	glutamate synthase small subunit family protein, proteobacterial; Region: gltD_gamma_fam; TIGR01318
1400867000863	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
1400867000864	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1400867000865	Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687
1400867000866	Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118
1400867000867	LemA family; Region: LemA; pfam04011
1400867000868	Repair protein; Region: Repair_PSII; pfam04536
1400867000869	Repair protein; Region: Repair_PSII; pfam04536
1400867000870	Tfp pilus assembly protein, major pilin PilA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilA; COG4969
1400867000871	Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544
1400867000872	Pilin (bacterial filament); Region: Pilin; pfam00114
1400867000873	O-antigen ligase like membrane protein; Region: O-antigen_lig; pfam13425
1400867000874	Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307
1400867000875	O-Antigen ligase; Region: Wzy_C; pfam04932
1400867000876	Domain of unknown function (DUF3366); Region: DUF3366; pfam11846
1400867000877	Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193
1400867000878	Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907
1400867000879	heme binding site [chemical binding]; other site
1400867000880	ferroxidase pore; other site
1400867000881	ferroxidase diiron center [ion binding]; other site
1400867000882	Bacterioferritin-associated ferredoxin [Inorganic ion transport and metabolism]; Region: Bfd; COG2906
1400867000883	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
1400867000884	homotrimer interaction site [polypeptide binding]; other site
1400867000885	putative active site [active]
1400867000886	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
1400867000887	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
1400867000888	Zn2+ binding site [ion binding]; other site
1400867000889	Mg2+ binding site [ion binding]; other site
1400867000890	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
1400867000891	synthetase active site [active]
1400867000892	NTP binding site [chemical binding]; other site
1400867000893	metal binding site [ion binding]; metal-binding site
1400867000894	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
1400867000895	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
1400867000896	ACT domain; Region: ACT_4; pfam13291
1400867000897	DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392
1400867000898	Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194
1400867000899	Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071
1400867000900	catalytic site [active]
1400867000901	G-X2-G-X-G-K; other site
1400867000902	4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045
1400867000903	4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761
1400867000904	Tfp pilus assembly protein FimT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimT; COG4970
1400867000905	type IV pilus modification protein PilV; Region: type_IV_pilV; TIGR02523
1400867000906	von Willebrand factor type A domain; Region: VWA_2; pfam13519
1400867000907	Neisseria PilC beta-propeller domain; Region: Neisseria_PilC; pfam05567
1400867000908	Tfp pilus assembly protein PilE [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilE; COG4968
1400867000909	Tfp pilus assembly protein PilE [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilE; COG4968
1400867000910	30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040
1400867000911	16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122
1400867000912	RimM N-terminal domain; Region: RimM; pfam01782
1400867000913	PRC-barrel domain; Region: PRC; pfam05239
1400867000914	tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026
1400867000915	50S ribosomal protein L19; Provisional; Region: rplS; PRK05338
1400867000916	Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075
1400867000917	Putative serine esterase (DUF676); Region: DUF676; pfam05057
1400867000918	lipase chaperone; Provisional; Region: PRK01294
1400867000919	Proteobacterial lipase chaperone protein; Region: Lipase_chap; pfam03280
1400867000920	tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05033
1400867000921	Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573
1400867000922	RNA binding site [nucleotide binding]; other site
1400867000923	active site
1400867000924	Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157
1400867000925	hypothetical protein; Provisional; Region: PRK10621
1400867000926	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
1400867000927	Hemerythrin-like domain; Region: Hr-like; cd12108
1400867000928	Threonine/homoserine efflux transporter [Amino acid transport and metabolism]; Region: rhtA; COG5006
1400867000929	threonine and homoserine efflux system; Provisional; Region: PRK10532
1400867000930	EamA-like transporter family; Region: EamA; pfam00892
1400867000931	D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790
1400867000932	Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_3; cd12176
1400867000933	ligand binding site [chemical binding]; other site
1400867000934	NAD binding site [chemical binding]; other site
1400867000935	tetramer interface [polypeptide binding]; other site
1400867000936	catalytic site [active]
1400867000937	C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901
1400867000938	L-serine binding site [chemical binding]; other site
1400867000939	ACT domain interface; other site
1400867000940	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
1400867000941	FAD binding domain; Region: FAD_binding_4; pfam01565
1400867000942	Uncharacterized conserved protein [Function unknown]; Region: COG1359
1400867000943	Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249
1400867000944	multidrug efflux system translocase MdfA; Provisional; Region: PRK15402
1400867000945	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1400867000946	putative substrate translocation pore; other site
1400867000947	FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805
1400867000948	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
1400867000949	Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032
1400867000950	Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305
1400867000951	E-class dimer interface [polypeptide binding]; other site
1400867000952	P-class dimer interface [polypeptide binding]; other site
1400867000953	active site
1400867000954	Cu2+ binding site [ion binding]; other site
1400867000955	Zn2+ binding site [ion binding]; other site
1400867000956	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
1400867000957	Domain of unknown function DUF20; Region: UPF0118; pfam01594
1400867000958	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
1400867000959	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
1400867000960	Magnesium ion binding site [ion binding]; other site
1400867000961	Endonuclease related to archaeal Holliday junction resolvase; Region: Endonuc_Holl; cl01958
1400867000962	Methyltransferase domain; Region: Methyltransf_23; pfam13489
1400867000963	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1400867000964	S-adenosylmethionine binding site [chemical binding]; other site
1400867000965	S-methylmethionine transporter; Provisional; Region: PRK11387
1400867000966	Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334
1400867000967	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
1400867000968	NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076
1400867000969	NAD(P) binding site [chemical binding]; other site
1400867000970	bifunctional succinylornithine transaminase/acetylornithine transaminase; Provisional; Region: PRK12381
1400867000971	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
1400867000972	inhibitor-cofactor binding pocket; inhibition site
1400867000973	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1400867000974	catalytic residue [active]
1400867000975	Arginine/ornithine N-succinyltransferase beta subunit [Amino acid transport and metabolism]; Region: AstA; COG3138
1400867000976	Arginine N-succinyltransferase beta subunit; Region: AstA; cl11440
1400867000977	succinylglutamic semialdehyde dehydrogenase; Reviewed; Region: astD; PRK09457
1400867000978	N-succinylglutamate 5-semialdehyde dehydrogenase, AstD-like; Region: ALDH_SGSD_AstD; cd07095
1400867000979	NAD(P) binding site [chemical binding]; other site
1400867000980	catalytic residues [active]
1400867000981	succinylarginine dihydrolase; Provisional; Region: PRK13281
1400867000982	Peptidase M14 Succinylglutamate desuccinylase (ASTE) subfamily; Region: M14_ASTE; cd03855
1400867000983	Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952
1400867000984	putative active site [active]
1400867000985	Zn binding site [ion binding]; other site
1400867000986	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459
1400867000987	active site
1400867000988	catalytic residues [active]
1400867000989	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1400867000990	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1400867000991	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1400867000992	dimerization interface [polypeptide binding]; other site
1400867000993	EamA-like transporter family; Region: EamA; pfam00892
1400867000994	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
1400867000995	EamA-like transporter family; Region: EamA; pfam00892
1400867000996	YCII-related domain; Region: YCII; cl00999
1400867000997	glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233
1400867000998	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
1400867000999	Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733
1400867001000	dimer interface [polypeptide binding]; other site
1400867001001	motif 1; other site
1400867001002	active site
1400867001003	motif 2; other site
1400867001004	motif 3; other site
1400867001005	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1400867001006	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1400867001007	putative substrate translocation pore; other site
1400867001008	putative DNA modification/repair radical SAM protein; Region: rSAM_link_UDG; TIGR03916
1400867001009	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1400867001010	FeS/SAM binding site; other site
1400867001011	probable DNA metabolism protein; Region: SAM_7_link_chp; TIGR03915
1400867001012	CBS-domain-containing membrane protein [Signal transduction mechanisms]; Region: COG3448
1400867001013	HPP family; Region: HPP; pfam04982
1400867001014	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
1400867001015	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the HPP motif domain. These proteins are integral membrane proteins with four transmembrane spanning helices. The function of these proteins is...; Region: CBS_pair_HPP_assoc; cd04600
1400867001016	PspC domain; Region: PspC; pfam04024
1400867001017	hypothetical protein; Provisional; Region: PRK11615
1400867001018	Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418
1400867001019	acyl-CoA dehydrogenase; Provisional; Region: PTZ00456
1400867001020	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
1400867001021	active site
1400867001022	Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806
1400867001023	shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258
1400867001024	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
1400867001025	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
1400867001026	shikimate binding site; other site
1400867001027	NAD(P) binding site [chemical binding]; other site
1400867001028	coproporphyrinogen III oxidase; Provisional; Region: PRK05330
1400867001029	Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; pfam01218
1400867001030	GTP cyclohydrolase II (RibA).  GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641
1400867001031	dimerization interface [polypeptide binding]; other site
1400867001032	active site
1400867001033	1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444
1400867001034	Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007
1400867001035	TPP-binding site; other site
1400867001036	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
1400867001037	PYR/PP interface [polypeptide binding]; other site
1400867001038	dimer interface [polypeptide binding]; other site
1400867001039	TPP binding site [chemical binding]; other site
1400867001040	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
1400867001041	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
1400867001042	IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639
1400867001043	active site
1400867001044	dimerization interface [polypeptide binding]; other site
1400867001045	ATP-dependent RNA helicase RhlE; Provisional; Region: PRK10590
1400867001046	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
1400867001047	ATP binding site [chemical binding]; other site
1400867001048	Mg++ binding site [ion binding]; other site
1400867001049	motif III; other site
1400867001050	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1400867001051	nucleotide binding region [chemical binding]; other site
1400867001052	ATP-binding site [chemical binding]; other site
1400867001053	ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127
1400867001054	ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261
1400867001055	Walker A/P-loop; other site
1400867001056	ATP binding site [chemical binding]; other site
1400867001057	Q-loop/lid; other site
1400867001058	ABC transporter signature motif; other site
1400867001059	Walker B; other site
1400867001060	D-loop; other site
1400867001061	H-loop/switch region; other site
1400867001062	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
1400867001063	Permease; Region: Permease; cl00510
1400867001064	ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463
1400867001065	mce related protein; Region: MCE; pfam02470
1400867001066	Toluene tolerance, Ttg2; Region: Tol_Tol_Ttg2; pfam05494
1400867001067	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
1400867001068	anti sigma factor interaction site; other site
1400867001069	regulatory phosphorylation site [posttranslational modification]; other site
1400867001070	Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598
1400867001071	Escherichia coli Mg2+ transporter CorA_like subgroup; Region: EcCorA-like_1; cd12835
1400867001072	Cl binding site [ion binding]; other site
1400867001073	oligomer interface [polypeptide binding]; other site
1400867001074	Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695
1400867001075	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_31; cd04690
1400867001076	nudix motif; other site
1400867001077	Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040
1400867001078	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1400867001079	active site
1400867001080	ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917
1400867001081	RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488
1400867001082	ssDNA binding site; other site
1400867001083	generic binding surface II; other site
1400867001084	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1400867001085	ATP binding site [chemical binding]; other site
1400867001086	putative Mg++ binding site [ion binding]; other site
1400867001087	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1400867001088	nucleotide binding region [chemical binding]; other site
1400867001089	ATP-binding site [chemical binding]; other site
1400867001090	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1400867001091	NADH(P)-binding; Region: NAD_binding_10; pfam13460
1400867001092	NAD(P) binding site [chemical binding]; other site
1400867001093	active site
1400867001094	lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096
1400867001095	glycerol-3-phosphate O-acyltransferase; Region: plsB; TIGR03703
1400867001096	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Region: LPLAT_DHAPAT-like; cd07993
1400867001097	putative acyl-acceptor binding pocket; other site
1400867001098	Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946
1400867001099	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445
1400867001100	active site
1400867001101	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444
1400867001102	catalytic triad [active]
1400867001103	dimer interface [polypeptide binding]; other site
1400867001104	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
1400867001105	Sodium:dicarboxylate symporter family; Region: SDF; pfam00375
1400867001106	Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687
1400867001107	Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118
1400867001108	YihA (EngB) GTPase family; Region: YihA_EngB; cd01876
1400867001109	G1 box; other site
1400867001110	GTP/Mg2+ binding site [chemical binding]; other site
1400867001111	Switch I region; other site
1400867001112	G2 box; other site
1400867001113	G3 box; other site
1400867001114	Switch II region; other site
1400867001115	G4 box; other site
1400867001116	G5 box; other site
1400867001117	Transcriptional regulator; Region: Rrf2; cl17282
1400867001118	Rrf2 family protein; Region: rrf2_super; TIGR00738
1400867001119	Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040
1400867001120	heme-binding site [chemical binding]; other site
1400867001121	Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868
1400867001122	FAD binding pocket [chemical binding]; other site
1400867001123	conserved FAD binding motif [chemical binding]; other site
1400867001124	phosphate binding motif [ion binding]; other site
1400867001125	Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872
1400867001126	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1400867001127	Walker A motif; other site
1400867001128	ATP binding site [chemical binding]; other site
1400867001129	Walker B motif; other site
1400867001130	Zonular occludens toxin (Zot); Region: Zot; cl17485
1400867001131	cystathionine beta-lyase; Provisional; Region: PRK07050
1400867001132	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
1400867001133	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1400867001134	catalytic residue [active]
1400867001135	GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518
1400867001136	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741
1400867001137	catalytic triad [active]
1400867001138	30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596
1400867001139	50S ribosomal protein L3; Validated; Region: rplC; PRK00001
1400867001140	50S ribosomal protein L4; Provisional; Region: rplD; PRK05319
1400867001141	50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738
1400867001142	50S ribosomal protein L2; Validated; Region: rplB; PRK09374
1400867001143	Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181
1400867001144	Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947
1400867001145	30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357
1400867001146	Ribosomal protein L22/L17e.  L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit.  It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336
1400867001147	putative translocon binding site; other site
1400867001148	protein-rRNA interface [nucleotide binding]; other site
1400867001149	30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310
1400867001150	K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3  is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel.  The KH...; Region: 30S_S3_KH; cd02412
1400867001151	G-X-X-G motif; other site
1400867001152	Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189
1400867001153	Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433
1400867001154	23S rRNA interface [nucleotide binding]; other site
1400867001155	5S rRNA interface [nucleotide binding]; other site
1400867001156	putative antibiotic binding site [chemical binding]; other site
1400867001157	L25 interface [polypeptide binding]; other site
1400867001158	L27 interface [polypeptide binding]; other site
1400867001159	Ribosomal L29 protein/HIP.  L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals.  L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427
1400867001160	23S rRNA interface [nucleotide binding]; other site
1400867001161	putative translocon interaction site; other site
1400867001162	signal recognition particle (SRP54) interaction site; other site
1400867001163	L23 interface [polypeptide binding]; other site
1400867001164	trigger factor interaction site; other site
1400867001165	30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610
1400867001166	50S ribosomal protein L14; Validated; Region: rplN; PRK05483
1400867001167	50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004
1400867001168	KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089
1400867001169	RNA binding site [nucleotide binding]; other site
1400867001170	50S ribosomal protein L5; Validated; Region: rplE; PRK00010
1400867001171	Ribosomal protein L5; Region: Ribosomal_L5; pfam00281
1400867001172	ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673
1400867001173	30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881
1400867001174	30S ribosomal protein S8; Validated; Region: rpsH; PRK00136
1400867001175	50S ribosomal protein L6; Validated; Region: rplF; PRK05498
1400867001176	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
1400867001177	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
1400867001178	Ribosomal L18/L5e:  L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432
1400867001179	5S rRNA interface [nucleotide binding]; other site
1400867001180	23S rRNA interface [nucleotide binding]; other site
1400867001181	L5 interface [polypeptide binding]; other site
1400867001182	30S ribosomal protein S5; Validated; Region: rpsE; PRK00550
1400867001183	Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333
1400867001184	Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719
1400867001185	Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658
1400867001186	23S rRNA binding site [nucleotide binding]; other site
1400867001187	50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592
1400867001188	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204
1400867001189	SecY translocase; Region: SecY; pfam00344
1400867001190	Ribosomal protein L36; Region: Ribosomal_L36; pfam00444
1400867001191	30S ribosomal protein S13; Validated; Region: rpsM; PRK05179
1400867001192	30S ribosomal protein S13; Region: bact_S13; TIGR03631
1400867001193	30S ribosomal protein S11; Validated; Region: PRK05309
1400867001194	30S ribosomal protein S4; Validated; Region: rpsD; PRK05327
1400867001195	Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163
1400867001196	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1400867001197	RNA binding surface [nucleotide binding]; other site
1400867001198	DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182
1400867001199	N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928
1400867001200	alphaNTD homodimer interface [polypeptide binding]; other site
1400867001201	alphaNTD - beta interaction site [polypeptide binding]; other site
1400867001202	alphaNTD - beta' interaction site [polypeptide binding]; other site
1400867001203	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118
1400867001204	50S ribosomal protein L17; Validated; Region: rplQ; PRK05591
1400867001205	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
1400867001206	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
1400867001207	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
1400867001208	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
1400867001209	active site
1400867001210	Flavinator of succinate dehydrogenase; Region: Sdh5; pfam03937
1400867001211	rhomboid family GlyGly-CTERM serine protease; Region: rhom_GG_sort; TIGR03902
1400867001212	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274
1400867001213	Probable metal-binding protein (DUF2387); Region: DUF2387; pfam09526
1400867001214	Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339
1400867001215	Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456
1400867001216	active site
1400867001217	Zn binding site [ion binding]; other site
1400867001218	ribonuclease R; Region: RNase_R; TIGR02063
1400867001219	RNB domain; Region: RNB; pfam00773
1400867001220	S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471
1400867001221	RNA binding site [nucleotide binding]; other site
1400867001222	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
1400867001223	Nitroreductase-like family 4.  A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_4; cd02140
1400867001224	dimer interface [polypeptide binding]; other site
1400867001225	FMN binding site [chemical binding]; other site
1400867001226	YcxB-like protein; Region: YcxB; pfam14317
1400867001227	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
1400867001228	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421
1400867001229	Helix-turn-helix domain; Region: HTH_18; pfam12833
1400867001230	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1400867001231	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
1400867001232	EamA-like transporter family; Region: EamA; pfam00892
1400867001233	Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918
1400867001234	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
1400867001235	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
1400867001236	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1400867001237	active site
1400867001238	Protein of unknown function (DUF3108); Region: DUF3108; pfam11306
1400867001239	Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810
1400867001240	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
1400867001241	metal-binding heat shock protein; Provisional; Region: PRK00016
1400867001242	Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702
1400867001243	PhoH-like protein; Region: PhoH; pfam02562
1400867001244	(dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325
1400867001245	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
1400867001246	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1400867001247	FeS/SAM binding site; other site
1400867001248	TRAM domain; Region: TRAM; cl01282
1400867001249	lytic murein transglycosylase; Provisional; Region: PRK11619
1400867001250	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
1400867001251	N-acetyl-D-glucosamine binding site [chemical binding]; other site
1400867001252	catalytic residue [active]
1400867001253	Ribonuclease T2 (RNase T2) is a widespread family of secreted RNases found in every organism examined thus far.  This family includes RNase Rh, RNase MC1, RNase LE, and self-incompatibility RNases (S-RNases).  Plant T2 RNases are expressed during leaf...; Region: RNase_T2_prok; cd01062
1400867001254	B1 nucleotide binding pocket [chemical binding]; other site
1400867001255	B2 nucleotide binding pocket [chemical binding]; other site
1400867001256	CAS motifs; other site
1400867001257	active site
1400867001258	malate dehydrogenase; Provisional; Region: PRK05442
1400867001259	Chloroplast-like malate dehydrogenases; Region: MDH_choloroplast_like; cd01338
1400867001260	NAD(P) binding site [chemical binding]; other site
1400867001261	dimer interface [polypeptide binding]; other site
1400867001262	malate binding site [chemical binding]; other site
1400867001263	Protein of unknown function (DUF2789); Region: DUF2789; pfam10982
1400867001264	Predicted proline hydroxylase [Posttranslational modification, protein turnover, chaperones]; Region: EGL-9; COG3751
1400867001265	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; pfam13640
1400867001266	Protein involved in catabolism of external DNA [General function prediction only]; Region: ComJ; COG2961
1400867001267	Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183
1400867001268	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066
1400867001269	Uncharacterized conserved protein [Function unknown]; Region: COG3791
1400867001270	Protein of unknown function (DUF4256); Region: DUF4256; pfam14066
1400867001271	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
1400867001272	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
1400867001273	active site
1400867001274	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1400867001275	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1400867001276	Protein of unknown function (DUF1446); Region: DUF1446; pfam07287
1400867001277	RUN domain; Region: RUN; cl02689
1400867001278	Trans-2-enoyl-CoA reductase (TER) and 2,4-dienoyl-CoA reductase (DECR), atypical (a) SDR; Region: TER_DECR_SDR_a; cd05369
1400867001279	NAD(P) binding site [chemical binding]; other site
1400867001280	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
1400867001281	substrate binding site [chemical binding]; other site
1400867001282	homotetramer interface [polypeptide binding]; other site
1400867001283	active site
1400867001284	homodimer interface [polypeptide binding]; other site
1400867001285	Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799
1400867001286	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
1400867001287	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
1400867001288	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
1400867001289	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
1400867001290	active site
1400867001291	enoyl-CoA hydratase; Provisional; Region: PRK05995
1400867001292	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
1400867001293	substrate binding site [chemical binding]; other site
1400867001294	oxyanion hole (OAH) forming residues; other site
1400867001295	trimer interface [polypeptide binding]; other site
1400867001296	Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770
1400867001297	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
1400867001298	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
1400867001299	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785
1400867001300	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
1400867001301	carboxyltransferase (CT) interaction site; other site
1400867001302	biotinylation site [posttranslational modification]; other site
1400867001303	ClpXP protease specificity-enhancing factor; Provisional; Region: PRK11798
1400867001304	stringent starvation protein A; Provisional; Region: sspA; PRK09481
1400867001305	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
1400867001306	C-terminal, alpha helical domain of Stringent starvation protein A; Region: GST_C_SspA; cd03186
1400867001307	dimer interface [polypeptide binding]; other site
1400867001308	N-terminal domain interface [polypeptide binding]; other site
1400867001309	30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132
1400867001310	Ribosomal protein L13.  Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392
1400867001311	23S rRNA interface [nucleotide binding]; other site
1400867001312	L3 interface [polypeptide binding]; other site
1400867001313	4-hydroxythreonine-4-phosphate dehydrogenase; Region: pdxA; TIGR00557
1400867001314	4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743
1400867001315	16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274
1400867001316	Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030
1400867001317	diadenosine tetraphosphatase; Reviewed; Region: apaH; PRK00166
1400867001318	Escherichia coli ApaH and related proteins, metallophosphatase domain; Region: MPP_ApaH; cd07422
1400867001319	active site
1400867001320	metal binding site [ion binding]; metal-binding site
1400867001321	Uncharacterized protein conserved in bacteria (DUF2147); Region: DUF2147; pfam09917
1400867001322	LrgB-like family; Region: LrgB; cl00596
1400867001323	GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167
1400867001324	GTP-binding protein HflX; Region: GTP_HflX; TIGR03156
1400867001325	HflX GTPase family; Region: HflX; cd01878
1400867001326	G1 box; other site
1400867001327	GTP/Mg2+ binding site [chemical binding]; other site
1400867001328	Switch I region; other site
1400867001329	G2 box; other site
1400867001330	G3 box; other site
1400867001331	Switch II region; other site
1400867001332	G4 box; other site
1400867001333	G5 box; other site
1400867001334	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
1400867001335	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
1400867001336	putative acyl-acceptor binding pocket; other site
1400867001337	Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502
1400867001338	Putative catalytic domain, repeat 1, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_1; cd09111
1400867001339	putative active site [active]
1400867001340	catalytic site [active]
1400867001341	Putative catalytic domain, repeat 2, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_2; cd09113
1400867001342	putative active site [active]
1400867001343	catalytic site [active]
1400867001344	phosphodiesterase YaeI; Provisional; Region: PRK11340
1400867001345	Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385
1400867001346	putative active site [active]
1400867001347	putative metal binding site [ion binding]; other site
1400867001348	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
1400867001349	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
1400867001350	ligand binding site [chemical binding]; other site
1400867001351	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1400867001352	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1400867001353	metal binding site [ion binding]; metal-binding site
1400867001354	active site
1400867001355	I-site; other site
1400867001356	Domain of unknown function (DUF4154); Region: DUF4154; pfam13689
1400867001357	dihydrolipoamide dehydrogenase; Validated; Region: PRK06292
1400867001358	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1400867001359	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1400867001360	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
1400867001361	Putative phosphatase (DUF442); Region: DUF442; cl17385
1400867001362	Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073
1400867001363	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
1400867001364	thioredoxin 2; Provisional; Region: PRK10996
1400867001365	zinc-ribbon domain; Region: zinc_ribbon_5; cl11777
1400867001366	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
1400867001367	catalytic residues [active]
1400867001368	Brown fat-inducible thioesterase (BFIT).  Brain acyl-CoA hydrolase (BACH).  These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442
1400867001369	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
1400867001370	CoenzymeA binding site [chemical binding]; other site
1400867001371	subunit interaction site [polypeptide binding]; other site
1400867001372	PHB binding site; other site
1400867001373	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666
1400867001374	Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740
1400867001375	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
1400867001376	active site residue [active]
1400867001377	bifunctional tRNA (mnm(5)s(2)U34)-methyltransferase/FAD-dependent cmnm(5)s(2)U34 oxidoreductase; Reviewed; Region: mnmC; PRK01747
1400867001378	Uncharacterized conserved protein [Function unknown]; Region: COG4121
1400867001379	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
1400867001380	YciI-like protein; Reviewed; Region: PRK11370
1400867001381	Intracellular septation protein A; Region: IspA; pfam04279
1400867001382	Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613
1400867001383	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438
1400867001384	active site
1400867001385	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438
1400867001386	Bestrophin, RFP-TM, chloride channel; Region: Bestrophin; pfam01062
1400867001387	hypothetical protein; Reviewed; Region: PRK00024
1400867001388	Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
1400867001389	MPN+ (JAMM) motif; other site
1400867001390	Zinc-binding site [ion binding]; other site
1400867001391	bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579
1400867001392	Flavoprotein; Region: Flavoprotein; pfam02441
1400867001393	DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127
1400867001394	preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022
1400867001395	SecD/SecF GG Motif; Region: Sec_GG; pfam07549
1400867001396	Protein export membrane protein; Region: SecD_SecF; pfam02355
1400867001397	SecD export protein N-terminal TM region; Region: SecD-TM1; pfam13721
1400867001398	preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812
1400867001399	SecD/SecF GG Motif; Region: Sec_GG; pfam07549
1400867001400	protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916
1400867001401	preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585
1400867001402	queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112
1400867001403	Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343
1400867001404	LemA family; Region: LemA; cl00742
1400867001405	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147
1400867001406	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113
1400867001407	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1400867001408	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1400867001409	dimer interface [polypeptide binding]; other site
1400867001410	phosphorylation site [posttranslational modification]
1400867001411	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1400867001412	ATP binding site [chemical binding]; other site
1400867001413	Mg2+ binding site [ion binding]; other site
1400867001414	G-X-G motif; other site
1400867001415	bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Reviewed; Region: PRK11072
1400867001416	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
1400867001417	metal binding triad; other site
1400867001418	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
1400867001419	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
1400867001420	metal binding triad; other site
1400867001421	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
1400867001422	BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids  leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557
1400867001423	homodimer interface [polypeptide binding]; other site
1400867001424	substrate-cofactor binding pocket; other site
1400867001425	catalytic residue [active]
1400867001426	Predicted nucleoside-diphosphate-sugar epimerase [Cell envelope biogenesis, outer membrane]; Region: COG3660
1400867001427	Mitochondrial fission ELM1; Region: Mito_fiss_Elm1; pfam06258
1400867001428	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
1400867001429	Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918
1400867001430	putative active site [active]
1400867001431	putative metal binding site [ion binding]; other site
1400867001432	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1400867001433	This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811
1400867001434	putative ADP-binding pocket [chemical binding]; other site
1400867001435	Mitochondrial fission ELM1; Region: Mito_fiss_Elm1; pfam06258
1400867001436	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1400867001437	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1400867001438	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1400867001439	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1400867001440	active site
1400867001441	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
1400867001442	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
1400867001443	dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; cl17405
1400867001444	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
1400867001445	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
1400867001446	active site
1400867001447	DUF based on E. rectale Gene description (DUF3880); Region: DUF3880; pfam12996
1400867001448	Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524
1400867001449	aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476
1400867001450	EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317
1400867001451	dimer interface [polypeptide binding]; other site
1400867001452	anticodon binding site; other site
1400867001453	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
1400867001454	homodimer interface [polypeptide binding]; other site
1400867001455	motif 1; other site
1400867001456	active site
1400867001457	motif 2; other site
1400867001458	GAD domain; Region: GAD; pfam02938
1400867001459	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
1400867001460	active site
1400867001461	motif 3; other site
1400867001462	Domain of unknown function (DUF4184); Region: DUF4184; pfam13803
1400867001463	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
1400867001464	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
1400867001465	N-terminal plug; other site
1400867001466	ligand-binding site [chemical binding]; other site
1400867001467	Putative catalytic domain, repeat 1, of uncharacterized phospholipase D-like proteins; Region: PLDc_unchar2_1; cd09129
1400867001468	putative active site [active]
1400867001469	putative catalytic site [active]
1400867001470	Putative catalytic domain, repeat 2, of uncharacterized phospholipase D-like proteins; Region: PLDc_unchar2_2; cd09130
1400867001471	PLD-like domain; Region: PLDc_2; pfam13091
1400867001472	putative active site [active]
1400867001473	putative catalytic site [active]
1400867001474	Domain of unknown function (DUF3315); Region: DUF3315; pfam11776
1400867001475	Predicted membrane protein [Function unknown]; Region: COG3223
1400867001476	acyl-CoA dehydrogenase; Provisional; Region: PTZ00456
1400867001477	Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418
1400867001478	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
1400867001479	active site
1400867001480	Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806
1400867001481	Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418
1400867001482	acyl-CoA dehydrogenase; Provisional; Region: PTZ00456
1400867001483	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
1400867001484	active site
1400867001485	Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806
1400867001486	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1400867001487	dimerization interface [polypeptide binding]; other site
1400867001488	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1400867001489	dimer interface [polypeptide binding]; other site
1400867001490	phosphorylation site [posttranslational modification]
1400867001491	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1400867001492	ATP binding site [chemical binding]; other site
1400867001493	Mg2+ binding site [ion binding]; other site
1400867001494	G-X-G motif; other site
1400867001495	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1400867001496	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1400867001497	active site
1400867001498	phosphorylation site [posttranslational modification]
1400867001499	intermolecular recognition site; other site
1400867001500	dimerization interface [polypeptide binding]; other site
1400867001501	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1400867001502	DNA binding site [nucleotide binding]
1400867001503	Uncharacterized conserved protein [Function unknown]; Region: COG0397
1400867001504	hypothetical protein; Validated; Region: PRK00029
1400867001505	The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505
1400867001506	Fatty acid desaturase; Region: FA_desaturase; pfam00487
1400867001507	Di-iron ligands [ion binding]; other site
1400867001508	META domain; Region: META; pfam03724
1400867001509	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
1400867001510	Glycerophosphodiester phosphodiesterase domain as found in prokaryota and eukaryota, and similar proteins; Region: GDPD; cd08556
1400867001511	active site
1400867001512	catalytic site [active]
1400867001513	metal binding site [ion binding]; metal-binding site
1400867001514	Cobalamin adenosyltransferase; Region: Cob_adeno_trans; pfam01923
1400867001515	Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206
1400867001516	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
1400867001517	N-terminal plug; other site
1400867001518	ligand-binding site [chemical binding]; other site
1400867001519	Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405
1400867001520	active site
1400867001521	tryptophan synthase, beta subunit; Region: trpB; TIGR00263
1400867001522	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
1400867001523	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1400867001524	catalytic residue [active]
1400867001525	Domain of Unknown Function (DUF1543); Region: DUF1543; pfam07566
1400867001526	Protein of unknown function (DUF2804); Region: DUF2804; pfam10974
1400867001527	Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118
1400867001528	Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687
1400867001529	Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625
1400867001530	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1400867001531	tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200
1400867001532	Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724
1400867001533	substrate binding site [chemical binding]; other site
1400867001534	active site
1400867001535	catalytic residues [active]
1400867001536	heterodimer interface [polypeptide binding]; other site
1400867001537	acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654
1400867001538	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
1400867001539	Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285
1400867001540	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
1400867001541	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
1400867001542	Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053
1400867001543	active site
1400867001544	catalytic residues [active]
1400867001545	Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753
1400867001546	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
1400867001547	Peroxiredoxin (PRX) family, 1-cys PRX subfamily; composed of PRXs containing only one conserved cysteine, which serves as the peroxidatic cysteine. They are homodimeric thiol-specific antioxidant (TSA) proteins that confer a protective role in cells by...; Region: PRX_1cys; cd03016
1400867001548	dimer interface [polypeptide binding]; other site
1400867001549	decamer (pentamer of dimers) interface [polypeptide binding]; other site
1400867001550	catalytic triad [active]
1400867001551	preprotein translocase subunit SecA; Reviewed; Region: PRK12904
1400867001552	SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958
1400867001553	SEC-C motif; Region: SEC-C; pfam02810
1400867001554	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1400867001555	metabolite-proton symporter; Region: 2A0106; TIGR00883
1400867001556	putative substrate translocation pore; other site
1400867001557	Haemolysin-III related; Region: HlyIII; cl03831
1400867001558	channel protein, hemolysin III family; Region: hlyIII; TIGR01065
1400867001559	Methyltransferase domain; Region: Methyltransf_31; pfam13847
1400867001560	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1400867001561	S-adenosylmethionine binding site [chemical binding]; other site
1400867001562	Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; pfam13444
1400867001563	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1400867001564	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667
1400867001565	Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208
1400867001566	active site
1400867001567	nucleophile elbow; other site
1400867001568	multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154
1400867001569	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
1400867001570	substrate binding site [chemical binding]; other site
1400867001571	oxyanion hole (OAH) forming residues; other site
1400867001572	trimer interface [polypeptide binding]; other site
1400867001573	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
1400867001574	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
1400867001575	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
1400867001576	acetyl-CoA acetyltransferase; Validated; Region: PRK08242
1400867001577	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
1400867001578	dimer interface [polypeptide binding]; other site
1400867001579	active site
1400867001580	Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625
1400867001581	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1400867001582	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1400867001583	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
1400867001584	CoA-transferase family III; Region: CoA_transf_3; pfam02515
1400867001585	Carbohydrate-selective porin, OprB family; Region: OprB; cl17816
1400867001586	membrane-bound PQQ-dependent dehydrogenase, glucose/quinate/shikimate family; Region: PQQ_membr_DH; TIGR03074
1400867001587	Membrane-bound PQQ-dependent glucose dehydrogenase; Region: PQQ_mGDH; cd10280
1400867001588	Trp docking motif [polypeptide binding]; other site
1400867001589	putative active site [active]
1400867001590	Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155
1400867001591	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
1400867001592	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
1400867001593	Bacterial protein of unknown function (DUF934); Region: DUF934; pfam06073
1400867001594	Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076
1400867001595	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1400867001596	Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588
1400867001597	dimer interface [polypeptide binding]; other site
1400867001598	acetyl-CoA acetyltransferase; Provisional; Region: PRK06954
1400867001599	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
1400867001600	dimer interface [polypeptide binding]; other site
1400867001601	active site
1400867001602	Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830
1400867001603	Type II transport protein GspH; Region: GspH; pfam12019
1400867001604	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505
1400867001605	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
1400867001606	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
1400867001607	ligand binding site [chemical binding]; other site
1400867001608	Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139
1400867001609	hypothetical protein; Reviewed; Region: PRK09588
1400867001610	lysine transporter; Provisional; Region: PRK10836
1400867001611	lysine transporter; Provisional; Region: PRK10836
1400867001612	16S ribosomal RNA m2G1207 methyltransferase; Provisional; Region: rsmC; PRK09489
1400867001613	Methyltransferase small domain N-terminal; Region: MTS_N; pfam08468
1400867001614	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1400867001615	S-adenosylmethionine binding site [chemical binding]; other site
1400867001616	Xanthine/uracil permeases [Nucleotide transport and metabolism]; Region: UraA; COG2233
1400867001617	Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217
1400867001618	Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891
1400867001619	G1 box; other site
1400867001620	putative GEF interaction site [polypeptide binding]; other site
1400867001621	GTP/Mg2+ binding site [chemical binding]; other site
1400867001622	Switch I region; other site
1400867001623	G2 box; other site
1400867001624	G3 box; other site
1400867001625	Switch II region; other site
1400867001626	G4 box; other site
1400867001627	G5 box; other site
1400867001628	BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu.  BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691
1400867001629	BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants.  BipA is a highly...; Region: BipA_TypA_C; cd03710
1400867001630	large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13952
1400867001631	large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567
1400867001632	GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661
1400867001633	putative active site pocket [active]
1400867001634	dimerization interface [polypeptide binding]; other site
1400867001635	putative catalytic residue [active]
1400867001636	PPIC-type PPIASE domain; Region: Rotamase_2; cl08278
1400867001637	formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103
1400867001638	N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966
1400867001639	DNA binding site [nucleotide binding]
1400867001640	catalytic residue [active]
1400867001641	H2TH interface [polypeptide binding]; other site
1400867001642	putative catalytic residues [active]
1400867001643	turnover-facilitating residue; other site
1400867001644	intercalation triad [nucleotide binding]; other site
1400867001645	8OG recognition residue [nucleotide binding]; other site
1400867001646	putative reading head residues; other site
1400867001647	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
1400867001648	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
1400867001649	Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540
1400867001650	active site
1400867001651	DNA binding site [nucleotide binding]
1400867001652	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
1400867001653	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
1400867001654	N-terminal plug; other site
1400867001655	ligand-binding site [chemical binding]; other site
1400867001656	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
1400867001657	Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis.  Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932
1400867001658	active site
1400867001659	FMN binding site [chemical binding]; other site
1400867001660	substrate binding site [chemical binding]; other site
1400867001661	homotetramer interface [polypeptide binding]; other site
1400867001662	catalytic residue [active]
1400867001663	Predicted permeases [General function prediction only]; Region: COG0679
1400867001664	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
1400867001665	Sel1-like repeats; Region: SEL1; smart00671
1400867001666	protein disulfide isomerase II DsbC; Provisional; Region: PRK10877
1400867001667	DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020
1400867001668	dimerization domain [polypeptide binding]; other site
1400867001669	dimer interface [polypeptide binding]; other site
1400867001670	catalytic residues [active]
1400867001671	Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354
1400867001672	folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317
1400867001673	Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_2; cd08895
1400867001674	putative hydrophobic ligand binding site [chemical binding]; other site
1400867001675	Uncharacterized conserved protein [Function unknown]; Region: COG3189
1400867001676	Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824
1400867001677	PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274
1400867001678	PhnA protein; Region: PhnA; pfam03831
1400867001679	Uncharacterized conserved protein [Function unknown]; Region: COG3422
1400867001680	Domain of unknown function (DUF1508); Region: DUF1508; pfam07411
1400867001681	prolyl-tRNA synthetase; Provisional; Region: PRK09194
1400867001682	Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779
1400867001683	dimer interface [polypeptide binding]; other site
1400867001684	motif 1; other site
1400867001685	active site
1400867001686	motif 2; other site
1400867001687	INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334
1400867001688	putative deacylase active site [active]
1400867001689	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
1400867001690	active site
1400867001691	motif 3; other site
1400867001692	ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861
1400867001693	anticodon binding site; other site
1400867001694	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
1400867001695	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
1400867001696	HlyD family secretion protein; Region: HlyD_3; pfam13437
1400867001697	Response regulator receiver domain; Region: Response_reg; pfam00072
1400867001698	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1400867001699	active site
1400867001700	phosphorylation site [posttranslational modification]
1400867001701	intermolecular recognition site; other site
1400867001702	dimerization interface [polypeptide binding]; other site
1400867001703	Response regulator receiver domain; Region: Response_reg; pfam00072
1400867001704	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1400867001705	active site
1400867001706	phosphorylation site [posttranslational modification]
1400867001707	intermolecular recognition site; other site
1400867001708	dimerization interface [polypeptide binding]; other site
1400867001709	Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835
1400867001710	Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675
1400867001711	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
1400867001712	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1400867001713	dimer interface [polypeptide binding]; other site
1400867001714	putative CheW interface [polypeptide binding]; other site
1400867001715	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
1400867001716	putative binding surface; other site
1400867001717	active site
1400867001718	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
1400867001719	putative binding surface; other site
1400867001720	active site
1400867001721	Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643
1400867001722	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
1400867001723	putative binding surface; other site
1400867001724	active site
1400867001725	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
1400867001726	putative binding surface; other site
1400867001727	active site
1400867001728	Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895
1400867001729	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
1400867001730	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1400867001731	ATP binding site [chemical binding]; other site
1400867001732	Mg2+ binding site [ion binding]; other site
1400867001733	G-X-G motif; other site
1400867001734	CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731
1400867001735	Response regulator receiver domain; Region: Response_reg; pfam00072
1400867001736	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1400867001737	active site
1400867001738	phosphorylation site [posttranslational modification]
1400867001739	intermolecular recognition site; other site
1400867001740	dimerization interface [polypeptide binding]; other site
1400867001741	succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009
1400867001742	M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891
1400867001743	metal binding site [ion binding]; metal-binding site
1400867001744	dimer interface [polypeptide binding]; other site
1400867001745	Predicted small secreted protein [Function unknown]; Region: COG5510
1400867001746	Domain of unknown function (DUF1853); Region: DUF1853; cl01545
1400867001747	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2832
1400867001748	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
1400867001749	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
1400867001750	Uncharacterized conserved protein [Function unknown]; Region: COG1434
1400867001751	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
1400867001752	putative active site [active]
1400867001753	Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182
1400867001754	PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172
1400867001755	PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703
1400867001756	Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; Region: CysJ; COG0369
1400867001757	Flavodoxin; Region: Flavodoxin_1; pfam00258
1400867001758	Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR_like1; cd06200
1400867001759	FAD binding pocket [chemical binding]; other site
1400867001760	FAD binding motif [chemical binding]; other site
1400867001761	catalytic residues [active]
1400867001762	NAD binding pocket [chemical binding]; other site
1400867001763	phosphate binding motif [ion binding]; other site
1400867001764	beta-alpha-beta structure motif; other site
1400867001765	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
1400867001766	YcxB-like protein; Region: YcxB; pfam14317
1400867001767	TIGR01666 family membrane protein; Region: YCCS
1400867001768	FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805
1400867001769	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
1400867001770	bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102
1400867001771	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1400867001772	putative substrate translocation pore; other site
1400867001773	Nitroreductase family. Members of this family utilize FMN as a cofactor and catalyze reduction of a variety of nitroaromatic compounds, including nitrofurans, nitrobenzens, nitrophenol, nitrobenzoate and quinones by using either NADH or NADPH as a source...; Region: Nitroreductase; cd02136
1400867001774	putative FMN binding site [chemical binding]; other site
1400867001775	Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115
1400867001776	Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548
1400867001777	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752
1400867001778	Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205
1400867001779	active site
1400867001780	nucleophile elbow; other site
1400867001781	threonine dehydratase; Provisional; Region: PRK07334
1400867001782	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
1400867001783	tetramer interface [polypeptide binding]; other site
1400867001784	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1400867001785	catalytic residue [active]
1400867001786	C-terminal ACT domain of biodegradative (catabolic) threonine dehydratase II (ThrD-II) and other related ACT domains; Region: ACT_ThrD-II-like; cd04886
1400867001787	microcin B17 transporter; Reviewed; Region: PRK11098
1400867001788	Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590
1400867001789	Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662
1400867001790	active site
1400867001791	Zn binding site [ion binding]; other site
1400867001792	Protein of unknown function (DUF1176); Region: DUF1176; pfam06674
1400867001793	intracellular protease, PfpI family; Region: PfpI; TIGR01382
1400867001794	Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_1; cd03169
1400867001795	conserved cys residue [active]
1400867001796	aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477
1400867001797	GatB/GatE catalytic domain; Region: GatB_N; pfam02934
1400867001798	GatB domain; Region: GatB_Yqey; smart00845
1400867001799	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
1400867001800	aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012
1400867001801	aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034
1400867001802	rod shape-determining protein MreB; Provisional; Region: PRK13927
1400867001803	MreB and similar proteins; Region: MreB_like; cd10225
1400867001804	nucleotide binding site [chemical binding]; other site
1400867001805	Mg binding site [ion binding]; other site
1400867001806	putative protofilament interaction site [polypeptide binding]; other site
1400867001807	RodZ interaction site [polypeptide binding]; other site
1400867001808	rod shape-determining protein MreC; Provisional; Region: PRK13922
1400867001809	rod shape-determining protein MreC; Region: MreC; pfam04085
1400867001810	rod shape-determining protein MreD; Region: shape_MreD; TIGR03426
1400867001811	Maf-like protein; Region: Maf; pfam02545
1400867001812	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
1400867001813	active site
1400867001814	dimer interface [polypeptide binding]; other site
1400867001815	ribonuclease G; Provisional; Region: PRK11712
1400867001816	S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453
1400867001817	homodimer interface [polypeptide binding]; other site
1400867001818	oligonucleotide binding site [chemical binding]; other site
1400867001819	acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946
1400867001820	Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007
1400867001821	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
1400867001822	Active Sites [active]
1400867001823	phosphoserine phosphatase; Provisional; Region: thrH; PRK13582
1400867001824	Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560
1400867001825	Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; cl17479
1400867001826	Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525
1400867001827	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
1400867001828	Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625
1400867001829	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1400867001830	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1400867001831	This CD includes the dihydrorhizobitoxine fatty acid desaturase (RtxC) characterized in Bradyrhizobium japonicum USDA110, and other related proteins. Dihydrorhizobitoxine desaturase is reported to be involved in the final step of rhizobitoxine...; Region: Rhizobitoxine-FADS-like; cd03510
1400867001832	putative di-iron ligands [ion binding]; other site
1400867001833	This CD includes the dihydrorhizobitoxine fatty acid desaturase (RtxC) characterized in Bradyrhizobium japonicum USDA110, and other related proteins. Dihydrorhizobitoxine desaturase is reported to be involved in the final step of rhizobitoxine...; Region: Rhizobitoxine-FADS-like; cd03510
1400867001834	Mrr N-terminal domain; Region: Mrr_N; pfam14338
1400867001835	PaaX-like protein C-terminal domain; Region: PaaX_C; pfam08223
1400867001836	undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281
1400867001837	AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719
1400867001838	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1400867001839	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1400867001840	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1400867001841	putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824
1400867001842	PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276
1400867001843	NAD(P) binding site [chemical binding]; other site
1400867001844	chaperone protein HchA; Provisional; Region: PRK04155
1400867001845	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
1400867001846	conserved cys residue [active]
1400867001847	Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113
1400867001848	probable AcnD-accessory protein PrpF; Region: prpF; TIGR02334
1400867001849	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
1400867001850	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
1400867001851	substrate binding pocket [chemical binding]; other site
1400867001852	chain length determination region; other site
1400867001853	substrate-Mg2+ binding site; other site
1400867001854	catalytic residues [active]
1400867001855	aspartate-rich region 1; other site
1400867001856	active site lid residues [active]
1400867001857	aspartate-rich region 2; other site
1400867001858	Protein of unknown function (DUF419); Region: DUF419; cl15265
1400867001859	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
1400867001860	Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403
1400867001861	Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585
1400867001862	hypothetical protein; Provisional; Region: PRK10279
1400867001863	Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205
1400867001864	nucleophile elbow; other site
1400867001865	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
1400867001866	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown ABO13168; Region: LPLAT_ABO13168-like; cd07988
1400867001867	putative acyl-acceptor binding pocket; other site
1400867001868	siderophore transporter, RhtX/FptX family; Region: sider_RhtX_FptX; TIGR02718
1400867001869	muropeptide transporter; Validated; Region: ampG; cl17669
1400867001870	putative metal dependent hydrolase; Provisional; Region: PRK11598
1400867001871	Domain of unknown function (DUF1705); Region: DUF1705; pfam08019
1400867001872	Sulfatase; Region: Sulfatase; pfam00884
1400867001873	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1400867001874	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1400867001875	active site
1400867001876	phosphorylation site [posttranslational modification]
1400867001877	intermolecular recognition site; other site
1400867001878	dimerization interface [polypeptide binding]; other site
1400867001879	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1400867001880	DNA binding site [nucleotide binding]
1400867001881	sensor protein QseC; Provisional; Region: PRK10337
1400867001882	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1400867001883	dimer interface [polypeptide binding]; other site
1400867001884	phosphorylation site [posttranslational modification]
1400867001885	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1400867001886	ATP binding site [chemical binding]; other site
1400867001887	Mg2+ binding site [ion binding]; other site
1400867001888	G-X-G motif; other site
1400867001889	PAP2_like_6 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which mainly contains bacterial proteins, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_6; cd03396
1400867001890	active site
1400867001891	Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004
1400867001892	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1400867001893	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1400867001894	putative DNA binding site [nucleotide binding]; other site
1400867001895	putative Zn2+ binding site [ion binding]; other site
1400867001896	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
1400867001897	dimerization interface [polypeptide binding]; other site
1400867001898	Predicted permeases [General function prediction only]; Region: COG0679
1400867001899	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1400867001900	S-adenosylmethionine binding site [chemical binding]; other site
1400867001901	valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729
1400867001902	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
1400867001903	HIGH motif; other site
1400867001904	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
1400867001905	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
1400867001906	active site
1400867001907	KMSKS motif; other site
1400867001908	Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962
1400867001909	tRNA binding surface [nucleotide binding]; other site
1400867001910	anticodon binding site; other site
1400867001911	Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458
1400867001912	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1400867001913	short chain dehydrogenase; Provisional; Region: PRK06181
1400867001914	NAD(P) binding site [chemical binding]; other site
1400867001915	active site
1400867001916	SnoaL-like domain; Region: SnoaL_4; pfam13577
1400867001917	Uncharacterized conserved protein [Function unknown]; Region: COG0393
1400867001918	Putative heavy-metal-binding; Region: YbjQ_1; cl00426
1400867001919	Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538
1400867001920	The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915
1400867001921	Protein export membrane protein; Region: SecD_SecF; cl14618
1400867001922	multidrug efflux system transporter AcrA; Provisional; Region: PRK15030
1400867001923	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
1400867001924	HlyD family secretion protein; Region: HlyD_3; pfam13437
1400867001925	PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392
1400867001926	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
1400867001927	active site
1400867001928	Site-specific recombinase; Region: SpecificRecomb; pfam10136
1400867001929	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
1400867001930	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
1400867001931	substrate binding pocket [chemical binding]; other site
1400867001932	chain length determination region; other site
1400867001933	substrate-Mg2+ binding site; other site
1400867001934	catalytic residues [active]
1400867001935	aspartate-rich region 1; other site
1400867001936	active site lid residues [active]
1400867001937	aspartate-rich region 2; other site
1400867001938	50S ribosomal protein L21; Validated; Region: rplU; PRK05573
1400867001939	50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278
1400867001940	50S ribosomal protein L27; Validated; Region: rpmA; PRK05435
1400867001941	lipoprotein chaperone; Reviewed; Region: lolA; PRK00031
1400867001942	Outer membrane lipoprotein carrier protein LolA; Region: LolA; pfam03548
1400867001943	Protein of unknown function (DUF3298); Region: DUF3298; pfam11738
1400867001944	seryl-tRNA synthetase; Provisional; Region: PRK05431
1400867001945	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
1400867001946	Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770
1400867001947	dimer interface [polypeptide binding]; other site
1400867001948	active site
1400867001949	motif 1; other site
1400867001950	motif 2; other site
1400867001951	motif 3; other site
1400867001952	siroheme synthase; Provisional; Region: cysG; PRK10637
1400867001953	Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241
1400867001954	Sirohaem synthase dimerisation region; Region: CysG_dimeriser; pfam10414
1400867001955	Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642
1400867001956	active site
1400867001957	SAM binding site [chemical binding]; other site
1400867001958	homodimer interface [polypeptide binding]; other site
1400867001959	Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219
1400867001960	Predicted transcriptional regulators [Transcription]; Region: COG1733
1400867001961	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1400867001962	dimerization interface [polypeptide binding]; other site
1400867001963	putative DNA binding site [nucleotide binding]; other site
1400867001964	putative Zn2+ binding site [ion binding]; other site
1400867001965	Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655
1400867001966	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
1400867001967	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
1400867001968	Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454
1400867001969	Iron-containing alcohol dehydrogenases-like; Region: Fe-ADH5; cd08189
1400867001970	putative active site [active]
1400867001971	metal binding site [ion binding]; metal-binding site
1400867001972	lipoate-protein ligase B; Provisional; Region: PRK14342
1400867001973	Protein of unknown function (DUF493); Region: DUF493; pfam04359
1400867001974	Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979
1400867001975	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
1400867001976	Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546
1400867001977	RNA polymerase sigma factor RpoD, C-terminal domain; Region: RpoD_Cterm; TIGR02393
1400867001978	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1400867001979	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
1400867001980	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1400867001981	DNA binding residues [nucleotide binding]
1400867001982	Uncharacterized protein family (UPF0149); Region: UPF0149; pfam03695
1400867001983	Predicted sulfurtransferase [General function prediction only]; Region: COG1054
1400867001984	Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518
1400867001985	active site residue [active]
1400867001986	Protein of unknown function (DUF1289); Region: DUF1289; pfam06945
1400867001987	Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114
1400867001988	Citrate synthase [Energy production and conversion]; Region: GltA; COG0372
1400867001989	dimer interface [polypeptide binding]; other site
1400867001990	active site
1400867001991	citrylCoA binding site [chemical binding]; other site
1400867001992	NADH binding [chemical binding]; other site
1400867001993	cationic pore residues; other site
1400867001994	oxalacetate/citrate binding site [chemical binding]; other site
1400867001995	coenzyme A binding site [chemical binding]; other site
1400867001996	catalytic triad [active]
1400867001997	Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499
1400867001998	proximal quinone binding site [chemical binding]; other site
1400867001999	SdhD (CybS) interface [polypeptide binding]; other site
1400867002000	proximal heme binding site [chemical binding]; other site
1400867002001	Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. E. coli SQR, a member of this subfamily, reduces the...; Region: SQR_TypeC_SdhD; cd03494
1400867002002	SdhC subunit interface [polypeptide binding]; other site
1400867002003	proximal heme binding site [chemical binding]; other site
1400867002004	cardiolipin binding site; other site
1400867002005	Iron-sulfur protein interface; other site
1400867002006	proximal quinone binding site [chemical binding]; other site
1400867002007	succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07057
1400867002008	L-aspartate oxidase; Provisional; Region: PRK06175
1400867002009	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
1400867002010	succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950
1400867002011	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085
1400867002012	2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404
1400867002013	Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016
1400867002014	TPP-binding site [chemical binding]; other site
1400867002015	Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779
1400867002016	dihydrolipoamide succinyltransferase; Validated; Region: PRK05704
1400867002017	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
1400867002018	E3 interaction surface; other site
1400867002019	lipoyl attachment site [posttranslational modification]; other site
1400867002020	e3 binding domain; Region: E3_binding; pfam02817
1400867002021	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
1400867002022	dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06467
1400867002023	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1400867002024	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1400867002025	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
1400867002026	succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696
1400867002027	ATP-grasp domain; Region: ATP-grasp_2; pfam08442
1400867002028	CoA-ligase; Region: Ligase_CoA; pfam00549
1400867002029	succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678
1400867002030	CoA binding domain; Region: CoA_binding; smart00881
1400867002031	CoA-ligase; Region: Ligase_CoA; pfam00549
1400867002032	tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282
1400867002033	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
1400867002034	active site
1400867002035	HIGH motif; other site
1400867002036	dimer interface [polypeptide binding]; other site
1400867002037	KMSKS motif; other site
1400867002038	Protein of unknown function (DUF808); Region: DUF808; pfam05661
1400867002039	Predicted metalloprotease [General function prediction only]; Region: COG2321
1400867002040	Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228
1400867002041	NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025
1400867002042	Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753
1400867002043	Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753
1400867002044	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
1400867002045	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
1400867002046	type I secretion C-terminal target domain (VC_A0849 subclass); Region: T1SS_VCA0849; TIGR03661
1400867002047	LanC-like proteins. LanC is the cyclase enzyme of the lanthionine synthetase. Lanthionine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as a precursor peptide and then post-translationally modified to contain...; Region: LanC_like; cl04955
1400867002048	CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381
1400867002049	putative active site [active]
1400867002050	putative metal binding site [ion binding]; other site
1400867002051	Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854
1400867002052	Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064
1400867002053	active site
1400867002054	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
1400867002055	DNA binding site [nucleotide binding]
1400867002056	active site
1400867002057	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
1400867002058	Ligand Binding Site [chemical binding]; other site
1400867002059	Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110
1400867002060	Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349
1400867002061	trimer interface [polypeptide binding]; other site
1400867002062	active site
1400867002063	substrate binding site [chemical binding]; other site
1400867002064	CoA binding site [chemical binding]; other site
1400867002065	transcription elongation factor GreA; Reviewed; Region: greA; PRK00226
1400867002066	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
1400867002067	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
1400867002068	carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294
1400867002069	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
1400867002070	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
1400867002071	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
1400867002072	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
1400867002073	ATP-grasp domain; Region: ATP-grasp_4; cl17255
1400867002074	Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424
1400867002075	IMP binding site; other site
1400867002076	dimer interface [polypeptide binding]; other site
1400867002077	interdomain contacts; other site
1400867002078	partial ornithine binding site; other site
1400867002079	carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564
1400867002080	Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097
1400867002081	Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744
1400867002082	catalytic site [active]
1400867002083	subunit interface [polypeptide binding]; other site
1400867002084	Domon-like domain of UDP-N-acetylenolpyruvoylglucosamine reductase; Region: DOMON_murB_like; cd09627
1400867002085	putative heme binding site [chemical binding]; other site
1400867002086	Escherichia coli YhbY is associated with pre-50S ribosomal subunits, which implies a function in ribosome assembly; Region: CRS1_YhbY; smart01103
1400867002087	FtsJ-like methyltransferase; Region: FtsJ; cl17430
1400867002088	23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293
1400867002089	FtsH Extracellular; Region: FtsH_ext; pfam06480
1400867002090	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
1400867002091	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1400867002092	Walker A motif; other site
1400867002093	ATP binding site [chemical binding]; other site
1400867002094	Walker B motif; other site
1400867002095	arginine finger; other site
1400867002096	Peptidase family M41; Region: Peptidase_M41; pfam01434
1400867002097	DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
1400867002098	dihydropteroate synthase; Region: DHPS; TIGR01496
1400867002099	substrate binding pocket [chemical binding]; other site
1400867002100	dimer interface [polypeptide binding]; other site
1400867002101	inhibitor binding site; inhibition site
1400867002102	PhoD-like phosphatase; Region: PhoD; pfam09423
1400867002103	Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389
1400867002104	putative active site [active]
1400867002105	putative metal binding site [ion binding]; other site
1400867002106	Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389
1400867002107	bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14192
1400867002108	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
1400867002109	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
1400867002110	homodimer interface [polypeptide binding]; other site
1400867002111	NADP binding site [chemical binding]; other site
1400867002112	substrate binding site [chemical binding]; other site
1400867002113	Predicted methyltransferase [General function prediction only]; Region: COG3897
1400867002114	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1400867002115	S-adenosylmethionine binding site [chemical binding]; other site
1400867002116	alpha-ketoglutarate transporter; Provisional; Region: PRK10406
1400867002117	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1400867002118	putative substrate translocation pore; other site
1400867002119	glycerol kinase; Provisional; Region: glpK; PRK00047
1400867002120	Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786
1400867002121	N- and C-terminal domain interface [polypeptide binding]; other site
1400867002122	active site
1400867002123	MgATP binding site [chemical binding]; other site
1400867002124	catalytic site [active]
1400867002125	metal binding site [ion binding]; metal-binding site
1400867002126	glycerol binding site [chemical binding]; other site
1400867002127	homotetramer interface [polypeptide binding]; other site
1400867002128	homodimer interface [polypeptide binding]; other site
1400867002129	FBP binding site [chemical binding]; other site
1400867002130	protein IIAGlc interface [polypeptide binding]; other site
1400867002131	glycerol-3-phosphate dehydrogenase; Reviewed; Region: glpD; PRK12266
1400867002132	Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819
1400867002133	active site
1400867002134	substrate-binding site [chemical binding]; other site
1400867002135	metal-binding site [ion binding]
1400867002136	GTP binding site [chemical binding]; other site
1400867002137	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
1400867002138	Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597
1400867002139	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
1400867002140	Bacillus subtilis YydB and related proteins, metallophosphatase domain; Region: MPP_YydB; cd07400
1400867002141	putative active site [active]
1400867002142	putative metal binding site [ion binding]; other site
1400867002143	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
1400867002144	active site
1400867002145	metal binding site [ion binding]; metal-binding site
1400867002146	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
1400867002147	oligomerisation interface [polypeptide binding]; other site
1400867002148	mobile loop; other site
1400867002149	roof hairpin; other site
1400867002150	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
1400867002151	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
1400867002152	ring oligomerisation interface [polypeptide binding]; other site
1400867002153	ATP/Mg binding site [chemical binding]; other site
1400867002154	stacking interactions; other site
1400867002155	hinge regions; other site
1400867002156	Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818
1400867002157	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
1400867002158	glycerophosphodiester phosphodiesterase; Provisional; Region: glpQ; PRK11143
1400867002159	Glycerophosphodiester phosphodiesterase domain of Streptomycin coelicolor (GlpQ1) and similar proteins; Region: GDPD_ScGlpQ1_like; cd08602
1400867002160	putative active site [active]
1400867002161	catalytic site [active]
1400867002162	putative metal binding site [ion binding]; other site
1400867002163	The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915
1400867002164	Protein export membrane protein; Region: SecD_SecF; cl14618
1400867002165	Domain of unknown function (DUF4112); Region: DUF4112; pfam13430
1400867002166	heat shock protein HtpX; Provisional; Region: PRK05457
1400867002167	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
1400867002168	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
1400867002169	N-acetyl-D-glucosamine binding site [chemical binding]; other site
1400867002170	catalytic residue [active]
1400867002171	tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696
1400867002172	This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily  includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which  binds to Adenosine group.  This subfamily; Region: Alpha_ANH_like_II; cd01993
1400867002173	Ligand Binding Site [chemical binding]; other site
1400867002174	SCP-2 sterol transfer family; Region: SCP2; pfam02036
1400867002175	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
1400867002176	N-acetyl-D-glucosamine binding site [chemical binding]; other site
1400867002177	catalytic residue [active]
1400867002178	transcription elongation factor GreB; Reviewed; Region: greB; PRK01885
1400867002179	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
1400867002180	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
1400867002181	Calcium/calmodulin dependent protein kinase II Association; Region: CaMKII_AD; cl17504
1400867002182	The adenylation (A) domain of siderophore-synthesizing nonribosomal peptide synthetases (NRPS); Region: A_NRPS_SidN3_like; cd05918
1400867002183	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
1400867002184	acyl-activating enzyme (AAE) consensus motif; other site
1400867002185	AMP binding site [chemical binding]; other site
1400867002186	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1400867002187	non-ribosomal peptide synthetase terminal domain of unknown function; Region: NRPS_term_dom; TIGR02353
1400867002188	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
1400867002189	putative trimer interface [polypeptide binding]; other site
1400867002190	putative CoA binding site [chemical binding]; other site
1400867002191	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
1400867002192	putative CoA binding site [chemical binding]; other site
1400867002193	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
1400867002194	putative trimer interface [polypeptide binding]; other site
1400867002195	putative CoA binding site [chemical binding]; other site
1400867002196	Predicted ATPases [General function prediction only]; Region: COG1106
1400867002197	RloB-like protein; Region: RloB; pfam13707
1400867002198	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1400867002199	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1400867002200	Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687
1400867002201	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1400867002202	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1400867002203	Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137
1400867002204	dimer interface [polypeptide binding]; other site
1400867002205	FMN binding site [chemical binding]; other site
1400867002206	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
1400867002207	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1400867002208	NAD(P) binding site [chemical binding]; other site
1400867002209	active site
1400867002210	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1400867002211	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1400867002212	Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929
1400867002213	oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701
1400867002214	The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767
1400867002215	putative molybdopterin cofactor binding site [chemical binding]; other site
1400867002216	The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787
1400867002217	putative molybdopterin cofactor binding site; other site
1400867002218	formate dehydrogenase accessory protein; Reviewed; Region: PRK00724
1400867002219	Protein of unknown function (DUF1232); Region: DUF1232; cl01318
1400867002220	erythronate-4-phosphate dehydrogenase; Validated; Region: PRK00257
1400867002221	D-Erythronate-4-Phosphate Dehydrogenase NAD-binding and catalytic domains; Region: ErythrP_dh; cd12158
1400867002222	ligand binding site [chemical binding]; other site
1400867002223	NAD binding site [chemical binding]; other site
1400867002224	catalytic site [active]
1400867002225	homodimer interface [polypeptide binding]; other site
1400867002226	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
1400867002227	EF-P lysine aminoacylase GenX; Region: genX; TIGR00462
1400867002228	motif 1; other site
1400867002229	dimer interface [polypeptide binding]; other site
1400867002230	active site
1400867002231	motif 2; other site
1400867002232	motif 3; other site
1400867002233	Tim44 is an essential component of the machinery that mediates the translocation of nuclear-encoded proteins across the mitochondrial inner membrane; Region: Tim44; smart00978
1400867002234	DNA repair protein RadA; Provisional; Region: PRK11823
1400867002235	Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121
1400867002236	Walker A motif/ATP binding site; other site
1400867002237	ATP binding site [chemical binding]; other site
1400867002238	Walker B motif; other site
1400867002239	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
1400867002240	D-alanine/D-serine/glycine permease; Provisional; Region: PRK11049
1400867002241	diaminopimelate decarboxylase; Region: lysA; TIGR01048
1400867002242	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828
1400867002243	active site
1400867002244	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
1400867002245	substrate binding site [chemical binding]; other site
1400867002246	catalytic residues [active]
1400867002247	dimer interface [polypeptide binding]; other site
1400867002248	diaminopimelate epimerase; Provisional; Region: dapF; PRK00450
1400867002249	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
1400867002250	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
1400867002251	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
1400867002252	Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303
1400867002253	catalytic site [active]
1400867002254	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
1400867002255	site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236
1400867002256	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
1400867002257	active site
1400867002258	DNA binding site [nucleotide binding]
1400867002259	Int/Topo IB signature motif; other site
1400867002260	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714
1400867002261	Ligand binding site [chemical binding]; other site
1400867002262	Electron transfer flavoprotein domain; Region: ETF; pfam01012
1400867002263	electron transfer flavoprotein subunit alpha; Provisional; Region: PLN00022
1400867002264	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715
1400867002265	Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766
1400867002266	DNA gyrase subunit A; Validated; Region: PRK05560
1400867002267	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
1400867002268	CAP-like domain; other site
1400867002269	active site
1400867002270	primary dimer interface [polypeptide binding]; other site
1400867002271	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1400867002272	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1400867002273	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1400867002274	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1400867002275	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1400867002276	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1400867002277	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364
1400867002278	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364
1400867002279	GtrA-like protein; Region: GtrA; pfam04138
1400867002280	undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714
1400867002281	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
1400867002282	Ligand binding site; other site
1400867002283	Putative Catalytic site; other site
1400867002284	DXD motif; other site
1400867002285	uncharacterized YdjC-like family proteins from bacteria; Region: YdjC_like_3; cd10807
1400867002286	putative active site [active]
1400867002287	YdjC motif; other site
1400867002288	Mg binding site [ion binding]; other site
1400867002289	putative homodimer interface [polypeptide binding]; other site
1400867002290	ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698
1400867002291	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
1400867002292	ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698
1400867002293	Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566
1400867002294	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
1400867002295	HlyD family secretion protein; Region: HlyD_3; pfam13437
1400867002296	Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538
1400867002297	Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT).  PSAT is active as...; Region: PSAT_like; cd00611
1400867002298	homodimer interface [polypeptide binding]; other site
1400867002299	substrate-cofactor binding pocket; other site
1400867002300	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1400867002301	catalytic residue [active]
1400867002302	Uncharacterized BCR, YaiI/YqxD family COG1671; Region: DUF188; pfam02639
1400867002303	putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272
1400867002304	EamA-like transporter family; Region: EamA; pfam00892
1400867002305	lipoprotein releasing system, transmembrane protein, LolC/E family; Region: lolCE; TIGR02212
1400867002306	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
1400867002307	FtsX-like permease family; Region: FtsX; pfam02687
1400867002308	lipoprotein releasing system, ATP-binding protein; Region: LolD_lipo_ex; TIGR02211
1400867002309	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
1400867002310	Walker A/P-loop; other site
1400867002311	ATP binding site [chemical binding]; other site
1400867002312	Q-loop/lid; other site
1400867002313	ABC transporter signature motif; other site
1400867002314	Walker B; other site
1400867002315	D-loop; other site
1400867002316	H-loop/switch region; other site
1400867002317	Domain of unknown function (DUF4131); Region: DUF4131; pfam13567
1400867002318	Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658
1400867002319	Competence protein; Region: Competence; pfam03772
1400867002320	Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333
1400867002321	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
1400867002322	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
1400867002323	putative acyl-acceptor binding pocket; other site
1400867002324	Periplasmic serine proteases (ClpP class) [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: SppA; COG0616
1400867002325	Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023
1400867002326	tandem repeat interface [polypeptide binding]; other site
1400867002327	oligomer interface [polypeptide binding]; other site
1400867002328	active site residues [active]
1400867002329	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
1400867002330	phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647
1400867002331	Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645
1400867002332	active site
1400867002333	substrate binding site [chemical binding]; other site
1400867002334	cosubstrate binding site; other site
1400867002335	catalytic site [active]
1400867002336	phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385
1400867002337	PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196
1400867002338	dimerization interface [polypeptide binding]; other site
1400867002339	putative ATP binding site [chemical binding]; other site
1400867002340	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
1400867002341	Domain of unknown function DUF20; Region: UPF0118; pfam01594
1400867002342	ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593
1400867002343	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1400867002344	Walker A motif; other site
1400867002345	ATP binding site [chemical binding]; other site
1400867002346	Walker B motif; other site
1400867002347	arginine finger; other site
1400867002348	Acinetobacter rhombotarget A; Region: GlyGly_RbtA; TIGR04212
1400867002349	CSLREA domain; Region: CSLREA_Nterm; TIGR04214
1400867002350	CSLREA domain; Region: CSLREA_Nterm; TIGR04214
1400867002351	Protein of unknown function (DUF3106); Region: DUF3106; pfam11304
1400867002352	RNA polymerase factor sigma-70; Validated; Region: PRK09047
1400867002353	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1400867002354	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1400867002355	DNA binding residues [nucleotide binding]
1400867002356	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
1400867002357	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
1400867002358	fructose-1,6-bisphosphatase family protein; Region: PLN02628
1400867002359	Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate  into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354
1400867002360	AMP binding site [chemical binding]; other site
1400867002361	metal binding site [ion binding]; metal-binding site
1400867002362	active site
1400867002363	putative outer membrane lipoprotein; Provisional; Region: PRK09967
1400867002364	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
1400867002365	ligand binding site [chemical binding]; other site
1400867002366	translocation protein TolB; Provisional; Region: tolB; PRK04922
1400867002367	TolB amino-terminal domain; Region: TolB_N; pfam04052
1400867002368	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
1400867002369	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
1400867002370	TolA protein; Region: tolA_full; TIGR02794
1400867002371	TonB C terminal; Region: TonB_2; pfam13103
1400867002372	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
1400867002373	TolR protein; Region: tolR; TIGR02801
1400867002374	TolQ protein; Region: tolQ; TIGR02796
1400867002375	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
1400867002376	active site
1400867002377	M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like2; cd05667
1400867002378	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
1400867002379	metal binding site [ion binding]; metal-binding site
1400867002380	putative dimer interface [polypeptide binding]; other site
1400867002381	Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080
1400867002382	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078
1400867002383	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1400867002384	Walker A motif; other site
1400867002385	ATP binding site [chemical binding]; other site
1400867002386	Walker B motif; other site
1400867002387	arginine finger; other site
1400867002388	Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491
1400867002389	Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116
1400867002390	RuvA N terminal domain; Region: RuvA_N; pfam01330
1400867002391	RuvA, C-terminal domain; Region: RuvA_C; pfam07499
1400867002392	deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01096
1400867002393	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
1400867002394	Zn2+ binding site [ion binding]; other site
1400867002395	Mg2+ binding site [ion binding]; other site
1400867002396	phosphoribosylformylglycinamidine synthase; Provisional; Region: PRK05297
1400867002397	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203
1400867002398	dimerization interface [polypeptide binding]; other site
1400867002399	ATP binding site [chemical binding]; other site
1400867002400	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204
1400867002401	dimerization interface [polypeptide binding]; other site
1400867002402	ATP binding site [chemical binding]; other site
1400867002403	Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740
1400867002404	putative active site [active]
1400867002405	catalytic triad [active]
1400867002406	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1400867002407	putative substrate translocation pore; other site
1400867002408	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323
1400867002409	enoyl-CoA hydratase; Provisional; Region: PRK06688
1400867002410	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
1400867002411	substrate binding site [chemical binding]; other site
1400867002412	oxyanion hole (OAH) forming residues; other site
1400867002413	trimer interface [polypeptide binding]; other site
1400867002414	nicotinamide-nucleotide adenylyltransferase; Provisional; Region: PRK13793
1400867002415	active site
1400867002416	nucleotide binding site [chemical binding]; other site
1400867002417	HIGH motif; other site
1400867002418	KMSKS motif; other site
1400867002419	Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340
1400867002420	SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379
1400867002421	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
1400867002422	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
1400867002423	catalytic triad [active]
1400867002424	Predicted ATPases of PP-loop superfamily [General function prediction only]; Region: COG2102
1400867002425	This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily  includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which  binds to Adenosine group.  This subfamily; Region: Alpha_ANH_like_IV; cd01994
1400867002426	Ligand Binding Site [chemical binding]; other site
1400867002427	ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995
1400867002428	Ligand Binding Site [chemical binding]; other site
1400867002429	putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE, gammaproteobacterial type; Region: rSAM_QueE_gams; TIGR04349
1400867002430	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1400867002431	FeS/SAM binding site; other site
1400867002432	2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830
1400867002433	2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350
1400867002434	active site
1400867002435	substrate binding site [chemical binding]; other site
1400867002436	trimer interface [polypeptide binding]; other site
1400867002437	CoA binding site [chemical binding]; other site
1400867002438	transcriptional regulator CysB-like protein; Reviewed; Region: PRK12683
1400867002439	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1400867002440	The C-terminal substrate domain of LysR-type transcriptional regulators CysB-like contains type 2 periplasmic binding fold; Region: PBP2_CysB_like; cd08413
1400867002441	substrate binding site [chemical binding]; other site
1400867002442	dimerization interface [polypeptide binding]; other site
1400867002443	ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118
1400867002444	ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296
1400867002445	Walker A/P-loop; other site
1400867002446	ATP binding site [chemical binding]; other site
1400867002447	Q-loop/lid; other site
1400867002448	ABC transporter signature motif; other site
1400867002449	Walker B; other site
1400867002450	D-loop; other site
1400867002451	H-loop/switch region; other site
1400867002452	TOBE-like domain; Region: TOBE_3; pfam12857
1400867002453	sulfate transport protein; Provisional; Region: cysT; CHL00187
1400867002454	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1400867002455	dimer interface [polypeptide binding]; other site
1400867002456	conserved gate region; other site
1400867002457	putative PBP binding loops; other site
1400867002458	ABC-ATPase subunit interface; other site
1400867002459	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
1400867002460	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1400867002461	dimer interface [polypeptide binding]; other site
1400867002462	conserved gate region; other site
1400867002463	putative PBP binding loops; other site
1400867002464	ABC-ATPase subunit interface; other site
1400867002465	Serine hydrolase; Region: Ser_hydrolase; pfam06821
1400867002466	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
1400867002467	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1400867002468	substrate binding pocket [chemical binding]; other site
1400867002469	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
1400867002470	membrane-bound complex binding site; other site
1400867002471	hinge residues; other site
1400867002472	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
1400867002473	ADCL_like: 4-Amino-4-deoxychorismate lyase:  is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate.  Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559
1400867002474	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1400867002475	catalytic residue [active]
1400867002476	YceG-like family; Region: YceG; pfam02618
1400867002477	proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010
1400867002478	dimerization interface [polypeptide binding]; other site
1400867002479	Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672
1400867002480	thymidylate kinase; Validated; Region: tmk; PRK00698
1400867002481	TMP-binding site; other site
1400867002482	ATP-binding site [chemical binding]; other site
1400867002483	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
1400867002484	CoenzymeA binding site [chemical binding]; other site
1400867002485	subunit interaction site [polypeptide binding]; other site
1400867002486	PHB binding site; other site
1400867002487	L-aspartate oxidase; Provisional; Region: PRK09077
1400867002488	L-aspartate oxidase; Provisional; Region: PRK06175
1400867002489	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
1400867002490	periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037
1400867002491	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
1400867002492	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
1400867002493	protein binding site [polypeptide binding]; other site
1400867002494	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
1400867002495	protein binding site [polypeptide binding]; other site
1400867002496	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
1400867002497	active site
1400867002498	GTP-binding protein LepA; Provisional; Region: PRK05433
1400867002499	LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890
1400867002500	G1 box; other site
1400867002501	putative GEF interaction site [polypeptide binding]; other site
1400867002502	GTP/Mg2+ binding site [chemical binding]; other site
1400867002503	Switch I region; other site
1400867002504	G2 box; other site
1400867002505	G3 box; other site
1400867002506	Switch II region; other site
1400867002507	G4 box; other site
1400867002508	G5 box; other site
1400867002509	lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699
1400867002510	lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane.   LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709
1400867002511	GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421
1400867002512	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
1400867002513	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
1400867002514	Catalytic site [active]
1400867002515	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
1400867002516	ribonuclease III; Reviewed; Region: rnc; PRK00102
1400867002517	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
1400867002518	dimerization interface [polypeptide binding]; other site
1400867002519	active site
1400867002520	metal binding site [ion binding]; metal-binding site
1400867002521	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048
1400867002522	dsRNA binding site [nucleotide binding]; other site
1400867002523	GTPase Era; Reviewed; Region: era; PRK00089
1400867002524	E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163
1400867002525	G1 box; other site
1400867002526	GTP/Mg2+ binding site [chemical binding]; other site
1400867002527	Switch I region; other site
1400867002528	G2 box; other site
1400867002529	Switch II region; other site
1400867002530	G3 box; other site
1400867002531	G4 box; other site
1400867002532	G5 box; other site
1400867002533	KH domain; Region: KH_2; pfam07650
1400867002534	DNA repair protein RecO; Reviewed; Region: recO; PRK00085
1400867002535	Recombination protein O N terminal; Region: RecO_N; pfam11967
1400867002536	Recombination protein O C terminal; Region: RecO_C; pfam02565
1400867002537	Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003
1400867002538	active site
1400867002539	hydrophilic channel; other site
1400867002540	dimerization interface [polypeptide binding]; other site
1400867002541	catalytic residues [active]
1400867002542	active site lid [active]
1400867002543	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1400867002544	malonic semialdehyde reductase; Provisional; Region: PRK10538
1400867002545	NAD(P) binding site [chemical binding]; other site
1400867002546	active site
1400867002547	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
1400867002548	CoenzymeA binding site [chemical binding]; other site
1400867002549	subunit interaction site [polypeptide binding]; other site
1400867002550	PHB binding site; other site
1400867002551	Uncharacterized conserved protein [Function unknown]; Region: COG3791
1400867002552	aspartate aminotransferase; Provisional; Region: PRK05764
1400867002553	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1400867002554	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1400867002555	homodimer interface [polypeptide binding]; other site
1400867002556	catalytic residue [active]
1400867002557	PAS domain; Region: PAS_9; pfam13426
1400867002558	PAS domain; Region: PAS_9; pfam13426
1400867002559	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1400867002560	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1400867002561	metal binding site [ion binding]; metal-binding site
1400867002562	active site
1400867002563	I-site; other site
1400867002564	hypothetical protein; Region: PHA00684
1400867002565	excinuclease ABC subunit B; Provisional; Region: PRK05298
1400867002566	Myosin and Kinesin motor domain. These ATPases belong to the P-loop NTPase family and provide the driving force in myosin and kinesin mediated processes; Region: Motor_domain; cl00286
1400867002567	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1400867002568	ATP-binding site [chemical binding]; other site
1400867002569	ATP binding site [chemical binding]; other site
1400867002570	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1400867002571	nucleotide binding region [chemical binding]; other site
1400867002572	ATP-binding site [chemical binding]; other site
1400867002573	Ultra-violet resistance protein B; Region: UvrB; pfam12344
1400867002574	UvrB/uvrC motif; Region: UVR; pfam02151
1400867002575	Bacterial lipocalin [Cell envelope biogenesis, outer membrane]; Region: Blc; COG3040
1400867002576	Lipocalin-like domain; Region: Lipocalin_2; pfam08212
1400867002577	Predicted permeases [General function prediction only]; Region: RarD; COG2962
1400867002578	glyceraldehyde-3-phosphate dehydrogenase; Reviewed; Region: PRK08289
1400867002579	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846
1400867002580	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
1400867002581	GTPase CgtA; Reviewed; Region: obgE; PRK12298
1400867002582	GTP1/OBG; Region: GTP1_OBG; pfam01018
1400867002583	Obg GTPase; Region: Obg; cd01898
1400867002584	G1 box; other site
1400867002585	GTP/Mg2+ binding site [chemical binding]; other site
1400867002586	Switch I region; other site
1400867002587	G2 box; other site
1400867002588	G3 box; other site
1400867002589	Switch II region; other site
1400867002590	G4 box; other site
1400867002591	G5 box; other site
1400867002592	gamma-glutamyl kinase; Provisional; Region: PRK05429
1400867002593	AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242
1400867002594	nucleotide binding site [chemical binding]; other site
1400867002595	homotetrameric interface [polypeptide binding]; other site
1400867002596	putative phosphate binding site [ion binding]; other site
1400867002597	putative allosteric binding site; other site
1400867002598	PUA domain; Region: PUA; pfam01472
1400867002599	Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560
1400867002600	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
1400867002601	Protein of unknown function (DUF1615); Region: DUF1615; pfam07759
1400867002602	putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737
1400867002603	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
1400867002604	FMN binding site [chemical binding]; other site
1400867002605	active site
1400867002606	catalytic residues [active]
1400867002607	substrate binding site [chemical binding]; other site
1400867002608	Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070
1400867002609	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
1400867002610	FMN binding site [chemical binding]; other site
1400867002611	substrate binding site [chemical binding]; other site
1400867002612	putative catalytic residue [active]
1400867002613	Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_1; cd02432
1400867002614	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1400867002615	TPR motif; other site
1400867002616	binding surface
1400867002617	UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381
1400867002618	Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase  family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786
1400867002619	active site
1400867002620	homodimer interface [polypeptide binding]; other site
1400867002621	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
1400867002622	Bacterial cellulose synthase subunit; Region: BcsB; cl15851
1400867002623	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
1400867002624	CESA_like is  the cellulose synthase superfamily; Region: CESA_like; cd06423
1400867002625	DXD motif; other site
1400867002626	Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415
1400867002627	DNA photolyase; Region: DNA_photolyase; pfam00875
1400867002628	FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095
1400867002629	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
1400867002630	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
1400867002631	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1400867002632	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
1400867002633	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768
1400867002634	Predicted protease with the C-terminal PDZ domain [General function prediction only]; Region: COG3975
1400867002635	M61 glycyl aminopeptidase; Region: Peptidase_M61; pfam05299
1400867002636	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
1400867002637	Monomeric isocitrate dehydrogenase [Energy production and conversion]; Region: Icd; COG2838
1400867002638	Monomeric isocitrate dehydrogenase; Region: IDH; cl15383
1400867002639	Pseudouridine synthase, Escherichia coli RluE; Region: PseudoU_synth_RluE; cd02566
1400867002640	pseudouridine synthase; Region: TIGR00093
1400867002641	probable active site [active]
1400867002642	isocitrate dehydrogenase; Validated; Region: PRK06451
1400867002643	isocitrate dehydrogenase; Reviewed; Region: PRK07006
1400867002644	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1400867002645	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1400867002646	putative substrate translocation pore; other site
1400867002647	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1400867002648	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1400867002649	The C-terminal substrate binding domain of LysR-type transcriptional regulators, YofA and SoxR, contains the type 2 periplasmic binding fold; Region: PBP2_YofA_SoxR_like; cd08442
1400867002650	putative dimerization interface [polypeptide binding]; other site
1400867002651	Predicted Na+/dicarboxylate symporter [General function prediction only]; Region: COG1823
1400867002652	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
1400867002653	Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384
1400867002654	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
1400867002655	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
1400867002656	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
1400867002657	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
1400867002658	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
1400867002659	Protein of unknown function (DUF3144); Region: DUF3144; pfam11342
1400867002660	Uncharacterized conserved protein [Function unknown]; Region: COG3025
1400867002661	Uncharacterized subgroup of the CYTH-like superfamily having an associated CHAD domain; Region: CYTH-like_Pase_CHAD; cd07756
1400867002662	putative active site [active]
1400867002663	putative metal binding residues [ion binding]; other site
1400867002664	signature motif; other site
1400867002665	putative triphosphate binding site [ion binding]; other site
1400867002666	The CHAD domain is an alpha-helical domain functionally associated with some members of the adenylate cyclase family; Region: CHAD; smart00880
1400867002667	Protein of unknown function (DUF962); Region: DUF962; pfam06127
1400867002668	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
1400867002669	thiamine phosphate binding site [chemical binding]; other site
1400867002670	active site
1400867002671	pyrophosphate binding site [ion binding]; other site
1400867002672	glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062
1400867002673	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
1400867002674	inhibitor-cofactor binding pocket; inhibition site
1400867002675	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1400867002676	catalytic residue [active]
1400867002677	Phosphopantetheine attachment site; Region: PP-binding; cl09936
1400867002678	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
1400867002679	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
1400867002680	active site
1400867002681	ATP-dependent helicase HepA; Validated; Region: PRK04914
1400867002682	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1400867002683	ATP binding site [chemical binding]; other site
1400867002684	putative Mg++ binding site [ion binding]; other site
1400867002685	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1400867002686	nucleotide binding region [chemical binding]; other site
1400867002687	ATP-binding site [chemical binding]; other site
1400867002688	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465
1400867002689	DNA-binding transcriptional repressor FabR; Provisional; Region: PRK11202
1400867002690	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1400867002691	Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_2; cd06216
1400867002692	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
1400867002693	FAD binding pocket [chemical binding]; other site
1400867002694	FAD binding motif [chemical binding]; other site
1400867002695	phosphate binding motif [ion binding]; other site
1400867002696	beta-alpha-beta structure motif; other site
1400867002697	NAD binding pocket [chemical binding]; other site
1400867002698	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
1400867002699	catalytic loop [active]
1400867002700	iron binding site [ion binding]; other site
1400867002701	Fatty acid desaturase; Region: FA_desaturase; pfam00487
1400867002702	The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506
1400867002703	putative di-iron ligands [ion binding]; other site
1400867002704	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
1400867002705	CoenzymeA binding site [chemical binding]; other site
1400867002706	subunit interaction site [polypeptide binding]; other site
1400867002707	PHB binding site; other site
1400867002708	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1400867002709	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1400867002710	Protein of unknown function (DUF541); Region: SIMPL; cl01077
1400867002711	diaminobutyrate--2-oxoglutarate aminotransferase; Provisional; Region: PRK06931
1400867002712	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
1400867002713	inhibitor-cofactor binding pocket; inhibition site
1400867002714	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1400867002715	catalytic residue [active]
1400867002716	DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450
1400867002717	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1400867002718	catalytic residue [active]
1400867002719	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
1400867002720	Streptomyces aureofaciens putative aldehyde dehydrogenase AldA (AAD23400)-like; Region: ALDH_AldA-AAD23400; cd07106
1400867002721	NAD(P) binding site [chemical binding]; other site
1400867002722	catalytic residues [active]
1400867002723	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
1400867002724	AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404
1400867002725	AsnC family; Region: AsnC_trans_reg; pfam01037
1400867002726	Pyruvate decarboxylase and related thiamine pyrophosphate-requiring enzymes [Carbohydrate transport and metabolism / Coenzyme metabolism / General function prediction only]; Region: COG3961
1400867002727	Pyrimidine (PYR) binding domain of pyruvate decarboxylase (PDC), indolepyruvate decarboxylase (IPDC) and related proteins; Region: TPP_PYR_PDC_IPDC_like; cd07038
1400867002728	dimer interface [polypeptide binding]; other site
1400867002729	PYR/PP interface [polypeptide binding]; other site
1400867002730	TPP binding site [chemical binding]; other site
1400867002731	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
1400867002732	Thiamine pyrophosphate (TPP) family, PDC_IPDC subfamily, TPP-binding module; composed of proteins similar to pyruvate decarboxylase (PDC) and indolepyruvate decarboxylase (IPDC). PDC, a key enzyme in alcoholic fermentation, catalyzes the conversion of...; Region: TPP_PDC_IPDC; cd02005
1400867002733	TPP-binding site [chemical binding]; other site
1400867002734	dimer interface [polypeptide binding]; other site
1400867002735	aromatic amino acid transporter; Provisional; Region: PRK10238
1400867002736	ABC-type phosphate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PstS; COG0226
1400867002737	Phosphate ATP-binding cassette transporter; Region: DUF3708; pfam12501
1400867002738	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573
1400867002739	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1400867002740	dimer interface [polypeptide binding]; other site
1400867002741	conserved gate region; other site
1400867002742	putative PBP binding loops; other site
1400867002743	ABC-ATPase subunit interface; other site
1400867002744	Domain of unknown function (DUF3333); Region: DUF3333; pfam11812
1400867002745	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581
1400867002746	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1400867002747	dimer interface [polypeptide binding]; other site
1400867002748	conserved gate region; other site
1400867002749	putative PBP binding loops; other site
1400867002750	ABC-ATPase subunit interface; other site
1400867002751	phosphate transporter ATP-binding protein; Provisional; Region: PRK14235
1400867002752	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
1400867002753	Walker A/P-loop; other site
1400867002754	ATP binding site [chemical binding]; other site
1400867002755	Q-loop/lid; other site
1400867002756	ABC transporter signature motif; other site
1400867002757	Walker B; other site
1400867002758	D-loop; other site
1400867002759	H-loop/switch region; other site
1400867002760	signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706
1400867002761	Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023
1400867002762	tandem repeat interface [polypeptide binding]; other site
1400867002763	oligomer interface [polypeptide binding]; other site
1400867002764	active site residues [active]
1400867002765	Predicted membrane protein (DUF2238); Region: DUF2238; pfam09997
1400867002766	adenylosuccinate lyase; Provisional; Region: PRK09285
1400867002767	PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598
1400867002768	tetramer interface [polypeptide binding]; other site
1400867002769	active site
1400867002770	putative lysogenization regulator; Reviewed; Region: PRK00218
1400867002771	Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482
1400867002772	tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998
1400867002773	Contains a crystal structure of the Nudix hydrolase from Nitrosomonas europaea, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_2; cd03675
1400867002774	nudix motif; other site
1400867002775	Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663
1400867002776	Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645
1400867002777	trimer interface [polypeptide binding]; other site
1400867002778	putative metal binding site [ion binding]; other site
1400867002779	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
1400867002780	D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686
1400867002781	Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936
1400867002782	5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346
1400867002783	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
1400867002784	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1400867002785	Peptidase family M23; Region: Peptidase_M23; pfam01551
1400867002786	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1400867002787	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1400867002788	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
1400867002789	putative effector binding pocket; other site
1400867002790	dimerization interface [polypeptide binding]; other site
1400867002791	AAA domain; Region: AAA_32; pfam13654
1400867002792	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cl00148
1400867002793	primary dimer interface [polypeptide binding]; other site
1400867002794	lon-related putative ATP-dependent protease; Region: lon_rel; TIGR00764
1400867002795	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
1400867002796	muropeptide transporter; Validated; Region: ampG; cl17669
1400867002797	muropeptide transporter; Validated; Region: ampG; cl17669
1400867002798	muropeptide transporter; Validated; Region: ampG; cl17669
1400867002799	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1400867002800	Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233
1400867002801	dimer interface [polypeptide binding]; other site
1400867002802	active site
1400867002803	metal binding site [ion binding]; metal-binding site
1400867002804	glutathione binding site [chemical binding]; other site
1400867002805	Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385
1400867002806	SBF-like CPA transporter family (DUF4137); Region: DUF4137; pfam13593
1400867002807	50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019
1400867002808	PAS domain S-box; Region: sensory_box; TIGR00229
1400867002809	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
1400867002810	Radical SAM superfamily; Region: Radical_SAM; pfam04055
1400867002811	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1400867002812	FeS/SAM binding site; other site
1400867002813	elongation factor P; Validated; Region: PRK00529
1400867002814	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
1400867002815	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
1400867002816	RNA binding site [nucleotide binding]; other site
1400867002817	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
1400867002818	RNA binding site [nucleotide binding]; other site
1400867002819	carbon starvation protein A; Provisional; Region: PRK15015
1400867002820	Carbon starvation protein CstA; Region: CstA; pfam02554
1400867002821	C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722
1400867002822	Protein of unknown function (DUF466); Region: DUF466; pfam04328
1400867002823	RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931
1400867002824	Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548
1400867002825	Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064
1400867002826	active site
1400867002827	Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548
1400867002828	type I secretion C-terminal target domain (VC_A0849 subclass); Region: T1SS_VCA0849; TIGR03661
1400867002829	PaaX-like protein; Region: PaaX; pfam07848
1400867002830	PaaX-like protein C-terminal domain; Region: PaaX_C; pfam08223
1400867002831	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1400867002832	NAD(P) binding site [chemical binding]; other site
1400867002833	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
1400867002834	active site
1400867002835	The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615
1400867002836	putative di-iron ligands [ion binding]; other site
1400867002837	The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615
1400867002838	Fatty acid desaturase; Region: FA_desaturase; pfam00487
1400867002839	putative di-iron ligands [ion binding]; other site
1400867002840	Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687
1400867002841	Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118
1400867002842	YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012
1400867002843	Isochorismatase family; Region: Isochorismatase; pfam00857
1400867002844	catalytic triad [active]
1400867002845	dimer interface [polypeptide binding]; other site
1400867002846	conserved cis-peptide bond; other site
1400867002847	LysR family transcriptional regulator; Provisional; Region: PRK14997
1400867002848	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1400867002849	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_4; cd08473
1400867002850	putative effector binding pocket; other site
1400867002851	putative dimerization interface [polypeptide binding]; other site
1400867002852	Trypsin; Region: Trypsin; pfam00089
1400867002853	active site
1400867002854	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
1400867002855	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
1400867002856	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
1400867002857	Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118
1400867002858	Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687
1400867002859	hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466
1400867002860	uncharacterized subgroup of aldehyde reductase and flavonoid reductase related proteins, extended (e) SDRs; Region: AR_FR_like_1_SDR_e; cd05228
1400867002861	putative NADP binding site [chemical binding]; other site
1400867002862	putative substrate binding site [chemical binding]; other site
1400867002863	active site
1400867002864	Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625
1400867002865	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1400867002866	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1400867002867	MoCF_BD: molybdenum cofactor (MoCF) binding domain (BD). This domain is found a variety of proteins involved in biosynthesis of molybdopterin cofactor, like MoaB, MogA, and MoeA. The domain is presumed to bind molybdopterin; Region: MoCF_BD; cl00451
1400867002868	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1400867002869	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1400867002870	Pirin-related protein [General function prediction only]; Region: COG1741
1400867002871	Pirin; Region: Pirin; pfam02678
1400867002872	Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171
1400867002873	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
1400867002874	tetramer interface [polypeptide binding]; other site
1400867002875	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1400867002876	catalytic residue [active]
1400867002877	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964
1400867002878	YheO-like PAS domain; Region: PAS_6; pfam08348
1400867002879	HTH domain; Region: HTH_22; pfam13309
1400867002880	Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375
1400867002881	Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193
1400867002882	FAD binding pocket [chemical binding]; other site
1400867002883	FAD binding motif [chemical binding]; other site
1400867002884	phosphate binding motif [ion binding]; other site
1400867002885	NAD binding pocket [chemical binding]; other site
1400867002886	The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; Region: A_NRPS_TlmIV_like; cd12114
1400867002887	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
1400867002888	acyl-activating enzyme (AAE) consensus motif; other site
1400867002889	AMP binding site [chemical binding]; other site
1400867002890	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1400867002891	Condensation domain; Region: Condensation; pfam00668
1400867002892	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
1400867002893	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
1400867002894	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1400867002895	ABC-ATPase subunit  interface; other site
1400867002896	dimer interface [polypeptide binding]; other site
1400867002897	putative PBP binding regions; other site
1400867002898	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1400867002899	ABC-ATPase subunit  interface; other site
1400867002900	dimer interface [polypeptide binding]; other site
1400867002901	putative PBP binding regions; other site
1400867002902	ABC-type enterochelin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CeuD; COG4604
1400867002903	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
1400867002904	Walker A/P-loop; other site
1400867002905	ATP binding site [chemical binding]; other site
1400867002906	Q-loop/lid; other site
1400867002907	ABC transporter signature motif; other site
1400867002908	Walker B; other site
1400867002909	D-loop; other site
1400867002910	H-loop/switch region; other site
1400867002911	ABC-type enterochelin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: CeuA; COG4607
1400867002912	Siderophore binding protein FatB.  These proteins have been shown to function as ABC-type initial receptors in the siderophore-mediated iron uptake in some eubacterial species.  They belong to the TroA superfamily of periplasmic metal binding proteins...; Region: FatB; cd01140
1400867002913	putative ligand binding residues [chemical binding]; other site
1400867002914	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
1400867002915	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
1400867002916	N-terminal plug; other site
1400867002917	ligand-binding site [chemical binding]; other site
1400867002918	Lysine/ornithine N-monooxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: IucD; COG3486
1400867002919	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1400867002920	Condensation domain; Region: Condensation; pfam00668
1400867002921	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
1400867002922	Nonribosomal peptide synthase; Region: NRPS; pfam08415
1400867002923	Condensation domain; Region: Condensation; pfam00668
1400867002924	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
1400867002925	Nonribosomal peptide synthase; Region: NRPS; pfam08415
1400867002926	enterobactin synthase subunit E; Provisional; Region: entE; PRK10946
1400867002927	2,3-dihydroxybenzoate-AMP ligase; Region: 23DHB-AMP_lg; cd05920
1400867002928	acyl-activating enzyme (AAE) consensus motif; other site
1400867002929	active site
1400867002930	AMP binding site [chemical binding]; other site
1400867002931	substrate binding site [chemical binding]; other site
1400867002932	Isochorismatase, also known as 2,3 dihydro-2,3 dihydroxybenzoate synthase, catalyses the conversion of isochorismate, in the presence of water, to 2,3-dihydroxybenzoate and pyruvate, via the hydrolysis of a vinyl ether, an uncommon reaction in biological...; Region: isochorismatase; cd01013
1400867002933	hydrophobic substrate binding pocket; other site
1400867002934	Isochorismatase family; Region: Isochorismatase; pfam00857
1400867002935	active site
1400867002936	conserved cis-peptide bond; other site
1400867002937	Aryl carrier domain [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3433
1400867002938	histidine decarboxylase; Provisional; Region: PRK02769
1400867002939	Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155
1400867002940	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1400867002941	catalytic residue [active]
1400867002942	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
1400867002943	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1400867002944	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1400867002945	Walker A/P-loop; other site
1400867002946	ATP binding site [chemical binding]; other site
1400867002947	Q-loop/lid; other site
1400867002948	ABC transporter signature motif; other site
1400867002949	Walker B; other site
1400867002950	D-loop; other site
1400867002951	H-loop/switch region; other site
1400867002952	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1400867002953	putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608
1400867002954	Walker A/P-loop; other site
1400867002955	ATP binding site [chemical binding]; other site
1400867002956	Q-loop/lid; other site
1400867002957	ABC transporter signature motif; other site
1400867002958	Walker B; other site
1400867002959	D-loop; other site
1400867002960	H-loop/switch region; other site
1400867002961	Thioesterase domain; Region: Thioesterase; pfam00975
1400867002962	4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648
1400867002963	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
1400867002964	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
1400867002965	Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409
1400867002966	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
1400867002967	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
1400867002968	Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717
1400867002969	substrate binding site [chemical binding]; other site
1400867002970	active site
1400867002971	Protein of unknown function (DUF817); Region: DUF817; pfam05675
1400867002972	Protein of unknown function (DUF3015); Region: DUF3015; pfam11220
1400867002973	Domain of unknown function (DUF4105); Region: DUF4105; pfam13387
1400867002974	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
1400867002975	beta-lactamase/D-alanine carboxypeptidase; Provisional; Region: ampC; PRK11289
1400867002976	GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate.  The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria.  In...; Region: GTP_cyclohydro1; cd00642
1400867002977	homodecamer interface [polypeptide binding]; other site
1400867002978	GTP cyclohydrolase I; Provisional; Region: PLN03044
1400867002979	active site
1400867002980	putative catalytic site residues [active]
1400867002981	zinc binding site [ion binding]; other site
1400867002982	GTP-CH-I/GFRP interaction surface; other site
1400867002983	xanthine dehydrogenase, small subunit; Region: xanthine_xdhA; TIGR02963
1400867002984	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
1400867002985	CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450
1400867002986	xanthine dehydrogenase, molybdopterin binding subunit; Region: xanthine_xdhB; TIGR02965
1400867002987	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
1400867002988	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
1400867002989	XdhC and CoxI family; Region: XdhC_CoxI; pfam02625
1400867002990	xanthine dehydrogenase accessory protein XdhC; Region: xanthine_xdhC; TIGR02964
1400867002991	XdhC Rossmann domain; Region: XdhC_C; pfam13478
1400867002992	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2840
1400867002993	Smr domain; Region: Smr; pfam01713
1400867002994	Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331
1400867002995	active site
1400867002996	ribulose/triose binding site [chemical binding]; other site
1400867002997	phosphate binding site [ion binding]; other site
1400867002998	substrate (anthranilate) binding pocket [chemical binding]; other site
1400867002999	product (indole) binding pocket [chemical binding]; other site
1400867003000	anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188
1400867003001	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
1400867003002	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
1400867003003	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
1400867003004	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
1400867003005	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
1400867003006	Peptidase family M1; Region: Peptidase_M1; pfam01433
1400867003007	Peptidase M1 Aminopeptidase N family incudes tricorn interacting factor F3, Endoplasmic reticulum aminopeptidase 1 (ERAP1), Aminopeptidase Q (APQ); Region: M1_APN_2; cd09601
1400867003008	Zn binding site [ion binding]; other site
1400867003009	Domain of unknown function (DUF3358); Region: DUF3358; pfam11838
1400867003010	para-aminobenzoate synthase component II; Provisional; Region: PRK08857
1400867003011	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
1400867003012	glutamine binding [chemical binding]; other site
1400867003013	catalytic triad [active]
1400867003014	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
1400867003015	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
1400867003016	X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP; cd01085
1400867003017	active site
1400867003018	Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104
1400867003019	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1400867003020	putative substrate translocation pore; other site
1400867003021	POT family; Region: PTR2; cl17359
1400867003022	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl17904
1400867003023	glutamine synthetase; Provisional; Region: glnA; PRK09469
1400867003024	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
1400867003025	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
1400867003026	Chorismate lyase; Region: Chor_lyase; cl01230
1400867003027	4-hydroxybenzoate octaprenyltransferase; Reviewed; Region: ubiA; PRK12848
1400867003028	UbiA prenyltransferase family; Region: UbiA; pfam01040
1400867003029	Secretory lipase; Region: LIP; pfam03583
1400867003030	Protein of unknown function (DUF2726); Region: DUF2726; pfam10881
1400867003031	Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605
1400867003032	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
1400867003033	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
1400867003034	NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371
1400867003035	Uncharacterized conserved protein [Function unknown]; Region: COG0327
1400867003036	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
1400867003037	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
1400867003038	protein binding site [polypeptide binding]; other site
1400867003039	multifunctional tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase; Reviewed; Region: cca; PRK10885
1400867003040	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
1400867003041	active site
1400867003042	NTP binding site [chemical binding]; other site
1400867003043	metal binding triad [ion binding]; metal-binding site
1400867003044	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
1400867003045	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
1400867003046	Zn2+ binding site [ion binding]; other site
1400867003047	Mg2+ binding site [ion binding]; other site
1400867003048	bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed; Region: PRK07232
1400867003049	Malic enzyme, N-terminal domain; Region: malic; pfam00390
1400867003050	NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311
1400867003051	putative NAD(P) binding site [chemical binding]; other site
1400867003052	Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280
1400867003053	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1400867003054	PAS fold; Region: PAS_3; pfam08447
1400867003055	heme pocket [chemical binding]; other site
1400867003056	putative active site [active]
1400867003057	PAS domain S-box; Region: sensory_box; TIGR00229
1400867003058	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1400867003059	putative active site [active]
1400867003060	heme pocket [chemical binding]; other site
1400867003061	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1400867003062	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1400867003063	metal binding site [ion binding]; metal-binding site
1400867003064	active site
1400867003065	I-site; other site
1400867003066	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
1400867003067	16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713
1400867003068	RNA methyltransferase, RsmE family; Region: TIGR00046
1400867003069	Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537
1400867003070	FAD binding site [chemical binding]; other site
1400867003071	S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476
1400867003072	S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401
1400867003073	homotetramer interface [polypeptide binding]; other site
1400867003074	ligand binding site [chemical binding]; other site
1400867003075	catalytic site [active]
1400867003076	NAD binding site [chemical binding]; other site
1400867003077	Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296
1400867003078	Carboxymuconolactone decarboxylase family; Region: CMD; cl00460
1400867003079	acyl-CoA dehydrogenase; Reviewed; Region: fadE; PRK09463
1400867003080	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
1400867003081	active site
1400867003082	Domain of unknown function (DUF1974); Region: DUF1974; pfam09317
1400867003083	lipoyl synthase; Provisional; Region: PRK05481
1400867003084	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1400867003085	FeS/SAM binding site; other site
1400867003086	soluble pyridine nucleotide transhydrogenase; Provisional; Region: PRK05249
1400867003087	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
1400867003088	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1400867003089	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
1400867003090	leucine-responsive transcriptional regulator; Provisional; Region: PRK11169
1400867003091	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1400867003092	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1400867003093	putative substrate translocation pore; other site
1400867003094	nitrite extrusion protein (nitrite facilitator); Region: 2A0108; TIGR00886
1400867003095	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1400867003096	Outer membrane protein W [Cell envelope biogenesis, outer membrane]; Region: OmpW; COG3047
1400867003097	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
1400867003098	active site
1400867003099	Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425
1400867003100	rRNA interaction site [nucleotide binding]; other site
1400867003101	S8 interaction site; other site
1400867003102	putative laminin-1 binding site; other site
1400867003103	elongation factor Ts; Provisional; Region: tsf; PRK09377
1400867003104	UBA/TS-N domain; Region: UBA; pfam00627
1400867003105	Elongation factor TS; Region: EF_TS; pfam00889
1400867003106	Elongation factor TS; Region: EF_TS; pfam00889
1400867003107	Protein of unknown function (DUF3465); Region: DUF3465; pfam11948
1400867003108	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
1400867003109	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
1400867003110	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1400867003111	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1400867003112	AzlC protein; Region: AzlC; cl00570
1400867003113	Branched-chain amino acid transport protein (AzlD); Region: AzlD; pfam05437
1400867003114	Protein of unknown function (DUF962); Region: DUF962; cl01879
1400867003115	Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797
1400867003116	Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330
1400867003117	Transglycosylase SLT domain; Region: SLT_2; pfam13406
1400867003118	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
1400867003119	N-acetyl-D-glucosamine binding site [chemical binding]; other site
1400867003120	catalytic residue [active]
1400867003121	rod shape-determining protein RodA; Region: rodA_shape; TIGR02210
1400867003122	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2904
1400867003123	7-cyano-7-deazaguanine reductase; Provisional; Region: queF; PRK11792
1400867003124	Enzyme related to GTP cyclohydrolase I [General function prediction only]; Region: COG0780
1400867003125	inner membrane transport permease; Provisional; Region: PRK15066
1400867003126	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
1400867003127	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
1400867003128	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
1400867003129	Walker A/P-loop; other site
1400867003130	ATP binding site [chemical binding]; other site
1400867003131	Q-loop/lid; other site
1400867003132	ABC transporter signature motif; other site
1400867003133	Walker B; other site
1400867003134	D-loop; other site
1400867003135	H-loop/switch region; other site
1400867003136	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
1400867003137	exodeoxyribonuclease X; Provisional; Region: PRK07983
1400867003138	active site
1400867003139	catalytic site [active]
1400867003140	substrate binding site [chemical binding]; other site
1400867003141	Protein of unknown function (DUF3820); Region: DUF3820; cl01411
1400867003142	Secretory lipase; Region: LIP; pfam03583
1400867003143	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
1400867003144	serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011
1400867003145	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
1400867003146	dimer interface [polypeptide binding]; other site
1400867003147	active site
1400867003148	glycine-pyridoxal phosphate binding site [chemical binding]; other site
1400867003149	folate binding site [chemical binding]; other site
1400867003150	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
1400867003151	AcrB/AcrD/AcrF family; Region: ACR_tran; pfam00873
1400867003152	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
1400867003153	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
1400867003154	HlyD family secretion protein; Region: HlyD_3; pfam13437
1400867003155	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1400867003156	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1400867003157	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472
1400867003158	putative effector binding pocket; other site
1400867003159	putative dimerization interface [polypeptide binding]; other site
1400867003160	lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096
1400867003161	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1400867003162	substrate binding pocket [chemical binding]; other site
1400867003163	membrane-bound complex binding site; other site
1400867003164	hinge residues; other site
1400867003165	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
1400867003166	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1400867003167	dimer interface [polypeptide binding]; other site
1400867003168	conserved gate region; other site
1400867003169	putative PBP binding loops; other site
1400867003170	ABC-ATPase subunit interface; other site
1400867003171	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
1400867003172	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1400867003173	dimer interface [polypeptide binding]; other site
1400867003174	conserved gate region; other site
1400867003175	putative PBP binding loops; other site
1400867003176	ABC-ATPase subunit interface; other site
1400867003177	ABC-type histidine transport system, ATPase component [Amino acid transport and metabolism]; Region: HisP; COG4598
1400867003178	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
1400867003179	Walker A/P-loop; other site
1400867003180	ATP binding site [chemical binding]; other site
1400867003181	Q-loop/lid; other site
1400867003182	ABC transporter signature motif; other site
1400867003183	Walker B; other site
1400867003184	D-loop; other site
1400867003185	H-loop/switch region; other site
1400867003186	Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076
1400867003187	4Fe-4S dicluster domain; Region: Fer4_10; pfam13237
1400867003188	putative protease; Provisional; Region: PRK15452
1400867003189	Peptidase family U32; Region: Peptidase_U32; pfam01136
1400867003190	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
1400867003191	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1400867003192	DNA-binding site [nucleotide binding]; DNA binding site
1400867003193	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1400867003194	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1400867003195	homodimer interface [polypeptide binding]; other site
1400867003196	catalytic residue [active]
1400867003197	Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384
1400867003198	hydroxyproline-2-epimerase; Provisional; Region: PRK13971
1400867003199	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
1400867003200	Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195
1400867003201	FAD binding pocket [chemical binding]; other site
1400867003202	FAD binding motif [chemical binding]; other site
1400867003203	phosphate binding motif [ion binding]; other site
1400867003204	beta-alpha-beta structure motif; other site
1400867003205	NAD binding pocket [chemical binding]; other site
1400867003206	Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281
1400867003207	homodimer interaction site [polypeptide binding]; other site
1400867003208	cofactor binding site; other site
1400867003209	Predicted membrane protein [Function unknown]; Region: COG3174
1400867003210	Domain of unknown function (DUF4010); Region: DUF4010; pfam13194
1400867003211	Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157
1400867003212	Type II/IV secretion system protein; Region: T2SE; pfam00437
1400867003213	PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129
1400867003214	Walker A motif; other site
1400867003215	ATP binding site [chemical binding]; other site
1400867003216	Walker B motif; other site
1400867003217	Bacterial OB fold (BOF) protein; Region: BOF; cl01196
1400867003218	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1400867003219	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1400867003220	active site
1400867003221	phosphorylation site [posttranslational modification]
1400867003222	intermolecular recognition site; other site
1400867003223	dimerization interface [polypeptide binding]; other site
1400867003224	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1400867003225	DNA binding site [nucleotide binding]
1400867003226	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1400867003227	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1400867003228	dimer interface [polypeptide binding]; other site
1400867003229	phosphorylation site [posttranslational modification]
1400867003230	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1400867003231	ATP binding site [chemical binding]; other site
1400867003232	Mg2+ binding site [ion binding]; other site
1400867003233	G-X-G motif; other site
1400867003234	Hemin uptake protein hemP; Region: hemP; cl10043
1400867003235	hypothetical protein; Provisional; Region: PRK08999
1400867003236	The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425
1400867003237	active site
1400867003238	8-oxo-dGMP binding site [chemical binding]; other site
1400867003239	nudix motif; other site
1400867003240	metal binding site [ion binding]; metal-binding site
1400867003241	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
1400867003242	thiamine phosphate binding site [chemical binding]; other site
1400867003243	active site
1400867003244	penicillin-binding protein 1B; Region: PBP_1b; TIGR02071
1400867003245	Transglycosylase; Region: Transgly; pfam00912
1400867003246	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
1400867003247	inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK01231
1400867003248	inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02231
1400867003249	Protein of unknown function (DUF1315); Region: DUF1315; pfam07023
1400867003250	hypothetical protein; Validated; Region: PRK09071
1400867003251	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
1400867003252	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
1400867003253	C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663
1400867003254	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
1400867003255	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
1400867003256	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
1400867003257	active site
1400867003258	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819
1400867003259	Chorismate mutase type II; Region: CM_2; cl00693
1400867003260	Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077
1400867003261	Prephenate dehydratase; Region: PDT; pfam00800
1400867003262	C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905
1400867003263	putative L-Phe binding site [chemical binding]; other site
1400867003264	bifunctional cyclohexadienyl dehydrogenase/ 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK14806
1400867003265	prephenate dehydrogenase; Validated; Region: PRK08507
1400867003266	EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556
1400867003267	hinge; other site
1400867003268	active site
1400867003269	Xaa-His dipeptidase; Region: aa-his-dipept; TIGR01893
1400867003270	M20 Peptidase D has specificity for beta-alanyl-L-histidine dipeptide; Region: M20_pepD; cd03890
1400867003271	metal binding site [ion binding]; metal-binding site
1400867003272	dimer interface [polypeptide binding]; other site
1400867003273	RNA 3'-terminal-phosphate cyclase; Provisional; Region: PRK04204
1400867003274	This domain family includes the Enolpyruvate transferase (EPT) family and the RNA 3' phosphate cyclase family (RTPC). These 2 families differ in that EPT is formed by 3 repeats of an alpha-beta structural domain while  RTPC has 3 similar repeats...; Region: EPT_RTPC-like; cl00288
1400867003275	putative active site [active]
1400867003276	putative septicolysin, cholesterol-dependent cytolysin family and related proteins; Region: septicolysin_like; cd12208
1400867003277	oligomer interface [polypeptide binding]; other site
1400867003278	Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139
1400867003279	hypothetical protein; Reviewed; Region: PRK09588
1400867003280	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
1400867003281	Sigma54-dependent transcription regulator containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: RtcR; COG4650
1400867003282	Regulator of RNA terminal phosphate cyclase; Region: RtcR; pfam06956
1400867003283	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1400867003284	Walker A motif; other site
1400867003285	ATP binding site [chemical binding]; other site
1400867003286	Walker B motif; other site
1400867003287	arginine finger; other site
1400867003288	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2945
1400867003289	hypothetical protein; Validated; Region: PRK02101
1400867003290	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4339
1400867003291	Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728
1400867003292	ThiS interaction site; other site
1400867003293	putative active site [active]
1400867003294	tetramer interface [polypeptide binding]; other site
1400867003295	ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565
1400867003296	thiS-thiF/thiG interaction site; other site
1400867003297	Uncharacterized small membrane protein [Function unknown]; Region: COG2363
1400867003298	RNA polymerase factor sigma-32; Reviewed; Region: PRK06596
1400867003299	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
1400867003300	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1400867003301	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1400867003302	DNA binding residues [nucleotide binding]
1400867003303	SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain.  SirA (also known as UvrY,  and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291
1400867003304	CPxP  motif; other site
1400867003305	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
1400867003306	DNA-binding site [nucleotide binding]; DNA binding site
1400867003307	RNA-binding motif; other site
1400867003308	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
1400867003309	DEAD-like helicases superfamily; Region: DEXDc; smart00487
1400867003310	ATP binding site [chemical binding]; other site
1400867003311	Mg++ binding site [ion binding]; other site
1400867003312	motif III; other site
1400867003313	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1400867003314	nucleotide binding region [chemical binding]; other site
1400867003315	ATP-binding site [chemical binding]; other site
1400867003316	Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135
1400867003317	putative FMN binding site [chemical binding]; other site
1400867003318	NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094
1400867003319	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
1400867003320	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
1400867003321	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
1400867003322	catalytic core [active]
1400867003323	Type II secretion system (T2SS), protein L; Region: T2SL; pfam05134
1400867003324	GspL periplasmic domain; Region: GspL_C; cl14909
1400867003325	Type II secretion system (T2SS), protein M; Region: T2SM; cl01222
1400867003326	dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286
1400867003327	Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738
1400867003328	quinone interaction residues [chemical binding]; other site
1400867003329	active site
1400867003330	catalytic residues [active]
1400867003331	FMN binding site [chemical binding]; other site
1400867003332	substrate binding site [chemical binding]; other site
1400867003333	Colicin V production protein; Region: Colicin_V; pfam02674
1400867003334	amidophosphoribosyltransferase; Provisional; Region: PRK09246
1400867003335	Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of  glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715
1400867003336	active site
1400867003337	tetramer interface [polypeptide binding]; other site
1400867003338	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1400867003339	active site
1400867003340	Peptidase family M48; Region: Peptidase_M48; cl12018
1400867003341	bifunctional glyoxylate/hydroxypyruvate reductase B; Provisional; Region: PRK15409
1400867003342	D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301
1400867003343	dimerization interface [polypeptide binding]; other site
1400867003344	ligand binding site [chemical binding]; other site
1400867003345	NADP binding site [chemical binding]; other site
1400867003346	catalytic site [active]
1400867003347	Putative Zn-dependent protease, contains TPR repeats [General function prediction only]; Region: COG4783
1400867003348	Peptidase family M48; Region: Peptidase_M48; cl12018
1400867003349	Yqey-like protein; Region: YqeY; pfam09424
1400867003350	30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270
1400867003351	UGMP family protein; Validated; Region: PRK09604
1400867003352	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
1400867003353	Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG2607
1400867003354	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1400867003355	Walker A motif; other site
1400867003356	ATP binding site [chemical binding]; other site
1400867003357	Walker B motif; other site
1400867003358	Domain of unknown function (DUF3336); Region: DUF3336; pfam11815
1400867003359	Triacylglycerol lipase 3, 4, and 5 and Sugar-Dependent 1 lipase; Region: Pat_TGL3-4-5_SDP1; cd07206
1400867003360	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752
1400867003361	active site
1400867003362	nucleophile elbow; other site
1400867003363	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
1400867003364	substrate binding site [chemical binding]; other site
1400867003365	activation loop (A-loop); other site
1400867003366	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
1400867003367	Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831
1400867003368	POTRA domain, ShlB-type; Region: POTRA_2; pfam08479
1400867003369	Haemolysin secretion/activation protein ShlB/FhaC/HecB; Region: ShlB; pfam03865
1400867003370	haemagglutination activity domain; Region: Haemagg_act; pfam05860
1400867003371	Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210
1400867003372	Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332
1400867003373	Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332
1400867003374	Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332
1400867003375	Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332
1400867003376	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1400867003377	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1400867003378	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
1400867003379	dimerization interface [polypeptide binding]; other site
1400867003380	beta alanine--pyruvate transaminase; Provisional; Region: PRK09221
1400867003381	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
1400867003382	inhibitor-cofactor binding pocket; inhibition site
1400867003383	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1400867003384	catalytic residue [active]
1400867003385	Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085
1400867003386	methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722
1400867003387	tetrameric interface [polypeptide binding]; other site
1400867003388	NAD binding site [chemical binding]; other site
1400867003389	catalytic residues [active]
1400867003390	gamma-aminobutyrate permease; Region: GABAperm; TIGR01773
1400867003391	Uncharacterized protein conserved in bacteria (DUF2171); Region: DUF2171; pfam09939
1400867003392	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
1400867003393	active site
1400867003394	GlcNAc-PI de-N-acetylase; Region: PIG-L; pfam02585
1400867003395	Methyltransferase domain; Region: Methyltransf_31; pfam13847
1400867003396	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1400867003397	S-adenosylmethionine binding site [chemical binding]; other site
1400867003398	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
1400867003399	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
1400867003400	active site
1400867003401	Bacterial OB fold (BOF) protein; Region: BOF; cl01196
1400867003402	Sensors of blue-light using FAD; Region: BLUF; pfam04940
1400867003403	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
1400867003404	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
1400867003405	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1400867003406	Helix-turn-helix domain; Region: HTH_18; pfam12833
1400867003407	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1400867003408	Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167
1400867003409	alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561
1400867003410	Na+/glutamate symporter [Amino acid transport and metabolism]; Region: GltS; COG0786
1400867003411	Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG2607
1400867003412	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1400867003413	Walker A motif; other site
1400867003414	ATP binding site [chemical binding]; other site
1400867003415	Walker B motif; other site
1400867003416	Transcriptional regulators [Transcription]; Region: FadR; COG2186
1400867003417	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1400867003418	DNA-binding site [nucleotide binding]; DNA binding site
1400867003419	FCD domain; Region: FCD; pfam07729
1400867003420	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1400867003421	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1400867003422	Spore Coat Protein U domain; Region: SCPU; pfam05229
1400867003423	Spore Coat Protein U domain; Region: SCPU; cl02253
1400867003424	Spore Coat Protein U domain; Region: SCPU; pfam05229
1400867003425	P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121
1400867003426	Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345
1400867003427	P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188
1400867003428	Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577
1400867003429	PapC C-terminal domain; Region: PapC_C; pfam13953
1400867003430	Spore Coat Protein U domain; Region: SCPU; cl02253
1400867003431	Spore Coat Protein U domain; Region: SCPU; pfam05229
1400867003432	proline/glycine betaine transporter; Provisional; Region: PRK10642
1400867003433	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1400867003434	putative substrate translocation pore; other site
1400867003435	Osmosensory transporter coiled coil; Region: Osmo_CC; pfam08946
1400867003436	Hydrolase of X-linked nucleoside diphosphate N terminal; Region: Nudix_N; pfam12535
1400867003437	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_14; cd04672
1400867003438	nudix motif; other site
1400867003439	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
1400867003440	Zn2+ binding site [ion binding]; other site
1400867003441	Mg2+ binding site [ion binding]; other site
1400867003442	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
1400867003443	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
1400867003444	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1400867003445	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1400867003446	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
1400867003447	EamA-like transporter family; Region: EamA; pfam00892
1400867003448	EamA-like transporter family; Region: EamA; pfam00892
1400867003449	Paraquat-inducible protein A; Region: PqiA; pfam04403
1400867003450	Paraquat-inducible protein A; Region: PqiA; pfam04403
1400867003451	mce related protein; Region: MCE; pfam02470
1400867003452	mce related protein; Region: MCE; pfam02470
1400867003453	mce related protein; Region: MCE; pfam02470
1400867003454	Protein of unknown function (DUF330); Region: DUF330; pfam03886
1400867003455	Predicted transcriptional regulator [Transcription]; Region: COG1959
1400867003456	Transcriptional regulator; Region: Rrf2; pfam02082
1400867003457	Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492
1400867003458	Aspartate racemase [Cell envelope biogenesis, outer membrane]; Region: RacX; COG1794
1400867003459	aspartate racemase; Region: asp_race; TIGR00035
1400867003460	aromatic amino acid exporter; Provisional; Region: PRK11689
1400867003461	EamA-like transporter family; Region: EamA; pfam00892
1400867003462	Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133
1400867003463	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
1400867003464	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1400867003465	Coenzyme A binding pocket [chemical binding]; other site
1400867003466	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1400867003467	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl17904
1400867003468	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1400867003469	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1400867003470	C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663
1400867003471	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
1400867003472	hydroxyacylglutathione hydrolase; Region: GSH_gloB; TIGR03413
1400867003473	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1400867003474	dimer interface [polypeptide binding]; other site
1400867003475	conserved gate region; other site
1400867003476	ABC-ATPase subunit interface; other site
1400867003477	DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153
1400867003478	ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258
1400867003479	Walker A/P-loop; other site
1400867003480	ATP binding site [chemical binding]; other site
1400867003481	Q-loop/lid; other site
1400867003482	ABC transporter signature motif; other site
1400867003483	Walker B; other site
1400867003484	D-loop; other site
1400867003485	H-loop/switch region; other site
1400867003486	NIL domain; Region: NIL; pfam09383
1400867003487	ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464
1400867003488	NLPA lipoprotein; Region: Lipoprotein_9; pfam03180
1400867003489	phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885
1400867003490	Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844
1400867003491	Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071
1400867003492	Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843
1400867003493	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881
1400867003494	Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal  ATIC formylase domain that formylates...; Region: IMPCH; cd01421
1400867003495	purine monophosphate binding site [chemical binding]; other site
1400867003496	dimer interface [polypeptide binding]; other site
1400867003497	putative catalytic residues [active]
1400867003498	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798
1400867003499	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362
1400867003500	Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420
1400867003501	MJ0042 family finger-like domain; Region: MJ0042_CXXC; TIGR02098
1400867003502	Protein of unknown function (DUF3426); Region: DUF3426; pfam11906
1400867003503	Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325
1400867003504	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1400867003505	S-adenosylmethionine binding site [chemical binding]; other site
1400867003506	tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192
1400867003507	NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206
1400867003508	GidA associated domain 3; Region: GIDA_assoc_3; pfam13932
1400867003509	Predicted transcriptional regulator [Transcription]; Region: COG2378
1400867003510	WYL domain; Region: WYL; pfam13280
1400867003511	Uncharacterized conserved protein [Function unknown]; Region: COG2308
1400867003512	A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168
1400867003513	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
1400867003514	Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379
1400867003515	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
1400867003516	Predicted proteasome-type protease [Posttranslational modification, protein turnover, chaperones]; Region: COG3484
1400867003517	Bacterial proteasome, beta subunit. The 20S proteasome, multisubunit proteolytic complex, is the central enzyme of nonlysosomal protein degradation in both the cytosol and nucleus. It is composed of 28 subunits arranged as four homoheptameric rings that...; Region: proteasome_beta_bacterial; cd03765
1400867003518	alanine racemase; Reviewed; Region: alr; PRK00053
1400867003519	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827
1400867003520	active site
1400867003521	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
1400867003522	substrate binding site [chemical binding]; other site
1400867003523	catalytic residues [active]
1400867003524	dimer interface [polypeptide binding]; other site
1400867003525	replicative DNA helicase; Region: DnaB; TIGR00665
1400867003526	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
1400867003527	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
1400867003528	Walker A motif; other site
1400867003529	ATP binding site [chemical binding]; other site
1400867003530	Walker B motif; other site
1400867003531	DNA binding loops [nucleotide binding]
1400867003532	50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137
1400867003533	Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281
1400867003534	Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948
1400867003535	30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391
1400867003536	30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453
1400867003537	protoheme IX farnesyltransferase; Provisional; Region: PRK04375
1400867003538	UbiA prenyltransferase family; Region: UbiA; pfam01040
1400867003539	cytochrome o ubiquinol oxidase subunit IV; Provisional; Region: PRK10582
1400867003540	Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane.  It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863
1400867003541	Subunit I/III interface [polypeptide binding]; other site
1400867003542	Subunit III/IV interface [polypeptide binding]; other site
1400867003543	Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843
1400867003544	Ubiquinol oxidase subunit I.  Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane.  It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662
1400867003545	D-pathway; other site
1400867003546	Putative ubiquinol binding site [chemical binding]; other site
1400867003547	Low-spin heme (heme b) binding site [chemical binding]; other site
1400867003548	Putative water exit pathway; other site
1400867003549	Binuclear center (heme o3/CuB) [ion binding]; other site
1400867003550	K-pathway; other site
1400867003551	Putative proton exit pathway; other site
1400867003552	cytochrome o ubiquinol oxidase subunit II; Region: CyoA; TIGR01433
1400867003553	COX Aromatic Rich Motif; Region: COX_ARM; pfam06481
1400867003554	Domain of unknown function (DUF4339); Region: DUF4339; pfam14237
1400867003555	RDD family; Region: RDD; pfam06271
1400867003556	phosphoenolpyruvate synthase; Validated; Region: PRK06464
1400867003557	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
1400867003558	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
1400867003559	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
1400867003560	PEP synthetase regulatory protein; Provisional; Region: PRK05339
1400867003561	poly-beta-1,6 N-acetyl-D-glucosamine export porin PgaA; Region: PGA_TPR_OMP; TIGR03939
1400867003562	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
1400867003563	binding surface
1400867003564	TPR motif; other site
1400867003565	poly-beta-1,6-N-acetyl-D-glucosamine N-deacetylase PgaB; Region: deacetyl_PgaB; TIGR03938
1400867003566	N-terminal putative catalytic polysaccharide deacetylase domain of bacterial poly-beta-1,6-N-acetyl-D-glucosamine N-deacetylase PgaB, and similar proteins; Region: CE4_PgaB_5s; cd10964
1400867003567	putative active site [active]
1400867003568	putative metal binding site [ion binding]; other site
1400867003569	N-glycosyltransferase; Provisional; Region: PRK11204
1400867003570	CESA_like is  the cellulose synthase superfamily; Region: CESA_like; cd06423
1400867003571	DXD motif; other site
1400867003572	PgaD-like protein; Region: PgaD; pfam13994
1400867003573	luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558
1400867003574	probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858
1400867003575	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1400867003576	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1400867003577	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
1400867003578	putative effector binding pocket; other site
1400867003579	dimerization interface [polypeptide binding]; other site
1400867003580	Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693
1400867003581	Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141
1400867003582	potential catalytic triad [active]
1400867003583	conserved cys residue [active]
1400867003584	peptide chain release factor 1; Validated; Region: prfA; PRK00591
1400867003585	This domain is found in peptide chain release factors; Region: PCRF; smart00937
1400867003586	RF-1 domain; Region: RF-1; pfam00472
1400867003587	N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328
1400867003588	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1400867003589	Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625
1400867003590	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
1400867003591	SurA N-terminal domain; Region: SurA_N; pfam09312
1400867003592	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1400867003593	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08217
1400867003594	17hydroxysteroid dehydrogenase type 10 (HSD10)-like, classical (c) SDRs; Region: HSD10-like_SDR_c; cd05371
1400867003595	NAD binding site [chemical binding]; other site
1400867003596	homodimer interface [polypeptide binding]; other site
1400867003597	homotetramer interface [polypeptide binding]; other site
1400867003598	active site
1400867003599	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
1400867003600	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
1400867003601	active site
1400867003602	Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365
1400867003603	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1400867003604	acyl-activating enzyme (AAE) consensus motif; other site
1400867003605	AMP binding site [chemical binding]; other site
1400867003606	active site
1400867003607	CoA binding site [chemical binding]; other site
1400867003608	Flavin reductase like domain; Region: Flavin_Reduct; smart00903
1400867003609	molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690
1400867003610	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
1400867003611	ATP binding site [chemical binding]; other site
1400867003612	substrate interface [chemical binding]; other site
1400867003613	Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661
1400867003614	ABC1 family; Region: ABC1; cl17513
1400867003615	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
1400867003616	substrate binding site [chemical binding]; other site
1400867003617	activation loop (A-loop); other site
1400867003618	Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534
1400867003619	homooctamer interface [polypeptide binding]; other site
1400867003620	active site
1400867003621	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cl00233
1400867003622	catalytic center binding site [active]
1400867003623	ATP binding site [chemical binding]; other site
1400867003624	potassium-transporting ATPase subunit A; Provisional; Region: PRK05482
1400867003625	potassium-transporting ATPase subunit B; Provisional; Region: PRK01122
1400867003626	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
1400867003627	Soluble P-type ATPase [General function prediction only]; Region: COG4087
1400867003628	potassium-transporting ATPase subunit C; Reviewed; Region: PRK00315
1400867003629	Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205
1400867003630	Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702
1400867003631	USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987
1400867003632	Ligand Binding Site [chemical binding]; other site
1400867003633	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1400867003634	dimer interface [polypeptide binding]; other site
1400867003635	phosphorylation site [posttranslational modification]
1400867003636	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1400867003637	ATP binding site [chemical binding]; other site
1400867003638	Mg2+ binding site [ion binding]; other site
1400867003639	G-X-G motif; other site
1400867003640	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1400867003641	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1400867003642	active site
1400867003643	phosphorylation site [posttranslational modification]
1400867003644	intermolecular recognition site; other site
1400867003645	dimerization interface [polypeptide binding]; other site
1400867003646	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1400867003647	DNA binding site [nucleotide binding]
1400867003648	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
1400867003649	Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174
1400867003650	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
1400867003651	Protein of unknown function (DUF2799); Region: DUF2799; pfam10973
1400867003652	Demethoxyubiquinone hydroxylase, ferritin-like diiron-binding domain; Region: DMQH; cd01042
1400867003653	diiron binding motif [ion binding]; other site
1400867003654	lysophospholipid transporter LplT; Provisional; Region: PRK11195
1400867003655	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1400867003656	putative substrate translocation pore; other site
1400867003657	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
1400867003658	Surface antigen; Region: Bac_surface_Ag; pfam01103
1400867003659	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911
1400867003660	Family of unknown function (DUF490); Region: DUF490; pfam04357
1400867003661	bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238
1400867003662	Aconitase B swivel domain. Aconitate hydratase B is involved in energy metabolism as part of the TCA cycle. It catalyses the formation of cis-aconitate from citrate. This is the aconitase swivel domain, which undergoes swivelling conformational change in...; Region: AcnB_Swivel; cd01576
1400867003663	substrate binding site [chemical binding]; other site
1400867003664	Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle; Region: AcnB; cd01581
1400867003665	substrate binding site [chemical binding]; other site
1400867003666	ligand binding site [chemical binding]; other site
1400867003667	Ion transport protein; Region: Ion_trans; pfam00520
1400867003668	Ion channel; Region: Ion_trans_2; pfam07885
1400867003669	CCC1-related family of proteins; Region: CCC1_like; cl00278
1400867003670	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
1400867003671	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1400867003672	putative substrate translocation pore; other site
1400867003673	conjugal transfer nickase/helicase TraI; Provisional; Region: PRK14712
1400867003674	Domain of unknown function (DUF4198); Region: DUF4198; pfam10670
1400867003675	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1400867003676	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1400867003677	The C-terminal substrate binding domain of LysR-type transcriptional regulator metR, which regulates the expression of methionine biosynthetic genes, contains type 2 periplasmic binding fold; Region: PBP2_MetR; cd08441
1400867003678	putative dimerization interface [polypeptide binding]; other site
1400867003679	Protein of unknown function (DUF441); Region: DUF441; pfam04284
1400867003680	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
1400867003681	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1400867003682	RNA binding surface [nucleotide binding]; other site
1400867003683	Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553
1400867003684	active site
1400867003685	uracil binding [chemical binding]; other site
1400867003686	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
1400867003687	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1400867003688	Coenzyme A binding pocket [chemical binding]; other site
1400867003689	RelB antitoxin; Region: RelB; cl01171
1400867003690	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
1400867003691	Pseudouridine synthase, a subgroup of the RluA family; Region: PSRA_1; cd02558
1400867003692	probable active site [active]
1400867003693	Uncharacterized P-loop hydrolase UPF0079; Region: UPF0079; cl00520
1400867003694	DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095
1400867003695	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1400867003696	ATP binding site [chemical binding]; other site
1400867003697	Mg2+ binding site [ion binding]; other site
1400867003698	G-X-G motif; other site
1400867003699	MutL_Trans_MutL: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to Escherichia coli MutL.  EcMutL belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family.  This transducer domain is homologous to the second...; Region: MutL_Trans_MutL; cd03482
1400867003700	ATP binding site [chemical binding]; other site
1400867003701	MutL C terminal dimerisation domain; Region: MutL_C; pfam08676
1400867003702	tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324
1400867003703	tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091
1400867003704	bacterial Hfq-like; Region: Hfq; cd01716
1400867003705	hexamer interface [polypeptide binding]; other site
1400867003706	Sm1 motif; other site
1400867003707	RNA binding site [nucleotide binding]; other site
1400867003708	Sm2 motif; other site
1400867003709	EamA-like transporter family; Region: EamA; pfam00892
1400867003710	phosphonate utilization associated putative membrane protein; Region: phn_DUF6; TIGR03340
1400867003711	NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149
1400867003712	dimer interface [polypeptide binding]; other site
1400867003713	FMN binding site [chemical binding]; other site
1400867003714	Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398
1400867003715	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
1400867003716	putative active site [active]
1400867003717	putative metal binding site [ion binding]; other site
1400867003718	cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920
1400867003719	substrate binding site [chemical binding]; other site
1400867003720	glutaminyl-tRNA synthetase; Provisional; Region: PRK05347
1400867003721	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
1400867003722	active site
1400867003723	HIGH motif; other site
1400867003724	nucleotide binding site [chemical binding]; other site
1400867003725	catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807
1400867003726	KMSKS motif; other site
1400867003727	tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950
1400867003728	GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518
1400867003729	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741
1400867003730	catalytic triad [active]
1400867003731	ethanolamine ammonia-lyase small subunit; Provisional; Region: PRK05465
1400867003732	ethanolamine ammonia lyase large subunit; Provisional; Region: PRK15067
1400867003733	Ethanolamine ammonia lyase large subunit (EutB); Region: EutB; pfam06751
1400867003734	ethanolamine permease; Region: 2A0305; TIGR00908
1400867003735	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
1400867003736	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
1400867003737	NAD(P) binding site [chemical binding]; other site
1400867003738	catalytic residues [active]
1400867003739	Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862
1400867003740	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
1400867003741	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
1400867003742	Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176
1400867003743	Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454
1400867003744	dimer interface [polypeptide binding]; other site
1400867003745	active site
1400867003746	metal binding site [ion binding]; metal-binding site
1400867003747	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1400867003748	PIF1-like helicase; Region: PIF1; pfam05970
1400867003749	Walker A motif; other site
1400867003750	ATP binding site [chemical binding]; other site
1400867003751	Walker B motif; other site
1400867003752	5-carboxymethyl-2-hydroxymuconate isomerase (CHMI) is a trimeric enzyme catalyzing the isomerization of the unsaturated ketone 5-(carboxymethyl)-2-hydroxymuconate to 5-(carboxymethyl)-2-oxo-3-hexene-1,6-dionate. This is one step in the...; Region: CHMI; cd00580
1400867003753	putative substrate binding pocket [chemical binding]; other site
1400867003754	trimer interface [polypeptide binding]; other site
1400867003755	4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170
1400867003756	substrate binding site [chemical binding]; other site
1400867003757	multimerization interface [polypeptide binding]; other site
1400867003758	ATP binding site [chemical binding]; other site
1400867003759	aminopeptidase N; Provisional; Region: pepN; PRK14015
1400867003760	Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_1; cd09600
1400867003761	active site
1400867003762	Zn binding site [ion binding]; other site
1400867003763	Spore Coat Protein U domain; Region: SCPU; pfam05229
1400867003764	P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121
1400867003765	Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345
1400867003766	P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188
1400867003767	Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577
1400867003768	PapC C-terminal domain; Region: PapC_C; pfam13953
1400867003769	Spore Coat Protein U domain; Region: SCPU; pfam05229
1400867003770	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
1400867003771	Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of  glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570
1400867003772	C-terminal domain interface [polypeptide binding]; other site
1400867003773	GSH binding site (G-site) [chemical binding]; other site
1400867003774	dimer interface [polypeptide binding]; other site
1400867003775	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299
1400867003776	N-terminal domain interface [polypeptide binding]; other site
1400867003777	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1400867003778	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
1400867003779	NAD(P) binding site [chemical binding]; other site
1400867003780	active site
1400867003781	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1400867003782	active site
1400867003783	chorismate mutase; Provisional; Region: PRK08055
1400867003784	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
1400867003785	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1400867003786	putative DNA binding site [nucleotide binding]; other site
1400867003787	putative Zn2+ binding site [ion binding]; other site
1400867003788	AsnC family; Region: AsnC_trans_reg; pfam01037
1400867003789	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1400867003790	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1400867003791	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
1400867003792	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
1400867003793	N-terminal plug; other site
1400867003794	ligand-binding site [chemical binding]; other site
1400867003795	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
1400867003796	Mechanosensitive ion channel; Region: MS_channel; pfam00924
1400867003797	synaptic vesicle protein SV2; Region: synapt_SV2; TIGR01299
1400867003798	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1400867003799	Coenzyme A binding pocket [chemical binding]; other site
1400867003800	Outer membrane receptor for ferric coprogen and ferric-rhodotorulic acid [Inorganic ion transport and metabolism]; Region: FhuE; COG4773
1400867003801	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
1400867003802	N-terminal plug; other site
1400867003803	ligand-binding site [chemical binding]; other site
1400867003804	Outer membrane protein W [Cell envelope biogenesis, outer membrane]; Region: OmpW; COG3047
1400867003805	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
1400867003806	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1400867003807	Walker A/P-loop; other site
1400867003808	ATP binding site [chemical binding]; other site
1400867003809	Q-loop/lid; other site
1400867003810	ABC transporter signature motif; other site
1400867003811	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1400867003812	ABC transporter; Region: ABC_tran_2; pfam12848
1400867003813	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1400867003814	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
1400867003815	Ligand Binding Site [chemical binding]; other site
1400867003816	dipeptidase, putative; Region: dipeptidaselike; TIGR01887
1400867003817	RDD family; Region: RDD; pfam06271
1400867003818	magnesium-transporting ATPase MgtA; Provisional; Region: PRK10517
1400867003819	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690
1400867003820	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
1400867003821	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
1400867003822	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
1400867003823	Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285
1400867003824	MgtC family; Region: MgtC; pfam02308
1400867003825	Benzoate membrane transport protein; Region: BenE; pfam03594
1400867003826	benzoate transporter; Region: benE; TIGR00843
1400867003827	leucine-responsive transcriptional regulator; Provisional; Region: PRK11169
1400867003828	Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412
1400867003829	AsnC family; Region: AsnC_trans_reg; pfam01037
1400867003830	leucine export protein LeuE; Provisional; Region: PRK10958
1400867003831	transaldolase-like protein; Provisional; Region: PTZ00411
1400867003832	Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957
1400867003833	active site
1400867003834	dimer interface [polypeptide binding]; other site
1400867003835	catalytic residue [active]
1400867003836	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1400867003837	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1400867003838	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
1400867003839	dimerization interface [polypeptide binding]; other site
1400867003840	Bacterial Transmembrane Pair family; Region: BTP; pfam05232
1400867003841	Bacterial Transmembrane Pair family; Region: BTP; pfam05232
1400867003842	acetyl-CoA acetyltransferase; Provisional; Region: PRK09268
1400867003843	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
1400867003844	dimer interface [polypeptide binding]; other site
1400867003845	active site
1400867003846	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08261
1400867003847	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1400867003848	NAD(P) binding site [chemical binding]; other site
1400867003849	active site
1400867003850	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
1400867003851	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
1400867003852	active site 2 [active]
1400867003853	active site 1 [active]
1400867003854	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
1400867003855	Beta-lactamase; Region: Beta-lactamase; pfam00144
1400867003856	TetR family transcriptional regulator; Provisional; Region: PRK14996
1400867003857	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1400867003858	methyl viologen resistance protein SmvA; Provisional; Region: PRK14995
1400867003859	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1400867003860	putative substrate translocation pore; other site
1400867003861	DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14960
1400867003862	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1400867003863	Walker A motif; other site
1400867003864	ATP binding site [chemical binding]; other site
1400867003865	Walker B motif; other site
1400867003866	arginine finger; other site
1400867003867	DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169
1400867003868	Phosphoesterase family; Region: Phosphoesterase; pfam04185
1400867003869	phospholipase C, phosphocholine-specific, Pseudomonas-type; Region: PC_PLC; TIGR03396
1400867003870	Phosphoesterase family; Region: Phosphoesterase; pfam04185
1400867003871	Domain of unknown function (DUF756); Region: DUF756; pfam05506
1400867003872	Domain of unknown function (DUF756); Region: DUF756; pfam05506
1400867003873	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
1400867003874	active site
1400867003875	Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454
1400867003876	5-hydroxyvalerate dehydrogenase (HVD) catalyzes the oxidation of 5-hydroxyvalerate to 5-oxovalerate with NAD+ as cofactor; Region: HVD; cd08193
1400867003877	putative active site [active]
1400867003878	metal binding site [ion binding]; metal-binding site
1400867003879	Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282
1400867003880	Low molecular weight phosphatase family; Region: LMWPc; cd00115
1400867003881	Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451
1400867003882	active site
1400867003883	UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK00046
1400867003884	FAD binding domain; Region: FAD_binding_4; pfam01565
1400867003885	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873
1400867003886	Uncharacterized conserved protein [Function unknown]; Region: COG1434
1400867003887	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
1400867003888	putative active site [active]
1400867003889	Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267
1400867003890	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
1400867003891	Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069
1400867003892	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
1400867003893	active site
1400867003894	FMN binding site [chemical binding]; other site
1400867003895	substrate binding site [chemical binding]; other site
1400867003896	3Fe-4S cluster binding site [ion binding]; other site
1400867003897	Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182
1400867003898	PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703
1400867003899	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1400867003900	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1400867003901	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1400867003902	putative 3-phenylpropionic acid transporter; Provisional; Region: PRK11128
1400867003903	putative substrate translocation pore; other site
1400867003904	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
1400867003905	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
1400867003906	ATP-grasp domain; Region: ATP-grasp_4; cl17255
1400867003907	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
1400867003908	acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302
1400867003909	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
1400867003910	carboxyltransferase (CT) interaction site; other site
1400867003911	biotinylation site [posttranslational modification]; other site
1400867003912	Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466
1400867003913	Dehydroquinase class II; Region: DHquinase_II; pfam01220
1400867003914	trimer interface [polypeptide binding]; other site
1400867003915	active site
1400867003916	dimer interface [polypeptide binding]; other site
1400867003917	DNA polymerase V subunit UmuC; Reviewed; Region: umuC; PRK03609
1400867003918	umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700
1400867003919	active site
1400867003920	DNA binding site [nucleotide binding]
1400867003921	Domain of unknown function (DUF4113); Region: DUF4113; pfam13438
1400867003922	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
1400867003923	NMT1-like family; Region: NMT1_2; pfam13379
1400867003924	Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707
1400867003925	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1400867003926	active site
1400867003927	phosphorylation site [posttranslational modification]
1400867003928	intermolecular recognition site; other site
1400867003929	dimerization interface [polypeptide binding]; other site
1400867003930	ANTAR domain; Region: ANTAR; pfam03861
1400867003931	nitrite reductase subunit NirD; Provisional; Region: PRK14989
1400867003932	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1400867003933	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1400867003934	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
1400867003935	Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529
1400867003936	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992
1400867003937	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1400867003938	Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243
1400867003939	Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754
1400867003940	[4Fe-4S] binding site [ion binding]; other site
1400867003941	molybdopterin cofactor binding site; other site
1400867003942	Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791
1400867003943	molybdopterin cofactor binding site; other site
1400867003944	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
1400867003945	molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317
1400867003946	MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503
1400867003947	GTP binding site; other site
1400867003948	Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243
1400867003949	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
1400867003950	molybdopterin cofactor binding site; other site
1400867003951	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
1400867003952	The MopB_CT_1 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. This CD is of the...; Region: MopB_CT_1; cd02782
1400867003953	putative molybdopterin cofactor binding site; other site
1400867003954	molybdenum cofactor biosynthesis protein A, bacterial; Region: moaA; TIGR02666
1400867003955	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1400867003956	FeS/SAM binding site; other site
1400867003957	Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463
1400867003958	MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756
1400867003959	MoaE homodimer interface [polypeptide binding]; other site
1400867003960	MoaD interaction [polypeptide binding]; other site
1400867003961	active site residues [active]
1400867003962	bifunctional molybdenum cofactor biosynthesis protein MoaC/MogA; Provisional; Region: moaC; PRK03604
1400867003963	MoaC family. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine derivative to the precursor...; Region: MoaC; cl00242
1400867003964	trimer interface [polypeptide binding]; other site
1400867003965	dimer interface [polypeptide binding]; other site
1400867003966	putative active site [active]
1400867003967	MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886
1400867003968	MPT binding site; other site
1400867003969	trimer interface [polypeptide binding]; other site
1400867003970	Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303
1400867003971	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
1400867003972	dimer interface [polypeptide binding]; other site
1400867003973	putative functional site; other site
1400867003974	putative MPT binding site; other site
1400867003975	Predicted transcriptional regulators [Transcription]; Region: COG1733
1400867003976	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
1400867003977	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1400867003978	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
1400867003979	DNA-binding site [nucleotide binding]; DNA binding site
1400867003980	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1400867003981	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1400867003982	homodimer interface [polypeptide binding]; other site
1400867003983	catalytic residue [active]
1400867003984	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
1400867003985	EamA-like transporter family; Region: EamA; pfam00892
1400867003986	EamA-like transporter family; Region: EamA; pfam00892
1400867003987	Dissimilatory sulfite reductase (desulfoviridin), gamma subunit [Inorganic ion transport and metabolism]; Region: DsrC; COG2920
1400867003988	DsrC like protein; Region: DsrC; pfam04358
1400867003989	sulfur relay protein TusD/DsrE; Region: sulf_tusD_dsrE; TIGR03012
1400867003990	UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087
1400867003991	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1400867003992	NAD(P) binding site [chemical binding]; other site
1400867003993	active site
1400867003994	fumarate hydratase; Reviewed; Region: fumC; PRK00485
1400867003995	Class II fumarases; Region: Fumarase_classII; cd01362
1400867003996	active site
1400867003997	tetramer interface [polypeptide binding]; other site
1400867003998	D-amino acid dehydrogenase small subunit; Provisional; Region: PRK12409
1400867003999	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
1400867004000	hydroxyglutarate oxidase; Provisional; Region: PRK11728
1400867004001	MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554
1400867004002	homotrimer interaction site [polypeptide binding]; other site
1400867004003	zinc binding site [ion binding]; other site
1400867004004	CDP-binding sites; other site
1400867004005	Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053
1400867004006	ornithine carbamoyltransferase; Provisional; Region: PRK00779
1400867004007	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
1400867004008	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
1400867004009	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1400867004010	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1400867004011	nitrogen regulation protein NR(I); Region: ntrC; TIGR01818
1400867004012	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1400867004013	active site
1400867004014	phosphorylation site [posttranslational modification]
1400867004015	intermolecular recognition site; other site
1400867004016	dimerization interface [polypeptide binding]; other site
1400867004017	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1400867004018	Walker A motif; other site
1400867004019	ATP binding site [chemical binding]; other site
1400867004020	Walker B motif; other site
1400867004021	arginine finger; other site
1400867004022	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
1400867004023	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
1400867004024	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1400867004025	putative active site [active]
1400867004026	heme pocket [chemical binding]; other site
1400867004027	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1400867004028	dimer interface [polypeptide binding]; other site
1400867004029	phosphorylation site [posttranslational modification]
1400867004030	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1400867004031	ATP binding site [chemical binding]; other site
1400867004032	Mg2+ binding site [ion binding]; other site
1400867004033	G-X-G motif; other site
1400867004034	ribosomal protein S12 methylthiotransferase; Provisional; Region: rimO; PRK14862
1400867004035	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
1400867004036	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1400867004037	FeS/SAM binding site; other site
1400867004038	UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254
1400867004039	putative nucleotide binding site [chemical binding]; other site
1400867004040	uridine monophosphate binding site [chemical binding]; other site
1400867004041	homohexameric interface [polypeptide binding]; other site
1400867004042	ribosome recycling factor; Reviewed; Region: frr; PRK00083
1400867004043	Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation.  Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520
1400867004044	hinge region; other site
1400867004045	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230
1400867004046	Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255
1400867004047	catalytic residue [active]
1400867004048	putative FPP diphosphate  binding site; other site
1400867004049	putative FPP binding hydrophobic cleft; other site
1400867004050	dimer interface [polypeptide binding]; other site
1400867004051	putative IPP diphosphate binding site; other site
1400867004052	Cytidylyltransferase family; Region: CTP_transf_1; pfam01148
1400867004053	CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575
1400867004054	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447
1400867004055	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670
1400867004056	1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436
1400867004057	DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288
1400867004058	zinc metallopeptidase RseP; Provisional; Region: PRK10779
1400867004059	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
1400867004060	active site
1400867004061	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
1400867004062	protein binding site [polypeptide binding]; other site
1400867004063	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
1400867004064	protein binding site [polypeptide binding]; other site
1400867004065	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
1400867004066	putative substrate binding region [chemical binding]; other site
1400867004067	outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303
1400867004068	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
1400867004069	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
1400867004070	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
1400867004071	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
1400867004072	Surface antigen; Region: Bac_surface_Ag; pfam01103
1400867004073	Outer membrane protein (OmpH-like); Region: OmpH; pfam03938
1400867004074	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892
1400867004075	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613
1400867004076	UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352
1400867004077	trimer interface [polypeptide binding]; other site
1400867004078	active site
1400867004079	UDP-GlcNAc binding site [chemical binding]; other site
1400867004080	lipid binding site [chemical binding]; lipid-binding site
1400867004081	FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288
1400867004082	UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289
1400867004083	UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351
1400867004084	active site
1400867004085	tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795
1400867004086	recombination regulator RecX; Reviewed; Region: recX; PRK00117
1400867004087	recombinase A; Provisional; Region: recA; PRK09354
1400867004088	RecA is a  bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response.  RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983
1400867004089	hexamer interface [polypeptide binding]; other site
1400867004090	Walker A motif; other site
1400867004091	ATP binding site [chemical binding]; other site
1400867004092	Walker B motif; other site
1400867004093	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1400867004094	RNA binding surface [nucleotide binding]; other site
1400867004095	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915
1400867004096	Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419
1400867004097	motif II; other site
1400867004098	Fels-1 Prophage Protein-like; Region: Fels1; pfam05666
1400867004099	Fels-1 Prophage Protein-like; Region: Fels1; pfam05666
1400867004100	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
1400867004101	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
1400867004102	helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344
1400867004103	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1400867004104	putative DNA binding site [nucleotide binding]; other site
1400867004105	putative Zn2+ binding site [ion binding]; other site
1400867004106	AsnC family; Region: AsnC_trans_reg; pfam01037
1400867004107	Kynureninase [Amino acid transport and metabolism]; Region: COG3844
1400867004108	kynureninase; Region: kynureninase; TIGR01814
1400867004109	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1400867004110	catalytic residue [active]
1400867004111	Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113
1400867004112	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
1400867004113	Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922
1400867004114	Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404
1400867004115	Peptidase S8 family domain in ProteinaseK-like proteins; Region: Peptidases_S8_PCSK9_ProteinaseK_like; cd04077
1400867004116	calcium binding site 2 [ion binding]; other site
1400867004117	active site
1400867004118	catalytic triad [active]
1400867004119	calcium binding site 1 [ion binding]; other site
1400867004120	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
1400867004121	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
1400867004122	Sulfate transporter family; Region: Sulfate_transp; pfam00916
1400867004123	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
1400867004124	Uncharacterized ACR, COG2135; Region: DUF159; pfam02586
1400867004125	dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606
1400867004126	Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995
1400867004127	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
1400867004128	Ligand Binding Site [chemical binding]; other site
1400867004129	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1400867004130	PAS domain; Region: PAS_9; pfam13426
1400867004131	putative active site [active]
1400867004132	heme pocket [chemical binding]; other site
1400867004133	PAS fold; Region: PAS_4; pfam08448
1400867004134	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
1400867004135	putative active site [active]
1400867004136	heme pocket [chemical binding]; other site
1400867004137	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1400867004138	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1400867004139	metal binding site [ion binding]; metal-binding site
1400867004140	active site
1400867004141	I-site; other site
1400867004142	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
1400867004143	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1400867004144	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1400867004145	putative DNA binding site [nucleotide binding]; other site
1400867004146	putative Zn2+ binding site [ion binding]; other site
1400867004147	PTS system fructose-specific transporter subunits IIBC; Provisional; Region: PRK10712
1400867004148	PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569
1400867004149	active site
1400867004150	P-loop; other site
1400867004151	phosphorylation site [posttranslational modification]
1400867004152	PTS system, fructose subfamily, IIC component; Region: PTS_IIC_fructo; TIGR01427
1400867004153	Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105
1400867004154	1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164
1400867004155	putative substrate binding site [chemical binding]; other site
1400867004156	putative ATP binding site [chemical binding]; other site
1400867004157	bifunctional PTS system fructose-specific transporter subunit IIA/HPr protein; Provisional; Region: PRK11109
1400867004158	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
1400867004159	active site
1400867004160	phosphorylation site [posttranslational modification]
1400867004161	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cl00163
1400867004162	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
1400867004163	dimerization domain swap beta strand [polypeptide binding]; other site
1400867004164	regulatory protein interface [polypeptide binding]; other site
1400867004165	active site
1400867004166	regulatory phosphorylation site [posttranslational modification]; other site
1400867004167	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
1400867004168	Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080
1400867004169	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
1400867004170	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
1400867004171	Predicted alpha/beta hydrolase [General function prediction only]; Region: COG4757
1400867004172	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
1400867004173	Uncharacterized protein, possibly involved in utilization of glycolate and propanediol [General function prediction only]; Region: GlcG; COG3193
1400867004174	Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547
1400867004175	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
1400867004176	active site
1400867004177	LysR family transcriptional regulator; Provisional; Region: PRK14997
1400867004178	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1400867004179	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_4; cd08473
1400867004180	putative effector binding pocket; other site
1400867004181	putative dimerization interface [polypeptide binding]; other site
1400867004182	replication factor-a protein 1 (rpa1); Region: rpa1; TIGR00617
1400867004183	Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028
1400867004184	putative GSH binding site [chemical binding]; other site
1400867004185	catalytic residues [active]
1400867004186	acetylornithine aminotransferase; Provisional; Region: PRK02627
1400867004187	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
1400867004188	inhibitor-cofactor binding pocket; inhibition site
1400867004189	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1400867004190	catalytic residue [active]
1400867004191	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_10; cd04623
1400867004192	FOG: CBS domain [General function prediction only]; Region: COG0517
1400867004193	Protein of unknown function (DUF2750); Region: DUF2750; pfam11042
1400867004194	signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416
1400867004195	SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881
1400867004196	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
1400867004197	P loop; other site
1400867004198	GTP binding site [chemical binding]; other site
1400867004199	Nitroreductase-like family 4.  A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_4; cd02140
1400867004200	dimer interface [polypeptide binding]; other site
1400867004201	FMN binding site [chemical binding]; other site
1400867004202	Uncharacterized protein conserved in bacteria (DUF2057); Region: DUF2057; pfam09829
1400867004203	Cyd operon protein YbgE (Cyd_oper_YbgE); Region: Cyd_oper_YbgE; pfam09600
1400867004204	Membrane bound YbgT-like protein; Region: YbgT_YccB; pfam08173
1400867004205	cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219
1400867004206	Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322
1400867004207	cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097
1400867004208	Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562
1400867004209	Protein of unknown function (DUF1449); Region: DUF1449; pfam07290
1400867004210	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467
1400867004211	iron-sulfur cluster [ion binding]; other site
1400867004212	[2Fe-2S] cluster binding site [ion binding]; other site
1400867004213	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
1400867004214	Adenosine kinase (AK) catalyzes the phosphorylation of ribofuranosyl-containing nucleoside analogues at the 5'-hydroxyl using ATP or GTP as the phosphate donor.The physiological function of AK is associated with the regulation of extracellular...; Region: adenosine_kinase; cd01168
1400867004215	substrate binding site [chemical binding]; other site
1400867004216	ATP binding site [chemical binding]; other site
1400867004217	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
1400867004218	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
1400867004219	N-terminal plug; other site
1400867004220	ligand-binding site [chemical binding]; other site
1400867004221	Predicted Zn-dependent peptidases, insulinase-like [General function prediction only]; Region: COG1026
1400867004222	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
1400867004223	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
1400867004224	Peptidase M16C associated; Region: M16C_assoc; pfam08367
1400867004225	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
1400867004226	The outer membrane phospholipase A (OMPLA) is an integral membrane enzyme that catalyses the hydrolysis of acylester bonds in phospholipids using calcium as a cofactor. The enzyme has a fold of transmembrane beta-barrels and is widespread among...; Region: OMPLA; cd00541
1400867004227	dimerization interface [polypeptide binding]; other site
1400867004228	substrate binding site [chemical binding]; other site
1400867004229	active site
1400867004230	calcium binding site [ion binding]; other site
1400867004231	Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168
1400867004232	potassium uptake protein, TrkH family; Region: 2a38; TIGR00933
1400867004233	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
1400867004234	TrkA-N domain; Region: TrkA_N; pfam02254
1400867004235	threonine dehydratase; Reviewed; Region: PRK09224
1400867004236	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
1400867004237	tetramer interface [polypeptide binding]; other site
1400867004238	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1400867004239	catalytic residue [active]
1400867004240	First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906
1400867004241	putative Ile/Val binding site [chemical binding]; other site
1400867004242	Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907
1400867004243	putative Ile/Val binding site [chemical binding]; other site
1400867004244	RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398
1400867004245	tetramer (dimer of dimers) interface [polypeptide binding]; other site
1400867004246	active site
1400867004247	dimer interface [polypeptide binding]; other site
1400867004248	Protein of unknown function DUF45; Region: DUF45; pfam01863
1400867004249	N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436
1400867004250	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
1400867004251	Uncharacterized conserved protein [Function unknown]; Region: COG2127
1400867004252	ATP-dependent Clp protease ATP-binding subunit clpA; Region: ClpA; TIGR02639
1400867004253	Clp amino terminal domain; Region: Clp_N; pfam02861
1400867004254	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1400867004255	Walker A motif; other site
1400867004256	ATP binding site [chemical binding]; other site
1400867004257	Walker B motif; other site
1400867004258	arginine finger; other site
1400867004259	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1400867004260	Walker A motif; other site
1400867004261	ATP binding site [chemical binding]; other site
1400867004262	Walker B motif; other site
1400867004263	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
1400867004264	hypothetical protein; Provisional; Region: PRK02237
1400867004265	phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12755
1400867004266	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
1400867004267	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
1400867004268	Predicted transcriptional regulators [Transcription]; Region: COG1695
1400867004269	Transcriptional regulator PadR-like family; Region: PadR; cl17335
1400867004270	Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400
1400867004271	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
1400867004272	2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli  is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930
1400867004273	active site
1400867004274	FMN binding site [chemical binding]; other site
1400867004275	2,4-decadienoyl-CoA binding site; other site
1400867004276	catalytic residue [active]
1400867004277	4Fe-4S cluster binding site [ion binding]; other site
1400867004278	Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446
1400867004279	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1400867004280	SnoaL-like domain; Region: SnoaL_2; pfam12680
1400867004281	SGNH_hydrolase subfamily, FeeA, FeeB and similar esterases/lipases. FeeA and FeeB are part of a biosynthetic gene cluster and may participate in the biosynthesis of long-chain N-acyltyrosines by providing saturated and unsaturated fatty acids, which it...; Region: FeeA_FeeB_like; cd01836
1400867004282	active site
1400867004283	catalytic triad [active]
1400867004284	oxyanion hole [active]
1400867004285	Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; Region: COG0429
1400867004286	Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687
1400867004287	Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118
1400867004288	CTP synthetase; Validated; Region: pyrG; PRK05380
1400867004289	CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113
1400867004290	Catalytic site [active]
1400867004291	active site
1400867004292	UTP binding site [chemical binding]; other site
1400867004293	Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746
1400867004294	active site
1400867004295	putative oxyanion hole; other site
1400867004296	catalytic triad [active]
1400867004297	2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198
1400867004298	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
1400867004299	enolase; Provisional; Region: eno; PRK00077
1400867004300	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
1400867004301	dimer interface [polypeptide binding]; other site
1400867004302	metal binding site [ion binding]; metal-binding site
1400867004303	substrate binding pocket [chemical binding]; other site
1400867004304	Predicted membrane protein [Function unknown]; Region: COG2323
1400867004305	Septum formation initiator; Region: DivIC; cl17659
1400867004306	Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919
1400867004307	CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516
1400867004308	substrate binding site; other site
1400867004309	dimer interface; other site
1400867004310	Coenzyme A transferase; Region: CoA_trans; cl17247
1400867004311	Coenzyme A transferase; Region: CoA_trans; cl17247
1400867004312	Coenzyme A transferase; Region: CoA_trans; cl17247
1400867004313	Coenzyme A transferase; Region: CoA_trans; cl17247
1400867004314	beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050
1400867004315	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
1400867004316	dimer interface [polypeptide binding]; other site
1400867004317	active site
1400867004318	3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427
1400867004319	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
1400867004320	The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid.  N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467
1400867004321	The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid.  N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467
1400867004322	active site
1400867004323	Escherichia coli NAD+-dependent phenylacetaldehyde dehydrogenase PadA-like; Region: ALDH_PADH_NahF; cd07113
1400867004324	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
1400867004325	NAD(P) binding site [chemical binding]; other site
1400867004326	catalytic residues [active]
1400867004327	tyramine oxidase; Provisional; Region: tynA; PRK14696
1400867004328	Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833
1400867004329	Copper amine oxidase, N3 domain; Region: Cu_amine_oxidN3; pfam02728
1400867004330	Copper amine oxidase, enzyme domain; Region: Cu_amine_oxid; pfam01179
1400867004331	DNA-binding transcriptional activator FeaR; Provisional; Region: PRK09685
1400867004332	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1400867004333	Flavin reductase like domain; Region: Flavin_Reduct; smart00903
1400867004334	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
1400867004335	Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal  ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185
1400867004336	FMN-binding pocket [chemical binding]; other site
1400867004337	flavin binding motif; other site
1400867004338	phosphate binding motif [ion binding]; other site
1400867004339	beta-alpha-beta structure motif; other site
1400867004340	NAD binding pocket [chemical binding]; other site
1400867004341	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
1400867004342	catalytic loop [active]
1400867004343	iron binding site [ion binding]; other site
1400867004344	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
1400867004345	classical (c) SDRs; Region: SDR_c; cd05233
1400867004346	NAD(P) binding site [chemical binding]; other site
1400867004347	active site
1400867004348	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
1400867004349	benzoate 1,2-dioxygenase, large subunit; Region: benzo_1_2_benA; TIGR03229
1400867004350	Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469
1400867004351	[2Fe-2S] cluster binding site [ion binding]; other site
1400867004352	C-terminal catalytic domain of the oxygenase alpha subunit of Pseudomonas resinovorans strain CA10 anthranilate 1,2-dioxygenase and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_AntDO-like; cd08879
1400867004353	putative alpha subunit interface [polypeptide binding]; other site
1400867004354	putative active site [active]
1400867004355	putative substrate binding site [chemical binding]; other site
1400867004356	Fe binding site [ion binding]; other site
1400867004357	SnoaL-like domain; Region: SnoaL_4; pfam13577
1400867004358	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
1400867004359	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
1400867004360	active site
1400867004361	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
1400867004362	Amidase; Region: Amidase; cl11426
1400867004363	Transcriptional regulators [Transcription]; Region: MarR; COG1846
1400867004364	Winged helix DNA-binding domain; Region: HTH_27; pfam13463
1400867004365	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1400867004366	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1400867004367	putative substrate translocation pore; other site
1400867004368	outer membrane porin, OprD family; Region: OprD; pfam03573
1400867004369	short chain dehydrogenase; Provisional; Region: PRK08251
1400867004370	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1400867004371	NAD(P) binding site [chemical binding]; other site
1400867004372	active site
1400867004373	Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040
1400867004374	catalytic core [active]
1400867004375	thiamine kinase; Region: ycfN_thiK; TIGR02721
1400867004376	Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154
1400867004377	putative active site [active]
1400867004378	putative substrate binding site [chemical binding]; other site
1400867004379	ATP binding site [chemical binding]; other site
1400867004380	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
1400867004381	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
1400867004382	active site
1400867004383	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1400867004384	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1400867004385	The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417
1400867004386	substrate binding pocket [chemical binding]; other site
1400867004387	dimerization interface [polypeptide binding]; other site
1400867004388	beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Region: pcaR_pcaU; TIGR02431
1400867004389	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
1400867004390	Bacterial transcriptional regulator; Region: IclR; pfam01614
1400867004391	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
1400867004392	Domain of unknown function (DUF4341); Region: DUF4341; pfam14241
1400867004393	Predicted transporter component [General function prediction only]; Region: COG2391
1400867004394	Sulphur transport; Region: Sulf_transp; pfam04143
1400867004395	7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695
1400867004396	membrane-bound PQQ-dependent dehydrogenase, glucose/quinate/shikimate family; Region: PQQ_membr_DH; TIGR03074
1400867004397	Membrane-bound PQQ-dependent glucose dehydrogenase; Region: PQQ_mGDH; cd10280
1400867004398	Trp docking motif [polypeptide binding]; other site
1400867004399	putative active site [active]
1400867004400	Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966
1400867004401	Right handed beta helix region; Region: Beta_helix; pfam13229
1400867004402	Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502
1400867004403	3-dehydroquinate dehydratase [Amino acid transport and metabolism]; Region: AroD; COG0710
1400867004404	active site
1400867004405	catalytic residue [active]
1400867004406	dimer interface [polypeptide binding]; other site
1400867004407	Protocatechuate 3,4-dioxygenase beta subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PcaH; COG3485
1400867004408	Protocatechuate 3,4-dioxygenase (3,4-PCD) , alpha subunit. 3,4-PCD catalyzes the oxidative ring cleavage of 3,4-dihydroxybenzoate to produce beta-carboxy-cis,cis-muconate. 3,4-PCDs are large aggregates of 12 protomers, each composed of an alpha- and...; Region: 3,4-PCD_alpha; cd03463
1400867004409	heterodimer interface [polypeptide binding]; other site
1400867004410	active site
1400867004411	Protocatechuate 3,4-dioxygenase (3,4-PCD) , beta subunit. 3,4-PCD catalyzes the oxidative ring cleavage of 3,4-dihydroxybenzoate to produce beta-carboxy-cis,cis-muconate. 3,4-PCDs are large aggregates of 12 protomers, each composed of an alpha- and...; Region: 3,4-PCD_beta; cd03464
1400867004412	heterodimer interface [polypeptide binding]; other site
1400867004413	multimer interface [polypeptide binding]; other site
1400867004414	protocatechuate 3,4-dioxygenase, beta subunit; Region: protocat_beta; TIGR02422
1400867004415	active site
1400867004416	Carboxymuconolactone decarboxylase family; Region: CMD; cl00460
1400867004417	benzoate transport; Region: 2A0115; TIGR00895
1400867004418	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1400867004419	putative substrate translocation pore; other site
1400867004420	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1400867004421	3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427
1400867004422	3-carboxy-cis,cis-muconate cycloisomerase; Provisional; Region: PRK09053
1400867004423	prokaryotic 3-carboxy-cis,cis-muconate cycloisomerase (CMLE)_like; Region: pCLME; cd01597
1400867004424	tetramer interface [polypeptide binding]; other site
1400867004425	active site
1400867004426	beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050
1400867004427	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
1400867004428	dimer interface [polypeptide binding]; other site
1400867004429	active site
1400867004430	3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428
1400867004431	3-oxoacid CoA-transferase, A subunit; Region: pcaI_scoA_fam; TIGR02429
1400867004432	catechol 1,2-dioxygenase, proteobacterial; Region: catechol_proteo; TIGR02439
1400867004433	Catechol 1,2 dioxygenase (1,2-CTD) catalyzes an intradiol cleavage reaction of catechol to form cis,cis-muconate. 1,2-CTDs is homodimers with one catalytic non-heme ferric ion per monomer. They belong to the aromatic dioxygenase family, a family of...; Region: 1,2-CTD; cd03460
1400867004434	dimer interface [polypeptide binding]; other site
1400867004435	active site
1400867004436	muconolactone delta-isomerase; Region: muco_delta; TIGR03221
1400867004437	muconate and chloromuconate cycloisomerases; Region: mucon_cyclo; TIGR02534
1400867004438	Muconate Lactonizing Enzyme (MLE), an homooctameric enzyme, catalyses the conversion of cis,cis-muconate (CCM) to muconolactone (ML) in the catechol branch of the beta-ketoadipate pathway. This pathway is used in soil microbes to breakdown lignin-derived...; Region: MLE; cd03318
1400867004439	octamer interface [polypeptide binding]; other site
1400867004440	active site
1400867004441	DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906
1400867004442	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1400867004443	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1400867004444	dimerization interface [polypeptide binding]; other site
1400867004445	Bacterial protein of unknown function (Gcw_chp); Region: Gcw_chp; cl09901
1400867004446	Transcriptional regulators [Transcription]; Region: FadR; COG2186
1400867004447	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1400867004448	DNA-binding site [nucleotide binding]; DNA binding site
1400867004449	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
1400867004450	dihydroxy-acid dehydratase; Validated; Region: PRK06131
1400867004451	4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332
1400867004452	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1400867004453	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1400867004454	Uncharacterized protein conserved in bacteria [Function unknown]; Region: GguC; COG3802
1400867004455	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
1400867004456	NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012
1400867004457	Alpha-Ketoglutaric Semialdehyde Dehydrogenase; Region: ALDH_KGSADH; cd07129
1400867004458	dimer interface [polypeptide binding]; other site
1400867004459	NADP binding site [chemical binding]; other site
1400867004460	catalytic residues [active]
1400867004461	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
1400867004462	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
1400867004463	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
1400867004464	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
1400867004465	Old yellow enzyme (OYE)-related FMN binding domain, group 2.  Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_2_FMN; cd04733
1400867004466	putative active site [active]
1400867004467	putative FMN binding site [chemical binding]; other site
1400867004468	putative substrate binding site [chemical binding]; other site
1400867004469	putative catalytic residue [active]
1400867004470	Uncharacterized conserved protein [Function unknown]; Region: COG3268
1400867004471	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1400867004472	NAD(P) binding site [chemical binding]; other site
1400867004473	Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141
1400867004474	Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693
1400867004475	potential catalytic triad [active]
1400867004476	conserved cys residue [active]
1400867004477	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
1400867004478	Cu(I)-responsive transcriptional regulator; Region: CueR; TIGR02044
1400867004479	DNA binding residues [nucleotide binding]
1400867004480	Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693
1400867004481	Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141
1400867004482	potential catalytic triad [active]
1400867004483	conserved cys residue [active]
1400867004484	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
1400867004485	Transcriptional regulator; Region: Rrf2; pfam02082
1400867004486	Rrf2 family protein; Region: rrf2_super; TIGR00738
1400867004487	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
1400867004488	Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706
1400867004489	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1400867004490	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1400867004491	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1400867004492	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1400867004493	The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417
1400867004494	substrate binding pocket [chemical binding]; other site
1400867004495	dimerization interface [polypeptide binding]; other site
1400867004496	short chain dehydrogenase; Provisional; Region: PRK07035
1400867004497	classical (c) SDRs; Region: SDR_c; cd05233
1400867004498	NAD(P) binding site [chemical binding]; other site
1400867004499	active site
1400867004500	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231
1400867004501	classical (c) SDRs; Region: SDR_c; cd05233
1400867004502	NAD(P) binding site [chemical binding]; other site
1400867004503	active site
1400867004504	(3R)-hydroxyacyl-CoA dehydrogenase-like, classical(c)-like SDRs; Region: hydroxyacyl-CoA-like_DH_SDR_c-like; cd05353
1400867004505	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK12825
1400867004506	NAD binding site [chemical binding]; other site
1400867004507	homodimer interface [polypeptide binding]; other site
1400867004508	active site
1400867004509	NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit.  Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450
1400867004510	putative active site [active]
1400867004511	putative catalytic site [active]
1400867004512	acyl-CoA dehydrogenase; Provisional; Region: PTZ00456
1400867004513	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
1400867004514	active site
1400867004515	Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806
1400867004516	Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; cl17479
1400867004517	Long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07059
1400867004518	Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936
1400867004519	acyl-activating enzyme (AAE) consensus motif; other site
1400867004520	putative AMP binding site [chemical binding]; other site
1400867004521	putative active site [active]
1400867004522	putative CoA binding site [chemical binding]; other site
1400867004523	bile acid transporter; Region: bass; TIGR00841
1400867004524	Sodium Bile acid symporter family; Region: SBF; pfam01758
1400867004525	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1400867004526	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1400867004527	POTRA domain, ShlB-type; Region: POTRA_2; pfam08479
1400867004528	Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831
1400867004529	Haemolysin secretion/activation protein ShlB/FhaC/HecB; Region: ShlB; pfam03865
1400867004530	haemagglutination activity domain; Region: Haemagg_act; pfam05860
1400867004531	Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332
1400867004532	Possible hemagglutinin (DUF637); Region: DUF637; pfam04830
1400867004533	Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081
1400867004534	protein-splicing catalytic site; other site
1400867004535	thioester formation/cholesterol transfer; other site
1400867004536	Pretoxin HINT domain; Region: PT-HINT; pfam07591
1400867004537	Protein of unknown function (DUF1347); Region: DUF1347; pfam07079
1400867004538	4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332
1400867004539	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1400867004540	putative substrate translocation pore; other site
1400867004541	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1400867004542	Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618
1400867004543	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
1400867004544	active site
1400867004545	Dicarboxylate carrier protein MatC N-terminus; Region: MatC_N; pfam07158
1400867004546	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
1400867004547	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221
1400867004548	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
1400867004549	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1400867004550	DNA-binding site [nucleotide binding]; DNA binding site
1400867004551	The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866
1400867004552	SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450
1400867004553	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567
1400867004554	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1400867004555	putative substrate translocation pore; other site
1400867004556	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1400867004557	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1400867004558	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1400867004559	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
1400867004560	putative effector binding pocket; other site
1400867004561	dimerization interface [polypeptide binding]; other site
1400867004562	Protein of unknown function, DUF606; Region: DUF606; pfam04657
1400867004563	Protein of unknown function, DUF606; Region: DUF606; pfam04657
1400867004564	IclR helix-turn-helix domain; Region: HTH_IclR; cl17605
1400867004565	Bacterial transcriptional regulator; Region: IclR; pfam01614
1400867004566	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1400867004567	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1400867004568	putative substrate translocation pore; other site
1400867004569	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
1400867004570	Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173
1400867004571	ligand binding site [chemical binding]; other site
1400867004572	NAD binding site [chemical binding]; other site
1400867004573	dimerization interface [polypeptide binding]; other site
1400867004574	catalytic site [active]
1400867004575	hypothetical protein; Validated; Region: PRK06201
1400867004576	Demethylmenaquinone methyltransferase [Coenzyme metabolism]; Region: MenG; COG0684
1400867004577	Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566
1400867004578	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
1400867004579	HlyD family secretion protein; Region: HlyD_3; pfam13437
1400867004580	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1400867004581	putative substrate translocation pore; other site
1400867004582	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1400867004583	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1400867004584	AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246
1400867004585	Helix-turn-helix domain; Region: HTH_18; pfam12833
1400867004586	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1400867004587	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
1400867004588	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
1400867004589	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1400867004590	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1400867004591	DNA binding residues [nucleotide binding]
1400867004592	dimerization interface [polypeptide binding]; other site
1400867004593	Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076
1400867004594	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
1400867004595	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
1400867004596	Amino acid permease; Region: AA_permease_2; pfam13520
1400867004597	Bacterial protein of unknown function (Gcw_chp); Region: Gcw_chp; cl09901
1400867004598	Protein of unknown function (DUF861); Region: Cupin_3; cl17594
1400867004599	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
1400867004600	Streptomyces aureofaciens putative aldehyde dehydrogenase AldA (AAD23400)-like; Region: ALDH_AldA-AAD23400; cd07106
1400867004601	NAD(P) binding site [chemical binding]; other site
1400867004602	catalytic residues [active]
1400867004603	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
1400867004604	tyrosyl-tRNA synthetase; Validated; Region: PRK05912
1400867004605	catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805
1400867004606	active site
1400867004607	HIGH motif; other site
1400867004608	dimer interface [polypeptide binding]; other site
1400867004609	KMSKS motif; other site
1400867004610	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1400867004611	bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102
1400867004612	putative substrate translocation pore; other site
1400867004613	4-hydroxyphenylacetate catabolism regulatory protein HpaA; Region: HpaA; TIGR02297
1400867004614	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
1400867004615	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1400867004616	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421
1400867004617	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
1400867004618	4-hydroxyphenylacetate degradation bifunctional isomerase/decarboxylase, C-terminal subunit; Region: HpaG-C-term; TIGR02303
1400867004619	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
1400867004620	5-carboxymethyl-2-hydroxymuconate semialdehyde dehydrogenase; Region: HpaE; TIGR02299
1400867004621	Human aldehyde dehydrogenase family 8 member A1-like; Region: ALDH_F8_HMSADH; cd07093
1400867004622	NAD binding site [chemical binding]; other site
1400867004623	catalytic residues [active]
1400867004624	The Class III extradiol dioxygenase, homoprotocatechuate 2,3-dioxygenase, catalyzes the key ring cleavage step in the metabolism of homoprotocatechuate; Region: HPCD; cd07370
1400867004625	Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900
1400867004626	putative active site [active]
1400867004627	putative metal binding site [ion binding]; other site
1400867004628	5-carboxymethyl-2-hydroxymuconate isomerase (CHMI) is a trimeric enzyme catalyzing the isomerization of the unsaturated ketone 5-(carboxymethyl)-2-hydroxymuconate to 5-(carboxymethyl)-2-oxo-3-hexene-1,6-dionate. This is one step in the...; Region: CHMI; cd00580
1400867004629	putative substrate binding pocket [chemical binding]; other site
1400867004630	trimer interface [polypeptide binding]; other site
1400867004631	2-oxo-hepta-3-ene-1,7-dioic acid hydratase; Region: HpaH; TIGR02312
1400867004632	HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231
1400867004633	succinic semialdehyde dehydrogenase; Region: PLN02278
1400867004634	Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103
1400867004635	tetramerization interface [polypeptide binding]; other site
1400867004636	NAD(P) binding site [chemical binding]; other site
1400867004637	catalytic residues [active]
1400867004638	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1400867004639	metabolite-proton symporter; Region: 2A0106; TIGR00883
1400867004640	putative substrate translocation pore; other site
1400867004641	Naphthocyclinone hydroxylase; Region: NcnH; cd01159
1400867004642	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
1400867004643	Flavin binding site [chemical binding]; other site
1400867004644	Flavin reductase like domain; Region: Flavin_Reduct; smart00903
1400867004645	MarR family; Region: MarR_2; cl17246
1400867004646	NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012
1400867004647	Alpha-Ketoglutaric Semialdehyde Dehydrogenase; Region: ALDH_KGSADH; cd07129
1400867004648	dimer interface [polypeptide binding]; other site
1400867004649	NADP binding site [chemical binding]; other site
1400867004650	catalytic residues [active]
1400867004651	dihydroxy-acid dehydratase; Provisional; Region: PRK13017
1400867004652	Fumarylacetoacetate (FAA) hydrolase family protein [General function prediction only]; Region: COG3970
1400867004653	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
1400867004654	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1400867004655	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1400867004656	The C-terminal substrate binding domain of galactose-binding protein regulator contains the type 2 periplasmic binding fold; Region: PBP2_GbpR; cd08435
1400867004657	putative dimerization interface [polypeptide binding]; other site
1400867004658	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
1400867004659	Escherichia coli Gne (a nucleoside-diphosphate-sugar 4-epimerase)-like, extended (e) SDRs; Region: Gne_like_SDR_e; cd05238
1400867004660	putative NAD(P) binding site [chemical binding]; other site
1400867004661	active site
1400867004662	putative substrate binding site [chemical binding]; other site
1400867004663	4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332
1400867004664	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1400867004665	putative substrate translocation pore; other site
1400867004666	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
1400867004667	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
1400867004668	AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719
1400867004669	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
1400867004670	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1400867004671	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1400867004672	Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917
1400867004673	Carboxymuconolactone decarboxylase family; Region: CMD; cl00460
1400867004674	Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599
1400867004675	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
1400867004676	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283
1400867004677	putative NAD(P) binding site [chemical binding]; other site
1400867004678	putative substrate binding site [chemical binding]; other site
1400867004679	catalytic Zn binding site [ion binding]; other site
1400867004680	structural Zn binding site [ion binding]; other site
1400867004681	dimer interface [polypeptide binding]; other site
1400867004682	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
1400867004683	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
1400867004684	intersubunit interface [polypeptide binding]; other site
1400867004685	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
1400867004686	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1400867004687	ABC-ATPase subunit  interface; other site
1400867004688	dimer interface [polypeptide binding]; other site
1400867004689	putative PBP binding regions; other site
1400867004690	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
1400867004691	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
1400867004692	Walker A/P-loop; other site
1400867004693	ATP binding site [chemical binding]; other site
1400867004694	Q-loop/lid; other site
1400867004695	ABC transporter signature motif; other site
1400867004696	Walker B; other site
1400867004697	D-loop; other site
1400867004698	H-loop/switch region; other site
1400867004699	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
1400867004700	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1400867004701	Coenzyme A binding pocket [chemical binding]; other site
1400867004702	Cupin domain; Region: Cupin_2; cl17218
1400867004703	Helix-turn-helix domain; Region: HTH_18; pfam12833
1400867004704	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1400867004705	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
1400867004706	Phosphoribosylpyrophosphate synthetase [Nucleotide transport and metabolism / Amino acid transport and metabolism]; Region: PrsA; COG0462
1400867004707	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
1400867004708	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1400867004709	active site
1400867004710	putative nicotinate phosphoribosyltransferase; Provisional; Region: PRK09198
1400867004711	pre-B-cell colony-enhancing factor (PBEF)-like. The mammalian members of this group of nicotinate phosphoribosyltransferases (NAPRTases) were originally identified as genes whose expression is upregulated upon activation in lymphoid cells. In general; Region: PBEF_like; cd01569
1400867004712	active site
1400867004713	ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051
1400867004714	nudix motif; other site
1400867004715	Uncharacterized conserved protein [General function prediction only]; Region: COG4111
1400867004716	Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cl00246
1400867004717	FAD binding site [chemical binding]; other site
1400867004718	Methylene-tetrahydrofolate reductase C terminal; Region: MTHFR_C; pfam12225
1400867004719	Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566
1400867004720	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
1400867004721	HlyD family secretion protein; Region: HlyD_3; pfam13437
1400867004722	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
1400867004723	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1400867004724	putative substrate translocation pore; other site
1400867004725	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1400867004726	GH3 auxin-responsive promoter; Region: GH3; pfam03321
1400867004727	type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844
1400867004728	Survival protein SurE; Region: SurE; pfam01975
1400867004729	HD domain; Region: HD_4; pfam13328
1400867004730	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1400867004731	non-specific DNA binding site [nucleotide binding]; other site
1400867004732	salt bridge; other site
1400867004733	sequence-specific DNA binding site [nucleotide binding]; other site
1400867004734	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1400867004735	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1400867004736	RloB-like protein; Region: RloB; pfam13707
1400867004737	Predicted ATPases [General function prediction only]; Region: COG1106
1400867004738	classical (c) SDRs; Region: SDR_c; cd05233
1400867004739	NAD(P) binding site [chemical binding]; other site
1400867004740	active site
1400867004741	Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028
1400867004742	classical (c) SDRs; Region: SDR_c; cd05233
1400867004743	NAD(P) binding site [chemical binding]; other site
1400867004744	active site
1400867004745	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
1400867004746	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
1400867004747	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
1400867004748	Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625
1400867004749	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220
1400867004750	dimerization interface [polypeptide binding]; other site
1400867004751	putative DNA binding site [nucleotide binding]; other site
1400867004752	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1400867004753	putative Zn2+ binding site [ion binding]; other site
1400867004754	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1400867004755	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1400867004756	dimerization interface [polypeptide binding]; other site
1400867004757	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1400867004758	dimer interface [polypeptide binding]; other site
1400867004759	phosphorylation site [posttranslational modification]
1400867004760	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1400867004761	ATP binding site [chemical binding]; other site
1400867004762	Mg2+ binding site [ion binding]; other site
1400867004763	G-X-G motif; other site
1400867004764	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1400867004765	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1400867004766	active site
1400867004767	phosphorylation site [posttranslational modification]
1400867004768	intermolecular recognition site; other site
1400867004769	dimerization interface [polypeptide binding]; other site
1400867004770	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1400867004771	DNA binding site [nucleotide binding]
1400867004772	multidrug efflux system protein MdtE; Provisional; Region: PRK09859
1400867004773	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
1400867004774	HlyD family secretion protein; Region: HlyD_3; pfam13437
1400867004775	The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915
1400867004776	Protein export membrane protein; Region: SecD_SecF; cl14618
1400867004777	Protein export membrane protein; Region: SecD_SecF; cl14618
1400867004778	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1400867004779	Walker B; other site
1400867004780	D-loop; other site
1400867004781	H-loop/switch region; other site
1400867004782	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1400867004783	AAA domain; Region: AAA_21; pfam13304
1400867004784	Walker A/P-loop; other site
1400867004785	ATP binding site [chemical binding]; other site
1400867004786	Q-loop/lid; other site
1400867004787	ABC transporter signature motif; other site
1400867004788	Walker B; other site
1400867004789	D-loop; other site
1400867004790	H-loop/switch region; other site
1400867004791	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1400867004792	Walker A/P-loop; other site
1400867004793	ATP binding site [chemical binding]; other site
1400867004794	Q-loop/lid; other site
1400867004795	P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539
1400867004796	P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121
1400867004797	Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345
1400867004798	Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753
1400867004799	P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188
1400867004800	PapC N-terminal domain; Region: PapC_N; pfam13954
1400867004801	Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577
1400867004802	PapC C-terminal domain; Region: PapC_C; pfam13953
1400867004803	P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539
1400867004804	class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300
1400867004805	S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase; Region: adh_III_F_hyde; TIGR02818
1400867004806	substrate binding site [chemical binding]; other site
1400867004807	catalytic Zn binding site [ion binding]; other site
1400867004808	NAD binding site [chemical binding]; other site
1400867004809	structural Zn binding site [ion binding]; other site
1400867004810	dimer interface [polypeptide binding]; other site
1400867004811	Catalase-like heme-binding proteins similar to the uncharacterized y4iL; Region: y4iL_like; cd08152
1400867004812	putative heme binding pocket [chemical binding]; other site
1400867004813	Putative catalytic domain, repeat 1, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_1; cd09111
1400867004814	PLD-like domain; Region: PLDc_2; pfam13091
1400867004815	putative active site [active]
1400867004816	catalytic site [active]
1400867004817	Putative catalytic domain, repeat 2, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_2; cd09113
1400867004818	PLD-like domain; Region: PLDc_2; pfam13091
1400867004819	putative active site [active]
1400867004820	catalytic site [active]
1400867004821	MUG-like Uracil-DNA glycosylase enzyme family; Region: UDG_MUG_like; cd10032
1400867004822	putative active site [active]
1400867004823	Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355
1400867004824	renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301
1400867004825	active site
1400867004826	dimer interface [polypeptide binding]; other site
1400867004827	pyrroloquinoline quinone biosynthesis protein PqqE; Provisional; Region: PRK05301
1400867004828	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1400867004829	FeS/SAM binding site; other site
1400867004830	radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085
1400867004831	pyrroloquinoline quinone biosynthesis protein PqqD; Provisional; Region: PRK02079
1400867004832	pyrroloquinoline quinone biosynthesis protein PqqC; Provisional; Region: PRK05157
1400867004833	pyrroloquinoline quinone biosynthesis protein PqqB; Provisional; Region: PRK05184
1400867004834	coenzyme PQQ biosynthesis protein B; Region: PQQ_syn_pqqB; TIGR02108
1400867004835	polyphosphate kinase; Provisional; Region: PRK05443
1400867004836	Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089
1400867004837	Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503
1400867004838	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
1400867004839	putative active site [active]
1400867004840	catalytic site [active]
1400867004841	Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168
1400867004842	putative domain interface [polypeptide binding]; other site
1400867004843	putative active site [active]
1400867004844	catalytic site [active]
1400867004845	5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737
1400867004846	Bacillus subtilis YhcR endonuclease and related proteins, N-terminal metallophosphatase domain; Region: MPP_YhcR_N; cd07412
1400867004847	putative active site [active]
1400867004848	putative metal binding site [ion binding]; other site
1400867004849	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
1400867004850	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cl17326
1400867004851	metal binding site 2 [ion binding]; metal-binding site
1400867004852	putative DNA binding helix; other site
1400867004853	metal binding site 1 [ion binding]; metal-binding site
1400867004854	dimer interface [polypeptide binding]; other site
1400867004855	structural Zn2+ binding site [ion binding]; other site
1400867004856	Isochorismatase, also known as 2,3 dihydro-2,3 dihydroxybenzoate synthase, catalyses the conversion of isochorismate, in the presence of water, to 2,3-dihydroxybenzoate and pyruvate, via the hydrolysis of a vinyl ether, an uncommon reaction in biological...; Region: isochorismatase; cd01013
1400867004857	hydrophobic substrate binding pocket; other site
1400867004858	Isochorismatase family; Region: Isochorismatase; pfam00857
1400867004859	active site
1400867004860	conserved cis-peptide bond; other site
1400867004861	2,3-dihydroxybenzoate-2,3-dehydrogenase; Validated; Region: PRK08220
1400867004862	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1400867004863	NAD(P) binding site [chemical binding]; other site
1400867004864	active site
1400867004865	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1400867004866	Walker A/P-loop; other site
1400867004867	ATP binding site [chemical binding]; other site
1400867004868	Q-loop/lid; other site
1400867004869	ABC transporter signature motif; other site
1400867004870	Walker B; other site
1400867004871	D-loop; other site
1400867004872	H-loop/switch region; other site
1400867004873	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
1400867004874	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1400867004875	dimer interface [polypeptide binding]; other site
1400867004876	conserved gate region; other site
1400867004877	putative PBP binding loops; other site
1400867004878	ABC-ATPase subunit interface; other site
1400867004879	molybdate transporter periplasmic protein; Provisional; Region: modA; PRK10677
1400867004880	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
1400867004881	N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; cl17549
1400867004882	anthranilate 1,2-dioxygenase, large subunit; Region: anthran_1_2_A; TIGR03228
1400867004883	Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469
1400867004884	[2Fe-2S] cluster binding site [ion binding]; other site
1400867004885	C-terminal catalytic domain of the oxygenase alpha subunit of Pseudomonas resinovorans strain CA10 anthranilate 1,2-dioxygenase and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_AntDO-like; cd08879
1400867004886	putative alpha subunit interface [polypeptide binding]; other site
1400867004887	putative active site [active]
1400867004888	putative substrate binding site [chemical binding]; other site
1400867004889	Fe binding site [ion binding]; other site
1400867004890	Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667
1400867004891	inter-subunit interface; other site
1400867004892	anthranilate dioxygenase reductase; Provisional; Region: antC; PRK11872
1400867004893	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
1400867004894	catalytic loop [active]
1400867004895	iron binding site [ion binding]; other site
1400867004896	Benzoate dioxygenase reductase (BenDO) FAD/NAD binding domain. Oxygenases oxidize hydrocarbons using dioxygen as the oxidant. As a Class I bacterial dioxygenases, benzoate dioxygenase like proteins combine an [2Fe-2S] cluster containing N-terminal...; Region: BenDO_FAD_NAD; cd06209
1400867004897	FAD binding pocket [chemical binding]; other site
1400867004898	FAD binding motif [chemical binding]; other site
1400867004899	phosphate binding motif [ion binding]; other site
1400867004900	beta-alpha-beta structure motif; other site
1400867004901	NAD binding pocket [chemical binding]; other site
1400867004902	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1400867004903	Helix-turn-helix domain; Region: HTH_18; pfam12833
1400867004904	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1400867004905	Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; cl01768
1400867004906	Flavin reductase like domain; Region: Flavin_Reduct; smart00903
1400867004907	short chain dehydrogenase; Provisional; Region: PRK08265
1400867004908	classical (c) SDRs; Region: SDR_c; cd05233
1400867004909	NAD(P) binding site [chemical binding]; other site
1400867004910	active site
1400867004911	Dienelactone hydrolase family; Region: DLH; pfam01738
1400867004912	SnoaL-like domain; Region: SnoaL_2; pfam12680
1400867004913	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1400867004914	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1400867004915	Helix-turn-helix domain; Region: HTH_18; pfam12833
1400867004916	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1400867004917	3-hydroxybutyrate dehydrogenase; Provisional; Region: PRK12429
1400867004918	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1400867004919	NAD(P) binding site [chemical binding]; other site
1400867004920	active site
1400867004921	H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610
1400867004922	fructuronate transporter; Provisional; Region: PRK10034; cl15264
1400867004923	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1400867004924	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1400867004925	DoxX; Region: DoxX; pfam07681
1400867004926	Protein of unknown function (DUF3298); Region: DUF3298; pfam11738
1400867004927	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1400867004928	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1400867004929	TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440
1400867004930	putative dimerization interface [polypeptide binding]; other site
1400867004931	Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788
1400867004932	3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428
1400867004933	Short chain fatty acids transporter [Lipid metabolism]; Region: AtoE; COG2031
1400867004934	acetyl-CoA acetyltransferase; Provisional; Region: PRK06954
1400867004935	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
1400867004936	dimer interface [polypeptide binding]; other site
1400867004937	active site
1400867004938	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1400867004939	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1400867004940	The C-terminal substrate binding domain of LysR-type transcriptional regulators that are involved in the catabolism of dinitrotoluene, naphthalene and gamma-hexachlorohexane; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_NahR_LinR_like; cd08459
1400867004941	substrate binding pocket [chemical binding]; other site
1400867004942	dimerization interface [polypeptide binding]; other site
1400867004943	cell density-dependent motility repressor; Provisional; Region: PRK10082
1400867004944	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1400867004945	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
1400867004946	dimerization interface [polypeptide binding]; other site
1400867004947	aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273
1400867004948	Aspartase; Region: Aspartase; cd01357
1400867004949	active sites [active]
1400867004950	tetramer interface [polypeptide binding]; other site
1400867004951	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
1400867004952	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
1400867004953	N-terminal plug; other site
1400867004954	ligand-binding site [chemical binding]; other site
1400867004955	alpha-ketoglutarate transporter; Provisional; Region: PRK10406
1400867004956	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1400867004957	putative substrate translocation pore; other site
1400867004958	Protein of unknown function (DUF971); Region: DUF971; pfam06155
1400867004959	HEAT repeats; Region: HEAT_2; pfam13646
1400867004960	HEAT repeats; Region: HEAT_2; pfam13646
1400867004961	HEAT repeats; Region: HEAT_2; pfam13646
1400867004962	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
1400867004963	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
1400867004964	Walker A/P-loop; other site
1400867004965	ATP binding site [chemical binding]; other site
1400867004966	Q-loop/lid; other site
1400867004967	ABC transporter signature motif; other site
1400867004968	Walker B; other site
1400867004969	D-loop; other site
1400867004970	H-loop/switch region; other site
1400867004971	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
1400867004972	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1400867004973	dimer interface [polypeptide binding]; other site
1400867004974	conserved gate region; other site
1400867004975	putative PBP binding loops; other site
1400867004976	ABC-ATPase subunit interface; other site
1400867004977	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432
1400867004978	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
1400867004979	substrate binding pocket [chemical binding]; other site
1400867004980	membrane-bound complex binding site; other site
1400867004981	Ferredoxin [Energy production and conversion]; Region: COG1146
1400867004982	putative oxidoreductase; Provisional; Region: PRK08275
1400867004983	L-aspartate oxidase; Provisional; Region: PRK06175
1400867004984	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
1400867004985	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
1400867004986	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1400867004987	DNA-binding site [nucleotide binding]; DNA binding site
1400867004988	UTRA domain; Region: UTRA; pfam07702
1400867004989	Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059
1400867004990	chromate transporter, chromate ion transporter (CHR) family; Region: 2A51; TIGR00937
1400867004991	Chromate transporter; Region: Chromate_transp; pfam02417
1400867004992	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
1400867004993	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
1400867004994	Predicted transcriptional regulators [Transcription]; Region: COG1733
1400867004995	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
1400867004996	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1400867004997	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1400867004998	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1400867004999	EamA-like transporter family; Region: EamA; pfam00892
1400867005000	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
1400867005001	EamA-like transporter family; Region: EamA; pfam00892
1400867005002	Homoserine dehydrogenase [Amino acid transport and metabolism]; Region: ThrA; COG0460
1400867005003	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
1400867005004	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
1400867005005	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
1400867005006	Putative phosphatase (DUF442); Region: DUF442; cl17385
1400867005007	Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446
1400867005008	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
1400867005009	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1400867005010	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
1400867005011	Walker A motif; other site
1400867005012	ATP binding site [chemical binding]; other site
1400867005013	Walker B motif; other site
1400867005014	arginine finger; other site
1400867005015	Bestrophin, RFP-TM, chloride channel; Region: Bestrophin; pfam01062
1400867005016	(2R,3R)-2,3-butanediol dehydrogenase; Region: butanediol_DH_like; cd08233
1400867005017	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
1400867005018	putative NAD(P) binding site [chemical binding]; other site
1400867005019	catalytic Zn binding site [ion binding]; other site
1400867005020	meso-2,3-butanediol dehydrogenase-like, classical (c) SDRs; Region: meso-BDH-like_SDR_c; cd05366
1400867005021	acetoin reductases; Region: 23BDH; TIGR02415
1400867005022	NAD binding site [chemical binding]; other site
1400867005023	homotetramer interface [polypeptide binding]; other site
1400867005024	homodimer interface [polypeptide binding]; other site
1400867005025	active site
1400867005026	substrate binding site [chemical binding]; other site
1400867005027	dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416
1400867005028	putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834
1400867005029	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1400867005030	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
1400867005031	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
1400867005032	E3 interaction surface; other site
1400867005033	lipoyl attachment site [posttranslational modification]; other site
1400867005034	dihydrolipoamide acetyltransferase; Provisional; Region: PRK14843
1400867005035	e3 binding domain; Region: E3_binding; pfam02817
1400867005036	e3 binding domain; Region: E3_binding; pfam02817
1400867005037	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
1400867005038	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022
1400867005039	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
1400867005040	alpha subunit interface [polypeptide binding]; other site
1400867005041	TPP binding site [chemical binding]; other site
1400867005042	heterodimer interface [polypeptide binding]; other site
1400867005043	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
1400867005044	pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182
1400867005045	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
1400867005046	tetramer interface [polypeptide binding]; other site
1400867005047	TPP-binding site [chemical binding]; other site
1400867005048	heterodimer interface [polypeptide binding]; other site
1400867005049	phosphorylation loop region [posttranslational modification]
1400867005050	lipoyl synthase; Provisional; Region: PRK12928
1400867005051	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1400867005052	FeS/SAM binding site; other site
1400867005053	Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862
1400867005054	TENA/THI-4/PQQC family; Region: TENA_THI-4; cl15243
1400867005055	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1400867005056	metal binding site [ion binding]; metal-binding site
1400867005057	active site
1400867005058	I-site; other site
1400867005059	Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082
1400867005060	Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304
1400867005061	Tetramer interface [polypeptide binding]; other site
1400867005062	active site
1400867005063	FMN-binding site [chemical binding]; other site
1400867005064	HemK family putative methylases; Region: hemK_fam; TIGR00536
1400867005065	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1400867005066	S-adenosylmethionine binding site [chemical binding]; other site
1400867005067	tryptophan synthase, beta subunit; Region: trpB; TIGR00263
1400867005068	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
1400867005069	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1400867005070	catalytic residue [active]
1400867005071	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3825
1400867005072	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1400867005073	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
1400867005074	Walker A motif; other site
1400867005075	ATP binding site [chemical binding]; other site
1400867005076	Walker B motif; other site
1400867005077	arginine finger; other site
1400867005078	YcgL domain; Region: YcgL; pfam05166
1400867005079	Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349
1400867005080	DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142
1400867005081	catalytic site [active]
1400867005082	putative active site [active]
1400867005083	putative substrate binding site [chemical binding]; other site
1400867005084	HRDC domain; Region: HRDC; pfam00570
1400867005085	recombination protein RecR; Reviewed; Region: recR; PRK00076
1400867005086	RecR protein; Region: RecR; pfam02132
1400867005087	TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR.  RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025
1400867005088	putative active site [active]
1400867005089	putative metal-binding site [ion binding]; other site
1400867005090	tetramer interface [polypeptide binding]; other site
1400867005091	hypothetical protein; Validated; Region: PRK00153
1400867005092	O-succinylhomoserine sulfhydrylase; Validated; Region: PRK08133
1400867005093	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
1400867005094	homodimer interface [polypeptide binding]; other site
1400867005095	substrate-cofactor binding pocket; other site
1400867005096	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1400867005097	catalytic residue [active]
1400867005098	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
1400867005099	Methyltransferase domain; Region: Methyltransf_23; pfam13489
1400867005100	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1400867005101	S-adenosylmethionine binding site [chemical binding]; other site
1400867005102	TonB C terminal; Region: TonB_2; pfam13103
1400867005103	TolA protein; Region: tolA_full; TIGR02794
1400867005104	Uncharacterized conserved protein [Function unknown]; Region: COG3791
1400867005105	HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277
1400867005106	HIT family signature motif; other site
1400867005107	catalytic residue [active]
1400867005108	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
1400867005109	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
1400867005110	eyelet of channel; other site
1400867005111	trimer interface [polypeptide binding]; other site
1400867005112	Bacterial protein of unknown function (DUF937); Region: DUF937; cl01528
1400867005113	Protein of unknown function (DUF2797); Region: DUF2797; pfam10977
1400867005114	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
1400867005115	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
1400867005116	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
1400867005117	ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679
1400867005118	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
1400867005119	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1400867005120	Walker A/P-loop; other site
1400867005121	ATP binding site [chemical binding]; other site
1400867005122	Q-loop/lid; other site
1400867005123	ABC transporter signature motif; other site
1400867005124	Walker B; other site
1400867005125	D-loop; other site
1400867005126	H-loop/switch region; other site
1400867005127	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
1400867005128	ATP-binding cassette domain of the lipid transporters, subfamily A; Region: ABC_subfamily_A; cd03263
1400867005129	Walker A/P-loop; other site
1400867005130	ATP binding site [chemical binding]; other site
1400867005131	Q-loop/lid; other site
1400867005132	ABC transporter signature motif; other site
1400867005133	Walker B; other site
1400867005134	D-loop; other site
1400867005135	H-loop/switch region; other site
1400867005136	putative efflux pump membrane fusion protein; Provisional; Region: PRK03598
1400867005137	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
1400867005138	HlyD family secretion protein; Region: HlyD_3; pfam13437
1400867005139	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1400867005140	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1400867005141	Domain of unknown function (DUF1956); Region: DUF1956; pfam09209
1400867005142	lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025
1400867005143	ipid-A-disaccharide synthase; Provisional; Region: PRK14089
1400867005144	Outer membrane receptor for ferric coprogen and ferric-rhodotorulic acid [Inorganic ion transport and metabolism]; Region: FhuE; COG4773
1400867005145	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
1400867005146	N-terminal plug; other site
1400867005147	ligand-binding site [chemical binding]; other site
1400867005148	Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182
1400867005149	PepSY-associated TM helix; Region: PepSY_TM_3; pfam13706
1400867005150	PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703
1400867005151	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
1400867005152	phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261
1400867005153	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
1400867005154	cobalamin synthase; Reviewed; Region: cobS; PRK00235
1400867005155	Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cl11399
1400867005156	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
1400867005157	catalytic core [active]
1400867005158	Phosphoribosyltransferase; Region: DBI_PRT; pfam02277
1400867005159	Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439
1400867005160	putative dimer interface [polypeptide binding]; other site
1400867005161	active site pocket [active]
1400867005162	putative cataytic base [active]
1400867005163	Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544
1400867005164	homotrimer interface [polypeptide binding]; other site
1400867005165	Walker A motif; other site
1400867005166	GTP binding site [chemical binding]; other site
1400867005167	Walker B motif; other site
1400867005168	2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563
1400867005169	Cellular and retroviral pepsin-like aspartate proteases; Region: pepsin_retropepsin_like; cl11403
1400867005170	beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009
1400867005171	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1400867005172	motif II; other site
1400867005173	Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125
1400867005174	Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523
1400867005175	Siderophore biosynthesis protein domain; Region: AlcB; smart01006
1400867005176	PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703
1400867005177	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
1400867005178	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
1400867005179	N-terminal plug; other site
1400867005180	ligand-binding site [chemical binding]; other site
1400867005181	Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480
1400867005182	FhuF 2Fe-2S C-terminal domain; Region: FhuF_C; pfam11575
1400867005183	IucA / IucC family; Region: IucA_IucC; pfam04183
1400867005184	Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276
1400867005185	Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264
1400867005186	IucA / IucC family; Region: IucA_IucC; pfam04183
1400867005187	Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276
1400867005188	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1400867005189	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1400867005190	putative substrate translocation pore; other site
1400867005191	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1400867005192	Lysine/ornithine N-monooxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: IucD; COG3486
1400867005193	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1400867005194	Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264
1400867005195	IucA / IucC family; Region: IucA_IucC; pfam04183
1400867005196	Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276
1400867005197	This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002
1400867005198	putative deacylase active site [active]
1400867005199	Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661
1400867005200	ABC1 family; Region: ABC1; cl17513
1400867005201	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
1400867005202	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
1400867005203	active site
1400867005204	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
1400867005205	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
1400867005206	active site
1400867005207	Alkane hydroxylase is a bacterial, integral-membrane di-iron enzyme that shares a requirement for iron and oxygen for activity similar to that of the non-heme integral-membrane acyl coenzyme A (CoA) desaturases and acyl lipid desaturases. The alk genes...; Region: Alkane-hydroxylase; cd03512
1400867005208	Fatty acid desaturase; Region: FA_desaturase; pfam00487
1400867005209	Di-iron ligands [ion binding]; other site
1400867005210	Cupin; Region: Cupin_6; pfam12852
1400867005211	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1400867005212	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1400867005213	periplasmic folding chaperone; Provisional; Region: PRK10788
1400867005214	SurA N-terminal domain; Region: SurA_N_3; cl07813
1400867005215	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
1400867005216	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
1400867005217	IHF dimer interface [polypeptide binding]; other site
1400867005218	IHF - DNA interface [nucleotide binding]; other site
1400867005219	Poly(hydroxyalcanoate) granule associated protein (phasin); Region: Phasin; pfam05597
1400867005220	Transcriptional regulator; Region: Rrf2; cl17282
1400867005221	Rrf2 family protein; Region: rrf2_super; TIGR00738
1400867005222	cysteine desulfurase; Provisional; Region: PRK14012
1400867005223	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
1400867005224	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1400867005225	catalytic residue [active]
1400867005226	NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822
1400867005227	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664
1400867005228	trimerization site [polypeptide binding]; other site
1400867005229	active site
1400867005230	Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400
1400867005231	co-chaperone HscB; Provisional; Region: hscB; PRK05014
1400867005232	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
1400867005233	HSP70 interaction site [polypeptide binding]; other site
1400867005234	HSCB C-terminal oligomerisation domain; Region: HSCB_C; pfam07743
1400867005235	chaperone protein HscA; Provisional; Region: hscA; PRK05183
1400867005236	Nucleotide-binding domain of HscA and similar proteins; Region: HscA_like_NBD; cd10236
1400867005237	nucleotide binding site [chemical binding]; other site
1400867005238	putative NEF/HSP70 interaction site [polypeptide binding]; other site
1400867005239	SBD interface [polypeptide binding]; other site
1400867005240	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
1400867005241	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
1400867005242	catalytic loop [active]
1400867005243	iron binding site [ion binding]; other site
1400867005244	MerC mercury resistance protein; Region: MerC; cl03934
1400867005245	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
1400867005246	cyclase homology domain; Region: CHD; cd07302
1400867005247	nucleotidyl binding site; other site
1400867005248	metal binding site [ion binding]; metal-binding site
1400867005249	dimer interface [polypeptide binding]; other site
1400867005250	HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228
1400867005251	Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197
1400867005252	CarD-like/TRCF domain; Region: CarD_TRCF; smart01058
1400867005253	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1400867005254	ATP binding site [chemical binding]; other site
1400867005255	putative Mg++ binding site [ion binding]; other site
1400867005256	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1400867005257	nucleotide binding region [chemical binding]; other site
1400867005258	ATP-binding site [chemical binding]; other site
1400867005259	This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982
1400867005260	Dyp-type peroxidase family; Region: Dyp_perox; cl01067
1400867005261	GST_N family, 2 repeats of the N-terminal domain of soluble GSTs (2 GST_N) subfamily; composed of uncharacterized proteins. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a...; Region: GST_N_2GST_N; cd03041
1400867005262	putative C-terminal domain interface [polypeptide binding]; other site
1400867005263	putative GSH binding site (G-site) [chemical binding]; other site
1400867005264	putative dimer interface [polypeptide binding]; other site
1400867005265	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
1400867005266	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
1400867005267	ribonuclease activity regulator protein RraA; Provisional; Region: PRK09372
1400867005268	CC3(TIP30)-like, atypical (a) SDRs; Region: CC3_like_SDR_a; cd05250
1400867005269	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
1400867005270	NAD binding site [chemical binding]; other site
1400867005271	active site
1400867005272	30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239
1400867005273	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
1400867005274	catalytic core [active]
1400867005275	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
1400867005276	CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638
1400867005277	active site
1400867005278	Uncharacterized ACR, COG2135; Region: DUF159; pfam02586
1400867005279	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
1400867005280	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1400867005281	Walker A/P-loop; other site
1400867005282	ATP binding site [chemical binding]; other site
1400867005283	Q-loop/lid; other site
1400867005284	ABC transporter signature motif; other site
1400867005285	Walker B; other site
1400867005286	D-loop; other site
1400867005287	H-loop/switch region; other site
1400867005288	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1400867005289	Walker A/P-loop; other site
1400867005290	ATP binding site [chemical binding]; other site
1400867005291	Q-loop/lid; other site
1400867005292	ABC transporter signature motif; other site
1400867005293	Walker B; other site
1400867005294	D-loop; other site
1400867005295	H-loop/switch region; other site
1400867005296	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
1400867005297	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
1400867005298	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1400867005299	dimer interface [polypeptide binding]; other site
1400867005300	conserved gate region; other site
1400867005301	putative PBP binding loops; other site
1400867005302	ABC-ATPase subunit interface; other site
1400867005303	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
1400867005304	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1400867005305	dimer interface [polypeptide binding]; other site
1400867005306	conserved gate region; other site
1400867005307	putative PBP binding loops; other site
1400867005308	ABC-ATPase subunit interface; other site
1400867005309	Peptidase M3 Thimet oligopeptidase (TOP) also includes neurolysin; Region: M3A_TOP; cd06455
1400867005310	Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339
1400867005311	active site
1400867005312	Zn binding site [ion binding]; other site
1400867005313	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_18; cd08505
1400867005314	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
1400867005315	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_18; cd08505
1400867005316	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
1400867005317	TonB-dependent receptor; Region: TonB-Xanth-Caul; TIGR01782
1400867005318	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
1400867005319	N-terminal plug; other site
1400867005320	ligand-binding site [chemical binding]; other site
1400867005321	Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810
1400867005322	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
1400867005323	Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811
1400867005324	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
1400867005325	Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472
1400867005326	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
1400867005327	Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472
1400867005328	malate synthase G; Provisional; Region: PRK02999
1400867005329	active site
1400867005330	Predicted ATPase [General function prediction only]; Region: COG1485
1400867005331	Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625
1400867005332	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1400867005333	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1400867005334	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
1400867005335	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
1400867005336	Membrane protein of unknown function (DUF340); Region: DUF340; cl01028
1400867005337	Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725
1400867005338	active site
1400867005339	dimer interface [polypeptide binding]; other site
1400867005340	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
1400867005341	IHF dimer interface [polypeptide binding]; other site
1400867005342	IHF - DNA interface [nucleotide binding]; other site
1400867005343	30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299
1400867005344	S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687
1400867005345	RNA binding site [nucleotide binding]; other site
1400867005346	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
1400867005347	RNA binding site [nucleotide binding]; other site
1400867005348	S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688
1400867005349	RNA binding site [nucleotide binding]; other site
1400867005350	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
1400867005351	RNA binding site [nucleotide binding]; other site
1400867005352	S1_RPS1_repeat_ec5: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec5; cd05690
1400867005353	RNA binding site [nucleotide binding]; other site
1400867005354	S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec6; cd05691
1400867005355	RNA binding site [nucleotide binding]; other site
1400867005356	cytidylate kinase; Provisional; Region: cmk; PRK00023
1400867005357	Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020
1400867005358	CMP-binding site; other site
1400867005359	The sites determining sugar specificity; other site
1400867005360	Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821
1400867005361	putative hydrophobic ligand binding site [chemical binding]; other site
1400867005362	protein interface [polypeptide binding]; other site
1400867005363	gate; other site
1400867005364	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
1400867005365	nucleoside/Zn binding site; other site
1400867005366	dimer interface [polypeptide binding]; other site
1400867005367	catalytic motif [active]
1400867005368	3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617
1400867005369	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
1400867005370	substrate binding site [chemical binding]; other site
1400867005371	oxyanion hole (OAH) forming residues; other site
1400867005372	trimer interface [polypeptide binding]; other site
1400867005373	2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766
1400867005374	Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027
1400867005375	ligand binding site [chemical binding]; other site
1400867005376	active site
1400867005377	UGI interface [polypeptide binding]; other site
1400867005378	catalytic site [active]
1400867005379	6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242
1400867005380	Type II secretion system (T2SS), protein K; Region: T2SK; pfam03934
1400867005381	Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544
1400867005382	type II secretion system protein J; Region: gspJ; TIGR01711
1400867005383	Type II secretion system (T2SS), protein J; Region: T2SJ; pfam11612
1400867005384	Type II secretion system (T2SS), protein I; Region: T2SI; pfam02501
1400867005385	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1400867005386	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1400867005387	Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099
1400867005388	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
1400867005389	active site
1400867005390	PilZ domain; Region: PilZ; cl01260
1400867005391	DNA polymerase III, delta' subunit; Region: holB; TIGR00678
1400867005392	ATPase involved in DNA replication [DNA replication, recombination, and repair]; Region: HolB; COG0470
1400867005393	3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450
1400867005394	CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517
1400867005395	Ligand binding site; other site
1400867005396	oligomer interface; other site
1400867005397	Tetraacyldisaccharide-1-P 4'-kinase [Cell envelope biogenesis, outer membrane]; Region: LpxK; COG1663
1400867005398	Tetraacyldisaccharide-1-P 4'-kinase; Region: LpxK; pfam02606
1400867005399	lipid A export permease/ATP-binding protein MsbA; Region: MsbA_lipidA; TIGR02203
1400867005400	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1400867005401	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
1400867005402	Walker A/P-loop; other site
1400867005403	ATP binding site [chemical binding]; other site
1400867005404	Q-loop/lid; other site
1400867005405	ABC transporter signature motif; other site
1400867005406	Walker B; other site
1400867005407	D-loop; other site
1400867005408	H-loop/switch region; other site
1400867005409	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
1400867005410	Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472
1400867005411	Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811
1400867005412	ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180
1400867005413	ParB-like nuclease domain; Region: ParB; smart00470
1400867005414	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
1400867005415	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
1400867005416	P-loop; other site
1400867005417	Magnesium ion binding site [ion binding]; other site
1400867005418	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
1400867005419	Magnesium ion binding site [ion binding]; other site
1400867005420	16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107
1400867005421	rRNA small subunit methyltransferase G; Region: GidB; pfam02527
1400867005422	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
1400867005423	NTP_transferase_like_1 is a member of the nucleotidyl transferase family; Region: NTP_transferase_like_1; cd06422
1400867005424	Substrate binding site; other site
1400867005425	metal-binding site
1400867005426	Predicted phosphotransferase related to Ser/Thr protein kinases [General function prediction only]; Region: COG3178
1400867005427	Phosphotransferase enzyme family; Region: APH; pfam01636
1400867005428	Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452
1400867005429	OstA-like protein; Region: OstA; cl00844
1400867005430	Organic solvent tolerance protein; Region: OstA_C; pfam04453
1400867005431	peptidyl-prolyl cis-trans isomerase SurA; Provisional; Region: PRK10770
1400867005432	SurA N-terminal domain; Region: SurA_N; pfam09312
1400867005433	PPIC-type PPIASE domain; Region: Rotamase_2; cl08278
1400867005434	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
1400867005435	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947
1400867005436	fructose-bisphosphate aldolase; Provisional; Region: PRK09197
1400867005437	intersubunit interface [polypeptide binding]; other site
1400867005438	active site
1400867005439	zinc binding site [ion binding]; other site
1400867005440	Na+ binding site [ion binding]; other site
1400867005441	phosphoglycerate kinase; Provisional; Region: pgk; PRK00073
1400867005442	Phosphoglycerate kinase; Region: PGK; pfam00162
1400867005443	substrate binding site [chemical binding]; other site
1400867005444	hinge regions; other site
1400867005445	ADP binding site [chemical binding]; other site
1400867005446	catalytic site [active]
1400867005447	Uncharacterized protein conserved in bacteria (DUF2237); Region: DUF2237; pfam09996
1400867005448	Maf-like protein; Region: Maf; pfam02545
1400867005449	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
1400867005450	active site
1400867005451	dimer interface [polypeptide binding]; other site
1400867005452	Cupin superfamily protein; Region: Cupin_4; pfam08007
1400867005453	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1400867005454	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1400867005455	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1400867005456	dimerization interface [polypeptide binding]; other site
1400867005457	putative DNA binding site [nucleotide binding]; other site
1400867005458	putative Zn2+ binding site [ion binding]; other site
1400867005459	serine/threonine transporter SstT; Provisional; Region: PRK13628
1400867005460	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
1400867005461	Protein of unknown function (DUF1275); Region: DUF1275; pfam06912
1400867005462	Uncharacterized protein conserved in bacteria (DUF2058); Region: DUF2058; pfam09831
1400867005463	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
1400867005464	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1400867005465	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
1400867005466	Walker A/P-loop; other site
1400867005467	ATP binding site [chemical binding]; other site
1400867005468	Q-loop/lid; other site
1400867005469	ABC transporter signature motif; other site
1400867005470	Walker B; other site
1400867005471	D-loop; other site
1400867005472	H-loop/switch region; other site
1400867005473	YdeM is a Bacillus subtilis protein that belongs to a family of prokaryotic proteins of unkown function.  YdeM has sequence similarity to the hot-dog fold of (R)-specific enoyl-CoA hydratase.   Other enzymes with this fold include the peroxisomal...; Region: YdeM; cd03454
1400867005474	putative active site [active]
1400867005475	putative catalytic site [active]
1400867005476	Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625
1400867005477	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1400867005478	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1400867005479	Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848
1400867005480	lipoyl attachment site [posttranslational modification]; other site
1400867005481	NAD-dependent deacetylase; Provisional; Region: PRK00481
1400867005482	SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412
1400867005483	NAD+ binding site [chemical binding]; other site
1400867005484	substrate binding site [chemical binding]; other site
1400867005485	Zn binding site [ion binding]; other site
1400867005486	Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475
1400867005487	Na binding site [ion binding]; other site
1400867005488	leucine-responsive transcriptional regulator; Provisional; Region: PRK11169
1400867005489	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1400867005490	dimerization interface [polypeptide binding]; other site
1400867005491	putative DNA binding site [nucleotide binding]; other site
1400867005492	putative Zn2+ binding site [ion binding]; other site
1400867005493	AsnC family; Region: AsnC_trans_reg; pfam01037
1400867005494	bifunctional proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: PRK11905
1400867005495	Proline dehydrogenase [Amino acid transport and metabolism]; Region: PutA; COG0506
1400867005496	Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125
1400867005497	Glutamate binding site [chemical binding]; other site
1400867005498	NAD binding site [chemical binding]; other site
1400867005499	catalytic residues [active]
1400867005500	Uncharacterized protein family (UPF0157); Region: UPF0157; cl00987
1400867005501	tRNA (uracil-5-)-methyltransferase; Validated; Region: PRK05031
1400867005502	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1400867005503	S-adenosylmethionine binding site [chemical binding]; other site
1400867005504	Predicted periplasmic protein [Function unknown]; Region: COG3698
1400867005505	Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992
1400867005506	Lecithin retinol acyltransferase; Region: LRAT; pfam04970
1400867005507	Uncharacterized conserved protein [Function unknown]; Region: COG2353
1400867005508	OsmC-like protein; Region: OsmC; pfam02566
1400867005509	transketolase; Reviewed; Region: PRK12753
1400867005510	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
1400867005511	TPP-binding site [chemical binding]; other site
1400867005512	dimer interface [polypeptide binding]; other site
1400867005513	ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192
1400867005514	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
1400867005515	PYR/PP interface [polypeptide binding]; other site
1400867005516	dimer interface [polypeptide binding]; other site
1400867005517	TPP binding site [chemical binding]; other site
1400867005518	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
1400867005519	S-adenosylmethionine synthetase; Validated; Region: PRK05250
1400867005520	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
1400867005521	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
1400867005522	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
1400867005523	N2,N2-dimethylguanosine tRNA methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TRM1; COG1867
1400867005524	FxsA cytoplasmic membrane protein; Region: FxsA; pfam04186
1400867005525	Beta-lactamase class D [Defense mechanisms]; Region: COG2602
1400867005526	Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247
1400867005527	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
1400867005528	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1400867005529	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1400867005530	non-specific DNA binding site [nucleotide binding]; other site
1400867005531	salt bridge; other site
1400867005532	sequence-specific DNA binding site [nucleotide binding]; other site
1400867005533	Cupin domain; Region: Cupin_2; cl17218
1400867005534	Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529
1400867005535	active site
1400867005536	putative DNA-binding cleft [nucleotide binding]; other site
1400867005537	dimer interface [polypeptide binding]; other site
1400867005538	putative carbohydrate kinase; Provisional; Region: PRK10565
1400867005539	YjeF-related protein N-terminus; Region: YjeF_N; pfam03853
1400867005540	B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171
1400867005541	putative substrate binding site [chemical binding]; other site
1400867005542	putative ATP binding site [chemical binding]; other site
1400867005543	epoxyqueuosine reductase; Region: TIGR00276
1400867005544	Domain of unknown function (DUF1730); Region: DUF1730; pfam08331
1400867005545	biotin synthase; Provisional; Region: PRK15108
1400867005546	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1400867005547	FeS/SAM binding site; other site
1400867005548	Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876
1400867005549	P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539
1400867005550	P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121
1400867005551	Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345
1400867005552	Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753
1400867005553	P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188
1400867005554	PapC N-terminal domain; Region: PapC_N; pfam13954
1400867005555	Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577
1400867005556	PapC C-terminal domain; Region: PapC_C; pfam13953
1400867005557	putative major fimbrial protein SthE; Provisional; Region: PRK15292
1400867005558	P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539
1400867005559	Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625
1400867005560	Helix-turn-helix domain; Region: HTH_18; pfam12833
1400867005561	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1400867005562	Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000
1400867005563	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1400867005564	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1400867005565	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1400867005566	dimerization interface [polypeptide binding]; other site
1400867005567	EamA-like transporter family; Region: EamA; pfam00892
1400867005568	Purine-cytosine permease and related proteins [Nucleotide transport and metabolism]; Region: CodB; COG1457
1400867005569	Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133
1400867005570	Na binding site [ion binding]; other site
1400867005571	Predicted membrane protein [Function unknown]; Region: COG4125
1400867005572	Bacterial Transmembrane Pair family; Region: BTP; pfam05232
1400867005573	Bacterial Transmembrane Pair family; Region: BTP; pfam05232
1400867005574	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1400867005575	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1400867005576	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
1400867005577	dimerization interface [polypeptide binding]; other site
1400867005578	Domain of unknown function (DUF4102); Region: DUF4102; pfam13356
1400867005579	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
1400867005580	active site
1400867005581	Int/Topo IB signature motif; other site
1400867005582	DNA binding site [nucleotide binding]
1400867005583	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1400867005584	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1400867005585	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown ABO13168; Region: LPLAT_ABO13168-like; cd07988
1400867005586	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
1400867005587	putative acyl-acceptor binding pocket; other site
1400867005588	hypothetical protein; Validated; Region: PRK00110
1400867005589	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
1400867005590	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1400867005591	putative DNA binding site [nucleotide binding]; other site
1400867005592	putative Zn2+ binding site [ion binding]; other site
1400867005593	AsnC family; Region: AsnC_trans_reg; pfam01037
1400867005594	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
1400867005595	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
1400867005596	Walker A/P-loop; other site
1400867005597	ATP binding site [chemical binding]; other site
1400867005598	Q-loop/lid; other site
1400867005599	ABC transporter signature motif; other site
1400867005600	Walker B; other site
1400867005601	D-loop; other site
1400867005602	H-loop/switch region; other site
1400867005603	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
1400867005604	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1400867005605	dimer interface [polypeptide binding]; other site
1400867005606	conserved gate region; other site
1400867005607	putative PBP binding loops; other site
1400867005608	ABC-ATPase subunit interface; other site
1400867005609	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
1400867005610	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1400867005611	dimer interface [polypeptide binding]; other site
1400867005612	conserved gate region; other site
1400867005613	putative PBP binding loops; other site
1400867005614	ABC-ATPase subunit interface; other site
1400867005615	glutamate and aspartate transporter subunit; Provisional; Region: PRK10797
1400867005616	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1400867005617	substrate binding pocket [chemical binding]; other site
1400867005618	membrane-bound complex binding site; other site
1400867005619	hinge residues; other site
1400867005620	Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of  glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570
1400867005621	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
1400867005622	C-terminal domain interface [polypeptide binding]; other site
1400867005623	GSH binding site (G-site) [chemical binding]; other site
1400867005624	dimer interface [polypeptide binding]; other site
1400867005625	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776
1400867005626	N-terminal domain interface [polypeptide binding]; other site
1400867005627	sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022
1400867005628	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
1400867005629	active site
1400867005630	sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022
1400867005631	Dibenzothiophene (DBT) desulfurization enzyme C; Region: DszC; cd01163
1400867005632	Flavin binding site [chemical binding]; other site
1400867005633	FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860
1400867005634	nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095
1400867005635	active site
1400867005636	non-prolyl cis peptide bond; other site
1400867005637	NLPA lipoprotein; Region: Lipoprotein_9; pfam03180
1400867005638	NLPA lipoprotein; Region: Lipoprotein_9; pfam03180
1400867005639	DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153
1400867005640	ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258
1400867005641	Walker A/P-loop; other site
1400867005642	ATP binding site [chemical binding]; other site
1400867005643	Q-loop/lid; other site
1400867005644	ABC transporter signature motif; other site
1400867005645	Walker B; other site
1400867005646	D-loop; other site
1400867005647	H-loop/switch region; other site
1400867005648	This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930
1400867005649	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1400867005650	dimer interface [polypeptide binding]; other site
1400867005651	conserved gate region; other site
1400867005652	ABC-ATPase subunit interface; other site
1400867005653	GTP-binding protein YchF; Reviewed; Region: PRK09601
1400867005654	YchF GTPase; Region: YchF; cd01900
1400867005655	G1 box; other site
1400867005656	GTP/Mg2+ binding site [chemical binding]; other site
1400867005657	Switch I region; other site
1400867005658	G2 box; other site
1400867005659	Switch II region; other site
1400867005660	G3 box; other site
1400867005661	G4 box; other site
1400867005662	G5 box; other site
1400867005663	TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867
1400867005664	Predicted membrane protein [Function unknown]; Region: COG4539
1400867005665	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
1400867005666	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
1400867005667	ligand binding site [chemical binding]; other site
1400867005668	flexible hinge region; other site
1400867005669	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
1400867005670	putative switch regulator; other site
1400867005671	non-specific DNA interactions [nucleotide binding]; other site
1400867005672	DNA binding site [nucleotide binding]
1400867005673	sequence specific DNA binding site [nucleotide binding]; other site
1400867005674	putative cAMP binding site [chemical binding]; other site
1400867005675	AzlC protein; Region: AzlC; cl00570
1400867005676	putative L-valine exporter; Provisional; Region: PRK10408
1400867005677	4-Oxalocrotonate Tautomerase:  Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235
1400867005678	active site 1 [active]
1400867005679	dimer interface [polypeptide binding]; other site
1400867005680	hexamer interface [polypeptide binding]; other site
1400867005681	active site 2 [active]
1400867005682	phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288
1400867005683	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1400867005684	ATP-grasp domain; Region: ATP-grasp; pfam02222
1400867005685	PII uridylyl-transferase; Provisional; Region: glnD; PRK00275
1400867005686	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
1400867005687	metal binding triad; other site
1400867005688	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
1400867005689	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
1400867005690	Zn2+ binding site [ion binding]; other site
1400867005691	Mg2+ binding site [ion binding]; other site
1400867005692	ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900
1400867005693	C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899
1400867005694	succinyldiaminopimelate transaminase; Provisional; Region: PRK09147
1400867005695	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1400867005696	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1400867005697	homodimer interface [polypeptide binding]; other site
1400867005698	catalytic residue [active]
1400867005699	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
1400867005700	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
1400867005701	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1400867005702	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1400867005703	Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340
1400867005704	catalytic residues [active]
1400867005705	dimer interface [polypeptide binding]; other site
1400867005706	methionine sulfoxide reductase B; Provisional; Region: PRK00222
1400867005707	SelR domain; Region: SelR; pfam01641
1400867005708	aminotransferase AlaT; Validated; Region: PRK09265
1400867005709	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1400867005710	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1400867005711	homodimer interface [polypeptide binding]; other site
1400867005712	catalytic residue [active]
1400867005713	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
1400867005714	Sodium:dicarboxylate symporter family; Region: SDF; cl00573
1400867005715	Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964
1400867005716	active site
1400867005717	homodimer interface [polypeptide binding]; other site
1400867005718	homotetramer interface [polypeptide binding]; other site
1400867005719	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433
1400867005720	DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673
1400867005721	putative active site [active]
1400867005722	putative PHP Thumb interface [polypeptide binding]; other site
1400867005723	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
1400867005724	generic binding surface I; other site
1400867005725	generic binding surface II; other site
1400867005726	rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565
1400867005727	SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307
1400867005728	serine O-acetyltransferase; Region: cysE; TIGR01172
1400867005729	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
1400867005730	trimer interface [polypeptide binding]; other site
1400867005731	active site
1400867005732	substrate binding site [chemical binding]; other site
1400867005733	CoA binding site [chemical binding]; other site
1400867005734	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
1400867005735	TPR motif; other site
1400867005736	binding surface
1400867005737	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
1400867005738	Chromate transporter; Region: Chromate_transp; pfam02417
1400867005739	Chromate transporter; Region: Chromate_transp; pfam02417
1400867005740	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1400867005741	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1400867005742	The C-terminal substrate binding domain of LysR-type transcrptional regulator BudR, which is responsible for activation of the expression of the butanediol operon genes; contains the type 2 periplasmic binding fold; Region: PBP2_BudR; cd08451
1400867005743	putative dimerization interface [polypeptide binding]; other site
1400867005744	putative substrate binding pocket [chemical binding]; other site
1400867005745	Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798
1400867005746	arsenical-resistance protein; Region: acr3; TIGR00832
1400867005747	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1400867005748	dimerization interface [polypeptide binding]; other site
1400867005749	putative DNA binding site [nucleotide binding]; other site
1400867005750	putative Zn2+ binding site [ion binding]; other site
1400867005751	Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034
1400867005752	ArsC family; Region: ArsC; pfam03960
1400867005753	catalytic residues [active]
1400867005754	Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574
1400867005755	YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300
1400867005756	active site
1400867005757	YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012
1400867005758	Isochorismatase family; Region: Isochorismatase; pfam00857
1400867005759	catalytic triad [active]
1400867005760	dimer interface [polypeptide binding]; other site
1400867005761	conserved cis-peptide bond; other site
1400867005762	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1400867005763	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
1400867005764	putative effector binding pocket; other site
1400867005765	dimerization interface [polypeptide binding]; other site
1400867005766	Transcriptional regulators [Transcription]; Region: GntR; COG1802
1400867005767	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1400867005768	DNA-binding site [nucleotide binding]; DNA binding site
1400867005769	FCD domain; Region: FCD; pfam07729
1400867005770	uncharacterized nucleobase-cation-symport-1 (NCS1) transporter subfamily; solute-binding domain; Region: SLC-NCS1sbd_u1; cd11555
1400867005771	Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133
1400867005772	Na binding site [ion binding]; other site
1400867005773	putative substrate binding site [chemical binding]; other site
1400867005774	Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518
1400867005775	taurine dioxygenase; Reviewed; Region: tauD; PRK09553
1400867005776	Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175
1400867005777	active site
1400867005778	iron coordination sites [ion binding]; other site
1400867005779	substrate binding pocket [chemical binding]; other site
1400867005780	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
1400867005781	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1400867005782	dimer interface [polypeptide binding]; other site
1400867005783	conserved gate region; other site
1400867005784	putative PBP binding loops; other site
1400867005785	ABC-ATPase subunit interface; other site
1400867005786	taurine transporter ATP-binding subunit; Provisional; Region: tauB; PRK11248
1400867005787	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
1400867005788	Walker A/P-loop; other site
1400867005789	ATP binding site [chemical binding]; other site
1400867005790	Q-loop/lid; other site
1400867005791	ABC transporter signature motif; other site
1400867005792	Walker B; other site
1400867005793	D-loop; other site
1400867005794	H-loop/switch region; other site
1400867005795	taurine ABC transporter, periplasmic binding protein; Region: taurine_ABC_bnd; TIGR01729
1400867005796	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1400867005797	substrate binding pocket [chemical binding]; other site
1400867005798	membrane-bound complex binding site; other site
1400867005799	hinge residues; other site
1400867005800	Sugar (and other) transporter; Region: Sugar_tr; pfam00083
1400867005801	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1400867005802	putative substrate translocation pore; other site
1400867005803	FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860
1400867005804	nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095
1400867005805	active site
1400867005806	non-prolyl cis peptide bond; other site
1400867005807	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
1400867005808	sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022
1400867005809	active site
1400867005810	Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654
1400867005811	Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322
1400867005812	cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219
1400867005813	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
1400867005814	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1400867005815	DNA-binding site [nucleotide binding]; DNA binding site
1400867005816	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1400867005817	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1400867005818	homodimer interface [polypeptide binding]; other site
1400867005819	catalytic residue [active]
1400867005820	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1400867005821	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1400867005822	The C-terminal substrate-binding domian of LysR-type transcriptional regulator MdcR, which involved in the malonate catabolism contains the type 2 periplasmic binding fold; Region: PBP2_MdcR; cd08416
1400867005823	putative dimerization interface [polypeptide binding]; other site
1400867005824	malonate transporter, MadM subunit; Region: malonate_madM; TIGR00808
1400867005825	malonate transporter, MadL subunit; Region: malonate_madL; TIGR00807
1400867005826	malonate decarboxylase, epsilon subunit; Region: malonate_mdcH; TIGR03131
1400867005827	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
1400867005828	phosphoribosyl-dephospho-CoA transferase; Provisional; Region: PRK01293
1400867005829	Phosphoribosyl-dephospho-CoA transferase MdcG; Region: MdcG; pfam10620
1400867005830	malonate decarboxylase, gamma subunit; Region: malonate_gamma; TIGR03134
1400867005831	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189
1400867005832	malonate decarboxylase subunit delta; Provisional; Region: PRK01220
1400867005833	triphosphoribosyl-dephospho-CoA synthase; Validated; Region: PRK01237
1400867005834	malonate decarboxylase, alpha subunit; Region: mdcA; TIGR01110
1400867005835	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
1400867005836	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1400867005837	The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432
1400867005838	dimerization interface [polypeptide binding]; other site
1400867005839	substrate binding pocket [chemical binding]; other site
1400867005840	ChrR Cupin-like domain; Region: Cupin_7; pfam12973
1400867005841	ChrR Cupin-like domain; Region: Cupin_7; pfam12973
1400867005842	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1400867005843	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1400867005844	putative substrate translocation pore; other site
1400867005845	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
1400867005846	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
1400867005847	Transcriptional regulator [Transcription]; Region: PaiB; COG2808
1400867005848	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
1400867005849	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1400867005850	DNA-binding site [nucleotide binding]; DNA binding site
1400867005851	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1400867005852	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1400867005853	homodimer interface [polypeptide binding]; other site
1400867005854	catalytic residue [active]
1400867005855	Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346
1400867005856	LrgA family; Region: LrgA; cl00608
1400867005857	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1400867005858	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1400867005859	The C-terminal substrate binding domain of LysR-like transcriptional regulator CidR, contains the type 2 periplasmic binding fold; Region: PBP2_CidR; cd08438
1400867005860	putative dimerization interface [polypeptide binding]; other site
1400867005861	glutathione S-transferase; Provisional; Region: PRK15113
1400867005862	Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of  glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570
1400867005863	C-terminal domain interface [polypeptide binding]; other site
1400867005864	GSH binding site (G-site) [chemical binding]; other site
1400867005865	dimer interface [polypeptide binding]; other site
1400867005866	C-terminal, alpha helical domain of an unknown subfamily 4 of Glutathione S-transferases; Region: GST_C_4; cd03195
1400867005867	putative dimer interface [polypeptide binding]; other site
1400867005868	N-terminal domain interface [polypeptide binding]; other site
1400867005869	putative substrate binding pocket (H-site) [chemical binding]; other site
1400867005870	putative S-transferase; Provisional; Region: PRK11752
1400867005871	GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048
1400867005872	C-terminal domain interface [polypeptide binding]; other site
1400867005873	GSH binding site (G-site) [chemical binding]; other site
1400867005874	dimer interface [polypeptide binding]; other site
1400867005875	C-terminal, alpha helical domain of Escherichia coli Yghu Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YghU_like; cd10292
1400867005876	dimer interface [polypeptide binding]; other site
1400867005877	N-terminal domain interface [polypeptide binding]; other site
1400867005878	active site
1400867005879	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1400867005880	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1400867005881	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472
1400867005882	putative effector binding pocket; other site
1400867005883	putative dimerization interface [polypeptide binding]; other site
1400867005884	short chain dehydrogenase; Provisional; Region: PRK12937
1400867005885	tetrahydroxynaphthalene/trihydroxynaphthalene reductase-like, classical (c) SDRs; Region: THN_reductase-like_SDR_c; cd05362
1400867005886	NADP binding site [chemical binding]; other site
1400867005887	homodimer interface [polypeptide binding]; other site
1400867005888	active site
1400867005889	substrate binding site [chemical binding]; other site
1400867005890	Member of the Rhodanese Homology Domain superfamily, subgroup 1. This CD includes the putative rhodanese-related sulfurtransferases of several uncharacterized proteins; Region: RHOD_1; cd01522
1400867005891	active site residue [active]
1400867005892	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
1400867005893	trimer interface [polypeptide binding]; other site
1400867005894	active site
1400867005895	substrate binding site [chemical binding]; other site
1400867005896	CoA binding site [chemical binding]; other site
1400867005897	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
1400867005898	Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453
1400867005899	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1400867005900	catalytic residue [active]
1400867005901	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
1400867005902	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1400867005903	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1400867005904	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
1400867005905	putative effector binding pocket; other site
1400867005906	dimerization interface [polypeptide binding]; other site
1400867005907	Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062
1400867005908	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1400867005909	substrate binding pocket [chemical binding]; other site
1400867005910	membrane-bound complex binding site; other site
1400867005911	hinge residues; other site
1400867005912	Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062
1400867005913	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1400867005914	substrate binding pocket [chemical binding]; other site
1400867005915	membrane-bound complex binding site; other site
1400867005916	hinge residues; other site
1400867005917	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
1400867005918	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
1400867005919	Walker A/P-loop; other site
1400867005920	ATP binding site [chemical binding]; other site
1400867005921	Q-loop/lid; other site
1400867005922	ABC transporter signature motif; other site
1400867005923	Walker B; other site
1400867005924	D-loop; other site
1400867005925	H-loop/switch region; other site
1400867005926	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1400867005927	dimer interface [polypeptide binding]; other site
1400867005928	conserved gate region; other site
1400867005929	putative PBP binding loops; other site
1400867005930	ABC-ATPase subunit interface; other site
1400867005931	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1400867005932	dimer interface [polypeptide binding]; other site
1400867005933	conserved gate region; other site
1400867005934	putative PBP binding loops; other site
1400867005935	ABC-ATPase subunit interface; other site
1400867005936	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1400867005937	Coenzyme A binding pocket [chemical binding]; other site
1400867005938	Response regulator receiver domain; Region: Response_reg; pfam00072
1400867005939	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1400867005940	active site
1400867005941	phosphorylation site [posttranslational modification]
1400867005942	intermolecular recognition site; other site
1400867005943	dimerization interface [polypeptide binding]; other site
1400867005944	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1400867005945	DNA binding residues [nucleotide binding]
1400867005946	dimerization interface [polypeptide binding]; other site
1400867005947	Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456
1400867005948	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1400867005949	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1400867005950	dimer interface [polypeptide binding]; other site
1400867005951	phosphorylation site [posttranslational modification]
1400867005952	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1400867005953	ATP binding site [chemical binding]; other site
1400867005954	Mg2+ binding site [ion binding]; other site
1400867005955	G-X-G motif; other site
1400867005956	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
1400867005957	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1400867005958	active site
1400867005959	phosphorylation site [posttranslational modification]
1400867005960	intermolecular recognition site; other site
1400867005961	dimerization interface [polypeptide binding]; other site
1400867005962	Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456
1400867005963	Na binding site [ion binding]; other site
1400867005964	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
1400867005965	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1400867005966	putative DNA binding site [nucleotide binding]; other site
1400867005967	putative Zn2+ binding site [ion binding]; other site
1400867005968	AsnC family; Region: AsnC_trans_reg; pfam01037
1400867005969	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
1400867005970	SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974
1400867005971	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
1400867005972	Catalytic site [active]
1400867005973	Stress-induced bacterial acidophilic repeat motif; Region: KGG; pfam10685
1400867005974	short chain dehydrogenase; Provisional; Region: PRK06701
1400867005975	classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355
1400867005976	NAD binding site [chemical binding]; other site
1400867005977	metal binding site [ion binding]; metal-binding site
1400867005978	active site
1400867005979	hydroperoxidase II; Provisional; Region: katE; PRK11249
1400867005980	Clade 2 of the heme-binding enzyme catalase; Region: catalase_clade_2; cd08155
1400867005981	tetramer interface [polypeptide binding]; other site
1400867005982	heme binding pocket [chemical binding]; other site
1400867005983	Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132
1400867005984	domain interactions; other site
1400867005985	Competence-damaged protein; Region: CinA; pfam02464
1400867005986	The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia.  This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775
1400867005987	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1400867005988	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1400867005989	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
1400867005990	putative effector binding pocket; other site
1400867005991	dimerization interface [polypeptide binding]; other site
1400867005992	SGNH_hydrolase subfamily, similar to the putative arylesterase/acylhydrolase from the rumen anaerobe Prevotella bryantii XynE. The P. bryantii XynE gene is located in a xylanase gene cluster. SGNH hydrolases are a diverse family of lipases and esterases; Region: XynE_like; cd01830
1400867005993	active site
1400867005994	catalytic triad [active]
1400867005995	oxyanion hole [active]
1400867005996	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
1400867005997	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1400867005998	S-adenosylmethionine binding site [chemical binding]; other site
1400867005999	AMP-binding domain protein; Validated; Region: PRK08315
1400867006000	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1400867006001	Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917
1400867006002	acyl-activating enzyme (AAE) consensus motif; other site
1400867006003	putative AMP binding site [chemical binding]; other site
1400867006004	putative active site [active]
1400867006005	putative CoA binding site [chemical binding]; other site
1400867006006	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1400867006007	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1400867006008	isovaleryl-CoA dehydrogenase; Region: PLN02519
1400867006009	Isovaleryl-CoA dehydrogenase; Region: IVD; cd01156
1400867006010	substrate binding site [chemical binding]; other site
1400867006011	FAD binding site [chemical binding]; other site
1400867006012	catalytic base [active]
1400867006013	3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820
1400867006014	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
1400867006015	enoyl-CoA hydratase; Provisional; Region: PRK05995
1400867006016	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
1400867006017	substrate binding site [chemical binding]; other site
1400867006018	oxyanion hole (OAH) forming residues; other site
1400867006019	trimer interface [polypeptide binding]; other site
1400867006020	Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770
1400867006021	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
1400867006022	ATP-grasp domain; Region: ATP-grasp_4; cl17255
1400867006023	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
1400867006024	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
1400867006025	carboxyltransferase (CT) interaction site; other site
1400867006026	biotinylation site [posttranslational modification]; other site
1400867006027	Isopropylmalate/homocitrate/citramalate synthases [Amino acid transport and metabolism]; Region: LeuA; COG0119
1400867006028	3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938
1400867006029	active site
1400867006030	catalytic residues [active]
1400867006031	metal binding site [ion binding]; metal-binding site
1400867006032	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1400867006033	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1400867006034	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
1400867006035	putative effector binding pocket; other site
1400867006036	dimerization interface [polypeptide binding]; other site
1400867006037	indolepyruvate ferredoxin oxidoreductase; Validated; Region: PRK09193
1400867006038	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
1400867006039	dimer interface [polypeptide binding]; other site
1400867006040	PYR/PP interface [polypeptide binding]; other site
1400867006041	TPP binding site [chemical binding]; other site
1400867006042	substrate binding site [chemical binding]; other site
1400867006043	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629
1400867006044	TPP-binding site [chemical binding]; other site
1400867006045	Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014
1400867006046	Thioesterase-like superfamily; Region: 4HBT_3; pfam13622
1400867006047	Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418
1400867006048	acyl-CoA dehydrogenase; Provisional; Region: PTZ00456
1400867006049	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
1400867006050	active site
1400867006051	Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806
1400867006052	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
1400867006053	CoenzymeA binding site [chemical binding]; other site
1400867006054	subunit interaction site [polypeptide binding]; other site
1400867006055	PHB binding site; other site
1400867006056	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1400867006057	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1400867006058	putative substrate translocation pore; other site
1400867006059	Maltoporin periplasmic N-terminal extension; Region: Sugarporin_N; pfam11471
1400867006060	3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428
1400867006061	3-oxoacid CoA-transferase, A subunit; Region: pcaI_scoA_fam; TIGR02429
1400867006062	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1400867006063	benzoate transport; Region: 2A0115; TIGR00895
1400867006064	putative substrate translocation pore; other site
1400867006065	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
1400867006066	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
1400867006067	active site
1400867006068	enoyl-CoA hydratase; Provisional; Region: PRK08138
1400867006069	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
1400867006070	substrate binding site [chemical binding]; other site
1400867006071	oxyanion hole (OAH) forming residues; other site
1400867006072	trimer interface [polypeptide binding]; other site
1400867006073	3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826
1400867006074	classical (c) SDRs; Region: SDR_c; cd05233
1400867006075	NAD(P) binding site [chemical binding]; other site
1400867006076	active site
1400867006077	3-hydroxy-acyl-CoA dehydrogenase; Validated; Region: PRK08268
1400867006078	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
1400867006079	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
1400867006080	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
1400867006081	acetyl-CoA acetyltransferase; Provisional; Region: PRK08131
1400867006082	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
1400867006083	dimer interface [polypeptide binding]; other site
1400867006084	active site
1400867006085	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
1400867006086	Transcriptional regulator [Transcription]; Region: IclR; COG1414
1400867006087	Bacterial transcriptional regulator; Region: IclR; pfam01614
1400867006088	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
1400867006089	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1400867006090	putative substrate translocation pore; other site
1400867006091	Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070
1400867006092	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
1400867006093	FMN binding site [chemical binding]; other site
1400867006094	substrate binding site [chemical binding]; other site
1400867006095	putative catalytic residue [active]
1400867006096	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
1400867006097	enoyl-CoA hydratase; Provisional; Region: PRK06688
1400867006098	substrate binding site [chemical binding]; other site
1400867006099	oxyanion hole (OAH) forming residues; other site
1400867006100	trimer interface [polypeptide binding]; other site
1400867006101	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
1400867006102	Transcriptional regulator [Transcription]; Region: IclR; COG1414
1400867006103	Bacterial transcriptional regulator; Region: IclR; pfam01614
1400867006104	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
1400867006105	CoA-transferase family III; Region: CoA_transf_3; pfam02515
1400867006106	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
1400867006107	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
1400867006108	active site
1400867006109	benzoate transport; Region: 2A0115; TIGR00895
1400867006110	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1400867006111	putative substrate translocation pore; other site
1400867006112	phosphonoacetaldehyde hydrolase; Provisional; Region: PRK13478
1400867006113	2-aminoethylphosphonate--pyruvate transaminase; Provisional; Region: PRK13479
1400867006114	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1400867006115	catalytic residue [active]
1400867006116	hydroxyglutarate oxidase; Provisional; Region: PRK11728
1400867006117	FAD dependent oxidoreductase TIGR03364; Region: HpnW_proposed
1400867006118	putative 2-aminoethylphosphonate ABC transporter, permease protein; Region: PhnU2; TIGR03262
1400867006119	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1400867006120	dimer interface [polypeptide binding]; other site
1400867006121	conserved gate region; other site
1400867006122	putative PBP binding loops; other site
1400867006123	ABC-ATPase subunit interface; other site
1400867006124	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1400867006125	dimer interface [polypeptide binding]; other site
1400867006126	conserved gate region; other site
1400867006127	putative PBP binding loops; other site
1400867006128	ABC-ATPase subunit interface; other site
1400867006129	putative 2-aminoethylphosphonate ABC transporter, ATP-binding protein; Region: PhnT2; TIGR03265
1400867006130	ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259
1400867006131	Walker A/P-loop; other site
1400867006132	ATP binding site [chemical binding]; other site
1400867006133	Q-loop/lid; other site
1400867006134	ABC transporter signature motif; other site
1400867006135	Walker B; other site
1400867006136	D-loop; other site
1400867006137	H-loop/switch region; other site
1400867006138	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
1400867006139	ABC-type thiamine transport system, periplasmic component [Coenzyme metabolism]; Region: TbpA; COG4143
1400867006140	transcriptional regulator protein; Region: phnR; TIGR03337
1400867006141	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1400867006142	DNA-binding site [nucleotide binding]; DNA binding site
1400867006143	UTRA domain; Region: UTRA; pfam07702
1400867006144	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
1400867006145	4-hydroxybenzoate 3-monooxygenase; Validated; Region: PRK08243
1400867006146	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
1400867006147	beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Region: pcaR_pcaU; TIGR02431
1400867006148	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
1400867006149	Bacterial transcriptional regulator; Region: IclR; pfam01614
1400867006150	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
1400867006151	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
1400867006152	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1400867006153	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1400867006154	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_6; cd08475
1400867006155	putative effector binding pocket; other site
1400867006156	putative dimerization interface [polypeptide binding]; other site
1400867006157	Carboxymuconolactone decarboxylase family; Region: CMD; cl00460
1400867006158	succinic semialdehyde dehydrogenase; Region: PLN02278
1400867006159	Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103
1400867006160	tetramerization interface [polypeptide binding]; other site
1400867006161	NAD(P) binding site [chemical binding]; other site
1400867006162	catalytic residues [active]
1400867006163	Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456
1400867006164	Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133
1400867006165	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
1400867006166	Uncharacterized Candidatus pelagibacter aldehyde dehydrogenase, DhaS-like; Region: ALDH_DhaS; cd07114
1400867006167	NAD(P) binding site [chemical binding]; other site
1400867006168	catalytic residues [active]
1400867006169	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
1400867006170	Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296
1400867006171	Flavin reductase like domain; Region: Flavin_Reduct; smart00903
1400867006172	Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303
1400867006173	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
1400867006174	Amino acid synthesis; Region: AA_synth; pfam06684
1400867006175	Transcriptional regulators [Transcription]; Region: GntR; COG1802
1400867006176	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1400867006177	DNA-binding site [nucleotide binding]; DNA binding site
1400867006178	FCD domain; Region: FCD; cl11656
1400867006179	Uncharacterized conserved protein [Function unknown]; Region: COG5470
1400867006180	Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038
1400867006181	Catalase-like heme-binding proteins similar to the uncharacterized srpA; Region: srpA_like; cd08153
1400867006182	putative heme binding pocket [chemical binding]; other site
1400867006183	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1400867006184	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1400867006185	Predicted ATP-dependent endonuclease of the OLD family [DNA replication, recombination, and repair]; Region: COG3593
1400867006186	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1400867006187	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1400867006188	Walker A/P-loop; other site
1400867006189	Walker A/P-loop; other site
1400867006190	ATP binding site [chemical binding]; other site
1400867006191	ATP binding site [chemical binding]; other site
1400867006192	TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family.  The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026
1400867006193	putative active site [active]
1400867006194	putative metal-binding site [ion binding]; other site
1400867006195	UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580
1400867006196	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
1400867006197	RT_Bac_retron_II: Reverse transcriptases (RTs) in bacterial retrotransposons or retrons. The polymerase reaction of this enzyme leads to the production of a unique RNA-DNA complex called msDNA (multicopy single-stranded (ss)DNA) in which a small ssDNA...; Region: RT_Bac_retron_II; cd03487
1400867006198	putative active site [active]
1400867006199	putative NTP binding site [chemical binding]; other site
1400867006200	putative nucleic acid binding site [nucleotide binding]; other site
1400867006201	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
1400867006202	CoenzymeA binding site [chemical binding]; other site
1400867006203	subunit interaction site [polypeptide binding]; other site
1400867006204	PHB binding site; other site
1400867006205	phenylacetic acid degradation protein PaaY; Region: PaaY; TIGR02287
1400867006206	paaY-like: This group is composed by uncharacterized proteins with similarity to the protein product of the E. coli paaY gene, which is part of the paa gene cluster responsible for phenylacetic acid degradation. Proteins in this group are expected to...; Region: LbH_paaY_like; cd04745
1400867006207	putative trimer interface [polypeptide binding]; other site
1400867006208	putative metal binding site [ion binding]; other site
1400867006209	PaaX-like protein; Region: PaaX; pfam07848
1400867006210	phenylacetic acid degradation operon negative regulatory protein PaaX; Region: PaaX_trns_reg; TIGR02277
1400867006211	PaaX-like protein C-terminal domain; Region: PaaX_C; pfam08223
1400867006212	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1400867006213	phenylacetate-CoA ligase; Region: PA_CoA_ligase; TIGR02155
1400867006214	acyl-activating enzyme (AAE) consensus motif; other site
1400867006215	AMP binding site [chemical binding]; other site
1400867006216	active site
1400867006217	CoA binding site [chemical binding]; other site
1400867006218	beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050
1400867006219	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
1400867006220	dimer interface [polypeptide binding]; other site
1400867006221	active site
1400867006222	3-hydroxy-acyl-CoA dehydrogenase; Validated; Region: PRK08268
1400867006223	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
1400867006224	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
1400867006225	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
1400867006226	enoyl-CoA hydratase; Provisional; Region: PRK08140
1400867006227	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
1400867006228	substrate binding site [chemical binding]; other site
1400867006229	oxyanion hole (OAH) forming residues; other site
1400867006230	trimer interface [polypeptide binding]; other site
1400867006231	enoyl-CoA hydratase-isomerase; Provisional; Region: PRK09674
1400867006232	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
1400867006233	substrate binding site [chemical binding]; other site
1400867006234	oxyanion hole (OAH) forming residues; other site
1400867006235	trimer interface [polypeptide binding]; other site
1400867006236	phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160
1400867006237	NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214
1400867006238	FAD binding pocket [chemical binding]; other site
1400867006239	FAD binding motif [chemical binding]; other site
1400867006240	phosphate binding motif [ion binding]; other site
1400867006241	beta-alpha-beta structure motif; other site
1400867006242	NAD(p) ribose binding residues [chemical binding]; other site
1400867006243	NAD binding pocket [chemical binding]; other site
1400867006244	NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site
1400867006245	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
1400867006246	catalytic loop [active]
1400867006247	iron binding site [ion binding]; other site
1400867006248	Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151
1400867006249	phenylacetate-CoA oxygenase, PaaJ subunit; Region: PA_CoA_Oxy4; TIGR02159
1400867006250	Phenylacetic acid catabolic protein; Region: PaaA_PaaC; pfam05138
1400867006251	phenylacetate-CoA oxygenase subunit PaaB; Provisional; Region: paaB; PRK13781
1400867006252	phenylacetate-CoA oxygenase subunit PaaA; Provisional; Region: paaA; PRK13778
1400867006253	phenylacetate-CoA oxygenase, PaaG subunit; Region: PA_CoA_Oxy1; TIGR02156
1400867006254	bifunctional aldehyde dehydrogenase/enoyl-CoA hydratase; Provisional; Region: PRK11563
1400867006255	N-terminal domain of the monoamine oxidase C dehydratase; Region: ALDH_MaoC-N; cd07128
1400867006256	substrate binding site [chemical binding]; other site
1400867006257	dimer interface [polypeptide binding]; other site
1400867006258	NADP binding site [chemical binding]; other site
1400867006259	catalytic residues [active]
1400867006260	MaoC_C  The C-terminal hot dog fold of the MaoC (monoamine oxidase C) dehydratase regulatory protein. Orthologs of MaoC include PaaZ [Escherichia coli] and PaaN [Pseudomonas putida], which are putative ring-opening enzymes involved in phenylacetic acid...; Region: MaoC_C; cd03452
1400867006261	substrate binding site [chemical binding]; other site
1400867006262	L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720
1400867006263	Serine dehydratase beta chain; Region: SDH_beta; pfam03315
1400867006264	Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313
1400867006265	amino acid transporter; Region: 2A0306; TIGR00909
1400867006266	NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012
1400867006267	Alpha-Ketoglutaric Semialdehyde Dehydrogenase; Region: ALDH_KGSADH; cd07129
1400867006268	dimer interface [polypeptide binding]; other site
1400867006269	NADP binding site [chemical binding]; other site
1400867006270	catalytic residues [active]
1400867006271	metabolite-proton symporter; Region: 2A0106; TIGR00883
1400867006272	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1400867006273	putative substrate translocation pore; other site
1400867006274	PAS fold; Region: PAS_4; pfam08448
1400867006275	Helix-turn-helix domain; Region: HTH_18; pfam12833
1400867006276	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1400867006277	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992
1400867006278	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510
1400867006279	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
1400867006280	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
1400867006281	hydroxyproline-2-epimerase; Provisional; Region: PRK13970
1400867006282	hydroxyproline-2-epimerase; Provisional; Region: PRK13971
1400867006283	Transcriptional regulators [Transcription]; Region: GntR; COG1802
1400867006284	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1400867006285	DNA-binding site [nucleotide binding]; DNA binding site
1400867006286	FCD domain; Region: FCD; pfam07729
1400867006287	EamA-like transporter family; Region: EamA; pfam00892
1400867006288	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
1400867006289	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
1400867006290	Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408
1400867006291	inhibitor site; inhibition site
1400867006292	active site
1400867006293	dimer interface [polypeptide binding]; other site
1400867006294	catalytic residue [active]
1400867006295	Putative hemolysin [General function prediction only]; Region: Hlx; COG3042
1400867006296	Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139
1400867006297	Domain of unknown function (DUF333); Region: DUF333; pfam03891
1400867006298	Peptidase inhibitor I78 family; Region: Inhibitor_I78; pfam11720
1400867006299	redox-sensitive transcriptional activator SoxR; Region: SoxR; TIGR01950
1400867006300	Helix-Turn-Helix DNA binding domain of the SoxR transcription regulator; Region: HTH_SoxR; cd01110
1400867006301	DNA binding residues [nucleotide binding]
1400867006302	dimer interface [polypeptide binding]; other site
1400867006303	[2Fe-2S] cluster binding site [ion binding]; other site
1400867006304	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1636
1400867006305	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
1400867006306	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1400867006307	Coenzyme A binding pocket [chemical binding]; other site
1400867006308	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214
1400867006309	Protein of unknown function (DUF1006); Region: DUF1006; pfam06224
1400867006310	putative cyanate transporter; Provisional; Region: cynX; PRK09705
1400867006311	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1400867006312	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
1400867006313	nucleoside/Zn binding site; other site
1400867006314	dimer interface [polypeptide binding]; other site
1400867006315	catalytic motif [active]
1400867006316	Ankyrin repeats (many copies); Region: Ank_4; pfam13637
1400867006317	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
1400867006318	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
1400867006319	Ankyrin repeats (many copies); Region: Ank_4; pfam13637
1400867006320	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1400867006321	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1400867006322	LysR substrate binding domain; Region: LysR_substrate; pfam03466
1400867006323	dimerization interface [polypeptide binding]; other site
1400867006324	D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557
1400867006325	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_M15_4; pfam13539
1400867006326	type IV / VI secretion system protein, DotU family; Region: IV_VI_DotU; TIGR03349
1400867006327	type VI secretion protein, VC_A0114 family; Region: VI_chp_4; TIGR03353
1400867006328	Bacterial protein of unknown function (DUF876); Region: DUF876; pfam05936
1400867006329	type VI secretion-associated protein, ImpA family; Region: VI_chp_8; TIGR03363
1400867006330	ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812
1400867006331	type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345
1400867006332	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1400867006333	Walker A motif; other site
1400867006334	ATP binding site [chemical binding]; other site
1400867006335	Walker B motif; other site
1400867006336	arginine finger; other site
1400867006337	JNK_SAPK-associated protein-1; Region: Jnk-SapK_ap_N; pfam09744
1400867006338	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1400867006339	Walker A motif; other site
1400867006340	ATP binding site [chemical binding]; other site
1400867006341	Walker B motif; other site
1400867006342	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
1400867006343	PAAR motif; Region: PAAR_motif; pfam05488
1400867006344	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
1400867006345	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
1400867006346	ligand binding site [chemical binding]; other site
1400867006347	Uncharacterized protein conserved in bacteria (DUF2094); Region: DUF2094; cl01611
1400867006348	Type VI protein secretion system component VasK [Intracellular trafficking, secretion, and    vesicular transport]; Region: IcmF; COG3523
1400867006349	Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761
1400867006350	Protein of unknown function (DUF1215); Region: DUF1215; pfam06744
1400867006351	Protein of unknown function (DUF1305); Region: DUF1305; pfam06996
1400867006352	Type VI protein secretion system component VasA [Intracellular trafficking, secretion, and    vesicular transport]; Region: COG3519
1400867006353	type VI secretion protein, VC_A0110 family; Region: VI_chp_6; TIGR03359
1400867006354	type VI secretion system lysozyme-like protein; Region: VI_zyme; TIGR03357
1400867006355	Protein of unknown function (DUF796); Region: DUF796; pfam05638
1400867006356	Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and    vesicular transport]; Region: COG3517; cl05484
1400867006357	Protein of unknown function (DUF877); Region: DUF877; pfam05943
1400867006358	Protein of unknown function (DUF770); Region: DUF770; pfam05591
1400867006359	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
1400867006360	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
1400867006361	Sel1-like repeats; Region: SEL1; smart00671
1400867006362	Sel1-like repeats; Region: SEL1; smart00671
1400867006363	Sel1-like repeats; Region: SEL1; smart00671
1400867006364	Sel1-like repeats; Region: SEL1; smart00671
1400867006365	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
1400867006366	Domain of unknown function (DUF4123); Region: DUF4123; pfam13503
1400867006367	Uncharacterized protein conserved in bacteria [Function unknown]; Region: VgrG; COG3501
1400867006368	Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954
1400867006369	Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717
1400867006370	Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296
1400867006371	Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; pfam10106
1400867006372	Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954
1400867006373	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
1400867006374	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1400867006375	dimer interface [polypeptide binding]; other site
1400867006376	conserved gate region; other site
1400867006377	putative PBP binding loops; other site
1400867006378	ABC-ATPase subunit interface; other site
1400867006379	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
1400867006380	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
1400867006381	Walker A/P-loop; other site
1400867006382	ATP binding site [chemical binding]; other site
1400867006383	Q-loop/lid; other site
1400867006384	ABC transporter signature motif; other site
1400867006385	Walker B; other site
1400867006386	D-loop; other site
1400867006387	H-loop/switch region; other site
1400867006388	ABC transporter periplasmic binding protein, urea carboxylase region; Region: ABC_peri_uca; TIGR03427
1400867006389	allophanate hydrolase; Provisional; Region: PRK08186
1400867006390	Amidase; Region: Amidase; cl11426
1400867006391	nickel responsive regulator; Provisional; Region: PRK04460
1400867006392	NikR C terminal nickel binding domain; Region: NikR_C; pfam08753
1400867006393	Predicted transcriptional regulators [Transcription]; Region: COG1733
1400867006394	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1400867006395	putative DNA binding site [nucleotide binding]; other site
1400867006396	putative Zn2+ binding site [ion binding]; other site
1400867006397	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
1400867006398	urea carboxylase; Region: urea_carbox; TIGR02712
1400867006399	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
1400867006400	ATP-grasp domain; Region: ATP-grasp_4; cl17255
1400867006401	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
1400867006402	Allophanate hydrolase subunit 2; Region: AHS2; smart00797
1400867006403	Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896
1400867006404	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
1400867006405	carboxyltransferase (CT) interaction site; other site
1400867006406	biotinylation site [posttranslational modification]; other site
1400867006407	urea carboxylase-associated protein 1; Region: urea_degr_1; TIGR03424
1400867006408	Domain of unknown function (DUF1989); Region: DUF1989; pfam09347
1400867006409	urea carboxylase-associated protein 1; Region: urea_degr_1; TIGR03424
1400867006410	urea carboxylase-associated protein 2; Region: urea_degr_2; TIGR03425
1400867006411	Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283
1400867006412	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
1400867006413	NAD binding site [chemical binding]; other site
1400867006414	catalytic Zn binding site [ion binding]; other site
1400867006415	structural Zn binding site [ion binding]; other site
1400867006416	Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821
1400867006417	putative hydrophobic ligand binding site [chemical binding]; other site
1400867006418	protein interface [polypeptide binding]; other site
1400867006419	gate; other site
1400867006420	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1400867006421	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1400867006422	Herpesvirus egress protein UL20; Region: Herpes_UL20; pfam04544
1400867006423	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
1400867006424	Sel1-like repeats; Region: SEL1; smart00671
1400867006425	Sel1-like repeats; Region: SEL1; smart00671
1400867006426	Sel1-like repeats; Region: SEL1; smart00671
1400867006427	Sel1-like repeats; Region: SEL1; smart00671
1400867006428	Sel1-like repeats; Region: SEL1; smart00671
1400867006429	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
1400867006430	ClC sycA-like chloride channel proteins. This ClC family presents in bacteria, where it facilitates acid resistance in acidic soil. Mutation of this gene (sycA) in Rhizobium tropici CIAT899 causes serious deficiencies in nodule development, nodulation...; Region: ClC_sycA_like; cd03682
1400867006431	putative Cl- selectivity filter; other site
1400867006432	putative pore gating glutamate residue; other site
1400867006433	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
1400867006434	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
1400867006435	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
1400867006436	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
1400867006437	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
1400867006438	carboxyltransferase (CT) interaction site; other site
1400867006439	biotinylation site [posttranslational modification]; other site
1400867006440	Allophanate hydrolase subunit 1; Region: AHS1; pfam02682
1400867006441	Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049
1400867006442	Allophanate hydrolase subunit 2; Region: AHS2; pfam02626
1400867006443	hypothetical protein; Provisional; Region: PRK05463
1400867006444	LamB/YcsF family of  lactam utilization protein; Region: LamB_YcsF_like; cd10787
1400867006445	putative active site [active]
1400867006446	Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914
1400867006447	transcriptional regulator, ArgP family; Region: argP; TIGR03298
1400867006448	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1400867006449	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
1400867006450	dimerization interface [polypeptide binding]; other site
1400867006451	Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354
1400867006452	Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508
1400867006453	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
1400867006454	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
1400867006455	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
1400867006456	Helix-Turn-Helix DNA binding domain of the transcription regulators NolA and AlbR; Region: HTH_NolA-AlbR; cd04788
1400867006457	DNA binding residues [nucleotide binding]
1400867006458	putative dimer interface [polypeptide binding]; other site
1400867006459	TipAS antibiotic-recognition domain; Region: TipAS; pfam07739
1400867006460	TipAS antibiotic-recognition domain; Region: TipAS; pfam07739
1400867006461	Uncharacterized protein conserved in bacteria (DUF2147); Region: DUF2147; pfam09917
1400867006462	benzoate transport; Region: 2A0115; TIGR00895
1400867006463	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1400867006464	putative substrate translocation pore; other site
1400867006465	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1400867006466	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1400867006467	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1400867006468	Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598
1400867006469	metal ion transporter CorA-like divalent cation transporter superfamily; Region: MIT_CorA-like; cl00459
1400867006470	oligomer interface [polypeptide binding]; other site
1400867006471	Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279
1400867006472	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
1400867006473	putative acyl-acceptor binding pocket; other site
1400867006474	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
1400867006475	Threonine/homoserine efflux transporter [Amino acid transport and metabolism]; Region: rhtA; COG5006
1400867006476	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
1400867006477	AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404
1400867006478	AsnC family; Region: AsnC_trans_reg; pfam01037
1400867006479	DNA mismatch repair protein MutS; Provisional; Region: PRK05399
1400867006480	MutS domain I; Region: MutS_I; pfam01624
1400867006481	MutS domain II; Region: MutS_II; pfam05188
1400867006482	MutS domain III; Region: MutS_III; pfam05192
1400867006483	MutS domain V; Region: MutS_V; pfam00488
1400867006484	Walker A/P-loop; other site
1400867006485	ATP binding site [chemical binding]; other site
1400867006486	Q-loop/lid; other site
1400867006487	ABC transporter signature motif; other site
1400867006488	Walker B; other site
1400867006489	D-loop; other site
1400867006490	H-loop/switch region; other site
1400867006491	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
1400867006492	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1400867006493	Coenzyme A binding pocket [chemical binding]; other site
1400867006494	Ferredoxin [Energy production and conversion]; Region: COG1146
1400867006495	4Fe-4S binding domain; Region: Fer4; cl02805
1400867006496	Domain of unknown function (DUF3470); Region: DUF3470; pfam11953
1400867006497	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3108
1400867006498	Predicted O-methyltransferase [General function prediction only]; Region: COG4122
1400867006499	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
1400867006500	S-adenosylmethionine binding site [chemical binding]; other site
1400867006501	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
1400867006502	Ligand Binding Site [chemical binding]; other site
1400867006503	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cd00208
1400867006504	Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110
1400867006505	putative trimer interface [polypeptide binding]; other site
1400867006506	Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647
1400867006507	trimer interface [polypeptide binding]; other site
1400867006508	active site
1400867006509	substrate binding site [chemical binding]; other site
1400867006510	putative CoA binding site [chemical binding]; other site
1400867006511	CoA binding site [chemical binding]; other site
1400867006512	Uncharacterized conserved protein [Function unknown]; Region: COG1739
1400867006513	Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205
1400867006514	type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843
1400867006515	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
1400867006516	HlyD family secretion protein; Region: HlyD_3; pfam13437
1400867006517	type I secretion system ATPase, LssB family; Region: type_I_sec_LssB; TIGR03375
1400867006518	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1400867006519	ATP-binding cassette domain of bacteriocin exporters, subfamily C; Region: ABCC_bacteriocin_exporters; cd03245
1400867006520	Walker A/P-loop; other site
1400867006521	ATP binding site [chemical binding]; other site
1400867006522	Q-loop/lid; other site
1400867006523	ABC transporter signature motif; other site
1400867006524	Walker B; other site
1400867006525	D-loop; other site
1400867006526	H-loop/switch region; other site
1400867006527	type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844
1400867006528	ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137
1400867006529	ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218
1400867006530	Walker A/P-loop; other site
1400867006531	ATP binding site [chemical binding]; other site
1400867006532	Q-loop/lid; other site
1400867006533	ABC transporter signature motif; other site
1400867006534	Walker B; other site
1400867006535	D-loop; other site
1400867006536	H-loop/switch region; other site
1400867006537	lipopolysaccharide transport periplasmic protein LptA; Region: outer_YhbN_LptA; TIGR03002
1400867006538	OstA-like protein; Region: OstA; pfam03968
1400867006539	Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835
1400867006540	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3117; cl01200
1400867006541	HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662
1400867006542	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1400867006543	active site
1400867006544	motif I; other site
1400867006545	motif II; other site
1400867006546	D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892
1400867006547	KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014
1400867006548	putative active site [active]
1400867006549	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein.  These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604
1400867006550	cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260
1400867006551	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
1400867006552	active site
1400867006553	HIGH motif; other site
1400867006554	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
1400867006555	KMSKS motif; other site
1400867006556	Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963
1400867006557	tRNA binding surface [nucleotide binding]; other site
1400867006558	anticodon binding site; other site
1400867006559	Domain of unknown function (DUF4142); Region: DUF4142; pfam13628
1400867006560	Predicted transcriptional regulators [Transcription]; Region: COG1733
1400867006561	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
1400867006562	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1400867006563	putative substrate translocation pore; other site
1400867006564	Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072
1400867006565	pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880
1400867006566	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232
1400867006567	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
1400867006568	DNA-binding site [nucleotide binding]; DNA binding site
1400867006569	RNA-binding motif; other site
1400867006570	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
1400867006571	Glycosyl hydrolase 108; Region: Glyco_hydro_108; pfam05838
1400867006572	Predicted Peptidoglycan domain; Region: PG_binding_3; pfam09374
1400867006573	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1400867006574	Predicted transcriptional regulator [Transcription]; Region: COG2932
1400867006575	non-specific DNA binding site [nucleotide binding]; other site
1400867006576	salt bridge; other site
1400867006577	sequence-specific DNA binding site [nucleotide binding]; other site
1400867006578	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
1400867006579	Catalytic site [active]
1400867006580	exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286
1400867006581	ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489
1400867006582	generic binding surface II; other site
1400867006583	generic binding surface I; other site
1400867006584	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
1400867006585	Cysteine-rich 4 helical bundle widely conserved in bacteria; Region: DUF326; cd08026
1400867006586	dimerization interface [polypeptide binding]; other site
1400867006587	Glutathione-dependent formaldehyde-activating enzyme; Region: GFA; pfam04828
1400867006588	Cu(I)-responsive transcriptional regulator; Region: CueR; TIGR02044
1400867006589	Helix-Turn-Helix DNA binding domain of CueR-like transcription regulators; Region: HTH_CueR; cd01108
1400867006590	DNA binding residues [nucleotide binding]
1400867006591	dimer interface [polypeptide binding]; other site
1400867006592	copper binding site [ion binding]; other site
1400867006593	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
1400867006594	metal-binding site [ion binding]
1400867006595	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
1400867006596	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
1400867006597	metal-binding site [ion binding]
1400867006598	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
1400867006599	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1400867006600	motif II; other site
1400867006601	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
1400867006602	metal-binding site [ion binding]
1400867006603	DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906
1400867006604	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1400867006605	The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in benzoate catabolism; contains the type 2 periplasmic binding fold; Region: PBP2_BenM_CatM_CatR; cd08445
1400867006606	dimerizarion interface [polypeptide binding]; other site
1400867006607	CrgA pocket; other site
1400867006608	substrate binding pocket [chemical binding]; other site
1400867006609	benzoate 1,2-dioxygenase, large subunit; Region: benzo_1_2_benA; TIGR03229
1400867006610	Rieske non-heme iron oxygenase (RO) family, 2-Halobenzoate 1,2-dioxygenase (HBDO) subfamily, N-terminal Rieske domain of the oxygenase alpha subunit; ROs comprise a large class of aromatic ring-hydroxylating dioxygenases that enable microorganisms to...; Region: Rieske_RO_Alpha_HBDO; cd03542
1400867006611	C-terminal catalytic domain of the oxygenase alpha subunit of Pseudomonas resinovorans strain CA10 anthranilate 1,2-dioxygenase and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_AntDO-like; cd08879
1400867006612	putative alpha subunit interface [polypeptide binding]; other site
1400867006613	putative active site [active]
1400867006614	putative substrate binding site [chemical binding]; other site
1400867006615	Fe binding site [ion binding]; other site
1400867006616	Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667
1400867006617	inter-subunit interface; other site
1400867006618	anthranilate dioxygenase reductase; Provisional; Region: antC; PRK11872
1400867006619	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
1400867006620	catalytic loop [active]
1400867006621	iron binding site [ion binding]; other site
1400867006622	Benzoate dioxygenase reductase (BenDO) FAD/NAD binding domain. Oxygenases oxidize hydrocarbons using dioxygen as the oxidant. As a Class I bacterial dioxygenases, benzoate dioxygenase like proteins combine an [2Fe-2S] cluster containing N-terminal...; Region: BenDO_FAD_NAD; cd06209
1400867006623	FAD binding pocket [chemical binding]; other site
1400867006624	FAD binding motif [chemical binding]; other site
1400867006625	phosphate binding motif [ion binding]; other site
1400867006626	beta-alpha-beta structure motif; other site
1400867006627	NAD binding pocket [chemical binding]; other site
1400867006628	1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate dehydrogenase; Provisional; Region: benD; PRK12823
1400867006629	1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate dehydrogenase (DHB DH)-like, classical (c) SDR; Region: DHB_DH-like_SDR_c; cd08937
1400867006630	putative NAD(P) binding site [chemical binding]; other site
1400867006631	active site
1400867006632	benzoate transporter; Region: benE; TIGR00843
1400867006633	Benzoate membrane transport protein; Region: BenE; pfam03594
1400867006634	benzoate transport; Region: 2A0115; TIGR00895
1400867006635	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1400867006636	putative substrate translocation pore; other site
1400867006637	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1400867006638	putative substrate translocation pore; other site
1400867006639	outer membrane porin, OprD family; Region: OprD; pfam03573
1400867006640	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK07515
1400867006641	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
1400867006642	dimer interface [polypeptide binding]; other site
1400867006643	active site
1400867006644	CoA binding pocket [chemical binding]; other site
1400867006645	ATP-dependent helicase HrpA; Region: DEAH_box_HrpA; TIGR01967
1400867006646	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1400867006647	ATP binding site [chemical binding]; other site
1400867006648	putative Mg++ binding site [ion binding]; other site
1400867006649	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1400867006650	nucleotide binding region [chemical binding]; other site
1400867006651	ATP-binding site [chemical binding]; other site
1400867006652	Helicase associated domain (HA2); Region: HA2; pfam04408
1400867006653	Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717
1400867006654	Domain of unknown function (DUF3418); Region: DUF3418; pfam11898
1400867006655	peroxiredoxin; Region: AhpC; TIGR03137
1400867006656	Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015
1400867006657	dimer interface [polypeptide binding]; other site
1400867006658	decamer (pentamer of dimers) interface [polypeptide binding]; other site
1400867006659	catalytic triad [active]
1400867006660	peroxidatic and resolving cysteines [active]
1400867006661	KTSC domain; Region: KTSC; pfam13619
1400867006662	Predicted O-methyltransferase [General function prediction only]; Region: COG4122
1400867006663	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1400867006664	S-adenosylmethionine binding site [chemical binding]; other site
1400867006665	Protein of unknown function (DUF1653); Region: DUF1653; pfam07866
1400867006666	alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317
1400867006667	Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974
1400867006668	catalytic residue [active]
1400867006669	TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026
1400867006670	catalytic residues [active]
1400867006671	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1400867006672	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1400867006673	glutathionine S-transferase; Provisional; Region: PRK10542
1400867006674	GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057
1400867006675	C-terminal domain interface [polypeptide binding]; other site
1400867006676	GSH binding site (G-site) [chemical binding]; other site
1400867006677	dimer interface [polypeptide binding]; other site
1400867006678	C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188
1400867006679	dimer interface [polypeptide binding]; other site
1400867006680	N-terminal domain interface [polypeptide binding]; other site
1400867006681	substrate binding pocket (H-site) [chemical binding]; other site
1400867006682	Predicted extracellular nuclease [General function prediction only]; Region: COG2374
1400867006683	YhcR_OBF_like: A subfamily of OB-fold domains similar to the OB folds of Bacillus subtilis YhcR. YhcR is a sugar-nonspecific nuclease, which is active in the presence of Ca2+ and Mn2+. It cleaves RNA endonucleolytically, producing 3'-monophosphate...; Region: YhcR_OBF_like; cd04486
1400867006684	generic binding surface II; other site
1400867006685	generic binding surface I; other site
1400867006686	Mycoplasma pulmonis MnuA nuclease-like; Region: MnuA_DNase1-like; cd10283
1400867006687	putative active site [active]
1400867006688	putative catalytic site [active]
1400867006689	putative Mg binding site IVb [ion binding]; other site
1400867006690	putative phosphate binding site [ion binding]; other site
1400867006691	putative DNA binding site [nucleotide binding]; other site
1400867006692	putative Mg binding site IVa [ion binding]; other site
1400867006693	tRNA (guanine-N(7)-)-methyltransferase; Reviewed; Region: trmB; PRK00121
1400867006694	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
1400867006695	GST_N family, unknown subfamily 2; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_2; cd03047
1400867006696	putative C-terminal domain interface [polypeptide binding]; other site
1400867006697	putative GSH binding site (G-site) [chemical binding]; other site
1400867006698	putative dimer interface [polypeptide binding]; other site
1400867006699	C-terminal, alpha helical domain of an unknown subfamily 2 of Glutathione S-transferases; Region: GST_C_2; cd03180
1400867006700	putative N-terminal domain interface [polypeptide binding]; other site
1400867006701	putative dimer interface [polypeptide binding]; other site
1400867006702	putative substrate binding pocket (H-site) [chemical binding]; other site
1400867006703	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807
1400867006704	Domain of unknown function (DUF2520); Region: DUF2520; pfam10728
1400867006705	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
1400867006706	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
1400867006707	ligand binding site [chemical binding]; other site
1400867006708	dihydroorotase; Validated; Region: pyrC; PRK09357
1400867006709	Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317
1400867006710	active site
1400867006711	aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856
1400867006712	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
1400867006713	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
1400867006714	23S rRNA m(2)G2445 methyltransferase; Provisional; Region: rlmL; PRK11783
1400867006715	THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715
1400867006716	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
1400867006717	DNA methylase; Region: N6_N4_Mtase; cl17433
1400867006718	Competence-damaged protein; Region: CinA; pfam02464
1400867006719	ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346
1400867006720	Clp amino terminal domain; Region: Clp_N; pfam02861
1400867006721	Clp amino terminal domain; Region: Clp_N; pfam02861
1400867006722	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1400867006723	Walker A motif; other site
1400867006724	ATP binding site [chemical binding]; other site
1400867006725	Walker B motif; other site
1400867006726	arginine finger; other site
1400867006727	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1400867006728	Walker A motif; other site
1400867006729	ATP binding site [chemical binding]; other site
1400867006730	Walker B motif; other site
1400867006731	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
1400867006732	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
1400867006733	Peptidase family M23; Region: Peptidase_M23; pfam01551
1400867006734	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1400867006735	Coenzyme A binding pocket [chemical binding]; other site
1400867006736	OsmC-like protein; Region: OsmC; cl00767
1400867006737	DNA-binding transcriptional dual regulator Crp; Provisional; Region: PRK11753
1400867006738	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
1400867006739	ligand binding site [chemical binding]; other site
1400867006740	flexible hinge region; other site
1400867006741	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
1400867006742	putative switch regulator; other site
1400867006743	non-specific DNA interactions [nucleotide binding]; other site
1400867006744	DNA binding site [nucleotide binding]
1400867006745	sequence specific DNA binding site [nucleotide binding]; other site
1400867006746	putative cAMP binding site [chemical binding]; other site
1400867006747	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1400867006748	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
1400867006749	active site
1400867006750	catalytic tetrad [active]
1400867006751	Peptidase family M48; Region: Peptidase_M48; pfam01435
1400867006752	Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788
1400867006753	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
1400867006754	Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108
1400867006755	ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: PRK12421
1400867006756	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
1400867006757	dimer interface [polypeptide binding]; other site
1400867006758	motif 1; other site
1400867006759	active site
1400867006760	motif 2; other site
1400867006761	motif 3; other site
1400867006762	Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057
1400867006763	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846
1400867006764	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
1400867006765	alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252
1400867006766	Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673
1400867006767	motif 1; other site
1400867006768	active site
1400867006769	motif 2; other site
1400867006770	motif 3; other site
1400867006771	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
1400867006772	DHHA1 domain; Region: DHHA1; pfam02272
1400867006773	aspartate kinase; Reviewed; Region: PRK06635
1400867006774	AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261
1400867006775	putative nucleotide binding site [chemical binding]; other site
1400867006776	putative catalytic residues [active]
1400867006777	putative Mg ion binding site [ion binding]; other site
1400867006778	putative aspartate binding site [chemical binding]; other site
1400867006779	ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913
1400867006780	putative allosteric regulatory site; other site
1400867006781	ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936
1400867006782	carbon storage regulator; Provisional; Region: PRK01712
1400867006783	bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182
1400867006784	RNA/DNA hybrid binding site [nucleotide binding]; other site
1400867006785	active site
1400867006786	Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038
1400867006787	Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816
1400867006788	Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320
1400867006789	active site
1400867006790	purine riboside binding site [chemical binding]; other site
1400867006791	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
1400867006792	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
1400867006793	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
1400867006794	classical (c) SDRs; Region: SDR_c; cd05233
1400867006795	short chain dehydrogenase; Provisional; Region: PRK05650
1400867006796	NAD(P) binding site [chemical binding]; other site
1400867006797	active site
1400867006798	Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118
1400867006799	Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687
1400867006800	Pirin-related protein [General function prediction only]; Region: COG1741
1400867006801	Pirin; Region: Pirin; pfam02678
1400867006802	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1400867006803	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1400867006804	Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118
1400867006805	Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687
1400867006806	classical (c) SDRs; Region: SDR_c; cd05233
1400867006807	short chain dehydrogenase; Provisional; Region: PRK05650
1400867006808	NAD(P) binding site [chemical binding]; other site
1400867006809	active site
1400867006810	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
1400867006811	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
1400867006812	O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315
1400867006813	Leucine carboxyl methyltransferase; Region: LCM; pfam04072
1400867006814	Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625
1400867006815	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1400867006816	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1400867006817	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
1400867006818	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
1400867006819	short chain dehydrogenase; Provisional; Region: PRK06181
1400867006820	classical (c) SDRs; Region: SDR_c; cd05233
1400867006821	NAD(P) binding site [chemical binding]; other site
1400867006822	active site
1400867006823	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
1400867006824	Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303
1400867006825	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
1400867006826	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
1400867006827	outer membrane porin, OprD family; Region: OprD; pfam03573
1400867006828	benzoate transport; Region: 2A0115; TIGR00895
1400867006829	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1400867006830	putative substrate translocation pore; other site
1400867006831	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1400867006832	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
1400867006833	Sulfatase; Region: Sulfatase; pfam00884
1400867006834	Uncharacterized conserved protein [Function unknown]; Region: COG1262
1400867006835	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
1400867006836	outer membrane porin, OprD family; Region: OprD; pfam03573
1400867006837	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
1400867006838	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938
1400867006839	iron-sulfur cluster [ion binding]; other site
1400867006840	[2Fe-2S] cluster binding site [ion binding]; other site
1400867006841	C-terminal catalytic domain of the oxygenase alpha subunit of dicamba O-demethylase and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_DMO-like; cd08878
1400867006842	alpha subunit interface [polypeptide binding]; other site
1400867006843	active site
1400867006844	substrate binding site [chemical binding]; other site
1400867006845	Fe binding site [ion binding]; other site
1400867006846	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
1400867006847	Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal  ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185
1400867006848	FMN-binding pocket [chemical binding]; other site
1400867006849	flavin binding motif; other site
1400867006850	phosphate binding motif [ion binding]; other site
1400867006851	beta-alpha-beta structure motif; other site
1400867006852	NAD binding pocket [chemical binding]; other site
1400867006853	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
1400867006854	catalytic loop [active]
1400867006855	iron binding site [ion binding]; other site
1400867006856	Transcriptional regulators [Transcription]; Region: GntR; COG1802
1400867006857	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1400867006858	DNA-binding site [nucleotide binding]; DNA binding site
1400867006859	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
1400867006860	MarR family; Region: MarR_2; pfam12802
1400867006861	putative 3-hydroxyphenylpropionic transporter MhpT; Provisional; Region: PRK11551
1400867006862	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1400867006863	putative substrate translocation pore; other site
1400867006864	p-hydroxycinnamoyl CoA hydratase/lyase; Validated; Region: PRK09120
1400867006865	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
1400867006866	substrate binding site [chemical binding]; other site
1400867006867	oxyanion hole (OAH) forming residues; other site
1400867006868	trimer interface [polypeptide binding]; other site
1400867006869	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
1400867006870	Salicylaldehyde dehydrogenase, DoxF-like; Region: ALDH_SaliADH; cd07105
1400867006871	NAD(P) binding site [chemical binding]; other site
1400867006872	catalytic residues [active]
1400867006873	feruloyl-CoA synthase; Reviewed; Region: PRK08180
1400867006874	Feruloyl-CoA synthetase (FCS); Region: FCS; cd05921
1400867006875	acyl-activating enzyme (AAE) consensus motif; other site
1400867006876	putative AMP binding site [chemical binding]; other site
1400867006877	putative active site [active]
1400867006878	putative CoA binding site [chemical binding]; other site
1400867006879	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
1400867006880	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
1400867006881	active site
1400867006882	outer membrane porin, OprD family; Region: OprD; pfam03573
1400867006883	Protein of unknown function (DUF3237); Region: DUF3237; pfam11578
1400867006884	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
1400867006885	Thioesterase-like superfamily; Region: 4HBT_3; pfam13622
1400867006886	CoenzymeA binding site [chemical binding]; other site
1400867006887	subunit interaction site [polypeptide binding]; other site
1400867006888	PHB binding site; other site
1400867006889	Tannase and feruloyl esterase; Region: Tannase; pfam07519
1400867006890	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
1400867006891	Transcriptional regulators [Transcription]; Region: FadR; COG2186
1400867006892	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1400867006893	DNA-binding site [nucleotide binding]; DNA binding site
1400867006894	FCD domain; Region: FCD; pfam07729
1400867006895	NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012
1400867006896	Alpha-Ketoglutaric Semialdehyde Dehydrogenase; Region: ALDH_KGSADH; cd07129
1400867006897	dimer interface [polypeptide binding]; other site
1400867006898	NADP binding site [chemical binding]; other site
1400867006899	catalytic residues [active]
1400867006900	5-dehydro-4-deoxyglucarate dehydratase, also called 5-keto-4-deoxy-glucarate dehydratase (KDGDH); Region: KDGDH; cd00951
1400867006901	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
1400867006902	putative active site [active]
1400867006903	catalytic residue [active]
1400867006904	glucarate dehydratase; Region: glucar-dehydr; TIGR03247
1400867006905	D-Glucarate dehydratase (GlucD) catalyzes the dehydration of both D-glucarate and L-idarate to form 5-keto-4-deoxy-D-glucarate (5-KDG) , the initial reaction of the catabolic pathway for (D)-glucarate. GlucD belongs to the enolase superfamily of enzymes; Region: D-glucarate_dehydratase; cd03323
1400867006906	active site
1400867006907	tetramer interface [polypeptide binding]; other site
1400867006908	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1400867006909	D-galactonate transporter; Region: 2A0114; TIGR00893
1400867006910	putative substrate translocation pore; other site
1400867006911	Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613
1400867006912	D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; cl17802
1400867006913	D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295
1400867006914	EamA-like transporter family; Region: EamA; pfam00892
1400867006915	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
1400867006916	Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625
1400867006917	aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381
1400867006918	Coniferyl aldehyde dehydrogenase-like; Region: ALDH_CALDH_CalB; cd07133
1400867006919	NAD(P) binding site [chemical binding]; other site
1400867006920	catalytic residues [active]
1400867006921	Possible hemagglutinin (DUF637); Region: DUF637; pfam04830
1400867006922	Pre-toxin domain with VENN motif; Region: PT-VENN; pfam04829
1400867006923	DNA/RNA non-specific endonuclease; Region: Endonuclea_NS_2; pfam13930
1400867006924	haemagglutination activity domain; Region: Haemagg_act; pfam05860
1400867006925	Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831
1400867006926	POTRA domain, ShlB-type; Region: POTRA_2; pfam08479
1400867006927	Haemolysin secretion/activation protein ShlB/FhaC/HecB; Region: ShlB; pfam03865
1400867006928	D-alanine/D-serine/glycine permease; Provisional; Region: PRK11049
1400867006929	Arginine/ornithine N-succinyltransferase beta subunit [Amino acid transport and metabolism]; Region: AstA; COG3138
1400867006930	Arginine N-succinyltransferase beta subunit; Region: AstA; cl11440
1400867006931	bifunctional succinylornithine transaminase/acetylornithine transaminase; Provisional; Region: PRK12381
1400867006932	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
1400867006933	inhibitor-cofactor binding pocket; inhibition site
1400867006934	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1400867006935	catalytic residue [active]
1400867006936	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
1400867006937	AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404
1400867006938	AsnC family; Region: AsnC_trans_reg; pfam01037
1400867006939	gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK13473
1400867006940	Escherichia coli NAD+-dependent gamma-aminobutyraldehyde dehydrogenase YdcW-like; Region: ALDH_ABALDH-YdcW; cd07092
1400867006941	tetrameric interface [polypeptide binding]; other site
1400867006942	NAD binding site [chemical binding]; other site
1400867006943	catalytic residues [active]
1400867006944	substrate binding site [chemical binding]; other site
1400867006945	SnoaL-like domain; Region: SnoaL_2; pfam12680
1400867006946	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
1400867006947	Transcriptional regulators [Transcription]; Region: FadR; COG2186
1400867006948	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1400867006949	DNA-binding site [nucleotide binding]; DNA binding site
1400867006950	FCD domain; Region: FCD; pfam07729
1400867006951	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
1400867006952	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
1400867006953	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
1400867006954	Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113
1400867006955	Putative bacterial lipoprotein (DUF799); Region: DUF799; cl01813
1400867006956	Bor protein; Region: Lambda_Bor; pfam06291
1400867006957	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4259
1400867006958	Curli production assembly/transport component CsgG; Region: CsgG; pfam03783
1400867006959	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1400867006960	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1400867006961	ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464
1400867006962	NLPA lipoprotein; Region: Lipoprotein_9; pfam03180
1400867006963	Bacterial protein of unknown function (DUF898); Region: DUF898; pfam05987
1400867006964	Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501
1400867006965	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
1400867006966	2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli  is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930
1400867006967	active site
1400867006968	FMN binding site [chemical binding]; other site
1400867006969	2,4-decadienoyl-CoA binding site; other site
1400867006970	catalytic residue [active]
1400867006971	4Fe-4S cluster binding site [ion binding]; other site
1400867006972	Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446
1400867006973	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1400867006974	argininosuccinate synthase; Provisional; Region: PRK13820
1400867006975	Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate .  In...; Region: Argininosuccinate_Synthase; cd01999
1400867006976	ANP binding site [chemical binding]; other site
1400867006977	Substrate Binding Site II [chemical binding]; other site
1400867006978	Substrate Binding Site I [chemical binding]; other site
1400867006979	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1400867006980	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1400867006981	metal binding site [ion binding]; metal-binding site
1400867006982	active site
1400867006983	I-site; other site
1400867006984	Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294
1400867006985	active site
1400867006986	substrate binding pocket [chemical binding]; other site
1400867006987	dimer interface [polypeptide binding]; other site
1400867006988	DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847
1400867006989	DEDDh 3'-5' exonuclease domain of RNase T; Region: RNaseT; cd06134
1400867006990	dimer interface [polypeptide binding]; other site
1400867006991	catalytic site [active]
1400867006992	putative active site [active]
1400867006993	putative substrate binding site [chemical binding]; other site
1400867006994	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
1400867006995	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
1400867006996	N-terminal plug; other site
1400867006997	ligand-binding site [chemical binding]; other site
1400867006998	Old yellow enzyme (OYE)-related FMN binding domain, group 2.  Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_2_FMN; cd04733
1400867006999	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
1400867007000	putative active site [active]
1400867007001	putative FMN binding site [chemical binding]; other site
1400867007002	putative substrate binding site [chemical binding]; other site
1400867007003	putative catalytic residue [active]
1400867007004	ABC-type uncharacterized transport system, duplicated ATPase component [General function prediction only]; Region: COG4172
1400867007005	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1400867007006	Walker A/P-loop; other site
1400867007007	ATP binding site [chemical binding]; other site
1400867007008	Q-loop/lid; other site
1400867007009	ABC transporter signature motif; other site
1400867007010	Walker B; other site
1400867007011	D-loop; other site
1400867007012	H-loop/switch region; other site
1400867007013	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1400867007014	Walker A/P-loop; other site
1400867007015	ATP binding site [chemical binding]; other site
1400867007016	Q-loop/lid; other site
1400867007017	ABC transporter signature motif; other site
1400867007018	Walker B; other site
1400867007019	D-loop; other site
1400867007020	H-loop/switch region; other site
1400867007021	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4239
1400867007022	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1400867007023	dimer interface [polypeptide binding]; other site
1400867007024	conserved gate region; other site
1400867007025	putative PBP binding loops; other site
1400867007026	ABC-ATPase subunit interface; other site
1400867007027	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4174
1400867007028	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1400867007029	dimer interface [polypeptide binding]; other site
1400867007030	conserved gate region; other site
1400867007031	ABC-ATPase subunit interface; other site
1400867007032	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
1400867007033	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497
1400867007034	membrane-bound lytic murein transglycosylase D; Provisional; Region: mltD; PRK10783
1400867007035	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
1400867007036	N-acetyl-D-glucosamine binding site [chemical binding]; other site
1400867007037	catalytic residue [active]
1400867007038	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1400867007039	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1400867007040	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1400867007041	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
1400867007042	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1400867007043	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1400867007044	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
1400867007045	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1400867007046	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
1400867007047	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1400867007048	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1400867007049	RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278
1400867007050	RNA/DNA hybrid binding site [nucleotide binding]; other site
1400867007051	active site
1400867007052	DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406
1400867007053	DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131
1400867007054	active site
1400867007055	catalytic site [active]
1400867007056	substrate binding site [chemical binding]; other site
1400867007057	NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296
1400867007058	NADH pyrophosphatase; Reviewed; Region: nudC; PRK00241
1400867007059	NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297
1400867007060	NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429
1400867007061	putative NADH binding site [chemical binding]; other site
1400867007062	putative active site [active]
1400867007063	nudix motif; other site
1400867007064	putative metal binding site [ion binding]; other site
1400867007065	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
1400867007066	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
1400867007067	substrate binding pocket [chemical binding]; other site
1400867007068	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
1400867007069	Predicted periplasmic or secreted lipoprotein [General function prediction only]; Region: OsmY; COG2823
1400867007070	BON domain; Region: BON; pfam04972
1400867007071	hypothetical protein; Provisional; Region: PRK14674
1400867007072	Predicted methyltransferases [General function prediction only]; Region: COG0313
1400867007073	Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648
1400867007074	putative SAM binding site [chemical binding]; other site
1400867007075	putative homodimer interface [polypeptide binding]; other site
1400867007076	chromosome replication initiation inhibitor protein; Validated; Region: PRK03635
1400867007077	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1400867007078	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1400867007079	dimerization interface [polypeptide binding]; other site
1400867007080	Lysine efflux permease [General function prediction only]; Region: COG1279
1400867007081	Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230
1400867007082	Cd(II)/Pb(II)-responsive transcriptional regulator; Region: CadR-PbrR; TIGR02047
1400867007083	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
1400867007084	DNA binding residues [nucleotide binding]
1400867007085	Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988
1400867007086	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
1400867007087	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
1400867007088	Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988
1400867007089	Aminopeptidase P, N-terminal domain; Region: AMP_N; pfam05195
1400867007090	proline aminopeptidase P II; Provisional; Region: PRK10879
1400867007091	Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087
1400867007092	active site
1400867007093	Uncharacterized protein family (UPF0149); Region: UPF0149; pfam03695
1400867007094	Cell division protein ZapA; Region: ZapA; pfam05164
1400867007095	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
1400867007096	active site
1400867007097	Int/Topo IB signature motif; other site
1400867007098	DNA binding site [nucleotide binding]
1400867007099	Bacterial SH3 domain; Region: SH3_3; pfam08239
1400867007100	Sulfatase; Region: Sulfatase; pfam00884
1400867007101	Domain of unknown function (DUF1705); Region: DUF1705; pfam08019
1400867007102	Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4705
1400867007103	Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988
1400867007104	Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988
1400867007105	Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988
1400867007106	Uncharacterized ACR, COG2135; Region: DUF159; pfam02586
1400867007107	Bacteriophage abortive infection AbiH; Region: AbiH; pfam14253
1400867007108	Bacteriophage abortive infection AbiH; Region: AbiH; pfam14253
1400867007109	SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974
1400867007110	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
1400867007111	Catalytic site [active]
1400867007112	DNA polymerase V subunit UmuC; Reviewed; Region: umuC; PRK03609
1400867007113	umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700
1400867007114	active site
1400867007115	DNA binding site [nucleotide binding]
1400867007116	Domain of unknown function (DUF4113); Region: DUF4113; pfam13438
1400867007117	Glycosyl hydrolase 108; Region: Glyco_hydro_108; pfam05838
1400867007118	Predicted Peptidoglycan domain; Region: PG_binding_3; pfam09374
1400867007119	Domain of unknown function (DUF1833); Region: DUF1833; pfam08875
1400867007120	tape measure domain; Region: tape_meas_nterm; TIGR02675
1400867007121	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
1400867007122	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
1400867007123	N-acetyl-D-glucosamine binding site [chemical binding]; other site
1400867007124	catalytic residue [active]
1400867007125	Bacterial SH3 domain homologues; Region: SH3b; smart00287
1400867007126	LEM-like domain of lamina-associated polypeptide 2 (LAP2) and similar proteins; Region: LEM_like; cd12935
1400867007127	phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554
1400867007128	Phage protein (N4 Gp49/phage Sf6 gene 66) family; Region: Phage_gp49_66; pfam13876
1400867007129	Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452
1400867007130	Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072
1400867007131	Domain of unknown function (DUF4055); Region: DUF4055; pfam13264
1400867007132	Terminase-like family; Region: Terminase_6; pfam03237
1400867007133	Phage terminase large subunit; Region: Terminase_3; cl12054
1400867007134	Uncharacterized conserved protein (DUF2280); Region: DUF2280; pfam10045
1400867007135	Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277
1400867007136	putative active site [active]
1400867007137	Protein of unknown function (DUF1376); Region: DUF1376; pfam07120
1400867007138	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1400867007139	non-specific DNA binding site [nucleotide binding]; other site
1400867007140	salt bridge; other site
1400867007141	sequence-specific DNA binding site [nucleotide binding]; other site
1400867007142	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1400867007143	non-specific DNA binding site [nucleotide binding]; other site
1400867007144	SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974
1400867007145	salt bridge; other site
1400867007146	sequence-specific DNA binding site [nucleotide binding]; other site
1400867007147	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
1400867007148	Catalytic site [active]
1400867007149	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
1400867007150	flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK12696
1400867007151	serine hydroxymethyltransferase; Reviewed; Region: PRK13034
1400867007152	5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812
1400867007153	5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727
1400867007154	SmpA / OmlA family; Region: SmpA_OmlA; pfam04355
1400867007155	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
1400867007156	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
1400867007157	ligand binding site [chemical binding]; other site
1400867007158	Extended Signal Peptide of Type V secretion system; Region: ESPR; pfam13018
1400867007159	YadA-like, left-handed beta-roll; Region: LbR_YadA-like; cd12820
1400867007160	trimer interface [polypeptide binding]; other site
1400867007161	YadA-like, left-handed beta-roll; Region: LbR_YadA-like; cd12820
1400867007162	trimer interface [polypeptide binding]; other site
1400867007163	Left-handed beta-roll, including virulence factors and various other proteins; Region: LbR-like; cl17507
1400867007164	trimer interface [polypeptide binding]; other site
1400867007165	YadA-like, left-handed beta-roll; Region: LbR_YadA-like; cd12820
1400867007166	trimer interface [polypeptide binding]; other site
1400867007167	YadA-like, left-handed beta-roll; Region: LbR_YadA-like; cd12820
1400867007168	trimer interface [polypeptide binding]; other site
1400867007169	Haemagglutinin; Region: HIM; pfam05662
1400867007170	YadA-like C-terminal region; Region: YadA; pfam03895
1400867007171	ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466
1400867007172	Found in ATP-dependent protease La (LON); Region: LON; smart00464
1400867007173	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1400867007174	Walker A motif; other site
1400867007175	ATP binding site [chemical binding]; other site
1400867007176	Walker B motif; other site
1400867007177	arginine finger; other site
1400867007178	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
1400867007179	rRNA large subunit methyltransferase; Provisional; Region: PRK00103
1400867007180	The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363
1400867007181	Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900
1400867007182	putative active site [active]
1400867007183	metal binding site [ion binding]; metal-binding site
1400867007184	META domain; Region: META; pfam03724
1400867007185	META domain; Region: META; pfam03724
1400867007186	Domain of unknown function (DUF4377); Region: DUF4377; pfam14302
1400867007187	NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226
1400867007188	glutamate dehydrogenase; Provisional; Region: PRK09414
1400867007189	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
1400867007190	NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226
1400867007191	NAD(P) binding pocket [chemical binding]; other site
1400867007192	ferredoxin; Provisional; Region: PRK08764
1400867007193	Putative Fe-S cluster; Region: FeS; cl17515
1400867007194	4Fe-4S binding domain; Region: Fer4; pfam00037
1400867007195	Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177
1400867007196	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
1400867007197	minor groove reading motif; other site
1400867007198	helix-hairpin-helix signature motif; other site
1400867007199	substrate binding pocket [chemical binding]; other site
1400867007200	active site
1400867007201	Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576
1400867007202	adenylate kinase; Reviewed; Region: adk; PRK00279
1400867007203	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
1400867007204	AMP-binding site [chemical binding]; other site
1400867007205	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
1400867007206	penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423
1400867007207	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
1400867007208	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
1400867007209	N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742
1400867007210	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1400867007211	S-adenosylmethionine binding site [chemical binding]; other site
1400867007212	HupE / UreJ protein; Region: HupE_UreJ; pfam04955
1400867007213	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
1400867007214	Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830
1400867007215	UreF; Region: UreF; pfam01730
1400867007216	urease accessory protein UreE; Provisional; Region: ureE; PRK13261
1400867007217	UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571
1400867007218	dimer interface [polypeptide binding]; other site
1400867007219	catalytic residues [active]
1400867007220	urease subunit alpha; Reviewed; Region: ureC; PRK13207
1400867007221	Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375
1400867007222	subunit interactions [polypeptide binding]; other site
1400867007223	active site
1400867007224	flap region; other site
1400867007225	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
1400867007226	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
1400867007227	Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407
1400867007228	gamma-beta subunit interface [polypeptide binding]; other site
1400867007229	alpha-beta subunit interface [polypeptide binding]; other site
1400867007230	Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390
1400867007231	alpha-gamma subunit interface [polypeptide binding]; other site
1400867007232	beta-gamma subunit interface [polypeptide binding]; other site
1400867007233	UreD urease accessory protein; Region: UreD; pfam01774
1400867007234	Uncharacterized lipoprotein NlpE involved in copper resistance [Cell envelope biogenesis, outer membrane / Inorganic ion transport and metabolism]; Region: CutF; COG3015
1400867007235	NlpE N-terminal domain; Region: NlpE; pfam04170
1400867007236	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
1400867007237	tetramer interface [polypeptide binding]; other site
1400867007238	active site
1400867007239	Mg2+/Mn2+ binding site [ion binding]; other site
1400867007240	isocitrate lyase; Region: PLN02892
1400867007241	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1400867007242	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1400867007243	The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417
1400867007244	substrate binding pocket [chemical binding]; other site
1400867007245	dimerization interface [polypeptide binding]; other site
1400867007246	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
1400867007247	Domain of unknown function DUF21; Region: DUF21; pfam01595
1400867007248	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
1400867007249	Transporter associated domain; Region: CorC_HlyC; smart01091
1400867007250	H+/citrate symporter [Energy production and conversion]; Region: CitM; COG2851
1400867007251	Citrate transporter; Region: CitMHS; pfam03600
1400867007252	Uncharacterized protein conserved in bacteria (DUF2239); Region: DUF2239; pfam09998
1400867007253	sulfate adenylyltransferase subunit 1; Provisional; Region: cysN; PRK05124
1400867007254	CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166
1400867007255	CysD dimerization site [polypeptide binding]; other site
1400867007256	G1 box; other site
1400867007257	putative GEF interaction site [polypeptide binding]; other site
1400867007258	GTP/Mg2+ binding site [chemical binding]; other site
1400867007259	Switch I region; other site
1400867007260	G2 box; other site
1400867007261	G3 box; other site
1400867007262	Switch II region; other site
1400867007263	G4 box; other site
1400867007264	G5 box; other site
1400867007265	CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695
1400867007266	TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095
1400867007267	sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039
1400867007268	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
1400867007269	Active Sites [active]
1400867007270	Capsule assembly protein Wzi; Region: Caps_assemb_Wzi; pfam14052
1400867007271	lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484
1400867007272	LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322
1400867007273	dimer interface [polypeptide binding]; other site
1400867007274	putative anticodon binding site; other site
1400867007275	Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775
1400867007276	motif 1; other site
1400867007277	active site
1400867007278	motif 2; other site
1400867007279	motif 3; other site
1400867007280	Uncharacterized protein family (UPF0227); Region: UPF0227; cl14886
1400867007281	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
1400867007282	Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814
1400867007283	putative hydrophobic ligand binding site [chemical binding]; other site
1400867007284	Rubredoxin [Energy production and conversion]; Region: COG1773
1400867007285	Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730
1400867007286	iron binding site [ion binding]; other site
1400867007287	NADH:flavorubredoxin oxidoreductase; Provisional; Region: PRK04965
1400867007288	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1400867007289	3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427
1400867007290	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
1400867007291	DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151
1400867007292	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1400867007293	The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411
1400867007294	dimerization interface [polypeptide binding]; other site
1400867007295	Sporulation related domain; Region: SPOR; cl10051
1400867007296	polyphosphate kinase; Provisional; Region: PRK05443
1400867007297	Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089
1400867007298	Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503
1400867007299	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
1400867007300	putative active site [active]
1400867007301	catalytic site [active]
1400867007302	Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168
1400867007303	putative active site [active]
1400867007304	putative domain interface [polypeptide binding]; other site
1400867007305	catalytic site [active]
1400867007306	monofunctional biosynthetic peptidoglycan transglycosylase; Provisional; Region: mtgA; PRK00056
1400867007307	Transglycosylase; Region: Transgly; cl17702
1400867007308	Rhomboid family; Region: Rhomboid; pfam01694
1400867007309	Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127
1400867007310	FtsX-like permease family; Region: FtsX; pfam02687
1400867007311	FtsX-like permease family; Region: FtsX; pfam02687
1400867007312	Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG4181
1400867007313	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
1400867007314	Walker A/P-loop; other site
1400867007315	ATP binding site [chemical binding]; other site
1400867007316	Q-loop/lid; other site
1400867007317	ABC transporter signature motif; other site
1400867007318	Walker B; other site
1400867007319	D-loop; other site
1400867007320	H-loop/switch region; other site
1400867007321	Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822
1400867007322	active site
1400867007323	catalytic triad [active]
1400867007324	oxyanion hole [active]
1400867007325	switch loop; other site
1400867007326	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378
1400867007327	active site clefts [active]
1400867007328	zinc binding site [ion binding]; other site
1400867007329	dimer interface [polypeptide binding]; other site
1400867007330	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
1400867007331	Lipase.  Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883
1400867007332	nucleophilic elbow; other site
1400867007333	catalytic triad; other site
1400867007334	outer membrane receptor FepA; Provisional; Region: PRK13524
1400867007335	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
1400867007336	N-terminal plug; other site
1400867007337	ligand-binding site [chemical binding]; other site
1400867007338	Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316
1400867007339	IscR-regulated protein YhgI; Region: YhgI_GntY; TIGR03341
1400867007340	Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694
1400867007341	Rhomboid family; Region: Rhomboid; cl11446
1400867007342	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
1400867007343	Sulfatase; Region: Sulfatase; pfam00884
1400867007344	Uncharacterized conserved protein [Function unknown]; Region: COG1262
1400867007345	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
1400867007346	D-Serine dehydratase is a pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of L- or D-serine  to pyruvate and ammonia.  D-serine dehydratase serves as a detoxifying enzyme in most E. coli strains where D-serine is a competitive...; Region: D-Ser-dehyd; cd06447
1400867007347	Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291
1400867007348	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1400867007349	catalytic residue [active]
1400867007350	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
1400867007351	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
1400867007352	B12-dependent methionine synthase; Provisional; Region: metH; PRK09490
1400867007353	Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646
1400867007354	MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH).  Cobalamin-dependent...; Region: MeTr; cd00740
1400867007355	substrate binding pocket [chemical binding]; other site
1400867007356	B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069
1400867007357	B12 binding site [chemical binding]; other site
1400867007358	cobalt ligand [ion binding]; other site
1400867007359	Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965
1400867007360	Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958
1400867007361	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
1400867007362	PYR/PP interface [polypeptide binding]; other site
1400867007363	dimer interface [polypeptide binding]; other site
1400867007364	TPP binding site [chemical binding]; other site
1400867007365	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
1400867007366	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
1400867007367	TPP-binding site [chemical binding]; other site
1400867007368	dimer interface [polypeptide binding]; other site
1400867007369	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1400867007370	D-galactonate transporter; Region: 2A0114; TIGR00893
1400867007371	putative substrate translocation pore; other site
1400867007372	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
1400867007373	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1400867007374	NAD(P) binding site [chemical binding]; other site
1400867007375	active site
1400867007376	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
1400867007377	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1400867007378	The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432
1400867007379	dimerization interface [polypeptide binding]; other site
1400867007380	substrate binding pocket [chemical binding]; other site
1400867007381	galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019
1400867007382	active site
1400867007383	catalytic residues [active]
1400867007384	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1400867007385	putative substrate translocation pore; other site
1400867007386	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1400867007387	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
1400867007388	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1400867007389	glutaminase; Provisional; Region: PRK00971
1400867007390	Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066
1400867007391	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
1400867007392	active site
1400867007393	catalytic residues [active]
1400867007394	metal binding site [ion binding]; metal-binding site
1400867007395	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1400867007396	metabolite-proton symporter; Region: 2A0106; TIGR00883
1400867007397	putative substrate translocation pore; other site
1400867007398	hypothetical protein; Provisional; Region: PRK07064
1400867007399	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
1400867007400	PYR/PP interface [polypeptide binding]; other site
1400867007401	dimer interface [polypeptide binding]; other site
1400867007402	TPP binding site [chemical binding]; other site
1400867007403	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
1400867007404	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568
1400867007405	TPP-binding site [chemical binding]; other site
1400867007406	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
1400867007407	Uncharacterized Candidatus pelagibacter aldehyde dehydrogenase, DhaS-like; Region: ALDH_DhaS; cd07114
1400867007408	NAD(P) binding site [chemical binding]; other site
1400867007409	catalytic residues [active]
1400867007410	L-aspartate dehydrogenase; Provisional; Region: PRK13303
1400867007411	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
1400867007412	Domain of unknown function DUF108; Region: DUF108; pfam01958
1400867007413	short chain dehydrogenase; Provisional; Region: PRK07062
1400867007414	putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344
1400867007415	putative NAD(P) binding site [chemical binding]; other site
1400867007416	putative active site [active]
1400867007417	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
1400867007418	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
1400867007419	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
1400867007420	Cupin domain; Region: Cupin_2; pfam07883
1400867007421	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1400867007422	D-galactonate transporter; Region: 2A0114; TIGR00893
1400867007423	putative substrate translocation pore; other site
1400867007424	phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754
1400867007425	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1400867007426	C-terminal domain of Burkholderia sp. NF100 MhqB and similar proteins; MhqB is a type I extradiol dioxygenase involved in the catabolism of methylhydroquinone, an intermediate in the degradation of fenitrothion; Region: MhqB_like_C; cd08360
1400867007427	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1400867007428	putative active site [active]
1400867007429	putative metal binding site [ion binding]; other site
1400867007430	short chain dehydrogenase; Provisional; Region: PRK12939
1400867007431	classical (c) SDRs; Region: SDR_c; cd05233
1400867007432	NAD(P) binding site [chemical binding]; other site
1400867007433	active site
1400867007434	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
1400867007435	Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469
1400867007436	[2Fe-2S] cluster binding site [ion binding]; other site
1400867007437	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
1400867007438	hydrophobic ligand binding site; other site
1400867007439	Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528
1400867007440	[2Fe-2S] cluster binding site [ion binding]; other site
1400867007441	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
1400867007442	Transcriptional regulator [Transcription]; Region: IclR; COG1414
1400867007443	Bacterial transcriptional regulator; Region: IclR; pfam01614
1400867007444	Nicotinamide mononucleotide transporter; Region: NMN_transporter; pfam04973
1400867007445	enoyl-CoA hydratase; Provisional; Region: PRK06563
1400867007446	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
1400867007447	substrate binding site [chemical binding]; other site
1400867007448	oxyanion hole (OAH) forming residues; other site
1400867007449	trimer interface [polypeptide binding]; other site
1400867007450	PgaD-like protein; Region: PgaD; pfam13994
1400867007451	N-glycosyltransferase; Provisional; Region: PRK11204
1400867007452	CESA_like is  the cellulose synthase superfamily; Region: CESA_like; cd06423
1400867007453	DXD motif; other site
1400867007454	poly-beta-1,6-N-acetyl-D-glucosamine N-deacetylase PgaB; Region: deacetyl_PgaB; TIGR03938
1400867007455	N-terminal putative catalytic polysaccharide deacetylase domain of bacterial poly-beta-1,6-N-acetyl-D-glucosamine N-deacetylase PgaB, and similar proteins; Region: CE4_PgaB_5s; cd10964
1400867007456	putative active site [active]
1400867007457	putative metal binding site [ion binding]; other site
1400867007458	FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545
1400867007459	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
1400867007460	YaeQ protein; Region: YaeQ; pfam07152
1400867007461	C4-dicarboxylate transporter DctA; Reviewed; Region: PRK13027
1400867007462	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
1400867007463	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
1400867007464	CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492
1400867007465	Brown fat-inducible thioesterase (BFIT).  Brain acyl-CoA hydrolase (BACH).  These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442
1400867007466	Multiple antibiotic transporter [Intracellular trafficking and secretion]; Region: MarC; COG2095
1400867007467	choline transport protein BetT; Provisional; Region: PRK09928
1400867007468	BCCT family transporter; Region: BCCT; pfam02028
1400867007469	transcriptional regulator BetI; Validated; Region: PRK00767
1400867007470	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1400867007471	Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977
1400867007472	betaine aldehyde dehydrogenase; Provisional; Region: PRK13252
1400867007473	NAD+-dependent 4-trimethylaminobutyraldehyde dehydrogenase, ALDH family 9A1; Region: ALDH_F9_TMBADH; cd07090
1400867007474	tetrameric interface [polypeptide binding]; other site
1400867007475	NAD binding site [chemical binding]; other site
1400867007476	catalytic residues [active]
1400867007477	choline dehydrogenase; Validated; Region: PRK02106
1400867007478	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
1400867007479	malate:quinone oxidoreductase; Validated; Region: PRK05257
1400867007480	malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320
1400867007481	Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574
1400867007482	Homocysteine/selenocysteine methylase (S-methylmethionine-dependent) [Amino acid transport and metabolism]; Region: MHT1; COG2040
1400867007483	arginine-ornithine antiporter; Region: arg_ornith_anti; TIGR03810
1400867007484	PGAP1-like protein; Region: PGAP1; pfam07819
1400867007485	Protein of unknown function (DUF1275); Region: DUF1275; pfam06912
1400867007486	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2832
1400867007487	Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cd00232
1400867007488	heme binding pocket [chemical binding]; other site
1400867007489	heme ligand [chemical binding]; other site
1400867007490	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
1400867007491	TPR repeat; Region: TPR_11; pfam13414
1400867007492	Protein of unknown function (DUF560); Region: DUF560; pfam04575
1400867007493	Secretin and TonB N terminus short domain; Region: STN; pfam07660
1400867007494	TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786
1400867007495	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
1400867007496	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
1400867007497	Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712
1400867007498	FecR protein; Region: FecR; pfam04773
1400867007499	RNA polymerase sigma factor; Reviewed; Region: PRK12523
1400867007500	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1400867007501	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1400867007502	DNA binding residues [nucleotide binding]
1400867007503	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1400867007504	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1400867007505	The C-teminal substrate binding domain of LysR-like nitrogen assimilation control (NAC) protein, contains the type 2 periplasmic binding fold; Region: PBP2_Nac; cd08433
1400867007506	putative dimerization interface [polypeptide binding]; other site
1400867007507	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
1400867007508	Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408
1400867007509	inhibitor site; inhibition site
1400867007510	active site
1400867007511	dimer interface [polypeptide binding]; other site
1400867007512	catalytic residue [active]
1400867007513	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1400867007514	benzoate transport; Region: 2A0115; TIGR00895
1400867007515	putative substrate translocation pore; other site
1400867007516	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1400867007517	outer membrane porin, OprD family; Region: OprD; pfam03573
1400867007518	GIY-YIG domain of uncharacterized hypothetical protein found in bacteria and archaea; Region: GIY-YIG_unchar_2; cd10447
1400867007519	GIY-YIG motif/motif A; other site
1400867007520	putative active site [active]
1400867007521	putative metal binding site [ion binding]; other site
1400867007522	Domain of unknown function (DUF4357); Region: DUF4357; pfam14267
1400867007523	EcoKI restriction-modification system protein HsdS; Provisional; Region: PRK09737
1400867007524	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
1400867007525	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
1400867007526	HsdM N-terminal domain; Region: HsdM_N; pfam12161
1400867007527	N-6 DNA Methylase; Region: N6_Mtase; pfam02384
1400867007528	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1400867007529	S-adenosylmethionine binding site [chemical binding]; other site
1400867007530	type I restriction enzyme EcoKI subunit R; Provisional; Region: hsdR; PRK11448
1400867007531	Domain of unknown function (DUF4145); Region: DUF4145; pfam13643
1400867007532	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313
1400867007533	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1400867007534	ATP binding site [chemical binding]; other site
1400867007535	putative Mg++ binding site [ion binding]; other site
1400867007536	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1400867007537	nucleotide binding region [chemical binding]; other site
1400867007538	ATP-binding site [chemical binding]; other site
1400867007539	Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405
1400867007540	Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019
1400867007541	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1400867007542	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1400867007543	putative substrate translocation pore; other site
1400867007544	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1400867007545	efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998
1400867007546	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
1400867007547	HlyD family secretion protein; Region: HlyD_3; pfam13437
1400867007548	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
1400867007549	CoenzymeA binding site [chemical binding]; other site
1400867007550	subunit interaction site [polypeptide binding]; other site
1400867007551	PHB binding site; other site
1400867007552	Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823
1400867007553	dimer interface [polypeptide binding]; other site
1400867007554	allosteric magnesium binding site [ion binding]; other site
1400867007555	active site
1400867007556	aspartate-rich active site metal binding site; other site
1400867007557	Schiff base residues; other site
1400867007558	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
1400867007559	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1400867007560	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
1400867007561	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1400867007562	Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090
1400867007563	NAD(P) binding site [chemical binding]; other site
1400867007564	active site
1400867007565	N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247
1400867007566	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1400867007567	OsmC-like protein; Region: OsmC; cl00767
1400867007568	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
1400867007569	Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840
1400867007570	active site
1400867007571	metal binding site [ion binding]; metal-binding site
1400867007572	DNA binding site [nucleotide binding]
1400867007573	Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320
1400867007574	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1400867007575	Walker A/P-loop; other site
1400867007576	ATP binding site [chemical binding]; other site
1400867007577	Q-loop/lid; other site
1400867007578	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1400867007579	ABC transporter signature motif; other site
1400867007580	Walker B; other site
1400867007581	D-loop; other site
1400867007582	H-loop/switch region; other site
1400867007583	Pyridoxal 5-phosphate (PLP)-binding TIM barrel domain of Type III PLP-Dependent Enzymes, Yggs-like proteins; Region: PLPDE_III_Yggs_like; cd06824
1400867007584	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
1400867007585	catalytic residue [active]
1400867007586	Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805
1400867007587	Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131
1400867007588	Walker A motif; other site
1400867007589	ATP binding site [chemical binding]; other site
1400867007590	Walker B motif; other site
1400867007591	Tfp pilus assembly protein, ATPase PilU [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilU; COG5008
1400867007592	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
1400867007593	Walker A motif; other site
1400867007594	ATP binding site [chemical binding]; other site
1400867007595	Walker B motif; other site
1400867007596	ferric uptake regulator; Provisional; Region: fur; PRK09462
1400867007597	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
1400867007598	metal binding site 2 [ion binding]; metal-binding site
1400867007599	putative DNA binding helix; other site
1400867007600	metal binding site 1 [ion binding]; metal-binding site
1400867007601	dimer interface [polypeptide binding]; other site
1400867007602	structural Zn2+ binding site [ion binding]; other site
1400867007603	outer membrane biogenesis protein BamE; Provisional; Region: PRK11548
1400867007604	SmpA / OmlA family; Region: SmpA_OmlA; pfam04355
1400867007605	hypothetical protein; Validated; Region: PRK01777
1400867007606	Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456
1400867007607	Hemerythrin; Region: Hemerythrin; cd12107
1400867007608	Fe binding site [ion binding]; other site
1400867007609	Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121
1400867007610	Glutamine amidotransferases class-II (Gn-AT)_YafJ-type.  YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea.  YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908
1400867007611	putative active site [active]
1400867007612	putative dimer interface [polypeptide binding]; other site
1400867007613	Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; pfam13444
1400867007614	AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250
1400867007615	feedback inhibition sensing region; other site
1400867007616	homohexameric interface [polypeptide binding]; other site
1400867007617	nucleotide binding site [chemical binding]; other site
1400867007618	N-acetyl-L-glutamate binding site [chemical binding]; other site
1400867007619	Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109
1400867007620	The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089
1400867007621	active site
1400867007622	substrate binding site [chemical binding]; other site
1400867007623	metal binding site [ion binding]; metal-binding site
1400867007624	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
1400867007625	trimer interface [polypeptide binding]; other site
1400867007626	active site
1400867007627	ATP-dependent DNA helicase Rep; Region: rep; TIGR01074
1400867007628	Part of AAA domain; Region: AAA_19; pfam13245
1400867007629	Family description; Region: UvrD_C_2; pfam13538
1400867007630	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
1400867007631	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
1400867007632	ligand binding site [chemical binding]; other site
1400867007633	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
1400867007634	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; Region: LPLAT_LCLAT1-like; cd07990
1400867007635	putative acyl-acceptor binding pocket; other site
1400867007636	Septum formation inhibitor [Cell division and chromosome partitioning]; Region: MinC; COG0850
1400867007637	Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775
1400867007638	Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894
1400867007639	Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036
1400867007640	Switch I; other site
1400867007641	Switch II; other site
1400867007642	Septum formation topological specificity factor MinE; Region: MinE; pfam03776
1400867007643	Domain of unknown function (DUF4234); Region: DUF4234; pfam14018
1400867007644	threonine efflux system; Provisional; Region: PRK10229
1400867007645	Domain of unknown function (DUF4117); Region: DUF4117; pfam13491
1400867007646	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
1400867007647	This domain directs oriented DNA translocation and forms a winged helix structure; Region: Ftsk_gamma; smart00843
1400867007648	thioredoxin reductase; Provisional; Region: PRK10262
1400867007649	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1400867007650	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1400867007651	leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301
1400867007652	arginyl-tRNA-protein transferase; Provisional; Region: PRK01305
1400867007653	Arginine-tRNA-protein transferase, N terminus; Region: ATE_N; pfam04376
1400867007654	Arginine-tRNA-protein transferase, C terminus; Region: ATE_C; pfam04377
1400867007655	ribosomal-protein-alanine N-acetyltransferase; Provisional; Region: rimI; PRK09491
1400867007656	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1400867007657	Coenzyme A binding pocket [chemical binding]; other site
1400867007658	Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687
1400867007659	Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118
1400867007660	Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687
1400867007661	Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118
1400867007662	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
1400867007663	G5 box; other site
1400867007664	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
1400867007665	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
1400867007666	Antibiotic Binding Site [chemical binding]; other site
1400867007667	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
1400867007668	G1 box; other site
1400867007669	GTP/Mg2+ binding site [chemical binding]; other site
1400867007670	G2 box; other site
1400867007671	Switch I region; other site
1400867007672	G3 box; other site
1400867007673	Switch II region; other site
1400867007674	G4 box; other site
1400867007675	elongation factor G; Reviewed; Region: PRK00007
1400867007676	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
1400867007677	G1 box; other site
1400867007678	putative GEF interaction site [polypeptide binding]; other site
1400867007679	GTP/Mg2+ binding site [chemical binding]; other site
1400867007680	Switch I region; other site
1400867007681	G2 box; other site
1400867007682	G3 box; other site
1400867007683	Switch II region; other site
1400867007684	G4 box; other site
1400867007685	G5 box; other site
1400867007686	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
1400867007687	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
1400867007688	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
1400867007689	30S ribosomal protein S7; Validated; Region: PRK05302
1400867007690	S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368
1400867007691	S17 interaction site [polypeptide binding]; other site
1400867007692	S8 interaction site; other site
1400867007693	16S rRNA interaction site [nucleotide binding]; other site
1400867007694	streptomycin interaction site [chemical binding]; other site
1400867007695	23S rRNA interaction site [nucleotide binding]; other site
1400867007696	aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site
1400867007697	EcsC protein family; Region: EcsC; pfam12787
1400867007698	3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK07967
1400867007699	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
1400867007700	dimer interface [polypeptide binding]; other site
1400867007701	active site
1400867007702	Uncharacterized protein family (UPF0093); Region: UPF0093; pfam03653
1400867007703	Pirin; Region: Pirin; pfam02678
1400867007704	Pirin-related protein [General function prediction only]; Region: COG1741
1400867007705	Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726
1400867007706	NAD synthetase; Provisional; Region: PRK13981
1400867007707	Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570
1400867007708	multimer interface [polypeptide binding]; other site
1400867007709	active site
1400867007710	catalytic triad [active]
1400867007711	protein interface 1 [polypeptide binding]; other site
1400867007712	NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553
1400867007713	homodimer interface [polypeptide binding]; other site
1400867007714	NAD binding pocket [chemical binding]; other site
1400867007715	ATP binding pocket [chemical binding]; other site
1400867007716	Mg binding site [ion binding]; other site
1400867007717	active-site loop [active]
1400867007718	phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168
1400867007719	Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163
1400867007720	active site
1400867007721	Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294
1400867007722	SmpB-tmRNA interface; other site
1400867007723	Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655
1400867007724	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
1400867007725	Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578
1400867007726	Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496
1400867007727	23S rRNA pseudouridine synthase D; Provisional; Region: rluD; PRK11180
1400867007728	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1400867007729	RNA binding surface [nucleotide binding]; other site
1400867007730	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
1400867007731	active site
1400867007732	Outer membrane lipoprotein; Region: YfiO; pfam13525
1400867007733	DNA primase; Validated; Region: dnaG; PRK05667
1400867007734	CHC2 zinc finger; Region: zf-CHC2; pfam01807
1400867007735	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
1400867007736	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
1400867007737	active site
1400867007738	metal binding site [ion binding]; metal-binding site
1400867007739	interdomain interaction site; other site
1400867007740	DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410
1400867007741	glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045
1400867007742	NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213
1400867007743	tRNA; other site
1400867007744	putative tRNA binding site [nucleotide binding]; other site
1400867007745	putative NADP binding site [chemical binding]; other site
1400867007746	Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745
1400867007747	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1400867007748	binding surface
1400867007749	TPR motif; other site
1400867007750	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1400867007751	binding surface
1400867007752	TPR motif; other site
1400867007753	outer membrane lipoprotein LolB; Provisional; Region: lolB; PRK00022
1400867007754	Outer membrane lipoprotein LolB; Region: LolB; pfam03550
1400867007755	4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00343
1400867007756	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
1400867007757	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
1400867007758	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259
1400867007759	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
1400867007760	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1400867007761	active site
1400867007762	Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495
1400867007763	5S rRNA interface [nucleotide binding]; other site
1400867007764	CTC domain interface [polypeptide binding]; other site
1400867007765	L16 interface [polypeptide binding]; other site
1400867007766	Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
1400867007767	putative active site [active]
1400867007768	catalytic residue [active]
1400867007769	Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent  decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919
1400867007770	tetramerization interface [polypeptide binding]; other site
1400867007771	active site
1400867007772	GDYXXLXY protein; Region: GDYXXLXY; pfam14345
1400867007773	Predicted membrane protein (DUF2157); Region: DUF2157; cl10480
1400867007774	Domain of unknown function (DUF4401); Region: DUF4401; pfam14351
1400867007775	3,4-dihydroxy-2-butanone 4-phosphate synthase; Provisional; Region: ribB; PRK03353
1400867007776	3,4-dihydroxy-2-butanone 4-phosphate synthase [Coenzyme metabolism]; Region: RibB; COG0108
1400867007777	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
1400867007778	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1400867007779	motif II; other site
1400867007780	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
1400867007781	dimer interface [polypeptide binding]; other site
1400867007782	substrate binding site [chemical binding]; other site
1400867007783	ATP binding site [chemical binding]; other site
1400867007784	LysM domain/BON superfamily protein; Provisional; Region: PRK11198
1400867007785	BON domain; Region: BON; pfam04972
1400867007786	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1400867007787	acyl carrier protein; Provisional; Region: acpP; PRK00982
1400867007788	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
1400867007789	3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830
1400867007790	NAD(P) binding site [chemical binding]; other site
1400867007791	homotetramer interface [polypeptide binding]; other site
1400867007792	homodimer interface [polypeptide binding]; other site
1400867007793	active site
1400867007794	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
1400867007795	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
1400867007796	50S ribosomal protein L32; Validated; Region: rpmF; PRK01110
1400867007797	Uncharacterized ACR, COG1399; Region: DUF177; pfam02620
1400867007798	Protein of unknown function, DUF462; Region: DUF462; pfam04315
1400867007799	Telomere recombination; Region: Sua5_yciO_yrdC; cl00305
1400867007800	ScpA/B protein; Region: ScpA_ScpB; cl00598
1400867007801	Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079
1400867007802	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
1400867007803	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1400867007804	RNA binding surface [nucleotide binding]; other site
1400867007805	Pseudouridine synthase, Escherichia coli RluB like; Region: PseudoU_synth_RluB; cd02556
1400867007806	probable active site [active]
1400867007807	dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090
1400867007808	AAA domain; Region: AAA_26; pfam13500
1400867007809	biotin biosynthesis protein BioC; Region: BioC; TIGR02072
1400867007810	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1400867007811	S-adenosylmethionine binding site [chemical binding]; other site
1400867007812	8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958
1400867007813	pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825
1400867007814	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1400867007815	catalytic residue [active]
1400867007816	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
1400867007817	adenosylmethionine--8-amino-7-oxononanoate transaminase; Validated; Region: PRK07986
1400867007818	inhibitor-cofactor binding pocket; inhibition site
1400867007819	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1400867007820	catalytic residue [active]
1400867007821	pimelyl-[acyl-carrier protein] methyl ester esterase; Region: bioH; TIGR01738
1400867007822	Trehalose-6-phosphatase [Carbohydrate transport and metabolism]; Region: OtsB; COG1877
1400867007823	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1400867007824	active site
1400867007825	motif I; other site
1400867007826	motif II; other site
1400867007827	Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788
1400867007828	alpha,alpha-trehalose-phosphate synthase [UDP-forming]; Region: trehalose_OtsA; TIGR02400
1400867007829	active site
1400867007830	homotetramer interface [polypeptide binding]; other site
1400867007831	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1400867007832	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1400867007833	putative substrate translocation pore; other site
1400867007834	Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193
1400867007835	Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907
1400867007836	heme binding site [chemical binding]; other site
1400867007837	ferroxidase pore; other site
1400867007838	ferroxidase diiron center [ion binding]; other site
1400867007839	NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956
1400867007840	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114
1400867007841	nucleotide binding pocket [chemical binding]; other site
1400867007842	K-X-D-G motif; other site
1400867007843	catalytic site [active]
1400867007844	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
1400867007845	NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119
1400867007846	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027
1400867007847	Dimer interface [polypeptide binding]; other site
1400867007848	BRCT sequence motif; other site
1400867007849	ZipA, C-terminal FtsZ-binding domain; Region: ZipA_C; pfam04354
1400867007850	FtsZ protein binding site [polypeptide binding]; other site
1400867007851	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
1400867007852	AAA domain; Region: AAA_23; pfam13476
1400867007853	Walker A/P-loop; other site
1400867007854	ATP binding site [chemical binding]; other site
1400867007855	Q-loop/lid; other site
1400867007856	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
1400867007857	ABC transporter signature motif; other site
1400867007858	Walker B; other site
1400867007859	D-loop; other site
1400867007860	H-loop/switch region; other site
1400867007861	Transcriptional regulators [Transcription]; Region: GntR; COG1802
1400867007862	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1400867007863	DNA-binding site [nucleotide binding]; DNA binding site
1400867007864	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
1400867007865	Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340
1400867007866	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057
1400867007867	Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237
1400867007868	pantothenate kinase; Reviewed; Region: PRK13322
1400867007869	signal recognition particle protein; Provisional; Region: PRK10867
1400867007870	SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963
1400867007871	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
1400867007872	GTP binding site [chemical binding]; other site
1400867007873	Signal peptide binding domain; Region: SRP_SPB; pfam02978
1400867007874	Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504
1400867007875	tRNA-dihydrouridine synthase C; Provisional; Region: PRK10550
1400867007876	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
1400867007877	FMN binding site [chemical binding]; other site
1400867007878	active site
1400867007879	catalytic residues [active]
1400867007880	substrate binding site [chemical binding]; other site
1400867007881	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
1400867007882	trimer interface [polypeptide binding]; other site
1400867007883	active site
1400867007884	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
1400867007885	Uncharacterized protein conserved in bacteria (DUF2062); Region: DUF2062; pfam09835
1400867007886	Phosphorylase superfamily; Region: PNP_UDP_1; pfam01048
1400867007887	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489
1400867007888	MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037
1400867007889	methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133
1400867007890	catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814
1400867007891	active site
1400867007892	HIGH motif; other site
1400867007893	KMSKS motif; other site
1400867007894	Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957
1400867007895	tRNA binding surface [nucleotide binding]; other site
1400867007896	anticodon binding site; other site
1400867007897	tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins.  This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties.  MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800
1400867007898	dimer interface [polypeptide binding]; other site
1400867007899	putative tRNA-binding site [nucleotide binding]; other site
1400867007900	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
1400867007901	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1400867007902	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1400867007903	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1400867007904	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1400867007905	putative substrate translocation pore; other site
1400867007906	efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998
1400867007907	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
1400867007908	HlyD family secretion protein; Region: HlyD_3; pfam13437
1400867007909	Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342
1400867007910	Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291
1400867007911	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1400867007912	catalytic residue [active]
1400867007913	HI0933-like protein; Region: HI0933_like; pfam03486
1400867007914	Conserved TM helix; Region: TM_helix; pfam05552
1400867007915	Conserved TM helix; Region: TM_helix; pfam05552
1400867007916	Conserved TM helix; Region: TM_helix; pfam05552
1400867007917	Conserved TM helix; Region: TM_helix; pfam05552
1400867007918	ferredoxin-NADP reductase; Provisional; Region: PRK10926
1400867007919	Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195
1400867007920	FAD binding pocket [chemical binding]; other site
1400867007921	FAD binding motif [chemical binding]; other site
1400867007922	phosphate binding motif [ion binding]; other site
1400867007923	beta-alpha-beta structure motif; other site
1400867007924	NAD binding pocket [chemical binding]; other site
1400867007925	putative DNA-binding transcriptional regulator; Provisional; Region: PRK10837
1400867007926	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1400867007927	C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420
1400867007928	putative dimerization interface [polypeptide binding]; other site
1400867007929	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
1400867007930	DNA-binding site [nucleotide binding]; DNA binding site
1400867007931	RNA-binding motif; other site
1400867007932	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1400867007933	active site
1400867007934	NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777
1400867007935	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
1400867007936	NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846
1400867007937	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
1400867007938	NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590
1400867007939	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662
1400867007940	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
1400867007941	NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715
1400867007942	NADH:ubiquinone oxidoreductase subunit 6 (chain J) [Energy production and conversion]; Region: NuoJ; COG0839
1400867007943	NADH dehydrogenase subunit J; Provisional; Region: PRK06433
1400867007944	NADH-quinone oxidoreductase, chain I; Region: NuoI; TIGR01971
1400867007945	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
1400867007946	NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076
1400867007947	Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650
1400867007948	NADH dehydrogenase subunit G; Validated; Region: PRK08166
1400867007949	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
1400867007950	catalytic loop [active]
1400867007951	iron binding site [ion binding]; other site
1400867007952	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588
1400867007953	MopB_NDH-1_NuoG2-N7: The second domain of the NuoG subunit (with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex in the respiratory...; Region: MopB_NDH-1_NuoG2-N7; cd02771
1400867007954	[4Fe-4S] binding site [ion binding]; other site
1400867007955	MopB_CT_NDH-1_NuoG2-N7: C-terminal region of the NuoG-like subunit (of the variant with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex...; Region: MopB_CT_NDH-1_NuoG2-N7; cd02788
1400867007956	NADH dehydrogenase I subunit F; Provisional; Region: PRK11278
1400867007957	SLBB domain; Region: SLBB; pfam10531
1400867007958	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928
1400867007959	NADH dehydrogenase subunit E; Validated; Region: PRK07539
1400867007960	TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064
1400867007961	putative dimer interface [polypeptide binding]; other site
1400867007962	[2Fe-2S] cluster binding site [ion binding]; other site
1400867007963	bifunctional NADH:ubiquinone oxidoreductase subunit C/D; Provisional; Region: PRK11742
1400867007964	NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961
1400867007965	NADH dehydrogenase subunit D; Validated; Region: PRK06075
1400867007966	NADH dehydrogenase subunit B; Validated; Region: PRK06411
1400867007967	NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602
1400867007968	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1400867007969	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1400867007970	metal binding site [ion binding]; metal-binding site
1400867007971	active site
1400867007972	I-site; other site
1400867007973	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1400867007974	dimerization interface [polypeptide binding]; other site
1400867007975	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1400867007976	dimer interface [polypeptide binding]; other site
1400867007977	phosphorylation site [posttranslational modification]
1400867007978	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1400867007979	ATP binding site [chemical binding]; other site
1400867007980	Mg2+ binding site [ion binding]; other site
1400867007981	G-X-G motif; other site
1400867007982	DNA-binding transcriptional regulator RstA; Provisional; Region: PRK10701
1400867007983	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1400867007984	active site
1400867007985	phosphorylation site [posttranslational modification]
1400867007986	intermolecular recognition site; other site
1400867007987	dimerization interface [polypeptide binding]; other site
1400867007988	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1400867007989	DNA binding site [nucleotide binding]
1400867007990	ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07207
1400867007991	ATP cone domain; Region: ATP-cone; pfam03477
1400867007992	Class I ribonucleotide reductase; Region: RNR_I; cd01679
1400867007993	active site
1400867007994	dimer interface [polypeptide binding]; other site
1400867007995	catalytic residues [active]
1400867007996	effector binding site; other site
1400867007997	R2 peptide binding site; other site
1400867007998	Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049
1400867007999	dimer interface [polypeptide binding]; other site
1400867008000	putative radical transfer pathway; other site
1400867008001	diiron center [ion binding]; other site
1400867008002	tyrosyl radical; other site
1400867008003	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1400867008004	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1400867008005	Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237
1400867008006	hypothetical protein; Provisional; Region: PRK08356
1400867008007	Methyltransferase domain; Region: Methyltransf_23; pfam13489
1400867008008	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
1400867008009	DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863
1400867008010	DNA methylase; Region: N6_N4_Mtase; pfam01555
1400867008011	DNA methylase; Region: N6_N4_Mtase; cl17433
1400867008012	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
1400867008013	Zn2+ binding site [ion binding]; other site
1400867008014	Mg2+ binding site [ion binding]; other site
1400867008015	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1400867008016	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1400867008017	Flavin Reductases; Region: FlaRed; cl00801
1400867008018	methionine synthase; Provisional; Region: PRK01207
1400867008019	CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311
1400867008020	substrate binding site [chemical binding]; other site
1400867008021	THF binding site; other site
1400867008022	zinc-binding site [ion binding]; other site
1400867008023	Domain of unknown function (DUF1852); Region: DUF1852; pfam08908
1400867008024	PAAR motif; Region: PAAR_motif; pfam05488
1400867008025	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1400867008026	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1400867008027	The C-teminal substrate binding domain of LysR-like nitrogen assimilation control (NAC) protein, contains the type 2 periplasmic binding fold; Region: PBP2_Nac; cd08433
1400867008028	putative dimerization interface [polypeptide binding]; other site
1400867008029	citrate-proton symporter; Provisional; Region: PRK15075
1400867008030	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1400867008031	putative substrate translocation pore; other site
1400867008032	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
1400867008033	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
1400867008034	nitrogen assimilation transcriptional regulator; Provisional; Region: PRK11233
1400867008035	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1400867008036	The C-teminal substrate binding domain of LysR-like nitrogen assimilation control (NAC) protein, contains the type 2 periplasmic binding fold; Region: PBP2_Nac; cd08433
1400867008037	putative dimerization interface [polypeptide binding]; other site
1400867008038	tricarballylate dehydrogenase; Validated; Region: PRK08274
1400867008039	Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730
1400867008040	tricarballylate utilization protein B; Provisional; Region: PRK15033
1400867008041	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
1400867008042	nitrobindin heme-binding domain; Region: nitrobindin; cl10502
1400867008043	CoA-transferase family III; Region: CoA_transf_3; pfam02515
1400867008044	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1400867008045	putative substrate translocation pore; other site
1400867008046	benzoate transport; Region: 2A0115; TIGR00895
1400867008047	Glutaryl-CoA dehydrogenase; Region: GCD; cd01151
1400867008048	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
1400867008049	FAD binding site [chemical binding]; other site
1400867008050	substrate binding pocket [chemical binding]; other site
1400867008051	catalytic base [active]
1400867008052	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
1400867008053	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1400867008054	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1400867008055	dimerization interface [polypeptide binding]; other site
1400867008056	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
1400867008057	Alcohol dehydrogenases of the MDR family; Region: Zn_ADH8; cd08262
1400867008058	putative NAD(P) binding site [chemical binding]; other site
1400867008059	catalytic Zn binding site [ion binding]; other site
1400867008060	Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816
1400867008061	Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320
1400867008062	active site
1400867008063	purine riboside binding site [chemical binding]; other site
1400867008064	quinolinate synthetase; Provisional; Region: PRK09375
1400867008065	Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152
1400867008066	heterotetramer interface [polypeptide binding]; other site
1400867008067	active site pocket [active]
1400867008068	cleavage site
1400867008069	6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870
1400867008070	methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901
1400867008071	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
1400867008072	DNA binding site [nucleotide binding]
1400867008073	active site
1400867008074	Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076
1400867008075	Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230
1400867008076	Copper resistance protein B precursor (CopB); Region: CopB; pfam05275
1400867008077	copper-resistance protein, CopA family; Region: copper_res_A; TIGR01480
1400867008078	Multicopper oxidase; Region: Cu-oxidase_3; pfam07732
1400867008079	Multicopper oxidase; Region: Cu-oxidase; pfam00394
1400867008080	Multicopper oxidase; Region: Cu-oxidase_2; pfam07731
1400867008081	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1400867008082	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
1400867008083	active site
1400867008084	motif I; other site
1400867008085	motif II; other site
1400867008086	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1400867008087	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
1400867008088	ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163
1400867008089	substrate binding site [chemical binding]; other site
1400867008090	hexamer interface [polypeptide binding]; other site
1400867008091	metal binding site [ion binding]; metal-binding site
1400867008092	Uncharacterized protein conserved in bacteria (DUF2218); Region: DUF2218; pfam09981
1400867008093	S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821
1400867008094	S-formylglutathione hydrolase; Region: PLN02442
1400867008095	Peptidase C13 family; Region: Peptidase_C13; pfam01650
1400867008096	Putative SAM-dependent methyltransferase; Region: SAM_MT; cl17517
1400867008097	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
1400867008098	Glycoprotease family; Region: Peptidase_M22; pfam00814
1400867008099	Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663
1400867008100	Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645
1400867008101	trimer interface [polypeptide binding]; other site
1400867008102	putative metal binding site [ion binding]; other site
1400867008103	Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426
1400867008104	putative active site [active]
1400867008105	putative CoA binding site [chemical binding]; other site
1400867008106	nudix motif; other site
1400867008107	metal binding site [ion binding]; metal-binding site
1400867008108	NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297
1400867008109	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_4; cd04511
1400867008110	nudix motif; other site
1400867008111	Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; cl17479
1400867008112	A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39G; cd02423
1400867008113	putative active site [active]
1400867008114	Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147
1400867008115	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
1400867008116	Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079
1400867008117	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1400867008118	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1400867008119	homodimer interface [polypeptide binding]; other site
1400867008120	catalytic residue [active]
1400867008121	Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572
1400867008122	histidinol dehydrogenase; Region: hisD; TIGR00069
1400867008123	NAD binding site [chemical binding]; other site
1400867008124	dimerization interface [polypeptide binding]; other site
1400867008125	product binding site; other site
1400867008126	substrate binding site [chemical binding]; other site
1400867008127	zinc binding site [ion binding]; other site
1400867008128	catalytic residues [active]
1400867008129	ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040
1400867008130	ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686
1400867008131	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
1400867008132	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
1400867008133	hinge; other site
1400867008134	active site
1400867008135	BolA-like protein; Region: BolA; cl00386
1400867008136	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552
1400867008137	30S subunit binding site; other site
1400867008138	RNA polymerase factor sigma-54; Reviewed; Region: PRK05932
1400867008139	Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309
1400867008140	Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963
1400867008141	Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552
1400867008142	VacJ like lipoprotein; Region: VacJ; cl01073
1400867008143	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
1400867008144	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
1400867008145	anti sigma factor interaction site; other site
1400867008146	regulatory phosphorylation site [posttranslational modification]; other site
1400867008147	Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases); Region: nit; cd07572
1400867008148	nitrilase; Region: PLN02798
1400867008149	putative active site [active]
1400867008150	catalytic triad [active]
1400867008151	dimer interface [polypeptide binding]; other site
1400867008152	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1400867008153	MarR family; Region: MarR; pfam01047
1400867008154	peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561
1400867008155	type II secretion system protein E; Region: type_II_gspE; TIGR02533
1400867008156	PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129
1400867008157	Walker A motif; other site
1400867008158	ATP binding site [chemical binding]; other site
1400867008159	Walker B motif; other site
1400867008160	Protein of unknown function (DUF432); Region: DUF432; cl01027
1400867008161	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
1400867008162	Mechanosensitive ion channel; Region: MS_channel; pfam00924
1400867008163	Predicted membrane protein (DUF2339); Region: DUF2339; pfam10101
1400867008164	DNA polymerase I; Provisional; Region: PRK05755
1400867008165	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
1400867008166	active site
1400867008167	metal binding site 1 [ion binding]; metal-binding site
1400867008168	putative 5' ssDNA interaction site; other site
1400867008169	metal binding site 3; metal-binding site
1400867008170	metal binding site 2 [ion binding]; metal-binding site
1400867008171	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
1400867008172	putative DNA binding site [nucleotide binding]; other site
1400867008173	putative metal binding site [ion binding]; other site
1400867008174	DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139
1400867008175	active site
1400867008176	catalytic site [active]
1400867008177	substrate binding site [chemical binding]; other site
1400867008178	Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637
1400867008179	active site
1400867008180	DNA binding site [nucleotide binding]
1400867008181	catalytic site [active]
1400867008182	YGGT family; Region: YGGT; pfam02325
1400867008183	pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880
1400867008184	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232
1400867008185	tRNA(Ile)-lysidine synthetase; Provisional; Region: tilS; PRK10660
1400867008186	N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992
1400867008187	TilS substrate binding domain; Region: TilS; pfam09179
1400867008188	TilS substrate C-terminal domain; Region: TilS_C; pfam11734
1400867008189	acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724
1400867008190	guanosine pentaphosphate phosphohydrolase; Provisional; Region: PRK11031
1400867008191	Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541
1400867008192	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
1400867008193	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
1400867008194	catalytic residues [active]
1400867008195	transcription termination factor Rho; Provisional; Region: rho; PRK09376
1400867008196	Rho termination factor, N-terminal domain; Region: Rho_N; smart00959
1400867008197	Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459
1400867008198	RNA binding site [nucleotide binding]; other site
1400867008199	Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128
1400867008200	multimer interface [polypeptide binding]; other site
1400867008201	Walker A motif; other site
1400867008202	ATP binding site [chemical binding]; other site
1400867008203	Walker B motif; other site
1400867008204	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
1400867008205	IHF dimer interface [polypeptide binding]; other site
1400867008206	IHF - DNA interface [nucleotide binding]; other site
1400867008207	phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629
1400867008208	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
1400867008209	putative tRNA-binding site [nucleotide binding]; other site
1400867008210	B3/4 domain; Region: B3_4; pfam03483
1400867008211	tRNA synthetase B5 domain; Region: B5; smart00874
1400867008212	Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA,  PheRS is an...; Region: PheRS_beta_core; cd00769
1400867008213	dimer interface [polypeptide binding]; other site
1400867008214	motif 1; other site
1400867008215	motif 3; other site
1400867008216	motif 2; other site
1400867008217	Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147
1400867008218	phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488
1400867008219	Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912
1400867008220	Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496
1400867008221	dimer interface [polypeptide binding]; other site
1400867008222	motif 1; other site
1400867008223	active site
1400867008224	motif 2; other site
1400867008225	motif 3; other site
1400867008226	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
1400867008227	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1400867008228	Coenzyme A binding pocket [chemical binding]; other site
1400867008229	Domain of unknown function (DUF1768); Region: DUF1768; pfam08719
1400867008230	Ribosomal protein L20; Region: Ribosomal_L20; cd07026
1400867008231	23S rRNA binding site [nucleotide binding]; other site
1400867008232	L21 binding site [polypeptide binding]; other site
1400867008233	L13 binding site [polypeptide binding]; other site
1400867008234	50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172
1400867008235	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1400867008236	putative substrate translocation pore; other site
1400867008237	H+ Antiporter protein; Region: 2A0121; TIGR00900
1400867008238	Predicted membrane protein [Function unknown]; Region: COG1238
1400867008239	GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972
1400867008240	GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048
1400867008241	C-terminal domain interface [polypeptide binding]; other site
1400867008242	GSH binding site (G-site) [chemical binding]; other site
1400867008243	dimer interface [polypeptide binding]; other site
1400867008244	C-terminal, alpha helical domain of Escherichia coli YfcG Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YfcG_like; cd10291
1400867008245	N-terminal domain interface [polypeptide binding]; other site
1400867008246	putative dimer interface [polypeptide binding]; other site
1400867008247	active site
1400867008248	Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707
1400867008249	threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413
1400867008250	TGS _ThrRS_N:  ThrRS (threonyl-tRNA Synthetase)  is a class II tRNA synthetase that couples threonine to its cognate tRNA.  In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667
1400867008251	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
1400867008252	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
1400867008253	active site
1400867008254	dimer interface [polypeptide binding]; other site
1400867008255	motif 1; other site
1400867008256	motif 2; other site
1400867008257	motif 3; other site
1400867008258	ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860
1400867008259	anticodon binding site; other site
1400867008260	acyl-CoA synthetase; Validated; Region: PRK08162
1400867008261	Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles and Arabidopsis; Region: ttLC_FACS_AEE21_like; cd12118
1400867008262	acyl-activating enzyme (AAE) consensus motif; other site
1400867008263	putative active site [active]
1400867008264	AMP binding site [chemical binding]; other site
1400867008265	putative CoA binding site [chemical binding]; other site
1400867008266	hypothetical protein; Provisional; Region: PRK05255
1400867008267	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
1400867008268	dimerization domain swap beta strand [polypeptide binding]; other site
1400867008269	regulatory protein interface [polypeptide binding]; other site
1400867008270	active site
1400867008271	regulatory phosphorylation site [posttranslational modification]; other site
1400867008272	glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416
1400867008273	pantoate--beta-alanine ligase; Region: panC; TIGR00018
1400867008274	Pantoate-beta-alanine ligase; Region: PanC; cd00560
1400867008275	active site
1400867008276	ATP-binding site [chemical binding]; other site
1400867008277	pantoate-binding site; other site
1400867008278	HXXH motif; other site
1400867008279	Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557
1400867008280	oligomerization interface [polypeptide binding]; other site
1400867008281	active site
1400867008282	metal binding site [ion binding]; metal-binding site
1400867008283	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483
1400867008284	catalytic center binding site [active]
1400867008285	ATP binding site [chemical binding]; other site
1400867008286	poly(A) polymerase; Region: pcnB; TIGR01942
1400867008287	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
1400867008288	active site
1400867008289	NTP binding site [chemical binding]; other site
1400867008290	metal binding triad [ion binding]; metal-binding site
1400867008291	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
1400867008292	Polymerase A arginine-rich C-terminus; Region: PolyA_pol_arg_C; pfam12626
1400867008293	DNA uptake protein and related DNA-binding proteins [DNA replication, recombination, and repair]; Region: ComEA; COG1555
1400867008294	Helix-hairpin-helix motif; Region: HHH; pfam00633
1400867008295	nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562
1400867008296	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528
1400867008297	homodimer interface [polypeptide binding]; other site
1400867008298	metal binding site [ion binding]; metal-binding site
1400867008299	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529
1400867008300	homodimer interface [polypeptide binding]; other site
1400867008301	active site
1400867008302	putative chemical substrate binding site [chemical binding]; other site
1400867008303	metal binding site [ion binding]; metal-binding site
1400867008304	short chain dehydrogenase; Provisional; Region: PRK08267
1400867008305	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1400867008306	NAD(P) binding site [chemical binding]; other site
1400867008307	active site
1400867008308	HD domain; Region: HD_4; pfam13328
1400867008309	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
1400867008310	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
1400867008311	synthetase active site [active]
1400867008312	NTP binding site [chemical binding]; other site
1400867008313	metal binding site [ion binding]; metal-binding site
1400867008314	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
1400867008315	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
1400867008316	23S rRNA m(5)U1939 methyltransferase; Reviewed; Region: rumA; PRK13168
1400867008317	TRAM domain; Region: TRAM; pfam01938
1400867008318	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
1400867008319	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1400867008320	S-adenosylmethionine binding site [chemical binding]; other site
1400867008321	Uncharacterized bacterial subgroup of the DEDDy 3'-5' exonuclease domain of family-B DNA polymerases; Region: DNA_polB_like1_exo; cd05782
1400867008322	active site
1400867008323	catalytic site [active]
1400867008324	substrate binding site [chemical binding]; other site
1400867008325	Predicted 3'-5' exonuclease related to the exonuclease domain of PolB; Region: DNA_pol_B_exo2; pfam10108
1400867008326	cysteine synthase B; Region: cysM; TIGR01138
1400867008327	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
1400867008328	dimer interface [polypeptide binding]; other site
1400867008329	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1400867008330	catalytic residue [active]
1400867008331	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1400867008332	dimer interface [polypeptide binding]; other site
1400867008333	phosphorylation site [posttranslational modification]
1400867008334	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1400867008335	ATP binding site [chemical binding]; other site
1400867008336	Mg2+ binding site [ion binding]; other site
1400867008337	G-X-G motif; other site
1400867008338	Response regulator receiver domain; Region: Response_reg; pfam00072
1400867008339	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1400867008340	active site
1400867008341	phosphorylation site [posttranslational modification]
1400867008342	intermolecular recognition site; other site
1400867008343	dimerization interface [polypeptide binding]; other site
1400867008344	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086
1400867008345	enoyl-CoA hydratase; Provisional; Region: PRK07509
1400867008346	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
1400867008347	substrate binding site [chemical binding]; other site
1400867008348	oxyanion hole (OAH) forming residues; other site
1400867008349	trimer interface [polypeptide binding]; other site
1400867008350	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
1400867008351	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
1400867008352	hydroxypyruvate isomerase; Region: OH-pyruv-isom; TIGR03234
1400867008353	iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090
1400867008354	retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327
1400867008355	acetoacetyl-CoA reductase; Provisional; Region: PRK12935
1400867008356	putative NAD(P) binding site [chemical binding]; other site
1400867008357	active site
1400867008358	NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233
1400867008359	NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; COG1282
1400867008360	Domain of unknown function (DUF3814); Region: DUF3814; pfam12769
1400867008361	Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304
1400867008362	NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288
1400867008363	ligand binding site [chemical binding]; other site
1400867008364	homodimer interface [polypeptide binding]; other site
1400867008365	NAD(P) binding site [chemical binding]; other site
1400867008366	trimer interface B [polypeptide binding]; other site
1400867008367	trimer interface A [polypeptide binding]; other site
1400867008368	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
1400867008369	EamA-like transporter family; Region: EamA; pfam00892
1400867008370	EamA-like transporter family; Region: EamA; pfam00892
1400867008371	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
1400867008372	homotrimer interaction site [polypeptide binding]; other site
1400867008373	putative active site [active]
1400867008374	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
1400867008375	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1400867008376	putative substrate translocation pore; other site
1400867008377	tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815
1400867008378	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
1400867008379	FMN binding site [chemical binding]; other site
1400867008380	active site
1400867008381	catalytic residues [active]
1400867008382	substrate binding site [chemical binding]; other site
1400867008383	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1400867008384	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1400867008385	The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414
1400867008386	dimerization interface [polypeptide binding]; other site
1400867008387	substrate binding pocket [chemical binding]; other site
1400867008388	Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179
1400867008389	Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755
1400867008390	putative ATP binding site [chemical binding]; other site
1400867008391	putative substrate interface [chemical binding]; other site
1400867008392	aconitate hydratase; Validated; Region: PRK09277
1400867008393	Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285
1400867008394	substrate binding site [chemical binding]; other site
1400867008395	ligand binding site [chemical binding]; other site
1400867008396	Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580
1400867008397	substrate binding site [chemical binding]; other site
1400867008398	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
1400867008399	active site
1400867008400	Domain of unknown function (DUF4163); Region: DUF4163; pfam13739
1400867008401	Protein of unknown function (DUF3298); Region: DUF3298; pfam11738
1400867008402	Protein of unknown function (DUF3298); Region: DUF3298; pfam11738
1400867008403	peptide chain release factor 3; Provisional; Region: prfC; PRK00741
1400867008404	Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169
1400867008405	G1 box; other site
1400867008406	putative GEF interaction site [polypeptide binding]; other site
1400867008407	GTP/Mg2+ binding site [chemical binding]; other site
1400867008408	Switch I region; other site
1400867008409	G2 box; other site
1400867008410	G3 box; other site
1400867008411	Switch II region; other site
1400867008412	G4 box; other site
1400867008413	G5 box; other site
1400867008414	RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689
1400867008415	transcriptional repressor BetI; Region: betaine_BetI; TIGR03384
1400867008416	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1400867008417	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1400867008418	MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300
1400867008419	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1400867008420	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1400867008421	metal binding site [ion binding]; metal-binding site
1400867008422	active site
1400867008423	I-site; other site
1400867008424	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
1400867008425	ketol-acid reductoisomerase; Provisional; Region: PRK05479
1400867008426	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991
1400867008427	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450
1400867008428	acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895
1400867008429	N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878
1400867008430	putative valine binding site [chemical binding]; other site
1400867008431	dimer interface [polypeptide binding]; other site
1400867008432	Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369
1400867008433	acetolactate synthase 3 catalytic subunit; Validated; Region: PRK06466
1400867008434	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
1400867008435	PYR/PP interface [polypeptide binding]; other site
1400867008436	dimer interface [polypeptide binding]; other site
1400867008437	TPP binding site [chemical binding]; other site
1400867008438	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
1400867008439	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
1400867008440	TPP-binding site [chemical binding]; other site
1400867008441	dimer interface [polypeptide binding]; other site
1400867008442	Domain of unknown function (DUF4124); Region: DUF4124; pfam13511
1400867008443	leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390
1400867008444	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
1400867008445	HIGH motif; other site
1400867008446	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
1400867008447	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
1400867008448	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
1400867008449	active site
1400867008450	KMSKS motif; other site
1400867008451	Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958
1400867008452	tRNA binding surface [nucleotide binding]; other site
1400867008453	Lipopolysaccharide-assembly; Region: LptE; pfam04390
1400867008454	DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574
1400867008455	DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144
1400867008456	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
1400867008457	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
1400867008458	HlyD family secretion protein; Region: HlyD_3; pfam13437
1400867008459	macrolide transporter ATP-binding /permease protein; Provisional; Region: PRK10535
1400867008460	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
1400867008461	Walker A/P-loop; other site
1400867008462	ATP binding site [chemical binding]; other site
1400867008463	Q-loop/lid; other site
1400867008464	ABC transporter signature motif; other site
1400867008465	Walker B; other site
1400867008466	D-loop; other site
1400867008467	H-loop/switch region; other site
1400867008468	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
1400867008469	FtsX-like permease family; Region: FtsX; pfam02687
1400867008470	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
1400867008471	Enoyl-[acyl-carrier-protein]; Region: FabI; COG0623
1400867008472	Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372
1400867008473	NAD binding site [chemical binding]; other site
1400867008474	homotetramer interface [polypeptide binding]; other site
1400867008475	homodimer interface [polypeptide binding]; other site
1400867008476	substrate binding site [chemical binding]; other site
1400867008477	active site
1400867008478	Bax inhibitor 1 like; Region: BaxI_1; cl17691
1400867008479	DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135
1400867008480	catalytic site [active]
1400867008481	putative active site [active]
1400867008482	putative substrate binding site [chemical binding]; other site
1400867008483	dimer interface [polypeptide binding]; other site
1400867008484	GTPase RsgA; Reviewed; Region: PRK12288
1400867008485	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
1400867008486	RNA binding site [nucleotide binding]; other site
1400867008487	Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854
1400867008488	GTPase/Zn-binding domain interface [polypeptide binding]; other site
1400867008489	GTP/Mg2+ binding site [chemical binding]; other site
1400867008490	G4 box; other site
1400867008491	G5 box; other site
1400867008492	G1 box; other site
1400867008493	Switch I region; other site
1400867008494	G2 box; other site
1400867008495	G3 box; other site
1400867008496	Switch II region; other site
1400867008497	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
1400867008498	active site residue [active]
1400867008499	Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418
1400867008500	GSH binding site [chemical binding]; other site
1400867008501	catalytic residues [active]
1400867008502	preprotein translocase subunit SecB; Validated; Region: PRK05751
1400867008503	SecA binding site; other site
1400867008504	Preprotein binding site; other site
1400867008505	4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648
1400867008506	GTP-binding protein Der; Reviewed; Region: PRK00093
1400867008507	EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894
1400867008508	G1 box; other site
1400867008509	GTP/Mg2+ binding site [chemical binding]; other site
1400867008510	Switch I region; other site
1400867008511	G2 box; other site
1400867008512	Switch II region; other site
1400867008513	G3 box; other site
1400867008514	G4 box; other site
1400867008515	G5 box; other site
1400867008516	EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895
1400867008517	G1 box; other site
1400867008518	GTP/Mg2+ binding site [chemical binding]; other site
1400867008519	Switch I region; other site
1400867008520	G2 box; other site
1400867008521	G3 box; other site
1400867008522	Switch II region; other site
1400867008523	G4 box; other site
1400867008524	G5 box; other site
1400867008525	outer membrane assembly lipoprotein YfgL; Region: assembly_YfgL; TIGR03300
1400867008526	PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493
1400867008527	Trp docking motif [polypeptide binding]; other site
1400867008528	active site
1400867008529	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2976
1400867008530	Uncharacterized protein conserved in bacteria (DUF2133); Region: DUF2133; pfam09976
1400867008531	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
1400867008532	TPR motif; other site
1400867008533	binding surface
1400867008534	histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037
1400867008535	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
1400867008536	dimer interface [polypeptide binding]; other site
1400867008537	motif 1; other site
1400867008538	active site
1400867008539	motif 2; other site
1400867008540	motif 3; other site
1400867008541	HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859
1400867008542	anticodon binding site; other site
1400867008543	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366
1400867008544	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
1400867008545	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
1400867008546	Helix-turn-helix domain; Region: HTH_25; pfam13413
1400867008547	Domain of unknown function (DUF4115); Region: DUF4115; pfam13464
1400867008548	type IV pilus biogenesis/stability protein PilW; Region: type_IV_pilW; TIGR02521
1400867008549	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
1400867008550	TPR motif; other site
1400867008551	binding surface
1400867008552	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1400867008553	TPR motif; other site
1400867008554	binding surface
1400867008555	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
1400867008556	binding surface
1400867008557	TPR motif; other site
1400867008558	ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK11194
1400867008559	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1400867008560	FeS/SAM binding site; other site
1400867008561	Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413
1400867008562	active site
1400867008563	multimer interface [polypeptide binding]; other site
1400867008564	Iron-sulphur cluster assembly; Region: Fe-S_assembly; pfam04384
1400867008565	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
1400867008566	PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610
1400867008567	active site
1400867008568	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1400867008569	This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814
1400867008570	carboxy-terminal protease; Provisional; Region: PRK11186
1400867008571	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
1400867008572	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
1400867008573	protein binding site [polypeptide binding]; other site
1400867008574	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
1400867008575	Catalytic dyad [active]
1400867008576	C-terminal domain of tail specific protease (DUF3340); Region: DUF3340; pfam11818
1400867008577	beta-hexosaminidase; Provisional; Region: PRK05337
1400867008578	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
1400867008579	Leucine carboxyl methyltransferase; Region: LCM; pfam04072
1400867008580	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
1400867008581	Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079
1400867008582	gamma-glutamyl phosphate reductase; Region: proA; TIGR00407
1400867008583	putative catalytic cysteine [active]
1400867008584	NADP+-dependent non-phosphorylating glyceraldehyde 3-phosphate dehydrogenase and ALDH family 11; Region: ALDH_F11_NP-GAPDH; cd07082
1400867008585	NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012
1400867008586	tetrameric interface [polypeptide binding]; other site
1400867008587	activator binding site; other site
1400867008588	NADP binding site [chemical binding]; other site
1400867008589	substrate binding site [chemical binding]; other site
1400867008590	catalytic residues [active]
1400867008591	Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021
1400867008592	ATP-binding site [chemical binding]; other site
1400867008593	Gluconate-6-phosphate binding site [chemical binding]; other site
1400867008594	Shikimate kinase; Region: SKI; pfam01202
1400867008595	GntP family permease; Region: GntP_permease; pfam02447
1400867008596	fructuronate transporter; Provisional; Region: PRK10034; cl15264
1400867008597	keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718
1400867008598	KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452
1400867008599	active site
1400867008600	intersubunit interface [polypeptide binding]; other site
1400867008601	catalytic residue [active]
1400867008602	phosphogluconate dehydratase; Validated; Region: PRK09054
1400867008603	6-phosphogluconate dehydratase; Region: edd; TIGR01196
1400867008604	acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180
1400867008605	propionate/acetate kinase; Provisional; Region: PRK12379
1400867008606	phosphate acetyltransferase; Reviewed; Region: PRK05632
1400867008607	DRTGG domain; Region: DRTGG; pfam07085
1400867008608	phosphotransacetylase; Reviewed; Region: eutD; PRK09653
1400867008609	Fumarate hydratase (Fumerase); Region: Fumerase; pfam05681
1400867008610	Fumarase C-terminus; Region: Fumerase_C; pfam05683
1400867008611	Uncharacterized protein conserved in bacteria (DUF2059); Region: DUF2059; pfam09832
1400867008612	Protein of unknown function (DUF2846); Region: DUF2846; pfam11008
1400867008613	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
1400867008614	ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689
1400867008615	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1400867008616	Walker A motif; other site
1400867008617	ATP binding site [chemical binding]; other site
1400867008618	Walker B motif; other site
1400867008619	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
1400867008620	Clp protease; Region: CLP_protease; pfam00574
1400867008621	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
1400867008622	oligomer interface [polypeptide binding]; other site
1400867008623	active site residues [active]
1400867008624	trigger factor; Provisional; Region: tig; PRK01490
1400867008625	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
1400867008626	Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698
1400867008627	Outer membrane receptor for monomeric catechols [Inorganic ion transport and metabolism]; Region: Fiu; COG4774
1400867008628	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
1400867008629	N-terminal plug; other site
1400867008630	ligand-binding site [chemical binding]; other site
1400867008631	Fe(II)-dependent oxygenase superfamily protein; Provisional; Region: PRK05467
1400867008632	2-isopropylmalate synthase; Validated; Region: PRK03739
1400867008633	Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942
1400867008634	active site
1400867008635	catalytic residues [active]
1400867008636	metal binding site [ion binding]; metal-binding site
1400867008637	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917
1400867008638	homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175
1400867008639	homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392
1400867008640	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1400867008641	S-adenosylmethionine binding site [chemical binding]; other site
1400867008642	Sel1-like repeats; Region: SEL1; smart00671
1400867008643	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
1400867008644	Sel1-like repeats; Region: SEL1; smart00671
1400867008645	NTPase/HAM1.  This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515
1400867008646	active site
1400867008647	dimerization interface [polypeptide binding]; other site
1400867008648	Membrane transport protein; Region: Mem_trans; cl09117
1400867008649	mttA/Hcf106 family; Region: MttA_Hcf106; cl00788
1400867008650	twin arginine-targeting protein translocase TatB; Region: tatB; TIGR01410
1400867008651	Sec-independent protein translocase protein (TatC); Region: TatC; cl00521
1400867008652	Bacterial protein of unknown function (DUF839); Region: DUF839; pfam05787
1400867008653	Predicted phosphatase [General function prediction only]; Region: PhoX; COG3211
1400867008654	NRDE protein; Region: NRDE; cl01315
1400867008655	prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK12437
1400867008656	thymidylate synthase; Reviewed; Region: thyA; PRK01827
1400867008657	Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351
1400867008658	dimerization interface [polypeptide binding]; other site
1400867008659	active site
1400867008660	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
1400867008661	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209
1400867008662	folate binding site [chemical binding]; other site
1400867008663	NADP+ binding site [chemical binding]; other site
1400867008664	Domain of unknown function (DUF4105); Region: DUF4105; pfam13387
1400867008665	methionine sulfoxide reductase A; Provisional; Region: PRK14054
1400867008666	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
1400867008667	Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472
1400867008668	Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811
1400867008669	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
1400867008670	formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027
1400867008671	N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875
1400867008672	Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648
1400867008673	putative active site [active]
1400867008674	putative substrate binding site [chemical binding]; other site
1400867008675	putative cosubstrate binding site; other site
1400867008676	catalytic site [active]
1400867008677	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1400867008678	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1400867008679	Bacterial transcriptional repressor; Region: TetR; pfam13972
1400867008680	aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381
1400867008681	Coniferyl aldehyde dehydrogenase-like; Region: ALDH_CALDH_CalB; cd07133
1400867008682	NAD(P) binding site [chemical binding]; other site
1400867008683	catalytic residues [active]
1400867008684	50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359
1400867008685	50S ribosomal protein L33; Validated; Region: rpmG; PRK00595
1400867008686	putative cation:proton antiport protein; Provisional; Region: PRK10669
1400867008687	Kef-type K+ transport system, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: RosB; COG4651
1400867008688	TrkA-N domain; Region: TrkA_N; pfam02254
1400867008689	ASCH domain; Region: ASCH; pfam04266
1400867008690	RNA-binding proteins (RRM domain) [General function prediction only]; Region: COG0724
1400867008691	RNA recognition motif; Region: RRM; smart00360
1400867008692	Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
1400867008693	Part of AAA domain; Region: AAA_19; pfam13245
1400867008694	Family description; Region: UvrD_C_2; pfam13538
1400867008695	Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247
1400867008696	DNA topoisomerase I subunit omega; Validated; Region: PRK07561
1400867008697	TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I.   Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363
1400867008698	active site
1400867008699	interdomain interaction site; other site
1400867008700	putative metal-binding site [ion binding]; other site
1400867008701	nucleotide binding site [chemical binding]; other site
1400867008702	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
1400867008703	domain I; other site
1400867008704	DNA binding groove [nucleotide binding]
1400867008705	phosphate binding site [ion binding]; other site
1400867008706	domain II; other site
1400867008707	domain III; other site
1400867008708	nucleotide binding site [chemical binding]; other site
1400867008709	catalytic site [active]
1400867008710	domain IV; other site
1400867008711	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
1400867008712	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
1400867008713	Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272
1400867008714	Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272
1400867008715	Ammonium Transporter Family; Region: Ammonium_transp; cl03012
1400867008716	Predicted transcriptional regulators [Transcription]; Region: COG1733
1400867008717	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
1400867008718	Arginate lyase and other MDR family members; Region: AL_MDR; cd08252
1400867008719	zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817
1400867008720	putative NAD(P) binding site [chemical binding]; other site
1400867008721	dimer interface [polypeptide binding]; other site
1400867008722	SlyX; Region: SlyX; pfam04102
1400867008723	ABC transporter ATPase component; Reviewed; Region: PRK11147
1400867008724	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1400867008725	Walker A/P-loop; other site
1400867008726	ATP binding site [chemical binding]; other site
1400867008727	Q-loop/lid; other site
1400867008728	ABC transporter signature motif; other site
1400867008729	Walker B; other site
1400867008730	D-loop; other site
1400867008731	H-loop/switch region; other site
1400867008732	ABC transporter; Region: ABC_tran_2; pfam12848
1400867008733	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1400867008734	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
1400867008735	Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279
1400867008736	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
1400867008737	putative acyl-acceptor binding pocket; other site
1400867008738	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1400867008739	This family is most closely related to the GT1 family of glycosyltransferases. WavL in Vibrio cholerae has been shown to be involved in the biosynthesis of the lipopolysaccharide core; Region: GT1_WavL_like; cd03819
1400867008740	putative ADP-binding pocket [chemical binding]; other site
1400867008741	glutamate/aspartate:proton symporter; Provisional; Region: gltP; PRK11283
1400867008742	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
1400867008743	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
1400867008744	putative catalytic site [active]
1400867008745	putative metal binding site [ion binding]; other site
1400867008746	putative phosphate binding site [ion binding]; other site
1400867008747	aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK06598
1400867008748	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
1400867008749	FimV N-terminal domain; Region: FimV_core; TIGR03505
1400867008750	Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963
1400867008751	active site
1400867008752	homodimer interface [polypeptide binding]; other site
1400867008753	tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021
1400867008754	Eukaryotic and bacterial pseudouridine synthases similar to E.  coli TruA; Region: PseudoU_synth_EcTruA; cd02570
1400867008755	dimerization interface 3.5A [polypeptide binding]; other site
1400867008756	active site
1400867008757	Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625
1400867008758	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1400867008759	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1400867008760	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
1400867008761	rRNA binding site [nucleotide binding]; other site
1400867008762	predicted 30S ribosome binding site; other site
1400867008763	Protein of unknown function (DUF1311); Region: DUF1311; cl01530
1400867008764	3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772
1400867008765	tartrate dehydrogenase; Region: TTC; TIGR02089
1400867008766	isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641
1400867008767	Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577
1400867008768	substrate binding site [chemical binding]; other site
1400867008769	3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402
1400867008770	3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583
1400867008771	substrate binding site [chemical binding]; other site
1400867008772	ligand binding site [chemical binding]; other site
1400867008773	Predicted membrane protein (DUF2061); Region: DUF2061; pfam09834
1400867008774	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1400867008775	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1400867008776	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
1400867008777	dimerization interface [polypeptide binding]; other site
1400867008778	Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560
1400867008779	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
1400867008780	Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671
1400867008781	putative active site [active]
1400867008782	Ap4A binding site [chemical binding]; other site
1400867008783	nudix motif; other site
1400867008784	putative metal binding site [ion binding]; other site
1400867008785	Signal transduction protein containing GAF and PtsI domains [Signal transduction mechanisms]; Region: PtsP; COG3605
1400867008786	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
1400867008787	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
1400867008788	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
1400867008789	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
1400867008790	catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061
1400867008791	Heme-dependent peroxidases similar to plant peroxidases; Region: plant_peroxidase_like; cl00196
1400867008792	heme binding site [chemical binding]; other site
1400867008793	C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200
1400867008794	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
1400867008795	Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706
1400867008796	DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906
1400867008797	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1400867008798	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1400867008799	dimerization interface [polypeptide binding]; other site
1400867008800	Protein of unknown function (DUF1345); Region: DUF1345; pfam07077
1400867008801	GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972
1400867008802	GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046
1400867008803	putative C-terminal domain interface [polypeptide binding]; other site
1400867008804	putative GSH binding site (G-site) [chemical binding]; other site
1400867008805	putative dimer interface [polypeptide binding]; other site
1400867008806	C-terminal, alpha helical domain of an unknown subfamily 8 of Glutathione S-transferases; Region: GST_C_8; cd03207
1400867008807	dimer interface [polypeptide binding]; other site
1400867008808	N-terminal domain interface [polypeptide binding]; other site
1400867008809	putative substrate binding pocket (H-site) [chemical binding]; other site
1400867008810	Predicted transcriptional regulator [Transcription]; Region: COG2378
1400867008811	HTH domain; Region: HTH_11; pfam08279
1400867008812	WYL domain; Region: WYL; pfam13280
1400867008813	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
1400867008814	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1400867008815	motif II; other site
1400867008816	23S rRNA pseudouridylate synthase C; Provisional; Region: PRK11025
1400867008817	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1400867008818	RNA binding surface [nucleotide binding]; other site
1400867008819	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
1400867008820	active site
1400867008821	Ribonucleases G and E [Translation, ribosomal structure and biogenesis]; Region: CafA; COG1530
1400867008822	S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453
1400867008823	homodimer interface [polypeptide binding]; other site
1400867008824	oligonucleotide binding site [chemical binding]; other site
1400867008825	long-chain-acyl-CoA synthetase; Validated; Region: PRK08279
1400867008826	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1400867008827	Fatty acid transport proteins (FATP) play dual roles as fatty acid transporters and its activation enzymes; Region: FATP_FACS; cd05940
1400867008828	acyl-activating enzyme (AAE) consensus motif; other site
1400867008829	putative AMP binding site [chemical binding]; other site
1400867008830	putative active site [active]
1400867008831	putative CoA binding site [chemical binding]; other site
1400867008832	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1400867008833	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1400867008834	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472
1400867008835	putative effector binding pocket; other site
1400867008836	putative dimerization interface [polypeptide binding]; other site
1400867008837	short chain dehydrogenase; Provisional; Region: PRK12744
1400867008838	tetrahydroxynaphthalene/trihydroxynaphthalene reductase-like, classical (c) SDRs; Region: THN_reductase-like_SDR_c; cd05362
1400867008839	NADP binding site [chemical binding]; other site
1400867008840	homodimer interface [polypeptide binding]; other site
1400867008841	active site
1400867008842	substrate binding site [chemical binding]; other site
1400867008843	HemN family oxidoreductase; Provisional; Region: PRK05660
1400867008844	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1400867008845	FeS/SAM binding site; other site
1400867008846	HemN C-terminal domain; Region: HemN_C; pfam06969
1400867008847	Protein of unknown function, DUF606; Region: DUF606; pfam04657
1400867008848	multidrug efflux protein; Reviewed; Region: PRK01766
1400867008849	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131
1400867008850	cation binding site [ion binding]; other site
1400867008851	Dibenzothiophene (DBT) desulfurization enzyme C; Region: DszC; cd01163
1400867008852	sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022
1400867008853	Flavin binding site [chemical binding]; other site
1400867008854	sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022
1400867008855	Dibenzothiophene (DBT) desulfurization enzyme C; Region: DszC; cd01163
1400867008856	Flavin binding site [chemical binding]; other site
1400867008857	Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661
1400867008858	ABC1 family; Region: ABC1; pfam03109
1400867008859	50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678
1400867008860	HopJ type III effector protein; Region: HopJ; pfam08888
1400867008861	chromosome condensation membrane protein; Provisional; Region: PRK14196
1400867008862	Glutathione-dependent formaldehyde-activating enzyme; Region: GFA; pfam04828
1400867008863	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1400867008864	uncharacterized flavoprotein, PP_4765 family; Region: flavo_PP4765; TIGR03862
1400867008865	Putative methyltransferase; Region: Methyltransf_4; cl17290
1400867008866	Domain of unknown function (DUF329); Region: DUF329; pfam03884
1400867008867	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
1400867008868	ferrochelatase; Reviewed; Region: hemH; PRK00035
1400867008869	Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411
1400867008870	C-terminal domain interface [polypeptide binding]; other site
1400867008871	active site
1400867008872	Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419
1400867008873	active site
1400867008874	N-terminal domain interface [polypeptide binding]; other site
1400867008875	Domain of unknown function (DUF4062); Region: DUF4062; pfam13271
1400867008876	glutamate racemase; Provisional; Region: PRK00865
1400867008877	aspartate racemase; Region: asp_race; TIGR00035
1400867008878	Protein of unknown function (DUF1285); Region: DUF1285; pfam06938
1400867008879	Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644
1400867008880	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1400867008881	Electron transfer flavoprotein-ubiquinone oxidoreductase; Region: ETF_QO; pfam05187
1400867008882	Ferredoxin-like protein [Energy production and conversion]; Region: FixX; COG2440
1400867008883	SirA (also known as UvrY,  and YhhP) belongs to a family of two-component response regulators that controls secondary metabolism and virulence. The other member of this two-component system is a sensor kinase called BarA which phosphorylates SirA.  A...; Region: SirA; cd03423
1400867008884	CPxP  motif; other site
1400867008885	FOG: CBS domain [General function prediction only]; Region: COG0517
1400867008886	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
1400867008887	Transporter associated domain; Region: CorC_HlyC; smart01091
1400867008888	apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302
1400867008889	Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571
1400867008890	putative active site [active]
1400867008891	catalytic triad [active]
1400867008892	putative dimer interface [polypeptide binding]; other site
1400867008893	tRNA-binding-domain-containing CsaA-like proteins. CsaA is a molecular chaperone with export related activities. CsaA has a putative tRNA binding activity. The functional unit of CsaA is a homodimer and this domain acts as a dimerization domain; Region: tRNA_bind_CsaA; cd02798
1400867008894	dimer interface [polypeptide binding]; other site
1400867008895	putative tRNA-binding site [nucleotide binding]; other site
1400867008896	type II secretion system protein G; Region: typeII_sec_gspG; TIGR01710
1400867008897	Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334
1400867008898	type II secretion system protein F; Region: GspF; TIGR02120
1400867008899	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
1400867008900	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
1400867008901	primosome assembly protein PriA; Validated; Region: PRK05580
1400867008902	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1400867008903	ATP binding site [chemical binding]; other site
1400867008904	putative Mg++ binding site [ion binding]; other site
1400867008905	helicase superfamily c-terminal domain; Region: HELICc; smart00490
1400867008906	ATP-binding site [chemical binding]; other site
1400867008907	glutathione-regulated potassium-efflux system protein KefC; Provisional; Region: PRK03562
1400867008908	transporter, monovalent cation:proton antiporter-2 (CPA2) family; Region: 2a37; TIGR00932
1400867008909	TrkA-N domain; Region: TrkA_N; pfam02254
1400867008910	Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114
1400867008911	Heat shock protein 33 (Hsp33):  Cytosolic protein that acts as a molecular chaperone under oxidative conditions.  In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498
1400867008912	dimerization interface [polypeptide binding]; other site
1400867008913	domain crossover interface; other site
1400867008914	redox-dependent activation switch; other site
1400867008915	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
1400867008916	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
1400867008917	chaperone protein DnaJ; Region: DnaJ_bact; TIGR02349
1400867008918	HSP70 interaction site [polypeptide binding]; other site
1400867008919	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
1400867008920	substrate binding site [polypeptide binding]; other site
1400867008921	dimer interface [polypeptide binding]; other site
1400867008922	MerR HTH family regulatory protein; Region: MerR_2; pfam13591
1400867008923	CorA-like Mg2+ transporter protein; Region: CorA; pfam01544
1400867008924	Thermotoga maritima CorA-like family; Region: TmCorA-like; cd12822
1400867008925	oligomer interface [polypeptide binding]; other site
1400867008926	metal binding site [ion binding]; metal-binding site
1400867008927	metal binding site [ion binding]; metal-binding site
1400867008928	putative Cl binding site [ion binding]; other site
1400867008929	aspartate ring; other site
1400867008930	basic sphincter; other site
1400867008931	hydrophobic gate; other site
1400867008932	periplasmic entrance; other site
1400867008933	polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824
1400867008934	Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363
1400867008935	RNase E interface [polypeptide binding]; other site
1400867008936	trimer interface [polypeptide binding]; other site
1400867008937	Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726
1400867008938	Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364
1400867008939	RNase E interface [polypeptide binding]; other site
1400867008940	trimer interface [polypeptide binding]; other site
1400867008941	active site
1400867008942	Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393
1400867008943	putative nucleic acid binding region [nucleotide binding]; other site
1400867008944	G-X-X-G motif; other site
1400867008945	S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase  is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472
1400867008946	RNA binding site [nucleotide binding]; other site
1400867008947	domain interface; other site
1400867008948	Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353
1400867008949	16S/18S rRNA binding site [nucleotide binding]; other site
1400867008950	S13e-L30e interaction site [polypeptide binding]; other site
1400867008951	25S rRNA binding site [nucleotide binding]; other site
1400867008952	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
1400867008953	Beta-lactamase; Region: Beta-lactamase; pfam00144
1400867008954	AAA domain; Region: AAA_30; pfam13604
1400867008955	AAA domain; Region: AAA_22; pfam13401
1400867008956	Family description; Region: UvrD_C_2; pfam13538
1400867008957	Part of AAA domain; Region: AAA_19; pfam13245
1400867008958	ATP-dependent exoDNAse (exonuclease V) beta subunit (contains helicase and exonuclease domains) [DNA replication, recombination, and repair]; Region: RecB; COG1074
1400867008959	Family description; Region: UvrD_C_2; pfam13538
1400867008960	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
1400867008961	Exodeoxyribonuclease V, gamma subunit; Region: Exonuc_V_gamma; pfam04257
1400867008962	exonuclease V subunit gamma; Provisional; Region: recC; PRK11069
1400867008963	Uncharacterized protein/domain associated with GTPases [Function unknown]; Region: COG3597
1400867008964	Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971
1400867008965	polyphosphate:AMP phosphotransferase; Region: poly_P_AMP_trns; TIGR03708
1400867008966	Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971
1400867008967	Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226
1400867008968	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1400867008969	S-adenosylmethionine binding site [chemical binding]; other site
1400867008970	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4627
1400867008971	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3165
1400867008972	ABC1 family; Region: ABC1; cl17513
1400867008973	2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982
1400867008974	2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654
1400867008975	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
1400867008976	bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759
1400867008977	phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051
1400867008978	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534
1400867008979	metal binding site [ion binding]; metal-binding site
1400867008980	Family description; Region: UvrD_C_2; pfam13538
1400867008981	AAA domain; Region: AAA_23; pfam13476
1400867008982	putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12648
1400867008983	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
1400867008984	Domain of unknown function (DUF4040); Region: DUF4040; pfam13244
1400867008985	Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111
1400867008986	putative monovalent cation/H+ antiporter subunit B; Reviewed; Region: PRK12573
1400867008987	putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK09094
1400867008988	putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12666
1400867008989	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
1400867008990	putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK08965
1400867008991	Multiple resistance and pH regulation protein F (MrpF / PhaF); Region: MrpF_PhaF; cl09154
1400867008992	putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12674
1400867008993	ribosome-binding factor A; Provisional; Region: PRK13816
1400867008994	translation initiation factor IF-2; Region: IF-2; TIGR00487
1400867008995	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
1400867008996	Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887
1400867008997	G1 box; other site
1400867008998	putative GEF interaction site [polypeptide binding]; other site
1400867008999	GTP/Mg2+ binding site [chemical binding]; other site
1400867009000	Switch I region; other site
1400867009001	G2 box; other site
1400867009002	G3 box; other site
1400867009003	Switch II region; other site
1400867009004	G4 box; other site
1400867009005	G5 box; other site
1400867009006	This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702
1400867009007	Translation-initiation factor 2; Region: IF-2; pfam11987
1400867009008	mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692
1400867009009	transcription elongation factor NusA; Validated; Region: nusA; PRK09202
1400867009010	NusA N-terminal domain; Region: NusA_N; pfam08529
1400867009011	S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455
1400867009012	RNA binding site [nucleotide binding]; other site
1400867009013	homodimer interface [polypeptide binding]; other site
1400867009014	NusA-like KH domain; Region: KH_5; pfam13184
1400867009015	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
1400867009016	G-X-X-G motif; other site
1400867009017	transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954
1400867009018	transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954
1400867009019	Sm and related proteins; Region: Sm_like; cl00259
1400867009020	ribosome maturation protein RimP; Reviewed; Region: PRK00092
1400867009021	Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734
1400867009022	putative oligomer interface [polypeptide binding]; other site
1400867009023	putative RNA binding site [nucleotide binding]; other site
1400867009024	Preprotein translocase SecG subunit; Region: SecG; pfam03840
1400867009025	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
1400867009026	triosephosphate isomerase; Provisional; Region: PRK14567
1400867009027	substrate binding site [chemical binding]; other site
1400867009028	dimer interface [polypeptide binding]; other site
1400867009029	catalytic triad [active]
1400867009030	type IV-A pilus assembly ATPase PilB; Region: type_IV_pilB; TIGR02538
1400867009031	Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157
1400867009032	PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129
1400867009033	Walker A motif; other site
1400867009034	ATP binding site [chemical binding]; other site
1400867009035	Walker B motif; other site
1400867009036	Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459
1400867009037	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
1400867009038	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
1400867009039	Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989
1400867009040	Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750
1400867009041	Type IV leader peptidase family; Region: Peptidase_A24; pfam01478
1400867009042	Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237
1400867009043	Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022
1400867009044	CoA-binding site [chemical binding]; other site
1400867009045	ATP-binding [chemical binding]; other site
1400867009046	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
1400867009047	EamA-like transporter family; Region: EamA; pfam00892
1400867009048	23S rRNA (guanosine-2'-O-)-methyltransferase; Provisional; Region: PRK11181
1400867009049	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032
1400867009050	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
1400867009051	Protein of unknown function (DUF1255); Region: DUF1255; pfam06865
1400867009052	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1400867009053	binding surface
1400867009054	Tetratricopeptide repeat; Region: TPR_16; pfam13432
1400867009055	TPR motif; other site
1400867009056	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497
1400867009057	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
1400867009058	Walker A/P-loop; other site
1400867009059	ATP binding site [chemical binding]; other site
1400867009060	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
1400867009061	ABC transporter signature motif; other site
1400867009062	Walker B; other site
1400867009063	D-loop; other site
1400867009064	H-loop/switch region; other site
1400867009065	Uncharacterized ACR, COG1678; Region: DUF179; pfam02622
1400867009066	Holliday junction resolvase-like protein; Reviewed; Region: PRK00109
1400867009067	Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566
1400867009068	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
1400867009069	HlyD family secretion protein; Region: HlyD_3; pfam13437
1400867009070	Protein of unknown function (DUF1656); Region: DUF1656; pfam07869
1400867009071	Fusaric acid resistance protein family; Region: FUSC; pfam04632
1400867009072	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
1400867009073	IclR helix-turn-helix domain; Region: HTH_IclR; cl17605
1400867009074	Transcriptional regulator [Transcription]; Region: IclR; COG1414
1400867009075	Bacterial transcriptional regulator; Region: IclR; pfam01614
1400867009076	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_2; pfam13532
1400867009077	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1400867009078	Helix-turn-helix domain; Region: HTH_18; pfam12833
1400867009079	Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350
1400867009080	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
1400867009081	DNA binding site [nucleotide binding]
1400867009082	active site
1400867009083	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453
1400867009084	Thioesterase-like superfamily; Region: 4HBT_3; pfam13622
1400867009085	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445
1400867009086	active site
1400867009087	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II; cd00556
1400867009088	active site
1400867009089	dimer interface [polypeptide binding]; other site
1400867009090	excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558
1400867009091	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
1400867009092	GIY-YIG motif/motif A; other site
1400867009093	active site
1400867009094	catalytic site [active]
1400867009095	putative DNA binding site [nucleotide binding]; other site
1400867009096	metal binding site [ion binding]; metal-binding site
1400867009097	UvrB/uvrC motif; Region: UVR; pfam02151
1400867009098	UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459
1400867009099	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220
1400867009100	Protein of unknown function (DUF1311); Region: DUF1311; cl01530
1400867009101	Aspartyl/asparaginyl beta-hydroxylase and related dioxygenases [Posttranslational modification, protein turnover, chaperones]; Region: COG3555
1400867009102	multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadB; PRK11730
1400867009103	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
1400867009104	substrate binding site [chemical binding]; other site
1400867009105	oxyanion hole (OAH) forming residues; other site
1400867009106	trimer interface [polypeptide binding]; other site
1400867009107	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
1400867009108	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
1400867009109	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
1400867009110	3-ketoacyl-CoA thiolase; Reviewed; Region: fadA; PRK08947
1400867009111	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
1400867009112	dimer interface [polypeptide binding]; other site
1400867009113	active site
1400867009114	hypothetical protein; Provisional; Region: PRK10215
1400867009115	Predicted esterase of the alpha/beta hydrolase fold [General function prediction only]; Region: COG3545
1400867009116	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
1400867009117	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
1400867009118	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
1400867009119	DNA binding residues [nucleotide binding]
1400867009120	Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761
1400867009121	DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024
1400867009122	catalytic residues [active]
1400867009123	heat shock protein 90; Provisional; Region: PRK05218
1400867009124	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1400867009125	ATP binding site [chemical binding]; other site
1400867009126	Mg2+ binding site [ion binding]; other site
1400867009127	G-X-G motif; other site
1400867009128	Protein of unknown function (DUF1311); Region: DUF1311; pfam07007
1400867009129	Outer membrane protein W [Cell envelope biogenesis, outer membrane]; Region: OmpW; COG3047
1400867009130	Predicted permease [General function prediction only]; Region: COG2056
1400867009131	Na+-H+ antiporter family; Region: Na_H_antiport_2; pfam13726
1400867009132	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
1400867009133	Putative serine esterase (DUF676); Region: DUF676; pfam05057
1400867009134	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
1400867009135	active site 2 [active]
1400867009136	active site 1 [active]
1400867009137	RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997
1400867009138	DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086
1400867009139	RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663
1400867009140	RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983
1400867009141	RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000
1400867009142	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
1400867009143	Rpb1 - Rpb6 interaction site [polypeptide binding]; other site
1400867009144	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
1400867009145	Rpb1 - Rpb6 interaction site [polypeptide binding]; other site
1400867009146	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
1400867009147	DNA binding site [nucleotide binding]
1400867009148	Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site
1400867009149	DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405
1400867009150	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585
1400867009151	RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561
1400867009152	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
1400867009153	RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562
1400867009154	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
1400867009155	RPB1 interaction site [polypeptide binding]; other site
1400867009156	RPB11 interaction site [polypeptide binding]; other site
1400867009157	RPB10 interaction site [polypeptide binding]; other site
1400867009158	RPB3 interaction site [polypeptide binding]; other site
1400867009159	Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387
1400867009160	core dimer interface [polypeptide binding]; other site
1400867009161	peripheral dimer interface [polypeptide binding]; other site
1400867009162	L10 interface [polypeptide binding]; other site
1400867009163	L11 interface [polypeptide binding]; other site
1400867009164	putative EF-Tu interaction site [polypeptide binding]; other site
1400867009165	putative EF-G interaction site [polypeptide binding]; other site
1400867009166	Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797
1400867009167	23S rRNA interface [nucleotide binding]; other site
1400867009168	Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site
1400867009169	Ribosomal protein L1.  The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA.  In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403
1400867009170	mRNA/rRNA interface [nucleotide binding]; other site
1400867009171	50S ribosomal protein L11; Validated; Region: rplK; PRK00140
1400867009172	Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349
1400867009173	23S rRNA interface [nucleotide binding]; other site
1400867009174	L7/L12 interface [polypeptide binding]; other site
1400867009175	putative thiostrepton binding site; other site
1400867009176	L25 interface [polypeptide binding]; other site
1400867009177	transcription antitermination protein NusG; Validated; Region: nusG; PRK05609
1400867009178	Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891
1400867009179	putative homodimer interface [polypeptide binding]; other site
1400867009180	NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091
1400867009181	heterodimer interface [polypeptide binding]; other site
1400867009182	homodimer interface [polypeptide binding]; other site
1400867009183	N-Utilization Substance G (NusG) N-terminal (NGN) domain Superfamily; Region: NGN; cl02766
1400867009184	preprotein translocase subunit SecE; Reviewed; Region: secE; PRK05740
1400867009185	elongation factor Tu; Reviewed; Region: PRK00049
1400867009186	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
1400867009187	G1 box; other site
1400867009188	GEF interaction site [polypeptide binding]; other site
1400867009189	GTP/Mg2+ binding site [chemical binding]; other site
1400867009190	Switch I region; other site
1400867009191	G2 box; other site
1400867009192	G3 box; other site
1400867009193	Switch II region; other site
1400867009194	G4 box; other site
1400867009195	G5 box; other site
1400867009196	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
1400867009197	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
1400867009198	Antibiotic Binding Site [chemical binding]; other site
1400867009199	anthranilate synthase component I; Provisional; Region: PRK13565
1400867009200	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
1400867009201	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
1400867009202	phosphoglycolate phosphatase; Provisional; Region: PRK13222
1400867009203	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1400867009204	motif II; other site
1400867009205	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
1400867009206	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
1400867009207	phosphopeptide binding site; other site
1400867009208	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
1400867009209	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
1400867009210	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
1400867009211	pilus (MSHA type) biogenesis protein MshL; Region: pilus_MshL; TIGR02519
1400867009212	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
1400867009213	type II secretion system protein C; Region: typeII_sec_gspC; TIGR01713
1400867009214	Type IV pilus biogenesis; Region: Pilus_PilP; pfam11356
1400867009215	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
1400867009216	Type II secretion system (T2SS), protein N; Region: T2SN; pfam01203
1400867009217	H-NS histone family; Region: Histone_HNS; pfam00816
1400867009218	Domain in histone-like proteins of HNS family; Region: HNS; smart00528
1400867009219	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
1400867009220	active site
1400867009221	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
1400867009222	Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587
1400867009223	active site
1400867009224	porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072
1400867009225	Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494
1400867009226	domain interfaces; other site
1400867009227	active site
1400867009228	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
1400867009229	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1400867009230	active site
1400867009231	phosphorylation site [posttranslational modification]
1400867009232	intermolecular recognition site; other site
1400867009233	dimerization interface [polypeptide binding]; other site
1400867009234	LytTr DNA-binding domain; Region: LytTR; smart00850
1400867009235	Histidine kinase; Region: His_kinase; pfam06580
1400867009236	argininosuccinate lyase; Provisional; Region: PRK00855
1400867009237	Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359
1400867009238	active sites [active]
1400867009239	tetramer interface [polypeptide binding]; other site
1400867009240	oxidative damage protection protein; Provisional; Region: PRK05408
1400867009241	transcriptional regulator PhoU; Provisional; Region: PRK11115
1400867009242	PhoU domain; Region: PhoU; pfam01895
1400867009243	PhoU domain; Region: PhoU; pfam01895
1400867009244	type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844
1400867009245	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
1400867009246	EamA-like transporter family; Region: EamA; pfam00892
1400867009247	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1400867009248	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1400867009249	thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284
1400867009250	ThiC-associated domain; Region: ThiC-associated; pfam13667
1400867009251	Thiamine biosynthesis protein ThiC [Coenzyme metabolism]; Region: ThiC; COG0422
1400867009252	ADP-ribose pyrophosphatase NudF; Provisional; Region: nudF; PRK10729
1400867009253	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
1400867009254	dimer interface [polypeptide binding]; other site
1400867009255	ADP-ribose binding site [chemical binding]; other site
1400867009256	active site
1400867009257	nudix motif; other site
1400867009258	metal binding site [ion binding]; metal-binding site
1400867009259	Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402
1400867009260	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
1400867009261	active site
1400867009262	metal binding site [ion binding]; metal-binding site
1400867009263	hexamer interface [polypeptide binding]; other site
1400867009264	RNA polymerase-binding protein DksA; Region: dksA; TIGR02420
1400867009265	glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710
1400867009266	active site
1400867009267	nucleotide binding site [chemical binding]; other site
1400867009268	HIGH motif; other site
1400867009269	KMSKS motif; other site
1400867009270	cell division protein FtsW; Region: ftsW; TIGR02614
1400867009271	UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK03803
1400867009272	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
1400867009273	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
1400867009274	Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370
1400867009275	Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879
1400867009276	G1 box; other site
1400867009277	GTP/Mg2+ binding site [chemical binding]; other site
1400867009278	Switch I region; other site
1400867009279	G2 box; other site
1400867009280	G3 box; other site
1400867009281	Switch II region; other site
1400867009282	G4 box; other site
1400867009283	G5 box; other site
1400867009284	Nucleoside recognition; Region: Gate; pfam07670
1400867009285	Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664
1400867009286	Nucleoside recognition; Region: Gate; pfam07670
1400867009287	FeoA domain; Region: FeoA; pfam04023
1400867009288	site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283
1400867009289	XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798
1400867009290	active site
1400867009291	Int/Topo IB signature motif; other site
1400867009292	Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651
1400867009293	DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020
1400867009294	dimerization domain [polypeptide binding]; other site
1400867009295	dimer interface [polypeptide binding]; other site
1400867009296	catalytic residues [active]
1400867009297	homoserine dehydrogenase; Provisional; Region: PRK06349
1400867009298	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
1400867009299	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
1400867009300	ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881
1400867009301	threonine synthase; Reviewed; Region: PRK06721
1400867009302	Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of  threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563
1400867009303	homodimer interface [polypeptide binding]; other site
1400867009304	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1400867009305	catalytic residue [active]
1400867009306	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
1400867009307	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768
1400867009308	response regulator; Provisional; Region: PRK09483
1400867009309	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1400867009310	active site
1400867009311	phosphorylation site [posttranslational modification]
1400867009312	intermolecular recognition site; other site
1400867009313	dimerization interface [polypeptide binding]; other site
1400867009314	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1400867009315	DNA binding residues [nucleotide binding]
1400867009316	dimerization interface [polypeptide binding]; other site
1400867009317	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
1400867009318	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
1400867009319	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
1400867009320	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1400867009321	dimer interface [polypeptide binding]; other site
1400867009322	phosphorylation site [posttranslational modification]
1400867009323	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1400867009324	ATP binding site [chemical binding]; other site
1400867009325	Mg2+ binding site [ion binding]; other site
1400867009326	G-X-G motif; other site
1400867009327	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
1400867009328	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1400867009329	active site
1400867009330	phosphorylation site [posttranslational modification]
1400867009331	intermolecular recognition site; other site
1400867009332	dimerization interface [polypeptide binding]; other site
1400867009333	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1400867009334	Walker A motif; other site
1400867009335	ATP binding site [chemical binding]; other site
1400867009336	Walker B motif; other site
1400867009337	arginine finger; other site
1400867009338	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
1400867009339	Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793
1400867009340	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
1400867009341	PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cd00136
1400867009342	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
1400867009343	Catalytic dyad [active]
1400867009344	phosphoglyceromutase; Provisional; Region: PRK05434
1400867009345	Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696
1400867009346	Predicted permeases [General function prediction only]; Region: COG0795; cl12074
1400867009347	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
1400867009348	Predicted permeases [General function prediction only]; Region: COG0795; cl12074
1400867009349	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
1400867009350	multifunctional aminopeptidase A; Provisional; Region: PRK00913
1400867009351	Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433
1400867009352	interface (dimer of trimers) [polypeptide binding]; other site
1400867009353	Substrate-binding/catalytic site; other site
1400867009354	Zn-binding sites [ion binding]; other site
1400867009355	DNA polymerase III chi subunit, HolC; Region: DNA_pol3_chi; pfam04364
1400867009356	riboflavin synthase subunit alpha; Provisional; Region: PRK09289
1400867009357	Lumazine binding domain; Region: Lum_binding; pfam00677
1400867009358	Lumazine binding domain; Region: Lum_binding; pfam00677
1400867009359	Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG3392
1400867009360	D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; cl17344
1400867009361	bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase; Provisional; Region: ribD; PRK10786
1400867009362	Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284
1400867009363	catalytic motif [active]
1400867009364	Zn binding site [ion binding]; other site
1400867009365	RibD C-terminal domain; Region: RibD_C; cl17279
1400867009366	transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464
1400867009367	ATP cone domain; Region: ATP-cone; pfam03477
1400867009368	Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004
1400867009369	Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347
1400867009370	Nitrogen regulatory protein P-II; Region: P-II; smart00938
1400867009371	Membrane fusogenic activity; Region: BMFP; pfam04380
1400867009372	Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606
1400867009373	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
1400867009374	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1400867009375	Walker A motif; other site
1400867009376	ATP binding site [chemical binding]; other site
1400867009377	Walker B motif; other site
1400867009378	arginine finger; other site
1400867009379	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335
1400867009380	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1400867009381	DNA-binding site [nucleotide binding]; DNA binding site
1400867009382	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
1400867009383	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1400867009384	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1400867009385	homodimer interface [polypeptide binding]; other site
1400867009386	catalytic residue [active]
1400867009387	class II aldolase/adducin domain protein; Provisional; Region: PRK07090
1400867009388	intersubunit interface [polypeptide binding]; other site
1400867009389	active site
1400867009390	Zn2+ binding site [ion binding]; other site
1400867009391	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
1400867009392	Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408
1400867009393	inhibitor site; inhibition site
1400867009394	active site
1400867009395	dimer interface [polypeptide binding]; other site
1400867009396	catalytic residue [active]
1400867009397	Bacterial protein of unknown function (Gcw_chp); Region: Gcw_chp; cl09901
1400867009398	outer membrane porin, OprD family; Region: OprD; pfam03573
1400867009399	Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412
1400867009400	dimer interface [polypeptide binding]; other site
1400867009401	substrate binding site [chemical binding]; other site
1400867009402	metal binding sites [ion binding]; metal-binding site
1400867009403	MAPEG family; Region: MAPEG; cl09190
1400867009404	Long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07059
1400867009405	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1400867009406	Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936
1400867009407	acyl-activating enzyme (AAE) consensus motif; other site
1400867009408	putative AMP binding site [chemical binding]; other site
1400867009409	putative active site [active]
1400867009410	putative CoA binding site [chemical binding]; other site
1400867009411	DNA topoisomerase IV subunit A; Validated; Region: PRK05561
1400867009412	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
1400867009413	CAP-like domain; other site
1400867009414	active site
1400867009415	primary dimer interface [polypeptide binding]; other site
1400867009416	benzoate transport; Region: 2A0115; TIGR00895
1400867009417	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1400867009418	putative substrate translocation pore; other site
1400867009419	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1400867009420	Predicted membrane protein [Function unknown]; Region: COG2860
1400867009421	UPF0126 domain; Region: UPF0126; pfam03458
1400867009422	UPF0126 domain; Region: UPF0126; pfam03458
1400867009423	hypothetical protein; Provisional; Region: PRK01752
1400867009424	SEC-C motif; Region: SEC-C; pfam02810
1400867009425	Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861
1400867009426	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
1400867009427	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
1400867009428	Transporter associated domain; Region: CorC_HlyC; smart01091
1400867009429	Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695
1400867009430	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1400867009431	putative transporter; Provisional; Region: PRK10504
1400867009432	putative substrate translocation pore; other site
1400867009433	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1400867009434	Uncharacterized bacterial muramidase containing a glycosyl hydrolase family 25 (GH25) catalytic domain. Endo-N-acetylmuramidases are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis...; Region: GH25_muramidase_1; cd06413
1400867009435	active site
1400867009436	Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183
1400867009437	DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586
1400867009438	active site
1400867009439	DNA polymerase IV; Validated; Region: PRK02406
1400867009440	DNA binding site [nucleotide binding]
1400867009441	This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function.  The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150
1400867009442	homotrimer interaction site [polypeptide binding]; other site
1400867009443	putative active site [active]
1400867009444	Protein of unknown function (DUF2726); Region: DUF2726; pfam10881
1400867009445	hypothetical protein; Provisional; Region: PRK01254
1400867009446	Radical SAM N-terminal; Region: Radical_SAM_N; pfam08497
1400867009447	Radical SAM N-terminal; Region: Radical_SAM_N; pfam08497
1400867009448	Domain of unknown function (DUF3362); Region: DUF3362; pfam11842
1400867009449	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4222
1400867009450	Class II Chelatase: a family of ATP-independent monomeric or homodimeric enzymes that catalyze the insertion of metal into protoporphyrin rings. This family includes protoporphyrin IX ferrochelatase (HemH), sirohydrochlorin ferrochelatase (SirB) and the...; Region: Chelatase_Class_II; cl02784
1400867009451	Cu(I)-responsive transcriptional regulator; Region: CueR; TIGR02044
1400867009452	Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg6; cd04781
1400867009453	DNA binding residues [nucleotide binding]
1400867009454	putative dimer interface [polypeptide binding]; other site
1400867009455	putative metal binding residues [ion binding]; other site
1400867009456	Protein of unknown function (DUF2938); Region: DUF2938; pfam11158
1400867009457	Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655
1400867009458	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
1400867009459	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
1400867009460	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
1400867009461	N-acetyl-D-glucosamine binding site [chemical binding]; other site
1400867009462	catalytic residue [active]
1400867009463	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
1400867009464	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
1400867009465	dimer interface [polypeptide binding]; other site
1400867009466	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1400867009467	catalytic residue [active]
1400867009468	Acetyltransferase (GNAT) domain; Region: Acetyltransf_9; pfam13527
1400867009469	Coenzyme A binding pocket [chemical binding]; other site
1400867009470	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1400867009471	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1400867009472	Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; pfam09995
1400867009473	TonB-dependent copper receptor; Region: TonB-copper; TIGR01778
1400867009474	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
1400867009475	N-terminal plug; other site
1400867009476	ligand-binding site [chemical binding]; other site
1400867009477	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
1400867009478	active site
1400867009479	catalytic residues [active]
1400867009480	metal binding site [ion binding]; metal-binding site
1400867009481	Uncharacterized protein containing LysM domain [Function unknown]; Region: XkdP; COG1652
1400867009482	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1400867009483	DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481
1400867009484	DNA protecting protein DprA; Region: dprA; TIGR00732
1400867009485	Telomere recombination; Region: Sua5_yciO_yrdC; cl00305
1400867009486	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
1400867009487	EamA-like transporter family; Region: EamA; pfam00892
1400867009488	EamA-like transporter family; Region: EamA; pfam00892
1400867009489	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1400867009490	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1400867009491	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
1400867009492	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1400867009493	putative substrate translocation pore; other site
1400867009494	Helix-turn-helix domain; Region: HTH_18; pfam12833
1400867009495	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1400867009496	Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340
1400867009497	catalytic residues [active]
1400867009498	dimer interface [polypeptide binding]; other site
1400867009499	Protein of unknown function (DUF2846); Region: DUF2846; pfam11008
1400867009500	F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571
1400867009501	mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152
1400867009502	gamma subunit interface [polypeptide binding]; other site
1400867009503	epsilon subunit interface [polypeptide binding]; other site
1400867009504	LBP interface [polypeptide binding]; other site
1400867009505	F0F1 ATP synthase subunit beta; Validated; Region: PRK09280
1400867009506	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
1400867009507	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
1400867009508	alpha subunit interaction interface [polypeptide binding]; other site
1400867009509	Walker A motif; other site
1400867009510	ATP binding site [chemical binding]; other site
1400867009511	Walker B motif; other site
1400867009512	inhibitor binding site; inhibition site
1400867009513	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
1400867009514	mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151
1400867009515	core domain interface [polypeptide binding]; other site
1400867009516	delta subunit interface [polypeptide binding]; other site
1400867009517	epsilon subunit interface [polypeptide binding]; other site
1400867009518	F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281
1400867009519	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
1400867009520	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
1400867009521	Walker A motif; other site
1400867009522	ATP binding site [chemical binding]; other site
1400867009523	Walker B motif; other site
1400867009524	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
1400867009525	F0F1 ATP synthase subunit delta; Validated; Region: PRK05758
1400867009526	ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213
1400867009527	F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711
1400867009528	F0F1 ATP synthase subunit B; Validated; Region: PRK05759
1400867009529	F0F1 ATP synthase subunit C; Validated; Region: PRK06876
1400867009530	F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356
1400867009531	F0F1 ATP synthase subunit A; Validated; Region: PRK05815
1400867009532	F0F1 ATP synthase subunit I; Validated; Region: PRK05760
1400867009533	Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297
1400867009534	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
1400867009535	intersubunit interface [polypeptide binding]; other site
1400867009536	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cl17326
1400867009537	metal binding site 2 [ion binding]; metal-binding site
1400867009538	putative DNA binding helix; other site
1400867009539	metal binding site 1 [ion binding]; metal-binding site
1400867009540	dimer interface [polypeptide binding]; other site
1400867009541	structural Zn2+ binding site [ion binding]; other site
1400867009542	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
1400867009543	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1400867009544	Walker A/P-loop; other site
1400867009545	ATP binding site [chemical binding]; other site
1400867009546	Q-loop/lid; other site
1400867009547	ABC transporter signature motif; other site
1400867009548	Walker B; other site
1400867009549	D-loop; other site
1400867009550	H-loop/switch region; other site
1400867009551	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
1400867009552	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1400867009553	ABC-ATPase subunit  interface; other site
1400867009554	dimer interface [polypeptide binding]; other site
1400867009555	putative PBP binding regions; other site
1400867009556	LysE type translocator; Region: LysE; cl00565
1400867009557	Dyp-type peroxidase family; Region: Dyp_perox; cl01067
1400867009558	malate dehydrogenase; Provisional; Region: PRK13529
1400867009559	Malic enzyme, N-terminal domain; Region: malic; pfam00390
1400867009560	NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312
1400867009561	NAD(P) binding site [chemical binding]; other site
1400867009562	Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016
1400867009563	Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018
1400867009564	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
1400867009565	active site
1400867009566	HIGH motif; other site
1400867009567	nucleotide binding site [chemical binding]; other site
1400867009568	catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
1400867009569	KMSK motif region; other site
1400867009570	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
1400867009571	tRNA binding surface [nucleotide binding]; other site
1400867009572	anticodon binding site; other site
1400867009573	Sporulation related domain; Region: SPOR; pfam05036
1400867009574	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
1400867009575	GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046
1400867009576	putative C-terminal domain interface [polypeptide binding]; other site
1400867009577	putative GSH binding site (G-site) [chemical binding]; other site
1400867009578	putative dimer interface [polypeptide binding]; other site
1400867009579	C-terminal, alpha helical domain of GTT1-like Glutathione S-transferases; Region: GST_C_GTT1_like; cd03189
1400867009580	putative N-terminal domain interface [polypeptide binding]; other site
1400867009581	putative dimer interface [polypeptide binding]; other site
1400867009582	putative substrate binding pocket (H-site) [chemical binding]; other site
1400867009583	OsmC-like protein; Region: OsmC; pfam02566
1400867009584	Pirin; Region: Pirin; pfam02678
1400867009585	Pirin-related protein [General function prediction only]; Region: COG1741
1400867009586	Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726
1400867009587	Domain of Unknown Function with PDB structure (DUF3861); Region: DUF3861; pfam12977
1400867009588	Predicted transcriptional regulators [Transcription]; Region: COG1695
1400867009589	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
1400867009590	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
1400867009591	active site
1400867009592	NTP binding site [chemical binding]; other site
1400867009593	metal binding triad [ion binding]; metal-binding site
1400867009594	antibiotic binding site [chemical binding]; other site
1400867009595	Domain of unknown function (DUF4111); Region: DUF4111; pfam13427
1400867009596	GMP synthase; Reviewed; Region: guaA; PRK00074
1400867009597	Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742
1400867009598	AMP/PPi binding site [chemical binding]; other site
1400867009599	candidate oxyanion hole; other site
1400867009600	catalytic triad [active]
1400867009601	potential glutamine specificity residues [chemical binding]; other site
1400867009602	The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997
1400867009603	ATP Binding subdomain [chemical binding]; other site
1400867009604	Ligand Binding sites [chemical binding]; other site
1400867009605	Dimerization subdomain; other site
1400867009606	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399
1400867009607	Predicted membrane protein [Function unknown]; Region: COG2259
1400867009608	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
1400867009609	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
1400867009610	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
1400867009611	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
1400867009612	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
1400867009613	P-loop; other site
1400867009614	Magnesium ion binding site [ion binding]; other site
1400867009615	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
1400867009616	Magnesium ion binding site [ion binding]; other site
1400867009617	Invasion gene expression up-regulator, SirB; Region: SirB; cl01184
1400867009618	Stress-induced morphogen (activity unknown) [Signal transduction mechanisms]; Region: BolA; COG0271
1400867009619	Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091
1400867009620	4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648
1400867009621	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1400867009622	NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370
1400867009623	NAD(P) binding site [chemical binding]; other site
1400867009624	active site
1400867009625	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
1400867009626	Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303
1400867009627	catalytic site [active]
1400867009628	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
1400867009629	hydrophobic ligand binding site; other site
1400867009630	Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033
1400867009631	Protein of unknown function (DUF1329); Region: DUF1329; pfam07044
1400867009632	Condensation domain; Region: Condensation; pfam00668
1400867009633	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
1400867009634	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
1400867009635	The adenylation domain of nonribosomal peptide synthetases (NRPS), including salinosporamide A polyketide synthase; Region: A_NRPS_Ta1_like; cd12116
1400867009636	acyl-activating enzyme (AAE) consensus motif; other site
1400867009637	AMP binding site [chemical binding]; other site
1400867009638	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1400867009639	Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319
1400867009640	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
1400867009641	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
1400867009642	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
1400867009643	active site
1400867009644	acyl-CoA synthetase; Validated; Region: PRK05850
1400867009645	Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931
1400867009646	acyl-activating enzyme (AAE) consensus motif; other site
1400867009647	active site
1400867009648	DNA-binding transcriptional activator SdiA; Provisional; Region: PRK10188
1400867009649	Autoinducer binding domain; Region: Autoind_bind; pfam03472
1400867009650	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1400867009651	DNA binding residues [nucleotide binding]
1400867009652	dimerization interface [polypeptide binding]; other site
1400867009653	Autoinducer synthetase; Region: Autoind_synth; cl17404
1400867009654	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1400867009655	metabolite-proton symporter; Region: 2A0106; TIGR00883
1400867009656	putative substrate translocation pore; other site
1400867009657	3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617
1400867009658	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
1400867009659	substrate binding site [chemical binding]; other site
1400867009660	oxyanion hole (OAH) forming residues; other site
1400867009661	trimer interface [polypeptide binding]; other site
1400867009662	2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766
1400867009663	enoyl-CoA hydratase; Provisional; Region: PRK05862
1400867009664	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
1400867009665	substrate binding site [chemical binding]; other site
1400867009666	oxyanion hole (OAH) forming residues; other site
1400867009667	trimer interface [polypeptide binding]; other site
1400867009668	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
1400867009669	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
1400867009670	active site
1400867009671	Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365
1400867009672	Domain of unknown function (DUF3448); Region: DUF3448; pfam11930
1400867009673	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1400867009674	acyl-activating enzyme (AAE) consensus motif; other site
1400867009675	AMP binding site [chemical binding]; other site
1400867009676	active site
1400867009677	CoA binding site [chemical binding]; other site
1400867009678	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
1400867009679	3-hydroxyisobutyrate dehydrogenase; Region: HIBADH; TIGR01692
1400867009680	Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085
1400867009681	methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722
1400867009682	tetrameric interface [polypeptide binding]; other site
1400867009683	NAD binding site [chemical binding]; other site
1400867009684	catalytic residues [active]
1400867009685	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1400867009686	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1400867009687	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1400867009688	dimerization interface [polypeptide binding]; other site
1400867009689	D-alanine/D-serine/glycine permease; Provisional; Region: PRK11049
1400867009690	D-alanine/D-serine/glycine permease; Provisional; Region: PRK11049
1400867009691	This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function.  The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150
1400867009692	homotrimer interaction site [polypeptide binding]; other site
1400867009693	putative active site [active]
1400867009694	alanine racemase; Reviewed; Region: dadX; PRK03646
1400867009695	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827
1400867009696	active site
1400867009697	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
1400867009698	substrate binding site [chemical binding]; other site
1400867009699	catalytic residues [active]
1400867009700	dimer interface [polypeptide binding]; other site
1400867009701	D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711
1400867009702	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1400867009703	mRNA stabilisation; Region: mRNA_stabil; pfam13929
1400867009704	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
1400867009705	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1400867009706	putative DNA binding site [nucleotide binding]; other site
1400867009707	putative Zn2+ binding site [ion binding]; other site
1400867009708	AsnC family; Region: AsnC_trans_reg; pfam01037
1400867009709	Predicted membrane protein [Function unknown]; Region: COG3503
1400867009710	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
1400867009711	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
1400867009712	N-terminal plug; other site
1400867009713	ligand-binding site [chemical binding]; other site
1400867009714	SnoaL-like domain; Region: SnoaL_2; pfam12680
1400867009715	Protein of unknown function (DUF1260); Region: DUF1260; pfam06877
1400867009716	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
1400867009717	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
1400867009718	active site
1400867009719	Predicted membrane protein [Function unknown]; Region: COG4420
1400867009720	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1400867009721	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1400867009722	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1400867009723	NAD(P) binding site [chemical binding]; other site
1400867009724	active site
1400867009725	Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525
1400867009726	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
1400867009727	AAA domain; Region: AAA_28; pfam13521
1400867009728	Pseudomonas avirulence D protein (AvrD); Region: AvrD; pfam05655
1400867009729	Arginate lyase and other MDR family members; Region: AL_MDR; cd08252
1400867009730	zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817
1400867009731	putative NAD(P) binding site [chemical binding]; other site
1400867009732	dimer interface [polypeptide binding]; other site
1400867009733	Uncharacterized protein conserved in bacteria [Function unknown]; Region: VgrG; COG3501
1400867009734	Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954
1400867009735	Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717
1400867009736	Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296
1400867009737	Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; pfam10106
1400867009738	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
1400867009739	Sel1-like repeats; Region: SEL1; smart00671
1400867009740	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1400867009741	binding surface
1400867009742	TPR motif; other site
1400867009743	Sel1-like repeats; Region: SEL1; smart00671
1400867009744	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
1400867009745	dimer interface [polypeptide binding]; other site
1400867009746	active site
1400867009747	Domain of unknown function (DUF4126); Region: DUF4126; pfam13548
1400867009748	Predicted NTPase (NACHT family) [Signal transduction mechanisms]; Region: COG5635
1400867009749	2-methylisocitrate dehydratase, Fe/S-dependent; Region: 2met_isocit_dHY; TIGR02333
1400867009750	Aconitase A catalytic domain; Region: AcnA_IRP; cd01586
1400867009751	substrate binding site [chemical binding]; other site
1400867009752	ligand binding site [chemical binding]; other site
1400867009753	Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215
1400867009754	substrate binding site [chemical binding]; other site
1400867009755	Citrate synthase [Energy production and conversion]; Region: GltA; COG0372
1400867009756	methylcitrate synthase; Provisional; Region: PRK12351
1400867009757	oxalacetate binding site [chemical binding]; other site
1400867009758	citrylCoA binding site [chemical binding]; other site
1400867009759	coenzyme A binding site [chemical binding]; other site
1400867009760	catalytic triad [active]
1400867009761	Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714
1400867009762	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
1400867009763	tetramer interface [polypeptide binding]; other site
1400867009764	active site
1400867009765	Mg2+/Mn2+ binding site [ion binding]; other site
1400867009766	Transcriptional regulators [Transcription]; Region: GntR; COG1802
1400867009767	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1400867009768	DNA-binding site [nucleotide binding]; DNA binding site
1400867009769	FCD domain; Region: FCD; pfam07729
1400867009770	aromatic amino acid aminotransferase; Provisional; Region: PRK09257
1400867009771	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1400867009772	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1400867009773	homodimer interface [polypeptide binding]; other site
1400867009774	catalytic residue [active]
1400867009775	D-lactate dehydrogenase; Provisional; Region: PRK11183
1400867009776	FAD binding domain; Region: FAD_binding_4; pfam01565
1400867009777	D-lactate dehydrogenase, membrane binding; Region: Lact-deh-memb; pfam09330
1400867009778	L-lactate dehydrogenase; Provisional; Region: lldD; PRK11197
1400867009779	Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809
1400867009780	active site
1400867009781	substrate binding site [chemical binding]; other site
1400867009782	FMN binding site [chemical binding]; other site
1400867009783	putative catalytic residues [active]
1400867009784	DNA-binding transcriptional repressor LldR; Provisional; Region: PRK10421
1400867009785	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1400867009786	DNA-binding site [nucleotide binding]; DNA binding site
1400867009787	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
1400867009788	L-lactate permease; Provisional; Region: PRK10420
1400867009789	glycolate transporter; Provisional; Region: PRK09695
1400867009790	phosphomannomutase CpsG; Provisional; Region: PRK15414
1400867009791	The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089
1400867009792	active site
1400867009793	substrate binding site [chemical binding]; other site
1400867009794	metal binding site [ion binding]; metal-binding site
1400867009795	Sulfatase; Region: Sulfatase; pfam00884
1400867009796	glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179
1400867009797	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015
1400867009798	active site
1400867009799	dimer interface [polypeptide binding]; other site
1400867009800	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016
1400867009801	dimer interface [polypeptide binding]; other site
1400867009802	active site
1400867009803	Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004
1400867009804	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
1400867009805	UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984
1400867009806	Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541
1400867009807	active site
1400867009808	tetramer interface; other site
1400867009809	Bacterial sugar transferase; Region: Bac_transf; pfam02397
1400867009810	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
1400867009811	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
1400867009812	Probable Catalytic site; other site
1400867009813	metal-binding site
1400867009814	RfbF is a putative dTDP-rhamnosyl transferase; Region: GT2_RfbF_like; cd02526
1400867009815	L-rhamnosyltransferase; Region: rhamnosyltran; TIGR01556
1400867009816	Ligand binding site; other site
1400867009817	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1400867009818	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
1400867009819	dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908
1400867009820	G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538
1400867009821	glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207
1400867009822	substrate binding site; other site
1400867009823	tetramer interface; other site
1400867009824	dTDP-4-dehydrorhamnose reductase; Provisional; Region: PRK09987
1400867009825	dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254
1400867009826	NADP binding site [chemical binding]; other site
1400867009827	active site
1400867009828	putative substrate binding site [chemical binding]; other site
1400867009829	dTDP-glucose 4,6 dehydratase; Provisional; Region: PRK10084
1400867009830	dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246
1400867009831	NAD binding site [chemical binding]; other site
1400867009832	substrate binding site [chemical binding]; other site
1400867009833	homodimer interface [polypeptide binding]; other site
1400867009834	active site
1400867009835	UDP-glucose 6-dehydrogenase; Provisional; Region: PRK15057
1400867009836	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
1400867009837	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
1400867009838	UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984
1400867009839	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
1400867009840	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
1400867009841	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
1400867009842	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_d; cd04196
1400867009843	Probable Catalytic site; other site
1400867009844	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
1400867009845	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
1400867009846	active site
1400867009847	Vi polysaccharide biosynthesis protein TviB; Provisional; Region: PRK15182
1400867009848	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
1400867009849	UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984
1400867009850	Periplasmic protein involved in polysaccharide export, contains    SLBB domain of b-grasp fold [Cell wall/membrane/envelope biogenesis]; Region: Wza; COG1596
1400867009851	Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563
1400867009852	Low molecular weight phosphatase family; Region: LMWPc; cd00115
1400867009853	Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451
1400867009854	active site
1400867009855	tyrosine kinase; Provisional; Region: PRK11519
1400867009856	Chain length determinant protein; Region: Wzz; pfam02706
1400867009857	G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807
1400867009858	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
1400867009859	Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346
1400867009860	FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545
1400867009861	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
1400867009862	Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346
1400867009863	FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545
1400867009864	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
1400867009865	Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728
1400867009866	MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123
1400867009867	N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023
1400867009868	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
1400867009869	amidase catalytic site [active]
1400867009870	Zn binding residues [ion binding]; other site
1400867009871	substrate binding site [chemical binding]; other site
1400867009872	quinolinate phosphoribosyltransferase; Validated; Region: PRK09016
1400867009873	Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572
1400867009874	dimerization interface [polypeptide binding]; other site
1400867009875	active site
1400867009876	phospholipase C, phosphocholine-specific, Pseudomonas-type; Region: PC_PLC; TIGR03396
1400867009877	Phosphoesterase family; Region: Phosphoesterase; pfam04185
1400867009878	Domain of unknown function (DUF756); Region: DUF756; pfam05506
1400867009879	Domain of unknown function (DUF756); Region: DUF756; pfam05506
1400867009880	ribonuclease PH; Reviewed; Region: rph; PRK00173
1400867009881	Ribonuclease PH; Region: RNase_PH_bact; cd11362
1400867009882	hexamer interface [polypeptide binding]; other site
1400867009883	active site
1400867009884	Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239
1400867009885	The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506
1400867009886	putative di-iron ligands [ion binding]; other site
1400867009887	Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_2; cd06216
1400867009888	FMN reductase; Validated; Region: fre; PRK08051
1400867009889	FAD binding pocket [chemical binding]; other site
1400867009890	FAD binding motif [chemical binding]; other site
1400867009891	phosphate binding motif [ion binding]; other site
1400867009892	beta-alpha-beta structure motif; other site
1400867009893	NAD binding pocket [chemical binding]; other site
1400867009894	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
1400867009895	catalytic loop [active]
1400867009896	iron binding site [ion binding]; other site
1400867009897	DNA-binding transcriptional repressor FabR; Provisional; Region: PRK11202
1400867009898	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1400867009899	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1400867009900	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1400867009901	DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019
1400867009902	catalytic residues [active]
1400867009903	hinge region; other site
1400867009904	alpha helical domain; other site
1400867009905	bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134
1400867009906	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1400867009907	S-adenosylmethionine binding site [chemical binding]; other site
1400867009908	phosphoglycolate phosphatase; Provisional; Region: PRK13222
1400867009909	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1400867009910	active site
1400867009911	motif I; other site
1400867009912	motif II; other site
1400867009913	putative oxoacyl-(acyl carrier protein) reductase; Provisional; Region: PRK08945
1400867009914	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1400867009915	NAD(P) binding site [chemical binding]; other site
1400867009916	active site
1400867009917	Domain of unknown function (DUF3315); Region: DUF3315; pfam11776
1400867009918	Domain of unknown function (DUF3315); Region: DUF3315; pfam11776
1400867009919	N-acetylglutamate synthase; Validated; Region: PRK05279
1400867009920	AAK_NAGS-ABP: N-acetylglutamate (NAG) kinase-like domain of the NAG Synthase (NAGS) of the arginine-biosynthesis pathway (ABP) found in gamma- and beta-proteobacteria and higher plant chloroplasts. Domain architecture of these NAGS consisted of an...; Region: AAK_NAGS-ABP; cd04237
1400867009921	putative feedback inhibition sensing region; other site
1400867009922	putative nucleotide binding site [chemical binding]; other site
1400867009923	putative substrate binding site [chemical binding]; other site
1400867009924	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1400867009925	Coenzyme A binding pocket [chemical binding]; other site
1400867009926	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
1400867009927	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1400867009928	substrate binding pocket [chemical binding]; other site
1400867009929	membrane-bound complex binding site; other site
1400867009930	hinge residues; other site
1400867009931	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
1400867009932	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1400867009933	substrate binding pocket [chemical binding]; other site
1400867009934	membrane-bound complex binding site; other site
1400867009935	hinge residues; other site
1400867009936	alkanesulfonate monooxygenase; Provisional; Region: PRK00719
1400867009937	Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094
1400867009938	active site
1400867009939	dimer interface [polypeptide binding]; other site
1400867009940	non-prolyl cis peptide bond; other site
1400867009941	insertion regions; other site
1400867009942	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
1400867009943	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1400867009944	putative PBP binding loops; other site
1400867009945	dimer interface [polypeptide binding]; other site
1400867009946	ABC-ATPase subunit interface; other site
1400867009947	aliphatic sulfonates transport ATP-binding subunit; Provisional; Region: ssuB; PRK11247
1400867009948	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
1400867009949	Walker A/P-loop; other site
1400867009950	ATP binding site [chemical binding]; other site
1400867009951	Q-loop/lid; other site
1400867009952	ABC transporter signature motif; other site
1400867009953	Walker B; other site
1400867009954	D-loop; other site
1400867009955	H-loop/switch region; other site
1400867009956	pyrimidine utilization regulatory protein R; Region: RutR; TIGR03613
1400867009957	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1400867009958	YcdC-like protein, C-terminal region; Region: TetR_C_3; pfam08362
1400867009959	Phosphorylase superfamily; Region: PNP_UDP_1; cl00303
1400867009960	Tellurite resistance protein and related permeases [Inorganic ion transport and metabolism]; Region: TehA; COG1275
1400867009961	Tellurite-resistance/Dicarboxylate Transporter (TDT) family includes sulfite sensitivity protein (sulfite efflux pump; SSU1); Region: TDT_SSU1; cd09318
1400867009962	gating phenylalanine in ion channel; other site
1400867009963	bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627
1400867009964	FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064
1400867009965	active site
1400867009966	Riboflavin kinase; Region: Flavokinase; smart00904
1400867009967	isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743
1400867009968	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
1400867009969	active site
1400867009970	HIGH motif; other site
1400867009971	nucleotide binding site [chemical binding]; other site
1400867009972	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
1400867009973	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
1400867009974	active site
1400867009975	KMSKS motif; other site
1400867009976	Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960
1400867009977	tRNA binding surface [nucleotide binding]; other site
1400867009978	anticodon binding site; other site
1400867009979	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
1400867009980	lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376
1400867009981	FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095
1400867009982	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
1400867009983	Predicted flavoprotein [General function prediction only]; Region: COG0431
1400867009984	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
1400867009985	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
1400867009986	Ankyrin repeats (many copies); Region: Ank_4; pfam13637
1400867009987	Ankyrin repeats (many copies); Region: Ank_4; pfam13637
1400867009988	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cl00197
1400867009989	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cl00197
1400867009990	active site
1400867009991	Protein of unknown function (DUF2424); Region: DUF2424; pfam10340
1400867009992	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
1400867009993	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
1400867009994	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
1400867009995	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1400867009996	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1400867009997	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
1400867009998	putative effector binding pocket; other site
1400867009999	dimerization interface [polypeptide binding]; other site
1400867010000	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cl03075
1400867010001	GrpE; Region: GrpE; pfam01025
1400867010002	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
1400867010003	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
1400867010004	dimer interface [polypeptide binding]; other site
1400867010005	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
1400867010006	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
1400867010007	nucleotide binding site [chemical binding]; other site
1400867010008	Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064
1400867010009	active site
1400867010010	Dual-action HEIGH metallo-peptidase; Region: Peptidase_M57; pfam12388
1400867010011	Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064
1400867010012	active site
1400867010013	Transglycosylase SLT domain; Region: SLT_2; pfam13406
1400867010014	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
1400867010015	N-acetyl-D-glucosamine binding site [chemical binding]; other site
1400867010016	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
1400867010017	phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019
1400867010018	ATP-grasp domain; Region: ATP-grasp; pfam02222
1400867010019	AIR carboxylase; Region: AIRC; pfam00731
1400867010020	Protein of unknown function, DUF486; Region: DUF486; cl01236
1400867010021	UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase; Region: mpl; TIGR01081
1400867010022	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
1400867010023	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
1400867010024	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
1400867010025	Bacterial low temperature requirement A protein (LtrA); Region: LtrA; cl01754
1400867010026	PAP2_like proteins, BcrC_like subfamily. Several members of this family have been annotated as bacitracin transport permeases, as it was suspected that they form the permease component of an ABC transporter system. It was shown, however, that BcrC from...; Region: PAP2_BcrC_like; cd03385
1400867010027	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
1400867010028	active site
1400867010029	integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718
1400867010030	Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754
1400867010031	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
1400867010032	Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469
1400867010033	[2Fe-2S] cluster binding site [ion binding]; other site
1400867010034	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
1400867010035	hydrophobic ligand binding site; other site
1400867010036	guanine deaminase; Provisional; Region: PRK09228
1400867010037	Guanine deaminase (GDEase). Guanine deaminase is an aminohydrolase responsible for the conversion of guanine to xanthine and ammonia, the first step to utilize guanine as a nitrogen source. This reaction also removes the guanine base from the pool and...; Region: GDEase; cd01303
1400867010038	active site
1400867010039	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1400867010040	active site
1400867010041	Predicted membrane protein [Function unknown]; Region: COG2261
1400867010042	Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651
1400867010043	DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020
1400867010044	dimerization domain [polypeptide binding]; other site
1400867010045	dimer interface [polypeptide binding]; other site
1400867010046	catalytic residues [active]
1400867010047	Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230
1400867010048	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
1400867010049	Transcriptional regulators RcnR and FrmR, and related domains; this domain family was previously known as part of DUF156; Region: RcnR-FrmR-like_DUF156; cd10153
1400867010050	putative metal binding site [ion binding]; other site
1400867010051	putative homodimer interface [polypeptide binding]; other site
1400867010052	putative homotetramer interface [polypeptide binding]; other site
1400867010053	putative homodimer-homodimer interface [polypeptide binding]; other site
1400867010054	putative allosteric switch controlling residues; other site
1400867010055	tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291
1400867010056	GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396
1400867010057	trmE is a tRNA modification GTPase; Region: trmE; cd04164
1400867010058	G1 box; other site
1400867010059	GTP/Mg2+ binding site [chemical binding]; other site
1400867010060	Switch I region; other site
1400867010061	G2 box; other site
1400867010062	Switch II region; other site
1400867010063	G3 box; other site
1400867010064	G4 box; other site
1400867010065	G5 box; other site
1400867010066	Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631
1400867010067	membrane protein insertase; Provisional; Region: PRK01318
1400867010068	membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592
1400867010069	hypothetical protein; Provisional; Region: PRK14386
1400867010070	Ribonuclease P; Region: Ribonuclease_P; pfam00825
1400867010071	50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399
1400867010072	Phage-related protein, tail component [Function unknown]; Region: COG4733
1400867010073	Putative phage tail protein; Region: Phage-tail_3; pfam13550
1400867010074	Baculovirus polyhedron envelope protein, PEP, C terminus; Region: Baculo_PEP_C; pfam04513
1400867010075	Phage-related protein, tail component [Function unknown]; Region: COG4723
1400867010076	Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding) found in proteins also containing NlpC/P60 domains; Region: MPN_NLPC_P60; cd08073
1400867010077	MPN+ (JAMM) motif; other site
1400867010078	Zinc-binding site [ion binding]; other site
1400867010079	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
1400867010080	NlpC/P60 family; Region: NLPC_P60; cl17555
1400867010081	Phage-related protein [Function unknown]; Region: gp18; COG4672
1400867010082	Phage minor tail protein; Region: Phage_min_tail; cl01940
1400867010083	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
1400867010084	phage tail tape measure protein, lambda family; Region: tape_meas_lam_C; TIGR01541
1400867010085	Manganese-stabilising protein / photosystem II polypeptide; Region: MSP; cl03326
1400867010086	Bacteriophage protein of unknown function (DUF646); Region: DUF646; cl12124
1400867010087	Phage terminase large subunit; Region: Terminase_3; cl12054
1400867010088	Terminase-like family; Region: Terminase_6; pfam03237
1400867010089	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1400867010090	ABC-type ATPase fused to a predicted acetyltransferase domain [General function prediction only]; Region: COG2401
1400867010091	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
1400867010092	catalytic residues [active]
1400867010093	ABC-type transport system involved in cytochrome c biogenesis, ATPase component [Posttranslational modification, protein turnover, chaperones]; Region: CcmA; COG4133
1400867010094	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267
1400867010095	Walker A/P-loop; other site
1400867010096	ATP binding site [chemical binding]; other site
1400867010097	Q-loop/lid; other site
1400867010098	ABC transporter signature motif; other site
1400867010099	Walker B; other site
1400867010100	D-loop; other site
1400867010101	H-loop/switch region; other site
1400867010102	ParB-like nuclease domain; Region: ParBc; pfam02195
1400867010103	Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475
1400867010104	ParB-like nuclease domain; Region: ParBc; pfam02195
1400867010105	Type III restriction enzyme, res subunit; Region: ResIII; pfam04851
1400867010106	DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061
1400867010107	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1400867010108	nucleotide binding region [chemical binding]; other site
1400867010109	ATP-binding site [chemical binding]; other site
1400867010110	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1400867010111	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
1400867010112	Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737
1400867010113	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
1400867010114	Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610
1400867010115	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313
1400867010116	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1400867010117	ATP binding site [chemical binding]; other site
1400867010118	putative Mg++ binding site [ion binding]; other site
1400867010119	GIY-YIG domain of uncharacterized hypothetical protein found in bacteria and archaea; Region: GIY-YIG_unchar_2; cd10447
1400867010120	GIY-YIG motif/motif A; other site
1400867010121	putative active site [active]
1400867010122	putative metal binding site [ion binding]; other site
1400867010123	Domain of unknown function (DUF4357); Region: DUF4357; pfam14267
1400867010124	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
1400867010125	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
1400867010126	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
1400867010127	type I restriction system adenine methylase (hsdM); Region: hsdM; TIGR00497
1400867010128	HsdM N-terminal domain; Region: HsdM_N; pfam12161
1400867010129	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1400867010130	S-adenosylmethionine binding site [chemical binding]; other site
1400867010131	Protein of unknown function (DUF2958); Region: DUF2958; pfam11171
1400867010132	DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847
1400867010133	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
1400867010134	active site
1400867010135	catalytic site [active]
1400867010136	substrate binding site [chemical binding]; other site
1400867010137	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
1400867010138	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
1400867010139	dihydropteroate synthase; Region: DHPS; TIGR01496
1400867010140	DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
1400867010141	substrate binding pocket [chemical binding]; other site
1400867010142	dimer interface [polypeptide binding]; other site
1400867010143	inhibitor binding site; inhibition site
1400867010144	The alpha-D-phosphohexomutase superfamily includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this family include the phosphoglucomutases (PGM1 and PGM2), phosphoglucosamine...; Region: phosphohexomutase; cl03757
1400867010145	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1400867010146	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1400867010147	putative substrate translocation pore; other site
1400867010148	tetracycline repressor protein TetR; Provisional; Region: PRK13756
1400867010149	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1400867010150	Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909
1400867010151	Putative transposase; Region: Y2_Tnp; pfam04986
1400867010152	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316
1400867010153	Integrase core domain; Region: rve; pfam00665
1400867010154	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
1400867010155	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in a group of uncharacterized proteins from bacteria and archaea; Region: NTP-PPase_u4; cd11541
1400867010156	putative metal binding site [ion binding]; other site
1400867010157	Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049
1400867010158	dimer interface [polypeptide binding]; other site
1400867010159	putative radical transfer pathway; other site
1400867010160	diiron center [ion binding]; other site
1400867010161	tyrosyl radical; other site
1400867010162	ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08447
1400867010163	ATP cone domain; Region: ATP-cone; pfam03477
1400867010164	Class I ribonucleotide reductase; Region: RNR_I; cd01679
1400867010165	active site
1400867010166	dimer interface [polypeptide binding]; other site
1400867010167	catalytic residues [active]
1400867010168	effector binding site; other site
1400867010169	R2 peptide binding site; other site
1400867010170	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1400867010171	endonuclease subunit; Provisional; Region: 46; PHA02562
1400867010172	Walker A/P-loop; other site
1400867010173	ATP binding site [chemical binding]; other site
1400867010174	fzo-like conserved region; Region: Fzo_mitofusin; pfam04799
1400867010175	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1400867010176	Walker B; other site
1400867010177	D-loop; other site
1400867010178	H-loop/switch region; other site
1400867010179	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
1400867010180	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
1400867010181	active site
1400867010182	metal binding site [ion binding]; metal-binding site
1400867010183	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
1400867010184	Walker A motif; other site
1400867010185	ATP binding site [chemical binding]; other site
1400867010186	Walker B motif; other site
1400867010187	Hint (Hedgehog/Intein) domain N-terminal region; Region: HintN; smart00306
1400867010188	protein-splicing catalytic site; other site
1400867010189	thioester formation/cholesterol transfer; other site
1400867010190	Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081
1400867010191	protein-splicing catalytic site; other site
1400867010192	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
1400867010193	5'-3' exonuclease, N-terminal resolvase-like domain; Region: 5_3_exonuc_N; pfam02739
1400867010194	PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812
1400867010195	putative active site [active]
1400867010196	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
1400867010197	putative DNA binding site [nucleotide binding]; other site
1400867010198	putative metal binding site [ion binding]; other site
1400867010199	Uracil-DNA glycosylases (UDG) and related enzymes; Region: UDG_like; cl00483
1400867010200	ligand binding site [chemical binding]; other site
1400867010201	active site
1400867010202	NUMOD4 motif; Region: NUMOD4; pfam07463
1400867010203	HNH endonuclease; Region: HNH_3; pfam13392
1400867010204	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393
1400867010205	Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081
1400867010206	DNA polymerase III, alpha subunit [DNA replication, recombination, and repair]; Region: DnaE; COG0587
1400867010207	protein-splicing catalytic site; other site
1400867010208	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III; Region: PHP_PolIIIA; cd07431
1400867010209	PHP domain; Region: PHP; pfam02811
1400867010210	active site
1400867010211	PHP Thumb interface [polypeptide binding]; other site
1400867010212	Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081
1400867010213	protein-splicing catalytic site; other site
1400867010214	thioester formation/cholesterol transfer; other site
1400867010215	AAA domain (dynein-related subfamily); Region: AAA_5; pfam07728
1400867010216	Cobalamin biosynthesis protein CobT; Region: CobT; pfam06213
1400867010217	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
1400867010218	metal ion-dependent adhesion site (MIDAS); other site
1400867010219	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1400867010220	salt bridge; other site
1400867010221	non-specific DNA binding site [nucleotide binding]; other site
1400867010222	sequence-specific DNA binding site [nucleotide binding]; other site
1400867010223	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
1400867010224	active site
1400867010225	catalytic residues [active]
1400867010226	DNA binding site [nucleotide binding]
1400867010227	Int/Topo IB signature motif; other site
1400867010228	CobQ/CobB/MinD/ParA nucleotide binding domain; Region: CbiA; pfam01656
1400867010229	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
1400867010230	P-loop; other site
1400867010231	Magnesium ion binding site [ion binding]; other site
1400867010232	Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194
1400867010233	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190
1400867010234	active site
1400867010235	DNA ligase; Provisional; Region: 30; PHA02587
1400867010236	Adenylation domain of proteins similar to ATP-dependent polynucleotide ligases; Region: Adenylation_DNA_ligase_like; cd06846
1400867010237	active site
1400867010238	The Oligonucleotide/oligosaccharide binding (OB)-fold domain is a DNA-binding module that is part of the catalytic core unit of ATP dependent DNA ligases; Region: OBF_DNA_ligase_family; cl08424
1400867010239	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
1400867010240	Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718
1400867010241	active site
1400867010242	metal binding site [ion binding]; metal-binding site
1400867010243	41 helicase; Provisional; Region: 41; PHA02542
1400867010244	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
1400867010245	Walker A motif; other site
1400867010246	ATP binding site [chemical binding]; other site
1400867010247	Walker B motif; other site
1400867010248	Initiator Replication protein; Region: Rep_3; pfam01051
1400867010249	Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737
1400867010250	catalytic residues [active]
1400867010251	Na+/H+ ion antiporter subunit; Region: MNHE; cl00807