-- dump date 20140618_190928 -- class Genbank::misc_feature -- table misc_feature_note -- id note 871585000001 type I secretion C-terminal target domain (VC_A0849 subclass); Region: T1SS_VCA0849; TIGR03661 871585000002 Domain of unknown function (DUF1975); Region: DUF1975; pfam09318 871585000003 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 871585000004 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 871585000005 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 871585000006 trimer interface [polypeptide binding]; other site 871585000007 active site 871585000008 substrate binding site [chemical binding]; other site 871585000009 CoA binding site [chemical binding]; other site 871585000010 type 2 lantibiotic biosynthesis protein LanM; Region: lanti_2_LanM; TIGR03897 871585000011 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 871585000012 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788 871585000013 catalytic residues [active] 871585000014 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 871585000015 DNA-binding interface [nucleotide binding]; DNA binding site 871585000016 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 871585000017 DNA-binding interface [nucleotide binding]; DNA binding site 871585000018 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 871585000019 dimer interface [polypeptide binding]; other site 871585000020 putative radical transfer pathway; other site 871585000021 diiron center [ion binding]; other site 871585000022 tyrosyl radical; other site 871585000023 Baculovirus hypothetical protein; Region: Baculo_44; pfam04631 871585000024 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07207 871585000025 ATP cone domain; Region: ATP-cone; pfam03477 871585000026 Class I ribonucleotide reductase; Region: RNR_I; cd01679 871585000027 active site 871585000028 dimer interface [polypeptide binding]; other site 871585000029 catalytic residues [active] 871585000030 effector binding site; other site 871585000031 R2 peptide binding site; other site 871585000032 DNA-binding transcriptional regulator RstA; Provisional; Region: PRK10701 871585000033 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 871585000034 active site 871585000035 phosphorylation site [posttranslational modification] 871585000036 intermolecular recognition site; other site 871585000037 dimerization interface [polypeptide binding]; other site 871585000038 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 871585000039 DNA binding site [nucleotide binding] 871585000040 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 871585000041 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 871585000042 dimerization interface [polypeptide binding]; other site 871585000043 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 871585000044 dimer interface [polypeptide binding]; other site 871585000045 phosphorylation site [posttranslational modification] 871585000046 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 871585000047 ATP binding site [chemical binding]; other site 871585000048 Mg2+ binding site [ion binding]; other site 871585000049 G-X-G motif; other site 871585000050 MASE1; Region: MASE1; cl17823 871585000051 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 871585000052 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 871585000053 metal binding site [ion binding]; metal-binding site 871585000054 active site 871585000055 I-site; other site 871585000056 NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602 871585000057 NADH dehydrogenase subunit B; Validated; Region: PRK06411 871585000058 bifunctional NADH:ubiquinone oxidoreductase subunit C/D; Provisional; Region: PRK11742 871585000059 NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961 871585000060 NADH dehydrogenase subunit D; Validated; Region: PRK06075 871585000061 NADH dehydrogenase subunit E; Validated; Region: PRK07539 871585000062 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 871585000063 putative dimer interface [polypeptide binding]; other site 871585000064 [2Fe-2S] cluster binding site [ion binding]; other site 871585000065 NADH dehydrogenase I subunit F; Provisional; Region: PRK11278 871585000066 SLBB domain; Region: SLBB; pfam10531 871585000067 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928 871585000068 NADH dehydrogenase subunit G; Validated; Region: PRK08166 871585000069 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 871585000070 catalytic loop [active] 871585000071 iron binding site [ion binding]; other site 871585000072 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 871585000073 MopB_NDH-1_NuoG2-N7: The second domain of the NuoG subunit (with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex in the respiratory...; Region: MopB_NDH-1_NuoG2-N7; cd02771 871585000074 [4Fe-4S] binding site [ion binding]; other site 871585000075 MopB_CT_NDH-1_NuoG2-N7: C-terminal region of the NuoG-like subunit (of the variant with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex...; Region: MopB_CT_NDH-1_NuoG2-N7; cd02788 871585000076 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 871585000077 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 871585000078 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 871585000079 4Fe-4S binding domain; Region: Fer4; pfam00037 871585000080 NADH:ubiquinone oxidoreductase subunit 6 (chain J) [Energy production and conversion]; Region: NuoJ; COG0839 871585000081 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 871585000082 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 871585000083 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 871585000084 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 871585000085 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 871585000086 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 871585000087 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 871585000088 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 871585000089 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 871585000090 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 871585000091 active site 871585000092 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 871585000093 DNA-binding site [nucleotide binding]; DNA binding site 871585000094 RNA-binding motif; other site 871585000095 putative DNA-binding transcriptional regulator; Provisional; Region: PRK10837 871585000096 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 871585000097 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 871585000098 putative dimerization interface [polypeptide binding]; other site 871585000099 ferredoxin-NADP reductase; Provisional; Region: PRK10926 871585000100 Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195 871585000101 FAD binding pocket [chemical binding]; other site 871585000102 FAD binding motif [chemical binding]; other site 871585000103 phosphate binding motif [ion binding]; other site 871585000104 beta-alpha-beta structure motif; other site 871585000105 NAD binding pocket [chemical binding]; other site 871585000106 Conserved TM helix; Region: TM_helix; pfam05552 871585000107 Conserved TM helix; Region: TM_helix; pfam05552 871585000108 Conserved TM helix; Region: TM_helix; pfam05552 871585000109 Conserved TM helix; Region: TM_helix; pfam05552 871585000110 HI0933-like protein; Region: HI0933_like; pfam03486 871585000111 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 871585000112 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 871585000113 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 871585000114 catalytic residue [active] 871585000115 efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998 871585000116 HlyD family secretion protein; Region: HlyD_3; pfam13437 871585000117 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 871585000118 Major Facilitator Superfamily; Region: MFS_1; pfam07690 871585000119 putative substrate translocation pore; other site 871585000120 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 871585000121 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 871585000122 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 871585000123 EF-hand domain pair; Region: EF_hand_5; pfam13499 871585000124 methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133 871585000125 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 871585000126 active site 871585000127 HIGH motif; other site 871585000128 KMSKS motif; other site 871585000129 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 871585000130 tRNA binding surface [nucleotide binding]; other site 871585000131 anticodon binding site; other site 871585000132 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 871585000133 dimer interface [polypeptide binding]; other site 871585000134 putative tRNA-binding site [nucleotide binding]; other site 871585000135 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 871585000136 potential frameshift: common BLAST hit: gi|184157060|ref|YP_001845399.1| nucleoside phosphorylase 871585000137 Phosphorylase superfamily; Region: PNP_UDP_1; pfam01048 871585000138 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 871585000139 Uncharacterized protein conserved in bacteria (DUF2062); Region: DUF2062; pfam09835 871585000140 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 871585000141 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 871585000142 trimer interface [polypeptide binding]; other site 871585000143 active site 871585000144 tRNA-dihydrouridine synthase C; Provisional; Region: PRK10550 871585000145 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 871585000146 FMN binding site [chemical binding]; other site 871585000147 active site 871585000148 catalytic residues [active] 871585000149 substrate binding site [chemical binding]; other site 871585000150 potential frameshift: common BLAST hit: gi|215484477|ref|YP_002326712.1| Cytochrome C assembly family protein 871585000151 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 871585000152 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 871585000153 signal recognition particle protein; Provisional; Region: PRK10867 871585000154 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 871585000155 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 871585000156 GTP binding site [chemical binding]; other site 871585000157 Signal peptide binding domain; Region: SRP_SPB; pfam02978 871585000158 pantothenate kinase; Reviewed; Region: PRK13322 871585000159 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 871585000160 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 871585000161 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 871585000162 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 871585000163 Transcriptional regulators [Transcription]; Region: GntR; COG1802 871585000164 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 871585000165 DNA-binding site [nucleotide binding]; DNA binding site 871585000166 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 871585000167 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 871585000168 Walker A/P-loop; other site 871585000169 ATP binding site [chemical binding]; other site 871585000170 Q-loop/lid; other site 871585000171 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 871585000172 ABC transporter signature motif; other site 871585000173 Walker B; other site 871585000174 D-loop; other site 871585000175 H-loop/switch region; other site 871585000176 ZipA, C-terminal FtsZ-binding domain; Region: ZipA_C; pfam04354 871585000177 FtsZ protein binding site [polypeptide binding]; other site 871585000178 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 871585000179 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 871585000180 nucleotide binding pocket [chemical binding]; other site 871585000181 K-X-D-G motif; other site 871585000182 catalytic site [active] 871585000183 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 871585000184 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 871585000185 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 871585000186 Dimer interface [polypeptide binding]; other site 871585000187 BRCT sequence motif; other site 871585000188 Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193 871585000189 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 871585000190 heme binding site [chemical binding]; other site 871585000191 ferroxidase pore; other site 871585000192 ferroxidase diiron center [ion binding]; other site 871585000193 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 871585000194 Major Facilitator Superfamily; Region: MFS_1; pfam07690 871585000195 putative substrate translocation pore; other site 871585000196 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 871585000197 alpha,alpha-trehalose-phosphate synthase [UDP-forming]; Region: trehalose_OtsA; TIGR02400 871585000198 active site 871585000199 homotetramer interface [polypeptide binding]; other site 871585000200 Trehalose-phosphatase; Region: Trehalose_PPase; pfam02358 871585000201 trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187; cl17105 871585000202 pimelyl-[acyl-carrier protein] methyl ester esterase; Region: bioH; TIGR01738 871585000203 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 871585000204 adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK06173 871585000205 inhibitor-cofactor binding pocket; inhibition site 871585000206 pyridoxal 5'-phosphate binding site [chemical binding]; other site 871585000207 catalytic residue [active] 871585000208 8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958 871585000209 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 871585000210 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 871585000211 catalytic residue [active] 871585000212 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 871585000213 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 871585000214 S-adenosylmethionine binding site [chemical binding]; other site 871585000215 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 871585000216 AAA domain; Region: AAA_26; pfam13500 871585000217 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 871585000218 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 871585000219 RNA binding surface [nucleotide binding]; other site 871585000220 Pseudouridine synthase, Escherichia coli RluB like; Region: PseudoU_synth_RluB; cd02556 871585000221 probable active site [active] 871585000222 Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079 871585000223 ScpA/B protein; Region: ScpA_ScpB; cl00598 871585000224 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 871585000225 Protein of unknown function, DUF462; Region: DUF462; pfam04315 871585000226 Uncharacterized ACR, COG1399; Region: DUF177; cl00616 871585000227 50S ribosomal protein L32; Validated; Region: rpmF; PRK01110 871585000228 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 871585000229 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 871585000230 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 871585000231 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 871585000232 NAD(P) binding site [chemical binding]; other site 871585000233 homotetramer interface [polypeptide binding]; other site 871585000234 homodimer interface [polypeptide binding]; other site 871585000235 active site 871585000236 acyl carrier protein; Provisional; Region: acpP; PRK00982 871585000237 LysM domain/BON superfamily protein; Provisional; Region: PRK11198 871585000238 BON domain; Region: BON; pfam04972 871585000239 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 871585000240 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 871585000241 dimer interface [polypeptide binding]; other site 871585000242 substrate binding site [chemical binding]; other site 871585000243 ATP binding site [chemical binding]; other site 871585000244 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 871585000245 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 871585000246 motif II; other site 871585000247 3,4-dihydroxy-2-butanone 4-phosphate synthase; Provisional; Region: ribB; PRK03353 871585000248 3,4-dihydroxy-2-butanone 4-phosphate synthase [Coenzyme metabolism]; Region: RibB; COG0108 871585000249 Predicted membrane protein (DUF2157); Region: DUF2157; cl10480 871585000250 Domain of unknown function (DUF4401); Region: DUF4401; pfam14351 871585000251 potential frameshift: common BLAST hit: gi|184157103|ref|YP_001845442.1| membrane-anchored protein 871585000252 GDYXXLXY protein; Region: GDYXXLXY; pfam14345 871585000253 GDYXXLXY protein; Region: GDYXXLXY; cl02066 871585000254 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 871585000255 tetramerization interface [polypeptide binding]; other site 871585000256 active site 871585000257 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 871585000258 putative active site [active] 871585000259 catalytic residue [active] 871585000260 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 871585000261 5S rRNA interface [nucleotide binding]; other site 871585000262 CTC domain interface [polypeptide binding]; other site 871585000263 L16 interface [polypeptide binding]; other site 871585000264 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 871585000265 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 871585000266 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 871585000267 active site 871585000268 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00343 871585000269 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 871585000270 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 871585000271 outer membrane lipoprotein LolB; Provisional; Region: lolB; PRK00022 871585000272 Outer membrane lipoprotein LolB; Region: LolB; pfam03550 871585000273 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 871585000274 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 871585000275 binding surface 871585000276 TPR motif; other site 871585000277 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 871585000278 binding surface 871585000279 TPR motif; other site 871585000280 potential frameshift: common BLAST hit: gi|299771334|ref|YP_003733360.1| glutamyl-tRNA reductase 871585000281 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 871585000282 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 871585000283 tRNA; other site 871585000284 putative tRNA binding site [nucleotide binding]; other site 871585000285 putative NADP binding site [chemical binding]; other site 871585000286 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 871585000287 DNA primase; Validated; Region: dnaG; PRK05667 871585000288 CHC2 zinc finger; Region: zf-CHC2; pfam01807 871585000289 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 871585000290 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 871585000291 active site 871585000292 metal binding site [ion binding]; metal-binding site 871585000293 interdomain interaction site; other site 871585000294 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 871585000295 Outer membrane lipoprotein; Region: YfiO; pfam13525 871585000296 23S rRNA pseudouridine synthase D; Provisional; Region: rluD; PRK11180 871585000297 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 871585000298 RNA binding surface [nucleotide binding]; other site 871585000299 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 871585000300 active site 871585000301 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 871585000302 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 871585000303 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 871585000304 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 871585000305 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 871585000306 SmpB-tmRNA interface; other site 871585000307 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 871585000308 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 871585000309 active site 871585000310 Phosphate-selective porin O and P; Region: Porin_O_P; pfam07396 871585000311 transcriptional activator TtdR; Provisional; Region: PRK09801 871585000312 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 871585000313 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_9; cd08479 871585000314 putative effector binding pocket; other site 871585000315 putative dimerization interface [polypeptide binding]; other site 871585000316 Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473 871585000317 tartrate dehydrogenase; Region: TTC; TIGR02089 871585000318 putative transporter; Provisional; Region: PRK09950 871585000319 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 871585000320 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 871585000321 substrate binding pocket [chemical binding]; other site 871585000322 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 871585000323 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 871585000324 [2Fe-2S] cluster binding site [ion binding]; other site 871585000325 C-terminal catalytic domain of the oxygenase alpha subunit of an uncharacterized subgroup of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C_2; cd08886 871585000326 putative alpha subunit interface [polypeptide binding]; other site 871585000327 putative active site [active] 871585000328 putative substrate binding site [chemical binding]; other site 871585000329 Fe binding site [ion binding]; other site 871585000330 succinic semialdehyde dehydrogenase; Region: PLN02278 871585000331 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 871585000332 tetramerization interface [polypeptide binding]; other site 871585000333 NAD(P) binding site [chemical binding]; other site 871585000334 catalytic residues [active] 871585000335 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 871585000336 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 871585000337 FMN-binding pocket [chemical binding]; other site 871585000338 flavin binding motif; other site 871585000339 phosphate binding motif [ion binding]; other site 871585000340 beta-alpha-beta structure motif; other site 871585000341 NAD binding pocket [chemical binding]; other site 871585000342 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 871585000343 catalytic loop [active] 871585000344 iron binding site [ion binding]; other site 871585000345 NAD synthetase; Provisional; Region: PRK13981 871585000346 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 871585000347 multimer interface [polypeptide binding]; other site 871585000348 active site 871585000349 catalytic triad [active] 871585000350 protein interface 1 [polypeptide binding]; other site 871585000351 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 871585000352 homodimer interface [polypeptide binding]; other site 871585000353 NAD binding pocket [chemical binding]; other site 871585000354 ATP binding pocket [chemical binding]; other site 871585000355 Mg binding site [ion binding]; other site 871585000356 active-site loop [active] 871585000357 Uncharacterized protein family (UPF0093); Region: UPF0093; pfam03653 871585000358 3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK07967 871585000359 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 871585000360 dimer interface [polypeptide binding]; other site 871585000361 active site 871585000362 EcsC protein family; Region: EcsC; pfam12787 871585000363 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 871585000364 S17 interaction site [polypeptide binding]; other site 871585000365 S8 interaction site; other site 871585000366 16S rRNA interaction site [nucleotide binding]; other site 871585000367 streptomycin interaction site [chemical binding]; other site 871585000368 23S rRNA interaction site [nucleotide binding]; other site 871585000369 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 871585000370 30S ribosomal protein S7; Validated; Region: PRK05302 871585000371 elongation factor G; Reviewed; Region: PRK00007 871585000372 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 871585000373 G1 box; other site 871585000374 putative GEF interaction site [polypeptide binding]; other site 871585000375 GTP/Mg2+ binding site [chemical binding]; other site 871585000376 Switch I region; other site 871585000377 G2 box; other site 871585000378 G3 box; other site 871585000379 Switch II region; other site 871585000380 G4 box; other site 871585000381 G5 box; other site 871585000382 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 871585000383 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 871585000384 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 871585000385 elongation factor Tu; Reviewed; Region: PRK00049 871585000386 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 871585000387 G1 box; other site 871585000388 GEF interaction site [polypeptide binding]; other site 871585000389 GTP/Mg2+ binding site [chemical binding]; other site 871585000390 Switch I region; other site 871585000391 G2 box; other site 871585000392 G3 box; other site 871585000393 Switch II region; other site 871585000394 G4 box; other site 871585000395 G5 box; other site 871585000396 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 871585000397 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 871585000398 Antibiotic Binding Site [chemical binding]; other site 871585000399 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687 871585000400 Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118 871585000401 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687 871585000402 Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118 871585000403 ribosomal-protein-alanine N-acetyltransferase; Provisional; Region: rimI; PRK09491 871585000404 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 871585000405 Coenzyme A binding pocket [chemical binding]; other site 871585000406 arginyl-tRNA-protein transferase; Provisional; Region: PRK01305 871585000407 Arginine-tRNA-protein transferase, N terminus; Region: ATE_N; pfam04376 871585000408 Arginine-tRNA-protein transferase, C terminus; Region: ATE_C; pfam04377 871585000409 leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301 871585000410 thioredoxin reductase; Provisional; Region: PRK10262 871585000411 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 871585000412 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 871585000413 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 871585000414 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 871585000415 This domain directs oriented DNA translocation and forms a winged helix structure; Region: Ftsk_gamma; smart00843 871585000416 threonine efflux system; Provisional; Region: PRK10229 871585000417 Domain of unknown function (DUF4234); Region: DUF4234; pfam14018 871585000418 Septum formation topological specificity factor MinE; Region: MinE; pfam03776 871585000419 Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894 871585000420 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 871585000421 Switch I; other site 871585000422 Switch II; other site 871585000423 Septum formation inhibitor [Cell division and chromosome partitioning]; Region: MinC; COG0850 871585000424 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 871585000425 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 871585000426 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; Region: LPLAT_LCLAT1-like; cd07990 871585000427 putative acyl-acceptor binding pocket; other site 871585000428 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 871585000429 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 871585000430 ligand binding site [chemical binding]; other site 871585000431 ATP-dependent DNA helicase Rep; Region: rep; TIGR01074 871585000432 Part of AAA domain; Region: AAA_19; pfam13245 871585000433 Family description; Region: UvrD_C_2; pfam13538 871585000434 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 871585000435 trimer interface [polypeptide binding]; other site 871585000436 active site 871585000437 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 871585000438 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 871585000439 active site 871585000440 substrate binding site [chemical binding]; other site 871585000441 metal binding site [ion binding]; metal-binding site 871585000442 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 871585000443 feedback inhibition sensing region; other site 871585000444 homohexameric interface [polypeptide binding]; other site 871585000445 nucleotide binding site [chemical binding]; other site 871585000446 N-acetyl-L-glutamate binding site [chemical binding]; other site 871585000447 Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; pfam13444 871585000448 Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121 871585000449 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 871585000450 putative active site [active] 871585000451 putative dimer interface [polypeptide binding]; other site 871585000452 Hemerythrin; Region: Hemerythrin; cd12107 871585000453 Fe binding site [ion binding]; other site 871585000454 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 871585000455 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 871585000456 hypothetical protein; Validated; Region: PRK01777 871585000457 Outer membrane lipoprotein OmlA (small protein A) [Cell envelope biogenesis, outer membrane]; Region: OlmA; COG2913 871585000458 SmpA / OmlA family; Region: SmpA_OmlA; pfam04355 871585000459 ferric uptake regulator; Provisional; Region: fur; PRK09462 871585000460 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 871585000461 metal binding site 2 [ion binding]; metal-binding site 871585000462 putative DNA binding helix; other site 871585000463 metal binding site 1 [ion binding]; metal-binding site 871585000464 dimer interface [polypeptide binding]; other site 871585000465 structural Zn2+ binding site [ion binding]; other site 871585000466 Tfp pilus assembly protein, ATPase PilU [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilU; COG5008 871585000467 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 871585000468 Walker A motif; other site 871585000469 ATP binding site [chemical binding]; other site 871585000470 Walker B motif; other site 871585000471 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 871585000472 Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131 871585000473 Walker A motif; other site 871585000474 ATP binding site [chemical binding]; other site 871585000475 Walker B motif; other site 871585000476 Pyridoxal 5-phosphate (PLP)-binding TIM barrel domain of Type III PLP-Dependent Enzymes, Yggs-like proteins; Region: PLPDE_III_Yggs_like; cd06824 871585000477 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 871585000478 catalytic residue [active] 871585000479 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 871585000480 Walker A/P-loop; other site 871585000481 ATP binding site [chemical binding]; other site 871585000482 Q-loop/lid; other site 871585000483 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 871585000484 ABC transporter signature motif; other site 871585000485 Walker B; other site 871585000486 D-loop; other site 871585000487 H-loop/switch region; other site 871585000488 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 871585000489 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 871585000490 active site 871585000491 metal binding site [ion binding]; metal-binding site 871585000492 DNA binding site [nucleotide binding] 871585000493 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 871585000494 OsmC-like protein; Region: OsmC; cl00767 871585000495 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 871585000496 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 871585000497 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 871585000498 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 871585000499 NAD(P) binding site [chemical binding]; other site 871585000500 active site 871585000501 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 871585000502 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 871585000503 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823 871585000504 dimer interface [polypeptide binding]; other site 871585000505 allosteric magnesium binding site [ion binding]; other site 871585000506 active site 871585000507 aspartate-rich active site metal binding site; other site 871585000508 Schiff base residues; other site 871585000509 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 871585000510 CoenzymeA binding site [chemical binding]; other site 871585000511 subunit interaction site [polypeptide binding]; other site 871585000512 PHB binding site; other site 871585000513 efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998 871585000514 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 871585000515 HlyD family secretion protein; Region: HlyD_3; pfam13437 871585000516 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 871585000517 Major Facilitator Superfamily; Region: MFS_1; pfam07690 871585000518 putative substrate translocation pore; other site 871585000519 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 871585000520 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 871585000521 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 871585000522 type I restriction system adenine methylase (hsdM); Region: hsdM; TIGR00497 871585000523 HsdM N-terminal domain; Region: HsdM_N; pfam12161 871585000524 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 871585000525 S-adenosylmethionine binding site [chemical binding]; other site 871585000526 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 871585000527 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 871585000528 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 871585000529 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958 871585000530 Uncharacterized conserved protein [Function unknown]; Region: COG3586 871585000531 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 871585000532 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 871585000533 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 871585000534 ATP binding site [chemical binding]; other site 871585000535 putative Mg++ binding site [ion binding]; other site 871585000536 Tic20-like protein; Region: Tic20; pfam09685 871585000537 outer membrane porin, OprD family; Region: OprD; pfam03573 871585000538 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 871585000539 benzoate transport; Region: 2A0115; TIGR00895 871585000540 putative substrate translocation pore; other site 871585000541 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 871585000542 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 871585000543 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 871585000544 inhibitor site; inhibition site 871585000545 active site 871585000546 dimer interface [polypeptide binding]; other site 871585000547 catalytic residue [active] 871585000548 Transcriptional regulator [Transcription]; Region: LysR; COG0583 871585000549 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 871585000550 The C-teminal substrate binding domain of LysR-like nitrogen assimilation control (NAC) protein, contains the type 2 periplasmic binding fold; Region: PBP2_Nac; cd08433 871585000551 putative dimerization interface [polypeptide binding]; other site 871585000552 RNA polymerase sigma factor; Reviewed; Region: PRK12523 871585000553 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 871585000554 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 871585000555 DNA binding residues [nucleotide binding] 871585000556 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 871585000557 FecR protein; Region: FecR; pfam04773 871585000558 Secretin and TonB N terminus short domain; Region: STN; pfam07660 871585000559 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 871585000560 TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786 871585000561 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 871585000562 TPR repeat; Region: TPR_11; pfam13414 871585000563 Protein of unknown function (DUF560); Region: DUF560; pfam04575 871585000564 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 871585000565 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cd00232 871585000566 heme binding pocket [chemical binding]; other site 871585000567 heme ligand [chemical binding]; other site 871585000568 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2832 871585000569 Protein of unknown function (DUF1275); Region: DUF1275; pfam06912 871585000570 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 871585000571 PGAP1-like protein; Region: PGAP1; pfam07819 871585000572 arginine-ornithine antiporter; Region: arg_ornith_anti; TIGR03810 871585000573 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 871585000574 Homocysteine/selenocysteine methylase (S-methylmethionine-dependent) [Amino acid transport and metabolism]; Region: MHT1; COG2040 871585000575 malate:quinone oxidoreductase; Validated; Region: PRK05257 871585000576 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 871585000577 choline dehydrogenase; Validated; Region: PRK02106 871585000578 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 871585000579 betaine aldehyde dehydrogenase; Provisional; Region: PRK13252 871585000580 NAD+-dependent 4-trimethylaminobutyraldehyde dehydrogenase, ALDH family 9A1; Region: ALDH_F9_TMBADH; cd07090 871585000581 tetrameric interface [polypeptide binding]; other site 871585000582 NAD binding site [chemical binding]; other site 871585000583 catalytic residues [active] 871585000584 transcriptional regulator BetI; Validated; Region: PRK00767 871585000585 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 871585000586 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 871585000587 BCCT family transporter; Region: BCCT; pfam02028 871585000588 choline transport protein BetT; Provisional; Region: PRK09928 871585000589 Multiple antibiotic transporter [Intracellular trafficking and secretion]; Region: MarC; COG2095 871585000590 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 871585000591 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 871585000592 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 871585000593 C4-dicarboxylate transporter DctA; Reviewed; Region: PRK13027 871585000594 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 871585000595 YaeQ protein; Region: YaeQ; pfam07152 871585000596 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 871585000597 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 871585000598 poly-beta-1,6-N-acetyl-D-glucosamine N-deacetylase PgaB; Region: deacetyl_PgaB; TIGR03938 871585000599 N-terminal putative catalytic polysaccharide deacetylase domain of bacterial poly-beta-1,6-N-acetyl-D-glucosamine N-deacetylase PgaB, and similar proteins; Region: CE4_PgaB_5s; cd10964 871585000600 putative active site [active] 871585000601 putative metal binding site [ion binding]; other site 871585000602 N-glycosyltransferase; Provisional; Region: PRK11204 871585000603 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 871585000604 DXD motif; other site 871585000605 PgaD-like protein; Region: PgaD; pfam13994 871585000606 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 871585000607 substrate binding site [chemical binding]; other site 871585000608 oxyanion hole (OAH) forming residues; other site 871585000609 trimer interface [polypeptide binding]; other site 871585000610 Nicotinamide mononucleotide transporter; Region: NMN_transporter; pfam04973 871585000611 Transcriptional regulator [Transcription]; Region: IclR; COG1414 871585000612 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 871585000613 Bacterial transcriptional regulator; Region: IclR; pfam01614 871585000614 Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528 871585000615 [2Fe-2S] cluster binding site [ion binding]; other site 871585000616 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 871585000617 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 871585000618 [2Fe-2S] cluster binding site [ion binding]; other site 871585000619 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 871585000620 hydrophobic ligand binding site; other site 871585000621 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 871585000622 classical (c) SDRs; Region: SDR_c; cd05233 871585000623 NAD(P) binding site [chemical binding]; other site 871585000624 active site 871585000625 2,3-dihydroxybiphenyl 1,2-dioxygenase; Region: 23dbph12diox; TIGR03213 871585000626 C-terminal domain of Burkholderia sp. NF100 MhqB and similar proteins; MhqB is a type I extradiol dioxygenase involved in the catabolism of methylhydroquinone, an intermediate in the degradation of fenitrothion; Region: MhqB_like_C; cd08360 871585000627 putative active site [active] 871585000628 putative metal binding site [ion binding]; other site 871585000629 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 871585000630 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 871585000631 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 871585000632 D-galactonate transporter; Region: 2A0114; TIGR00893 871585000633 putative substrate translocation pore; other site 871585000634 Cupin domain; Region: Cupin_2; pfam07883 871585000635 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 871585000636 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 871585000637 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 871585000638 short chain dehydrogenase; Provisional; Region: PRK07062 871585000639 putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344 871585000640 putative NAD(P) binding site [chemical binding]; other site 871585000641 putative active site [active] 871585000642 L-aspartate dehydrogenase; Provisional; Region: PRK13303 871585000643 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 871585000644 Domain of unknown function DUF108; Region: DUF108; pfam01958 871585000645 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 871585000646 Uncharacterized Candidatus pelagibacter aldehyde dehydrogenase, DhaS-like; Region: ALDH_DhaS; cd07114 871585000647 NAD(P) binding site [chemical binding]; other site 871585000648 catalytic residues [active] 871585000649 hypothetical protein; Provisional; Region: PRK07064 871585000650 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 871585000651 PYR/PP interface [polypeptide binding]; other site 871585000652 dimer interface [polypeptide binding]; other site 871585000653 TPP binding site [chemical binding]; other site 871585000654 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 871585000655 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 871585000656 TPP-binding site [chemical binding]; other site 871585000657 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 871585000658 metabolite-proton symporter; Region: 2A0106; TIGR00883 871585000659 putative substrate translocation pore; other site 871585000660 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 871585000661 active site 871585000662 catalytic residues [active] 871585000663 metal binding site [ion binding]; metal-binding site 871585000664 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 871585000665 glutaminase; Provisional; Region: PRK00971 871585000666 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 871585000667 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 871585000668 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 871585000669 putative substrate translocation pore; other site 871585000670 Major Facilitator Superfamily; Region: MFS_1; pfam07690 871585000671 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 871585000672 active site 871585000673 catalytic residues [active] 871585000674 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 871585000675 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 871585000676 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 871585000677 dimerization interface [polypeptide binding]; other site 871585000678 substrate binding pocket [chemical binding]; other site 871585000679 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 871585000680 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 871585000681 NAD(P) binding site [chemical binding]; other site 871585000682 active site 871585000683 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 871585000684 D-galactonate transporter; Region: 2A0114; TIGR00893 871585000685 putative substrate translocation pore; other site 871585000686 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 871585000687 TPP-binding site [chemical binding]; other site 871585000688 dimer interface [polypeptide binding]; other site 871585000689 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 871585000690 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 871585000691 PYR/PP interface [polypeptide binding]; other site 871585000692 dimer interface [polypeptide binding]; other site 871585000693 TPP binding site [chemical binding]; other site 871585000694 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 871585000695 potential frameshift: common BLAST hit: gi|215484308|ref|YP_002326537.1| B12-dependent methionine synthase 871585000696 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 871585000697 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 871585000698 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 871585000699 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 871585000700 substrate binding pocket [chemical binding]; other site 871585000701 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 871585000702 Predicted cobalamin binding protein [General function prediction only]; Region: COG5012 871585000703 B12 binding site [chemical binding]; other site 871585000704 cobalt ligand [ion binding]; other site 871585000705 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 871585000706 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 871585000707 D-Serine dehydratase is a pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of L- or D-serine to pyruvate and ammonia. D-serine dehydratase serves as a detoxifying enzyme in most E. coli strains where D-serine is a competitive...; Region: D-Ser-dehyd; cd06447 871585000708 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 871585000709 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 871585000710 catalytic residue [active] 871585000711 Uncharacterized conserved protein [Function unknown]; Region: COG1262 871585000712 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 871585000713 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 871585000714 Sulfatase; Region: Sulfatase; pfam00884 871585000715 Rhomboid family; Region: Rhomboid; cl11446 871585000716 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 871585000717 IscR-regulated protein YhgI; Region: YhgI_GntY; TIGR03341 871585000718 Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694 871585000719 outer membrane receptor FepA; Provisional; Region: PRK13524 871585000720 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 871585000721 N-terminal plug; other site 871585000722 ligand-binding site [chemical binding]; other site 871585000723 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 871585000724 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 871585000725 nucleophilic elbow; other site 871585000726 catalytic triad; other site 871585000727 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378 871585000728 active site clefts [active] 871585000729 zinc binding site [ion binding]; other site 871585000730 dimer interface [polypeptide binding]; other site 871585000731 Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822 871585000732 active site 871585000733 catalytic triad [active] 871585000734 oxyanion hole [active] 871585000735 switch loop; other site 871585000736 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG4181 871585000737 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 871585000738 Walker A/P-loop; other site 871585000739 ATP binding site [chemical binding]; other site 871585000740 Q-loop/lid; other site 871585000741 ABC transporter signature motif; other site 871585000742 Walker B; other site 871585000743 D-loop; other site 871585000744 H-loop/switch region; other site 871585000745 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127 871585000746 FtsX-like permease family; Region: FtsX; pfam02687 871585000747 Rhomboid family; Region: Rhomboid; pfam01694 871585000748 monofunctional biosynthetic peptidoglycan transglycosylase; Provisional; Region: mtgA; PRK00056 871585000749 Transglycosylase; Region: Transgly; cl17702 871585000750 polyphosphate kinase; Provisional; Region: PRK05443 871585000751 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 871585000752 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 871585000753 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 871585000754 putative active site [active] 871585000755 catalytic site [active] 871585000756 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 871585000757 putative active site [active] 871585000758 putative domain interface [polypeptide binding]; other site 871585000759 catalytic site [active] 871585000760 Sporulation related domain; Region: SPOR; pfam05036 871585000761 DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151 871585000762 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 871585000763 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 871585000764 dimerization interface [polypeptide binding]; other site 871585000765 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 871585000766 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 871585000767 NADH:flavorubredoxin oxidoreductase; Provisional; Region: PRK04965 871585000768 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 871585000769 Rubredoxin [Energy production and conversion]; Region: COG1773 871585000770 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 871585000771 iron binding site [ion binding]; other site 871585000772 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 871585000773 putative hydrophobic ligand binding site [chemical binding]; other site 871585000774 Uncharacterized protein family (UPF0227); Region: UPF0227; cl14886 871585000775 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 871585000776 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 871585000777 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 871585000778 dimer interface [polypeptide binding]; other site 871585000779 putative anticodon binding site; other site 871585000780 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 871585000781 motif 1; other site 871585000782 active site 871585000783 motif 2; other site 871585000784 motif 3; other site 871585000785 Capsule assembly protein Wzi; Region: Caps_assemb_Wzi; pfam14052 871585000786 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 871585000787 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 871585000788 Active Sites [active] 871585000789 sulfate adenylyltransferase subunit 1; Provisional; Region: cysN; PRK05124 871585000790 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 871585000791 CysD dimerization site [polypeptide binding]; other site 871585000792 G1 box; other site 871585000793 putative GEF interaction site [polypeptide binding]; other site 871585000794 GTP/Mg2+ binding site [chemical binding]; other site 871585000795 Switch I region; other site 871585000796 G2 box; other site 871585000797 G3 box; other site 871585000798 Switch II region; other site 871585000799 G4 box; other site 871585000800 G5 box; other site 871585000801 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 871585000802 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 871585000803 Uncharacterized protein conserved in bacteria (DUF2239); Region: DUF2239; pfam09998 871585000804 H+/citrate symporter [Energy production and conversion]; Region: CitM; COG2851 871585000805 Citrate transporter; Region: CitMHS; pfam03600 871585000806 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 871585000807 Domain of unknown function DUF21; Region: DUF21; pfam01595 871585000808 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 871585000809 Transporter associated domain; Region: CorC_HlyC; smart01091 871585000810 Transcriptional regulator [Transcription]; Region: LysR; COG0583 871585000811 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 871585000812 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 871585000813 substrate binding pocket [chemical binding]; other site 871585000814 dimerization interface [polypeptide binding]; other site 871585000815 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 871585000816 tetramer interface [polypeptide binding]; other site 871585000817 active site 871585000818 Mg2+/Mn2+ binding site [ion binding]; other site 871585000819 isocitrate lyase; Region: PLN02892 871585000820 NlpE N-terminal domain; Region: NlpE; pfam04170 871585000821 UreD urease accessory protein; Region: UreD; pfam01774 871585000822 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 871585000823 alpha-gamma subunit interface [polypeptide binding]; other site 871585000824 beta-gamma subunit interface [polypeptide binding]; other site 871585000825 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 871585000826 gamma-beta subunit interface [polypeptide binding]; other site 871585000827 alpha-beta subunit interface [polypeptide binding]; other site 871585000828 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 871585000829 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 871585000830 Coenzyme A binding pocket [chemical binding]; other site 871585000831 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 871585000832 urease subunit alpha; Reviewed; Region: ureC; PRK13207 871585000833 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 871585000834 subunit interactions [polypeptide binding]; other site 871585000835 active site 871585000836 flap region; other site 871585000837 urease accessory protein UreE; Provisional; Region: ureE; PRK13261 871585000838 UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571 871585000839 dimer interface [polypeptide binding]; other site 871585000840 catalytic residues [active] 871585000841 Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830 871585000842 UreF; Region: UreF; pfam01730 871585000843 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 871585000844 G1 box; other site 871585000845 GTP/Mg2+ binding site [chemical binding]; other site 871585000846 G2 box; other site 871585000847 Switch I region; other site 871585000848 G3 box; other site 871585000849 Switch II region; other site 871585000850 G4 box; other site 871585000851 G5 box; other site 871585000852 HupE / UreJ protein; Region: HupE_UreJ; pfam04955 871585000853 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 871585000854 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 871585000855 S-adenosylmethionine binding site [chemical binding]; other site 871585000856 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 871585000857 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 871585000858 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 871585000859 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399 871585000860 adenylate kinase; Reviewed; Region: adk; PRK00279 871585000861 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 871585000862 AMP-binding site [chemical binding]; other site 871585000863 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 871585000864 endonuclease III; Provisional; Region: PRK10702 871585000865 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 871585000866 minor groove reading motif; other site 871585000867 helix-hairpin-helix signature motif; other site 871585000868 substrate binding pocket [chemical binding]; other site 871585000869 active site 871585000870 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 871585000871 ferredoxin; Provisional; Region: PRK08764 871585000872 Putative Fe-S cluster; Region: FeS; cl17515 871585000873 4Fe-4S binding domain; Region: Fer4; pfam00037 871585000874 glutamate dehydrogenase; Provisional; Region: PRK09414 871585000875 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 871585000876 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 871585000877 NAD(P) binding site [chemical binding]; other site 871585000878 META domain; Region: META; pfam03724 871585000879 META domain; Region: META; pfam03724 871585000880 Domain of unknown function (DUF4377); Region: DUF4377; pfam14302 871585000881 The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363 871585000882 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 871585000883 putative active site [active] 871585000884 metal binding site [ion binding]; metal-binding site 871585000885 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 871585000886 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 871585000887 Found in ATP-dependent protease La (LON); Region: LON; smart00464 871585000888 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 871585000889 Walker A motif; other site 871585000890 ATP binding site [chemical binding]; other site 871585000891 Walker B motif; other site 871585000892 arginine finger; other site 871585000893 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 871585000894 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 871585000895 serine hydroxymethyltransferase; Reviewed; Region: PRK13034 871585000896 Cell division protein ZapA; Region: ZapA; pfam05164 871585000897 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 871585000898 Uncharacterized protein family (UPF0149); Region: UPF0149; pfam03695 871585000899 Aminopeptidase P, N-terminal domain; Region: AMP_N; pfam05195 871585000900 proline aminopeptidase P II; Provisional; Region: PRK10879 871585000901 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 871585000902 active site 871585000903 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 871585000904 Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988 871585000905 Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988 871585000906 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 871585000907 Cd(II)/Pb(II)-responsive transcriptional regulator; Region: CadR-PbrR; TIGR02047 871585000908 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 871585000909 DNA binding residues [nucleotide binding] 871585000910 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 871585000911 Lysine efflux permease [General function prediction only]; Region: COG1279 871585000912 chromosome replication initiation inhibitor protein; Validated; Region: PRK03635 871585000913 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 871585000914 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 871585000915 dimerization interface [polypeptide binding]; other site 871585000916 Menaquinone biosynthesis; Region: VitK2_biosynth; cl17475 871585000917 Predicted methyltransferases [General function prediction only]; Region: COG0313 871585000918 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 871585000919 putative SAM binding site [chemical binding]; other site 871585000920 putative homodimer interface [polypeptide binding]; other site 871585000921 hypothetical protein; Provisional; Region: PRK14674 871585000922 Predicted periplasmic or secreted lipoprotein [General function prediction only]; Region: OsmY; COG2823 871585000923 BON domain; Region: BON; pfam04972 871585000924 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 871585000925 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 871585000926 NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296 871585000927 NADH pyrophosphatase; Reviewed; Region: nudC; PRK00241 871585000928 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 871585000929 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 871585000930 putative NADH binding site [chemical binding]; other site 871585000931 putative active site [active] 871585000932 nudix motif; other site 871585000933 putative metal binding site [ion binding]; other site 871585000934 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 871585000935 RNA/DNA hybrid binding site [nucleotide binding]; other site 871585000936 active site 871585000937 DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406 871585000938 DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131 871585000939 active site 871585000940 catalytic site [active] 871585000941 substrate binding site [chemical binding]; other site 871585000942 membrane-bound lytic murein transglycosylase D; Provisional; Region: mltD; PRK10783 871585000943 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 871585000944 N-acetyl-D-glucosamine binding site [chemical binding]; other site 871585000945 catalytic residue [active] 871585000946 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 871585000947 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 871585000948 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 871585000949 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 871585000950 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 871585000951 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 871585000952 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 871585000953 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 871585000954 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 871585000955 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 871585000956 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 871585000957 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 871585000958 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497 871585000959 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 871585000960 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4174 871585000961 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 871585000962 dimer interface [polypeptide binding]; other site 871585000963 conserved gate region; other site 871585000964 putative PBP binding loops; other site 871585000965 ABC-ATPase subunit interface; other site 871585000966 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4239 871585000967 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 871585000968 dimer interface [polypeptide binding]; other site 871585000969 conserved gate region; other site 871585000970 putative PBP binding loops; other site 871585000971 ABC-ATPase subunit interface; other site 871585000972 ABC-type uncharacterized transport system, duplicated ATPase component [General function prediction only]; Region: COG4172 871585000973 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 871585000974 Walker A/P-loop; other site 871585000975 ATP binding site [chemical binding]; other site 871585000976 Q-loop/lid; other site 871585000977 ABC transporter signature motif; other site 871585000978 Walker B; other site 871585000979 D-loop; other site 871585000980 H-loop/switch region; other site 871585000981 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 871585000982 Walker A/P-loop; other site 871585000983 ATP binding site [chemical binding]; other site 871585000984 Q-loop/lid; other site 871585000985 ABC transporter signature motif; other site 871585000986 Walker B; other site 871585000987 D-loop; other site 871585000988 H-loop/switch region; other site 871585000989 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 871585000990 Old yellow enzyme (OYE)-related FMN binding domain, group 2. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_2_FMN; cd04733 871585000991 putative active site [active] 871585000992 putative FMN binding site [chemical binding]; other site 871585000993 putative substrate binding site [chemical binding]; other site 871585000994 putative catalytic residue [active] 871585000995 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 871585000996 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 871585000997 N-terminal plug; other site 871585000998 ligand-binding site [chemical binding]; other site 871585000999 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 871585001000 DEDDh 3'-5' exonuclease domain of RNase T; Region: RNaseT; cd06134 871585001001 dimer interface [polypeptide binding]; other site 871585001002 catalytic site [active] 871585001003 putative active site [active] 871585001004 putative substrate binding site [chemical binding]; other site 871585001005 Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294 871585001006 active site 871585001007 substrate binding pocket [chemical binding]; other site 871585001008 dimer interface [polypeptide binding]; other site 871585001009 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 871585001010 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 871585001011 metal binding site [ion binding]; metal-binding site 871585001012 active site 871585001013 I-site; other site 871585001014 argininosuccinate synthase; Provisional; Region: PRK13820 871585001015 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 871585001016 ANP binding site [chemical binding]; other site 871585001017 Substrate Binding Site II [chemical binding]; other site 871585001018 Substrate Binding Site I [chemical binding]; other site 871585001019 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 871585001020 2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930 871585001021 active site 871585001022 FMN binding site [chemical binding]; other site 871585001023 2,4-decadienoyl-CoA binding site; other site 871585001024 catalytic residue [active] 871585001025 4Fe-4S cluster binding site [ion binding]; other site 871585001026 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 871585001027 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 871585001028 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 871585001029 Bacterial protein of unknown function (DUF898); Region: DUF898; pfam05987 871585001030 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 871585001031 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 871585001032 Uncharacterized protein conserved in bacteria [Function unknown]; Region: VgrG; COG3501 871585001033 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 871585001034 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 871585001035 Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296 871585001036 Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; pfam10106 871585001037 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 871585001038 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 871585001039 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 871585001040 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 871585001041 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 871585001042 Cache domain; Region: Cache_1; pfam02743 871585001043 Transcriptional regulators [Transcription]; Region: FadR; COG2186 871585001044 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 871585001045 DNA-binding site [nucleotide binding]; DNA binding site 871585001046 FCD domain; Region: FCD; pfam07729 871585001047 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 871585001048 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 871585001049 gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK13473 871585001050 Escherichia coli NAD+-dependent gamma-aminobutyraldehyde dehydrogenase YdcW-like; Region: ALDH_ABALDH-YdcW; cd07092 871585001051 tetrameric interface [polypeptide binding]; other site 871585001052 NAD binding site [chemical binding]; other site 871585001053 catalytic residues [active] 871585001054 substrate binding site [chemical binding]; other site 871585001055 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 871585001056 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 871585001057 AsnC family; Region: AsnC_trans_reg; pfam01037 871585001058 bifunctional succinylornithine transaminase/acetylornithine transaminase; Provisional; Region: PRK12381 871585001059 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 871585001060 inhibitor-cofactor binding pocket; inhibition site 871585001061 pyridoxal 5'-phosphate binding site [chemical binding]; other site 871585001062 catalytic residue [active] 871585001063 Arginine/ornithine N-succinyltransferase beta subunit [Amino acid transport and metabolism]; Region: AstA; COG3138 871585001064 Arginine N-succinyltransferase beta subunit; Region: AstA; cl11440 871585001065 D-alanine/D-serine/glycine permease; Provisional; Region: PRK11049 871585001066 Domain of unknown function (DUF4265); Region: DUF4265; pfam14085 871585001067 aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381 871585001068 Coniferyl aldehyde dehydrogenase-like; Region: ALDH_CALDH_CalB; cd07133 871585001069 NAD(P) binding site [chemical binding]; other site 871585001070 catalytic residues [active] 871585001071 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 871585001072 HTH domain; Region: HTH_11; cl17392 871585001073 Helix-turn-helix domain; Region: HTH_18; pfam12833 871585001074 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 871585001075 EamA-like transporter family; Region: EamA; pfam00892 871585001076 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 871585001077 galactarate dehydratase; Region: galactar-dH20; TIGR03248 871585001078 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 871585001079 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 871585001080 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 871585001081 D-galactonate transporter; Region: 2A0114; TIGR00893 871585001082 putative substrate translocation pore; other site 871585001083 glucarate dehydratase; Region: glucar-dehydr; TIGR03247 871585001084 D-Glucarate dehydratase (GlucD) catalyzes the dehydration of both D-glucarate and L-idarate to form 5-keto-4-deoxy-D-glucarate (5-KDG) , the initial reaction of the catabolic pathway for (D)-glucarate. GlucD belongs to the enolase superfamily of enzymes; Region: D-glucarate_dehydratase; cd03323 871585001085 active site 871585001086 tetramer interface [polypeptide binding]; other site 871585001087 5-dehydro-4-deoxyglucarate dehydratase, also called 5-keto-4-deoxy-glucarate dehydratase (KDGDH); Region: KDGDH; cd00951 871585001088 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 871585001089 putative active site [active] 871585001090 catalytic residue [active] 871585001091 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 871585001092 Alpha-Ketoglutaric Semialdehyde Dehydrogenase; Region: ALDH_KGSADH; cd07129 871585001093 dimer interface [polypeptide binding]; other site 871585001094 NADP binding site [chemical binding]; other site 871585001095 catalytic residues [active] 871585001096 Transcriptional regulators [Transcription]; Region: FadR; COG2186 871585001097 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 871585001098 DNA-binding site [nucleotide binding]; DNA binding site 871585001099 FCD domain; Region: FCD; pfam07729 871585001100 Tannase and feruloyl esterase; Region: Tannase; pfam07519 871585001101 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 871585001102 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 871585001103 CoenzymeA binding site [chemical binding]; other site 871585001104 subunit interaction site [polypeptide binding]; other site 871585001105 PHB binding site; other site 871585001106 Protein of unknown function (DUF3237); Region: DUF3237; pfam11578 871585001107 outer membrane porin, OprD family; Region: OprD; pfam03573 871585001108 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 871585001109 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 871585001110 active site 871585001111 feruloyl-CoA synthase; Reviewed; Region: PRK08180 871585001112 Feruloyl-CoA synthetase (FCS); Region: FCS; cd05921 871585001113 acyl-activating enzyme (AAE) consensus motif; other site 871585001114 putative AMP binding site [chemical binding]; other site 871585001115 putative active site [active] 871585001116 putative CoA binding site [chemical binding]; other site 871585001117 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 871585001118 Salicylaldehyde dehydrogenase, DoxF-like; Region: ALDH_SaliADH; cd07105 871585001119 NAD(P) binding site [chemical binding]; other site 871585001120 catalytic residues [active] 871585001121 p-hydroxycinnamoyl CoA hydratase/lyase; Validated; Region: PRK09120 871585001122 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 871585001123 substrate binding site [chemical binding]; other site 871585001124 oxyanion hole (OAH) forming residues; other site 871585001125 trimer interface [polypeptide binding]; other site 871585001126 putative 3-hydroxyphenylpropionic transporter MhpT; Provisional; Region: PRK11551 871585001127 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 871585001128 putative substrate translocation pore; other site 871585001129 MarR family; Region: MarR_2; pfam12802 871585001130 Transcriptional regulators [Transcription]; Region: GntR; COG1802 871585001131 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 871585001132 DNA-binding site [nucleotide binding]; DNA binding site 871585001133 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 871585001134 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 871585001135 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 871585001136 FMN-binding pocket [chemical binding]; other site 871585001137 flavin binding motif; other site 871585001138 phosphate binding motif [ion binding]; other site 871585001139 beta-alpha-beta structure motif; other site 871585001140 NAD binding pocket [chemical binding]; other site 871585001141 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 871585001142 catalytic loop [active] 871585001143 iron binding site [ion binding]; other site 871585001144 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 871585001145 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 871585001146 iron-sulfur cluster [ion binding]; other site 871585001147 [2Fe-2S] cluster binding site [ion binding]; other site 871585001148 C-terminal catalytic domain of the oxygenase alpha subunit of dicamba O-demethylase and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_DMO-like; cd08878 871585001149 alpha subunit interface [polypeptide binding]; other site 871585001150 active site 871585001151 substrate binding site [chemical binding]; other site 871585001152 Fe binding site [ion binding]; other site 871585001153 outer membrane porin, OprD family; Region: OprD; pfam03573 871585001154 Uncharacterized conserved protein [Function unknown]; Region: COG1262 871585001155 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 871585001156 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 871585001157 Sulfatase; Region: Sulfatase; pfam00884 871585001158 benzoate transport; Region: 2A0115; TIGR00895 871585001159 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 871585001160 putative substrate translocation pore; other site 871585001161 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 871585001162 outer membrane porin, OprD family; Region: OprD; pfam03573 871585001163 YcaO domain protein; Region: TIGR03549 871585001164 OsmC-like protein; Region: OsmC; pfam02566 871585001165 YcaO-like family; Region: YcaO; pfam02624 871585001166 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 871585001167 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 871585001168 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 871585001169 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 871585001170 classical (c) SDRs; Region: SDR_c; cd05233 871585001171 short chain dehydrogenase; Provisional; Region: PRK05650 871585001172 NAD(P) binding site [chemical binding]; other site 871585001173 active site 871585001174 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 871585001175 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 871585001176 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 871585001177 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 871585001178 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 871585001179 L(+)-tartrate dehydratase subunit beta; Validated; Region: PRK08228 871585001180 tartrate dehydratase subunit alpha; Validated; Region: PRK08230 871585001181 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 871585001182 D-galactonate transporter; Region: 2A0114; TIGR00893 871585001183 putative substrate translocation pore; other site 871585001184 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 871585001185 transcriptional activator TtdR; Provisional; Region: PRK09801 871585001186 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_9; cd08479 871585001187 putative effector binding pocket; other site 871585001188 putative dimerization interface [polypeptide binding]; other site 871585001189 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 871585001190 Leucine carboxyl methyltransferase; Region: LCM; pfam04072 871585001191 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 871585001192 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 871585001193 classical (c) SDRs; Region: SDR_c; cd05233 871585001194 short chain dehydrogenase; Provisional; Region: PRK05650 871585001195 NAD(P) binding site [chemical binding]; other site 871585001196 active site 871585001197 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687 871585001198 Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118 871585001199 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 871585001200 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 871585001201 Pirin-related protein [General function prediction only]; Region: COG1741 871585001202 Pirin; Region: Pirin; pfam02678 871585001203 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 871585001204 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 871585001205 Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320 871585001206 active site 871585001207 purine riboside binding site [chemical binding]; other site 871585001208 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 871585001209 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 871585001210 RNA/DNA hybrid binding site [nucleotide binding]; other site 871585001211 active site 871585001212 carbon storage regulator; Provisional; Region: PRK01712 871585001213 aspartate kinase; Reviewed; Region: PRK06635 871585001214 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 871585001215 putative nucleotide binding site [chemical binding]; other site 871585001216 putative catalytic residues [active] 871585001217 putative Mg ion binding site [ion binding]; other site 871585001218 putative aspartate binding site [chemical binding]; other site 871585001219 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 871585001220 putative allosteric regulatory site; other site 871585001221 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 871585001222 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 871585001223 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 871585001224 motif 1; other site 871585001225 active site 871585001226 motif 2; other site 871585001227 motif 3; other site 871585001228 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 871585001229 DHHA1 domain; Region: DHHA1; pfam02272 871585001230 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 871585001231 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 871585001232 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 871585001233 ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: PRK12421 871585001234 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 871585001235 dimer interface [polypeptide binding]; other site 871585001236 motif 1; other site 871585001237 active site 871585001238 motif 2; other site 871585001239 motif 3; other site 871585001240 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 871585001241 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 871585001242 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 871585001243 Peptidase family M48; Region: Peptidase_M48; pfam01435 871585001244 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 871585001245 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 871585001246 active site 871585001247 catalytic tetrad [active] 871585001248 DNA-binding transcriptional dual regulator Crp; Provisional; Region: PRK11753 871585001249 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 871585001250 ligand binding site [chemical binding]; other site 871585001251 flexible hinge region; other site 871585001252 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 871585001253 putative switch regulator; other site 871585001254 non-specific DNA interactions [nucleotide binding]; other site 871585001255 DNA binding site [nucleotide binding] 871585001256 sequence specific DNA binding site [nucleotide binding]; other site 871585001257 putative cAMP binding site [chemical binding]; other site 871585001258 OsmC-like protein; Region: OsmC; cl00767 871585001259 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 871585001260 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 871585001261 Coenzyme A binding pocket [chemical binding]; other site 871585001262 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 871585001263 Peptidase family M23; Region: Peptidase_M23; pfam01551 871585001264 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 871585001265 Clp amino terminal domain; Region: Clp_N; pfam02861 871585001266 Clp amino terminal domain; Region: Clp_N; pfam02861 871585001267 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 871585001268 Walker A motif; other site 871585001269 ATP binding site [chemical binding]; other site 871585001270 Walker B motif; other site 871585001271 arginine finger; other site 871585001272 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 871585001273 Walker A motif; other site 871585001274 ATP binding site [chemical binding]; other site 871585001275 Walker B motif; other site 871585001276 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 871585001277 Competence-damaged protein; Region: CinA; pfam02464 871585001278 23S rRNA m(2)G2445 methyltransferase; Provisional; Region: rlmL; PRK11783 871585001279 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 871585001280 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 871585001281 DNA methylase; Region: N6_N4_Mtase; cl17433 871585001282 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 871585001283 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 871585001284 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 871585001285 dihydroorotase; Validated; Region: pyrC; PRK09357 871585001286 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 871585001287 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 871585001288 active site 871585001289 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 871585001290 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 871585001291 ligand binding site [chemical binding]; other site 871585001292 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 871585001293 Domain of unknown function (DUF2520); Region: DUF2520; pfam10728 871585001294 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 871585001295 GST_N family, unknown subfamily 2; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_2; cd03047 871585001296 putative C-terminal domain interface [polypeptide binding]; other site 871585001297 putative GSH binding site (G-site) [chemical binding]; other site 871585001298 putative dimer interface [polypeptide binding]; other site 871585001299 C-terminal, alpha helical domain of an unknown subfamily 2 of Glutathione S-transferases; Region: GST_C_2; cd03180 871585001300 putative N-terminal domain interface [polypeptide binding]; other site 871585001301 putative dimer interface [polypeptide binding]; other site 871585001302 putative substrate binding pocket (H-site) [chemical binding]; other site 871585001303 tRNA (guanine-N(7)-)-methyltransferase; Reviewed; Region: trmB; PRK00121 871585001304 Predicted extracellular nuclease [General function prediction only]; Region: COG2374 871585001305 YhcR_OBF_like: A subfamily of OB-fold domains similar to the OB folds of Bacillus subtilis YhcR. YhcR is a sugar-nonspecific nuclease, which is active in the presence of Ca2+ and Mn2+. It cleaves RNA endonucleolytically, producing 3'-monophosphate...; Region: YhcR_OBF_like; cd04486 871585001306 generic binding surface II; other site 871585001307 generic binding surface I; other site 871585001308 Mycoplasma pulmonis MnuA nuclease-like; Region: MnuA_DNase1-like; cd10283 871585001309 putative active site [active] 871585001310 putative catalytic site [active] 871585001311 putative Mg binding site IVb [ion binding]; other site 871585001312 putative phosphate binding site [ion binding]; other site 871585001313 putative DNA binding site [nucleotide binding]; other site 871585001314 putative Mg binding site IVa [ion binding]; other site 871585001315 glutathionine S-transferase; Provisional; Region: PRK10542 871585001316 GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057 871585001317 C-terminal domain interface [polypeptide binding]; other site 871585001318 GSH binding site (G-site) [chemical binding]; other site 871585001319 dimer interface [polypeptide binding]; other site 871585001320 C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188 871585001321 dimer interface [polypeptide binding]; other site 871585001322 N-terminal domain interface [polypeptide binding]; other site 871585001323 substrate binding pocket (H-site) [chemical binding]; other site 871585001324 alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317 871585001325 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974 871585001326 catalytic residue [active] 871585001327 TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026 871585001328 catalytic residues [active] 871585001329 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 871585001330 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 871585001331 Protein of unknown function (DUF1653); Region: DUF1653; pfam07866 871585001332 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 871585001333 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 871585001334 S-adenosylmethionine binding site [chemical binding]; other site 871585001335 KTSC domain; Region: KTSC; pfam13619 871585001336 peroxiredoxin; Region: AhpC; TIGR03137 871585001337 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 871585001338 dimer interface [polypeptide binding]; other site 871585001339 decamer (pentamer of dimers) interface [polypeptide binding]; other site 871585001340 catalytic triad [active] 871585001341 peroxidatic and resolving cysteines [active] 871585001342 ATP-dependent helicase HrpA; Region: DEAH_box_HrpA; TIGR01967 871585001343 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 871585001344 ATP binding site [chemical binding]; other site 871585001345 putative Mg++ binding site [ion binding]; other site 871585001346 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 871585001347 nucleotide binding region [chemical binding]; other site 871585001348 ATP-binding site [chemical binding]; other site 871585001349 Helicase associated domain (HA2); Region: HA2; pfam04408 871585001350 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 871585001351 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 871585001352 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK07515 871585001353 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 871585001354 dimer interface [polypeptide binding]; other site 871585001355 active site 871585001356 CoA binding pocket [chemical binding]; other site 871585001357 outer membrane porin, OprD family; Region: OprD; pfam03573 871585001358 benzoate transport; Region: 2A0115; TIGR00895 871585001359 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 871585001360 putative substrate translocation pore; other site 871585001361 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 871585001362 putative substrate translocation pore; other site 871585001363 benzoate transporter; Region: benE; TIGR00843 871585001364 Benzoate membrane transport protein; Region: BenE; pfam03594 871585001365 1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate dehydrogenase; Provisional; Region: benD; PRK12823 871585001366 1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate dehydrogenase (DHB DH)-like, classical (c) SDR; Region: DHB_DH-like_SDR_c; cd08937 871585001367 putative NAD(P) binding site [chemical binding]; other site 871585001368 active site 871585001369 anthranilate dioxygenase reductase; Provisional; Region: antC; PRK11872 871585001370 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 871585001371 catalytic loop [active] 871585001372 iron binding site [ion binding]; other site 871585001373 Benzoate dioxygenase reductase (BenDO) FAD/NAD binding domain. Oxygenases oxidize hydrocarbons using dioxygen as the oxidant. As a Class I bacterial dioxygenases, benzoate dioxygenase like proteins combine an [2Fe-2S] cluster containing N-terminal...; Region: BenDO_FAD_NAD; cd06209 871585001374 FAD binding pocket [chemical binding]; other site 871585001375 FAD binding motif [chemical binding]; other site 871585001376 phosphate binding motif [ion binding]; other site 871585001377 beta-alpha-beta structure motif; other site 871585001378 NAD binding pocket [chemical binding]; other site 871585001379 Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667 871585001380 inter-subunit interface; other site 871585001381 benzoate 1,2-dioxygenase, large subunit; Region: benzo_1_2_benA; TIGR03229 871585001382 Rieske non-heme iron oxygenase (RO) family, 2-Halobenzoate 1,2-dioxygenase (HBDO) subfamily, N-terminal Rieske domain of the oxygenase alpha subunit; ROs comprise a large class of aromatic ring-hydroxylating dioxygenases that enable microorganisms to...; Region: Rieske_RO_Alpha_HBDO; cd03542 871585001383 C-terminal catalytic domain of the oxygenase alpha subunit of Pseudomonas resinovorans strain CA10 anthranilate 1,2-dioxygenase and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_AntDO-like; cd08879 871585001384 putative alpha subunit interface [polypeptide binding]; other site 871585001385 putative active site [active] 871585001386 putative substrate binding site [chemical binding]; other site 871585001387 Fe binding site [ion binding]; other site 871585001388 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 871585001389 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 871585001390 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 871585001391 dimerization interface [polypeptide binding]; other site 871585001392 Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; cl01768 871585001393 CDP-6-deoxy-delta-3,4-glucoseen reductase; Validated; Region: PRK07609 871585001394 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 871585001395 catalytic loop [active] 871585001396 iron binding site [ion binding]; other site 871585001397 Phenol 2-monooxygenase (phenol hydroxylase) is a flavoprotein monooxygenase, able to use molecular oxygen as a substrate in the microbial degredation of phenol. This protein is encoded by a single gene and uses a tightly bound FAD cofactor in the NAD(P)H...; Region: phenol_2-monooxygenase_like; cd06211 871585001398 FAD binding pocket [chemical binding]; other site 871585001399 FAD binding motif [chemical binding]; other site 871585001400 phosphate binding motif [ion binding]; other site 871585001401 beta-alpha-beta structure motif; other site 871585001402 NAD binding pocket [chemical binding]; other site 871585001403 Phenol hydroxylase conserved region; Region: Phenol_monoox; pfam04663 871585001404 Aromatic and Alkene Monooxygenase Hydroxylase, subunit A, ferritin-like diiron-binding domain; Region: AAMH_A; cd01057 871585001405 dimerization interface [polypeptide binding]; other site 871585001406 putative path to active site cavity [active] 871585001407 diiron center [ion binding]; other site 871585001408 MmoB/DmpM family; Region: MmoB_DmpM; pfam02406 871585001409 Aromatic and Alkene Monooxygenase Hydroxylase, subunit B, ferritin-like diiron-binding domain; Region: AAMH_B; cd01058 871585001410 dimerization interface [polypeptide binding]; other site 871585001411 Phenol hydroxylase subunit; Region: Phenol_hyd_sub; pfam06099 871585001412 Activator of aromatic catabolism; Region: XylR_N; pfam06505 871585001413 V4R domain; Region: V4R; pfam02830 871585001414 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 871585001415 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 871585001416 Walker A motif; other site 871585001417 ATP binding site [chemical binding]; other site 871585001418 Walker B motif; other site 871585001419 arginine finger; other site 871585001420 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 871585001421 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 871585001422 metal-binding site [ion binding] 871585001423 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 871585001424 metal-binding site [ion binding] 871585001425 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 871585001426 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 871585001427 metal-binding site [ion binding] 871585001428 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 871585001429 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 871585001430 motif II; other site 871585001431 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 871585001432 DNA binding residues [nucleotide binding] 871585001433 Glutathione-dependent formaldehyde-activating enzyme; Region: GFA; pfam04828 871585001434 Cysteine-rich 4 helical bundle widely conserved in bacteria; Region: DUF326; cd08026 871585001435 dimerization interface [polypeptide binding]; other site 871585001436 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 871585001437 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 871585001438 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 871585001439 generic binding surface II; other site 871585001440 generic binding surface I; other site 871585001441 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 871585001442 Predicted transcriptional regulator [Transcription]; Region: COG2932 871585001443 non-specific DNA binding site [nucleotide binding]; other site 871585001444 salt bridge; other site 871585001445 sequence-specific DNA binding site [nucleotide binding]; other site 871585001446 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 871585001447 Catalytic site [active] 871585001448 Glycosyl hydrolase 108; Region: Glyco_hydro_108; pfam05838 871585001449 Predicted Peptidoglycan domain; Region: PG_binding_3; pfam09374 871585001450 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 871585001451 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 871585001452 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 871585001453 putative acyl-acceptor binding pocket; other site 871585001454 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 871585001455 DNA-binding site [nucleotide binding]; DNA binding site 871585001456 RNA-binding motif; other site 871585001457 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 871585001458 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 871585001459 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 871585001460 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 871585001461 putative DNA binding site [nucleotide binding]; other site 871585001462 putative Zn2+ binding site [ion binding]; other site 871585001463 AsnC family; Region: AsnC_trans_reg; pfam01037 871585001464 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 871585001465 S-adenosylmethionine binding site [chemical binding]; other site 871585001466 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 871585001467 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 871585001468 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687 871585001469 Uncharacterized protein conserved in bacteria (DUF2171); Region: DUF2171; pfam09939 871585001470 potential frameshift: common BLAST hit: gi|299770863|ref|YP_003732889.1| putative acyl-CoA dehydrogenase-related protein 871585001471 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 871585001472 active site 871585001473 GlcNAc-PI de-N-acetylase; Region: PIG-L; pfam02585 871585001474 Methyltransferase domain; Region: Methyltransf_31; pfam13847 871585001475 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 871585001476 S-adenosylmethionine binding site [chemical binding]; other site 871585001477 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 871585001478 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 871585001479 active site 871585001480 Protein of unknown function (DUF3592); Region: DUF3592; pfam12158 871585001481 potential frameshift: common BLAST hit: gi|299770858|ref|YP_003732884.1| Mechanosensitive ion channel family protein 871585001482 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 871585001483 Mechanosensitive ion channel; Region: MS_channel; pfam00924 871585001484 Mechanosensitive ion channel; Region: MS_channel; pfam00924 871585001485 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 871585001486 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 871585001487 putative substrate translocation pore; other site 871585001488 Predicted transcriptional regulators [Transcription]; Region: COG1733 871585001489 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 871585001490 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dam; COG0338 871585001491 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 871585001492 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 871585001493 active site 871585001494 HIGH motif; other site 871585001495 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 871585001496 KMSKS motif; other site 871585001497 Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963 871585001498 tRNA binding surface [nucleotide binding]; other site 871585001499 anticodon binding site; other site 871585001500 D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892 871585001501 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 871585001502 putative active site [active] 871585001503 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 871585001504 HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662 871585001505 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 871585001506 active site 871585001507 motif I; other site 871585001508 motif II; other site 871585001509 Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835 871585001510 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3117; cl01200 871585001511 lipopolysaccharide transport periplasmic protein LptA; Region: outer_YhbN_LptA; TIGR03002 871585001512 OstA-like protein; Region: OstA; pfam03968 871585001513 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 871585001514 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 871585001515 Walker A/P-loop; other site 871585001516 ATP binding site [chemical binding]; other site 871585001517 Q-loop/lid; other site 871585001518 ABC transporter signature motif; other site 871585001519 Walker B; other site 871585001520 D-loop; other site 871585001521 H-loop/switch region; other site 871585001522 potential frameshift: common BLAST hit: gi|299770835|ref|YP_003732861.1| putative outer membrane efflux protein, type I secretion protein 871585001523 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 871585001524 Outer membrane efflux protein; Region: OEP; pfam02321 871585001525 type I secretion system ATPase, LssB family; Region: type_I_sec_LssB; TIGR03375 871585001526 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 871585001527 putative active site [active] 871585001528 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 871585001529 ATP-binding cassette domain of bacteriocin exporters, subfamily C; Region: ABCC_bacteriocin_exporters; cd03245 871585001530 Walker A/P-loop; other site 871585001531 ATP binding site [chemical binding]; other site 871585001532 Q-loop/lid; other site 871585001533 ABC transporter signature motif; other site 871585001534 Walker B; other site 871585001535 D-loop; other site 871585001536 H-loop/switch region; other site 871585001537 potential frameshift: common BLAST hit: gi|299770833|ref|YP_003732859.1| protein secretion efflux system ABC transporter membrane protein 871585001538 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 871585001539 HlyD family secretion protein; Region: HlyD; pfam00529 871585001540 HlyD family secretion protein; Region: HlyD_3; pfam13437 871585001541 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 871585001542 Uncharacterized conserved protein [Function unknown]; Region: COG1739 871585001543 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 871585001544 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cd00208 871585001545 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 871585001546 putative trimer interface [polypeptide binding]; other site 871585001547 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 871585001548 trimer interface [polypeptide binding]; other site 871585001549 active site 871585001550 substrate binding site [chemical binding]; other site 871585001551 putative CoA binding site [chemical binding]; other site 871585001552 CoA binding site [chemical binding]; other site 871585001553 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 871585001554 Ligand Binding Site [chemical binding]; other site 871585001555 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 871585001556 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 871585001557 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3108 871585001558 Ferredoxin [Energy production and conversion]; Region: COG1146 871585001559 4Fe-4S binding domain; Region: Fer4; pfam00037 871585001560 Domain of unknown function (DUF3470); Region: DUF3470; pfam11953 871585001561 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 871585001562 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 871585001563 Coenzyme A binding pocket [chemical binding]; other site 871585001564 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 871585001565 MutS domain I; Region: MutS_I; pfam01624 871585001566 MutS domain II; Region: MutS_II; pfam05188 871585001567 MutS domain III; Region: MutS_III; pfam05192 871585001568 MutS domain V; Region: MutS_V; pfam00488 871585001569 Walker A/P-loop; other site 871585001570 ATP binding site [chemical binding]; other site 871585001571 Q-loop/lid; other site 871585001572 ABC transporter signature motif; other site 871585001573 Walker B; other site 871585001574 D-loop; other site 871585001575 H-loop/switch region; other site 871585001576 4-aminobutyrate aminotransferase and related aminotransferases [Amino acid transport and metabolism]; Region: GabT; COG0160 871585001577 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 871585001578 inhibitor-cofactor binding pocket; inhibition site 871585001579 pyridoxal 5'-phosphate binding site [chemical binding]; other site 871585001580 catalytic residue [active] 871585001581 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 871585001582 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 871585001583 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 871585001584 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 871585001585 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 871585001586 active site 871585001587 substrate binding site [chemical binding]; other site 871585001588 Phosphotransferase enzyme family; Region: APH; pfam01636 871585001589 ATP binding site [chemical binding]; other site 871585001590 ethanolamine permease; Region: 2A0305; TIGR00908 871585001591 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 871585001592 DNA-binding site [nucleotide binding]; DNA binding site 871585001593 RNA-binding motif; other site 871585001594 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 871585001595 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 871585001596 Catalase-like heme-binding proteins similar to the uncharacterized srpA; Region: srpA_like; cd08153 871585001597 putative heme binding pocket [chemical binding]; other site 871585001598 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 871585001599 benzoate transport; Region: 2A0115; TIGR00895 871585001600 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 871585001601 putative substrate translocation pore; other site 871585001602 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 871585001603 Uncharacterized protein conserved in bacteria (DUF2147); Region: DUF2147; pfam09917 871585001604 Spore Coat Protein U domain; Region: SCPU; pfam05229 871585001605 Helix-Turn-Helix DNA binding domain of the transcription regulators NolA and AlbR; Region: HTH_NolA-AlbR; cd04788 871585001606 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 871585001607 DNA binding residues [nucleotide binding] 871585001608 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 871585001609 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 871585001610 Transcriptional regulator [Transcription]; Region: LysR; COG0583 871585001611 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 871585001612 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 871585001613 putative effector binding pocket; other site 871585001614 putative dimerization interface [polypeptide binding]; other site 871585001615 hypothetical protein; Provisional; Region: PRK08204 871585001616 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 871585001617 active site 871585001618 Protein of unknown function, DUF606; Region: DUF606; pfam04657 871585001619 potential frameshift: common BLAST hit: gi|299770767|ref|YP_003732793.1| outer membrane receptor for ferric coprogen and ferric-rhodotorulic 871585001620 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 871585001621 Secretin and TonB N terminus short domain; Region: STN; smart00965 871585001622 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 871585001623 N-terminal plug; other site 871585001624 ligand-binding site [chemical binding]; other site 871585001625 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 871585001626 FecR protein; Region: FecR; pfam04773 871585001627 RNA polymerase sigma factor; Provisional; Region: PRK12528 871585001628 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 871585001629 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 871585001630 DNA binding residues [nucleotide binding] 871585001631 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 871585001632 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 871585001633 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 871585001634 substrate binding pocket [chemical binding]; other site 871585001635 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 871585001636 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 871585001637 AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582 871585001638 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 871585001639 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 871585001640 LysE type translocator; Region: LysE; cl00565 871585001641 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 871585001642 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 871585001643 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 871585001644 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 871585001645 nucleophilic elbow; other site 871585001646 catalytic triad; other site 871585001647 Hydrolase of X-linked nucleoside diphosphate N terminal; Region: Nudix_N; pfam12535 871585001648 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_14; cd04672 871585001649 nudix motif; other site 871585001650 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 871585001651 Zn2+ binding site [ion binding]; other site 871585001652 Mg2+ binding site [ion binding]; other site 871585001653 SnoaL-like domain; Region: SnoaL_2; pfam12680 871585001654 Transcriptional regulator [Transcription]; Region: LysR; COG0583 871585001655 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 871585001656 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 871585001657 putative effector binding pocket; other site 871585001658 dimerization interface [polypeptide binding]; other site 871585001659 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 871585001660 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 871585001661 NAD(P) binding site [chemical binding]; other site 871585001662 active site 871585001663 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 871585001664 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 871585001665 Predicted transcriptional regulators [Transcription]; Region: COG1733 871585001666 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 871585001667 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 871585001668 triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269 871585001669 NADP binding site [chemical binding]; other site 871585001670 Domain of unknown function (DUF4424); Region: DUF4424; pfam14415 871585001671 DoxX; Region: DoxX; pfam07681 871585001672 hypothetical protein; Provisional; Region: PRK05409 871585001673 Uncharacterized protein conserved in bacteria (DUF2063); Region: DUF2063; cl01262 871585001674 RNA polymerase sigma factor; Provisional; Region: PRK12544 871585001675 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 871585001676 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 871585001677 DNA binding residues [nucleotide binding] 871585001678 Putative zinc-finger; Region: zf-HC2; pfam13490 871585001679 transcriptional regulator, ArgP family; Region: argP; TIGR03298 871585001680 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 871585001681 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 871585001682 dimerization interface [polypeptide binding]; other site 871585001683 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 871585001684 LamB/YcsF family of lactam utilization protein; Region: LamB_YcsF_like; cd10787 871585001685 putative active site [active] 871585001686 hypothetical protein; Provisional; Region: PRK05463 871585001687 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 871585001688 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049 871585001689 Allophanate hydrolase subunit 2; Region: AHS2; pfam02626 871585001690 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 871585001691 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 871585001692 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 871585001693 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 871585001694 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 871585001695 carboxyltransferase (CT) interaction site; other site 871585001696 biotinylation site [posttranslational modification]; other site 871585001697 potential frameshift: common BLAST hit: gi|215483938|ref|YP_002326163.1| Voltage gated chloride channel family protein 871585001698 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 871585001699 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cl02915 871585001700 Cl- selectivity filter; other site 871585001701 pore gating glutamate residue; other site 871585001702 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cl02915 871585001703 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 871585001704 dimer interface [polypeptide binding]; other site 871585001705 Predicted NTPase (NACHT family) [Signal transduction mechanisms]; Region: COG5635 871585001706 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 871585001707 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 871585001708 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 871585001709 putative hydrophobic ligand binding site [chemical binding]; other site 871585001710 protein interface [polypeptide binding]; other site 871585001711 gate; other site 871585001712 aromatic amino acid exporter; Provisional; Region: PRK11689 871585001713 EamA-like transporter family; Region: EamA; pfam00892 871585001714 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07066 871585001715 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 871585001716 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 871585001717 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 871585001718 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 871585001719 NAD binding site [chemical binding]; other site 871585001720 catalytic Zn binding site [ion binding]; other site 871585001721 structural Zn binding site [ion binding]; other site 871585001722 urea carboxylase-associated protein 1; Region: urea_degr_1; TIGR03424 871585001723 urea carboxylase-associated protein 2; Region: urea_degr_2; TIGR03425 871585001724 urea carboxylase-associated protein 1; Region: urea_degr_1; TIGR03424 871585001725 Domain of unknown function (DUF1989); Region: DUF1989; pfam09347 871585001726 urea carboxylase; Region: urea_carbox; TIGR02712 871585001727 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 871585001728 ATP-grasp domain; Region: ATP-grasp_4; cl17255 871585001729 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 871585001730 Allophanate hydrolase subunit 2; Region: AHS2; smart00797 871585001731 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896 871585001732 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 871585001733 carboxyltransferase (CT) interaction site; other site 871585001734 biotinylation site [posttranslational modification]; other site 871585001735 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 871585001736 Predicted transcriptional regulators [Transcription]; Region: COG1733 871585001737 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 871585001738 putative DNA binding site [nucleotide binding]; other site 871585001739 putative Zn2+ binding site [ion binding]; other site 871585001740 AAA domain; Region: AAA_21; pfam13304 871585001741 nickel responsive regulator; Provisional; Region: PRK04460 871585001742 NikR C terminal nickel binding domain; Region: NikR_C; pfam08753 871585001743 allophanate hydrolase; Provisional; Region: PRK08186 871585001744 Amidase; Region: Amidase; pfam01425 871585001745 ABC transporter periplasmic binding protein, urea carboxylase region; Region: ABC_peri_uca; TIGR03427 871585001746 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 871585001747 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 871585001748 Walker A/P-loop; other site 871585001749 ATP binding site [chemical binding]; other site 871585001750 Q-loop/lid; other site 871585001751 ABC transporter signature motif; other site 871585001752 Walker B; other site 871585001753 D-loop; other site 871585001754 H-loop/switch region; other site 871585001755 potential frameshift: common BLAST hit: gi|215483920|ref|YP_002326145.1| Taurine transport system permease protein tauC 871585001756 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 871585001757 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 871585001758 dimer interface [polypeptide binding]; other site 871585001759 conserved gate region; other site 871585001760 ABC-ATPase subunit interface; other site 871585001761 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4460 871585001762 Uncharacterized protein conserved in bacteria [Function unknown]; Region: VgrG; COG3501 871585001763 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 871585001764 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 871585001765 Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296 871585001766 Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; pfam10106 871585001767 Domain of unknown function (DUF1911); Region: DUF1911; pfam08929 871585001768 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 871585001769 RHS protein; Region: RHS; pfam03527 871585001770 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 871585001771 Uncharacterized protein conserved in bacteria [Function unknown]; Region: VgrG; COG3501 871585001772 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 871585001773 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 871585001774 Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296 871585001775 Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; pfam10106 871585001776 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 871585001777 Sel1-like repeats; Region: SEL1; smart00671 871585001778 Sel1-like repeats; Region: SEL1; smart00671 871585001779 Sel1-like repeats; Region: SEL1; smart00671 871585001780 Sel1 repeat; Region: Sel1; pfam08238 871585001781 Sel1-like repeats; Region: SEL1; smart00671 871585001782 Sel1-like repeats; Region: SEL1; smart00671 871585001783 Protein of unknown function (DUF770); Region: DUF770; pfam05591 871585001784 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3517; cl05484 871585001785 Protein of unknown function (DUF877); Region: DUF877; pfam05943 871585001786 Protein of unknown function (DUF796); Region: DUF796; pfam05638 871585001787 type VI secretion system lysozyme-like protein; Region: VI_zyme; TIGR03357 871585001788 Type VI protein secretion system component VasA [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3519 871585001789 Bacterial protein of unknown function (DUF879); Region: DUF879; cl15462 871585001790 Protein of unknown function (DUF1305); Region: DUF1305; pfam06996 871585001791 potential frameshift: common BLAST hit: gi|299770680|ref|YP_003732706.1| type VI secretion protein IcmF 871585001792 Type VI protein secretion system component VasK [Intracellular trafficking, secretion, and vesicular transport]; Region: IcmF; COG3523 871585001793 potential frameshift: common BLAST hit: gi|299770680|ref|YP_003732706.1| type VI secretion protein IcmF 871585001794 ImcF-related N-terminal domain; Region: ImcF-related_N; pfam14331 871585001795 Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761 871585001796 Protein of unknown function (DUF1215); Region: DUF1215; pfam06744 871585001797 type VI secretion protein IcmF; Region: VI_IcmF; TIGR03348 871585001798 Uncharacterized protein conserved in bacteria (DUF2094); Region: DUF2094; cl01611 871585001799 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 871585001800 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 871585001801 ligand binding site [chemical binding]; other site 871585001802 type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345 871585001803 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 871585001804 Walker A motif; other site 871585001805 ATP binding site [chemical binding]; other site 871585001806 Walker B motif; other site 871585001807 arginine finger; other site 871585001808 JNK_SAPK-associated protein-1; Region: Jnk-SapK_ap_N; pfam09744 871585001809 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 871585001810 Walker A motif; other site 871585001811 ATP binding site [chemical binding]; other site 871585001812 Walker B motif; other site 871585001813 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 871585001814 type VI secretion-associated protein, ImpA family; Region: VI_chp_8; TIGR03363 871585001815 ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812 871585001816 type VI secretion protein, VC_A0114 family; Region: VI_chp_4; TIGR03353 871585001817 Bacterial protein of unknown function (DUF876); Region: DUF876; pfam05936 871585001818 type IV / VI secretion system protein, DotU family; Region: IV_VI_DotU; TIGR03349 871585001819 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 871585001820 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_M15_4; pfam13539 871585001821 Transcriptional regulator [Transcription]; Region: LysR; COG0583 871585001822 LysR substrate binding domain; Region: LysR_substrate; pfam03466 871585001823 dimerization interface [polypeptide binding]; other site 871585001824 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 871585001825 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 871585001826 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 871585001827 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 871585001828 nucleoside/Zn binding site; other site 871585001829 dimer interface [polypeptide binding]; other site 871585001830 catalytic motif [active] 871585001831 putative cyanate transporter; Provisional; Region: cynX; PRK09705 871585001832 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214 871585001833 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 871585001834 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 871585001835 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 871585001836 Coenzyme A binding pocket [chemical binding]; other site 871585001837 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 871585001838 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 871585001839 DNA-binding site [nucleotide binding]; DNA binding site 871585001840 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 871585001841 pyridoxal 5'-phosphate binding site [chemical binding]; other site 871585001842 homodimer interface [polypeptide binding]; other site 871585001843 catalytic residue [active] 871585001844 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1636 871585001845 redox-sensitive transcriptional activator SoxR; Region: SoxR; TIGR01950 871585001846 Helix-Turn-Helix DNA binding domain of the SoxR transcription regulator; Region: HTH_SoxR; cd01110 871585001847 DNA binding residues [nucleotide binding] 871585001848 dimer interface [polypeptide binding]; other site 871585001849 [2Fe-2S] cluster binding site [ion binding]; other site 871585001850 Putative hemolysin [General function prediction only]; Region: Hlx; COG3042 871585001851 Domain of unknown function (DUF333); Region: DUF333; pfam03891 871585001852 Peptidase inhibitor I78 family; Region: Inhibitor_I78; pfam11720 871585001853 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 871585001854 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 871585001855 active site 871585001856 inhibitor site; inhibition site 871585001857 dimer interface [polypeptide binding]; other site 871585001858 catalytic residue [active] 871585001859 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 871585001860 EamA-like transporter family; Region: EamA; pfam00892 871585001861 Transcriptional regulators [Transcription]; Region: GntR; COG1802 871585001862 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 871585001863 DNA-binding site [nucleotide binding]; DNA binding site 871585001864 FCD domain; Region: FCD; pfam07729 871585001865 hydroxyproline-2-epimerase; Provisional; Region: PRK13970 871585001866 hydroxyproline-2-epimerase; Provisional; Region: PRK13971 871585001867 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 871585001868 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 871585001869 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510 871585001870 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 871585001871 PAS fold; Region: PAS_4; pfam08448 871585001872 Helix-turn-helix domain; Region: HTH_18; pfam12833 871585001873 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 871585001874 metabolite-proton symporter; Region: 2A0106; TIGR00883 871585001875 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 871585001876 putative substrate translocation pore; other site 871585001877 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 871585001878 Alpha-Ketoglutaric Semialdehyde Dehydrogenase; Region: ALDH_KGSADH; cd07129 871585001879 dimer interface [polypeptide binding]; other site 871585001880 NADP binding site [chemical binding]; other site 871585001881 catalytic residues [active] 871585001882 amino acid transporter; Region: 2A0306; TIGR00909 871585001883 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 871585001884 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 871585001885 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 871585001886 bifunctional aldehyde dehydrogenase/enoyl-CoA hydratase; Provisional; Region: PRK11563 871585001887 N-terminal domain of the monoamine oxidase C dehydratase; Region: ALDH_MaoC-N; cd07128 871585001888 substrate binding site [chemical binding]; other site 871585001889 dimer interface [polypeptide binding]; other site 871585001890 NADP binding site [chemical binding]; other site 871585001891 catalytic residues [active] 871585001892 MaoC_C The C-terminal hot dog fold of the MaoC (monoamine oxidase C) dehydratase regulatory protein. Orthologs of MaoC include PaaZ [Escherichia coli] and PaaN [Pseudomonas putida], which are putative ring-opening enzymes involved in phenylacetic acid...; Region: MaoC_C; cd03452 871585001893 substrate binding site [chemical binding]; other site 871585001894 phenylacetate-CoA oxygenase subunit PaaA; Provisional; Region: paaA; PRK13778 871585001895 phenylacetate-CoA oxygenase, PaaG subunit; Region: PA_CoA_Oxy1; TIGR02156 871585001896 phenylacetate-CoA oxygenase subunit PaaB; Provisional; Region: paaB; PRK13781 871585001897 Phenylacetic acid catabolic protein; Region: PaaA_PaaC; pfam05138 871585001898 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 871585001899 phenylacetate-CoA oxygenase, PaaJ subunit; Region: PA_CoA_Oxy4; TIGR02159 871585001900 potential frameshift: common BLAST hit: gi|299770817|ref|YP_003732843.1| flavodoxin reductase (ferredoxin-NADPH reductase) family protein 1 871585001901 NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214 871585001902 FAD binding pocket [chemical binding]; other site 871585001903 FAD binding motif [chemical binding]; other site 871585001904 phosphate binding motif [ion binding]; other site 871585001905 beta-alpha-beta structure motif; other site 871585001906 NAD(p) ribose binding residues [chemical binding]; other site 871585001907 NAD binding pocket [chemical binding]; other site 871585001908 NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site 871585001909 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 871585001910 catalytic loop [active] 871585001911 iron binding site [ion binding]; other site 871585001912 enoyl-CoA hydratase-isomerase; Provisional; Region: PRK09674 871585001913 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 871585001914 substrate binding site [chemical binding]; other site 871585001915 oxyanion hole (OAH) forming residues; other site 871585001916 trimer interface [polypeptide binding]; other site 871585001917 enoyl-CoA hydratase; Provisional; Region: PRK08140 871585001918 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 871585001919 substrate binding site [chemical binding]; other site 871585001920 oxyanion hole (OAH) forming residues; other site 871585001921 trimer interface [polypeptide binding]; other site 871585001922 3-hydroxy-acyl-CoA dehydrogenase; Validated; Region: PRK08268 871585001923 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 871585001924 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 871585001925 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 871585001926 beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050 871585001927 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 871585001928 dimer interface [polypeptide binding]; other site 871585001929 active site 871585001930 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 871585001931 phenylacetate-CoA ligase; Region: PA_CoA_ligase; TIGR02155 871585001932 acyl-activating enzyme (AAE) consensus motif; other site 871585001933 AMP binding site [chemical binding]; other site 871585001934 active site 871585001935 CoA binding site [chemical binding]; other site 871585001936 PaaX-like protein; Region: PaaX; pfam07848 871585001937 phenylacetic acid degradation operon negative regulatory protein PaaX; Region: PaaX_trns_reg; TIGR02277 871585001938 PaaX-like protein C-terminal domain; Region: PaaX_C; pfam08223 871585001939 phenylacetic acid degradation protein PaaY; Region: PaaY; TIGR02287 871585001940 paaY-like: This group is composed by uncharacterized proteins with similarity to the protein product of the E. coli paaY gene, which is part of the paa gene cluster responsible for phenylacetic acid degradation. Proteins in this group are expected to...; Region: LbH_paaY_like; cd04745 871585001941 putative trimer interface [polypeptide binding]; other site 871585001942 putative metal binding site [ion binding]; other site 871585001943 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 871585001944 CoenzymeA binding site [chemical binding]; other site 871585001945 subunit interaction site [polypeptide binding]; other site 871585001946 PHB binding site; other site 871585001947 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 871585001948 ATP binding site [chemical binding]; other site 871585001949 Mg2+ binding site [ion binding]; other site 871585001950 G-X-G motif; other site 871585001951 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 871585001952 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 871585001953 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 871585001954 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 871585001955 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 871585001956 GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046 871585001957 putative C-terminal domain interface [polypeptide binding]; other site 871585001958 putative GSH binding site (G-site) [chemical binding]; other site 871585001959 putative dimer interface [polypeptide binding]; other site 871585001960 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 871585001961 N-terminal domain interface [polypeptide binding]; other site 871585001962 dimer interface [polypeptide binding]; other site 871585001963 substrate binding pocket (H-site) [chemical binding]; other site 871585001964 Uncharacterized conserved protein [Function unknown]; Region: COG5470 871585001965 Transcriptional regulators [Transcription]; Region: GntR; COG1802 871585001966 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 871585001967 DNA-binding site [nucleotide binding]; DNA binding site 871585001968 FCD domain; Region: FCD; cl11656 871585001969 Amino acid synthesis; Region: AA_synth; pfam06684 871585001970 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 871585001971 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 871585001972 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 871585001973 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 871585001974 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 871585001975 Uncharacterized Candidatus pelagibacter aldehyde dehydrogenase, DhaS-like; Region: ALDH_DhaS; cd07114 871585001976 NAD(P) binding site [chemical binding]; other site 871585001977 catalytic residues [active] 871585001978 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 871585001979 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 871585001980 succinic semialdehyde dehydrogenase; Region: PLN02278 871585001981 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 871585001982 tetramerization interface [polypeptide binding]; other site 871585001983 NAD(P) binding site [chemical binding]; other site 871585001984 catalytic residues [active] 871585001985 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 871585001986 Transcriptional regulator [Transcription]; Region: LysR; COG0583 871585001987 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 871585001988 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_6; cd08475 871585001989 putative effector binding pocket; other site 871585001990 putative dimerization interface [polypeptide binding]; other site 871585001991 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 871585001992 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 871585001993 beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Region: pcaR_pcaU; TIGR02431 871585001994 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 871585001995 Bacterial transcriptional regulator; Region: IclR; pfam01614 871585001996 4-hydroxybenzoate 3-monooxygenase; Validated; Region: PRK08243 871585001997 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 871585001998 NAD(P) binding site [chemical binding]; other site 871585001999 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 871585002000 alanine racemase; Reviewed; Region: PRK13340 871585002001 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme, Alanine Racemase 2; Region: PLPDE_III_AR2; cd06826 871585002002 active site 871585002003 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 871585002004 dimer interface [polypeptide binding]; other site 871585002005 substrate binding site [chemical binding]; other site 871585002006 catalytic residues [active] 871585002007 transcriptional regulator protein; Region: phnR; TIGR03337 871585002008 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 871585002009 DNA-binding site [nucleotide binding]; DNA binding site 871585002010 UTRA domain; Region: UTRA; pfam07702 871585002011 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 871585002012 ABC-type thiamine transport system, periplasmic component [Coenzyme metabolism]; Region: TbpA; COG4143 871585002013 putative 2-aminoethylphosphonate ABC transporter, ATP-binding protein; Region: PhnT2; TIGR03265 871585002014 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 871585002015 Walker A/P-loop; other site 871585002016 ATP binding site [chemical binding]; other site 871585002017 Q-loop/lid; other site 871585002018 ABC transporter signature motif; other site 871585002019 Walker B; other site 871585002020 D-loop; other site 871585002021 H-loop/switch region; other site 871585002022 putative 2-aminoethylphosphonate ABC transporter, permease protein; Region: PhnU2; TIGR03262 871585002023 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 871585002024 dimer interface [polypeptide binding]; other site 871585002025 conserved gate region; other site 871585002026 putative PBP binding loops; other site 871585002027 ABC-ATPase subunit interface; other site 871585002028 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 871585002029 dimer interface [polypeptide binding]; other site 871585002030 conserved gate region; other site 871585002031 putative PBP binding loops; other site 871585002032 ABC-ATPase subunit interface; other site 871585002033 FAD dependent oxidoreductase TIGR03364; Region: HpnW_proposed 871585002034 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 871585002035 2-aminoethylphosphonate--pyruvate transaminase; Provisional; Region: PRK13479 871585002036 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 871585002037 catalytic residue [active] 871585002038 phosphonoacetaldehyde hydrolase; Provisional; Region: PRK13478 871585002039 benzoate transport; Region: 2A0115; TIGR00895 871585002040 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 871585002041 putative substrate translocation pore; other site 871585002042 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 871585002043 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 871585002044 active site 871585002045 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 871585002046 CoA-transferase family III; Region: CoA_transf_3; pfam02515 871585002047 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 871585002048 Transcriptional regulator [Transcription]; Region: IclR; COG1414 871585002049 Bacterial transcriptional regulator; Region: IclR; pfam01614 871585002050 enoyl-CoA hydratase; Provisional; Region: PRK06688 871585002051 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 871585002052 substrate binding site [chemical binding]; other site 871585002053 oxyanion hole (OAH) forming residues; other site 871585002054 trimer interface [polypeptide binding]; other site 871585002055 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 871585002056 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 871585002057 FMN binding site [chemical binding]; other site 871585002058 substrate binding site [chemical binding]; other site 871585002059 putative catalytic residue [active] 871585002060 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 871585002061 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 871585002062 putative substrate translocation pore; other site 871585002063 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 871585002064 Transcriptional regulator [Transcription]; Region: IclR; COG1414 871585002065 Bacterial transcriptional regulator; Region: IclR; pfam01614 871585002066 acetyl-CoA acetyltransferase; Provisional; Region: PRK08131 871585002067 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 871585002068 dimer interface [polypeptide binding]; other site 871585002069 active site 871585002070 3-hydroxy-acyl-CoA dehydrogenase; Validated; Region: PRK08268 871585002071 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 871585002072 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 871585002073 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 871585002074 3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826 871585002075 classical (c) SDRs; Region: SDR_c; cd05233 871585002076 NAD(P) binding site [chemical binding]; other site 871585002077 active site 871585002078 enoyl-CoA hydratase; Provisional; Region: PRK08138 871585002079 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 871585002080 substrate binding site [chemical binding]; other site 871585002081 oxyanion hole (OAH) forming residues; other site 871585002082 trimer interface [polypeptide binding]; other site 871585002083 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 871585002084 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 871585002085 active site 871585002086 benzoate transport; Region: 2A0115; TIGR00895 871585002087 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 871585002088 putative substrate translocation pore; other site 871585002089 3-oxoacid CoA-transferase, A subunit; Region: pcaI_scoA_fam; TIGR02429 871585002090 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 871585002091 Maltoporin periplasmic N-terminal extension; Region: Sugarporin_N; pfam11471 871585002092 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 871585002093 Major Facilitator Superfamily; Region: MFS_1; pfam07690 871585002094 putative substrate translocation pore; other site 871585002095 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 871585002096 CoenzymeA binding site [chemical binding]; other site 871585002097 subunit interaction site [polypeptide binding]; other site 871585002098 PHB binding site; other site 871585002099 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 871585002100 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 871585002101 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 871585002102 active site 871585002103 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 871585002104 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 871585002105 indolepyruvate ferredoxin oxidoreductase; Validated; Region: PRK09193 871585002106 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 871585002107 dimer interface [polypeptide binding]; other site 871585002108 PYR/PP interface [polypeptide binding]; other site 871585002109 TPP binding site [chemical binding]; other site 871585002110 substrate binding site [chemical binding]; other site 871585002111 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 871585002112 TPP-binding site [chemical binding]; other site 871585002113 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 871585002114 Transcriptional regulator [Transcription]; Region: LysR; COG0583 871585002115 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 871585002116 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 871585002117 putative effector binding pocket; other site 871585002118 dimerization interface [polypeptide binding]; other site 871585002119 Isopropylmalate/homocitrate/citramalate synthases [Amino acid transport and metabolism]; Region: LeuA; COG0119 871585002120 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 871585002121 active site 871585002122 catalytic residues [active] 871585002123 metal binding site [ion binding]; metal-binding site 871585002124 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 871585002125 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 871585002126 ATP-grasp domain; Region: ATP-grasp_4; cl17255 871585002127 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 871585002128 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 871585002129 carboxyltransferase (CT) interaction site; other site 871585002130 biotinylation site [posttranslational modification]; other site 871585002131 enoyl-CoA hydratase; Provisional; Region: PRK05995 871585002132 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 871585002133 substrate binding site [chemical binding]; other site 871585002134 oxyanion hole (OAH) forming residues; other site 871585002135 trimer interface [polypeptide binding]; other site 871585002136 3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820 871585002137 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 871585002138 isovaleryl-CoA dehydrogenase; Region: PLN02519 871585002139 Isovaleryl-CoA dehydrogenase; Region: IVD; cd01156 871585002140 substrate binding site [chemical binding]; other site 871585002141 FAD binding site [chemical binding]; other site 871585002142 catalytic base [active] 871585002143 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 871585002144 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 871585002145 AMP-binding domain protein; Validated; Region: PRK08315 871585002146 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 871585002147 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917 871585002148 acyl-activating enzyme (AAE) consensus motif; other site 871585002149 putative AMP binding site [chemical binding]; other site 871585002150 putative active site [active] 871585002151 putative CoA binding site [chemical binding]; other site 871585002152 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 871585002153 S-adenosylmethionine binding site [chemical binding]; other site 871585002154 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 871585002155 benzoate transport; Region: 2A0115; TIGR00895 871585002156 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 871585002157 putative substrate translocation pore; other site 871585002158 SGNH_hydrolase subfamily, similar to the putative arylesterase/acylhydrolase from the rumen anaerobe Prevotella bryantii XynE. The P. bryantii XynE gene is located in a xylanase gene cluster. SGNH hydrolases are a diverse family of lipases and esterases; Region: XynE_like; cd01830 871585002159 active site 871585002160 catalytic triad [active] 871585002161 oxyanion hole [active] 871585002162 Transcriptional regulator [Transcription]; Region: LysR; COG0583 871585002163 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 871585002164 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 871585002165 putative effector binding pocket; other site 871585002166 dimerization interface [polypeptide binding]; other site 871585002167 Competence-damaged protein; Region: CinA; pfam02464 871585002168 hydroperoxidase II; Provisional; Region: katE; PRK11249 871585002169 Clade 2 of the heme-binding enzyme catalase; Region: catalase_clade_2; cd08155 871585002170 tetramer interface [polypeptide binding]; other site 871585002171 heme binding pocket [chemical binding]; other site 871585002172 Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132 871585002173 domain interactions; other site 871585002174 short chain dehydrogenase; Provisional; Region: PRK06701 871585002175 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 871585002176 NAD binding site [chemical binding]; other site 871585002177 metal binding site [ion binding]; metal-binding site 871585002178 active site 871585002179 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 871585002180 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 871585002181 Catalytic site [active] 871585002182 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 871585002183 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 871585002184 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 871585002185 putative DNA binding site [nucleotide binding]; other site 871585002186 putative Zn2+ binding site [ion binding]; other site 871585002187 AsnC family; Region: AsnC_trans_reg; pfam01037 871585002188 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 871585002189 Na binding site [ion binding]; other site 871585002190 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 871585002191 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 871585002192 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 871585002193 dimer interface [polypeptide binding]; other site 871585002194 phosphorylation site [posttranslational modification] 871585002195 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 871585002196 ATP binding site [chemical binding]; other site 871585002197 Mg2+ binding site [ion binding]; other site 871585002198 G-X-G motif; other site 871585002199 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 871585002200 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 871585002201 active site 871585002202 phosphorylation site [posttranslational modification] 871585002203 intermolecular recognition site; other site 871585002204 dimerization interface [polypeptide binding]; other site 871585002205 Response regulator receiver domain; Region: Response_reg; pfam00072 871585002206 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 871585002207 active site 871585002208 phosphorylation site [posttranslational modification] 871585002209 intermolecular recognition site; other site 871585002210 dimerization interface [polypeptide binding]; other site 871585002211 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 871585002212 DNA binding residues [nucleotide binding] 871585002213 dimerization interface [polypeptide binding]; other site 871585002214 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 871585002215 Coenzyme A binding pocket [chemical binding]; other site 871585002216 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 871585002217 dimer interface [polypeptide binding]; other site 871585002218 conserved gate region; other site 871585002219 putative PBP binding loops; other site 871585002220 ABC-ATPase subunit interface; other site 871585002221 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 871585002222 dimer interface [polypeptide binding]; other site 871585002223 conserved gate region; other site 871585002224 putative PBP binding loops; other site 871585002225 ABC-ATPase subunit interface; other site 871585002226 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 871585002227 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 871585002228 Walker A/P-loop; other site 871585002229 ATP binding site [chemical binding]; other site 871585002230 Q-loop/lid; other site 871585002231 ABC transporter signature motif; other site 871585002232 Walker B; other site 871585002233 D-loop; other site 871585002234 H-loop/switch region; other site 871585002235 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 871585002236 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 871585002237 substrate binding pocket [chemical binding]; other site 871585002238 membrane-bound complex binding site; other site 871585002239 hinge residues; other site 871585002240 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 871585002241 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 871585002242 substrate binding pocket [chemical binding]; other site 871585002243 membrane-bound complex binding site; other site 871585002244 hinge residues; other site 871585002245 Transcriptional regulator [Transcription]; Region: LysR; COG0583 871585002246 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 871585002247 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 871585002248 putative effector binding pocket; other site 871585002249 dimerization interface [polypeptide binding]; other site 871585002250 LysE type translocator; Region: LysE; cl00565 871585002251 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 871585002252 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 871585002253 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 871585002254 catalytic residue [active] 871585002255 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 871585002256 trimer interface [polypeptide binding]; other site 871585002257 active site 871585002258 substrate binding site [chemical binding]; other site 871585002259 CoA binding site [chemical binding]; other site 871585002260 Member of the Rhodanese Homology Domain superfamily, subgroup 1. This CD includes the putative rhodanese-related sulfurtransferases of several uncharacterized proteins; Region: RHOD_1; cd01522 871585002261 active site residue [active] 871585002262 short chain dehydrogenase; Provisional; Region: PRK12937 871585002263 tetrahydroxynaphthalene/trihydroxynaphthalene reductase-like, classical (c) SDRs; Region: THN_reductase-like_SDR_c; cd05362 871585002264 NADP binding site [chemical binding]; other site 871585002265 homodimer interface [polypeptide binding]; other site 871585002266 active site 871585002267 substrate binding site [chemical binding]; other site 871585002268 Transcriptional regulator [Transcription]; Region: LysR; COG0583 871585002269 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 871585002270 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 871585002271 putative effector binding pocket; other site 871585002272 putative dimerization interface [polypeptide binding]; other site 871585002273 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 871585002274 Helix-turn-helix domain; Region: HTH_18; pfam12833 871585002275 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 871585002276 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 871585002277 Protein of unknown function (DUF2000); Region: DUF2000; pfam09391 871585002278 putative S-transferase; Provisional; Region: PRK11752 871585002279 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 871585002280 C-terminal domain interface [polypeptide binding]; other site 871585002281 GSH binding site (G-site) [chemical binding]; other site 871585002282 dimer interface [polypeptide binding]; other site 871585002283 C-terminal, alpha helical domain of Escherichia coli Yghu Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YghU_like; cd10292 871585002284 dimer interface [polypeptide binding]; other site 871585002285 N-terminal domain interface [polypeptide binding]; other site 871585002286 active site 871585002287 glutathione S-transferase; Provisional; Region: PRK15113 871585002288 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 871585002289 C-terminal domain interface [polypeptide binding]; other site 871585002290 GSH binding site (G-site) [chemical binding]; other site 871585002291 dimer interface [polypeptide binding]; other site 871585002292 C-terminal, alpha helical domain of an unknown subfamily 4 of Glutathione S-transferases; Region: GST_C_4; cd03195 871585002293 putative dimer interface [polypeptide binding]; other site 871585002294 N-terminal domain interface [polypeptide binding]; other site 871585002295 putative substrate binding pocket (H-site) [chemical binding]; other site 871585002296 Transcriptional regulator [Transcription]; Region: LysR; COG0583 871585002297 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 871585002298 The C-terminal substrate binding domain of LysR-like transcriptional regulator CidR, contains the type 2 periplasmic binding fold; Region: PBP2_CidR; cd08438 871585002299 putative dimerization interface [polypeptide binding]; other site 871585002300 LrgA family; Region: LrgA; cl00608 871585002301 Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346 871585002302 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 871585002303 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 871585002304 DNA-binding site [nucleotide binding]; DNA binding site 871585002305 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 871585002306 pyridoxal 5'-phosphate binding site [chemical binding]; other site 871585002307 homodimer interface [polypeptide binding]; other site 871585002308 catalytic residue [active] 871585002309 Transcriptional regulator [Transcription]; Region: PaiB; COG2808 871585002310 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 871585002311 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 871585002312 Major Facilitator Superfamily; Region: MFS_1; pfam07690 871585002313 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 871585002314 putative substrate translocation pore; other site 871585002315 malonate decarboxylase, alpha subunit; Region: mdcA; TIGR01110 871585002316 triphosphoribosyl-dephospho-CoA synthase; Validated; Region: PRK01237 871585002317 malonate decarboxylase subunit delta; Provisional; Region: PRK01220 871585002318 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189 871585002319 malonate decarboxylase, gamma subunit; Region: malonate_gamma; TIGR03134 871585002320 phosphoribosyl-dephospho-CoA transferase; Provisional; Region: PRK01293 871585002321 Phosphoribosyl-dephospho-CoA transferase MdcG; Region: MdcG; pfam10620 871585002322 malonate decarboxylase, epsilon subunit; Region: malonate_mdcH; TIGR03131 871585002323 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 871585002324 malonate transporter, MadL subunit; Region: malonate_madL; TIGR00807 871585002325 malonate transporter, MadM subunit; Region: malonate_madM; TIGR00808 871585002326 Transcriptional regulator [Transcription]; Region: LysR; COG0583 871585002327 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 871585002328 The C-terminal substrate-binding domian of LysR-type transcriptional regulator MdcR, which involved in the malonate catabolism contains the type 2 periplasmic binding fold; Region: PBP2_MdcR; cd08416 871585002329 putative dimerization interface [polypeptide binding]; other site 871585002330 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 871585002331 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 871585002332 DNA-binding site [nucleotide binding]; DNA binding site 871585002333 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 871585002334 pyridoxal 5'-phosphate binding site [chemical binding]; other site 871585002335 homodimer interface [polypeptide binding]; other site 871585002336 catalytic residue [active] 871585002337 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 871585002338 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 871585002339 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 871585002340 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 871585002341 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 871585002342 active site 871585002343 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 871585002344 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 871585002345 active site 871585002346 non-prolyl cis peptide bond; other site 871585002347 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 871585002348 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 871585002349 putative substrate translocation pore; other site 871585002350 taurine ABC transporter, periplasmic binding protein; Region: taurine_ABC_bnd; TIGR01729 871585002351 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 871585002352 substrate binding pocket [chemical binding]; other site 871585002353 membrane-bound complex binding site; other site 871585002354 hinge residues; other site 871585002355 taurine transporter ATP-binding subunit; Provisional; Region: tauB; PRK11248 871585002356 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 871585002357 Walker A/P-loop; other site 871585002358 ATP binding site [chemical binding]; other site 871585002359 Q-loop/lid; other site 871585002360 ABC transporter signature motif; other site 871585002361 Walker B; other site 871585002362 D-loop; other site 871585002363 H-loop/switch region; other site 871585002364 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 871585002365 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 871585002366 dimer interface [polypeptide binding]; other site 871585002367 conserved gate region; other site 871585002368 putative PBP binding loops; other site 871585002369 ABC-ATPase subunit interface; other site 871585002370 taurine dioxygenase; Reviewed; Region: tauD; PRK09553 871585002371 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 871585002372 active site 871585002373 iron coordination sites [ion binding]; other site 871585002374 substrate binding pocket [chemical binding]; other site 871585002375 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 871585002376 uncharacterized nucleobase-cation-symport-1 (NCS1) transporter subfamily; solute-binding domain; Region: SLC-NCS1sbd_u1; cd11555 871585002377 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 871585002378 Na binding site [ion binding]; other site 871585002379 putative substrate binding site [chemical binding]; other site 871585002380 Transcriptional regulators [Transcription]; Region: GntR; COG1802 871585002381 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 871585002382 DNA-binding site [nucleotide binding]; DNA binding site 871585002383 FCD domain; Region: FCD; pfam07729 871585002384 Transcriptional regulator [Transcription]; Region: LysR; COG0583 871585002385 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 871585002386 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 871585002387 putative effector binding pocket; other site 871585002388 dimerization interface [polypeptide binding]; other site 871585002389 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 871585002390 Isochorismatase family; Region: Isochorismatase; pfam00857 871585002391 catalytic triad [active] 871585002392 dimer interface [polypeptide binding]; other site 871585002393 conserved cis-peptide bond; other site 871585002394 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 871585002395 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 871585002396 active site 871585002397 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 871585002398 ArsC family; Region: ArsC; pfam03960 871585002399 catalytic residues [active] 871585002400 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 871585002401 dimerization interface [polypeptide binding]; other site 871585002402 putative DNA binding site [nucleotide binding]; other site 871585002403 putative Zn2+ binding site [ion binding]; other site 871585002404 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 871585002405 arsenical-resistance protein; Region: acr3; TIGR00832 871585002406 Transcriptional regulator [Transcription]; Region: LysR; COG0583 871585002407 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 871585002408 The C-terminal substrate binding domain of LysR-type transcrptional regulator BudR, which is responsible for activation of the expression of the butanediol operon genes; contains the type 2 periplasmic binding fold; Region: PBP2_BudR; cd08451 871585002409 putative dimerization interface [polypeptide binding]; other site 871585002410 putative substrate binding pocket [chemical binding]; other site 871585002411 Chromate transporter; Region: Chromate_transp; pfam02417 871585002412 Chromate transporter; Region: Chromate_transp; pfam02417 871585002413 alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317 871585002414 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974 871585002415 catalytic residue [active] 871585002416 TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026 871585002417 catalytic residues [active] 871585002418 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 871585002419 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 871585002420 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 871585002421 PGAP1-like protein; Region: PGAP1; pfam07819 871585002422 serine O-acetyltransferase; Region: cysE; TIGR01172 871585002423 Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762 871585002424 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 871585002425 trimer interface [polypeptide binding]; other site 871585002426 active site 871585002427 substrate binding site [chemical binding]; other site 871585002428 CoA binding site [chemical binding]; other site 871585002429 rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565 871585002430 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 871585002431 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433 871585002432 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 871585002433 putative active site [active] 871585002434 putative PHP Thumb interface [polypeptide binding]; other site 871585002435 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 871585002436 generic binding surface I; other site 871585002437 generic binding surface II; other site 871585002438 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 871585002439 active site 871585002440 homodimer interface [polypeptide binding]; other site 871585002441 homotetramer interface [polypeptide binding]; other site 871585002442 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 871585002443 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 871585002444 aminotransferase AlaT; Validated; Region: PRK09265 871585002445 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 871585002446 pyridoxal 5'-phosphate binding site [chemical binding]; other site 871585002447 homodimer interface [polypeptide binding]; other site 871585002448 catalytic residue [active] 871585002449 methionine sulfoxide reductase B; Provisional; Region: PRK00222 871585002450 SelR domain; Region: SelR; pfam01641 871585002451 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 871585002452 catalytic residues [active] 871585002453 dimer interface [polypeptide binding]; other site 871585002454 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 871585002455 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 871585002456 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 871585002457 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 871585002458 succinyldiaminopimelate transaminase; Provisional; Region: PRK09147 871585002459 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 871585002460 pyridoxal 5'-phosphate binding site [chemical binding]; other site 871585002461 homodimer interface [polypeptide binding]; other site 871585002462 catalytic residue [active] 871585002463 PII uridylyl-transferase; Provisional; Region: glnD; PRK00275 871585002464 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 871585002465 metal binding triad; other site 871585002466 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 871585002467 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 871585002468 Zn2+ binding site [ion binding]; other site 871585002469 Mg2+ binding site [ion binding]; other site 871585002470 ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900 871585002471 C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899 871585002472 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 871585002473 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 871585002474 ATP-grasp domain; Region: ATP-grasp; pfam02222 871585002475 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 871585002476 active site 1 [active] 871585002477 dimer interface [polypeptide binding]; other site 871585002478 hexamer interface [polypeptide binding]; other site 871585002479 active site 2 [active] 871585002480 putative L-valine exporter; Provisional; Region: PRK10408 871585002481 AzlC protein; Region: AzlC; cl00570 871585002482 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 871585002483 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 871585002484 ligand binding site [chemical binding]; other site 871585002485 flexible hinge region; other site 871585002486 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 871585002487 putative switch regulator; other site 871585002488 non-specific DNA interactions [nucleotide binding]; other site 871585002489 DNA binding site [nucleotide binding] 871585002490 sequence specific DNA binding site [nucleotide binding]; other site 871585002491 putative cAMP binding site [chemical binding]; other site 871585002492 Protein of unknown function (DUF962); Region: DUF962; cl01879 871585002493 GTP-binding protein YchF; Reviewed; Region: PRK09601 871585002494 YchF GTPase; Region: YchF; cd01900 871585002495 G1 box; other site 871585002496 GTP/Mg2+ binding site [chemical binding]; other site 871585002497 Switch I region; other site 871585002498 G2 box; other site 871585002499 Switch II region; other site 871585002500 G3 box; other site 871585002501 G4 box; other site 871585002502 G5 box; other site 871585002503 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 871585002504 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 871585002505 dimer interface [polypeptide binding]; other site 871585002506 conserved gate region; other site 871585002507 ABC-ATPase subunit interface; other site 871585002508 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 871585002509 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 871585002510 Walker A/P-loop; other site 871585002511 ATP binding site [chemical binding]; other site 871585002512 Q-loop/lid; other site 871585002513 ABC transporter signature motif; other site 871585002514 Walker B; other site 871585002515 D-loop; other site 871585002516 H-loop/switch region; other site 871585002517 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 871585002518 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 871585002519 cytoplasmic membrane lipoprotein-28; Provisional; Region: PRK09861 871585002520 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 871585002521 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 871585002522 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 871585002523 active site 871585002524 non-prolyl cis peptide bond; other site 871585002525 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 871585002526 Dibenzothiophene (DBT) desulfurization enzyme C; Region: DszC; cd01163 871585002527 Flavin binding site [chemical binding]; other site 871585002528 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 871585002529 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 871585002530 active site 871585002531 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 871585002532 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 871585002533 C-terminal domain interface [polypeptide binding]; other site 871585002534 GSH binding site (G-site) [chemical binding]; other site 871585002535 dimer interface [polypeptide binding]; other site 871585002536 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 871585002537 N-terminal domain interface [polypeptide binding]; other site 871585002538 glutamate and aspartate transporter subunit; Provisional; Region: PRK10797 871585002539 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 871585002540 substrate binding pocket [chemical binding]; other site 871585002541 membrane-bound complex binding site; other site 871585002542 hinge residues; other site 871585002543 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 871585002544 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 871585002545 dimer interface [polypeptide binding]; other site 871585002546 conserved gate region; other site 871585002547 putative PBP binding loops; other site 871585002548 ABC-ATPase subunit interface; other site 871585002549 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 871585002550 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 871585002551 dimer interface [polypeptide binding]; other site 871585002552 conserved gate region; other site 871585002553 putative PBP binding loops; other site 871585002554 ABC-ATPase subunit interface; other site 871585002555 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 871585002556 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 871585002557 Walker A/P-loop; other site 871585002558 ATP binding site [chemical binding]; other site 871585002559 Q-loop/lid; other site 871585002560 ABC transporter signature motif; other site 871585002561 Walker B; other site 871585002562 D-loop; other site 871585002563 H-loop/switch region; other site 871585002564 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 871585002565 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 871585002566 putative DNA binding site [nucleotide binding]; other site 871585002567 putative Zn2+ binding site [ion binding]; other site 871585002568 AsnC family; Region: AsnC_trans_reg; pfam01037 871585002569 hypothetical protein; Validated; Region: PRK00110 871585002570 potential frameshift: common BLAST hit: gi|299770473|ref|YP_003732499.1| Acyltransferase family protein 871585002571 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 871585002572 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 871585002573 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 871585002574 putative acyl-acceptor binding pocket; other site 871585002575 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 871585002576 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 871585002577 Transcriptional regulator [Transcription]; Region: LysR; COG0583 871585002578 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 871585002579 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 871585002580 dimerization interface [polypeptide binding]; other site 871585002581 Bacterial Transmembrane Pair family; Region: BTP; pfam05232 871585002582 Bacterial Transmembrane Pair family; Region: BTP; pfam05232 871585002583 Purine-cytosine permease and related proteins [Nucleotide transport and metabolism]; Region: CodB; COG1457 871585002584 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 871585002585 Na binding site [ion binding]; other site 871585002586 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 871585002587 EamA-like transporter family; Region: EamA; pfam00892 871585002588 Transcriptional regulator [Transcription]; Region: LysR; COG0583 871585002589 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 871585002590 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 871585002591 dimerization interface [polypeptide binding]; other site 871585002592 putative major fimbrial protein SthE; Provisional; Region: PRK15292 871585002593 Fimbrial protein; Region: Fimbrial; pfam00419 871585002594 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 871585002595 PapC N-terminal domain; Region: PapC_N; pfam13954 871585002596 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 871585002597 PapC C-terminal domain; Region: PapC_C; pfam13953 871585002598 putative chaperone protein EcpD; Provisional; Region: PRK09926 871585002599 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 871585002600 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 871585002601 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 871585002602 biotin synthase; Provisional; Region: PRK15108 871585002603 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 871585002604 FeS/SAM binding site; other site 871585002605 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 871585002606 epoxyqueuosine reductase; Region: TIGR00276 871585002607 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 871585002608 potential frameshift: common BLAST hit: gi|299770454|ref|YP_003732480.1| Carbohydrate kinase family protein 871585002609 YjeF-related protein N-terminus; Region: YjeF_N; pfam03853 871585002610 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 871585002611 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 871585002612 active site 871585002613 putative DNA-binding cleft [nucleotide binding]; other site 871585002614 dimer interface [polypeptide binding]; other site 871585002615 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 871585002616 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 871585002617 non-specific DNA binding site [nucleotide binding]; other site 871585002618 salt bridge; other site 871585002619 sequence-specific DNA binding site [nucleotide binding]; other site 871585002620 Cupin domain; Region: Cupin_2; cl17218 871585002621 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 871585002622 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 871585002623 Coenzyme A binding pocket [chemical binding]; other site 871585002624 Beta-lactamase class D [Defense mechanisms]; Region: COG2602 871585002625 FxsA cytoplasmic membrane protein; Region: FxsA; pfam04186 871585002626 potential frameshift: common BLAST hit: gi|299770446|ref|YP_003732472.1| S-adenosylmethionine synthetase 871585002627 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 871585002628 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 871585002629 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 871585002630 transketolase; Reviewed; Region: PRK12753 871585002631 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 871585002632 TPP-binding site [chemical binding]; other site 871585002633 dimer interface [polypeptide binding]; other site 871585002634 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 871585002635 PYR/PP interface [polypeptide binding]; other site 871585002636 dimer interface [polypeptide binding]; other site 871585002637 TPP binding site [chemical binding]; other site 871585002638 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 871585002639 OsmC-like protein; Region: OsmC; pfam02566 871585002640 Uncharacterized conserved protein [Function unknown]; Region: COG2353 871585002641 Lecithin retinol acyltransferase; Region: LRAT; pfam04970 871585002642 Predicted periplasmic protein [Function unknown]; Region: COG3698 871585002643 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 871585002644 tRNA (uracil-5-)-methyltransferase; Validated; Region: PRK05031 871585002645 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 871585002646 S-adenosylmethionine binding site [chemical binding]; other site 871585002647 Uncharacterized protein family (UPF0157); Region: UPF0157; cl00987 871585002648 bifunctional proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: PRK11905 871585002649 Proline dehydrogenase [Amino acid transport and metabolism]; Region: PutA; COG0506 871585002650 Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125 871585002651 Glutamate binding site [chemical binding]; other site 871585002652 NAD binding site [chemical binding]; other site 871585002653 catalytic residues [active] 871585002654 leucine-responsive transcriptional regulator; Provisional; Region: PRK11169 871585002655 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 871585002656 putative DNA binding site [nucleotide binding]; other site 871585002657 putative Zn2+ binding site [ion binding]; other site 871585002658 AsnC family; Region: AsnC_trans_reg; pfam01037 871585002659 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 871585002660 Na binding site [ion binding]; other site 871585002661 NAD-dependent deacetylase; Provisional; Region: PRK00481 871585002662 SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412 871585002663 NAD+ binding site [chemical binding]; other site 871585002664 substrate binding site [chemical binding]; other site 871585002665 Zn binding site [ion binding]; other site 871585002666 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 871585002667 lipoyl attachment site [posttranslational modification]; other site 871585002668 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 871585002669 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 871585002670 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 871585002671 YdeM is a Bacillus subtilis protein that belongs to a family of prokaryotic proteins of unkown function. YdeM has sequence similarity to the hot-dog fold of (R)-specific enoyl-CoA hydratase. Other enzymes with this fold include the peroxisomal...; Region: YdeM; cd03454 871585002672 putative active site [active] 871585002673 putative catalytic site [active] 871585002674 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 871585002675 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 871585002676 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 871585002677 Walker A/P-loop; other site 871585002678 ATP binding site [chemical binding]; other site 871585002679 Q-loop/lid; other site 871585002680 ABC transporter signature motif; other site 871585002681 Walker B; other site 871585002682 D-loop; other site 871585002683 H-loop/switch region; other site 871585002684 Uncharacterized protein conserved in bacteria (DUF2058); Region: DUF2058; pfam09831 871585002685 Protein of unknown function (DUF1275); Region: DUF1275; pfam06912 871585002686 serine/threonine transporter SstT; Provisional; Region: PRK13628 871585002687 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 871585002688 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 871585002689 dimerization interface [polypeptide binding]; other site 871585002690 putative DNA binding site [nucleotide binding]; other site 871585002691 putative Zn2+ binding site [ion binding]; other site 871585002692 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 871585002693 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 871585002694 Cupin superfamily protein; Region: Cupin_4; pfam08007 871585002695 A domain family that is part of the cupin metalloenzyme superfamily; Region: JmjC; smart00558 871585002696 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 871585002697 Maf-like protein; Region: Maf; pfam02545 871585002698 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 871585002699 active site 871585002700 dimer interface [polypeptide binding]; other site 871585002701 Uncharacterized protein conserved in bacteria (DUF2237); Region: DUF2237; pfam09996 871585002702 phosphoglycerate kinase; Provisional; Region: pgk; PRK00073 871585002703 Phosphoglycerate kinase; Region: PGK; pfam00162 871585002704 substrate binding site [chemical binding]; other site 871585002705 hinge regions; other site 871585002706 ADP binding site [chemical binding]; other site 871585002707 catalytic site [active] 871585002708 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 871585002709 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 871585002710 intersubunit interface [polypeptide binding]; other site 871585002711 active site 871585002712 zinc binding site [ion binding]; other site 871585002713 Na+ binding site [ion binding]; other site 871585002714 peptidyl-prolyl cis-trans isomerase SurA; Provisional; Region: PRK10770 871585002715 SurA N-terminal domain; Region: SurA_N; pfam09312 871585002716 PPIC-type PPIASE domain; Region: Rotamase_2; cl08278 871585002717 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 871585002718 lipopolysaccharide transport periplasmic protein LptA; Region: outer_YhbN_LptA; TIGR03002 871585002719 OstA-like protein; Region: OstA; cl00844 871585002720 Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452 871585002721 Organic solvent tolerance protein; Region: OstA_C; pfam04453 871585002722 Predicted phosphotransferase related to Ser/Thr protein kinases [General function prediction only]; Region: COG3178 871585002723 Phosphotransferase enzyme family; Region: APH; pfam01636 871585002724 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 871585002725 NTP_transferase_like_1 is a member of the nucleotidyl transferase family; Region: NTP_transferase_like_1; cd06422 871585002726 Substrate binding site; other site 871585002727 metal-binding site 871585002728 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 871585002729 rRNA small subunit methyltransferase G; Region: GidB; pfam02527 871585002730 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 871585002731 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 871585002732 P-loop; other site 871585002733 Magnesium ion binding site [ion binding]; other site 871585002734 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 871585002735 Magnesium ion binding site [ion binding]; other site 871585002736 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 871585002737 ParB-like nuclease domain; Region: ParB; smart00470 871585002738 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 871585002739 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 871585002740 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 871585002741 lipid A export permease/ATP-binding protein MsbA; Region: MsbA_lipidA; TIGR02203 871585002742 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 871585002743 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 871585002744 Walker A/P-loop; other site 871585002745 ATP binding site [chemical binding]; other site 871585002746 Q-loop/lid; other site 871585002747 ABC transporter signature motif; other site 871585002748 Walker B; other site 871585002749 D-loop; other site 871585002750 H-loop/switch region; other site 871585002751 Tetraacyldisaccharide-1-P 4'-kinase; Region: LpxK; pfam02606 871585002752 tetraacyldisaccharide 4'-kinase; Region: lpxK; TIGR00682 871585002753 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 871585002754 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 871585002755 Ligand binding site; other site 871585002756 oligomer interface; other site 871585002757 DNA polymerase III subunit delta'; Validated; Region: PRK05707 871585002758 PilZ domain; Region: PilZ; cl01260 871585002759 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 871585002760 active site 871585002761 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 871585002762 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 871585002763 Type II secretion system (T2SS), protein I; Region: T2SI; pfam02501 871585002764 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 871585002765 type II secretion system protein J; Region: gspJ; TIGR01711 871585002766 Type II secretion system (T2SS), protein J; Region: T2SJ; pfam11612 871585002767 Type II secretion system (T2SS), protein K; Region: T2SK; pfam03934 871585002768 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 871585002769 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 871585002770 ligand binding site [chemical binding]; other site 871585002771 active site 871585002772 UGI interface [polypeptide binding]; other site 871585002773 catalytic site [active] 871585002774 3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617 871585002775 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 871585002776 substrate binding site [chemical binding]; other site 871585002777 oxyanion hole (OAH) forming residues; other site 871585002778 trimer interface [polypeptide binding]; other site 871585002779 2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766 871585002780 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 871585002781 nucleoside/Zn binding site; other site 871585002782 dimer interface [polypeptide binding]; other site 871585002783 catalytic motif [active] 871585002784 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 871585002785 putative hydrophobic ligand binding site [chemical binding]; other site 871585002786 protein interface [polypeptide binding]; other site 871585002787 gate; other site 871585002788 cytidylate kinase; Provisional; Region: cmk; PRK00023 871585002789 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 871585002790 CMP-binding site; other site 871585002791 The sites determining sugar specificity; other site 871585002792 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 871585002793 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 871585002794 RNA binding site [nucleotide binding]; other site 871585002795 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 871585002796 RNA binding site [nucleotide binding]; other site 871585002797 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 871585002798 RNA binding site [nucleotide binding]; other site 871585002799 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 871585002800 RNA binding site [nucleotide binding]; other site 871585002801 S1_RPS1_repeat_ec5: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec5; cd05690 871585002802 RNA binding site [nucleotide binding]; other site 871585002803 S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec6; cd05691 871585002804 RNA binding site [nucleotide binding]; other site 871585002805 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 871585002806 IHF dimer interface [polypeptide binding]; other site 871585002807 IHF - DNA interface [nucleotide binding]; other site 871585002808 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 871585002809 active site 871585002810 dimer interface [polypeptide binding]; other site 871585002811 Membrane protein of unknown function (DUF340); Region: DUF340; cl01028 871585002812 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 871585002813 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 871585002814 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 871585002815 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 871585002816 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 871585002817 Predicted ATPase [General function prediction only]; Region: COG1485 871585002818 Malate synthase G (MSG), monomeric enzyme present in some bacteria. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to malyl-CoA , which hydrolyzes to malate and CoA. This reaction is part of the glyoxylate...; Region: malate_synt_G; cd00728 871585002819 active site 871585002820 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 871585002821 Coenzyme A binding pocket [chemical binding]; other site 871585002822 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 871585002823 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 871585002824 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 871585002825 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 871585002826 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 871585002827 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 871585002828 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 871585002829 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 871585002830 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 871585002831 N-terminal plug; other site 871585002832 ligand-binding site [chemical binding]; other site 871585002833 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_18; cd08505 871585002834 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 871585002835 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_18; cd08505 871585002836 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 871585002837 Peptidase M3 Thimet oligopeptidase (TOP) also includes neurolysin; Region: M3A_TOP; cd06455 871585002838 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 871585002839 active site 871585002840 Zn binding site [ion binding]; other site 871585002841 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 871585002842 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 871585002843 dimer interface [polypeptide binding]; other site 871585002844 conserved gate region; other site 871585002845 putative PBP binding loops; other site 871585002846 ABC-ATPase subunit interface; other site 871585002847 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 871585002848 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 871585002849 dimer interface [polypeptide binding]; other site 871585002850 conserved gate region; other site 871585002851 putative PBP binding loops; other site 871585002852 ABC-ATPase subunit interface; other site 871585002853 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 871585002854 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 871585002855 Walker A/P-loop; other site 871585002856 ATP binding site [chemical binding]; other site 871585002857 Q-loop/lid; other site 871585002858 ABC transporter signature motif; other site 871585002859 Walker B; other site 871585002860 D-loop; other site 871585002861 H-loop/switch region; other site 871585002862 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 871585002863 Walker A/P-loop; other site 871585002864 ATP binding site [chemical binding]; other site 871585002865 Q-loop/lid; other site 871585002866 ABC transporter signature motif; other site 871585002867 Walker B; other site 871585002868 D-loop; other site 871585002869 H-loop/switch region; other site 871585002870 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 871585002871 Uncharacterized ACR, COG2135; Region: DUF159; pfam02586 871585002872 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 871585002873 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 871585002874 active site 871585002875 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 871585002876 catalytic core [active] 871585002877 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 871585002878 CC3(TIP30)-like, atypical (a) SDRs; Region: CC3_like_SDR_a; cd05250 871585002879 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 871585002880 NAD binding site [chemical binding]; other site 871585002881 active site 871585002882 ribonuclease activity regulator protein RraA; Provisional; Region: PRK09372 871585002883 GST_N family, 2 repeats of the N-terminal domain of soluble GSTs (2 GST_N) subfamily; composed of uncharacterized proteins. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a...; Region: GST_N_2GST_N; cd03041 871585002884 putative C-terminal domain interface [polypeptide binding]; other site 871585002885 putative GSH binding site (G-site) [chemical binding]; other site 871585002886 putative dimer interface [polypeptide binding]; other site 871585002887 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 871585002888 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 871585002889 Dyp-type peroxidase family; Region: Dyp_perox; cl01067 871585002890 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 871585002891 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 871585002892 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 871585002893 ATP binding site [chemical binding]; other site 871585002894 putative Mg++ binding site [ion binding]; other site 871585002895 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 871585002896 nucleotide binding region [chemical binding]; other site 871585002897 ATP-binding site [chemical binding]; other site 871585002898 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 871585002899 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 871585002900 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 871585002901 cyclase homology domain; Region: CHD; cd07302 871585002902 nucleotidyl binding site; other site 871585002903 metal binding site [ion binding]; metal-binding site 871585002904 dimer interface [polypeptide binding]; other site 871585002905 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 871585002906 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 871585002907 catalytic loop [active] 871585002908 iron binding site [ion binding]; other site 871585002909 chaperone protein HscA; Provisional; Region: hscA; PRK05183 871585002910 Nucleotide-binding domain of HscA and similar proteins; Region: HscA_like_NBD; cd10236 871585002911 nucleotide binding site [chemical binding]; other site 871585002912 putative NEF/HSP70 interaction site [polypeptide binding]; other site 871585002913 SBD interface [polypeptide binding]; other site 871585002914 co-chaperone HscB; Provisional; Region: hscB; PRK05014 871585002915 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 871585002916 HSP70 interaction site [polypeptide binding]; other site 871585002917 HSCB C-terminal oligomerisation domain; Region: HSCB_C; pfam07743 871585002918 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 871585002919 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 871585002920 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 871585002921 trimerization site [polypeptide binding]; other site 871585002922 active site 871585002923 cysteine desulfurase; Provisional; Region: PRK14012 871585002924 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 871585002925 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 871585002926 catalytic residue [active] 871585002927 Transcriptional regulator; Region: Rrf2; cl17282 871585002928 Rrf2 family protein; Region: rrf2_super; TIGR00738 871585002929 Poly(hydroxyalcanoate) granule associated protein (phasin); Region: Phasin; pfam05597 871585002930 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 871585002931 IHF dimer interface [polypeptide binding]; other site 871585002932 IHF - DNA interface [nucleotide binding]; other site 871585002933 periplasmic folding chaperone; Provisional; Region: PRK10788 871585002934 SurA N-terminal domain; Region: SurA_N_3; cl07813 871585002935 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 871585002936 Cupin; Region: Cupin_6; pfam12852 871585002937 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 871585002938 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 871585002939 Alkane hydroxylase is a bacterial, integral-membrane di-iron enzyme that shares a requirement for iron and oxygen for activity similar to that of the non-heme integral-membrane acyl coenzyme A (CoA) desaturases and acyl lipid desaturases. The alk genes...; Region: Alkane-hydroxylase; cd03512 871585002940 Fatty acid desaturase; Region: FA_desaturase; pfam00487 871585002941 Di-iron ligands [ion binding]; other site 871585002942 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 871585002943 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 871585002944 active site 871585002945 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 871585002946 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 871585002947 active site 871585002948 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 871585002949 ABC1 family; Region: ABC1; cl17513 871585002950 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 871585002951 putative deacylase active site [active] 871585002952 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 871585002953 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 871585002954 N-terminal plug; other site 871585002955 ligand-binding site [chemical binding]; other site 871585002956 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 871585002957 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 871585002958 motif II; other site 871585002959 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 871585002960 2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563 871585002961 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 871585002962 homotrimer interface [polypeptide binding]; other site 871585002963 Walker A motif; other site 871585002964 GTP binding site [chemical binding]; other site 871585002965 Walker B motif; other site 871585002966 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 871585002967 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 871585002968 putative dimer interface [polypeptide binding]; other site 871585002969 active site pocket [active] 871585002970 putative cataytic base [active] 871585002971 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 871585002972 catalytic core [active] 871585002973 Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061 871585002974 cobalamin synthase; Reviewed; Region: cobS; PRK00235 871585002975 phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261 871585002976 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 871585002977 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 871585002978 PepSY-associated TM helix; Region: PepSY_TM_3; pfam13706 871585002979 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 871585002980 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 871585002981 Outer membrane receptor for ferric coprogen and ferric-rhodotorulic acid [Inorganic ion transport and metabolism]; Region: FhuE; COG4773 871585002982 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 871585002983 N-terminal plug; other site 871585002984 ligand-binding site [chemical binding]; other site 871585002985 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 871585002986 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 871585002987 Protein of unknown function (DUF2797); Region: DUF2797; pfam10977 871585002988 Bacterial protein of unknown function (DUF937); Region: DUF937; cl01528 871585002989 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 871585002990 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 871585002991 eyelet of channel; other site 871585002992 trimer interface [polypeptide binding]; other site 871585002993 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 871585002994 HIT family signature motif; other site 871585002995 catalytic residue [active] 871585002996 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 871585002997 Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167 871585002998 O-succinylhomoserine sulfhydrylase; Validated; Region: PRK08133 871585002999 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 871585003000 homodimer interface [polypeptide binding]; other site 871585003001 substrate-cofactor binding pocket; other site 871585003002 pyridoxal 5'-phosphate binding site [chemical binding]; other site 871585003003 catalytic residue [active] 871585003004 hypothetical protein; Validated; Region: PRK00153 871585003005 recombination protein RecR; Reviewed; Region: recR; PRK00076 871585003006 RecR protein; Region: RecR; pfam02132 871585003007 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 871585003008 putative active site [active] 871585003009 putative metal-binding site [ion binding]; other site 871585003010 tetramer interface [polypeptide binding]; other site 871585003011 Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349 871585003012 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 871585003013 catalytic site [active] 871585003014 putative active site [active] 871585003015 putative substrate binding site [chemical binding]; other site 871585003016 HRDC domain; Region: HRDC; pfam00570 871585003017 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 871585003018 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 871585003019 Transcriptional regulator [Transcription]; Region: LysR; COG0583 871585003020 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 871585003021 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 871585003022 dimerization interface [polypeptide binding]; other site 871585003023 YcgL domain; Region: YcgL; cl01189 871585003024 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 871585003025 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 871585003026 Walker A motif; other site 871585003027 ATP binding site [chemical binding]; other site 871585003028 Walker B motif; other site 871585003029 arginine finger; other site 871585003030 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3825 871585003031 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 871585003032 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 871585003033 pyridoxal 5'-phosphate binding site [chemical binding]; other site 871585003034 catalytic residue [active] 871585003035 HemK family putative methylases; Region: hemK_fam; TIGR00536 871585003036 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 871585003037 S-adenosylmethionine binding site [chemical binding]; other site 871585003038 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 871585003039 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 871585003040 Tetramer interface [polypeptide binding]; other site 871585003041 active site 871585003042 FMN-binding site [chemical binding]; other site 871585003043 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 871585003044 metal binding site [ion binding]; metal-binding site 871585003045 active site 871585003046 I-site; other site 871585003047 TENA/THI-4/PQQC family; Region: TENA_THI-4; cl15243 871585003048 DNA-binding transcriptional regulator DhaR; Provisional; Region: PRK11388 871585003049 lipoyl synthase; Provisional; Region: PRK12928 871585003050 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 871585003051 FeS/SAM binding site; other site 871585003052 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182 871585003053 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 871585003054 tetramer interface [polypeptide binding]; other site 871585003055 TPP-binding site [chemical binding]; other site 871585003056 heterodimer interface [polypeptide binding]; other site 871585003057 phosphorylation loop region [posttranslational modification] 871585003058 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 871585003059 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 871585003060 alpha subunit interface [polypeptide binding]; other site 871585003061 TPP binding site [chemical binding]; other site 871585003062 heterodimer interface [polypeptide binding]; other site 871585003063 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 871585003064 pyruvate dehydrogenase complex dihydrolipoamide acetyltransferase, long form; Region: PDHac_trf_mito; TIGR01349 871585003065 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 871585003066 E3 interaction surface; other site 871585003067 lipoyl attachment site [posttranslational modification]; other site 871585003068 e3 binding domain; Region: E3_binding; pfam02817 871585003069 e3 binding domain; Region: E3_binding; pfam02817 871585003070 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 871585003071 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 871585003072 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 871585003073 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 871585003074 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 871585003075 meso-2,3-butanediol dehydrogenase-like, classical (c) SDRs; Region: meso-BDH-like_SDR_c; cd05366 871585003076 acetoin reductases; Region: 23BDH; TIGR02415 871585003077 NAD binding site [chemical binding]; other site 871585003078 homotetramer interface [polypeptide binding]; other site 871585003079 homodimer interface [polypeptide binding]; other site 871585003080 active site 871585003081 substrate binding site [chemical binding]; other site 871585003082 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 871585003083 (2R,3R)-2,3-butanediol dehydrogenase; Region: butanediol_DH_like; cd08233 871585003084 putative NAD(P) binding site [chemical binding]; other site 871585003085 catalytic Zn binding site [ion binding]; other site 871585003086 Bestrophin, RFP-TM, chloride channel; Region: Bestrophin; pfam01062 871585003087 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 871585003088 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 871585003089 Walker A motif; other site 871585003090 ATP binding site [chemical binding]; other site 871585003091 Walker B motif; other site 871585003092 arginine finger; other site 871585003093 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 871585003094 potential frameshift: common BLAST hit: gi|184158064|ref|YP_001846403.1| NAD(FAD)-dependent dehydrogenase 871585003095 Putative phosphatase (DUF442); Region: DUF442; cl17385 871585003096 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 871585003097 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 871585003098 homoserine dehydrogenase; Validated; Region: PRK06813 871585003099 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 871585003100 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 871585003101 EamA-like transporter family; Region: EamA; pfam00892 871585003102 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 871585003103 EamA-like transporter family; Region: EamA; pfam00892 871585003104 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 871585003105 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 871585003106 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 871585003107 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 871585003108 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 871585003109 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 871585003110 Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059 871585003111 chromate transporter, chromate ion transporter (CHR) family; Region: 2A51; TIGR00937 871585003112 Chromate transporter; Region: Chromate_transp; pfam02417 871585003113 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 871585003114 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 871585003115 DNA-binding site [nucleotide binding]; DNA binding site 871585003116 UTRA domain; Region: UTRA; pfam07702 871585003117 putative oxidoreductase; Provisional; Region: PRK08275 871585003118 L-aspartate oxidase; Provisional; Region: PRK06175 871585003119 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 871585003120 Ferredoxin [Energy production and conversion]; Region: COG1146 871585003121 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 871585003122 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 871585003123 substrate binding pocket [chemical binding]; other site 871585003124 membrane-bound complex binding site; other site 871585003125 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 871585003126 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 871585003127 dimer interface [polypeptide binding]; other site 871585003128 conserved gate region; other site 871585003129 putative PBP binding loops; other site 871585003130 ABC-ATPase subunit interface; other site 871585003131 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 871585003132 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 871585003133 Walker A/P-loop; other site 871585003134 ATP binding site [chemical binding]; other site 871585003135 Q-loop/lid; other site 871585003136 ABC transporter signature motif; other site 871585003137 Walker B; other site 871585003138 D-loop; other site 871585003139 H-loop/switch region; other site 871585003140 HEAT repeats; Region: HEAT_2; pfam13646 871585003141 HEAT repeats; Region: HEAT_2; pfam13646 871585003142 HEAT repeats; Region: HEAT_2; pfam13646 871585003143 HEAT repeats; Region: HEAT_2; pfam13646 871585003144 Protein of unknown function (DUF971); Region: DUF971; cl01414 871585003145 alpha-ketoglutarate transporter; Provisional; Region: PRK10406 871585003146 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 871585003147 putative substrate translocation pore; other site 871585003148 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 871585003149 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 871585003150 N-terminal plug; other site 871585003151 ligand-binding site [chemical binding]; other site 871585003152 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 871585003153 Aspartase; Region: Aspartase; cd01357 871585003154 active sites [active] 871585003155 tetramer interface [polypeptide binding]; other site 871585003156 SurA N-terminal domain; Region: SurA_N_3; cl07813 871585003157 cell density-dependent motility repressor; Provisional; Region: PRK10082 871585003158 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 871585003159 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 871585003160 dimerization interface [polypeptide binding]; other site 871585003161 Transcriptional regulator [Transcription]; Region: LysR; COG0583 871585003162 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 871585003163 The C-terminal substrate binding domain of LysR-type transcriptional regulators that are involved in the catabolism of dinitrotoluene, naphthalene and gamma-hexachlorohexane; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_NahR_LinR_like; cd08459 871585003164 substrate binding pocket [chemical binding]; other site 871585003165 dimerization interface [polypeptide binding]; other site 871585003166 acetyl-CoA acetyltransferase; Provisional; Region: PRK06954 871585003167 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 871585003168 dimer interface [polypeptide binding]; other site 871585003169 active site 871585003170 Short chain fatty acids transporter [Lipid metabolism]; Region: AtoE; COG2031 871585003171 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 871585003172 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 871585003173 Transcriptional regulator [Transcription]; Region: LysR; COG0583 871585003174 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 871585003175 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 871585003176 putative dimerization interface [polypeptide binding]; other site 871585003177 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 871585003178 fructuronate transporter; Provisional; Region: PRK10034; cl15264 871585003179 3-hydroxybutyrate dehydrogenase; Provisional; Region: PRK12429 871585003180 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 871585003181 NAD(P) binding site [chemical binding]; other site 871585003182 active site 871585003183 Helix-turn-helix domain; Region: HTH_18; pfam12833 871585003184 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 871585003185 benzoate transport; Region: 2A0115; TIGR00895 871585003186 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 871585003187 putative substrate translocation pore; other site 871585003188 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 871585003189 outer membrane porin, OprD family; Region: OprD; pfam03573 871585003190 Dienelactone hydrolase family; Region: DLH; pfam01738 871585003191 SnoaL-like domain; Region: SnoaL_2; pfam12680 871585003192 short chain dehydrogenase; Provisional; Region: PRK08265 871585003193 classical (c) SDRs; Region: SDR_c; cd05233 871585003194 NAD(P) binding site [chemical binding]; other site 871585003195 active site 871585003196 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 871585003197 Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; cl01768 871585003198 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 871585003199 Helix-turn-helix domain; Region: HTH_18; pfam12833 871585003200 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 871585003201 anthranilate dioxygenase reductase; Provisional; Region: antC; PRK11872 871585003202 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 871585003203 catalytic loop [active] 871585003204 iron binding site [ion binding]; other site 871585003205 Benzoate dioxygenase reductase (BenDO) FAD/NAD binding domain. Oxygenases oxidize hydrocarbons using dioxygen as the oxidant. As a Class I bacterial dioxygenases, benzoate dioxygenase like proteins combine an [2Fe-2S] cluster containing N-terminal...; Region: BenDO_FAD_NAD; cd06209 871585003206 FAD binding pocket [chemical binding]; other site 871585003207 FAD binding motif [chemical binding]; other site 871585003208 phosphate binding motif [ion binding]; other site 871585003209 beta-alpha-beta structure motif; other site 871585003210 NAD binding pocket [chemical binding]; other site 871585003211 Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667 871585003212 inter-subunit interface; other site 871585003213 anthranilate 1,2-dioxygenase, large subunit; Region: anthran_1_2_A; TIGR03228 871585003214 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 871585003215 [2Fe-2S] cluster binding site [ion binding]; other site 871585003216 C-terminal catalytic domain of the oxygenase alpha subunit of Pseudomonas resinovorans strain CA10 anthranilate 1,2-dioxygenase and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_AntDO-like; cd08879 871585003217 putative alpha subunit interface [polypeptide binding]; other site 871585003218 putative active site [active] 871585003219 putative substrate binding site [chemical binding]; other site 871585003220 Fe binding site [ion binding]; other site 871585003221 N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; cl17549 871585003222 molybdate transporter periplasmic protein; Provisional; Region: modA; PRK10677 871585003223 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 871585003224 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 871585003225 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 871585003226 dimer interface [polypeptide binding]; other site 871585003227 conserved gate region; other site 871585003228 putative PBP binding loops; other site 871585003229 ABC-ATPase subunit interface; other site 871585003230 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 871585003231 Walker A/P-loop; other site 871585003232 ATP binding site [chemical binding]; other site 871585003233 Q-loop/lid; other site 871585003234 ABC transporter signature motif; other site 871585003235 Walker B; other site 871585003236 D-loop; other site 871585003237 H-loop/switch region; other site 871585003238 2,3-dihydroxybenzoate-2,3-dehydrogenase; Validated; Region: PRK08220 871585003239 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 871585003240 NAD(P) binding site [chemical binding]; other site 871585003241 active site 871585003242 Isochorismatase, also known as 2,3 dihydro-2,3 dihydroxybenzoate synthase, catalyses the conversion of isochorismate, in the presence of water, to 2,3-dihydroxybenzoate and pyruvate, via the hydrolysis of a vinyl ether, an uncommon reaction in biological...; Region: isochorismatase; cd01013 871585003243 hydrophobic substrate binding pocket; other site 871585003244 Isochorismatase family; Region: Isochorismatase; pfam00857 871585003245 active site 871585003246 conserved cis-peptide bond; other site 871585003247 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cl17326 871585003248 metal binding site 2 [ion binding]; metal-binding site 871585003249 putative DNA binding helix; other site 871585003250 metal binding site 1 [ion binding]; metal-binding site 871585003251 dimer interface [polypeptide binding]; other site 871585003252 structural Zn2+ binding site [ion binding]; other site 871585003253 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 871585003254 Bacillus subtilis YhcR endonuclease and related proteins, N-terminal metallophosphatase domain; Region: MPP_YhcR_N; cd07412 871585003255 putative active site [active] 871585003256 putative metal binding site [ion binding]; other site 871585003257 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 871585003258 pyrroloquinoline quinone biosynthesis protein PqqB; Provisional; Region: PRK05184 871585003259 coenzyme PQQ biosynthesis protein B; Region: PQQ_syn_pqqB; TIGR02108 871585003260 pyrroloquinoline quinone biosynthesis protein PqqC; Provisional; Region: PRK05157 871585003261 pyrroloquinoline quinone biosynthesis protein PqqD; Provisional; Region: PRK02079 871585003262 pyrroloquinoline quinone biosynthesis protein PqqE; Provisional; Region: PRK05301 871585003263 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 871585003264 FeS/SAM binding site; other site 871585003265 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 871585003266 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 871585003267 renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301 871585003268 active site 871585003269 dimer interface [polypeptide binding]; other site 871585003270 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 871585003271 Protein export membrane protein; Region: SecD_SecF; cl14618 871585003272 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 871585003273 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 871585003274 HlyD family secretion protein; Region: HlyD_3; pfam13437 871585003275 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 871585003276 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 871585003277 active site 871585003278 phosphorylation site [posttranslational modification] 871585003279 intermolecular recognition site; other site 871585003280 dimerization interface [polypeptide binding]; other site 871585003281 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 871585003282 DNA binding site [nucleotide binding] 871585003283 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 871585003284 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 871585003285 dimerization interface [polypeptide binding]; other site 871585003286 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 871585003287 dimer interface [polypeptide binding]; other site 871585003288 phosphorylation site [posttranslational modification] 871585003289 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 871585003290 ATP binding site [chemical binding]; other site 871585003291 Mg2+ binding site [ion binding]; other site 871585003292 G-X-G motif; other site 871585003293 MUG-like Uracil-DNA glycosylase enzyme family; Region: UDG_MUG_like; cd10032 871585003294 putative active site [active] 871585003295 Putative catalytic domain, repeat 1, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_1; cd09111 871585003296 PLD-like domain; Region: PLDc_2; pfam13091 871585003297 putative active site [active] 871585003298 catalytic site [active] 871585003299 Putative catalytic domain, repeat 2, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_2; cd09113 871585003300 PLD-like domain; Region: PLDc_2; pfam13091 871585003301 putative active site [active] 871585003302 catalytic site [active] 871585003303 Uncharacterized conserved protein [Function unknown]; Region: COG3791 871585003304 Catalase-like heme-binding proteins similar to the uncharacterized y4iL; Region: y4iL_like; cd08152 871585003305 putative heme binding pocket [chemical binding]; other site 871585003306 class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300 871585003307 S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase; Region: adh_III_F_hyde; TIGR02818 871585003308 substrate binding site [chemical binding]; other site 871585003309 catalytic Zn binding site [ion binding]; other site 871585003310 NAD binding site [chemical binding]; other site 871585003311 structural Zn binding site [ion binding]; other site 871585003312 dimer interface [polypeptide binding]; other site 871585003313 putative major fimbrial protein SthE; Provisional; Region: PRK15292 871585003314 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 871585003315 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 871585003316 PapC N-terminal domain; Region: PapC_N; pfam13954 871585003317 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 871585003318 PapC C-terminal domain; Region: PapC_C; pfam13953 871585003319 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 871585003320 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 871585003321 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 871585003322 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 871585003323 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 871585003324 Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; pfam00596 871585003325 active site 871585003326 Zn2+ binding site [ion binding]; other site 871585003327 intersubunit interface [polypeptide binding]; other site 871585003328 alkanesulfonate monooxygenase; Provisional; Region: PRK00719 871585003329 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 871585003330 active site 871585003331 dimer interface [polypeptide binding]; other site 871585003332 non-prolyl cis peptide bond; other site 871585003333 insertion regions; other site 871585003334 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_17; cd08503 871585003335 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 871585003336 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 871585003337 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 871585003338 dimer interface [polypeptide binding]; other site 871585003339 conserved gate region; other site 871585003340 putative PBP binding loops; other site 871585003341 ABC-ATPase subunit interface; other site 871585003342 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 871585003343 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 871585003344 dimer interface [polypeptide binding]; other site 871585003345 conserved gate region; other site 871585003346 putative PBP binding loops; other site 871585003347 ABC-ATPase subunit interface; other site 871585003348 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 871585003349 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 871585003350 Walker A/P-loop; other site 871585003351 ATP binding site [chemical binding]; other site 871585003352 Q-loop/lid; other site 871585003353 ABC transporter signature motif; other site 871585003354 Walker B; other site 871585003355 D-loop; other site 871585003356 H-loop/switch region; other site 871585003357 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 871585003358 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 871585003359 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 871585003360 Walker A/P-loop; other site 871585003361 ATP binding site [chemical binding]; other site 871585003362 Q-loop/lid; other site 871585003363 ABC transporter signature motif; other site 871585003364 Walker B; other site 871585003365 D-loop; other site 871585003366 H-loop/switch region; other site 871585003367 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 871585003368 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 871585003369 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 871585003370 active site 871585003371 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 871585003372 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 871585003373 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 871585003374 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 871585003375 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 871585003376 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 871585003377 Walker A/P-loop; other site 871585003378 ATP binding site [chemical binding]; other site 871585003379 Q-loop/lid; other site 871585003380 ABC transporter signature motif; other site 871585003381 Walker B; other site 871585003382 D-loop; other site 871585003383 H-loop/switch region; other site 871585003384 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 871585003385 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 871585003386 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 871585003387 Walker A/P-loop; other site 871585003388 ATP binding site [chemical binding]; other site 871585003389 Q-loop/lid; other site 871585003390 ABC transporter signature motif; other site 871585003391 Walker B; other site 871585003392 D-loop; other site 871585003393 H-loop/switch region; other site 871585003394 Outer membrane receptor for ferrienterochelin and colicins [Inorganic ion transport and metabolism]; Region: FepA; COG4771 871585003395 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 871585003396 N-terminal plug; other site 871585003397 ligand-binding site [chemical binding]; other site 871585003398 Secretory lipase; Region: LIP; pfam03583 871585003399 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 871585003400 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 871585003401 dimer interface [polypeptide binding]; other site 871585003402 active site 871585003403 non-prolyl cis peptide bond; other site 871585003404 insertion regions; other site 871585003405 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 871585003406 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 871585003407 Walker A motif; other site 871585003408 ATP binding site [chemical binding]; other site 871585003409 Walker B motif; other site 871585003410 arginine finger; other site 871585003411 Sec-independent protein translocase protein (TatC); Region: TatC; cl00521 871585003412 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 871585003413 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 871585003414 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 871585003415 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 871585003416 Walker A/P-loop; other site 871585003417 ATP binding site [chemical binding]; other site 871585003418 Q-loop/lid; other site 871585003419 ABC transporter signature motif; other site 871585003420 Walker B; other site 871585003421 D-loop; other site 871585003422 H-loop/switch region; other site 871585003423 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 871585003424 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 871585003425 dimer interface [polypeptide binding]; other site 871585003426 conserved gate region; other site 871585003427 ABC-ATPase subunit interface; other site 871585003428 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 871585003429 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 871585003430 NMT1/THI5 like; Region: NMT1; pfam09084 871585003431 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 871585003432 membrane-bound complex binding site; other site 871585003433 alkanesulfonate monooxygenase, FMNH(2)-dependent; Region: alk_sulf_monoox; TIGR03565 871585003434 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 871585003435 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 871585003436 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 871585003437 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 871585003438 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 871585003439 TolR protein; Region: tolR; TIGR02801 871585003440 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_17; cd08503 871585003441 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 871585003442 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 871585003443 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 871585003444 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 871585003445 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 871585003446 N-terminal plug; other site 871585003447 ligand-binding site [chemical binding]; other site 871585003448 alkanesulfonate monooxygenase, FMNH(2)-dependent; Region: alk_sulf_monoox; TIGR03565 871585003449 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 871585003450 active site 871585003451 dimer interface [polypeptide binding]; other site 871585003452 non-prolyl cis peptide bond; other site 871585003453 insertion regions; other site 871585003454 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 871585003455 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 871585003456 dimer interface [polypeptide binding]; other site 871585003457 conserved gate region; other site 871585003458 putative PBP binding loops; other site 871585003459 ABC-ATPase subunit interface; other site 871585003460 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 871585003461 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 871585003462 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 871585003463 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 871585003464 Walker A/P-loop; other site 871585003465 ATP binding site [chemical binding]; other site 871585003466 Q-loop/lid; other site 871585003467 ABC transporter signature motif; other site 871585003468 Walker B; other site 871585003469 D-loop; other site 871585003470 H-loop/switch region; other site 871585003471 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 871585003472 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 871585003473 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 871585003474 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 871585003475 TolR protein; Region: tolR; TIGR02801 871585003476 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 871585003477 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 871585003478 ligand binding site [chemical binding]; other site 871585003479 flexible hinge region; other site 871585003480 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 871585003481 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 871585003482 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 871585003483 active site 871585003484 iron coordination sites [ion binding]; other site 871585003485 substrate binding pocket [chemical binding]; other site 871585003486 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 871585003487 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 871585003488 substrate binding pocket [chemical binding]; other site 871585003489 membrane-bound complex binding site; other site 871585003490 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 871585003491 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 871585003492 N-terminal plug; other site 871585003493 ligand-binding site [chemical binding]; other site 871585003494 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 871585003495 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 871585003496 active site 871585003497 non-prolyl cis peptide bond; other site 871585003498 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 871585003499 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 871585003500 active site 871585003501 catalytic tetrad [active] 871585003502 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 871585003503 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 871585003504 N-terminal plug; other site 871585003505 ligand-binding site [chemical binding]; other site 871585003506 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 871585003507 Sulfatase; Region: Sulfatase; pfam00884 871585003508 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 871585003509 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 871585003510 ligand binding site [chemical binding]; other site 871585003511 flexible hinge region; other site 871585003512 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 871585003513 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 871585003514 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 871585003515 active site 871585003516 iron coordination sites [ion binding]; other site 871585003517 substrate binding pocket [chemical binding]; other site 871585003518 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 871585003519 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 871585003520 TnsA endonuclease N terminal; Region: Tn7_Tnp_TnsA_N; pfam08722 871585003521 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: HsdR; COG4096 871585003522 Type III restriction enzyme, res subunit; Region: ResIII; pfam04851 871585003523 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 871585003524 nucleotide binding region [chemical binding]; other site 871585003525 ATP-binding site [chemical binding]; other site 871585003526 EcoEI R protein C-terminal; Region: EcoEI_R_C; pfam08463 871585003527 Methyltransferase domain; Region: Methyltransf_26; pfam13659 871585003528 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 871585003529 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1672 871585003530 AAA ATPase domain; Region: AAA_16; pfam13191 871585003531 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 871585003532 Walker A motif; other site 871585003533 ATP binding site [chemical binding]; other site 871585003534 Walker B motif; other site 871585003535 haemagglutination activity domain; Region: Haemagg_act; pfam05860 871585003536 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 871585003537 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 871585003538 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 871585003539 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 871585003540 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 871585003541 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 871585003542 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 871585003543 Haemolysin secretion/activation protein ShlB/FhaC/HecB; Region: ShlB; pfam03865 871585003544 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 871585003545 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 871585003546 dimerization interface [polypeptide binding]; other site 871585003547 putative DNA binding site [nucleotide binding]; other site 871585003548 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 871585003549 putative Zn2+ binding site [ion binding]; other site 871585003550 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 871585003551 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 871585003552 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 871585003553 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 871585003554 classical (c) SDRs; Region: SDR_c; cd05233 871585003555 NAD(P) binding site [chemical binding]; other site 871585003556 active site 871585003557 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 871585003558 classical (c) SDRs; Region: SDR_c; cd05233 871585003559 NAD(P) binding site [chemical binding]; other site 871585003560 active site 871585003561 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 871585003562 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 871585003563 putative substrate translocation pore; other site 871585003564 potential frameshift: common BLAST hit: gi|299770117|ref|YP_003732143.1| putative acyl-CoA transferase/carnitine dehydratase 871585003565 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 871585003566 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 871585003567 CoA-transferase family III; Region: CoA_transf_3; pfam02515 871585003568 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 871585003569 active site 871585003570 catalytic residues [active] 871585003571 metal binding site [ion binding]; metal-binding site 871585003572 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 871585003573 Strictosidine synthase; Region: Str_synth; pfam03088 871585003574 H+/citrate symporter [Energy production and conversion]; Region: CitM; COG2851 871585003575 Citrate transporter; Region: CitMHS; pfam03600 871585003576 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 871585003577 Transcriptional regulator [Transcription]; Region: IclR; COG1414 871585003578 Bacterial transcriptional regulator; Region: IclR; pfam01614 871585003579 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 871585003580 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788 871585003581 catalytic residues [active] 871585003582 catalytic nucleophile [active] 871585003583 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 871585003584 DNA-binding interface [nucleotide binding]; DNA binding site 871585003585 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 871585003586 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 871585003587 putative DNA binding site [nucleotide binding]; other site 871585003588 putative Zn2+ binding site [ion binding]; other site 871585003589 AsnC family; Region: AsnC_trans_reg; pfam01037 871585003590 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 871585003591 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 871585003592 Sel1-like repeats; Region: SEL1; smart00671 871585003593 Sel1-like repeats; Region: SEL1; smart00671 871585003594 Sel1-like repeats; Region: SEL1; smart00671 871585003595 Sel1-like repeats; Region: SEL1; smart00671 871585003596 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 871585003597 Coenzyme A binding pocket [chemical binding]; other site 871585003598 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 871585003599 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 871585003600 HD domain; Region: HD_4; pfam13328 871585003601 Survival protein SurE; Region: SurE; pfam01975 871585003602 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 871585003603 GH3 auxin-responsive promoter; Region: GH3; pfam03321 871585003604 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 871585003605 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 871585003606 putative substrate translocation pore; other site 871585003607 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 871585003608 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 871585003609 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 871585003610 HlyD family secretion protein; Region: HlyD_3; pfam13437 871585003611 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cl00246 871585003612 FAD binding site [chemical binding]; other site 871585003613 Methylene-tetrahydrofolate reductase C terminal; Region: MTHFR_C; pfam12225 871585003614 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 871585003615 nudix motif; other site 871585003616 Uncharacterized conserved protein [General function prediction only]; Region: COG4111 871585003617 putative nicotinate phosphoribosyltransferase; Provisional; Region: PRK09198 871585003618 pre-B-cell colony-enhancing factor (PBEF)-like. The mammalian members of this group of nicotinate phosphoribosyltransferases (NAPRTases) were originally identified as genes whose expression is upregulated upon activation in lymphoid cells. In general; Region: PBEF_like; cd01569 871585003619 active site 871585003620 Phosphoribosylpyrophosphate synthetase [Nucleotide transport and metabolism / Amino acid transport and metabolism]; Region: PrsA; COG0462 871585003621 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 871585003622 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 871585003623 active site 871585003624 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 871585003625 Cupin domain; Region: Cupin_2; cl17218 871585003626 Helix-turn-helix domain; Region: HTH_18; pfam12833 871585003627 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 871585003628 Coenzyme A binding pocket [chemical binding]; other site 871585003629 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 871585003630 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 871585003631 Walker A/P-loop; other site 871585003632 ATP binding site [chemical binding]; other site 871585003633 Q-loop/lid; other site 871585003634 ABC transporter signature motif; other site 871585003635 Walker B; other site 871585003636 D-loop; other site 871585003637 H-loop/switch region; other site 871585003638 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 871585003639 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 871585003640 ABC-ATPase subunit interface; other site 871585003641 dimer interface [polypeptide binding]; other site 871585003642 putative PBP binding regions; other site 871585003643 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 871585003644 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 871585003645 intersubunit interface [polypeptide binding]; other site 871585003646 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 871585003647 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 871585003648 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 871585003649 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 871585003650 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 871585003651 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 871585003652 putative substrate translocation pore; other site 871585003653 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 871585003654 Escherichia coli Gne (a nucleoside-diphosphate-sugar 4-epimerase)-like, extended (e) SDRs; Region: Gne_like_SDR_e; cd05238 871585003655 putative NAD(P) binding site [chemical binding]; other site 871585003656 active site 871585003657 putative substrate binding site [chemical binding]; other site 871585003658 potential frameshift: common BLAST hit: gi|184158204|ref|YP_001846543.1| transcriptional regulator 871585003659 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 871585003660 Transcriptional regulator [Transcription]; Region: LysR; COG0583 871585003661 Transcriptional regulator [Transcription]; Region: LysR; COG0583 871585003662 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 871585003663 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 871585003664 dimerization interface [polypeptide binding]; other site 871585003665 Fumarylacetoacetate (FAA) hydrolase family protein [General function prediction only]; Region: COG3970 871585003666 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 871585003667 potential frameshift: common BLAST hit: gi|299770066|ref|YP_003732092.1| dihydroxy-acid dehydratase 871585003668 Dehydratase family; Region: ILVD_EDD; cl00340 871585003669 Dehydratase family; Region: ILVD_EDD; cl00340 871585003670 potential frameshift: common BLAST hit: gi|215483357|ref|YP_002325568.1| NADP-dependent fatty aldehyde dehydrogenase 871585003671 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 871585003672 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 871585003673 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 871585003674 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 871585003675 Alpha-Ketoglutaric Semialdehyde Dehydrogenase; Region: ALDH_KGSADH; cd07129 871585003676 dimer interface [polypeptide binding]; other site 871585003677 NADP binding site [chemical binding]; other site 871585003678 catalytic residues [active] 871585003679 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 871585003680 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 871585003681 AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246 871585003682 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 871585003683 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 871585003684 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 871585003685 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 871585003686 E3 interaction surface; other site 871585003687 lipoyl attachment site [posttranslational modification]; other site 871585003688 HlyD family secretion protein; Region: HlyD_3; pfam13437 871585003689 gamma-aminobutyrate permease; Region: GABAperm; TIGR01773 871585003690 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 871585003691 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 871585003692 tetrameric interface [polypeptide binding]; other site 871585003693 NAD binding site [chemical binding]; other site 871585003694 catalytic residues [active] 871585003695 beta alanine--pyruvate transaminase; Provisional; Region: PRK09221 871585003696 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 871585003697 inhibitor-cofactor binding pocket; inhibition site 871585003698 pyridoxal 5'-phosphate binding site [chemical binding]; other site 871585003699 catalytic residue [active] 871585003700 Transcriptional regulator [Transcription]; Region: LysR; COG0583 871585003701 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 871585003702 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 871585003703 dimerization interface [polypeptide binding]; other site 871585003704 haemagglutination activity domain; Region: Haemagg_act; pfam05860 871585003705 Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; cl01733 871585003706 Possible hemagglutinin (DUF637); Region: DUF637; pfam04830 871585003707 Pre-toxin domain with VENN motif; Region: PT-VENN; pfam04829 871585003708 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 871585003709 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 871585003710 Haemolysin secretion/activation protein ShlB/FhaC/HecB; Region: ShlB; pfam03865 871585003711 type I secretion C-terminal target domain (VC_A0849 subclass); Region: T1SS_VCA0849; TIGR03661 871585003712 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 871585003713 Antitoxin of toxin-antitoxin stability system N-terminal; Region: RelB_N; pfam12910 871585003714 hypothetical protein; Validated; Region: PRK06201 871585003715 hypothetical protein; Validated; Region: PRK06201 871585003716 Demethylmenaquinone methyltransferase [Coenzyme metabolism]; Region: MenG; COG0684 871585003717 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 871585003718 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 871585003719 ligand binding site [chemical binding]; other site 871585003720 NAD binding site [chemical binding]; other site 871585003721 dimerization interface [polypeptide binding]; other site 871585003722 catalytic site [active] 871585003723 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 871585003724 putative substrate translocation pore; other site 871585003725 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 871585003726 Transcriptional regulator [Transcription]; Region: IclR; COG1414 871585003727 Bacterial transcriptional regulator; Region: IclR; pfam01614 871585003728 Protein of unknown function, DUF606; Region: DUF606; pfam04657 871585003729 Protein of unknown function, DUF606; Region: DUF606; pfam04657 871585003730 Transcriptional regulator [Transcription]; Region: LysR; COG0583 871585003731 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 871585003732 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 871585003733 putative effector binding pocket; other site 871585003734 dimerization interface [polypeptide binding]; other site 871585003735 Uncharacterized protein conserved in bacteria (DUF2314); Region: DUF2314; pfam10077 871585003736 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3779 871585003737 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 871585003738 PAAR motif; Region: PAAR_motif; pfam05488 871585003739 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 871585003740 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 871585003741 bile acid transporter; Region: bass; TIGR00841 871585003742 Sodium Bile acid symporter family; Region: SBF; pfam01758 871585003743 Long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07059 871585003744 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 871585003745 acyl-activating enzyme (AAE) consensus motif; other site 871585003746 putative AMP binding site [chemical binding]; other site 871585003747 putative active site [active] 871585003748 putative CoA binding site [chemical binding]; other site 871585003749 Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; cl17479 871585003750 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 871585003751 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 871585003752 active site 871585003753 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 871585003754 NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450 871585003755 putative active site [active] 871585003756 putative catalytic site [active] 871585003757 (3R)-hydroxyacyl-CoA dehydrogenase-like, classical(c)-like SDRs; Region: hydroxyacyl-CoA-like_DH_SDR_c-like; cd05353 871585003758 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK12825 871585003759 NAD binding site [chemical binding]; other site 871585003760 homodimer interface [polypeptide binding]; other site 871585003761 active site 871585003762 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 871585003763 classical (c) SDRs; Region: SDR_c; cd05233 871585003764 NAD(P) binding site [chemical binding]; other site 871585003765 active site 871585003766 short chain dehydrogenase; Provisional; Region: PRK07035 871585003767 classical (c) SDRs; Region: SDR_c; cd05233 871585003768 NAD(P) binding site [chemical binding]; other site 871585003769 active site 871585003770 Transcriptional regulator [Transcription]; Region: LysR; COG0583 871585003771 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 871585003772 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 871585003773 substrate binding pocket [chemical binding]; other site 871585003774 dimerization interface [polypeptide binding]; other site 871585003775 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 871585003776 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 871585003777 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 871585003778 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 871585003779 Transcriptional regulator; Region: Rrf2; pfam02082 871585003780 Predicted transcriptional regulator [Transcription]; Region: COG1959 871585003781 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 871585003782 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 871585003783 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 871585003784 potential catalytic triad [active] 871585003785 conserved cys residue [active] 871585003786 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 871585003787 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 871585003788 DNA binding residues [nucleotide binding] 871585003789 Uncharacterized conserved protein [Function unknown]; Region: COG3268 871585003790 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 871585003791 NAD(P) binding site [chemical binding]; other site 871585003792 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 871585003793 Old yellow enzyme (OYE)-related FMN binding domain, group 2. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_2_FMN; cd04733 871585003794 putative active site [active] 871585003795 putative FMN binding site [chemical binding]; other site 871585003796 putative substrate binding site [chemical binding]; other site 871585003797 putative catalytic residue [active] 871585003798 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 871585003799 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 871585003800 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 871585003801 Benzyl alcohol dehydrogenase; Region: benzyl_alcohol_DH; cd08278 871585003802 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 871585003803 catalytic Zn binding site [ion binding]; other site 871585003804 NAD binding site [chemical binding]; other site 871585003805 structural Zn binding site [ion binding]; other site 871585003806 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 871585003807 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 871585003808 NAD(P) binding site [chemical binding]; other site 871585003809 catalytic residues [active] 871585003810 4-hydroxybenzoate 3-monooxygenase; Region: pbenz_hydroxyl; TIGR02360 871585003811 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 871585003812 Alpha-Ketoglutaric Semialdehyde Dehydrogenase; Region: ALDH_KGSADH; cd07129 871585003813 dimer interface [polypeptide binding]; other site 871585003814 NADP binding site [chemical binding]; other site 871585003815 catalytic residues [active] 871585003816 Uncharacterized protein conserved in bacteria [Function unknown]; Region: GguC; COG3802 871585003817 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 871585003818 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 871585003819 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 871585003820 putative substrate translocation pore; other site 871585003821 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 871585003822 dihydroxy-acid dehydratase; Validated; Region: PRK06131 871585003823 Transcriptional regulators [Transcription]; Region: FadR; COG2186 871585003824 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 871585003825 DNA-binding site [nucleotide binding]; DNA binding site 871585003826 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 871585003827 Bacterial protein of unknown function (Gcw_chp); Region: Gcw_chp; cl09901 871585003828 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 871585003829 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 871585003830 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 871585003831 dimerization interface [polypeptide binding]; other site 871585003832 muconate and chloromuconate cycloisomerases; Region: mucon_cyclo; TIGR02534 871585003833 Muconate Lactonizing Enzyme (MLE), an homooctameric enzyme, catalyses the conversion of cis,cis-muconate (CCM) to muconolactone (ML) in the catechol branch of the beta-ketoadipate pathway. This pathway is used in soil microbes to breakdown lignin-derived...; Region: MLE; cd03318 871585003834 octamer interface [polypeptide binding]; other site 871585003835 active site 871585003836 muconolactone delta-isomerase; Region: muco_delta; TIGR03221 871585003837 catechol 1,2-dioxygenase, proteobacterial; Region: catechol_proteo; TIGR02439 871585003838 Catechol 1,2 dioxygenase (1,2-CTD) catalyzes an intradiol cleavage reaction of catechol to form cis,cis-muconate. 1,2-CTDs is homodimers with one catalytic non-heme ferric ion per monomer. They belong to the aromatic dioxygenase family, a family of...; Region: 1,2-CTD; cd03460 871585003839 dimer interface [polypeptide binding]; other site 871585003840 active site 871585003841 3-oxoacid CoA-transferase, A subunit; Region: pcaI_scoA_fam; TIGR02429 871585003842 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 871585003843 beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050 871585003844 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 871585003845 dimer interface [polypeptide binding]; other site 871585003846 active site 871585003847 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 871585003848 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 871585003849 Protein related to penicillin acylase [General function prediction only]; Region: COG2366 871585003850 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 871585003851 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 871585003852 active site 871585003853 Escherichia coli NAD+-dependent phenylacetaldehyde dehydrogenase PadA-like; Region: ALDH_PADH_NahF; cd07113 871585003854 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 871585003855 NAD(P) binding site [chemical binding]; other site 871585003856 catalytic residues [active] 871585003857 choline dehydrogenase; Validated; Region: PRK02106 871585003858 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 871585003859 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 871585003860 tyramine oxidase; Provisional; Region: tynA; PRK14696 871585003861 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 871585003862 Copper amine oxidase, N3 domain; Region: Cu_amine_oxidN3; pfam02728 871585003863 Copper amine oxidase, enzyme domain; Region: Cu_amine_oxid; pfam01179 871585003864 DNA-binding transcriptional activator FeaR; Provisional; Region: PRK09685 871585003865 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 871585003866 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 871585003867 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 871585003868 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 871585003869 FMN-binding pocket [chemical binding]; other site 871585003870 flavin binding motif; other site 871585003871 phosphate binding motif [ion binding]; other site 871585003872 beta-alpha-beta structure motif; other site 871585003873 NAD binding pocket [chemical binding]; other site 871585003874 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 871585003875 catalytic loop [active] 871585003876 iron binding site [ion binding]; other site 871585003877 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 871585003878 classical (c) SDRs; Region: SDR_c; cd05233 871585003879 NAD(P) binding site [chemical binding]; other site 871585003880 active site 871585003881 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 871585003882 benzoate 1,2-dioxygenase, large subunit; Region: benzo_1_2_benA; TIGR03229 871585003883 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 871585003884 [2Fe-2S] cluster binding site [ion binding]; other site 871585003885 C-terminal catalytic domain of the oxygenase alpha subunit of Pseudomonas resinovorans strain CA10 anthranilate 1,2-dioxygenase and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_AntDO-like; cd08879 871585003886 putative alpha subunit interface [polypeptide binding]; other site 871585003887 putative active site [active] 871585003888 putative substrate binding site [chemical binding]; other site 871585003889 Fe binding site [ion binding]; other site 871585003890 SnoaL-like domain; Region: SnoaL_4; pfam13577 871585003891 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 871585003892 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 871585003893 active site 871585003894 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 871585003895 Amidase; Region: Amidase; cl11426 871585003896 Transcriptional regulators [Transcription]; Region: MarR; COG1846 871585003897 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 871585003898 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 871585003899 Major Facilitator Superfamily; Region: MFS_1; pfam07690 871585003900 putative substrate translocation pore; other site 871585003901 outer membrane porin, OprD family; Region: OprD; pfam03573 871585003902 short chain dehydrogenase; Provisional; Region: PRK08251 871585003903 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 871585003904 NAD(P) binding site [chemical binding]; other site 871585003905 active site 871585003906 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 871585003907 catalytic core [active] 871585003908 thiamine kinase; Region: ycfN_thiK; TIGR02721 871585003909 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 871585003910 putative active site [active] 871585003911 putative substrate binding site [chemical binding]; other site 871585003912 ATP binding site [chemical binding]; other site 871585003913 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 871585003914 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 871585003915 active site 871585003916 Transcriptional regulator [Transcription]; Region: LysR; COG0583 871585003917 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 871585003918 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 871585003919 substrate binding pocket [chemical binding]; other site 871585003920 dimerization interface [polypeptide binding]; other site 871585003921 beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Region: pcaR_pcaU; TIGR02431 871585003922 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 871585003923 Bacterial transcriptional regulator; Region: IclR; pfam01614 871585003924 potential frameshift: common BLAST hit: gi|215483273|ref|YP_002325480.1| Metallo-beta-lactamase superfamily protein 871585003925 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 871585003926 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 871585003927 Predicted transporter component [General function prediction only]; Region: COG2391 871585003928 Domain of unknown function (DUF4341); Region: DUF4341; pfam14241 871585003929 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 871585003930 membrane-bound PQQ-dependent dehydrogenase, glucose/quinate/shikimate family; Region: PQQ_membr_DH; TIGR03074 871585003931 Predicted membrane protein (DUF2157); Region: DUF2157; cl10480 871585003932 Membrane-bound PQQ-dependent glucose dehydrogenase; Region: PQQ_mGDH; cd10280 871585003933 Trp docking motif [polypeptide binding]; other site 871585003934 putative active site [active] 871585003935 Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966 871585003936 Right handed beta helix region; Region: Beta_helix; pfam13229 871585003937 Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502 871585003938 3-dehydroquinate dehydratase [Amino acid transport and metabolism]; Region: AroD; COG0710 871585003939 active site 871585003940 catalytic residue [active] 871585003941 dimer interface [polypeptide binding]; other site 871585003942 Protocatechuate 3,4-dioxygenase beta subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PcaH; COG3485 871585003943 Protocatechuate 3,4-dioxygenase (3,4-PCD) , alpha subunit. 3,4-PCD catalyzes the oxidative ring cleavage of 3,4-dihydroxybenzoate to produce beta-carboxy-cis,cis-muconate. 3,4-PCDs are large aggregates of 12 protomers, each composed of an alpha- and...; Region: 3,4-PCD_alpha; cd03463 871585003944 heterodimer interface [polypeptide binding]; other site 871585003945 active site 871585003946 Protocatechuate 3,4-dioxygenase (3,4-PCD) , beta subunit. 3,4-PCD catalyzes the oxidative ring cleavage of 3,4-dihydroxybenzoate to produce beta-carboxy-cis,cis-muconate. 3,4-PCDs are large aggregates of 12 protomers, each composed of an alpha- and...; Region: 3,4-PCD_beta; cd03464 871585003947 heterodimer interface [polypeptide binding]; other site 871585003948 multimer interface [polypeptide binding]; other site 871585003949 protocatechuate 3,4-dioxygenase, beta subunit; Region: protocat_beta; TIGR02422 871585003950 active site 871585003951 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 871585003952 benzoate transport; Region: 2A0115; TIGR00895 871585003953 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 871585003954 putative substrate translocation pore; other site 871585003955 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 871585003956 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 871585003957 3-carboxy-cis,cis-muconate cycloisomerase; Provisional; Region: PRK09053 871585003958 prokaryotic 3-carboxy-cis,cis-muconate cycloisomerase (CMLE)_like; Region: pCLME; cd01597 871585003959 tetramer interface [polypeptide binding]; other site 871585003960 active site 871585003961 beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050 871585003962 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 871585003963 dimer interface [polypeptide binding]; other site 871585003964 active site 871585003965 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 871585003966 Coenzyme A transferase; Region: CoA_trans; cl17247 871585003967 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 871585003968 substrate binding site; other site 871585003969 dimer interface; other site 871585003970 Septum formation initiator; Region: DivIC; cl17659 871585003971 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 871585003972 Outer membrane receptor for ferric coprogen and ferric-rhodotorulic acid [Inorganic ion transport and metabolism]; Region: FhuE; COG4773 871585003973 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 871585003974 N-terminal plug; other site 871585003975 ligand-binding site [chemical binding]; other site 871585003976 Predicted membrane protein [Function unknown]; Region: COG2323 871585003977 enolase; Provisional; Region: eno; PRK00077 871585003978 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 871585003979 dimer interface [polypeptide binding]; other site 871585003980 metal binding site [ion binding]; metal-binding site 871585003981 substrate binding pocket [chemical binding]; other site 871585003982 2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198 871585003983 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 871585003984 CTP synthetase; Validated; Region: pyrG; PRK05380 871585003985 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 871585003986 Catalytic site [active] 871585003987 active site 871585003988 UTP binding site [chemical binding]; other site 871585003989 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 871585003990 active site 871585003991 putative oxyanion hole; other site 871585003992 catalytic triad [active] 871585003993 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687 871585003994 Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118 871585003995 Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; Region: COG0429 871585003996 SGNH_hydrolase subfamily, FeeA, FeeB and similar esterases/lipases. FeeA and FeeB are part of a biosynthetic gene cluster and may participate in the biosynthesis of long-chain N-acyltyrosines by providing saturated and unsaturated fatty acids, which it...; Region: FeeA_FeeB_like; cd01836 871585003997 active site 871585003998 catalytic triad [active] 871585003999 oxyanion hole [active] 871585004000 SnoaL-like domain; Region: SnoaL_2; pfam12680 871585004001 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 871585004002 2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930 871585004003 active site 871585004004 FMN binding site [chemical binding]; other site 871585004005 2,4-decadienoyl-CoA binding site; other site 871585004006 catalytic residue [active] 871585004007 4Fe-4S cluster binding site [ion binding]; other site 871585004008 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 871585004009 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 871585004010 Predicted transcriptional regulators [Transcription]; Region: COG1695 871585004011 Transcriptional regulator PadR-like family; Region: PadR; cl17335 871585004012 Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400 871585004013 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 871585004014 phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12755 871585004015 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 871585004016 hypothetical protein; Provisional; Region: PRK02237 871585004017 ATP-dependent Clp protease ATP-binding subunit clpA; Region: ClpA; TIGR02639 871585004018 Clp amino terminal domain; Region: Clp_N; pfam02861 871585004019 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 871585004020 Walker A motif; other site 871585004021 ATP binding site [chemical binding]; other site 871585004022 Walker B motif; other site 871585004023 arginine finger; other site 871585004024 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 871585004025 Walker A motif; other site 871585004026 ATP binding site [chemical binding]; other site 871585004027 Walker B motif; other site 871585004028 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 871585004029 Uncharacterized conserved protein [Function unknown]; Region: COG2127 871585004030 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 871585004031 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 871585004032 Protein of unknown function DUF45; Region: DUF45; pfam01863 871585004033 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 871585004034 tetramer (dimer of dimers) interface [polypeptide binding]; other site 871585004035 active site 871585004036 dimer interface [polypeptide binding]; other site 871585004037 threonine dehydratase; Reviewed; Region: PRK09224 871585004038 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 871585004039 tetramer interface [polypeptide binding]; other site 871585004040 pyridoxal 5'-phosphate binding site [chemical binding]; other site 871585004041 catalytic residue [active] 871585004042 First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906 871585004043 putative Ile/Val binding site [chemical binding]; other site 871585004044 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 871585004045 putative Ile/Val binding site [chemical binding]; other site 871585004046 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 871585004047 TrkA-N domain; Region: TrkA_N; pfam02254 871585004048 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 871585004049 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 871585004050 Protein of unknown function (DUF3121); Region: DUF3121; cl11879 871585004051 The outer membrane phospholipase A (OMPLA) is an integral membrane enzyme that catalyses the hydrolysis of acylester bonds in phospholipids using calcium as a cofactor. The enzyme has a fold of transmembrane beta-barrels and is widespread among...; Region: OMPLA; cd00541 871585004052 dimerization interface [polypeptide binding]; other site 871585004053 substrate binding site [chemical binding]; other site 871585004054 active site 871585004055 calcium binding site [ion binding]; other site 871585004056 Predicted Zn-dependent peptidases, insulinase-like [General function prediction only]; Region: COG1026 871585004057 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 871585004058 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 871585004059 Peptidase M16C associated; Region: M16C_assoc; pfam08367 871585004060 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 871585004061 Adenosine kinase (AK) catalyzes the phosphorylation of ribofuranosyl-containing nucleoside analogues at the 5'-hydroxyl using ATP or GTP as the phosphate donor.The physiological function of AK is associated with the regulation of extracellular...; Region: adenosine_kinase; cd01168 871585004062 substrate binding site [chemical binding]; other site 871585004063 ATP binding site [chemical binding]; other site 871585004064 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 871585004065 iron-sulfur cluster [ion binding]; other site 871585004066 [2Fe-2S] cluster binding site [ion binding]; other site 871585004067 Protein of unknown function (DUF1449); Region: DUF1449; pfam07290 871585004068 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 871585004069 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562 871585004070 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 871585004071 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 871585004072 Cyd operon protein YbgE (Cyd_oper_YbgE); Region: Cyd_oper_YbgE; pfam09600 871585004073 Uncharacterized protein conserved in bacteria (DUF2057); Region: DUF2057; pfam09829 871585004074 Nitroreductase-like family 4. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_4; cd02140 871585004075 dimer interface [polypeptide binding]; other site 871585004076 FMN binding site [chemical binding]; other site 871585004077 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 871585004078 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 871585004079 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 871585004080 P loop; other site 871585004081 GTP binding site [chemical binding]; other site 871585004082 Protein of unknown function (DUF2750); Region: DUF2750; pfam11042 871585004083 FOG: CBS domain [General function prediction only]; Region: COG0517 871585004084 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_10; cd04623 871585004085 acetylornithine aminotransferase; Provisional; Region: PRK02627 871585004086 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 871585004087 inhibitor-cofactor binding pocket; inhibition site 871585004088 pyridoxal 5'-phosphate binding site [chemical binding]; other site 871585004089 catalytic residue [active] 871585004090 Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028 871585004091 putative GSH binding site [chemical binding]; other site 871585004092 catalytic residues [active] 871585004093 LysR family transcriptional regulator; Provisional; Region: PRK14997 871585004094 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 871585004095 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_4; cd08473 871585004096 putative effector binding pocket; other site 871585004097 putative dimerization interface [polypeptide binding]; other site 871585004098 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 871585004099 active site 871585004100 Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547 871585004101 Uncharacterized protein, possibly involved in utilization of glycolate and propanediol [General function prediction only]; Region: GlcG; COG3193 871585004102 Predicted alpha/beta hydrolase [General function prediction only]; Region: COG4757 871585004103 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 871585004104 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 871585004105 bifunctional PTS system fructose-specific transporter subunit IIA/HPr protein; Provisional; Region: PRK11109 871585004106 active site 871585004107 phosphorylation site [posttranslational modification] 871585004108 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cl00163 871585004109 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 871585004110 dimerization domain swap beta strand [polypeptide binding]; other site 871585004111 regulatory protein interface [polypeptide binding]; other site 871585004112 active site 871585004113 regulatory phosphorylation site [posttranslational modification]; other site 871585004114 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 871585004115 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 871585004116 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 871585004117 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 871585004118 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 871585004119 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 871585004120 putative substrate binding site [chemical binding]; other site 871585004121 putative ATP binding site [chemical binding]; other site 871585004122 PTS system fructose-specific transporter subunits IIBC; Provisional; Region: PRK10712 871585004123 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 871585004124 active site 871585004125 P-loop; other site 871585004126 phosphorylation site [posttranslational modification] 871585004127 PTS system, fructose subfamily, IIC component; Region: PTS_IIC_fructo; TIGR01427 871585004128 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 871585004129 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 871585004130 putative DNA binding site [nucleotide binding]; other site 871585004131 putative Zn2+ binding site [ion binding]; other site 871585004132 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 871585004133 PAS domain; Region: PAS_9; pfam13426 871585004134 putative active site [active] 871585004135 heme pocket [chemical binding]; other site 871585004136 PAS fold; Region: PAS_4; pfam08448 871585004137 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 871585004138 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 871585004139 metal binding site [ion binding]; metal-binding site 871585004140 active site 871585004141 I-site; other site 871585004142 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 871585004143 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 871585004144 Ligand Binding Site [chemical binding]; other site 871585004145 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 871585004146 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 871585004147 Uncharacterized ACR, COG2135; Region: DUF159; pfam02586 871585004148 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 871585004149 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 871585004150 Sulfate transporter family; Region: Sulfate_transp; pfam00916 871585004151 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 871585004152 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 871585004153 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 871585004154 Peptidase S8 family domain in ProteinaseK-like proteins; Region: Peptidases_S8_PCSK9_ProteinaseK_like; cd04077 871585004155 calcium binding site 2 [ion binding]; other site 871585004156 active site 871585004157 catalytic triad [active] 871585004158 calcium binding site 1 [ion binding]; other site 871585004159 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 871585004160 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 871585004161 Kynureninase [Amino acid transport and metabolism]; Region: COG3844 871585004162 kynureninase; Region: kynureninase; TIGR01814 871585004163 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 871585004164 catalytic residue [active] 871585004165 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 871585004166 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 871585004167 putative DNA binding site [nucleotide binding]; other site 871585004168 putative Zn2+ binding site [ion binding]; other site 871585004169 AsnC family; Region: AsnC_trans_reg; pfam01037 871585004170 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 871585004171 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 871585004172 haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509 871585004173 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 871585004174 motif II; other site 871585004175 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 871585004176 RNA binding surface [nucleotide binding]; other site 871585004177 recombinase A; Provisional; Region: recA; PRK09354 871585004178 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 871585004179 hexamer interface [polypeptide binding]; other site 871585004180 Walker A motif; other site 871585004181 ATP binding site [chemical binding]; other site 871585004182 Walker B motif; other site 871585004183 recombination regulator RecX; Reviewed; Region: recX; PRK00117 871585004184 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1729 871585004185 potential frameshift: common BLAST hit: gi|299769710|ref|YP_003731736.1| UDP-N-acetylglucosamine acyltransferase 871585004186 Udp N-acetylglucosamine O-acyltransferase; Domain 2; Region: Acetyltransf_11; pfam13720 871585004187 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 871585004188 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 871585004189 active site 871585004190 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 871585004191 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 871585004192 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 871585004193 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 871585004194 trimer interface [polypeptide binding]; other site 871585004195 active site 871585004196 UDP-GlcNAc binding site [chemical binding]; other site 871585004197 lipid binding site [chemical binding]; lipid-binding site 871585004198 Outer membrane protein (OmpH-like); Region: OmpH; pfam03938 871585004199 outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303 871585004200 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 871585004201 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 871585004202 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 871585004203 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 871585004204 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 871585004205 Surface antigen; Region: Bac_surface_Ag; pfam01103 871585004206 potential frameshift: common BLAST hit: gi|299769705|ref|YP_003731731.1| putative membrane-associated Zn-dependent proteases 1 871585004207 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 871585004208 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 871585004209 putative substrate binding region [chemical binding]; other site 871585004210 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 871585004211 active site 871585004212 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 871585004213 protein binding site [polypeptide binding]; other site 871585004214 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 871585004215 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 871585004216 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 871585004217 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 871585004218 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 871585004219 CDP-diglyceride synthase; Provisional; Region: cdsA; PRK11624 871585004220 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 871585004221 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 871585004222 catalytic residue [active] 871585004223 putative FPP diphosphate binding site; other site 871585004224 putative FPP binding hydrophobic cleft; other site 871585004225 dimer interface [polypeptide binding]; other site 871585004226 putative IPP diphosphate binding site; other site 871585004227 ribosome recycling factor; Reviewed; Region: frr; PRK00083 871585004228 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 871585004229 hinge region; other site 871585004230 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 871585004231 putative nucleotide binding site [chemical binding]; other site 871585004232 uridine monophosphate binding site [chemical binding]; other site 871585004233 homohexameric interface [polypeptide binding]; other site 871585004234 ribosomal protein S12 methylthiotransferase; Provisional; Region: rimO; PRK14862 871585004235 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 871585004236 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 871585004237 FeS/SAM binding site; other site 871585004238 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 871585004239 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 871585004240 putative active site [active] 871585004241 heme pocket [chemical binding]; other site 871585004242 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 871585004243 dimer interface [polypeptide binding]; other site 871585004244 phosphorylation site [posttranslational modification] 871585004245 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 871585004246 ATP binding site [chemical binding]; other site 871585004247 Mg2+ binding site [ion binding]; other site 871585004248 G-X-G motif; other site 871585004249 nitrogen regulation protein NR(I); Region: ntrC; TIGR01818 871585004250 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 871585004251 active site 871585004252 phosphorylation site [posttranslational modification] 871585004253 intermolecular recognition site; other site 871585004254 dimerization interface [polypeptide binding]; other site 871585004255 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 871585004256 Walker A motif; other site 871585004257 ATP binding site [chemical binding]; other site 871585004258 Walker B motif; other site 871585004259 arginine finger; other site 871585004260 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 871585004261 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 871585004262 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 871585004263 ornithine carbamoyltransferase; Provisional; Region: PRK00779 871585004264 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 871585004265 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 871585004266 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 871585004267 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 871585004268 homotrimer interaction site [polypeptide binding]; other site 871585004269 zinc binding site [ion binding]; other site 871585004270 CDP-binding sites; other site 871585004271 D-amino acid dehydrogenase small subunit; Provisional; Region: PRK12409 871585004272 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 871585004273 hydroxyglutarate oxidase; Provisional; Region: PRK11728 871585004274 Sensors of blue-light using FAD; Region: BLUF; pfam04940 871585004275 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 871585004276 Uncharacterized protein family (UPF0227); Region: UPF0227; cl14886 871585004277 Fe-S protein assembly chaperone HscA; Region: HscA; TIGR01991 871585004278 fumarate hydratase; Reviewed; Region: fumC; PRK00485 871585004279 Class II fumarases; Region: Fumarase_classII; cd01362 871585004280 active site 871585004281 tetramer interface [polypeptide binding]; other site 871585004282 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 871585004283 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 871585004284 NAD(P) binding site [chemical binding]; other site 871585004285 active site 871585004286 sulfur relay protein TusD/DsrE; Region: sulf_tusD_dsrE; TIGR03012 871585004287 Dissimilatory sulfite reductase (desulfoviridin), gamma subunit [Inorganic ion transport and metabolism]; Region: DsrC; COG2920 871585004288 DsrC like protein; Region: DsrC; pfam04358 871585004289 EamA-like transporter family; Region: EamA; pfam00892 871585004290 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 871585004291 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 871585004292 DNA-binding site [nucleotide binding]; DNA binding site 871585004293 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 871585004294 pyridoxal 5'-phosphate binding site [chemical binding]; other site 871585004295 homodimer interface [polypeptide binding]; other site 871585004296 catalytic residue [active] 871585004297 Predicted transcriptional regulators [Transcription]; Region: COG1733 871585004298 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 871585004299 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 871585004300 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 871585004301 dimer interface [polypeptide binding]; other site 871585004302 putative functional site; other site 871585004303 putative MPT binding site; other site 871585004304 bifunctional molybdenum cofactor biosynthesis protein MoaC/MogA; Provisional; Region: moaC; PRK03604 871585004305 MoaC family. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine derivative to the precursor...; Region: MoaC; cl00242 871585004306 trimer interface [polypeptide binding]; other site 871585004307 dimer interface [polypeptide binding]; other site 871585004308 putative active site [active] 871585004309 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 871585004310 MPT binding site; other site 871585004311 trimer interface [polypeptide binding]; other site 871585004312 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 871585004313 MoaE homodimer interface [polypeptide binding]; other site 871585004314 MoaD interaction [polypeptide binding]; other site 871585004315 active site residues [active] 871585004316 molybdenum cofactor biosynthesis protein A, bacterial; Region: moaA; TIGR02666 871585004317 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 871585004318 FeS/SAM binding site; other site 871585004319 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 871585004320 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 871585004321 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 871585004322 molybdopterin cofactor binding site; other site 871585004323 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 871585004324 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 871585004325 The MopB_CT_1 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. This CD is of the...; Region: MopB_CT_1; cd02782 871585004326 putative molybdopterin cofactor binding site; other site 871585004327 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 871585004328 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 871585004329 GTP binding site; other site 871585004330 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 871585004331 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 871585004332 [4Fe-4S] binding site [ion binding]; other site 871585004333 molybdopterin cofactor binding site; other site 871585004334 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 871585004335 molybdopterin cofactor binding site; other site 871585004336 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 871585004337 Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529 871585004338 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 871585004339 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 871585004340 nitrite reductase subunit NirD; Provisional; Region: PRK14989 871585004341 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 871585004342 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 871585004343 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 871585004344 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 871585004345 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 871585004346 active site 871585004347 phosphorylation site [posttranslational modification] 871585004348 intermolecular recognition site; other site 871585004349 dimerization interface [polypeptide binding]; other site 871585004350 ANTAR domain; Region: ANTAR; pfam03861 871585004351 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 871585004352 NMT1-like family; Region: NMT1_2; pfam13379 871585004353 2,3-diaminopropionate biosynthesis protein SbnA; Region: PLP_SbnA_fam; TIGR03945 871585004354 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 871585004355 dimer interface [polypeptide binding]; other site 871585004356 pyridoxal 5'-phosphate binding site [chemical binding]; other site 871585004357 catalytic residue [active] 871585004358 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 871585004359 2,3-diaminopropionate biosynthesis protein SbnB; Region: dehyd_SbnB_fam; TIGR03944 871585004360 IucA / IucC family; Region: IucA_IucC; pfam04183 871585004361 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 871585004362 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 871585004363 drug efflux system protein MdtG; Provisional; Region: PRK09874 871585004364 putative substrate translocation pore; other site 871585004365 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 871585004366 IucA / IucC family; Region: IucA_IucC; pfam04183 871585004367 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 871585004368 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 871585004369 IucA / IucC family; Region: IucA_IucC; pfam04183 871585004370 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 871585004371 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 871585004372 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 871585004373 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 871585004374 N-terminal plug; other site 871585004375 ligand-binding site [chemical binding]; other site 871585004376 DNA polymerase V subunit UmuC; Reviewed; Region: umuC; PRK03609 871585004377 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 871585004378 active site 871585004379 DNA binding site [nucleotide binding] 871585004380 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 871585004381 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 871585004382 Dehydroquinase class II; Region: DHquinase_II; pfam01220 871585004383 trimer interface [polypeptide binding]; other site 871585004384 active site 871585004385 dimer interface [polypeptide binding]; other site 871585004386 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 871585004387 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 871585004388 carboxyltransferase (CT) interaction site; other site 871585004389 biotinylation site [posttranslational modification]; other site 871585004390 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 871585004391 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 871585004392 ATP-grasp domain; Region: ATP-grasp_4; cl17255 871585004393 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 871585004394 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 871585004395 putative substrate translocation pore; other site 871585004396 putative 3-phenylpropionic acid transporter; Provisional; Region: PRK11128 871585004397 Spore Coat Protein U domain; Region: SCPU; pfam05229 871585004398 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 871585004399 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 871585004400 PapC C-terminal domain; Region: PapC_C; pfam13953 871585004401 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 871585004402 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 871585004403 Spore Coat Protein U domain; Region: SCPU; pfam05229 871585004404 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 871585004405 Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069 871585004406 active site 871585004407 FMN binding site [chemical binding]; other site 871585004408 substrate binding site [chemical binding]; other site 871585004409 3Fe-4S cluster binding site [ion binding]; other site 871585004410 Choloylglycine hydrolase (CGH) is a bile salt-modifying enzyme that hydrolyzes non-peptide carbon-nitrogen bonds in choloylglycine and choloyltaurine, both of which are present in bile. CGH is present in a number of probiotic microbial organisms that...; Region: Ntn_CGH; cd01902 871585004411 Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275 871585004412 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 871585004413 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 871585004414 Uncharacterized conserved protein [Function unknown]; Region: COG1434 871585004415 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 871585004416 putative active site [active] 871585004417 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK00046 871585004418 FAD binding domain; Region: FAD_binding_4; pfam01565 871585004419 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 871585004420 Low molecular weight phosphatase family; Region: LMWPc; cd00115 871585004421 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 871585004422 Predicted transcriptional regulators [Transcription]; Region: COG1733 871585004423 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 871585004424 Fels-1 Prophage Protein-like; Region: Fels1; pfam05666 871585004425 Fels-1 Prophage Protein-like; Region: Fels1; pfam05666 871585004426 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 871585004427 5-hydroxyvalerate dehydrogenase (HVD) catalyzes the oxidation of 5-hydroxyvalerate to 5-oxovalerate with NAD+ as cofactor; Region: HVD; cd08193 871585004428 putative active site [active] 871585004429 metal binding site [ion binding]; metal-binding site 871585004430 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 871585004431 active site 871585004432 phospholipase C, phosphocholine-specific, Pseudomonas-type; Region: PC_PLC; TIGR03396 871585004433 Phosphoesterase family; Region: Phosphoesterase; pfam04185 871585004434 Domain of unknown function (DUF756); Region: DUF756; pfam05506 871585004435 Domain of unknown function (DUF756); Region: DUF756; pfam05506 871585004436 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14960 871585004437 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 871585004438 Walker A motif; other site 871585004439 ATP binding site [chemical binding]; other site 871585004440 Walker B motif; other site 871585004441 arginine finger; other site 871585004442 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 871585004443 Metallo-peptidase family M12B Reprolysin-like; Region: Reprolysin_3; pfam13582 871585004444 active site 871585004445 methyl viologen resistance protein SmvA; Provisional; Region: PRK14995 871585004446 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 871585004447 putative substrate translocation pore; other site 871585004448 TetR family transcriptional regulator; Provisional; Region: PRK14996 871585004449 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 871585004450 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 871585004451 Beta-lactamase; Region: Beta-lactamase; pfam00144 871585004452 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 871585004453 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 871585004454 active site 2 [active] 871585004455 active site 1 [active] 871585004456 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08261 871585004457 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 871585004458 NAD(P) binding site [chemical binding]; other site 871585004459 active site 871585004460 acetyl-CoA acetyltransferase; Provisional; Region: PRK09268 871585004461 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 871585004462 dimer interface [polypeptide binding]; other site 871585004463 active site 871585004464 Bacterial Transmembrane Pair family; Region: BTP; pfam05232 871585004465 Bacterial Transmembrane Pair family; Region: BTP; pfam05232 871585004466 Transcriptional regulator [Transcription]; Region: LysR; COG0583 871585004467 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 871585004468 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 871585004469 dimerization interface [polypeptide binding]; other site 871585004470 transaldolase-like protein; Provisional; Region: PTZ00411 871585004471 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 871585004472 active site 871585004473 dimer interface [polypeptide binding]; other site 871585004474 catalytic residue [active] 871585004475 leucine export protein LeuE; Provisional; Region: PRK10958 871585004476 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 871585004477 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 871585004478 putative DNA binding site [nucleotide binding]; other site 871585004479 putative Zn2+ binding site [ion binding]; other site 871585004480 AsnC family; Region: AsnC_trans_reg; pfam01037 871585004481 Benzoate membrane transport protein; Region: BenE; pfam03594 871585004482 benzoate transporter; Region: benE; TIGR00843 871585004483 RDD family; Region: RDD; pfam06271 871585004484 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 871585004485 Ligand Binding Site [chemical binding]; other site 871585004486 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 871585004487 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 871585004488 Walker A/P-loop; other site 871585004489 ATP binding site [chemical binding]; other site 871585004490 Q-loop/lid; other site 871585004491 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 871585004492 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 871585004493 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 871585004494 Coenzyme A binding pocket [chemical binding]; other site 871585004495 Bacterial OB fold (BOF) protein; Region: BOF; cl01196 871585004496 Transcriptional regulator [Transcription]; Region: LysR; COG0583 871585004497 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 871585004498 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 871585004499 dimerization interface [polypeptide binding]; other site 871585004500 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 871585004501 Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072 871585004502 Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737 871585004503 catalytic residues [active] 871585004504 Gram-negative bacterial tonB protein; Region: TonB; cl10048 871585004505 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 871585004506 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 871585004507 catalytic triad [active] 871585004508 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cl17326 871585004509 metal binding site 2 [ion binding]; metal-binding site 871585004510 putative DNA binding helix; other site 871585004511 metal binding site 1 [ion binding]; metal-binding site 871585004512 structural Zn2+ binding site [ion binding]; other site 871585004513 Fe(II)-dependent oxygenase superfamily protein; Provisional; Region: PRK05467 871585004514 Outer membrane receptor for monomeric catechols [Inorganic ion transport and metabolism]; Region: Fiu; COG4774 871585004515 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 871585004516 N-terminal plug; other site 871585004517 ligand-binding site [chemical binding]; other site 871585004518 Outer membrane receptor for Fe3+-dicitrate [Inorganic ion transport and metabolism]; Region: FecA; COG4772 871585004519 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 871585004520 N-terminal plug; other site 871585004521 ligand-binding site [chemical binding]; other site 871585004522 chorismate mutase; Provisional; Region: PRK08055 871585004523 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 871585004524 active site 871585004525 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 871585004526 NAD(P) binding site [chemical binding]; other site 871585004527 active site 871585004528 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 871585004529 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 871585004530 C-terminal domain interface [polypeptide binding]; other site 871585004531 GSH binding site (G-site) [chemical binding]; other site 871585004532 dimer interface [polypeptide binding]; other site 871585004533 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299 871585004534 N-terminal domain interface [polypeptide binding]; other site 871585004535 Spore Coat Protein U domain; Region: SCPU; pfam05229 871585004536 potential frameshift: common BLAST hit: gi|299769584|ref|YP_003731610.1| Hypothetical outer membrane usher protein yraJ precursor 871585004537 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 871585004538 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 871585004539 PapC C-terminal domain; Region: PapC_C; pfam13953 871585004540 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 871585004541 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 871585004542 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 871585004543 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 871585004544 Spore Coat Protein U domain; Region: SCPU; pfam05229 871585004545 aminopeptidase N; Provisional; Region: pepN; PRK14015 871585004546 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_1; cd09600 871585004547 active site 871585004548 Zn binding site [ion binding]; other site 871585004549 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 871585004550 substrate binding site [chemical binding]; other site 871585004551 multimerization interface [polypeptide binding]; other site 871585004552 ATP binding site [chemical binding]; other site 871585004553 5-carboxymethyl-2-hydroxymuconate isomerase (CHMI) is a trimeric enzyme catalyzing the isomerization of the unsaturated ketone 5-(carboxymethyl)-2-hydroxymuconate to 5-(carboxymethyl)-2-oxo-3-hexene-1,6-dionate. This is one step in the...; Region: CHMI; cd00580 871585004554 putative substrate binding pocket [chemical binding]; other site 871585004555 trimer interface [polypeptide binding]; other site 871585004556 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 871585004557 PIF1-like helicase; Region: PIF1; pfam05970 871585004558 Walker A motif; other site 871585004559 ATP binding site [chemical binding]; other site 871585004560 Walker B motif; other site 871585004561 Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176 871585004562 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 871585004563 dimer interface [polypeptide binding]; other site 871585004564 active site 871585004565 metal binding site [ion binding]; metal-binding site 871585004566 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 871585004567 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 871585004568 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 871585004569 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 871585004570 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 871585004571 NAD(P) binding site [chemical binding]; other site 871585004572 catalytic residues [active] 871585004573 ethanolamine permease; Region: 2A0305; TIGR00908 871585004574 ethanolamine ammonia lyase large subunit; Provisional; Region: PRK15067 871585004575 Ethanolamine ammonia lyase large subunit (EutB); Region: EutB; pfam06751 871585004576 ethanolamine ammonia-lyase small subunit; Provisional; Region: PRK05465 871585004577 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 871585004578 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 871585004579 catalytic triad [active] 871585004580 potential frameshift: common BLAST hit: gi|215483057|ref|YP_002325262.1| glutaminyl-tRNA synthetase 871585004581 tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950 871585004582 tRNA synthetases class I (E and Q), catalytic domain; Region: tRNA-synt_1c; pfam00749 871585004583 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 871585004584 active site 871585004585 HIGH motif; other site 871585004586 nucleotide binding site [chemical binding]; other site 871585004587 catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807 871585004588 KMSKS motif; other site 871585004589 tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950 871585004590 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 871585004591 substrate binding site [chemical binding]; other site 871585004592 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 871585004593 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 871585004594 putative active site [active] 871585004595 putative metal binding site [ion binding]; other site 871585004596 NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149 871585004597 dimer interface [polypeptide binding]; other site 871585004598 FMN binding site [chemical binding]; other site 871585004599 EamA-like transporter family; Region: EamA; pfam00892 871585004600 bacterial Hfq-like; Region: Hfq; cd01716 871585004601 hexamer interface [polypeptide binding]; other site 871585004602 Sm1 motif; other site 871585004603 RNA binding site [nucleotide binding]; other site 871585004604 Sm2 motif; other site 871585004605 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 871585004606 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 871585004607 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 871585004608 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 871585004609 ATP binding site [chemical binding]; other site 871585004610 Mg2+ binding site [ion binding]; other site 871585004611 G-X-G motif; other site 871585004612 MutL_Trans_MutL: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to Escherichia coli MutL. EcMutL belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second...; Region: MutL_Trans_MutL; cd03482 871585004613 ATP binding site [chemical binding]; other site 871585004614 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 871585004615 Uncharacterized P-loop hydrolase UPF0079; Region: UPF0079; cl00520 871585004616 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 871585004617 Pseudouridine synthase, a subgroup of the RluA family; Region: PSRA_1; cd02558 871585004618 probable active site [active] 871585004619 RelB antitoxin; Region: RelB; cl01171 871585004620 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 871585004621 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 871585004622 Coenzyme A binding pocket [chemical binding]; other site 871585004623 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 871585004624 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 871585004625 RNA binding surface [nucleotide binding]; other site 871585004626 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 871585004627 active site 871585004628 uracil binding [chemical binding]; other site 871585004629 Protein of unknown function (DUF441); Region: DUF441; pfam04284 871585004630 Transcriptional regulator [Transcription]; Region: LysR; COG0583 871585004631 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 871585004632 The C-terminal substrate binding domain of LysR-type transcriptional regulator metR, which regulates the expression of methionine biosynthetic genes, contains type 2 periplasmic binding fold; Region: PBP2_MetR; cd08441 871585004633 putative dimerization interface [polypeptide binding]; other site 871585004634 Domain of unknown function (DUF4198); Region: DUF4198; pfam10670 871585004635 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 871585004636 putative substrate translocation pore; other site 871585004637 Major Facilitator Superfamily; Region: MFS_1; pfam07690 871585004638 Ion transport protein; Region: Ion_trans; pfam00520 871585004639 Ion channel; Region: Ion_trans_2; pfam07885 871585004640 bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238 871585004641 Aconitase B swivel domain. Aconitate hydratase B is involved in energy metabolism as part of the TCA cycle. It catalyses the formation of cis-aconitate from citrate. This is the aconitase swivel domain, which undergoes swivelling conformational change in...; Region: AcnB_Swivel; cd01576 871585004642 substrate binding site [chemical binding]; other site 871585004643 Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle; Region: AcnB; cd01581 871585004644 substrate binding site [chemical binding]; other site 871585004645 ligand binding site [chemical binding]; other site 871585004646 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 871585004647 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911 871585004648 Family of unknown function (DUF490); Region: DUF490; pfam04357 871585004649 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 871585004650 Surface antigen; Region: Bac_surface_Ag; pfam01103 871585004651 lysophospholipid transporter LplT; Provisional; Region: PRK11195 871585004652 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 871585004653 putative substrate translocation pore; other site 871585004654 Demethoxyubiquinone hydroxylase, ferritin-like diiron-binding domain; Region: DMQH; cd01042 871585004655 diiron binding motif [ion binding]; other site 871585004656 Protein of unknown function (DUF2799); Region: DUF2799; pfam10973 871585004657 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 871585004658 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 871585004659 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 871585004660 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 871585004661 active site 871585004662 phosphorylation site [posttranslational modification] 871585004663 intermolecular recognition site; other site 871585004664 dimerization interface [polypeptide binding]; other site 871585004665 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 871585004666 DNA binding site [nucleotide binding] 871585004667 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 871585004668 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 871585004669 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 871585004670 Ligand Binding Site [chemical binding]; other site 871585004671 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 871585004672 dimer interface [polypeptide binding]; other site 871585004673 phosphorylation site [posttranslational modification] 871585004674 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 871585004675 ATP binding site [chemical binding]; other site 871585004676 Mg2+ binding site [ion binding]; other site 871585004677 G-X-G motif; other site 871585004678 potassium-transporting ATPase subunit C; Reviewed; Region: PRK00315 871585004679 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 871585004680 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 871585004681 Soluble P-type ATPase [General function prediction only]; Region: COG4087 871585004682 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 871585004683 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cl00233 871585004684 catalytic center binding site [active] 871585004685 ATP binding site [chemical binding]; other site 871585004686 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 871585004687 homooctamer interface [polypeptide binding]; other site 871585004688 active site 871585004689 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 871585004690 ABC1 family; Region: ABC1; cl17513 871585004691 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 871585004692 substrate binding site [chemical binding]; other site 871585004693 activation loop (A-loop); other site 871585004694 molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690 871585004695 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 871585004696 ATP binding site [chemical binding]; other site 871585004697 substrate interface [chemical binding]; other site 871585004698 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 871585004699 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 871585004700 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 871585004701 active site 871585004702 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08217 871585004703 17hydroxysteroid dehydrogenase type 10 (HSD10)-like, classical (c) SDRs; Region: HSD10-like_SDR_c; cd05371 871585004704 NAD binding site [chemical binding]; other site 871585004705 homodimer interface [polypeptide binding]; other site 871585004706 homotetramer interface [polypeptide binding]; other site 871585004707 active site 871585004708 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 871585004709 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 871585004710 SurA N-terminal domain; Region: SurA_N; pfam09312 871585004711 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 871585004712 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 871585004713 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 871585004714 substrate binding pocket [chemical binding]; other site 871585004715 ABC transporter periplasmic binding protein, urea carboxylase region; Region: ABC_peri_uca; TIGR03427 871585004716 membrane-bound complex binding site; other site 871585004717 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 871585004718 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 871585004719 putative PBP binding loops; other site 871585004720 ABC-ATPase subunit interface; other site 871585004721 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 871585004722 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 871585004723 peptide chain release factor 1; Validated; Region: prfA; PRK00591 871585004724 This domain is found in peptide chain release factors; Region: PCRF; smart00937 871585004725 RF-1 domain; Region: RF-1; pfam00472 871585004726 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 871585004727 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 871585004728 potential catalytic triad [active] 871585004729 conserved cys residue [active] 871585004730 Transcriptional regulator [Transcription]; Region: LysR; COG0583 871585004731 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 871585004732 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 871585004733 putative effector binding pocket; other site 871585004734 dimerization interface [polypeptide binding]; other site 871585004735 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 871585004736 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 871585004737 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 871585004738 PgaD-like protein; Region: PgaD; pfam13994 871585004739 N-glycosyltransferase; Provisional; Region: PRK11204 871585004740 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 871585004741 DXD motif; other site 871585004742 poly-beta-1,6-N-acetyl-D-glucosamine N-deacetylase PgaB; Region: deacetyl_PgaB; TIGR03938 871585004743 N-terminal putative catalytic polysaccharide deacetylase domain of bacterial poly-beta-1,6-N-acetyl-D-glucosamine N-deacetylase PgaB, and similar proteins; Region: CE4_PgaB_5s; cd10964 871585004744 putative active site [active] 871585004745 putative metal binding site [ion binding]; other site 871585004746 poly-beta-1,6 N-acetyl-D-glucosamine export porin PgaA; Region: PGA_TPR_OMP; TIGR03939 871585004747 PEP synthetase regulatory protein; Provisional; Region: PRK05339 871585004748 phosphoenolpyruvate synthase; Validated; Region: PRK06464 871585004749 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 871585004750 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 871585004751 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 871585004752 Domain of unknown function (DUF4339); Region: DUF4339; pfam14237 871585004753 RDD family; Region: RDD; pfam06271 871585004754 cytochrome o ubiquinol oxidase subunit II; Region: CyoA; TIGR01433 871585004755 COX Aromatic Rich Motif; Region: COX_ARM; pfam06481 871585004756 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 871585004757 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 871585004758 D-pathway; other site 871585004759 Putative ubiquinol binding site [chemical binding]; other site 871585004760 Low-spin heme (heme b) binding site [chemical binding]; other site 871585004761 Putative water exit pathway; other site 871585004762 Binuclear center (heme o3/CuB) [ion binding]; other site 871585004763 K-pathway; other site 871585004764 Putative proton exit pathway; other site 871585004765 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 871585004766 Subunit I/III interface [polypeptide binding]; other site 871585004767 Subunit III/IV interface [polypeptide binding]; other site 871585004768 cytochrome o ubiquinol oxidase subunit IV; Provisional; Region: PRK10582 871585004769 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 871585004770 UbiA prenyltransferase family; Region: UbiA; pfam01040 871585004771 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 871585004772 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 871585004773 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 871585004774 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 871585004775 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 871585004776 replicative DNA helicase; Region: DnaB; TIGR00665 871585004777 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 871585004778 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 871585004779 Walker A motif; other site 871585004780 ATP binding site [chemical binding]; other site 871585004781 Walker B motif; other site 871585004782 DNA binding loops [nucleotide binding] 871585004783 Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787 871585004784 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827 871585004785 active site 871585004786 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 871585004787 substrate binding site [chemical binding]; other site 871585004788 catalytic residues [active] 871585004789 dimer interface [polypeptide binding]; other site 871585004790 Bacterial proteasome, beta subunit. The 20S proteasome, multisubunit proteolytic complex, is the central enzyme of nonlysosomal protein degradation in both the cytosol and nucleus. It is composed of 28 subunits arranged as four homoheptameric rings that...; Region: proteasome_beta_bacterial; cd03765 871585004791 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 871585004792 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 871585004793 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 871585004794 Uncharacterized conserved protein [Function unknown]; Region: COG2308 871585004795 potential frameshift: common BLAST hit: gi|213158565|ref|YP_002319863.1| transcriptional factor 871585004796 Predicted transcriptional regulator [Transcription]; Region: COG2378 871585004797 WYL domain; Region: WYL; pfam13280 871585004798 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 871585004799 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 871585004800 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 871585004801 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 871585004802 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 871585004803 S-adenosylmethionine binding site [chemical binding]; other site 871585004804 MJ0042 family finger-like domain; Region: MJ0042_CXXC; TIGR02098 871585004805 Protein of unknown function (DUF3426); Region: DUF3426; pfam11906 871585004806 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 871585004807 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 871585004808 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 871585004809 purine monophosphate binding site [chemical binding]; other site 871585004810 dimer interface [polypeptide binding]; other site 871585004811 putative catalytic residues [active] 871585004812 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 871585004813 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 871585004814 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 871585004815 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 871585004816 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 871585004817 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 871585004818 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 871585004819 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 871585004820 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 871585004821 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 871585004822 Walker A/P-loop; other site 871585004823 ATP binding site [chemical binding]; other site 871585004824 Q-loop/lid; other site 871585004825 ABC transporter signature motif; other site 871585004826 Walker B; other site 871585004827 D-loop; other site 871585004828 H-loop/switch region; other site 871585004829 NIL domain; Region: NIL; pfam09383 871585004830 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 871585004831 dimer interface [polypeptide binding]; other site 871585004832 conserved gate region; other site 871585004833 ABC-ATPase subunit interface; other site 871585004834 hydroxyacylglutathione hydrolase; Region: GSH_gloB; TIGR03413 871585004835 C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663 871585004836 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 871585004837 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 871585004838 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 871585004839 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl17904 871585004840 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 871585004841 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 871585004842 Transcriptional regulator [Transcription]; Region: LysR; COG0583 871585004843 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 871585004844 The C-terminal substrate binding domain of LysR-type transcriptional regulators that are involved in the catabolism of dinitrotoluene, naphthalene and gamma-hexachlorohexane; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_NahR_LinR_like; cd08459 871585004845 substrate binding pocket [chemical binding]; other site 871585004846 dimerization interface [polypeptide binding]; other site 871585004847 benzoate transport; Region: 2A0115; TIGR00895 871585004848 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 871585004849 putative substrate translocation pore; other site 871585004850 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 871585004851 Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133 871585004852 Protein of unknown function (DUF1302); Region: DUF1302; pfam06980 871585004853 Serine hydrolase; Region: Ser_hydrolase; pfam06821 871585004854 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 871585004855 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 871585004856 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 871585004857 Predicted membrane protein [Function unknown]; Region: COG2855 871585004858 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 871585004859 iron-sulfur cluster [ion binding]; other site 871585004860 [2Fe-2S] cluster binding site [ion binding]; other site 871585004861 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 871585004862 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 871585004863 catalytic residues [active] 871585004864 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 871585004865 Major Facilitator Superfamily; Region: MFS_1; pfam07690 871585004866 putative substrate translocation pore; other site 871585004867 Prokaryotic protein of unknown function (DUF849); Region: DUF849; pfam05853 871585004868 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 871585004869 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 871585004870 quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754 871585004871 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 871585004872 NADP binding site [chemical binding]; other site 871585004873 dimer interface [polypeptide binding]; other site 871585004874 aspartate racemase; Region: asp_race; TIGR00035 871585004875 Aspartate racemase [Cell envelope biogenesis, outer membrane]; Region: RacX; COG1794 871585004876 SnoaL-like domain; Region: SnoaL_2; pfam12680 871585004877 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 871585004878 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 871585004879 active site 871585004880 phosphorylation site [posttranslational modification] 871585004881 intermolecular recognition site; other site 871585004882 dimerization interface [polypeptide binding]; other site 871585004883 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 871585004884 DNA binding site [nucleotide binding] 871585004885 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 871585004886 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 871585004887 dimer interface [polypeptide binding]; other site 871585004888 phosphorylation site [posttranslational modification] 871585004889 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 871585004890 ATP binding site [chemical binding]; other site 871585004891 Mg2+ binding site [ion binding]; other site 871585004892 G-X-G motif; other site 871585004893 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 871585004894 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 871585004895 S-adenosylmethionine binding site [chemical binding]; other site 871585004896 Protein of unknown function (DUF1295); Region: DUF1295; cl17837 871585004897 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 871585004898 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 871585004899 S-adenosylmethionine binding site [chemical binding]; other site 871585004900 Protein of unknown function (DUF1365); Region: DUF1365; pfam07103 871585004901 potential frameshift: common BLAST hit: gi|213158593|ref|YP_002319891.1| dehydrogenase 871585004902 Predicted NAD/FAD-binding protein [General function prediction only]; Region: COG2907 871585004903 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 871585004904 Fatty acid desaturase; Region: FA_desaturase; pfam00487 871585004905 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 871585004906 Di-iron ligands [ion binding]; other site 871585004907 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 871585004908 Lipocalin-like domain; Region: Lipocalin_2; pfam08212 871585004909 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 871585004910 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 871585004911 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 871585004912 dimer interface [polypeptide binding]; other site 871585004913 phosphorylation site [posttranslational modification] 871585004914 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 871585004915 ATP binding site [chemical binding]; other site 871585004916 Mg2+ binding site [ion binding]; other site 871585004917 G-X-G motif; other site 871585004918 heavy metal response regulator; Region: cztR_silR_copR; TIGR01387 871585004919 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 871585004920 active site 871585004921 phosphorylation site [posttranslational modification] 871585004922 intermolecular recognition site; other site 871585004923 dimerization interface [polypeptide binding]; other site 871585004924 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 871585004925 DNA binding site [nucleotide binding] 871585004926 Domain of unknown function (DUF336); Region: DUF336; pfam03928 871585004927 HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822 871585004928 active site 871585004929 homotetramer interface [polypeptide binding]; other site 871585004930 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 871585004931 Predicted transcriptional regulator [Transcription]; Region: COG1959 871585004932 Transcriptional regulator; Region: Rrf2; pfam02082 871585004933 Protein of unknown function (DUF330); Region: DUF330; pfam03886 871585004934 Paraquat-inducible protein B [General function prediction only]; Region: PqiB; COG3008 871585004935 mce related protein; Region: MCE; pfam02470 871585004936 mce related protein; Region: MCE; pfam02470 871585004937 mce related protein; Region: MCE; pfam02470 871585004938 Uncharacterized paraquat-inducible protein A [Function unknown]; Region: PqiA; COG2995 871585004939 Paraquat-inducible protein A; Region: PqiA; pfam04403 871585004940 Paraquat-inducible protein A; Region: PqiA; pfam04403 871585004941 aspartate-alanine antiporter; Region: Asp_Ala_antiprt; TIGR03802 871585004942 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 871585004943 TrkA-C domain; Region: TrkA_C; pfam02080 871585004944 TrkA-C domain; Region: TrkA_C; pfam02080 871585004945 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 871585004946 aspartate 4-decarboxylase; Region: asp_4_decarbox; TIGR03801 871585004947 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 871585004948 pyridoxal 5'-phosphate binding site [chemical binding]; other site 871585004949 homodimer interface [polypeptide binding]; other site 871585004950 catalytic residue [active] 871585004951 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 871585004952 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 871585004953 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 871585004954 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 871585004955 Kef-type K+ transport systems, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: Kch; COG1226 871585004956 TrkA-N domain; Region: TrkA_N; pfam02254 871585004957 Na+/glutamate symporter [Amino acid transport and metabolism]; Region: GltS; COG0786 871585004958 Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167 871585004959 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 871585004960 Sensors of blue-light using FAD; Region: BLUF; pfam04940 871585004961 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 871585004962 DNA-binding site [nucleotide binding]; DNA binding site 871585004963 RNA-binding motif; other site 871585004964 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 871585004965 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 871585004966 substrate binding site [chemical binding]; other site 871585004967 activation loop (A-loop); other site 871585004968 Domain of unknown function (DUF3336); Region: DUF3336; pfam11815 871585004969 Triacylglycerol lipase 3, 4, and 5 and Sugar-Dependent 1 lipase; Region: Pat_TGL3-4-5_SDP1; cd07206 871585004970 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 871585004971 active site 871585004972 nucleophile elbow; other site 871585004973 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG2607 871585004974 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 871585004975 Walker A motif; other site 871585004976 ATP binding site [chemical binding]; other site 871585004977 Walker B motif; other site 871585004978 UGMP family protein; Validated; Region: PRK09604 871585004979 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 871585004980 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 871585004981 Yqey-like protein; Region: YqeY; pfam09424 871585004982 Putative Zn-dependent protease, contains TPR repeats [General function prediction only]; Region: COG4783 871585004983 Peptidase family M48; Region: Peptidase_M48; cl12018 871585004984 bifunctional glyoxylate/hydroxypyruvate reductase B; Provisional; Region: PRK15409 871585004985 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 871585004986 dimerization interface [polypeptide binding]; other site 871585004987 ligand binding site [chemical binding]; other site 871585004988 NADP binding site [chemical binding]; other site 871585004989 catalytic site [active] 871585004990 Peptidase family M48; Region: Peptidase_M48; cl12018 871585004991 amidophosphoribosyltransferase; Provisional; Region: PRK09246 871585004992 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 871585004993 active site 871585004994 tetramer interface [polypeptide binding]; other site 871585004995 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 871585004996 active site 871585004997 Colicin V production protein; Region: Colicin_V; pfam02674 871585004998 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 871585004999 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 871585005000 quinone interaction residues [chemical binding]; other site 871585005001 active site 871585005002 catalytic residues [active] 871585005003 FMN binding site [chemical binding]; other site 871585005004 substrate binding site [chemical binding]; other site 871585005005 Type II secretion system (T2SS), protein M; Region: T2SM; cl01222 871585005006 Type II secretion system (T2SS), protein L; Region: T2SL; pfam05134 871585005007 GspL periplasmic domain; Region: GspL_C; cl14909 871585005008 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 871585005009 catalytic core [active] 871585005010 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 871585005011 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 871585005012 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 871585005013 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 871585005014 putative FMN binding site [chemical binding]; other site 871585005015 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 871585005016 DEAD-like helicases superfamily; Region: DEXDc; smart00487 871585005017 ATP binding site [chemical binding]; other site 871585005018 Mg++ binding site [ion binding]; other site 871585005019 motif III; other site 871585005020 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 871585005021 nucleotide binding region [chemical binding]; other site 871585005022 ATP-binding site [chemical binding]; other site 871585005023 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 871585005024 DNA-binding site [nucleotide binding]; DNA binding site 871585005025 RNA-binding motif; other site 871585005026 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cl00436 871585005027 RNA polymerase factor sigma-32; Reviewed; Region: PRK06596 871585005028 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 871585005029 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 871585005030 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 871585005031 DNA binding residues [nucleotide binding] 871585005032 Uncharacterized small membrane protein [Function unknown]; Region: COG2363 871585005033 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 871585005034 thiS-thiF/thiG interaction site; other site 871585005035 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 871585005036 ThiS interaction site; other site 871585005037 putative active site [active] 871585005038 tetramer interface [polypeptide binding]; other site 871585005039 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4339 871585005040 hypothetical protein; Validated; Region: PRK02101 871585005041 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2945 871585005042 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 871585005043 Xaa-His dipeptidase; Region: aa-his-dipept; TIGR01893 871585005044 M20 Peptidase D has specificity for beta-alanyl-L-histidine dipeptide; Region: M20_pepD; cd03890 871585005045 metal binding site [ion binding]; metal-binding site 871585005046 dimer interface [polypeptide binding]; other site 871585005047 bifunctional cyclohexadienyl dehydrogenase/ 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK14806 871585005048 prephenate dehydrogenase; Validated; Region: PRK08507 871585005049 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 871585005050 hinge; other site 871585005051 active site 871585005052 Chorismate mutase type II; Region: CM_2; cl00693 871585005053 Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077 871585005054 Prephenate dehydratase; Region: PDT; pfam00800 871585005055 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 871585005056 putative L-Phe binding site [chemical binding]; other site 871585005057 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 871585005058 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 871585005059 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 871585005060 active site 871585005061 C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663 871585005062 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 871585005063 hypothetical protein; Validated; Region: PRK09071 871585005064 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 871585005065 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 871585005066 Protein of unknown function (DUF1315); Region: DUF1315; pfam07023 871585005067 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02231 871585005068 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK01231 871585005069 penicillin-binding protein 1B; Region: PBP_1b; TIGR02071 871585005070 Transglycosylase; Region: Transgly; pfam00912 871585005071 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 871585005072 hypothetical protein; Provisional; Region: PRK08999 871585005073 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 871585005074 active site 871585005075 8-oxo-dGMP binding site [chemical binding]; other site 871585005076 nudix motif; other site 871585005077 metal binding site [ion binding]; metal-binding site 871585005078 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 871585005079 thiamine phosphate binding site [chemical binding]; other site 871585005080 active site 871585005081 Hemin uptake protein hemP; Region: hemP; cl10043 871585005082 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 871585005083 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 871585005084 dimer interface [polypeptide binding]; other site 871585005085 phosphorylation site [posttranslational modification] 871585005086 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 871585005087 ATP binding site [chemical binding]; other site 871585005088 Mg2+ binding site [ion binding]; other site 871585005089 G-X-G motif; other site 871585005090 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 871585005091 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 871585005092 active site 871585005093 phosphorylation site [posttranslational modification] 871585005094 intermolecular recognition site; other site 871585005095 dimerization interface [polypeptide binding]; other site 871585005096 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 871585005097 DNA binding site [nucleotide binding] 871585005098 Bacterial OB fold (BOF) protein; Region: BOF; cl01196 871585005099 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 871585005100 Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804 871585005101 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 871585005102 Walker A motif; other site 871585005103 ATP binding site [chemical binding]; other site 871585005104 Walker B motif; other site 871585005105 Predicted membrane protein [Function unknown]; Region: COG3174 871585005106 Domain of unknown function (DUF4010); Region: DUF4010; pfam13194 871585005107 Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281 871585005108 homodimer interaction site [polypeptide binding]; other site 871585005109 cofactor binding site; other site 871585005110 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 871585005111 Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195 871585005112 FAD binding pocket [chemical binding]; other site 871585005113 FAD binding motif [chemical binding]; other site 871585005114 phosphate binding motif [ion binding]; other site 871585005115 beta-alpha-beta structure motif; other site 871585005116 NAD binding pocket [chemical binding]; other site 871585005117 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 871585005118 hydroxyproline-2-epimerase; Provisional; Region: PRK13971 871585005119 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 871585005120 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 871585005121 DNA-binding site [nucleotide binding]; DNA binding site 871585005122 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 871585005123 pyridoxal 5'-phosphate binding site [chemical binding]; other site 871585005124 homodimer interface [polypeptide binding]; other site 871585005125 catalytic residue [active] 871585005126 putative protease; Provisional; Region: PRK15452 871585005127 Peptidase family U32; Region: Peptidase_U32; pfam01136 871585005128 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 871585005129 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 871585005130 ABC-type histidine transport system, ATPase component [Amino acid transport and metabolism]; Region: HisP; COG4598 871585005131 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 871585005132 Walker A/P-loop; other site 871585005133 ATP binding site [chemical binding]; other site 871585005134 Q-loop/lid; other site 871585005135 ABC transporter signature motif; other site 871585005136 Walker B; other site 871585005137 D-loop; other site 871585005138 H-loop/switch region; other site 871585005139 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 871585005140 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 871585005141 dimer interface [polypeptide binding]; other site 871585005142 conserved gate region; other site 871585005143 putative PBP binding loops; other site 871585005144 ABC-ATPase subunit interface; other site 871585005145 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 871585005146 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 871585005147 dimer interface [polypeptide binding]; other site 871585005148 conserved gate region; other site 871585005149 putative PBP binding loops; other site 871585005150 ABC-ATPase subunit interface; other site 871585005151 histidine ABC transporter substrate-binding protein HisJ; Provisional; Region: PRK15437 871585005152 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 871585005153 substrate binding pocket [chemical binding]; other site 871585005154 membrane-bound complex binding site; other site 871585005155 hinge residues; other site 871585005156 Transcriptional regulator [Transcription]; Region: LysR; COG0583 871585005157 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 871585005158 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 871585005159 putative effector binding pocket; other site 871585005160 putative dimerization interface [polypeptide binding]; other site 871585005161 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 871585005162 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 871585005163 HlyD family secretion protein; Region: HlyD_3; pfam13437 871585005164 AcrB/AcrD/AcrF family; Region: ACR_tran; pfam00873 871585005165 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 871585005166 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 871585005167 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 871585005168 dimer interface [polypeptide binding]; other site 871585005169 active site 871585005170 glycine-pyridoxal phosphate binding site [chemical binding]; other site 871585005171 folate binding site [chemical binding]; other site 871585005172 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 871585005173 Secretory lipase; Region: LIP; pfam03583 871585005174 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 871585005175 exodeoxyribonuclease X; Provisional; Region: PRK07983 871585005176 active site 871585005177 catalytic site [active] 871585005178 substrate binding site [chemical binding]; other site 871585005179 Protein of unknown function (DUF3820); Region: DUF3820; cl01411 871585005180 paraquat-inducible protein B; Provisional; Region: PRK10807 871585005181 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 871585005182 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 871585005183 Walker A/P-loop; other site 871585005184 ATP binding site [chemical binding]; other site 871585005185 Q-loop/lid; other site 871585005186 ABC transporter signature motif; other site 871585005187 Walker B; other site 871585005188 D-loop; other site 871585005189 H-loop/switch region; other site 871585005190 inner membrane transport permease; Provisional; Region: PRK15066 871585005191 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 871585005192 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2904 871585005193 7-cyano-7-deazaguanine reductase; Provisional; Region: queF; PRK11792 871585005194 Enzyme related to GTP cyclohydrolase I [General function prediction only]; Region: COG0780 871585005195 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 871585005196 Transglycosylase SLT domain; Region: SLT_2; pfam13406 871585005197 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 871585005198 N-acetyl-D-glucosamine binding site [chemical binding]; other site 871585005199 catalytic residue [active] 871585005200 Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797 871585005201 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 871585005202 Protein of unknown function (DUF962); Region: DUF962; cl01879 871585005203 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 871585005204 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 871585005205 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 871585005206 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 871585005207 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 871585005208 Protein of unknown function (DUF3465); Region: DUF3465; pfam11948 871585005209 elongation factor Ts; Provisional; Region: tsf; PRK09377 871585005210 UBA/TS-N domain; Region: UBA; pfam00627 871585005211 Elongation factor TS; Region: EF_TS; pfam00889 871585005212 Elongation factor TS; Region: EF_TS; pfam00889 871585005213 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 871585005214 rRNA interaction site [nucleotide binding]; other site 871585005215 S8 interaction site; other site 871585005216 putative laminin-1 binding site; other site 871585005217 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 871585005218 active site 871585005219 Outer membrane protein W [Cell envelope biogenesis, outer membrane]; Region: OmpW; COG3047 871585005220 nitrite extrusion protein (nitrite facilitator); Region: 2A0108; TIGR00886 871585005221 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 871585005222 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 871585005223 Major Facilitator Superfamily; Region: MFS_1; pfam07690 871585005224 putative substrate translocation pore; other site 871585005225 soluble pyridine nucleotide transhydrogenase; Provisional; Region: PRK05249 871585005226 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 871585005227 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 871585005228 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 871585005229 lipoyl synthase; Provisional; Region: PRK05481 871585005230 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 871585005231 FeS/SAM binding site; other site 871585005232 acyl-CoA dehydrogenase; Reviewed; Region: fadE; PRK09463 871585005233 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 871585005234 active site 871585005235 Domain of unknown function (DUF1974); Region: DUF1974; pfam09317 871585005236 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 871585005237 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 871585005238 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 871585005239 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 871585005240 homotetramer interface [polypeptide binding]; other site 871585005241 ligand binding site [chemical binding]; other site 871585005242 catalytic site [active] 871585005243 NAD binding site [chemical binding]; other site 871585005244 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 871585005245 FAD binding site [chemical binding]; other site 871585005246 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 871585005247 RNA methyltransferase, RsmE family; Region: TIGR00046 871585005248 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 871585005249 heme pocket [chemical binding]; other site 871585005250 putative active site [active] 871585005251 RNase II stability modulator; Provisional; Region: PRK10060 871585005252 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 871585005253 putative active site [active] 871585005254 heme pocket [chemical binding]; other site 871585005255 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 871585005256 metal binding site [ion binding]; metal-binding site 871585005257 active site 871585005258 I-site; other site 871585005259 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 871585005260 bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed; Region: PRK07232 871585005261 Malic enzyme, N-terminal domain; Region: malic; pfam00390 871585005262 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 871585005263 putative NAD(P) binding site [chemical binding]; other site 871585005264 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 871585005265 multifunctional tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase; Reviewed; Region: cca; PRK10885 871585005266 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 871585005267 active site 871585005268 NTP binding site [chemical binding]; other site 871585005269 metal binding triad [ion binding]; metal-binding site 871585005270 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 871585005271 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 871585005272 Zn2+ binding site [ion binding]; other site 871585005273 Mg2+ binding site [ion binding]; other site 871585005274 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 871585005275 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 871585005276 protein binding site [polypeptide binding]; other site 871585005277 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371 871585005278 Uncharacterized conserved protein [Function unknown]; Region: COG0327 871585005279 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 871585005280 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 871585005281 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 871585005282 Protein of unknown function (DUF2726); Region: DUF2726; pfam10881 871585005283 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 871585005284 4-hydroxybenzoate octaprenyltransferase; Reviewed; Region: ubiA; PRK12848 871585005285 UbiA prenyltransferase family; Region: UbiA; pfam01040 871585005286 Chorismate lyase; Region: Chor_lyase; cl01230 871585005287 glutamine synthetase; Provisional; Region: glnA; PRK09469 871585005288 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 871585005289 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 871585005290 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 871585005291 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 871585005292 putative substrate translocation pore; other site 871585005293 POT family; Region: PTR2; cl17359 871585005294 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 871585005295 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 871585005296 X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP; cd01085 871585005297 active site 871585005298 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 871585005299 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 871585005300 glutamine binding [chemical binding]; other site 871585005301 catalytic triad [active] 871585005302 Peptidase family M1; Region: Peptidase_M1; pfam01433 871585005303 Peptidase M1 Aminopeptidase N family incudes tricorn interacting factor F3, Endoplasmic reticulum aminopeptidase 1 (ERAP1), Aminopeptidase Q (APQ); Region: M1_APN_2; cd09601 871585005304 Zn binding site [ion binding]; other site 871585005305 Domain of unknown function (DUF3358); Region: DUF3358; pfam11838 871585005306 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 871585005307 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 871585005308 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 871585005309 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 871585005310 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 871585005311 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 871585005312 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 871585005313 active site 871585005314 ribulose/triose binding site [chemical binding]; other site 871585005315 phosphate binding site [ion binding]; other site 871585005316 substrate (anthranilate) binding pocket [chemical binding]; other site 871585005317 product (indole) binding pocket [chemical binding]; other site 871585005318 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2840 871585005319 Smr domain; Region: Smr; pfam01713 871585005320 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 871585005321 xanthine dehydrogenase accessory protein XdhC; Region: xanthine_xdhC; TIGR02964 871585005322 XdhC Rossmann domain; Region: XdhC_C; pfam13478 871585005323 xanthine dehydrogenase, molybdopterin binding subunit; Region: xanthine_xdhB; TIGR02965 871585005324 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 871585005325 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 871585005326 xanthine dehydrogenase, small subunit; Region: xanthine_xdhA; TIGR02963 871585005327 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 871585005328 catalytic loop [active] 871585005329 iron binding site [ion binding]; other site 871585005330 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 871585005331 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450 871585005332 GTP cyclohydrolase I; Provisional; Region: PLN03044 871585005333 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 871585005334 homodecamer interface [polypeptide binding]; other site 871585005335 active site 871585005336 putative catalytic site residues [active] 871585005337 zinc binding site [ion binding]; other site 871585005338 GTP-CH-I/GFRP interaction surface; other site 871585005339 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 871585005340 beta-lactamase/D-alanine carboxypeptidase; Provisional; Region: ampC; PRK11289 871585005341 Domain of unknown function (DUF4105); Region: DUF4105; pfam13387 871585005342 Protein of unknown function (DUF3015); Region: DUF3015; pfam11220 871585005343 Protein of unknown function (DUF817); Region: DUF817; pfam05675 871585005344 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 871585005345 substrate binding site [chemical binding]; other site 871585005346 active site 871585005347 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 871585005348 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 871585005349 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 871585005350 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 871585005351 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 871585005352 Phosphopantetheinyl transferase component of siderophore synthetase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntD; COG2977 871585005353 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 871585005354 Thioesterase domain; Region: Thioesterase; pfam00975 871585005355 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 871585005356 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 871585005357 Walker A/P-loop; other site 871585005358 ATP binding site [chemical binding]; other site 871585005359 Q-loop/lid; other site 871585005360 ABC transporter signature motif; other site 871585005361 Walker B; other site 871585005362 D-loop; other site 871585005363 H-loop/switch region; other site 871585005364 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 871585005365 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 871585005366 Walker A/P-loop; other site 871585005367 ATP binding site [chemical binding]; other site 871585005368 Q-loop/lid; other site 871585005369 ABC transporter signature motif; other site 871585005370 Walker B; other site 871585005371 D-loop; other site 871585005372 H-loop/switch region; other site 871585005373 potential frameshift: common BLAST hit: gi|184158896|ref|YP_001847235.1| histidine decarboxylase 871585005374 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 871585005375 histidine decarboxylase; Provisional; Region: PRK02769 871585005376 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 871585005377 catalytic residue [active] 871585005378 Isochorismatase, also known as 2,3 dihydro-2,3 dihydroxybenzoate synthase, catalyses the conversion of isochorismate, in the presence of water, to 2,3-dihydroxybenzoate and pyruvate, via the hydrolysis of a vinyl ether, an uncommon reaction in biological...; Region: isochorismatase; cd01013 871585005379 hydrophobic substrate binding pocket; other site 871585005380 Isochorismatase family; Region: Isochorismatase; pfam00857 871585005381 active site 871585005382 conserved cis-peptide bond; other site 871585005383 Aryl carrier domain [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3433 871585005384 enterobactin synthase subunit E; Provisional; Region: entE; PRK10946 871585005385 2,3-dihydroxybenzoate-AMP ligase; Region: 23DHB-AMP_lg; cd05920 871585005386 acyl-activating enzyme (AAE) consensus motif; other site 871585005387 active site 871585005388 AMP binding site [chemical binding]; other site 871585005389 substrate binding site [chemical binding]; other site 871585005390 Condensation domain; Region: Condensation; pfam00668 871585005391 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 871585005392 Nonribosomal peptide synthase; Region: NRPS; pfam08415 871585005393 Condensation domain; Region: Condensation; pfam00668 871585005394 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 871585005395 Nonribosomal peptide synthase; Region: NRPS; pfam08415 871585005396 Lysine/ornithine N-monooxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: IucD; COG3486 871585005397 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 871585005398 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 871585005399 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 871585005400 N-terminal plug; other site 871585005401 ligand-binding site [chemical binding]; other site 871585005402 ABC-type enterochelin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: CeuA; COG4607 871585005403 Siderophore binding protein FatB. These proteins have been shown to function as ABC-type initial receptors in the siderophore-mediated iron uptake in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins...; Region: FatB; cd01140 871585005404 putative ligand binding residues [chemical binding]; other site 871585005405 ABC-type enterochelin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CeuD; COG4604 871585005406 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 871585005407 Walker A/P-loop; other site 871585005408 ATP binding site [chemical binding]; other site 871585005409 Q-loop/lid; other site 871585005410 ABC transporter signature motif; other site 871585005411 Walker B; other site 871585005412 D-loop; other site 871585005413 H-loop/switch region; other site 871585005414 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 871585005415 ABC-ATPase subunit interface; other site 871585005416 dimer interface [polypeptide binding]; other site 871585005417 putative PBP binding regions; other site 871585005418 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 871585005419 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 871585005420 ABC-ATPase subunit interface; other site 871585005421 dimer interface [polypeptide binding]; other site 871585005422 putative PBP binding regions; other site 871585005423 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 871585005424 Condensation domain; Region: Condensation; pfam00668 871585005425 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 871585005426 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; Region: A_NRPS_TlmIV_like; cd12114 871585005427 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 871585005428 acyl-activating enzyme (AAE) consensus motif; other site 871585005429 AMP binding site [chemical binding]; other site 871585005430 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 871585005431 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 871585005432 FAD binding pocket [chemical binding]; other site 871585005433 FAD binding motif [chemical binding]; other site 871585005434 phosphate binding motif [ion binding]; other site 871585005435 NAD binding pocket [chemical binding]; other site 871585005436 Pirin-related protein [General function prediction only]; Region: COG1741 871585005437 Pirin; Region: Pirin; pfam02678 871585005438 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 871585005439 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 871585005440 Protein of unknown function (DUF466); Region: DUF466; pfam04328 871585005441 carbon starvation protein A; Provisional; Region: PRK15015 871585005442 Carbon starvation protein CstA; Region: CstA; pfam02554 871585005443 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 871585005444 elongation factor P; Validated; Region: PRK00529 871585005445 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 871585005446 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 871585005447 RNA binding site [nucleotide binding]; other site 871585005448 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 871585005449 RNA binding site [nucleotide binding]; other site 871585005450 potential frameshift: common BLAST hit: gi|215482748|ref|YP_002324946.1| L-lysine 2,3-aminomutase(KAM) (LAM) 871585005451 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377 871585005452 Radical SAM superfamily; Region: Radical_SAM; pfam04055 871585005453 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 871585005454 FeS/SAM binding site; other site 871585005455 PAS domain S-box; Region: sensory_box; TIGR00229 871585005456 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 871585005457 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 871585005458 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 871585005459 SBF-like CPA transporter family (DUF4137); Region: DUF4137; pfam13593 871585005460 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 871585005461 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 871585005462 dimer interface [polypeptide binding]; other site 871585005463 active site 871585005464 glutathione binding site [chemical binding]; other site 871585005465 muropeptide transporter; Validated; Region: ampG; cl17669 871585005466 muropeptide transporter; Validated; Region: ampG; cl17669 871585005467 muropeptide transporter; Validated; Region: ampG; cl17669 871585005468 AAA domain; Region: AAA_32; pfam13654 871585005469 lon-related putative ATP-dependent protease; Region: lon_rel; TIGR00764 871585005470 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 871585005471 Transcriptional regulator [Transcription]; Region: LysR; COG0583 871585005472 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 871585005473 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 871585005474 putative effector binding pocket; other site 871585005475 dimerization interface [polypeptide binding]; other site 871585005476 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 871585005477 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 871585005478 Peptidase family M23; Region: Peptidase_M23; pfam01551 871585005479 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 871585005480 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 871585005481 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 871585005482 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 871585005483 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 871585005484 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 871585005485 trimer interface [polypeptide binding]; other site 871585005486 putative metal binding site [ion binding]; other site 871585005487 Contains a crystal structure of the Nudix hydrolase from Nitrosomonas europaea, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_2; cd03675 871585005488 nudix motif; other site 871585005489 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 871585005490 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 871585005491 putative lysogenization regulator; Reviewed; Region: PRK00218 871585005492 adenylosuccinate lyase; Provisional; Region: PRK09285 871585005493 PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598 871585005494 tetramer interface [polypeptide binding]; other site 871585005495 active site 871585005496 Predicted membrane protein (DUF2238); Region: DUF2238; pfam09997 871585005497 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 871585005498 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 871585005499 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 871585005500 tandem repeat interface [polypeptide binding]; other site 871585005501 oligomer interface [polypeptide binding]; other site 871585005502 active site residues [active] 871585005503 phosphate transporter ATP-binding protein; Provisional; Region: PRK14235 871585005504 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 871585005505 Walker A/P-loop; other site 871585005506 ATP binding site [chemical binding]; other site 871585005507 Q-loop/lid; other site 871585005508 ABC transporter signature motif; other site 871585005509 Walker B; other site 871585005510 D-loop; other site 871585005511 H-loop/switch region; other site 871585005512 Domain of unknown function (DUF3333); Region: DUF3333; pfam11812 871585005513 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 871585005514 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 871585005515 dimer interface [polypeptide binding]; other site 871585005516 conserved gate region; other site 871585005517 putative PBP binding loops; other site 871585005518 ABC-ATPase subunit interface; other site 871585005519 Phosphate ATP-binding cassette transporter; Region: DUF3708; pfam12501 871585005520 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 871585005521 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 871585005522 dimer interface [polypeptide binding]; other site 871585005523 conserved gate region; other site 871585005524 putative PBP binding loops; other site 871585005525 ABC-ATPase subunit interface; other site 871585005526 ABC-type phosphate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PstS; COG0226 871585005527 aromatic amino acid transporter; Provisional; Region: PRK10238 871585005528 Pyruvate decarboxylase and related thiamine pyrophosphate-requiring enzymes [Carbohydrate transport and metabolism / Coenzyme metabolism / General function prediction only]; Region: COG3961 871585005529 Pyrimidine (PYR) binding domain of pyruvate decarboxylase (PDC), indolepyruvate decarboxylase (IPDC) and related proteins; Region: TPP_PYR_PDC_IPDC_like; cd07038 871585005530 dimer interface [polypeptide binding]; other site 871585005531 PYR/PP interface [polypeptide binding]; other site 871585005532 TPP binding site [chemical binding]; other site 871585005533 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 871585005534 Thiamine pyrophosphate (TPP) family, PDC_IPDC subfamily, TPP-binding module; composed of proteins similar to pyruvate decarboxylase (PDC) and indolepyruvate decarboxylase (IPDC). PDC, a key enzyme in alcoholic fermentation, catalyzes the conversion of...; Region: TPP_PDC_IPDC; cd02005 871585005535 TPP-binding site [chemical binding]; other site 871585005536 dimer interface [polypeptide binding]; other site 871585005537 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 871585005538 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 871585005539 putative DNA binding site [nucleotide binding]; other site 871585005540 putative Zn2+ binding site [ion binding]; other site 871585005541 AsnC family; Region: AsnC_trans_reg; pfam01037 871585005542 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 871585005543 Streptomyces aureofaciens putative aldehyde dehydrogenase AldA (AAD23400)-like; Region: ALDH_AldA-AAD23400; cd07106 871585005544 NAD(P) binding site [chemical binding]; other site 871585005545 catalytic residues [active] 871585005546 DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450 871585005547 pyridoxal 5'-phosphate binding site [chemical binding]; other site 871585005548 catalytic residue [active] 871585005549 diaminobutyrate--2-oxoglutarate aminotransferase; Provisional; Region: PRK06931 871585005550 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 871585005551 inhibitor-cofactor binding pocket; inhibition site 871585005552 pyridoxal 5'-phosphate binding site [chemical binding]; other site 871585005553 catalytic residue [active] 871585005554 Protein of unknown function (DUF541); Region: SIMPL; cl01077 871585005555 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 871585005556 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 871585005557 putative di-iron ligands [ion binding]; other site 871585005558 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_2; cd06216 871585005559 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 871585005560 FAD binding pocket [chemical binding]; other site 871585005561 FAD binding motif [chemical binding]; other site 871585005562 phosphate binding motif [ion binding]; other site 871585005563 beta-alpha-beta structure motif; other site 871585005564 NAD binding pocket [chemical binding]; other site 871585005565 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 871585005566 catalytic loop [active] 871585005567 iron binding site [ion binding]; other site 871585005568 DNA-binding transcriptional repressor FabR; Provisional; Region: PRK11202 871585005569 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 871585005570 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465 871585005571 ATP-dependent helicase HepA; Validated; Region: PRK04914 871585005572 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 871585005573 ATP binding site [chemical binding]; other site 871585005574 putative Mg++ binding site [ion binding]; other site 871585005575 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 871585005576 nucleotide binding region [chemical binding]; other site 871585005577 ATP-binding site [chemical binding]; other site 871585005578 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 871585005579 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 871585005580 active site 871585005581 Phosphopantetheine attachment site; Region: PP-binding; cl09936 871585005582 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 871585005583 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 871585005584 inhibitor-cofactor binding pocket; inhibition site 871585005585 pyridoxal 5'-phosphate binding site [chemical binding]; other site 871585005586 catalytic residue [active] 871585005587 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 871585005588 thiamine phosphate binding site [chemical binding]; other site 871585005589 active site 871585005590 pyrophosphate binding site [ion binding]; other site 871585005591 Protein of unknown function (DUF962); Region: DUF962; pfam06127 871585005592 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK11194 871585005593 Uncharacterized subgroup of the CYTH-like superfamily having an associated CHAD domain; Region: CYTH-like_Pase_CHAD; cd07756 871585005594 putative active site [active] 871585005595 putative triphosphate binding site [ion binding]; other site 871585005596 putative metal binding residues [ion binding]; other site 871585005597 The CHAD domain is an alpha-helical domain functionally associated with some members of the adenylate cyclase family; Region: CHAD; smart00880 871585005598 Protein of unknown function (DUF3144); Region: DUF3144; pfam11342 871585005599 potential frameshift: common BLAST hit: gi|299769203|ref|YP_003731229.1| protease 871585005600 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 871585005601 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 871585005602 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 871585005603 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 871585005604 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 871585005605 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 871585005606 Predicted Na+/dicarboxylate symporter [General function prediction only]; Region: COG1823 871585005607 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 871585005608 Transcriptional regulator [Transcription]; Region: LysR; COG0583 871585005609 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 871585005610 The C-terminal substrate binding domain of LysR-type transcriptional regulators, YofA and SoxR, contains the type 2 periplasmic binding fold; Region: PBP2_YofA_SoxR_like; cd08442 871585005611 putative dimerization interface [polypeptide binding]; other site 871585005612 Protein of unknown function (DUF1228); Region: DUF1228; pfam06779 871585005613 isocitrate dehydrogenase; Validated; Region: PRK07362 871585005614 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 871585005615 Pseudouridine synthase, Escherichia coli RluE; Region: PseudoU_synth_RluE; cd02566 871585005616 pseudouridine synthase; Region: TIGR00093 871585005617 probable active site [active] 871585005618 potential frameshift: common BLAST hit: gi|184159009|ref|YP_001847348.1| monomeric isocitrate dehydrogenase 871585005619 Monomeric isocitrate dehydrogenase; Region: IDH; cl15383 871585005620 potential frameshift: common BLAST hit: gi|299769195|ref|YP_003731221.1| isocitrate dehydrogenase, NADP-dependent 871585005621 Monomeric isocitrate dehydrogenase; Region: IDH; cl15383 871585005622 Monomeric isocitrate dehydrogenase; Region: IDH; cl15383 871585005623 Predicted protease with the C-terminal PDZ domain [General function prediction only]; Region: COG3975 871585005624 M61 glycyl aminopeptidase; Region: Peptidase_M61; pfam05299 871585005625 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 871585005626 protein binding site [polypeptide binding]; other site 871585005627 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 871585005628 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 871585005629 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 871585005630 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 871585005631 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095 871585005632 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 871585005633 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 871585005634 DNA photolyase; Region: DNA_photolyase; pfam00875 871585005635 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 871585005636 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 871585005637 DXD motif; other site 871585005638 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 871585005639 TPR motif; other site 871585005640 binding surface 871585005641 Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_1; cd02432 871585005642 Nitronate monooxygenase; Region: NMO; pfam03060 871585005643 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 871585005644 FMN binding site [chemical binding]; other site 871585005645 substrate binding site [chemical binding]; other site 871585005646 putative catalytic residue [active] 871585005647 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 871585005648 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 871585005649 FMN binding site [chemical binding]; other site 871585005650 active site 871585005651 catalytic residues [active] 871585005652 substrate binding site [chemical binding]; other site 871585005653 Protein of unknown function (DUF1615); Region: DUF1615; pfam07759 871585005654 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 871585005655 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 871585005656 gamma-glutamyl kinase; Provisional; Region: PRK05429 871585005657 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 871585005658 nucleotide binding site [chemical binding]; other site 871585005659 homotetrameric interface [polypeptide binding]; other site 871585005660 putative phosphate binding site [ion binding]; other site 871585005661 putative allosteric binding site; other site 871585005662 PUA domain; Region: PUA; pfam01472 871585005663 GTPase CgtA; Reviewed; Region: obgE; PRK12298 871585005664 GTP1/OBG; Region: GTP1_OBG; pfam01018 871585005665 Obg GTPase; Region: Obg; cd01898 871585005666 G1 box; other site 871585005667 GTP/Mg2+ binding site [chemical binding]; other site 871585005668 Switch I region; other site 871585005669 G2 box; other site 871585005670 G3 box; other site 871585005671 Switch II region; other site 871585005672 G4 box; other site 871585005673 G5 box; other site 871585005674 glyceraldehyde-3-phosphate dehydrogenase; Reviewed; Region: PRK08289 871585005675 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 871585005676 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 871585005677 Predicted permeases [General function prediction only]; Region: RarD; COG2962 871585005678 Lipocalin-like domain; Region: Lipocalin_2; pfam08212 871585005679 excinuclease ABC subunit B; Provisional; Region: PRK05298 871585005680 Myosin and Kinesin motor domain. These ATPases belong to the P-loop NTPase family and provide the driving force in myosin and kinesin mediated processes; Region: Motor_domain; cl00286 871585005681 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 871585005682 ATP-binding site [chemical binding]; other site 871585005683 ATP binding site [chemical binding]; other site 871585005684 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 871585005685 nucleotide binding region [chemical binding]; other site 871585005686 ATP-binding site [chemical binding]; other site 871585005687 Ultra-violet resistance protein B; Region: UvrB; pfam12344 871585005688 UvrB/uvrC motif; Region: UVR; pfam02151 871585005689 hypothetical protein; Region: PHA00684 871585005690 PAS domain; Region: PAS_9; pfam13426 871585005691 PAS domain; Region: PAS_9; pfam13426 871585005692 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 871585005693 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 871585005694 metal binding site [ion binding]; metal-binding site 871585005695 active site 871585005696 I-site; other site 871585005697 aspartate aminotransferase; Provisional; Region: PRK05764 871585005698 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 871585005699 pyridoxal 5'-phosphate binding site [chemical binding]; other site 871585005700 homodimer interface [polypeptide binding]; other site 871585005701 catalytic residue [active] 871585005702 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 871585005703 EamA-like transporter family; Region: EamA; pfam00892 871585005704 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 871585005705 CoenzymeA binding site [chemical binding]; other site 871585005706 subunit interaction site [polypeptide binding]; other site 871585005707 PHB binding site; other site 871585005708 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 871585005709 malonic semialdehyde reductase; Provisional; Region: PRK10538 871585005710 NAD(P) binding site [chemical binding]; other site 871585005711 active site 871585005712 MiaE tRNA-modifying nonheme diiron monooxygenase, ferritin-like diiron-binding domain; Region: MiaE; cd07910 871585005713 active site 871585005714 dinuclear metal binding site [ion binding]; other site 871585005715 dimerization interface [polypeptide binding]; other site 871585005716 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003 871585005717 active site 871585005718 hydrophilic channel; other site 871585005719 dimerization interface [polypeptide binding]; other site 871585005720 catalytic residues [active] 871585005721 active site lid [active] 871585005722 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 871585005723 Recombination protein O N terminal; Region: RecO_N; pfam11967 871585005724 Recombination protein O C terminal; Region: RecO_C; pfam02565 871585005725 GTPase Era; Reviewed; Region: era; PRK00089 871585005726 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 871585005727 G1 box; other site 871585005728 GTP/Mg2+ binding site [chemical binding]; other site 871585005729 Switch I region; other site 871585005730 G2 box; other site 871585005731 Switch II region; other site 871585005732 G3 box; other site 871585005733 G4 box; other site 871585005734 G5 box; other site 871585005735 KH domain; Region: KH_2; pfam07650 871585005736 ribonuclease III; Reviewed; Region: rnc; PRK00102 871585005737 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 871585005738 dimerization interface [polypeptide binding]; other site 871585005739 metal binding site [ion binding]; metal-binding site 871585005740 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 871585005741 dsRNA binding site [nucleotide binding]; other site 871585005742 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 871585005743 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 871585005744 Catalytic site [active] 871585005745 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 871585005746 GTP-binding protein LepA; Provisional; Region: PRK05433 871585005747 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 871585005748 G1 box; other site 871585005749 putative GEF interaction site [polypeptide binding]; other site 871585005750 GTP/Mg2+ binding site [chemical binding]; other site 871585005751 Switch I region; other site 871585005752 G2 box; other site 871585005753 G3 box; other site 871585005754 Switch II region; other site 871585005755 G4 box; other site 871585005756 G5 box; other site 871585005757 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 871585005758 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 871585005759 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 871585005760 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 871585005761 active site 871585005762 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 871585005763 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 871585005764 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 871585005765 protein binding site [polypeptide binding]; other site 871585005766 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 871585005767 protein binding site [polypeptide binding]; other site 871585005768 L-aspartate oxidase; Provisional; Region: PRK09077 871585005769 L-aspartate oxidase; Provisional; Region: PRK06175 871585005770 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 871585005771 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 871585005772 CoenzymeA binding site [chemical binding]; other site 871585005773 subunit interaction site [polypeptide binding]; other site 871585005774 PHB binding site; other site 871585005775 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 871585005776 thymidylate kinase; Validated; Region: tmk; PRK00698 871585005777 TMP-binding site; other site 871585005778 ATP-binding site [chemical binding]; other site 871585005779 YceG-like family; Region: YceG; pfam02618 871585005780 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 871585005781 dimerization interface [polypeptide binding]; other site 871585005782 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 871585005783 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 871585005784 pyridoxal 5'-phosphate binding site [chemical binding]; other site 871585005785 catalytic residue [active] 871585005786 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 871585005787 substrate binding pocket [chemical binding]; other site 871585005788 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 871585005789 membrane-bound complex binding site; other site 871585005790 hinge residues; other site 871585005791 Serine hydrolase; Region: Ser_hydrolase; pfam06821 871585005792 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 871585005793 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 871585005794 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 871585005795 dimer interface [polypeptide binding]; other site 871585005796 conserved gate region; other site 871585005797 putative PBP binding loops; other site 871585005798 ABC-ATPase subunit interface; other site 871585005799 sulfate transport protein; Provisional; Region: cysT; CHL00187 871585005800 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 871585005801 dimer interface [polypeptide binding]; other site 871585005802 conserved gate region; other site 871585005803 putative PBP binding loops; other site 871585005804 ABC-ATPase subunit interface; other site 871585005805 ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118 871585005806 ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296 871585005807 Walker A/P-loop; other site 871585005808 ATP binding site [chemical binding]; other site 871585005809 Q-loop/lid; other site 871585005810 ABC transporter signature motif; other site 871585005811 Walker B; other site 871585005812 D-loop; other site 871585005813 H-loop/switch region; other site 871585005814 TOBE-like domain; Region: TOBE_3; pfam12857 871585005815 transcriptional regulator CysB-like protein; Reviewed; Region: PRK12683 871585005816 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 871585005817 The C-terminal substrate domain of LysR-type transcriptional regulators CysB-like contains type 2 periplasmic binding fold; Region: PBP2_CysB_like; cd08413 871585005818 substrate binding site [chemical binding]; other site 871585005819 dimerization interface [polypeptide binding]; other site 871585005820 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830 871585005821 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 871585005822 active site 871585005823 substrate binding site [chemical binding]; other site 871585005824 trimer interface [polypeptide binding]; other site 871585005825 CoA binding site [chemical binding]; other site 871585005826 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE, gammaproteobacterial type; Region: rSAM_QueE_gams; TIGR04349 871585005827 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 871585005828 FeS/SAM binding site; other site 871585005829 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 871585005830 Ligand Binding Site [chemical binding]; other site 871585005831 Predicted ATPases of PP-loop superfamily [General function prediction only]; Region: COG2102 871585005832 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_IV; cd01994 871585005833 Ligand Binding Site [chemical binding]; other site 871585005834 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 871585005835 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 871585005836 catalytic triad [active] 871585005837 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 871585005838 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 871585005839 Bleomycin binding protein (BLMA) and similar proteins; BLMA confers bleomycin (Bm) resistance by directly binding to Bm; Region: BLMA_like; cd08349 871585005840 dimer interface [polypeptide binding]; other site 871585005841 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 871585005842 ligand binding site [chemical binding]; other site 871585005843 nicotinamide-nucleotide adenylyltransferase; Provisional; Region: PRK13793 871585005844 active site 871585005845 nucleotide binding site [chemical binding]; other site 871585005846 HIGH motif; other site 871585005847 KMSKS motif; other site 871585005848 enoyl-CoA hydratase; Provisional; Region: PRK06688 871585005849 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 871585005850 substrate binding site [chemical binding]; other site 871585005851 oxyanion hole (OAH) forming residues; other site 871585005852 trimer interface [polypeptide binding]; other site 871585005853 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762 871585005854 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 871585005855 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 871585005856 putative substrate translocation pore; other site 871585005857 phosphoribosylformylglycinamidine synthase; Provisional; Region: PRK05297 871585005858 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 871585005859 dimerization interface [polypeptide binding]; other site 871585005860 ATP binding site [chemical binding]; other site 871585005861 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 871585005862 dimerization interface [polypeptide binding]; other site 871585005863 ATP binding site [chemical binding]; other site 871585005864 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 871585005865 putative active site [active] 871585005866 catalytic triad [active] 871585005867 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01096 871585005868 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 871585005869 Zn2+ binding site [ion binding]; other site 871585005870 Mg2+ binding site [ion binding]; other site 871585005871 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 871585005872 RuvA N terminal domain; Region: RuvA_N; pfam01330 871585005873 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 871585005874 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 871585005875 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 871585005876 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 871585005877 Walker A motif; other site 871585005878 ATP binding site [chemical binding]; other site 871585005879 Walker B motif; other site 871585005880 arginine finger; other site 871585005881 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 871585005882 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like2; cd05667 871585005883 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 871585005884 metal binding site [ion binding]; metal-binding site 871585005885 putative dimer interface [polypeptide binding]; other site 871585005886 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 871585005887 active site 871585005888 TolQ protein; Region: tolQ; TIGR02796 871585005889 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 871585005890 TolR protein; Region: tolR; TIGR02801 871585005891 potential frameshift: common BLAST hit: gi|299769116|ref|YP_003731142.1| group A colicins tolerance protein 871585005892 TolA protein; Region: tolA_full; TIGR02794 871585005893 translocation protein TolB; Provisional; Region: tolB; PRK04922 871585005894 TolB amino-terminal domain; Region: TolB_N; pfam04052 871585005895 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 871585005896 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 871585005897 peptidoglycan-associated outer membrane lipoprotein; Provisional; Region: PRK10802 871585005898 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 871585005899 ligand binding site [chemical binding]; other site 871585005900 fructose-1,6-bisphosphatase family protein; Region: PLN02628 871585005901 Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354 871585005902 AMP binding site [chemical binding]; other site 871585005903 metal binding site [ion binding]; metal-binding site 871585005904 active site 871585005905 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 871585005906 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 871585005907 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 871585005908 RNA polymerase factor sigma-70; Validated; Region: PRK09047 871585005909 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 871585005910 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 871585005911 DNA binding residues [nucleotide binding] 871585005912 Protein of unknown function (DUF3106); Region: DUF3106; pfam11304 871585005913 CSLREA domain; Region: CSLREA_Nterm; TIGR04214 871585005914 Acinetobacter rhombotarget A; Region: GlyGly_RbtA; TIGR04212 871585005915 ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593 871585005916 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 871585005917 Walker A motif; other site 871585005918 ATP binding site [chemical binding]; other site 871585005919 Walker B motif; other site 871585005920 arginine finger; other site 871585005921 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 871585005922 Domain of unknown function DUF20; Region: UPF0118; pfam01594 871585005923 potential frameshift: common BLAST hit: gi|215482596|ref|YP_002324788.1| phosphoribosylaminoimidazole synthetase 871585005924 AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019 871585005925 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 871585005926 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 871585005927 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 871585005928 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 871585005929 active site 871585005930 substrate binding site [chemical binding]; other site 871585005931 cosubstrate binding site; other site 871585005932 catalytic site [active] 871585005933 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 871585005934 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 871585005935 tandem repeat interface [polypeptide binding]; other site 871585005936 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 871585005937 oligomer interface [polypeptide binding]; other site 871585005938 active site residues [active] 871585005939 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 871585005940 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 871585005941 putative acyl-acceptor binding pocket; other site 871585005942 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 871585005943 DNA internalization-related competence protein ComEC/Rec2; Region: ComEC_Rec2; TIGR00361 871585005944 Competence protein; Region: Competence; pfam03772 871585005945 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 871585005946 lipoprotein releasing system, ATP-binding protein; Region: LolD_lipo_ex; TIGR02211 871585005947 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 871585005948 Walker A/P-loop; other site 871585005949 ATP binding site [chemical binding]; other site 871585005950 Q-loop/lid; other site 871585005951 ABC transporter signature motif; other site 871585005952 Walker B; other site 871585005953 D-loop; other site 871585005954 H-loop/switch region; other site 871585005955 lipoprotein releasing system, transmembrane protein, LolC/E family; Region: lolCE; TIGR02212 871585005956 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 871585005957 FtsX-like permease family; Region: FtsX; pfam02687 871585005958 putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272 871585005959 EamA-like transporter family; Region: EamA; pfam00892 871585005960 Uncharacterized BCR, YaiI/YqxD family COG1671; Region: DUF188; pfam02639 871585005961 Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT). PSAT is active as...; Region: PSAT_like; cd00611 871585005962 homodimer interface [polypeptide binding]; other site 871585005963 substrate-cofactor binding pocket; other site 871585005964 pyridoxal 5'-phosphate binding site [chemical binding]; other site 871585005965 catalytic residue [active] 871585005966 Outer membrane efflux protein; Region: OEP; pfam02321 871585005967 Outer membrane efflux protein; Region: OEP; pfam02321 871585005968 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 871585005969 HlyD family secretion protein; Region: HlyD_3; pfam13437 871585005970 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 871585005971 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 871585005972 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 871585005973 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 871585005974 DNA gyrase subunit A; Validated; Region: PRK05560 871585005975 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 871585005976 CAP-like domain; other site 871585005977 active site 871585005978 primary dimer interface [polypeptide binding]; other site 871585005979 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 871585005980 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 871585005981 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 871585005982 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 871585005983 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 871585005984 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 871585005985 potential frameshift: common BLAST hit: gi|184159190|ref|YP_001847529.1| electron transfer flavoprotein subunit alpha 871585005986 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 871585005987 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 871585005988 Electron transfer flavoprotein domain; Region: ETF; pfam01012 871585005989 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 871585005990 Ligand binding site [chemical binding]; other site 871585005991 Electron transfer flavoprotein domain; Region: ETF; pfam01012 871585005992 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 871585005993 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 871585005994 active site 871585005995 DNA binding site [nucleotide binding] 871585005996 Int/Topo IB signature motif; other site 871585005997 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 871585005998 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 871585005999 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 871585006000 catalytic site [active] 871585006001 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 871585006002 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 871585006003 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 871585006004 diaminopimelate decarboxylase; Region: lysA; TIGR01048 871585006005 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 871585006006 active site 871585006007 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 871585006008 substrate binding site [chemical binding]; other site 871585006009 catalytic residues [active] 871585006010 dimer interface [polypeptide binding]; other site 871585006011 D-alanine/D-serine/glycine permease; Provisional; Region: PRK11049 871585006012 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 871585006013 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 871585006014 DNA repair protein RadA; Provisional; Region: PRK11823 871585006015 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 871585006016 Walker A motif/ATP binding site; other site 871585006017 ATP binding site [chemical binding]; other site 871585006018 Walker B motif; other site 871585006019 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 871585006020 Tim44 is an essential component of the machinery that mediates the translocation of nuclear-encoded proteins across the mitochondrial inner membrane; Region: Tim44; smart00978 871585006021 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 871585006022 EF-P lysine aminoacylase GenX; Region: genX; TIGR00462 871585006023 motif 1; other site 871585006024 dimer interface [polypeptide binding]; other site 871585006025 active site 871585006026 motif 2; other site 871585006027 motif 3; other site 871585006028 erythronate-4-phosphate dehydrogenase; Validated; Region: PRK00257 871585006029 D-Erythronate-4-Phosphate Dehydrogenase NAD-binding and catalytic domains; Region: ErythrP_dh; cd12158 871585006030 ligand binding site [chemical binding]; other site 871585006031 NAD binding site [chemical binding]; other site 871585006032 catalytic site [active] 871585006033 homodimer interface [polypeptide binding]; other site 871585006034 Protein of unknown function (DUF1232); Region: DUF1232; cl01318 871585006035 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 871585006036 oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701 871585006037 The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767 871585006038 putative molybdopterin cofactor binding site [chemical binding]; other site 871585006039 The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787 871585006040 putative molybdopterin cofactor binding site; other site 871585006041 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 871585006042 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 871585006043 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 871585006044 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 871585006045 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 871585006046 NAD(P) binding site [chemical binding]; other site 871585006047 active site 871585006048 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 871585006049 dimer interface [polypeptide binding]; other site 871585006050 FMN binding site [chemical binding]; other site 871585006051 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 871585006052 Protein export membrane protein; Region: SecD_SecF; cl14618 871585006053 multidrug efflux system protein MdtE; Provisional; Region: PRK09859 871585006054 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 871585006055 HlyD family secretion protein; Region: HlyD_3; pfam13437 871585006056 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 871585006057 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 871585006058 AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246 871585006059 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 871585006060 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 871585006061 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 871585006062 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 871585006063 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 871585006064 Preprotein translocase subunit SecA (ATPase, RNA helicase) [Intracellular trafficking and secretion]; Region: SecA; COG0653 871585006065 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 871585006066 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 871585006067 Transcriptional regulator [Transcription]; Region: LysR; COG0583 871585006068 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 871585006069 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 871585006070 putative effector binding pocket; other site 871585006071 putative dimerization interface [polypeptide binding]; other site 871585006072 SnoaL-like domain; Region: SnoaL_2; pfam12680 871585006073 short chain dehydrogenase; Provisional; Region: PRK06523 871585006074 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 871585006075 NAD(P) binding site [chemical binding]; other site 871585006076 active site 871585006077 transcription elongation factor GreB; Reviewed; Region: greB; PRK01885 871585006078 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 871585006079 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 871585006080 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 871585006081 N-acetyl-D-glucosamine binding site [chemical binding]; other site 871585006082 catalytic residue [active] 871585006083 SCP-2 sterol transfer family; Region: SCP2; pfam02036 871585006084 tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696 871585006085 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 871585006086 Ligand Binding Site [chemical binding]; other site 871585006087 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 871585006088 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 871585006089 N-acetyl-D-glucosamine binding site [chemical binding]; other site 871585006090 catalytic residue [active] 871585006091 heat shock protein HtpX; Provisional; Region: PRK05457 871585006092 Domain of unknown function (DUF4112); Region: DUF4112; pfam13430 871585006093 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 871585006094 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 871585006095 Glycerophosphodiester phosphodiesterase domain of Streptomycin coelicolor (GlpQ1) and similar proteins; Region: GDPD_ScGlpQ1_like; cd08602 871585006096 putative active site [active] 871585006097 catalytic site [active] 871585006098 putative metal binding site [ion binding]; other site 871585006099 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 871585006100 Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818 871585006101 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 871585006102 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 871585006103 ring oligomerisation interface [polypeptide binding]; other site 871585006104 ATP/Mg binding site [chemical binding]; other site 871585006105 stacking interactions; other site 871585006106 hinge regions; other site 871585006107 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 871585006108 oligomerisation interface [polypeptide binding]; other site 871585006109 mobile loop; other site 871585006110 roof hairpin; other site 871585006111 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 871585006112 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 871585006113 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 871585006114 type I secretion C-terminal target domain (VC_A0849 subclass); Region: T1SS_VCA0849; TIGR03661 871585006115 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 871585006116 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 871585006117 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 871585006118 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 871585006119 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 871585006120 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 871585006121 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 871585006122 active site 871585006123 metal binding site [ion binding]; metal-binding site 871585006124 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 871585006125 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 871585006126 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819 871585006127 active site 871585006128 substrate-binding site [chemical binding]; other site 871585006129 metal-binding site [ion binding] 871585006130 GTP binding site [chemical binding]; other site 871585006131 glycerol-3-phosphate dehydrogenase; Reviewed; Region: glpD; PRK12266 871585006132 glycerol kinase; Provisional; Region: glpK; PRK00047 871585006133 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 871585006134 N- and C-terminal domain interface [polypeptide binding]; other site 871585006135 active site 871585006136 MgATP binding site [chemical binding]; other site 871585006137 catalytic site [active] 871585006138 metal binding site [ion binding]; metal-binding site 871585006139 glycerol binding site [chemical binding]; other site 871585006140 homotetramer interface [polypeptide binding]; other site 871585006141 homodimer interface [polypeptide binding]; other site 871585006142 FBP binding site [chemical binding]; other site 871585006143 protein IIAGlc interface [polypeptide binding]; other site 871585006144 alpha-ketoglutarate transporter; Provisional; Region: PRK10406 871585006145 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 871585006146 putative substrate translocation pore; other site 871585006147 Predicted methyltransferase [General function prediction only]; Region: COG3897 871585006148 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 871585006149 S-adenosylmethionine binding site [chemical binding]; other site 871585006150 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14192 871585006151 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 871585006152 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 871585006153 homodimer interface [polypeptide binding]; other site 871585006154 NADP binding site [chemical binding]; other site 871585006155 substrate binding site [chemical binding]; other site 871585006156 PhoD-like phosphatase; Region: PhoD; pfam09423 871585006157 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 871585006158 putative active site [active] 871585006159 putative metal binding site [ion binding]; other site 871585006160 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 871585006161 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 871585006162 dihydropteroate synthase; Region: DHPS; TIGR01496 871585006163 substrate binding pocket [chemical binding]; other site 871585006164 dimer interface [polypeptide binding]; other site 871585006165 inhibitor binding site; inhibition site 871585006166 FtsH Extracellular; Region: FtsH_ext; pfam06480 871585006167 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 871585006168 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 871585006169 Walker A motif; other site 871585006170 ATP binding site [chemical binding]; other site 871585006171 Walker B motif; other site 871585006172 arginine finger; other site 871585006173 Peptidase family M41; Region: Peptidase_M41; pfam01434 871585006174 FtsJ-like methyltransferase; Region: FtsJ; cl17430 871585006175 23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293 871585006176 CRS1 / YhbY (CRM) domain; Region: CRS1_YhbY; pfam01985 871585006177 Domon-like domain of UDP-N-acetylenolpyruvoylglucosamine reductase; Region: DOMON_murB_like; cd09627 871585006178 putative heme binding site [chemical binding]; other site 871585006179 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 871585006180 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 871585006181 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 871585006182 catalytic site [active] 871585006183 subunit interface [polypeptide binding]; other site 871585006184 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 871585006185 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 871585006186 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 871585006187 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 871585006188 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 871585006189 ATP-grasp domain; Region: ATP-grasp_4; cl17255 871585006190 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 871585006191 IMP binding site; other site 871585006192 dimer interface [polypeptide binding]; other site 871585006193 interdomain contacts; other site 871585006194 partial ornithine binding site; other site 871585006195 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 871585006196 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 871585006197 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 871585006198 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 871585006199 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 871585006200 YjgH belongs to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgH_like; cd02198 871585006201 homotrimer interaction site [polypeptide binding]; other site 871585006202 putative active site [active] 871585006203 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 871585006204 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 871585006205 trimer interface [polypeptide binding]; other site 871585006206 active site 871585006207 substrate binding site [chemical binding]; other site 871585006208 CoA binding site [chemical binding]; other site 871585006209 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 871585006210 Ligand Binding Site [chemical binding]; other site 871585006211 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 871585006212 DNA binding site [nucleotide binding] 871585006213 active site 871585006214 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 871585006215 active site 871585006216 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 871585006217 putative active site [active] 871585006218 putative metal binding site [ion binding]; other site 871585006219 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 871585006220 type 2 lantibiotic biosynthesis protein LanM; Region: lanti_2_LanM; TIGR03897 871585006221 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 871585006222 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 871585006223 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 871585006224 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 871585006225 type I secretion C-terminal target domain (VC_A0849 subclass); Region: T1SS_VCA0849; TIGR03661 871585006226 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 871585006227 Predicted metalloprotease [General function prediction only]; Region: COG2321 871585006228 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 871585006229 Protein of unknown function (DUF808); Region: DUF808; pfam05661 871585006230 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 871585006231 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 871585006232 active site 871585006233 HIGH motif; other site 871585006234 dimer interface [polypeptide binding]; other site 871585006235 KMSKS motif; other site 871585006236 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 871585006237 CoA binding domain; Region: CoA_binding; smart00881 871585006238 CoA-ligase; Region: Ligase_CoA; pfam00549 871585006239 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 871585006240 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 871585006241 CoA-ligase; Region: Ligase_CoA; pfam00549 871585006242 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06467 871585006243 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 871585006244 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 871585006245 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 871585006246 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 871585006247 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 871585006248 E3 interaction surface; other site 871585006249 lipoyl attachment site [posttranslational modification]; other site 871585006250 e3 binding domain; Region: E3_binding; pfam02817 871585006251 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 871585006252 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 871585006253 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 871585006254 TPP-binding site [chemical binding]; other site 871585006255 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 871585006256 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 871585006257 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 871585006258 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07057 871585006259 L-aspartate oxidase; Provisional; Region: PRK06175 871585006260 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 871585006261 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. E. coli SQR, a member of this subfamily, reduces the...; Region: SQR_TypeC_SdhD; cd03494 871585006262 SdhC subunit interface [polypeptide binding]; other site 871585006263 proximal heme binding site [chemical binding]; other site 871585006264 cardiolipin binding site; other site 871585006265 Iron-sulfur protein interface; other site 871585006266 proximal quinone binding site [chemical binding]; other site 871585006267 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499 871585006268 proximal quinone binding site [chemical binding]; other site 871585006269 SdhD (CybS) interface [polypeptide binding]; other site 871585006270 proximal heme binding site [chemical binding]; other site 871585006271 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 871585006272 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 871585006273 dimer interface [polypeptide binding]; other site 871585006274 active site 871585006275 citrylCoA binding site [chemical binding]; other site 871585006276 NADH binding [chemical binding]; other site 871585006277 cationic pore residues; other site 871585006278 oxalacetate/citrate binding site [chemical binding]; other site 871585006279 coenzyme A binding site [chemical binding]; other site 871585006280 catalytic triad [active] 871585006281 Protein of unknown function (DUF1289); Region: DUF1289; pfam06945 871585006282 Predicted sulfurtransferase [General function prediction only]; Region: COG1054 871585006283 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 871585006284 active site residue [active] 871585006285 Uncharacterized protein family (UPF0149); Region: UPF0149; pfam03695 871585006286 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 871585006287 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 871585006288 Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546 871585006289 RNA polymerase sigma factor RpoD, C-terminal domain; Region: RpoD_Cterm; TIGR02393 871585006290 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 871585006291 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 871585006292 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 871585006293 DNA binding residues [nucleotide binding] 871585006294 Protein of unknown function (DUF493); Region: DUF493; pfam04359 871585006295 lipoate-protein ligase B; Provisional; Region: PRK14342 871585006296 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 871585006297 Iron-containing alcohol dehydrogenases-like; Region: Fe-ADH5; cd08189 871585006298 putative active site [active] 871585006299 metal binding site [ion binding]; metal-binding site 871585006300 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 871585006301 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 871585006302 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 871585006303 Predicted transcriptional regulators [Transcription]; Region: COG1733 871585006304 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 871585006305 dimerization interface [polypeptide binding]; other site 871585006306 putative DNA binding site [nucleotide binding]; other site 871585006307 putative Zn2+ binding site [ion binding]; other site 871585006308 Cupin-like domain; Region: Cupin_8; pfam13621 871585006309 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 871585006310 siroheme synthase; Provisional; Region: cysG; PRK10637 871585006311 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 871585006312 Sirohaem synthase dimerisation region; Region: CysG_dimeriser; pfam10414 871585006313 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 871585006314 active site 871585006315 SAM binding site [chemical binding]; other site 871585006316 homodimer interface [polypeptide binding]; other site 871585006317 seryl-tRNA synthetase; Provisional; Region: PRK05431 871585006318 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 871585006319 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 871585006320 dimer interface [polypeptide binding]; other site 871585006321 active site 871585006322 motif 1; other site 871585006323 motif 2; other site 871585006324 motif 3; other site 871585006325 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 871585006326 lipoprotein chaperone; Reviewed; Region: lolA; PRK00031 871585006327 Outer membrane lipoprotein carrier protein LolA; Region: LolA; pfam03548 871585006328 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 871585006329 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 871585006330 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 871585006331 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 871585006332 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 871585006333 substrate binding pocket [chemical binding]; other site 871585006334 chain length determination region; other site 871585006335 substrate-Mg2+ binding site; other site 871585006336 catalytic residues [active] 871585006337 aspartate-rich region 1; other site 871585006338 active site lid residues [active] 871585006339 aspartate-rich region 2; other site 871585006340 Site-specific recombinase; Region: SpecificRecomb; pfam10136 871585006341 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 871585006342 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 871585006343 active site 871585006344 multidrug efflux system transporter AcrA; Provisional; Region: PRK15030 871585006345 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 871585006346 HlyD family secretion protein; Region: HlyD_3; pfam13437 871585006347 potential frameshift: common BLAST hit: gi|215482463|ref|YP_002324649.1| AcrB protein 871585006348 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 871585006349 Protein export membrane protein; Region: SecD_SecF; cl14618 871585006350 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 871585006351 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 871585006352 Putative heavy-metal-binding; Region: YbjQ_1; cl00426 871585006353 Uncharacterized conserved protein [Function unknown]; Region: COG0393 871585006354 SnoaL-like domain; Region: SnoaL_4; pfam13577 871585006355 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 871585006356 short chain dehydrogenase; Provisional; Region: PRK06181 871585006357 NAD(P) binding site [chemical binding]; other site 871585006358 active site 871585006359 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 871585006360 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 871585006361 HIGH motif; other site 871585006362 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 871585006363 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 871585006364 active site 871585006365 KMSKS motif; other site 871585006366 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 871585006367 tRNA binding surface [nucleotide binding]; other site 871585006368 anticodon binding site; other site 871585006369 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 871585006370 Predicted ATP-binding protein involved in virulence [General function prediction only]; Region: COG3950 871585006371 Predicted permeases [General function prediction only]; Region: COG0679 871585006372 Transcriptional regulator [Transcription]; Region: LysR; COG0583 871585006373 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 871585006374 putative DNA binding site [nucleotide binding]; other site 871585006375 putative Zn2+ binding site [ion binding]; other site 871585006376 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 871585006377 dimerization interface [polypeptide binding]; other site 871585006378 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 871585006379 PAP2_like_6 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which mainly contains bacterial proteins, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_6; cd03396 871585006380 active site 871585006381 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 871585006382 dimer interface [polypeptide binding]; other site 871585006383 phosphorylation site [posttranslational modification] 871585006384 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 871585006385 ATP binding site [chemical binding]; other site 871585006386 Mg2+ binding site [ion binding]; other site 871585006387 G-X-G motif; other site 871585006388 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 871585006389 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 871585006390 active site 871585006391 phosphorylation site [posttranslational modification] 871585006392 intermolecular recognition site; other site 871585006393 dimerization interface [polypeptide binding]; other site 871585006394 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 871585006395 DNA binding site [nucleotide binding] 871585006396 putative metal dependent hydrolase; Provisional; Region: PRK11598 871585006397 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 871585006398 Sulfatase; Region: Sulfatase; pfam00884 871585006399 muropeptide transporter; Validated; Region: ampG; cl17669 871585006400 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 871585006401 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown ABO13168; Region: LPLAT_ABO13168-like; cd07988 871585006402 putative acyl-acceptor binding pocket; other site 871585006403 hypothetical protein; Provisional; Region: PRK10279 871585006404 Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205 871585006405 nucleophile elbow; other site 871585006406 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 871585006407 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 871585006408 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 871585006409 Protein of unknown function (DUF419); Region: DUF419; cl15265 871585006410 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 871585006411 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 871585006412 substrate binding pocket [chemical binding]; other site 871585006413 chain length determination region; other site 871585006414 substrate-Mg2+ binding site; other site 871585006415 catalytic residues [active] 871585006416 aspartate-rich region 1; other site 871585006417 active site lid residues [active] 871585006418 aspartate-rich region 2; other site 871585006419 probable AcnD-accessory protein PrpF; Region: prpF; TIGR02334 871585006420 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 871585006421 Protein of unknown function (DUF2805); Region: DUF2805; pfam10985 871585006422 chaperone protein HchA; Provisional; Region: PRK04155 871585006423 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 871585006424 conserved cys residue [active] 871585006425 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 871585006426 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 871585006427 NAD(P) binding site [chemical binding]; other site 871585006428 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 871585006429 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 871585006430 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 871585006431 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 871585006432 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 871585006433 PaaX-like protein C-terminal domain; Region: PaaX_C; pfam08223 871585006434 This CD includes the dihydrorhizobitoxine fatty acid desaturase (RtxC) characterized in Bradyrhizobium japonicum USDA110, and other related proteins. Dihydrorhizobitoxine desaturase is reported to be involved in the final step of rhizobitoxine...; Region: Rhizobitoxine-FADS-like; cd03510 871585006435 putative di-iron ligands [ion binding]; other site 871585006436 This CD includes the dihydrorhizobitoxine fatty acid desaturase (RtxC) characterized in Bradyrhizobium japonicum USDA110, and other related proteins. Dihydrorhizobitoxine desaturase is reported to be involved in the final step of rhizobitoxine...; Region: Rhizobitoxine-FADS-like; cd03510 871585006437 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 871585006438 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 871585006439 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 871585006440 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 871585006441 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 871585006442 Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; cl17479 871585006443 phosphoserine phosphatase; Provisional; Region: thrH; PRK13582 871585006444 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 871585006445 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 871585006446 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 871585006447 Active Sites [active] 871585006448 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 871585006449 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 871585006450 ribonuclease G; Provisional; Region: PRK11712 871585006451 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 871585006452 homodimer interface [polypeptide binding]; other site 871585006453 oligonucleotide binding site [chemical binding]; other site 871585006454 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 871585006455 active site 871585006456 dimer interface [polypeptide binding]; other site 871585006457 rod shape-determining protein MreC; Provisional; Region: PRK13922 871585006458 rod shape-determining protein MreC; Region: MreC; pfam04085 871585006459 potential frameshift: common BLAST hit: gi|229577090|ref|YP_001085795.2| rod shape-determining protein MreB 871585006460 MreB and similar proteins; Region: MreB_like; cd10225 871585006461 RodZ interaction site [polypeptide binding]; other site 871585006462 putative protofilament interaction site [polypeptide binding]; other site 871585006463 nucleotide binding site [chemical binding]; other site 871585006464 Mg binding site [ion binding]; other site 871585006465 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 871585006466 nucleotide binding site [chemical binding]; other site 871585006467 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 871585006468 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 871585006469 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 871585006470 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 871585006471 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 871585006472 GatB domain; Region: GatB_Yqey; smart00845 871585006473 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_1; cd03169 871585006474 intracellular protease, PfpI family; Region: PfpI; TIGR01382 871585006475 conserved cys residue [active] 871585006476 Protein of unknown function (DUF1176); Region: DUF1176; pfam06674 871585006477 microcin B17 transporter; Reviewed; Region: PRK11098 871585006478 threonine dehydratase; Provisional; Region: PRK07334 871585006479 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 871585006480 tetramer interface [polypeptide binding]; other site 871585006481 pyridoxal 5'-phosphate binding site [chemical binding]; other site 871585006482 catalytic residue [active] 871585006483 C-terminal ACT domain of biodegradative (catabolic) threonine dehydratase II (ThrD-II) and other related ACT domains; Region: ACT_ThrD-II-like; cd04886 871585006484 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 871585006485 Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205 871585006486 active site 871585006487 nucleophile elbow; other site 871585006488 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 871585006489 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 871585006490 Nitroreductase family. Members of this family utilize FMN as a cofactor and catalyze reduction of a variety of nitroaromatic compounds, including nitrofurans, nitrobenzens, nitrophenol, nitrobenzoate and quinones by using either NADH or NADPH as a source...; Region: Nitroreductase; cd02136 871585006491 putative FMN binding site [chemical binding]; other site 871585006492 bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102 871585006493 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 871585006494 putative substrate translocation pore; other site 871585006495 TIGR01666 family membrane protein; Region: YCCS 871585006496 FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805 871585006497 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 871585006498 YcxB-like protein; Region: YcxB; pfam14317 871585006499 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 871585006500 PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172 871585006501 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 871585006502 Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; Region: CysJ; COG0369 871585006503 Flavodoxin; Region: Flavodoxin_1; pfam00258 871585006504 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR_like1; cd06200 871585006505 FAD binding pocket [chemical binding]; other site 871585006506 FAD binding motif [chemical binding]; other site 871585006507 catalytic residues [active] 871585006508 NAD binding pocket [chemical binding]; other site 871585006509 phosphate binding motif [ion binding]; other site 871585006510 beta-alpha-beta structure motif; other site 871585006511 Uncharacterized conserved protein [Function unknown]; Region: COG1434 871585006512 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 871585006513 putative active site [active] 871585006514 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 871585006515 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 871585006516 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2832 871585006517 Domain of unknown function (DUF1853); Region: DUF1853; cl01545 871585006518 entericidin A; Provisional; Region: PRK09810 871585006519 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009 871585006520 M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891 871585006521 metal binding site [ion binding]; metal-binding site 871585006522 dimer interface [polypeptide binding]; other site 871585006523 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 871585006524 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 871585006525 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 871585006526 putative binding surface; other site 871585006527 active site 871585006528 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 871585006529 putative binding surface; other site 871585006530 active site 871585006531 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 871585006532 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 871585006533 putative binding surface; other site 871585006534 active site 871585006535 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 871585006536 putative binding surface; other site 871585006537 active site 871585006538 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 871585006539 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 871585006540 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 871585006541 ATP binding site [chemical binding]; other site 871585006542 Mg2+ binding site [ion binding]; other site 871585006543 G-X-G motif; other site 871585006544 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 871585006545 Response regulator receiver domain; Region: Response_reg; pfam00072 871585006546 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 871585006547 active site 871585006548 phosphorylation site [posttranslational modification] 871585006549 intermolecular recognition site; other site 871585006550 dimerization interface [polypeptide binding]; other site 871585006551 Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675 871585006552 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 871585006553 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 871585006554 dimer interface [polypeptide binding]; other site 871585006555 putative CheW interface [polypeptide binding]; other site 871585006556 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 871585006557 Response regulator receiver domain; Region: Response_reg; pfam00072 871585006558 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 871585006559 active site 871585006560 phosphorylation site [posttranslational modification] 871585006561 intermolecular recognition site; other site 871585006562 dimerization interface [polypeptide binding]; other site 871585006563 Response regulator receiver domain; Region: Response_reg; pfam00072 871585006564 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 871585006565 active site 871585006566 phosphorylation site [posttranslational modification] 871585006567 intermolecular recognition site; other site 871585006568 dimerization interface [polypeptide binding]; other site 871585006569 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 871585006570 HlyD family secretion protein; Region: HlyD_3; pfam13437 871585006571 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 871585006572 prolyl-tRNA synthetase; Provisional; Region: PRK09194 871585006573 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 871585006574 dimer interface [polypeptide binding]; other site 871585006575 motif 1; other site 871585006576 active site 871585006577 motif 2; other site 871585006578 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 871585006579 putative deacylase active site [active] 871585006580 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 871585006581 active site 871585006582 motif 3; other site 871585006583 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 871585006584 anticodon binding site; other site 871585006585 Domain of unknown function (DUF1508); Region: DUF1508; cl01356 871585006586 Domain of unknown function (DUF1508); Region: DUF1508; pfam07411 871585006587 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 871585006588 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 871585006589 PhnA protein; Region: PhnA; pfam03831 871585006590 Uncharacterized conserved protein [Function unknown]; Region: COG3189 871585006591 pyrimidine utilization protein D; Region: RutD; TIGR03611 871585006592 Nitroreductase-like family 5. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_5; cd02148 871585006593 putative FMN binding site [chemical binding]; other site 871585006594 pyrimidine utilization protein A; Region: RutA; TIGR03612 871585006595 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 871585006596 active site 871585006597 dimer interface [polypeptide binding]; other site 871585006598 non-prolyl cis peptide bond; other site 871585006599 insertion regions; other site 871585006600 Isochorismatase family; Region: Isochorismatase; pfam00857 871585006601 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 871585006602 catalytic triad [active] 871585006603 conserved cis-peptide bond; other site 871585006604 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 871585006605 homotrimer interaction site [polypeptide binding]; other site 871585006606 putative active site [active] 871585006607 pyrimidine utilization flavin reductase protein F; Region: RutF; TIGR03615 871585006608 pyrimidine utilization transport protein G; Region: RutG; TIGR03616 871585006609 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 871585006610 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 871585006611 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_2; cd08895 871585006612 putative hydrophobic ligand binding site [chemical binding]; other site 871585006613 Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354 871585006614 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 871585006615 protein disulfide isomerase II DsbC; Provisional; Region: PRK10877 871585006616 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020 871585006617 dimerization domain [polypeptide binding]; other site 871585006618 dimer interface [polypeptide binding]; other site 871585006619 catalytic residues [active] 871585006620 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 871585006621 Sel1-like repeats; Region: SEL1; smart00671 871585006622 Predicted permeases [General function prediction only]; Region: COG0679 871585006623 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 871585006624 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 871585006625 active site 871585006626 FMN binding site [chemical binding]; other site 871585006627 substrate binding site [chemical binding]; other site 871585006628 homotetramer interface [polypeptide binding]; other site 871585006629 catalytic residue [active] 871585006630 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 871585006631 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 871585006632 N-terminal plug; other site 871585006633 ligand-binding site [chemical binding]; other site 871585006634 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 871585006635 active site 871585006636 DNA binding site [nucleotide binding] 871585006637 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 871585006638 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 871585006639 DNA binding site [nucleotide binding] 871585006640 catalytic residue [active] 871585006641 H2TH interface [polypeptide binding]; other site 871585006642 putative catalytic residues [active] 871585006643 turnover-facilitating residue; other site 871585006644 intercalation triad [nucleotide binding]; other site 871585006645 8OG recognition residue [nucleotide binding]; other site 871585006646 putative reading head residues; other site 871585006647 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 871585006648 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 871585006649 PPIC-type PPIASE domain; Region: Rotamase_2; cl08278 871585006650 The Maltoporin-like channels (LamB porin) form a trimeric structure which facilitate the diffusion of maltodextrins and other sugars across the outer membrane of Gram-negative bacteria. The membrane channel is formed by an 18-strand antiparallel...; Region: Maltoporin-like; cd01346 871585006651 trimer interface; other site 871585006652 sugar binding site [chemical binding]; other site 871585006653 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 871585006654 putative active site pocket [active] 871585006655 dimerization interface [polypeptide binding]; other site 871585006656 putative catalytic residue [active] 871585006657 large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13952 871585006658 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 871585006659 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 871585006660 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 871585006661 G1 box; other site 871585006662 putative GEF interaction site [polypeptide binding]; other site 871585006663 GTP/Mg2+ binding site [chemical binding]; other site 871585006664 Switch I region; other site 871585006665 G2 box; other site 871585006666 G3 box; other site 871585006667 Switch II region; other site 871585006668 G4 box; other site 871585006669 G5 box; other site 871585006670 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 871585006671 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 871585006672 Xanthine/uracil permeases [Nucleotide transport and metabolism]; Region: UraA; COG2233 871585006673 16S ribosomal RNA m2G1207 methyltransferase; Provisional; Region: rsmC; PRK09489 871585006674 Methyltransferase small domain N-terminal; Region: MTS_N; pfam08468 871585006675 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 871585006676 S-adenosylmethionine binding site [chemical binding]; other site 871585006677 lysine transporter; Provisional; Region: PRK10836 871585006678 Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139 871585006679 hypothetical protein; Reviewed; Region: PRK09588 871585006680 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 871585006681 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 871585006682 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 871585006683 ligand binding site [chemical binding]; other site 871585006684 Type II transport protein GspH; Region: GspH; pfam12019 871585006685 acetyl-CoA acetyltransferase; Provisional; Region: PRK06954 871585006686 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 871585006687 dimer interface [polypeptide binding]; other site 871585006688 active site 871585006689 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 871585006690 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 871585006691 dimer interface [polypeptide binding]; other site 871585006692 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 871585006693 Bacterial protein of unknown function (DUF934); Region: DUF934; pfam06073 871585006694 Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155 871585006695 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 871585006696 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 871585006697 membrane-bound PQQ-dependent dehydrogenase, glucose/quinate/shikimate family; Region: PQQ_membr_DH; TIGR03074 871585006698 Membrane-bound PQQ-dependent glucose dehydrogenase; Region: PQQ_mGDH; cd10280 871585006699 Trp docking motif [polypeptide binding]; other site 871585006700 putative active site [active] 871585006701 Carbohydrate-selective porin, OprB family; Region: OprB; cl17816 871585006702 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 871585006703 CoA-transferase family III; Region: CoA_transf_3; pfam02515 871585006704 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 871585006705 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 871585006706 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 871585006707 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 871585006708 acetyl-CoA acetyltransferase; Validated; Region: PRK08242 871585006709 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 871585006710 dimer interface [polypeptide binding]; other site 871585006711 active site 871585006712 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 871585006713 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 871585006714 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 871585006715 trimer interface [polypeptide binding]; other site 871585006716 oxyanion hole (OAH) forming residues; other site 871585006717 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK09260 871585006718 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 871585006719 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 871585006720 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667 871585006721 Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208 871585006722 active site 871585006723 nucleophile elbow; other site 871585006724 Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; pfam13444 871585006725 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 871585006726 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 871585006727 Methyltransferase domain; Region: Methyltransf_31; pfam13847 871585006728 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 871585006729 S-adenosylmethionine binding site [chemical binding]; other site 871585006730 Haemolysin-III related; Region: HlyIII; cl03831 871585006731 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 871585006732 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 871585006733 metabolite-proton symporter; Region: 2A0106; TIGR00883 871585006734 putative substrate translocation pore; other site 871585006735 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 871585006736 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 871585006737 SEC-C motif; Region: SEC-C; pfam02810 871585006738 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 871585006739 Peroxiredoxin (PRX) family, 1-cys PRX subfamily; composed of PRXs containing only one conserved cysteine, which serves as the peroxidatic cysteine. They are homodimeric thiol-specific antioxidant (TSA) proteins that confer a protective role in cells by...; Region: PRX_1cys; cd03016 871585006740 dimer interface [polypeptide binding]; other site 871585006741 decamer (pentamer of dimers) interface [polypeptide binding]; other site 871585006742 catalytic triad [active] 871585006743 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 871585006744 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 871585006745 active site 871585006746 catalytic residues [active] 871585006747 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 871585006748 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 871585006749 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 871585006750 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 871585006751 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 871585006752 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 871585006753 substrate binding site [chemical binding]; other site 871585006754 active site 871585006755 catalytic residues [active] 871585006756 heterodimer interface [polypeptide binding]; other site 871585006757 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 871585006758 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 871585006759 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 871585006760 Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118 871585006761 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687 871585006762 Protein of unknown function (DUF2804); Region: DUF2804; pfam10974 871585006763 Domain of Unknown Function (DUF1543); Region: DUF1543; pfam07566 871585006764 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 871585006765 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 871585006766 pyridoxal 5'-phosphate binding site [chemical binding]; other site 871585006767 catalytic residue [active] 871585006768 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 871585006769 active site 871585006770 Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206 871585006771 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 871585006772 N-terminal plug; other site 871585006773 ligand-binding site [chemical binding]; other site 871585006774 Cobalamin adenosyltransferase; Region: Cob_adeno_trans; pfam01923 871585006775 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 871585006776 Glycerophosphodiester phosphodiesterase domain as found in prokaryota and eukaryota, and similar proteins; Region: GDPD; cd08556 871585006777 active site 871585006778 catalytic site [active] 871585006779 metal binding site [ion binding]; metal-binding site 871585006780 META domain; Region: META; pfam03724 871585006781 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 871585006782 Fatty acid desaturase; Region: FA_desaturase; pfam00487 871585006783 Di-iron ligands [ion binding]; other site 871585006784 Uncharacterized conserved protein [Function unknown]; Region: COG0397 871585006785 hypothetical protein; Validated; Region: PRK00029 871585006786 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 871585006787 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 871585006788 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 871585006789 active site 871585006790 phosphorylation site [posttranslational modification] 871585006791 intermolecular recognition site; other site 871585006792 dimerization interface [polypeptide binding]; other site 871585006793 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 871585006794 DNA binding site [nucleotide binding] 871585006795 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 871585006796 dimerization interface [polypeptide binding]; other site 871585006797 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 871585006798 dimer interface [polypeptide binding]; other site 871585006799 phosphorylation site [posttranslational modification] 871585006800 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 871585006801 ATP binding site [chemical binding]; other site 871585006802 Mg2+ binding site [ion binding]; other site 871585006803 G-X-G motif; other site 871585006804 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 871585006805 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 871585006806 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 871585006807 active site 871585006808 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 871585006809 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 871585006810 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 871585006811 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 871585006812 active site 871585006813 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 871585006814 LysR family transcriptional regulator; Provisional; Region: PRK14997 871585006815 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 871585006816 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 871585006817 putative effector binding pocket; other site 871585006818 dimerization interface [polypeptide binding]; other site 871585006819 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 871585006820 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 871585006821 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 871585006822 N-terminal domain interface [polypeptide binding]; other site 871585006823 dimer interface [polypeptide binding]; other site 871585006824 substrate binding pocket (H-site) [chemical binding]; other site 871585006825 Predicted membrane protein [Function unknown]; Region: COG3223 871585006826 Domain of unknown function (DUF3315); Region: DUF3315; pfam11776 871585006827 Putative catalytic domain, repeat 1, of uncharacterized phospholipase D-like proteins; Region: PLDc_unchar2_1; cd09129 871585006828 putative active site [active] 871585006829 putative catalytic site [active] 871585006830 Putative catalytic domain, repeat 2, of uncharacterized phospholipase D-like proteins; Region: PLDc_unchar2_2; cd09130 871585006831 PLD-like domain; Region: PLDc_2; pfam13091 871585006832 putative active site [active] 871585006833 putative catalytic site [active] 871585006834 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 871585006835 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 871585006836 N-terminal plug; other site 871585006837 ligand-binding site [chemical binding]; other site 871585006838 Domain of unknown function (DUF4184); Region: DUF4184; pfam13803 871585006839 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 871585006840 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 871585006841 dimer interface [polypeptide binding]; other site 871585006842 anticodon binding site; other site 871585006843 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 871585006844 homodimer interface [polypeptide binding]; other site 871585006845 motif 1; other site 871585006846 active site 871585006847 motif 2; other site 871585006848 GAD domain; Region: GAD; pfam02938 871585006849 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 871585006850 active site 871585006851 motif 3; other site 871585006852 Protein of unknown function (DUF3184); Region: DUF3184; pfam11380 871585006853 Glycosyltransferase family 25 [lipooligosaccharide (LOS) biosynthesis protein] is a family of glycosyltransferases involved in LOS biosynthesis. The members include the beta(1,4) galactosyltransferases: Lgt2 of Moraxella catarrhalis, LgtB and LgtE of...; Region: Glyco_transf_25; cd06532 871585006854 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 871585006855 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 871585006856 putative ADP-binding pocket [chemical binding]; other site 871585006857 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 871585006858 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 871585006859 putative metal binding site; other site 871585006860 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 871585006861 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 871585006862 putative active site [active] 871585006863 putative metal binding site [ion binding]; other site 871585006864 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 871585006865 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 871585006866 phosphorylation site [posttranslational modification] 871585006867 Predicted nucleoside-diphosphate-sugar epimerase [Cell envelope biogenesis, outer membrane]; Region: COG3660 871585006868 Mitochondrial fission ELM1; Region: Mito_fiss_Elm1; pfam06258 871585006869 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 871585006870 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 871585006871 homodimer interface [polypeptide binding]; other site 871585006872 substrate-cofactor binding pocket; other site 871585006873 catalytic residue [active] 871585006874 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Reviewed; Region: PRK11072 871585006875 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 871585006876 metal binding triad; other site 871585006877 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 871585006878 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 871585006879 metal binding triad; other site 871585006880 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 871585006881 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 871585006882 dimer interface [polypeptide binding]; other site 871585006883 phosphorylation site [posttranslational modification] 871585006884 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 871585006885 ATP binding site [chemical binding]; other site 871585006886 Mg2+ binding site [ion binding]; other site 871585006887 G-X-G motif; other site 871585006888 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 871585006889 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 871585006890 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 871585006891 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 871585006892 preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585 871585006893 SecD export protein N-terminal TM region; Region: SecD-TM1; pfam13721 871585006894 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 871585006895 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 871585006896 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 871585006897 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 871585006898 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 871585006899 Protein export membrane protein; Region: SecD_SecF; pfam02355 871585006900 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 871585006901 Flavoprotein; Region: Flavoprotein; pfam02441 871585006902 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 871585006903 hypothetical protein; Reviewed; Region: PRK00024 871585006904 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 871585006905 MPN+ (JAMM) motif; other site 871585006906 Zinc-binding site [ion binding]; other site 871585006907 Bestrophin, RFP-TM, chloride channel; Region: Bestrophin; pfam01062 871585006908 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 871585006909 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 871585006910 active site 871585006911 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 871585006912 Intracellular septation protein A; Region: IspA; pfam04279 871585006913 YciI-like protein; Reviewed; Region: PRK11370 871585006914 bifunctional tRNA (mnm(5)s(2)U34)-methyltransferase/FAD-dependent cmnm(5)s(2)U34 oxidoreductase; Reviewed; Region: mnmC; PRK01747 871585006915 Uncharacterized conserved protein [Function unknown]; Region: COG4121 871585006916 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 871585006917 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 871585006918 active site residue [active] 871585006919 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 871585006920 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 871585006921 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 871585006922 CoenzymeA binding site [chemical binding]; other site 871585006923 subunit interaction site [polypeptide binding]; other site 871585006924 PHB binding site; other site 871585006925 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 871585006926 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 871585006927 thioredoxin 2; Provisional; Region: PRK10996 871585006928 zinc-ribbon domain; Region: zinc_ribbon_5; cl11777 871585006929 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 871585006930 catalytic residues [active] 871585006931 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 871585006932 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 871585006933 Putative phosphatase (DUF442); Region: DUF442; cl17385 871585006934 dihydrolipoamide dehydrogenase; Validated; Region: PRK06292 871585006935 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 871585006936 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 871585006937 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 871585006938 substrate binding site [chemical binding]; other site 871585006939 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 871585006940 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 871585006941 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 871585006942 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 871585006943 transcriptional regulator; Provisional; Region: PRK10632 871585006944 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 871585006945 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 871585006946 putative effector binding pocket; other site 871585006947 dimerization interface [polypeptide binding]; other site 871585006948 GrpE; Region: GrpE; pfam01025 871585006949 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 871585006950 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 871585006951 dimer interface [polypeptide binding]; other site 871585006952 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 871585006953 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 871585006954 nucleotide binding site [chemical binding]; other site 871585006955 potential frameshift: common BLAST hit: gi|299772102|ref|YP_003734128.1| Matrixin family protein 871585006956 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 871585006957 active site 871585006958 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 871585006959 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 871585006960 active site 871585006961 active site 871585006962 Transglycosylase SLT domain; Region: SLT_2; pfam13406 871585006963 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 871585006964 N-acetyl-D-glucosamine binding site [chemical binding]; other site 871585006965 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 871585006966 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 871585006967 ATP-grasp domain; Region: ATP-grasp; pfam02222 871585006968 AIR carboxylase; Region: AIRC; pfam00731 871585006969 Protein of unknown function, DUF486; Region: DUF486; cl01236 871585006970 UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase; Region: mpl; TIGR01081 871585006971 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 871585006972 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 871585006973 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 871585006974 Bacterial low temperature requirement A protein (LtrA); Region: LtrA; cl01754 871585006975 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 871585006976 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 871585006977 active site 871585006978 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 871585006979 Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754 871585006980 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 871585006981 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 871585006982 [2Fe-2S] cluster binding site [ion binding]; other site 871585006983 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 871585006984 hydrophobic ligand binding site; other site 871585006985 guanine deaminase; Provisional; Region: PRK09228 871585006986 Guanine deaminase (GDEase). Guanine deaminase is an aminohydrolase responsible for the conversion of guanine to xanthine and ammonia, the first step to utilize guanine as a nitrogen source. This reaction also removes the guanine base from the pool and...; Region: GDEase; cd01303 871585006987 active site 871585006988 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 871585006989 active site 871585006990 Predicted membrane protein [Function unknown]; Region: COG2261 871585006991 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 871585006992 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020 871585006993 dimerization domain [polypeptide binding]; other site 871585006994 dimer interface [polypeptide binding]; other site 871585006995 catalytic residues [active] 871585006996 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 871585006997 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 871585006998 Transcriptional regulators RcnR and FrmR, and related domains; this domain family was previously known as part of DUF156; Region: RcnR-FrmR-like_DUF156; cd10153 871585006999 putative metal binding site [ion binding]; other site 871585007000 putative homodimer interface [polypeptide binding]; other site 871585007001 putative homotetramer interface [polypeptide binding]; other site 871585007002 putative homodimer-homodimer interface [polypeptide binding]; other site 871585007003 putative allosteric switch controlling residues; other site 871585007004 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 871585007005 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 871585007006 trmE is a tRNA modification GTPase; Region: trmE; cd04164 871585007007 G1 box; other site 871585007008 GTP/Mg2+ binding site [chemical binding]; other site 871585007009 Switch I region; other site 871585007010 G2 box; other site 871585007011 Switch II region; other site 871585007012 G3 box; other site 871585007013 G4 box; other site 871585007014 G5 box; other site 871585007015 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 871585007016 membrane protein insertase; Provisional; Region: PRK01318 871585007017 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 871585007018 Ribonuclease P; Region: Ribonuclease_P; pfam00825 871585007019 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 871585007020 DnaA N-terminal domain; Region: DnaA_N; pfam11638 871585007021 chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362 871585007022 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 871585007023 Walker A motif; other site 871585007024 ATP binding site [chemical binding]; other site 871585007025 Walker B motif; other site 871585007026 arginine finger; other site 871585007027 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 871585007028 DnaA box-binding interface [nucleotide binding]; other site 871585007029 potential frameshift: common BLAST hit: gi|299768252|ref|YP_003730278.1| DNA polymerase III, beta subunit 871585007030 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cl17512 871585007031 putative DNA binding surface [nucleotide binding]; other site 871585007032 dimer interface [polypeptide binding]; other site 871585007033 DNA polymerase III subunit beta; Validated; Region: PRK05643 871585007034 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 871585007035 beta-clamp/clamp loader binding surface; other site 871585007036 beta-clamp/translesion DNA polymerase binding surface; other site 871585007037 recombination protein F; Reviewed; Region: recF; PRK00064 871585007038 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 871585007039 Walker A/P-loop; other site 871585007040 ATP binding site [chemical binding]; other site 871585007041 Q-loop/lid; other site 871585007042 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 871585007043 ABC transporter signature motif; other site 871585007044 Walker B; other site 871585007045 D-loop; other site 871585007046 H-loop/switch region; other site 871585007047 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 871585007048 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 871585007049 Mg2+ binding site [ion binding]; other site 871585007050 G-X-G motif; other site 871585007051 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 871585007052 anchoring element; other site 871585007053 dimer interface [polypeptide binding]; other site 871585007054 ATP binding site [chemical binding]; other site 871585007055 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 871585007056 active site 871585007057 putative metal-binding site [ion binding]; other site 871585007058 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 871585007059 Cytochrome b562; Region: Cytochrom_B562; pfam07361 871585007060 Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823 871585007061 putative ABC transporter ATP-binding protein; Provisional; Region: PRK10636 871585007062 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 871585007063 ABC transporter; Region: ABC_tran_2; pfam12848 871585007064 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 871585007065 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 871585007066 potential frameshift: common BLAST hit: gi|213155376|ref|YP_002317421.1| RND type efflux pump 871585007067 iron-sulfur cluster insertion protein ErpA; Provisional; Region: PRK13623 871585007068 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 871585007069 anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585 871585007070 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 871585007071 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 871585007072 active site 871585007073 HIGH motif; other site 871585007074 dimer interface [polypeptide binding]; other site 871585007075 KMSKS motif; other site 871585007076 Domain of unknown function (DUF4154); Region: DUF4154; pfam13689 871585007077 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 871585007078 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 871585007079 metal binding site [ion binding]; metal-binding site 871585007080 active site 871585007081 I-site; other site 871585007082 putative outer membrane lipoprotein; Provisional; Region: PRK09967 871585007083 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 871585007084 ligand binding site [chemical binding]; other site 871585007085 phosphodiesterase YaeI; Provisional; Region: PRK11340 871585007086 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 871585007087 putative active site [active] 871585007088 putative metal binding site [ion binding]; other site 871585007089 Putative catalytic domain, repeat 1, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_1; cd09111 871585007090 putative active site [active] 871585007091 catalytic site [active] 871585007092 Putative catalytic domain, repeat 2, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_2; cd09113 871585007093 PLD-like domain; Region: PLDc_2; pfam13091 871585007094 putative active site [active] 871585007095 catalytic site [active] 871585007096 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 871585007097 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 871585007098 putative acyl-acceptor binding pocket; other site 871585007099 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 871585007100 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 871585007101 HflX GTPase family; Region: HflX; cd01878 871585007102 G1 box; other site 871585007103 GTP/Mg2+ binding site [chemical binding]; other site 871585007104 Switch I region; other site 871585007105 G2 box; other site 871585007106 G3 box; other site 871585007107 Switch II region; other site 871585007108 G4 box; other site 871585007109 G5 box; other site 871585007110 LrgB-like family; Region: LrgB; cl00596 871585007111 Uncharacterized protein conserved in bacteria (DUF2147); Region: DUF2147; pfam09917 871585007112 diadenosine tetraphosphatase; Reviewed; Region: apaH; PRK00166 871585007113 Escherichia coli ApaH and related proteins, metallophosphatase domain; Region: MPP_ApaH; cd07422 871585007114 active site 871585007115 metal binding site [ion binding]; metal-binding site 871585007116 potential frameshift: common BLAST hit: gi|213157955|ref|YP_002320753.1| dimethyladenosine transferase 871585007117 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 871585007118 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 871585007119 Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030 871585007120 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 871585007121 4-hydroxythreonine-4-phosphate dehydrogenase; Region: pdxA; TIGR00557 871585007122 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 871585007123 23S rRNA interface [nucleotide binding]; other site 871585007124 L3 interface [polypeptide binding]; other site 871585007125 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 871585007126 stringent starvation protein A; Provisional; Region: sspA; PRK09481 871585007127 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 871585007128 C-terminal, alpha helical domain of Stringent starvation protein A; Region: GST_C_SspA; cd03186 871585007129 dimer interface [polypeptide binding]; other site 871585007130 N-terminal domain interface [polypeptide binding]; other site 871585007131 ClpXP protease specificity-enhancing factor; Provisional; Region: PRK11798 871585007132 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 871585007133 G1 box; other site 871585007134 GTP/Mg2+ binding site [chemical binding]; other site 871585007135 G2 box; other site 871585007136 Switch I region; other site 871585007137 G3 box; other site 871585007138 Switch II region; other site 871585007139 G4 box; other site 871585007140 G5 box; other site 871585007141 Roadblock/LC7 domain; Region: Robl_LC7; smart00960 871585007142 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 871585007143 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 871585007144 ATP-grasp domain; Region: ATP-grasp_4; cl17255 871585007145 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785 871585007146 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 871585007147 carboxyltransferase (CT) interaction site; other site 871585007148 biotinylation site [posttranslational modification]; other site 871585007149 enoyl-CoA hydratase; Provisional; Region: PRK05995 871585007150 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 871585007151 substrate binding site [chemical binding]; other site 871585007152 oxyanion hole (OAH) forming residues; other site 871585007153 trimer interface [polypeptide binding]; other site 871585007154 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 871585007155 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 871585007156 active site 871585007157 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 871585007158 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 871585007159 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 871585007160 Trans-2-enoyl-CoA reductase (TER) and 2,4-dienoyl-CoA reductase (DECR), atypical (a) SDR; Region: TER_DECR_SDR_a; cd05369 871585007161 NAD(P) binding site [chemical binding]; other site 871585007162 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 871585007163 substrate binding site [chemical binding]; other site 871585007164 homotetramer interface [polypeptide binding]; other site 871585007165 active site 871585007166 homodimer interface [polypeptide binding]; other site 871585007167 Protein of unknown function (DUF1446); Region: DUF1446; pfam07287 871585007168 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 871585007169 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 871585007170 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 871585007171 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 871585007172 active site 871585007173 Protein of unknown function (DUF4256); Region: DUF4256; pfam14066 871585007174 Domain of unknown function (DUF2007); Region: DUF2007; pfam09413 871585007175 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 871585007176 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 871585007177 Protein involved in catabolism of external DNA [General function prediction only]; Region: ComJ; COG2961 871585007178 Predicted proline hydroxylase [Posttranslational modification, protein turnover, chaperones]; Region: EGL-9; COG3751 871585007179 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; pfam13640 871585007180 Protein of unknown function (DUF2789); Region: DUF2789; pfam10982 871585007181 malate dehydrogenase; Provisional; Region: PRK05442 871585007182 Chloroplast-like malate dehydrogenases; Region: MDH_choloroplast_like; cd01338 871585007183 NAD(P) binding site [chemical binding]; other site 871585007184 dimer interface [polypeptide binding]; other site 871585007185 malate binding site [chemical binding]; other site 871585007186 Ribonuclease T2 (RNase T2) is a widespread family of secreted RNases found in every organism examined thus far. This family includes RNase Rh, RNase MC1, RNase LE, and self-incompatibility RNases (S-RNases). Plant T2 RNases are expressed during leaf...; Region: RNase_T2_prok; cd01062 871585007187 B1 nucleotide binding pocket [chemical binding]; other site 871585007188 B2 nucleotide binding pocket [chemical binding]; other site 871585007189 CAS motifs; other site 871585007190 active site 871585007191 lytic murein transglycosylase; Provisional; Region: PRK11619 871585007192 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 871585007193 N-acetyl-D-glucosamine binding site [chemical binding]; other site 871585007194 catalytic residue [active] 871585007195 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325 871585007196 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 871585007197 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 871585007198 FeS/SAM binding site; other site 871585007199 TRAM domain; Region: TRAM; cl01282 871585007200 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 871585007201 PhoH-like protein; Region: PhoH; pfam02562 871585007202 metal-binding heat shock protein; Provisional; Region: PRK00016 871585007203 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 871585007204 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 871585007205 Protein of unknown function (DUF3108); Region: DUF3108; pfam11306 871585007206 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 871585007207 active site 871585007208 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 871585007209 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 871585007210 potential frameshift: common BLAST hit: gi|299768710|ref|YP_003730736.1| tRNA-processing ribonuclease BN(RNase BN) 871585007211 Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918 871585007212 Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918 871585007213 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 871585007214 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 871585007215 YcxB-like protein; Region: YcxB; pfam14317 871585007216 Nitroreductase-like family 4. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_4; cd02140 871585007217 dimer interface [polypeptide binding]; other site 871585007218 FMN binding site [chemical binding]; other site 871585007219 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 871585007220 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 871585007221 ribonuclease R; Region: RNase_R; TIGR02063 871585007222 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 871585007223 RNB domain; Region: RNB; pfam00773 871585007224 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 871585007225 RNA binding site [nucleotide binding]; other site 871585007226 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 871585007227 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 871585007228 active site 871585007229 Zn binding site [ion binding]; other site 871585007230 Probable metal-binding protein (DUF2387); Region: DUF2387; pfam09526 871585007231 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274 871585007232 rhomboid family GlyGly-CTERM serine protease; Region: rhom_GG_sort; TIGR03902 871585007233 Flavinator of succinate dehydrogenase; Region: Sdh5; pfam03937 871585007234 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 871585007235 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 871585007236 active site 871585007237 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 871585007238 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 871585007239 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 871585007240 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 871585007241 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 871585007242 alphaNTD homodimer interface [polypeptide binding]; other site 871585007243 alphaNTD - beta interaction site [polypeptide binding]; other site 871585007244 alphaNTD - beta' interaction site [polypeptide binding]; other site 871585007245 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 871585007246 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 871585007247 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 871585007248 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 871585007249 RNA binding surface [nucleotide binding]; other site 871585007250 30S ribosomal protein S11; Validated; Region: PRK05309 871585007251 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 871585007252 30S ribosomal protein S13; Region: bact_S13; TIGR03631 871585007253 Ribosomal protein L36; Region: Ribosomal_L36; pfam00444 871585007254 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 871585007255 SecY translocase; Region: SecY; pfam00344 871585007256 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 871585007257 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 871585007258 23S rRNA binding site [nucleotide binding]; other site 871585007259 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 871585007260 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 871585007261 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 871585007262 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 871585007263 5S rRNA interface [nucleotide binding]; other site 871585007264 23S rRNA interface [nucleotide binding]; other site 871585007265 L5 interface [polypeptide binding]; other site 871585007266 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 871585007267 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 871585007268 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 871585007269 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 871585007270 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 871585007271 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 871585007272 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 871585007273 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 871585007274 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 871585007275 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 871585007276 RNA binding site [nucleotide binding]; other site 871585007277 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 871585007278 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 871585007279 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 871585007280 23S rRNA interface [nucleotide binding]; other site 871585007281 putative translocon interaction site; other site 871585007282 signal recognition particle (SRP54) interaction site; other site 871585007283 L23 interface [polypeptide binding]; other site 871585007284 trigger factor interaction site; other site 871585007285 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 871585007286 23S rRNA interface [nucleotide binding]; other site 871585007287 5S rRNA interface [nucleotide binding]; other site 871585007288 putative antibiotic binding site [chemical binding]; other site 871585007289 L25 interface [polypeptide binding]; other site 871585007290 L27 interface [polypeptide binding]; other site 871585007291 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 871585007292 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 871585007293 G-X-X-G motif; other site 871585007294 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 871585007295 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 871585007296 putative translocon binding site; other site 871585007297 protein-rRNA interface [nucleotide binding]; other site 871585007298 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 871585007299 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 871585007300 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 871585007301 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 871585007302 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 871585007303 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 871585007304 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 871585007305 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 871585007306 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 871585007307 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 871585007308 catalytic triad [active] 871585007309 cystathionine beta-lyase; Provisional; Region: PRK07050 871585007310 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 871585007311 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 871585007312 catalytic residue [active] 871585007313 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 871585007314 Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872 871585007315 Walker A motif; other site 871585007316 ATP binding site [chemical binding]; other site 871585007317 Walker B motif; other site 871585007318 Zonular occludens toxin (Zot); Region: Zot; cl17485 871585007319 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 871585007320 heme-binding site [chemical binding]; other site 871585007321 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 871585007322 FAD binding pocket [chemical binding]; other site 871585007323 conserved FAD binding motif [chemical binding]; other site 871585007324 phosphate binding motif [ion binding]; other site 871585007325 Transcriptional regulator; Region: Rrf2; cl17282 871585007326 Rrf2 family protein; Region: rrf2_super; TIGR00738 871585007327 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 871585007328 G1 box; other site 871585007329 GTP/Mg2+ binding site [chemical binding]; other site 871585007330 Switch I region; other site 871585007331 G2 box; other site 871585007332 G3 box; other site 871585007333 Switch II region; other site 871585007334 G4 box; other site 871585007335 G5 box; other site 871585007336 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687 871585007337 Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118 871585007338 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 871585007339 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 871585007340 Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946 871585007341 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 871585007342 active site 871585007343 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 871585007344 catalytic triad [active] 871585007345 dimer interface [polypeptide binding]; other site 871585007346 glycerol-3-phosphate O-acyltransferase; Region: plsB; TIGR03703 871585007347 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Region: LPLAT_DHAPAT-like; cd07993 871585007348 putative acyl-acceptor binding pocket; other site 871585007349 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 871585007350 membrane-bound complex binding site; other site 871585007351 hinge residues; other site 871585007352 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 871585007353 NADH(P)-binding; Region: NAD_binding_10; pfam13460 871585007354 NAD(P) binding site [chemical binding]; other site 871585007355 active site 871585007356 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 871585007357 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 871585007358 ssDNA binding site; other site 871585007359 generic binding surface II; other site 871585007360 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 871585007361 ATP binding site [chemical binding]; other site 871585007362 putative Mg++ binding site [ion binding]; other site 871585007363 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 871585007364 nucleotide binding region [chemical binding]; other site 871585007365 ATP-binding site [chemical binding]; other site 871585007366 comF family protein; Region: comF; TIGR00201 871585007367 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 871585007368 active site 871585007369 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_31; cd04690 871585007370 nudix motif; other site 871585007371 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 871585007372 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 871585007373 Escherichia coli Mg2+ transporter CorA_like subgroup; Region: EcCorA-like_1; cd12835 871585007374 Cl binding site [ion binding]; other site 871585007375 oligomer interface [polypeptide binding]; other site 871585007376 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 871585007377 anti sigma factor interaction site; other site 871585007378 regulatory phosphorylation site [posttranslational modification]; other site 871585007379 Toluene tolerance, Ttg2; Region: Tol_Tol_Ttg2; pfam05494 871585007380 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 871585007381 mce related protein; Region: MCE; pfam02470 871585007382 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 871585007383 Permease; Region: Permease; cl00510 871585007384 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 871585007385 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 871585007386 Walker A/P-loop; other site 871585007387 ATP binding site [chemical binding]; other site 871585007388 Q-loop/lid; other site 871585007389 ABC transporter signature motif; other site 871585007390 Walker B; other site 871585007391 D-loop; other site 871585007392 H-loop/switch region; other site 871585007393 ATP-dependent RNA helicase RhlB; Provisional; Region: PRK04837 871585007394 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 871585007395 ATP binding site [chemical binding]; other site 871585007396 Mg++ binding site [ion binding]; other site 871585007397 motif III; other site 871585007398 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 871585007399 nucleotide binding region [chemical binding]; other site 871585007400 ATP-binding site [chemical binding]; other site 871585007401 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 871585007402 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 871585007403 active site 871585007404 dimerization interface [polypeptide binding]; other site 871585007405 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 871585007406 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 871585007407 TPP-binding site; other site 871585007408 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 871585007409 PYR/PP interface [polypeptide binding]; other site 871585007410 dimer interface [polypeptide binding]; other site 871585007411 TPP binding site [chemical binding]; other site 871585007412 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 871585007413 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 871585007414 dimerization interface [polypeptide binding]; other site 871585007415 active site 871585007416 coproporphyrinogen III oxidase; Provisional; Region: PRK05330 871585007417 Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; pfam01218 871585007418 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 871585007419 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 871585007420 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 871585007421 shikimate binding site; other site 871585007422 NAD(P) binding site [chemical binding]; other site 871585007423 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 871585007424 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 871585007425 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 871585007426 active site 871585007427 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 871585007428 PspC domain; Region: PspC; pfam04024 871585007429 CBS-domain-containing membrane protein [Signal transduction mechanisms]; Region: COG3448 871585007430 HPP family; Region: HPP; pfam04982 871585007431 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the HPP motif domain. These proteins are integral membrane proteins with four transmembrane spanning helices. The function of these proteins is...; Region: CBS_pair_HPP_assoc; cd04600 871585007432 probable DNA metabolism protein; Region: SAM_7_link_chp; TIGR03915 871585007433 putative DNA modification/repair radical SAM protein; Region: rSAM_link_UDG; TIGR03916 871585007434 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 871585007435 FeS/SAM binding site; other site 871585007436 Protein of unknown function (DUF1311); Region: DUF1311; pfam07007 871585007437 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 871585007438 dimer interface [polypeptide binding]; other site 871585007439 motif 1; other site 871585007440 active site 871585007441 motif 2; other site 871585007442 motif 3; other site 871585007443 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 871585007444 EamA-like transporter family; Region: EamA; pfam00892 871585007445 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 871585007446 EamA-like transporter family; Region: EamA; pfam00892 871585007447 Transcriptional regulator [Transcription]; Region: LysR; COG0583 871585007448 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 871585007449 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 871585007450 dimerization interface [polypeptide binding]; other site 871585007451 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 871585007452 aspartate racemase; Region: asp_race; TIGR00035 871585007453 cell density-dependent motility repressor; Provisional; Region: PRK10082 871585007454 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 871585007455 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 871585007456 dimerization interface [polypeptide binding]; other site 871585007457 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 871585007458 active site 871585007459 catalytic residues [active] 871585007460 Peptidase M14 Succinylglutamate desuccinylase (ASTE) subfamily; Region: M14_ASTE; cd03855 871585007461 Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952 871585007462 putative active site [active] 871585007463 Zn binding site [ion binding]; other site 871585007464 succinylarginine dihydrolase; Provisional; Region: PRK13281 871585007465 succinylglutamic semialdehyde dehydrogenase; Reviewed; Region: astD; PRK09457 871585007466 N-succinylglutamate 5-semialdehyde dehydrogenase, AstD-like; Region: ALDH_SGSD_AstD; cd07095 871585007467 NAD(P) binding site [chemical binding]; other site 871585007468 catalytic residues [active] 871585007469 Arginine N-succinyltransferase beta subunit; Region: AstA; cl11440 871585007470 Arginine/ornithine N-succinyltransferase beta subunit [Amino acid transport and metabolism]; Region: AstA; COG3138 871585007471 bifunctional succinylornithine transaminase/acetylornithine transaminase; Provisional; Region: PRK12381 871585007472 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 871585007473 inhibitor-cofactor binding pocket; inhibition site 871585007474 pyridoxal 5'-phosphate binding site [chemical binding]; other site 871585007475 catalytic residue [active] 871585007476 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 871585007477 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 871585007478 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 871585007479 NAD(P) binding site [chemical binding]; other site 871585007480 S-methylmethionine transporter; Provisional; Region: PRK11387 871585007481 Methyltransferase domain; Region: Methyltransf_23; pfam13489 871585007482 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 871585007483 S-adenosylmethionine binding site [chemical binding]; other site 871585007484 Endonuclease related to archaeal Holliday junction resolvase; Region: Endonuc_Holl; pfam10107 871585007485 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 871585007486 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 871585007487 P-loop; other site 871585007488 Magnesium ion binding site [ion binding]; other site 871585007489 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 871585007490 Domain of unknown function DUF20; Region: UPF0118; pfam01594 871585007491 Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032 871585007492 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 871585007493 E-class dimer interface [polypeptide binding]; other site 871585007494 P-class dimer interface [polypeptide binding]; other site 871585007495 active site 871585007496 Cu2+ binding site [ion binding]; other site 871585007497 Zn2+ binding site [ion binding]; other site 871585007498 FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805 871585007499 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 871585007500 multidrug efflux system translocase MdfA; Provisional; Region: PRK15402 871585007501 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 871585007502 putative substrate translocation pore; other site 871585007503 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 871585007504 Uncharacterized conserved protein [Function unknown]; Region: COG1359 871585007505 Bacteriophage abortive infection AbiH; Region: AbiH; pfam14253 871585007506 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 871585007507 FAD binding domain; Region: FAD_binding_4; pfam01565 871585007508 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790 871585007509 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_3; cd12176 871585007510 ligand binding site [chemical binding]; other site 871585007511 NAD binding site [chemical binding]; other site 871585007512 tetramer interface [polypeptide binding]; other site 871585007513 catalytic site [active] 871585007514 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 871585007515 L-serine binding site [chemical binding]; other site 871585007516 ACT domain interface; other site 871585007517 threonine and homoserine efflux system; Provisional; Region: PRK10532 871585007518 EamA-like transporter family; Region: EamA; pfam00892 871585007519 Threonine/homoserine efflux transporter [Amino acid transport and metabolism]; Region: rhtA; COG5006 871585007520 Hemerythrin-like domain; Region: Hr-like; cd12108 871585007521 hypothetical protein; Provisional; Region: PRK10621 871585007522 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 871585007523 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05033 871585007524 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 871585007525 RNA binding site [nucleotide binding]; other site 871585007526 active site 871585007527 Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157 871585007528 lipase chaperone; Provisional; Region: PRK01294 871585007529 Proteobacterial lipase chaperone protein; Region: Lipase_chap; pfam03280 871585007530 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 871585007531 Putative serine esterase (DUF676); Region: DUF676; pfam05057 871585007532 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 871585007533 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 871585007534 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 871585007535 RimM N-terminal domain; Region: RimM; pfam01782 871585007536 PRC-barrel domain; Region: PRC; pfam05239 871585007537 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 871585007538 Tfp pilus assembly protein PilE [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilE; COG4968 871585007539 Tfp pilus assembly protein PilE [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilE; COG4968 871585007540 von Willebrand factor type A domain; Region: VWA_2; pfam13519 871585007541 Neisseria PilC beta-propeller domain; Region: Neisseria_PilC; pfam05567 871585007542 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 871585007543 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 871585007544 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 871585007545 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 871585007546 catalytic site [active] 871585007547 G-X2-G-X-G-K; other site 871585007548 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 871585007549 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 871585007550 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 871585007551 Zn2+ binding site [ion binding]; other site 871585007552 Mg2+ binding site [ion binding]; other site 871585007553 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 871585007554 synthetase active site [active] 871585007555 NTP binding site [chemical binding]; other site 871585007556 metal binding site [ion binding]; metal-binding site 871585007557 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 871585007558 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 871585007559 ACT domain; Region: ACT_4; pfam13291 871585007560 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 871585007561 homotrimer interaction site [polypeptide binding]; other site 871585007562 putative active site [active] 871585007563 Bacterioferritin-associated ferredoxin [Inorganic ion transport and metabolism]; Region: Bfd; COG2906 871585007564 Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193 871585007565 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 871585007566 heme binding site [chemical binding]; other site 871585007567 ferroxidase pore; other site 871585007568 ferroxidase diiron center [ion binding]; other site 871585007569 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 871585007570 O-Antigen ligase; Region: Wzy_C; pfam04932 871585007571 Domain of unknown function (DUF3366); Region: DUF3366; pfam11846 871585007572 O-antigen ligase like membrane protein; Region: O-antigen_lig; pfam13425 871585007573 Tfp pilus assembly protein, major pilin PilA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilA; COG4969 871585007574 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 871585007575 Pilin (bacterial filament); Region: Pilin; pfam00114 871585007576 Repair protein; Region: Repair_PSII; pfam04536 871585007577 Repair protein; Region: Repair_PSII; pfam04536 871585007578 LemA family; Region: LemA; pfam04011 871585007579 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687 871585007580 Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118 871585007581 glutamate synthase small subunit family protein, proteobacterial; Region: gltD_gamma_fam; TIGR01318 871585007582 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 871585007583 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 871585007584 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 871585007585 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 871585007586 active site 871585007587 dimer interface [polypeptide binding]; other site 871585007588 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 871585007589 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 871585007590 active site 871585007591 FMN binding site [chemical binding]; other site 871585007592 substrate binding site [chemical binding]; other site 871585007593 3Fe-4S cluster binding site [ion binding]; other site 871585007594 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 871585007595 domain interface; other site 871585007596 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 871585007597 active site 871585007598 dimer interface [polypeptide binding]; other site 871585007599 metal binding site [ion binding]; metal-binding site 871585007600 shikimate kinase; Reviewed; Region: aroK; PRK00131 871585007601 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 871585007602 ADP binding site [chemical binding]; other site 871585007603 magnesium binding site [ion binding]; other site 871585007604 putative shikimate binding site; other site 871585007605 AMIN domain; Region: AMIN; pfam11741 871585007606 type IV pilus secretin (or competence protein) PilQ; Region: IV_pilus_PilQ; TIGR02515 871585007607 Secretin and TonB N terminus short domain; Region: STN; smart00965 871585007608 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 871585007609 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 871585007610 Tfp pilus assembly protein PilP [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilP; COG3168 871585007611 Pilus assembly protein, PilP; Region: PilP; pfam04351 871585007612 Pilus assembly protein, PilO; Region: PilO; pfam04350 871585007613 Tfp pilus assembly protein PilN [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilN; COG3166 871585007614 Fimbrial assembly protein (PilN); Region: PilN; pfam05137 871585007615 Competence protein A; Region: Competence_A; pfam11104 871585007616 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 871585007617 nucleotide binding site [chemical binding]; other site 871585007618 penicillin-binding protein 1a; Provisional; Region: mrcA; PRK11636 871585007619 Transglycosylase; Region: Transgly; pfam00912 871585007620 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 871585007621 23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088 871585007622 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 871585007623 S-adenosylmethionine binding site [chemical binding]; other site 871585007624 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 871585007625 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 871585007626 Mg++ binding site [ion binding]; other site 871585007627 putative catalytic motif [active] 871585007628 putative substrate binding site [chemical binding]; other site 871585007629 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 871585007630 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 871585007631 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 871585007632 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 871585007633 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 871585007634 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 871585007635 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 871585007636 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 871585007637 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 871585007638 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 871585007639 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 871585007640 Cell division protein FtsL; Region: FtsL; pfam04999 871585007641 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 871585007642 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 871585007643 S-adenosylmethionine binding site [chemical binding]; other site 871585007644 ABC-type sulfate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: Sbp; COG1613 871585007645 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 871585007646 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 871585007647 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 871585007648 active site 871585007649 HIGH motif; other site 871585007650 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 871585007651 active site 871585007652 KMSKS motif; other site 871585007653 S-methylmethionine transporter; Provisional; Region: PRK11387 871585007654 PGAP1-like protein; Region: PGAP1; pfam07819 871585007655 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 871585007656 heavy metal efflux pump, CzcA family; Region: 2A0601; TIGR00914 871585007657 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 871585007658 Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999 871585007659 HlyD family secretion protein; Region: HlyD_3; pfam13437 871585007660 Outer membrane efflux protein; Region: OEP; pfam02321 871585007661 Outer membrane efflux protein; Region: OEP; pfam02321 871585007662 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 871585007663 hypothetical protein; Provisional; Region: PRK10215 871585007664 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 871585007665 Sel1-like repeats; Region: SEL1; smart00671 871585007666 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 871585007667 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 871585007668 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 871585007669 ABC transporter; Region: ABC_tran_2; pfam12848 871585007670 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 871585007671 O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK06084 871585007672 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 871585007673 homodimer interface [polypeptide binding]; other site 871585007674 substrate-cofactor binding pocket; other site 871585007675 pyridoxal 5'-phosphate binding site [chemical binding]; other site 871585007676 catalytic residue [active] 871585007677 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 871585007678 classical (c) SDRs; Region: SDR_c; cd05233 871585007679 NAD(P) binding site [chemical binding]; other site 871585007680 active site 871585007681 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 871585007682 Sulfate transporter family; Region: Sulfate_transp; pfam00916 871585007683 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378 871585007684 active site clefts [active] 871585007685 zinc binding site [ion binding]; other site 871585007686 dimer interface [polypeptide binding]; other site 871585007687 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 871585007688 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 871585007689 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 871585007690 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 871585007691 RNA binding site [nucleotide binding]; other site 871585007692 osmolarity response regulator; Provisional; Region: ompR; PRK09468 871585007693 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 871585007694 active site 871585007695 phosphorylation site [posttranslational modification] 871585007696 intermolecular recognition site; other site 871585007697 dimerization interface [polypeptide binding]; other site 871585007698 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 871585007699 DNA binding site [nucleotide binding] 871585007700 osmolarity sensor protein; Provisional; Region: envZ; PRK09467 871585007701 HAMP domain; Region: HAMP; pfam00672 871585007702 dimerization interface [polypeptide binding]; other site 871585007703 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 871585007704 dimer interface [polypeptide binding]; other site 871585007705 phosphorylation site [posttranslational modification] 871585007706 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 871585007707 ATP binding site [chemical binding]; other site 871585007708 Mg2+ binding site [ion binding]; other site 871585007709 G-X-G motif; other site 871585007710 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 871585007711 succinate CoA transferase; Region: YgfH_subfam; TIGR03458 871585007712 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 871585007713 putative acetyltransferase; Provisional; Region: PRK03624 871585007714 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 871585007715 Coenzyme A binding pocket [chemical binding]; other site 871585007716 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 871585007717 Coenzyme A binding pocket [chemical binding]; other site 871585007718 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 871585007719 putative active site pocket [active] 871585007720 4-fold oligomerization interface [polypeptide binding]; other site 871585007721 metal binding residues [ion binding]; metal-binding site 871585007722 3-fold/trimer interface [polypeptide binding]; other site 871585007723 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141 871585007724 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 871585007725 putative active site [active] 871585007726 oxyanion strand; other site 871585007727 catalytic triad [active] 871585007728 Protein of unknown function (DUF805); Region: DUF805; pfam05656 871585007729 DEDDy 3'-5' exonuclease domain of WRN and similar proteins; Region: WRN_exo; cd06141 871585007730 catalytic site [active] 871585007731 putative active site [active] 871585007732 putative substrate binding site [chemical binding]; other site 871585007733 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 871585007734 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 871585007735 catalytic residues [active] 871585007736 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 871585007737 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 871585007738 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 871585007739 Walker A/P-loop; other site 871585007740 ATP binding site [chemical binding]; other site 871585007741 Q-loop/lid; other site 871585007742 ABC transporter signature motif; other site 871585007743 Walker B; other site 871585007744 D-loop; other site 871585007745 H-loop/switch region; other site 871585007746 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 871585007747 non-specific DNA binding site [nucleotide binding]; other site 871585007748 salt bridge; other site 871585007749 sequence-specific DNA binding site [nucleotide binding]; other site 871585007750 Cupin domain; Region: Cupin_2; pfam07883 871585007751 EamA-like transporter family; Region: EamA; pfam00892 871585007752 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 871585007753 Predicted membrane protein [Function unknown]; Region: COG3671 871585007754 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 871585007755 DNA-binding site [nucleotide binding]; DNA binding site 871585007756 RNA-binding motif; other site 871585007757 Protein of unknown function (DUF1294); Region: DUF1294; pfam06961 871585007758 Homoserine Kinase, type II. Homoserine kinase is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and...; Region: HomoserineK_II; cd05153 871585007759 Phosphotransferase enzyme family; Region: APH; pfam01636 871585007760 putative active site [active] 871585007761 putative substrate binding site [chemical binding]; other site 871585007762 ATP binding site [chemical binding]; other site 871585007763 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 871585007764 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 871585007765 substrate binding site [chemical binding]; other site 871585007766 glutamase interaction surface [polypeptide binding]; other site 871585007767 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 871585007768 Helix-turn-helix domain; Region: HTH_18; pfam12833 871585007769 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 871585007770 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 871585007771 amphipathic channel; other site 871585007772 Asn-Pro-Ala signature motifs; other site 871585007773 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 871585007774 DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases. They exists as monomers and homodimers; Region: NUC; cd00091 871585007775 DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892 871585007776 active site 871585007777 substrate binding site [chemical binding]; other site 871585007778 Mg2+ binding site [ion binding]; other site 871585007779 K+ transporter [Inorganic ion transport and metabolism]; Region: Kup; COG3158 871585007780 potassium uptake protein; Region: kup; TIGR00794 871585007781 Transcriptional repressor [Transcription]; Region: MOT2; COG5175 871585007782 Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525 871585007783 Predicted transcriptional regulators [Transcription]; Region: COG1733 871585007784 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 871585007785 fosfomycin resistance protein FosB; Provisional; Region: PRK04101 871585007786 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 871585007787 active site 871585007788 metal binding site [ion binding]; metal-binding site 871585007789 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 871585007790 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 871585007791 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 871585007792 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 871585007793 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 871585007794 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 871585007795 active site 871585007796 catalytic tetrad [active] 871585007797 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 871585007798 EamA-like transporter family; Region: EamA; pfam00892 871585007799 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 871585007800 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 871585007801 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 871585007802 dimerization interface [polypeptide binding]; other site 871585007803 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 871585007804 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 871585007805 putative substrate translocation pore; other site 871585007806 Glutathione-dependent formaldehyde-activating enzyme; Region: GFA; pfam04828 871585007807 Methyltransferase domain; Region: Methyltransf_23; pfam13489 871585007808 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 871585007809 S-adenosylmethionine binding site [chemical binding]; other site 871585007810 Predicted NAD/FAD-binding protein [General function prediction only]; Region: COG2907 871585007811 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 871585007812 Pirin-related protein [General function prediction only]; Region: COG1741 871585007813 Pirin; Region: Pirin; pfam02678 871585007814 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 871585007815 Isochorismatase family; Region: Isochorismatase; pfam00857 871585007816 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 871585007817 catalytic triad [active] 871585007818 dimer interface [polypeptide binding]; other site 871585007819 conserved cis-peptide bond; other site 871585007820 LysR family transcriptional regulator; Provisional; Region: PRK14997 871585007821 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 871585007822 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 871585007823 dimerization interface [polypeptide binding]; other site 871585007824 succinic semialdehyde dehydrogenase; Region: PLN02278 871585007825 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 871585007826 tetramerization interface [polypeptide binding]; other site 871585007827 NAD(P) binding site [chemical binding]; other site 871585007828 catalytic residues [active] 871585007829 4-aminobutyrate aminotransferase; Provisional; Region: PRK06777 871585007830 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 871585007831 inhibitor-cofactor binding pocket; inhibition site 871585007832 pyridoxal 5'-phosphate binding site [chemical binding]; other site 871585007833 catalytic residue [active] 871585007834 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 871585007835 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 871585007836 DNA-binding site [nucleotide binding]; DNA binding site 871585007837 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 871585007838 pyridoxal 5'-phosphate binding site [chemical binding]; other site 871585007839 homodimer interface [polypeptide binding]; other site 871585007840 catalytic residue [active] 871585007841 potential frameshift: common BLAST hit: gi|215481957|ref|YP_002324139.1| GABA permease (4-amino butyrate transport carrier) 871585007842 gamma-aminobutyrate permease; Region: GABAperm; TIGR01773 871585007843 Spore germination protein; Region: Spore_permease; cl17796 871585007844 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 871585007845 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 871585007846 non-specific DNA binding site [nucleotide binding]; other site 871585007847 salt bridge; other site 871585007848 sequence-specific DNA binding site [nucleotide binding]; other site 871585007849 Cupin domain; Region: Cupin_2; pfam07883 871585007850 AzlC protein; Region: AzlC; cl00570 871585007851 Branched-chain amino acid transport protein (AzlD); Region: AzlD; pfam05437 871585007852 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 871585007853 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 871585007854 dimer interface [polypeptide binding]; other site 871585007855 ssDNA binding site [nucleotide binding]; other site 871585007856 tetramer (dimer of dimers) interface [polypeptide binding]; other site 871585007857 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 871585007858 Major Facilitator Superfamily; Region: MFS_1; pfam07690 871585007859 putative substrate translocation pore; other site 871585007860 hypothetical protein; Provisional; Region: PRK14013 871585007861 Putative transcription activator [Transcription]; Region: TenA; COG0819 871585007862 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 871585007863 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 871585007864 DNA binding residues [nucleotide binding] 871585007865 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 871585007866 classical (c) SDRs; Region: SDR_c; cd05233 871585007867 NAD(P) binding site [chemical binding]; other site 871585007868 active site 871585007869 GlpM protein; Region: GlpM; pfam06942 871585007870 Protein of unknown function (DUF1304); Region: DUF1304; pfam06993 871585007871 2-enoyl thioester reductase (ETR) like proteins, child 2; Region: ETR_like_2; cd08292 871585007872 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 871585007873 putative NAD(P) binding site [chemical binding]; other site 871585007874 putative dimer interface [polypeptide binding]; other site 871585007875 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 871585007876 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 871585007877 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 871585007878 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 871585007879 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 871585007880 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 871585007881 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 871585007882 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 871585007883 metal binding site [ion binding]; metal-binding site 871585007884 active site 871585007885 I-site; other site 871585007886 BCCT family transporter; Region: BCCT; pfam02028 871585007887 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 871585007888 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 871585007889 Na binding site [ion binding]; other site 871585007890 Protein of unknown function, DUF485; Region: DUF485; pfam04341 871585007891 Na+/proline symporter [Amino acid transport and metabolism / General function prediction only]; Region: PutP; COG0591 871585007892 Na binding site [ion binding]; other site 871585007893 PAS fold; Region: PAS_7; pfam12860 871585007894 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 871585007895 putative active site [active] 871585007896 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 871585007897 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 871585007898 dimer interface [polypeptide binding]; other site 871585007899 phosphorylation site [posttranslational modification] 871585007900 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 871585007901 ATP binding site [chemical binding]; other site 871585007902 Mg2+ binding site [ion binding]; other site 871585007903 G-X-G motif; other site 871585007904 Response regulator receiver domain; Region: Response_reg; pfam00072 871585007905 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 871585007906 active site 871585007907 phosphorylation site [posttranslational modification] 871585007908 intermolecular recognition site; other site 871585007909 dimerization interface [polypeptide binding]; other site 871585007910 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 871585007911 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 871585007912 active site 871585007913 phosphorylation site [posttranslational modification] 871585007914 intermolecular recognition site; other site 871585007915 dimerization interface [polypeptide binding]; other site 871585007916 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 871585007917 DNA binding residues [nucleotide binding] 871585007918 dimerization interface [polypeptide binding]; other site 871585007919 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 871585007920 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 871585007921 dimethyl sulfone monooxygenase SfnG; Region: LLM_DMSO2_sfnG; TIGR04021 871585007922 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 871585007923 active site 871585007924 dimer interface [polypeptide binding]; other site 871585007925 non-prolyl cis peptide bond; other site 871585007926 insertion regions; other site 871585007927 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 871585007928 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 871585007929 putative DNA binding site [nucleotide binding]; other site 871585007930 putative Zn2+ binding site [ion binding]; other site 871585007931 AsnC family; Region: AsnC_trans_reg; pfam01037 871585007932 Isochorismatase family; Region: Isochorismatase; pfam00857 871585007933 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 871585007934 catalytic triad [active] 871585007935 conserved cis-peptide bond; other site 871585007936 potential frameshift: common BLAST hit: gi|299768418|ref|YP_003730444.1| acetate--CoA ligase 871585007937 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 871585007938 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 871585007939 AMP-binding enzyme; Region: AMP-binding; pfam00501 871585007940 active site 871585007941 CoA binding site [chemical binding]; other site 871585007942 acyl-activating enzyme (AAE) consensus motif; other site 871585007943 AMP binding site [chemical binding]; other site 871585007944 acetate binding site [chemical binding]; other site 871585007945 Protein of unknown function (DUF805); Region: DUF805; pfam05656 871585007946 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 871585007947 Mechanosensitive ion channel; Region: MS_channel; pfam00924 871585007948 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 871585007949 3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749 871585007950 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 871585007951 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 871585007952 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 871585007953 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 871585007954 FMN binding site [chemical binding]; other site 871585007955 active site 871585007956 substrate binding site [chemical binding]; other site 871585007957 catalytic residue [active] 871585007958 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 871585007959 putative DNA binding site [nucleotide binding]; other site 871585007960 dimerization interface [polypeptide binding]; other site 871585007961 putative Zn2+ binding site [ion binding]; other site 871585007962 peptide chain release factor 2; Provisional; Region: PRK08787 871585007963 This domain is found in peptide chain release factors; Region: PCRF; smart00937 871585007964 RF-1 domain; Region: RF-1; pfam00472 871585007965 ssDNA exonuclease RecJ; Provisional; Region: PRK11070 871585007966 DHH family; Region: DHH; pfam01368 871585007967 DHHA1 domain; Region: DHHA1; pfam02272 871585007968 pyridoxamine-phosphate oxidase; Region: pdxH; TIGR00558 871585007969 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 871585007970 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 871585007971 phosphoglucosamine mutase; Provisional; Region: glmM; PRK10887 871585007972 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 871585007973 active site 871585007974 substrate binding site [chemical binding]; other site 871585007975 metal binding site [ion binding]; metal-binding site 871585007976 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 871585007977 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 871585007978 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 871585007979 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 871585007980 active site 871585007981 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 871585007982 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 871585007983 ferrichrome outer membrane transporter; Provisional; Region: PRK10044 871585007984 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 871585007985 N-terminal plug; other site 871585007986 ligand-binding site [chemical binding]; other site 871585007987 Predicted membrane protein [Function unknown]; Region: COG2119 871585007988 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 871585007989 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 871585007990 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 871585007991 pyruvate dehydrogenase dihydrolipoyltransacetylase; Validated; Region: aceF; PRK11854 871585007992 E3 interaction surface; other site 871585007993 lipoyl attachment site [posttranslational modification]; other site 871585007994 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 871585007995 E3 interaction surface; other site 871585007996 lipoyl attachment site [posttranslational modification]; other site 871585007997 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 871585007998 E3 interaction surface; other site 871585007999 lipoyl attachment site [posttranslational modification]; other site 871585008000 e3 binding domain; Region: E3_binding; pfam02817 871585008001 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 871585008002 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 871585008003 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 871585008004 dimer interface [polypeptide binding]; other site 871585008005 TPP-binding site [chemical binding]; other site 871585008006 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 871585008007 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 871585008008 Peptidase family M23; Region: Peptidase_M23; pfam01551 871585008009 Protein of unknown function (DUF721); Region: DUF721; cl02324 871585008010 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186 871585008011 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 871585008012 cell division protein FtsZ; Validated; Region: PRK09330 871585008013 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 871585008014 nucleotide binding site [chemical binding]; other site 871585008015 SulA interaction site; other site 871585008016 Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849 871585008017 Cell division protein FtsA; Region: FtsA; smart00842 871585008018 Cell division protein FtsA; Region: FtsA; pfam14450 871585008019 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 871585008020 Cell division protein FtsQ; Region: FtsQ; pfam03799 871585008021 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 871585008022 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 871585008023 ATP-grasp domain; Region: ATP-grasp_4; cl17255 871585008024 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 871585008025 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 871585008026 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 871585008027 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 871585008028 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 871585008029 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 871585008030 active site 871585008031 homodimer interface [polypeptide binding]; other site 871585008032 glutathione synthetase; Provisional; Region: PRK05246 871585008033 Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951 871585008034 Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955 871585008035 Domain of unknown function (DUF1737); Region: DUF1737; pfam08410 871585008036 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 871585008037 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 871585008038 N-terminal plug; other site 871585008039 ligand-binding site [chemical binding]; other site 871585008040 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 871585008041 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 871585008042 Helix-turn-helix domain; Region: HTH_18; pfam12833 871585008043 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 871585008044 active site 871585008045 Neisseria meningitides Nape-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Nape_like_AP-endo; cd10281 871585008046 putative active site [active] 871585008047 putative catalytic site [active] 871585008048 putative DNA binding site [nucleotide binding]; other site 871585008049 putative phosphate binding site [ion binding]; other site 871585008050 metal binding site A [ion binding]; metal-binding site 871585008051 putative AP binding site [nucleotide binding]; other site 871585008052 putative metal binding site B [ion binding]; other site 871585008053 Arsenate Reductase (ArsC) family, Yffb subfamily; Yffb is an uncharacterized bacterial protein encoded by the yffb gene, related to the thioredoxin-fold arsenic reductases, ArsC. The structure of Yffb and the conservation of the catalytic cysteine...; Region: ArsC_Yffb; cd03035 871585008054 ArsC family; Region: ArsC; pfam03960 871585008055 putative catalytic residues [active] 871585008056 Uncharacterized protein conserved in bacteria (DUF2147); Region: DUF2147; pfam09917 871585008057 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 871585008058 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 871585008059 Glutathionylspermidine synthase preATP-grasp; Region: GSP_synth; cl00503 871585008060 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 871585008061 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 871585008062 metal binding site [ion binding]; metal-binding site 871585008063 active site 871585008064 I-site; other site 871585008065 thiol:disulfide interchange protein precursor; Provisional; Region: dipZ; PRK00293 871585008066 Disulphide bond corrector protein DsbC; Region: DsbC; pfam11412 871585008067 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 871585008068 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 871585008069 Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; pfam13557 871585008070 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 871585008071 Ankyrin repeats (many copies); Region: Ank_5; pfam13857 871585008072 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cl00250 871585008073 30S subunit binding site; other site 871585008074 putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212 871585008075 Catalytic domain of bacterial PuuE allantoinases, Schizosaccharomyces pombe chitin deacetylase 1 (SpCDA1), and similar proteins; Region: CE4_PuuE_SpCDA1; cd10977 871585008076 active site 871585008077 catalytic site [active] 871585008078 tetramer interface [polypeptide binding]; other site 871585008079 putative OHCU decarboxylase; Provisional; Region: PRK13798 871585008080 HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822 871585008081 active site 871585008082 homotetramer interface [polypeptide binding]; other site 871585008083 xanthine permease; Region: pbuX; TIGR03173 871585008084 Nucleoside-specific channel-forming protein, Tsx; Region: Channel_Tsx; cl04114 871585008085 hypothetical protein; Provisional; Region: PRK07538 871585008086 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 871585008087 allantoicase; Region: allantoicase; TIGR02961 871585008088 Allantoicase repeat; Region: Allantoicase; pfam03561 871585008089 Allantoicase repeat; Region: Allantoicase; pfam03561 871585008090 ureidoglycolate hydrolase; Provisional; Region: PRK03606 871585008091 Ureidoglycolate hydrolase [Nucleotide transport and metabolism]; Region: DAL3; COG3194 871585008092 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 871585008093 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 871585008094 ATP binding site [chemical binding]; other site 871585008095 Mg2+ binding site [ion binding]; other site 871585008096 G-X-G motif; other site 871585008097 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 871585008098 anchoring element; other site 871585008099 dimer interface [polypeptide binding]; other site 871585008100 ATP binding site [chemical binding]; other site 871585008101 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 871585008102 active site 871585008103 metal binding site [ion binding]; metal-binding site 871585008104 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 871585008105 Uncharacterized protein family (UPF0227); Region: UPF0227; cl14886 871585008106 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 871585008107 PGAP1-like protein; Region: PGAP1; pfam07819 871585008108 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 871585008109 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 871585008110 Uncharacterized protein conserved in bacteria [Function unknown]; Region: VgrG; COG3501 871585008111 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 871585008112 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 871585008113 Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296 871585008114 Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; pfam10106 871585008115 Disulfide bond formation protein DsbB; Region: DsbB; pfam02600 871585008116 Glutamate-cysteine ligase; Region: Glu_cys_ligase; cl17352 871585008117 Bacterial protein of unknown function (DUF924); Region: DUF924; pfam06041 871585008118 Protein of unknown function (DUF445); Region: DUF445; pfam04286 871585008119 methionine aminotransferase; Validated; Region: PRK09082 871585008120 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 871585008121 pyridoxal 5'-phosphate binding site [chemical binding]; other site 871585008122 homodimer interface [polypeptide binding]; other site 871585008123 catalytic residue [active] 871585008124 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138 871585008125 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 871585008126 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 871585008127 short chain dehydrogenase; Provisional; Region: PRK07832 871585008128 NAD(P) binding site [chemical binding]; other site 871585008129 active site 871585008130 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 871585008131 phosphate regulon transcriptional regulatory protein PhoB; Region: PhoB; TIGR02154 871585008132 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 871585008133 active site 871585008134 phosphorylation site [posttranslational modification] 871585008135 intermolecular recognition site; other site 871585008136 dimerization interface [polypeptide binding]; other site 871585008137 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 871585008138 DNA binding site [nucleotide binding] 871585008139 Domain of unknown function (DUF3329); Region: DUF3329; pfam11808 871585008140 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 871585008141 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 871585008142 putative active site [active] 871585008143 heme pocket [chemical binding]; other site 871585008144 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 871585008145 dimer interface [polypeptide binding]; other site 871585008146 phosphorylation site [posttranslational modification] 871585008147 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 871585008148 ATP binding site [chemical binding]; other site 871585008149 Mg2+ binding site [ion binding]; other site 871585008150 G-X-G motif; other site 871585008151 Secretory lipase; Region: LIP; pfam03583 871585008152 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 871585008153 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 871585008154 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 871585008155 Predicted acetamidase/formamidase [Energy production and conversion]; Region: COG2421 871585008156 phosphatidylserine decarboxylase; Reviewed; Region: psd; PRK00044 871585008157 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 871585008158 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 871585008159 active site residue [active] 871585008160 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 871585008161 active site residue [active] 871585008162 nicotinate phosphoribosyltransferase; Provisional; Region: PRK05321 871585008163 Nicotinate phosphoribosyltransferase (NAPRTase) family; Region: NAPRTase; pfam04095 871585008164 active site 871585008165 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 871585008166 putative active site [active] 871585008167 dimerization interface [polypeptide binding]; other site 871585008168 putative tRNAtyr binding site [nucleotide binding]; other site 871585008169 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 871585008170 ACT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_2; cd04871 871585008171 phosphoserine phosphatase SerB; Region: serB; TIGR00338 871585008172 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 871585008173 motif II; other site 871585008174 Domain of unknown function (DUF4175); Region: DUF4175; pfam13779 871585008175 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II-like protein; Provisional; Region: PRK14019 871585008176 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 871585008177 GTP cyclohydrolase II; Region: GTP_cyclohydro2; pfam00925 871585008178 dimerization interface [polypeptide binding]; other site 871585008179 active site 871585008180 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 871585008181 homopentamer interface [polypeptide binding]; other site 871585008182 active site 871585008183 transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202 871585008184 thiamine monophosphate kinase; Provisional; Region: PRK05731 871585008185 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 871585008186 ATP binding site [chemical binding]; other site 871585008187 dimerization interface [polypeptide binding]; other site 871585008188 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 871585008189 tetramer interfaces [polypeptide binding]; other site 871585008190 binuclear metal-binding site [ion binding]; other site 871585008191 N-acetylglucosamine-1-phosphate uridyltransferase (contains nucleotidyltransferase and I-patch acetyltransferase domains) [Cell envelope biogenesis, outer membrane]; Region: GlmU; COG1207 871585008192 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 871585008193 Substrate binding site; other site 871585008194 Mg++ binding site; other site 871585008195 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 871585008196 active site 871585008197 substrate binding site [chemical binding]; other site 871585008198 CoA binding site [chemical binding]; other site 871585008199 Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319 871585008200 active site 871585008201 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 871585008202 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 871585008203 dimer interface [polypeptide binding]; other site 871585008204 active site 871585008205 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 871585008206 dimer interface [polypeptide binding]; other site 871585008207 active site 871585008208 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 871585008209 glutamate racemase; Provisional; Region: PRK00865 871585008210 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 871585008211 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 871585008212 motif II; other site 871585008213 Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960 871585008214 agmatinase; Region: agmatinase; TIGR01230 871585008215 Formimidoylglutamase or HutE; Region: Formimidoylglutamase; cd09988 871585008216 putative active site [active] 871585008217 putative metal binding site [ion binding]; other site 871585008218 imidazolonepropionase; Validated; Region: PRK09356 871585008219 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296 871585008220 active site 871585008221 putative proline-specific permease; Provisional; Region: proY; PRK10580 871585008222 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 871585008223 active sites [active] 871585008224 tetramer interface [polypeptide binding]; other site 871585008225 urocanate hydratase; Provisional; Region: PRK05414 871585008226 HutD; Region: HutD; pfam05962 871585008227 histidine utilization repressor, proteobacterial; Region: his_ut_repres; TIGR02018 871585008228 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 871585008229 DNA-binding site [nucleotide binding]; DNA binding site 871585008230 UTRA domain; Region: UTRA; pfam07702 871585008231 Acyltransferase family; Region: Acyl_transf_3; pfam01757 871585008232 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 871585008233 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 871585008234 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 871585008235 Peptidase M15; Region: Peptidase_M15_3; cl01194 871585008236 aromatic amino acid transporter; Provisional; Region: PRK10238 871585008237 fumarylacetoacetase; Region: PLN02856 871585008238 Domain of unknown function (DUF1969); Region: DUF1969; pfam09298 871585008239 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 871585008240 GST_N family, Class Zeta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Zeta; cd03042 871585008241 maleylacetoacetate isomerase; Region: maiA; TIGR01262 871585008242 C-terminal domain interface [polypeptide binding]; other site 871585008243 GSH binding site (G-site) [chemical binding]; other site 871585008244 putative dimer interface [polypeptide binding]; other site 871585008245 C-terminal, alpha helical domain of Class Zeta Glutathione S-transferases; Region: GST_C_Zeta; cd03191 871585008246 dimer interface [polypeptide binding]; other site 871585008247 N-terminal domain interface [polypeptide binding]; other site 871585008248 maleylacetoacetate (MAA) substrate binding site (H site) [chemical binding]; other site 871585008249 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 871585008250 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 871585008251 Zn binding site [ion binding]; other site 871585008252 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 871585008253 Transcriptional regulator [Transcription]; Region: IclR; COG1414 871585008254 Bacterial transcriptional regulator; Region: IclR; pfam01614 871585008255 4-hydroxyphenylpyruvate dioxygenase and related hemolysins [Amino acid transport and metabolism / General function prediction only]; Region: COG3185 871585008256 N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342 871585008257 dimer interface [polypeptide binding]; other site 871585008258 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250 871585008259 active site 871585008260 Fe binding site [ion binding]; other site 871585008261 Uncharacterized conserved protein [Function unknown]; Region: COG1683 871585008262 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 871585008263 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 871585008264 cation binding site [ion binding]; other site 871585008265 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 871585008266 Sodium Bile acid symporter family; Region: SBF; pfam01758 871585008267 Isochorismatase family; Region: Isochorismatase; pfam00857 871585008268 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 871585008269 catalytic triad [active] 871585008270 metal binding site [ion binding]; metal-binding site 871585008271 conserved cis-peptide bond; other site 871585008272 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 871585008273 dihydrodipicolinate synthase; Region: dapA; TIGR00674 871585008274 dimer interface [polypeptide binding]; other site 871585008275 active site 871585008276 catalytic residue [active] 871585008277 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 871585008278 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 871585008279 ATP binding site [chemical binding]; other site 871585008280 active site 871585008281 substrate binding site [chemical binding]; other site 871585008282 Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226 871585008283 recombination factor protein RarA; Reviewed; Region: PRK13342 871585008284 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 871585008285 Walker A motif; other site 871585008286 ATP binding site [chemical binding]; other site 871585008287 Walker B motif; other site 871585008288 arginine finger; other site 871585008289 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 871585008290 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 871585008291 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 871585008292 hypothetical protein; Provisional; Region: PRK05170 871585008293 Small integral membrane protein [Function unknown]; Region: COG5487; cl17674 871585008294 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 871585008295 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 871585008296 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 871585008297 nucleotide binding site/active site [active] 871585008298 HIT family signature motif; other site 871585008299 catalytic residue [active] 871585008300 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 871585008301 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 871585008302 minor groove reading motif; other site 871585008303 helix-hairpin-helix signature motif; other site 871585008304 substrate binding pocket [chemical binding]; other site 871585008305 active site 871585008306 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 871585008307 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 871585008308 DNA binding and oxoG recognition site [nucleotide binding] 871585008309 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 871585008310 Peptidase family M23; Region: Peptidase_M23; pfam01551 871585008311 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 871585008312 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 871585008313 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 871585008314 putative NAD(P) binding site [chemical binding]; other site 871585008315 putative substrate binding site [chemical binding]; other site 871585008316 catalytic Zn binding site [ion binding]; other site 871585008317 structural Zn binding site [ion binding]; other site 871585008318 dimer interface [polypeptide binding]; other site 871585008319 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 871585008320 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 871585008321 DNA-binding site [nucleotide binding]; DNA binding site 871585008322 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 871585008323 pyridoxal 5'-phosphate binding site [chemical binding]; other site 871585008324 homodimer interface [polypeptide binding]; other site 871585008325 catalytic residue [active] 871585008326 Transcriptional regulator [Transcription]; Region: LysR; COG0583 871585008327 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 871585008328 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA; cd08478 871585008329 putative effector binding pocket; other site 871585008330 dimerization interface [polypeptide binding]; other site 871585008331 potential frameshift: common BLAST hit: gi|169794242|ref|YP_001712035.1| 2,5-diketo-D-gluconate reductase B 871585008332 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 871585008333 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 871585008334 catalytic tetrad [active] 871585008335 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cl00470 871585008336 active site 871585008337 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 871585008338 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 871585008339 putative substrate translocation pore; other site 871585008340 Uncharacterized subgroup of the steroidogenic acute regulatory protein (StAR)-related lipid transfer (START) domain family; Region: START_1; cd08876 871585008341 putative lipid binding site [chemical binding]; other site 871585008342 dihydrodipicolinate reductase; Provisional; Region: PRK00048 871585008343 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 871585008344 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 871585008345 chaperone protein DnaJ; Provisional; Region: PRK10767 871585008346 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 871585008347 HSP70 interaction site [polypeptide binding]; other site 871585008348 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 871585008349 substrate binding site [polypeptide binding]; other site 871585008350 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 871585008351 Zn binding sites [ion binding]; other site 871585008352 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 871585008353 dimer interface [polypeptide binding]; other site 871585008354 Inorganic H+ pyrophosphatase; Region: H_PPase; pfam03030 871585008355 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 871585008356 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 871585008357 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 871585008358 HlyD family secretion protein; Region: HlyD_3; pfam13437 871585008359 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 871585008360 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 871585008361 phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009 871585008362 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 871585008363 pyrimidine utilization transport protein G; Region: RutG; TIGR03616 871585008364 Transcriptional regulator [Transcription]; Region: LysR; COG0583 871585008365 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 871585008366 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 871585008367 dimerization interface [polypeptide binding]; other site 871585008368 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 871585008369 dihydroxy-acid dehydratase; Provisional; Region: PRK12448 871585008370 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 871585008371 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 871585008372 putative active site [active] 871585008373 substrate binding site [chemical binding]; other site 871585008374 putative cosubstrate binding site; other site 871585008375 catalytic site [active] 871585008376 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 871585008377 substrate binding site [chemical binding]; other site 871585008378 16S rRNA methyltransferase B; Provisional; Region: PRK10901 871585008379 NusB family; Region: NusB; pfam01029 871585008380 putative RNA binding site [nucleotide binding]; other site 871585008381 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 871585008382 S-adenosylmethionine binding site [chemical binding]; other site 871585008383 uncharacterized bacterial and archaeal solute carrier 6 subfamily; solute-binding domain; Region: SLC6sbd_u1; cd10334 871585008384 Na2 binding site [ion binding]; other site 871585008385 putative substrate binding site 1 [chemical binding]; other site 871585008386 Na binding site 1 [ion binding]; other site 871585008387 putative substrate binding site 2 [chemical binding]; other site 871585008388 outer membrane protein; Region: OMP_w_GlyGly; TIGR04219 871585008389 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 871585008390 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 871585008391 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 871585008392 dimer interface [polypeptide binding]; other site 871585008393 N-terminal domain interface [polypeptide binding]; other site 871585008394 substrate binding pocket (H-site) [chemical binding]; other site 871585008395 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 871585008396 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 871585008397 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 871585008398 Predicted flavoprotein [General function prediction only]; Region: COG0431 871585008399 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 871585008400 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 871585008401 FKBP-type peptidyl-prolyl cis-trans isomerases 2 [Posttranslational modification, protein turnover, chaperones]; Region: SlpA; COG1047 871585008402 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 871585008403 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 871585008404 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 871585008405 active site 871585008406 HIGH motif; other site 871585008407 nucleotide binding site [chemical binding]; other site 871585008408 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 871585008409 active site 871585008410 KMSKS motif; other site 871585008411 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 871585008412 tRNA binding surface [nucleotide binding]; other site 871585008413 anticodon binding site; other site 871585008414 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 871585008415 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 871585008416 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 871585008417 active site 871585008418 Riboflavin kinase; Region: Flavokinase; pfam01687 871585008419 Tellurite resistance protein and related permeases [Inorganic ion transport and metabolism]; Region: TehA; COG1275 871585008420 Tellurite-resistance/Dicarboxylate Transporter (TDT) family includes sulfite sensitivity protein (sulfite efflux pump; SSU1); Region: TDT_SSU1; cd09318 871585008421 gating phenylalanine in ion channel; other site 871585008422 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 871585008423 pyrimidine utilization regulatory protein R; Region: RutR; TIGR03613 871585008424 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 871585008425 YcdC-like protein, C-terminal region; Region: TetR_C_3; pfam08362 871585008426 aliphatic sulfonates transport ATP-binding subunit; Provisional; Region: ssuB; PRK11247 871585008427 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 871585008428 Walker A/P-loop; other site 871585008429 ATP binding site [chemical binding]; other site 871585008430 Q-loop/lid; other site 871585008431 ABC transporter signature motif; other site 871585008432 Walker B; other site 871585008433 D-loop; other site 871585008434 H-loop/switch region; other site 871585008435 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 871585008436 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 871585008437 putative PBP binding loops; other site 871585008438 dimer interface [polypeptide binding]; other site 871585008439 ABC-ATPase subunit interface; other site 871585008440 alkanesulfonate monooxygenase; Provisional; Region: PRK00719 871585008441 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 871585008442 active site 871585008443 dimer interface [polypeptide binding]; other site 871585008444 non-prolyl cis peptide bond; other site 871585008445 insertion regions; other site 871585008446 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 871585008447 substrate binding pocket [chemical binding]; other site 871585008448 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 871585008449 membrane-bound complex binding site; other site 871585008450 hinge residues; other site 871585008451 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 871585008452 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 871585008453 substrate binding pocket [chemical binding]; other site 871585008454 membrane-bound complex binding site; other site 871585008455 hinge residues; other site 871585008456 N-acetylglutamate synthase; Validated; Region: PRK05279 871585008457 AAK_NAGS-ABP: N-acetylglutamate (NAG) kinase-like domain of the NAG Synthase (NAGS) of the arginine-biosynthesis pathway (ABP) found in gamma- and beta-proteobacteria and higher plant chloroplasts. Domain architecture of these NAGS consisted of an...; Region: AAK_NAGS-ABP; cd04237 871585008458 putative nucleotide binding site [chemical binding]; other site 871585008459 putative substrate binding site [chemical binding]; other site 871585008460 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 871585008461 Coenzyme A binding pocket [chemical binding]; other site 871585008462 Domain of unknown function (DUF3315); Region: DUF3315; pfam11776 871585008463 Domain of unknown function (DUF3315); Region: DUF3315; pfam11776 871585008464 putative oxoacyl-(acyl carrier protein) reductase; Provisional; Region: PRK08945 871585008465 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 871585008466 NAD(P) binding site [chemical binding]; other site 871585008467 active site 871585008468 phosphoglycolate phosphatase; Provisional; Region: PRK13222 871585008469 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 871585008470 active site 871585008471 motif I; other site 871585008472 motif II; other site 871585008473 bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134 871585008474 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 871585008475 S-adenosylmethionine binding site [chemical binding]; other site 871585008476 DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019 871585008477 catalytic residues [active] 871585008478 hinge region; other site 871585008479 alpha helical domain; other site 871585008480 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 871585008481 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 871585008482 DNA-binding transcriptional repressor FabR; Provisional; Region: PRK11202 871585008483 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 871585008484 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_2; cd06216 871585008485 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 871585008486 FAD binding pocket [chemical binding]; other site 871585008487 FAD binding motif [chemical binding]; other site 871585008488 phosphate binding motif [ion binding]; other site 871585008489 beta-alpha-beta structure motif; other site 871585008490 NAD binding pocket [chemical binding]; other site 871585008491 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 871585008492 catalytic loop [active] 871585008493 iron binding site [ion binding]; other site 871585008494 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 871585008495 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 871585008496 putative di-iron ligands [ion binding]; other site 871585008497 ribonuclease PH; Reviewed; Region: rph; PRK00173 871585008498 Ribonuclease PH; Region: RNase_PH_bact; cd11362 871585008499 hexamer interface [polypeptide binding]; other site 871585008500 active site 871585008501 phospholipase C, phosphocholine-specific, Pseudomonas-type; Region: PC_PLC; TIGR03396 871585008502 Phosphoesterase family; Region: Phosphoesterase; pfam04185 871585008503 Domain of unknown function (DUF756); Region: DUF756; pfam05506 871585008504 Domain of unknown function (DUF756); Region: DUF756; pfam05506 871585008505 quinolinate phosphoribosyltransferase; Validated; Region: PRK09016 871585008506 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 871585008507 dimerization interface [polypeptide binding]; other site 871585008508 active site 871585008509 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 871585008510 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 871585008511 amidase catalytic site [active] 871585008512 Zn binding residues [ion binding]; other site 871585008513 substrate binding site [chemical binding]; other site 871585008514 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 871585008515 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 871585008516 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 871585008517 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 871585008518 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 871585008519 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 871585008520 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 871585008521 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 871585008522 tyrosine kinase; Provisional; Region: PRK11519 871585008523 Chain length determinant protein; Region: Wzz; pfam02706 871585008524 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 871585008525 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 871585008526 Low molecular weight phosphatase family; Region: LMWPc; cd00115 871585008527 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 871585008528 active site 871585008529 polysaccharide export protein Wza; Provisional; Region: PRK15078 871585008530 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 871585008531 Vi polysaccharide biosynthesis protein TviB; Provisional; Region: PRK15182 871585008532 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 871585008533 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 871585008534 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 871585008535 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 871585008536 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 871585008537 putative trimer interface [polypeptide binding]; other site 871585008538 Bacterial transferase hexapeptide (six repeats); Region: Hexapep; pfam00132 871585008539 putative CoA binding site [chemical binding]; other site 871585008540 WcxM-like, Left-handed parallel beta-Helix (LbH) N-terminal domain: This group is composed of Xanthomonas campestris WcxM and proteins with similarity to the WcxM N-terminal domain. WcxM is thought to be bifunctional, catalyzing both the isomerization...; Region: LbH_WxcM_N_like; cd03358 871585008541 putative trimer interface [polypeptide binding]; other site 871585008542 putative active site [active] 871585008543 putative substrate binding site [chemical binding]; other site 871585008544 putative CoA binding site [chemical binding]; other site 871585008545 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 871585008546 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 871585008547 inhibitor-cofactor binding pocket; inhibition site 871585008548 pyridoxal 5'-phosphate binding site [chemical binding]; other site 871585008549 catalytic residue [active] 871585008550 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 871585008551 trimer interface [polypeptide binding]; other site 871585008552 active site 871585008553 substrate binding site [chemical binding]; other site 871585008554 CoA binding site [chemical binding]; other site 871585008555 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 871585008556 This family is most closely related to the GT1 family of glycosyltransferases. wlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core; Region: GT1_wlbH_like; cd03798 871585008557 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 871585008558 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 871585008559 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 871585008560 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 871585008561 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 871585008562 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 871585008563 active site 871585008564 homodimer interface [polypeptide binding]; other site 871585008565 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 871585008566 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 871585008567 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 871585008568 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 871585008569 active site 871585008570 Bacterial sugar transferase; Region: Bac_transf; pfam02397 871585008571 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 871585008572 active site 871585008573 tetramer interface; other site 871585008574 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 871585008575 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 871585008576 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 871585008577 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 871585008578 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 871585008579 active site 871585008580 dimer interface [polypeptide binding]; other site 871585008581 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 871585008582 dimer interface [polypeptide binding]; other site 871585008583 active site 871585008584 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 871585008585 UDP-glucose 4-epimerase; Region: PLN02240 871585008586 NAD binding site [chemical binding]; other site 871585008587 homodimer interface [polypeptide binding]; other site 871585008588 active site 871585008589 substrate binding site [chemical binding]; other site 871585008590 Acyltransferase family; Region: Acyl_transf_3; pfam01757 871585008591 Sulfatase; Region: Sulfatase; pfam00884 871585008592 phosphomannomutase CpsG; Provisional; Region: PRK15414 871585008593 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 871585008594 active site 871585008595 substrate binding site [chemical binding]; other site 871585008596 metal binding site [ion binding]; metal-binding site 871585008597 L-lactate permease; Provisional; Region: PRK10420 871585008598 glycolate transporter; Provisional; Region: PRK09695 871585008599 DNA-binding transcriptional repressor LldR; Provisional; Region: PRK10421 871585008600 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 871585008601 DNA-binding site [nucleotide binding]; DNA binding site 871585008602 FCD domain; Region: FCD; pfam07729 871585008603 L-lactate dehydrogenase; Provisional; Region: lldD; PRK11197 871585008604 Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809 871585008605 active site 871585008606 substrate binding site [chemical binding]; other site 871585008607 FMN binding site [chemical binding]; other site 871585008608 putative catalytic residues [active] 871585008609 D-lactate dehydrogenase; Provisional; Region: PRK11183 871585008610 FAD binding domain; Region: FAD_binding_4; pfam01565 871585008611 D-lactate dehydrogenase, membrane binding; Region: Lact-deh-memb; pfam09330 871585008612 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 871585008613 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 871585008614 pyridoxal 5'-phosphate binding site [chemical binding]; other site 871585008615 homodimer interface [polypeptide binding]; other site 871585008616 catalytic residue [active] 871585008617 Transcriptional regulators [Transcription]; Region: GntR; COG1802 871585008618 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 871585008619 DNA-binding site [nucleotide binding]; DNA binding site 871585008620 FCD domain; Region: FCD; pfam07729 871585008621 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 871585008622 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 871585008623 tetramer interface [polypeptide binding]; other site 871585008624 active site 871585008625 Mg2+/Mn2+ binding site [ion binding]; other site 871585008626 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 871585008627 methylcitrate synthase; Provisional; Region: PRK12351 871585008628 oxalacetate binding site [chemical binding]; other site 871585008629 citrylCoA binding site [chemical binding]; other site 871585008630 coenzyme A binding site [chemical binding]; other site 871585008631 catalytic triad [active] 871585008632 2-methylisocitrate dehydratase, Fe/S-dependent; Region: 2met_isocit_dHY; TIGR02333 871585008633 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 871585008634 substrate binding site [chemical binding]; other site 871585008635 ligand binding site [chemical binding]; other site 871585008636 Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215 871585008637 substrate binding site [chemical binding]; other site 871585008638 AAA domain; Region: AAA_21; pfam13304 871585008639 Domain of unknown function (DUF4126); Region: DUF4126; pfam13548 871585008640 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 871585008641 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 871585008642 Coenzyme A binding pocket [chemical binding]; other site 871585008643 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 871585008644 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 871585008645 binding surface 871585008646 TPR motif; other site 871585008647 Sel1-like repeats; Region: SEL1; smart00671 871585008648 Uncharacterized protein conserved in bacteria [Function unknown]; Region: VgrG; COG3501 871585008649 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 871585008650 potential frameshift: common BLAST hit: gi|126640621|ref|YP_001083605.1| putative VGR-related protein 871585008651 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 871585008652 Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296 871585008653 Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296 871585008654 Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; pfam10106 871585008655 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 871585008656 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 871585008657 NAD(P) binding site [chemical binding]; other site 871585008658 active site 871585008659 Protein of unknown function (DUF2867); Region: DUF2867; pfam11066 871585008660 Predicted membrane protein [Function unknown]; Region: COG4420 871585008661 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 871585008662 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 871585008663 active site 871585008664 Protein of unknown function (DUF1260); Region: DUF1260; pfam06877 871585008665 SnoaL-like domain; Region: SnoaL_2; pfam12680 871585008666 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 871585008667 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 871585008668 N-terminal plug; other site 871585008669 ligand-binding site [chemical binding]; other site 871585008670 Predicted membrane protein [Function unknown]; Region: COG3503 871585008671 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 871585008672 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 871585008673 putative DNA binding site [nucleotide binding]; other site 871585008674 putative Zn2+ binding site [ion binding]; other site 871585008675 AsnC family; Region: AsnC_trans_reg; pfam01037 871585008676 D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711 871585008677 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 871585008678 mRNA stabilisation; Region: mRNA_stabil; pfam13929 871585008679 alanine racemase; Reviewed; Region: dadX; PRK03646 871585008680 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827 871585008681 active site 871585008682 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 871585008683 substrate binding site [chemical binding]; other site 871585008684 catalytic residues [active] 871585008685 dimer interface [polypeptide binding]; other site 871585008686 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150 871585008687 homotrimer interaction site [polypeptide binding]; other site 871585008688 putative active site [active] 871585008689 D-alanine/D-serine/glycine permease; Provisional; Region: PRK11049 871585008690 D-alanine/D-serine/glycine permease; Provisional; Region: PRK11049 871585008691 Transcriptional regulator [Transcription]; Region: LysR; COG0583 871585008692 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 871585008693 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 871585008694 dimerization interface [polypeptide binding]; other site 871585008695 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 871585008696 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 871585008697 tetrameric interface [polypeptide binding]; other site 871585008698 NAD binding site [chemical binding]; other site 871585008699 catalytic residues [active] 871585008700 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 871585008701 3-hydroxyisobutyrate dehydrogenase; Region: HIBADH; TIGR01692 871585008702 potential frameshift: common BLAST hit: gi|215485045|ref|YP_002327286.1| acetyl-coenzyme A synthetase 871585008703 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 871585008704 Domain of unknown function (DUF3448); Region: DUF3448; pfam11930 871585008705 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 871585008706 acyl-activating enzyme (AAE) consensus motif; other site 871585008707 active site 871585008708 AMP binding site [chemical binding]; other site 871585008709 CoA binding site [chemical binding]; other site 871585008710 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 871585008711 CoA binding site [chemical binding]; other site 871585008712 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 871585008713 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 871585008714 active site 871585008715 enoyl-CoA hydratase; Provisional; Region: PRK05862 871585008716 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 871585008717 substrate binding site [chemical binding]; other site 871585008718 oxyanion hole (OAH) forming residues; other site 871585008719 trimer interface [polypeptide binding]; other site 871585008720 RNA recognition motif (RRM) superfamily; Region: RRM_SF; cl17169 871585008721 3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617 871585008722 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 871585008723 substrate binding site [chemical binding]; other site 871585008724 oxyanion hole (OAH) forming residues; other site 871585008725 trimer interface [polypeptide binding]; other site 871585008726 2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766 871585008727 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 871585008728 metabolite-proton symporter; Region: 2A0106; TIGR00883 871585008729 putative substrate translocation pore; other site 871585008730 Autoinducer synthetase; Region: Autoind_synth; cl17404 871585008731 DNA-binding transcriptional activator SdiA; Provisional; Region: PRK10188 871585008732 Autoinducer binding domain; Region: Autoind_bind; pfam03472 871585008733 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 871585008734 DNA binding residues [nucleotide binding] 871585008735 dimerization interface [polypeptide binding]; other site 871585008736 acyl-CoA synthetase; Validated; Region: PRK05850 871585008737 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 871585008738 acyl-activating enzyme (AAE) consensus motif; other site 871585008739 active site 871585008740 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 871585008741 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 871585008742 active site 871585008743 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 871585008744 Condensation domain; Region: Condensation; pfam00668 871585008745 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 871585008746 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 871585008747 The adenylation domain of nonribosomal peptide synthetases (NRPS), including salinosporamide A polyketide synthase; Region: A_NRPS_Ta1_like; cd12116 871585008748 acyl-activating enzyme (AAE) consensus motif; other site 871585008749 AMP binding site [chemical binding]; other site 871585008750 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 871585008751 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 871585008752 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 871585008753 hydrophobic ligand binding site; other site 871585008754 Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033 871585008755 Protein of unknown function (DUF1329); Region: DUF1329; pfam07044 871585008756 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 871585008757 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 871585008758 NAD(P) binding site [chemical binding]; other site 871585008759 active site 871585008760 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 871585008761 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 871585008762 catalytic site [active] 871585008763 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 871585008764 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 871585008765 Stress-induced morphogen (activity unknown) [Signal transduction mechanisms]; Region: BolA; COG0271 871585008766 Invasion gene expression up-regulator, SirB; Region: SirB; cl01184 871585008767 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 871585008768 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 871585008769 P-loop; other site 871585008770 Magnesium ion binding site [ion binding]; other site 871585008771 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 871585008772 Magnesium ion binding site [ion binding]; other site 871585008773 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 871585008774 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 871585008775 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 871585008776 Predicted membrane protein [Function unknown]; Region: COG2259 871585008777 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399 871585008778 GMP synthase; Reviewed; Region: guaA; PRK00074 871585008779 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 871585008780 AMP/PPi binding site [chemical binding]; other site 871585008781 candidate oxyanion hole; other site 871585008782 catalytic triad [active] 871585008783 potential glutamine specificity residues [chemical binding]; other site 871585008784 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 871585008785 ATP Binding subdomain [chemical binding]; other site 871585008786 Ligand Binding sites [chemical binding]; other site 871585008787 Dimerization subdomain; other site 871585008788 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 871585008789 active site 871585008790 NTP binding site [chemical binding]; other site 871585008791 metal binding triad [ion binding]; metal-binding site 871585008792 antibiotic binding site [chemical binding]; other site 871585008793 Domain of unknown function (DUF4111); Region: DUF4111; pfam13427 871585008794 Predicted transcriptional regulators [Transcription]; Region: COG1695 871585008795 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 871585008796 Domain of Unknown Function with PDB structure (DUF3861); Region: DUF3861; pfam12977 871585008797 Pirin; Region: Pirin; pfam02678 871585008798 Pirin-related protein [General function prediction only]; Region: COG1741 871585008799 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 871585008800 OsmC-like protein; Region: OsmC; pfam02566 871585008801 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 871585008802 GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046 871585008803 putative C-terminal domain interface [polypeptide binding]; other site 871585008804 putative GSH binding site (G-site) [chemical binding]; other site 871585008805 putative dimer interface [polypeptide binding]; other site 871585008806 C-terminal, alpha helical domain of GTT1-like Glutathione S-transferases; Region: GST_C_GTT1_like; cd03189 871585008807 putative N-terminal domain interface [polypeptide binding]; other site 871585008808 putative dimer interface [polypeptide binding]; other site 871585008809 putative substrate binding pocket (H-site) [chemical binding]; other site 871585008810 Sporulation related domain; Region: SPOR; pfam05036 871585008811 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 871585008812 Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018 871585008813 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 871585008814 active site 871585008815 HIGH motif; other site 871585008816 nucleotide binding site [chemical binding]; other site 871585008817 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 871585008818 KMSK motif region; other site 871585008819 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 871585008820 tRNA binding surface [nucleotide binding]; other site 871585008821 anticodon binding site; other site 871585008822 malate dehydrogenase; Provisional; Region: PRK13529 871585008823 Malic enzyme, N-terminal domain; Region: malic; pfam00390 871585008824 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 871585008825 NAD(P) binding site [chemical binding]; other site 871585008826 Dyp-type peroxidase family; Region: Dyp_perox; cl01067 871585008827 LysE type translocator; Region: LysE; cl00565 871585008828 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 871585008829 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 871585008830 ABC-ATPase subunit interface; other site 871585008831 dimer interface [polypeptide binding]; other site 871585008832 putative PBP binding regions; other site 871585008833 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 871585008834 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 871585008835 Walker A/P-loop; other site 871585008836 ATP binding site [chemical binding]; other site 871585008837 Q-loop/lid; other site 871585008838 ABC transporter signature motif; other site 871585008839 Walker B; other site 871585008840 D-loop; other site 871585008841 H-loop/switch region; other site 871585008842 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 871585008843 metal binding site 2 [ion binding]; metal-binding site 871585008844 putative DNA binding helix; other site 871585008845 metal binding site 1 [ion binding]; metal-binding site 871585008846 dimer interface [polypeptide binding]; other site 871585008847 structural Zn2+ binding site [ion binding]; other site 871585008848 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 871585008849 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 871585008850 intersubunit interface [polypeptide binding]; other site 871585008851 ATP synthase I chain; Region: ATP_synt_I; cl09170 871585008852 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 871585008853 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 871585008854 F0F1 ATP synthase subunit C; Validated; Region: PRK06876 871585008855 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 871585008856 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 871585008857 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 871585008858 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 871585008859 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 871585008860 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 871585008861 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 871585008862 Walker A motif; other site 871585008863 ATP binding site [chemical binding]; other site 871585008864 Walker B motif; other site 871585008865 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 871585008866 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 871585008867 core domain interface [polypeptide binding]; other site 871585008868 delta subunit interface [polypeptide binding]; other site 871585008869 epsilon subunit interface [polypeptide binding]; other site 871585008870 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 871585008871 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 871585008872 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 871585008873 alpha subunit interaction interface [polypeptide binding]; other site 871585008874 Walker A motif; other site 871585008875 ATP binding site [chemical binding]; other site 871585008876 Walker B motif; other site 871585008877 inhibitor binding site; inhibition site 871585008878 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 871585008879 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 871585008880 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 871585008881 gamma subunit interface [polypeptide binding]; other site 871585008882 epsilon subunit interface [polypeptide binding]; other site 871585008883 LBP interface [polypeptide binding]; other site 871585008884 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 871585008885 catalytic residues [active] 871585008886 dimer interface [polypeptide binding]; other site 871585008887 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 871585008888 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 871585008889 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 871585008890 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 871585008891 putative substrate translocation pore; other site 871585008892 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 871585008893 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 871585008894 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 871585008895 EamA-like transporter family; Region: EamA; pfam00892 871585008896 EamA-like transporter family; Region: EamA; pfam00892 871585008897 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 871585008898 DNA protecting protein DprA; Region: dprA; TIGR00732 871585008899 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 871585008900 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 871585008901 Uncharacterized protein containing LysM domain [Function unknown]; Region: XkdP; COG1652 871585008902 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 871585008903 active site 871585008904 catalytic residues [active] 871585008905 metal binding site [ion binding]; metal-binding site 871585008906 TonB-dependent copper receptor; Region: TonB-copper; TIGR01778 871585008907 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 871585008908 N-terminal plug; other site 871585008909 ligand-binding site [chemical binding]; other site 871585008910 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; pfam09995 871585008911 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 871585008912 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 871585008913 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 871585008914 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 871585008915 dimer interface [polypeptide binding]; other site 871585008916 pyridoxal 5'-phosphate binding site [chemical binding]; other site 871585008917 catalytic residue [active] 871585008918 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 871585008919 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 871585008920 N-acetyl-D-glucosamine binding site [chemical binding]; other site 871585008921 catalytic residue [active] 871585008922 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 871585008923 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 871585008924 Protein of unknown function (DUF2938); Region: DUF2938; pfam11158 871585008925 Cu(I)-responsive transcriptional regulator; Region: CueR; TIGR02044 871585008926 Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg6; cd04781 871585008927 DNA binding residues [nucleotide binding] 871585008928 putative dimer interface [polypeptide binding]; other site 871585008929 putative metal binding residues [ion binding]; other site 871585008930 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4222 871585008931 hypothetical protein; Provisional; Region: PRK01254 871585008932 Radical SAM N-terminal; Region: Radical_SAM_N; pfam08497 871585008933 Radical SAM N-terminal; Region: Radical_SAM_N; pfam08497 871585008934 Domain of unknown function (DUF3362); Region: DUF3362; pfam11842 871585008935 Protein of unknown function (DUF2726); Region: DUF2726; pfam10881 871585008936 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150 871585008937 homotrimer interaction site [polypeptide binding]; other site 871585008938 putative active site [active] 871585008939 Inner membrane protein CreD; Region: CreD; cl01844 871585008940 sensory histidine kinase CreC; Provisional; Region: PRK11100 871585008941 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 871585008942 ATP binding site [chemical binding]; other site 871585008943 Mg2+ binding site [ion binding]; other site 871585008944 G-X-G motif; other site 871585008945 DNA-binding response regulator CreB; Provisional; Region: PRK11083 871585008946 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 871585008947 active site 871585008948 phosphorylation site [posttranslational modification] 871585008949 intermolecular recognition site; other site 871585008950 dimerization interface [polypeptide binding]; other site 871585008951 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 871585008952 DNA binding site [nucleotide binding] 871585008953 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 871585008954 active site 871585008955 DNA polymerase IV; Validated; Region: PRK02406 871585008956 DNA binding site [nucleotide binding] 871585008957 Uncharacterized bacterial muramidase containing a glycosyl hydrolase family 25 (GH25) catalytic domain. Endo-N-acetylmuramidases are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis...; Region: GH25_muramidase_1; cd06413 871585008958 active site 871585008959 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 871585008960 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 871585008961 putative transporter; Provisional; Region: PRK10504 871585008962 putative substrate translocation pore; other site 871585008963 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 871585008964 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 871585008965 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 871585008966 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 871585008967 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 871585008968 Transporter associated domain; Region: CorC_HlyC; smart01091 871585008969 hypothetical protein; Provisional; Region: PRK01752 871585008970 SEC-C motif; Region: SEC-C; pfam02810 871585008971 Predicted membrane protein [Function unknown]; Region: COG2860 871585008972 UPF0126 domain; Region: UPF0126; pfam03458 871585008973 UPF0126 domain; Region: UPF0126; pfam03458 871585008974 benzoate transport; Region: 2A0115; TIGR00895 871585008975 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 871585008976 putative substrate translocation pore; other site 871585008977 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 871585008978 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 871585008979 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 871585008980 CAP-like domain; other site 871585008981 active site 871585008982 primary dimer interface [polypeptide binding]; other site 871585008983 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 871585008984 Long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07059 871585008985 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 871585008986 acyl-activating enzyme (AAE) consensus motif; other site 871585008987 putative AMP binding site [chemical binding]; other site 871585008988 putative active site [active] 871585008989 putative CoA binding site [chemical binding]; other site 871585008990 Predicted membrane protein [Function unknown]; Region: COG3686 871585008991 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 871585008992 dimer interface [polypeptide binding]; other site 871585008993 substrate binding site [chemical binding]; other site 871585008994 metal binding sites [ion binding]; metal-binding site 871585008995 outer membrane porin, OprD family; Region: OprD; pfam03573 871585008996 Bacterial protein of unknown function (Gcw_chp); Region: Gcw_chp; cl09901 871585008997 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 871585008998 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 871585008999 inhibitor site; inhibition site 871585009000 active site 871585009001 dimer interface [polypeptide binding]; other site 871585009002 catalytic residue [active] 871585009003 class II aldolase/adducin domain protein; Provisional; Region: PRK07090 871585009004 intersubunit interface [polypeptide binding]; other site 871585009005 active site 871585009006 Zn2+ binding site [ion binding]; other site 871585009007 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 871585009008 DNA-binding site [nucleotide binding]; DNA binding site 871585009009 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 871585009010 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 871585009011 pyridoxal 5'-phosphate binding site [chemical binding]; other site 871585009012 homodimer interface [polypeptide binding]; other site 871585009013 catalytic residue [active] 871585009014 Predicted flavoprotein [General function prediction only]; Region: COG0431 871585009015 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 871585009016 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 871585009017 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 871585009018 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 871585009019 Walker A motif; other site 871585009020 ATP binding site [chemical binding]; other site 871585009021 Walker B motif; other site 871585009022 arginine finger; other site 871585009023 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 871585009024 Membrane fusogenic activity; Region: BMFP; pfam04380 871585009025 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 871585009026 Nitrogen regulatory protein P-II; Region: P-II; smart00938 871585009027 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 871585009028 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 871585009029 ATP cone domain; Region: ATP-cone; pfam03477 871585009030 bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase; Provisional; Region: ribD; PRK10786 871585009031 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 871585009032 catalytic motif [active] 871585009033 Zn binding site [ion binding]; other site 871585009034 RibD C-terminal domain; Region: RibD_C; cl17279 871585009035 Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG3392 871585009036 D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; cl17344 871585009037 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 871585009038 Lumazine binding domain; Region: Lum_binding; pfam00677 871585009039 Lumazine binding domain; Region: Lum_binding; pfam00677 871585009040 DNA polymerase III chi subunit, HolC; Region: DNA_pol3_chi; pfam04364 871585009041 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 871585009042 multifunctional aminopeptidase A; Provisional; Region: PRK00913 871585009043 interface (dimer of trimers) [polypeptide binding]; other site 871585009044 Substrate-binding/catalytic site; other site 871585009045 Zn-binding sites [ion binding]; other site 871585009046 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 871585009047 Predicted permeases [General function prediction only]; Region: COG0795; cl12074 871585009048 Predicted permeases [General function prediction only]; Region: COG0795; cl12074 871585009049 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 871585009050 phosphoglyceromutase; Provisional; Region: PRK05434 871585009051 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 871585009052 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 871585009053 C-terminal peptidase (prc); Region: prc; TIGR00225 871585009054 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cd00136 871585009055 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 871585009056 Catalytic dyad [active] 871585009057 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 871585009058 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 871585009059 active site 871585009060 phosphorylation site [posttranslational modification] 871585009061 intermolecular recognition site; other site 871585009062 dimerization interface [polypeptide binding]; other site 871585009063 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 871585009064 Walker A motif; other site 871585009065 ATP binding site [chemical binding]; other site 871585009066 Walker B motif; other site 871585009067 arginine finger; other site 871585009068 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 871585009069 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 871585009070 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 871585009071 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 871585009072 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 871585009073 dimer interface [polypeptide binding]; other site 871585009074 phosphorylation site [posttranslational modification] 871585009075 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 871585009076 ATP binding site [chemical binding]; other site 871585009077 Mg2+ binding site [ion binding]; other site 871585009078 G-X-G motif; other site 871585009079 response regulator; Provisional; Region: PRK09483 871585009080 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 871585009081 active site 871585009082 phosphorylation site [posttranslational modification] 871585009083 intermolecular recognition site; other site 871585009084 dimerization interface [polypeptide binding]; other site 871585009085 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 871585009086 DNA binding residues [nucleotide binding] 871585009087 dimerization interface [polypeptide binding]; other site 871585009088 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 871585009089 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 871585009090 threonine synthase; Reviewed; Region: PRK06721 871585009091 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 871585009092 homodimer interface [polypeptide binding]; other site 871585009093 pyridoxal 5'-phosphate binding site [chemical binding]; other site 871585009094 catalytic residue [active] 871585009095 homoserine dehydrogenase; Provisional; Region: PRK06349 871585009096 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 871585009097 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 871585009098 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 871585009099 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020 871585009100 dimerization domain [polypeptide binding]; other site 871585009101 dimer interface [polypeptide binding]; other site 871585009102 catalytic residues [active] 871585009103 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 871585009104 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 871585009105 active site 871585009106 Int/Topo IB signature motif; other site 871585009107 FeoA domain; Region: FeoA; pfam04023 871585009108 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 871585009109 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 871585009110 G1 box; other site 871585009111 GTP/Mg2+ binding site [chemical binding]; other site 871585009112 Switch I region; other site 871585009113 G2 box; other site 871585009114 G3 box; other site 871585009115 Switch II region; other site 871585009116 G4 box; other site 871585009117 G5 box; other site 871585009118 Nucleoside recognition; Region: Gate; pfam07670 871585009119 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 871585009120 Nucleoside recognition; Region: Gate; pfam07670 871585009121 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK03803 871585009122 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 871585009123 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 871585009124 cell division protein FtsW; Region: ftsW; TIGR02614 871585009125 glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710 871585009126 active site 871585009127 HIGH motif; other site 871585009128 nucleotide binding site [chemical binding]; other site 871585009129 active site 871585009130 KMSKS motif; other site 871585009131 RNA polymerase-binding protein DksA; Region: dksA; TIGR02420 871585009132 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 871585009133 hexamer interface [polypeptide binding]; other site 871585009134 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 871585009135 active site 871585009136 metal binding site [ion binding]; metal-binding site 871585009137 ADP-ribose pyrophosphatase NudF; Provisional; Region: nudF; PRK10729 871585009138 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 871585009139 dimer interface [polypeptide binding]; other site 871585009140 ADP-ribose binding site [chemical binding]; other site 871585009141 active site 871585009142 nudix motif; other site 871585009143 metal binding site [ion binding]; metal-binding site 871585009144 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 871585009145 ThiC-associated domain; Region: ThiC-associated; pfam13667 871585009146 Thiamine biosynthesis protein ThiC [Coenzyme metabolism]; Region: ThiC; COG0422 871585009147 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 871585009148 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 871585009149 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 871585009150 EamA-like transporter family; Region: EamA; pfam00892 871585009151 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 871585009152 transcriptional regulator PhoU; Provisional; Region: PRK11115 871585009153 PhoU domain; Region: PhoU; pfam01895 871585009154 PhoU domain; Region: PhoU; pfam01895 871585009155 oxidative damage protection protein; Provisional; Region: PRK05408 871585009156 argininosuccinate lyase; Provisional; Region: PRK00855 871585009157 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 871585009158 active sites [active] 871585009159 tetramer interface [polypeptide binding]; other site 871585009160 Histidine kinase; Region: His_kinase; pfam06580 871585009161 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 871585009162 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 871585009163 active site 871585009164 phosphorylation site [posttranslational modification] 871585009165 intermolecular recognition site; other site 871585009166 dimerization interface [polypeptide binding]; other site 871585009167 LytTr DNA-binding domain; Region: LytTR; smart00850 871585009168 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 871585009169 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 871585009170 domain interfaces; other site 871585009171 active site 871585009172 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 871585009173 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 871585009174 active site 871585009175 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 871585009176 active site 871585009177 H-NS histone family; Region: Histone_HNS; pfam00816 871585009178 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 871585009179 Type II secretion system (T2SS), protein N; Region: T2SN; pfam01203 871585009180 type II secretion system protein C; Region: typeII_sec_gspC; TIGR01713 871585009181 Type IV pilus biogenesis; Region: Pilus_PilP; pfam11356 871585009182 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 871585009183 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 871585009184 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 871585009185 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 871585009186 pilus (MSHA type) biogenesis protein MshL; Region: pilus_MshL; TIGR02519 871585009187 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 871585009188 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 871585009189 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 871585009190 phosphopeptide binding site; other site 871585009191 phosphoglycolate phosphatase; Provisional; Region: PRK13222 871585009192 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 871585009193 motif II; other site 871585009194 anthranilate synthase component I; Provisional; Region: PRK13565 871585009195 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 871585009196 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 871585009197 elongation factor Tu; Reviewed; Region: PRK00049 871585009198 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 871585009199 G1 box; other site 871585009200 GEF interaction site [polypeptide binding]; other site 871585009201 GTP/Mg2+ binding site [chemical binding]; other site 871585009202 Switch I region; other site 871585009203 G2 box; other site 871585009204 G3 box; other site 871585009205 Switch II region; other site 871585009206 G4 box; other site 871585009207 G5 box; other site 871585009208 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 871585009209 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 871585009210 Antibiotic Binding Site [chemical binding]; other site 871585009211 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK05740 871585009212 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 871585009213 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 871585009214 putative homodimer interface [polypeptide binding]; other site 871585009215 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 871585009216 heterodimer interface [polypeptide binding]; other site 871585009217 homodimer interface [polypeptide binding]; other site 871585009218 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 871585009219 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 871585009220 23S rRNA interface [nucleotide binding]; other site 871585009221 L7/L12 interface [polypeptide binding]; other site 871585009222 putative thiostrepton binding site; other site 871585009223 L25 interface [polypeptide binding]; other site 871585009224 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 871585009225 mRNA/rRNA interface [nucleotide binding]; other site 871585009226 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 871585009227 23S rRNA interface [nucleotide binding]; other site 871585009228 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 871585009229 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 871585009230 core dimer interface [polypeptide binding]; other site 871585009231 peripheral dimer interface [polypeptide binding]; other site 871585009232 L10 interface [polypeptide binding]; other site 871585009233 L11 interface [polypeptide binding]; other site 871585009234 putative EF-Tu interaction site [polypeptide binding]; other site 871585009235 putative EF-G interaction site [polypeptide binding]; other site 871585009236 potential frameshift: common BLAST hit: gi|215484890|ref|YP_002327129.1| DNA-directed RNA polymerase subunit beta 871585009237 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 871585009238 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 871585009239 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 871585009240 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 871585009241 RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562 871585009242 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 871585009243 RPB1 interaction site [polypeptide binding]; other site 871585009244 RPB11 interaction site [polypeptide binding]; other site 871585009245 RPB10 interaction site [polypeptide binding]; other site 871585009246 RPB3 interaction site [polypeptide binding]; other site 871585009247 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 871585009248 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 871585009249 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 871585009250 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 871585009251 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 871585009252 RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998 871585009253 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 871585009254 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 871585009255 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 871585009256 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 871585009257 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 871585009258 DNA binding site [nucleotide binding] 871585009259 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 871585009260 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 871585009261 active site 2 [active] 871585009262 active site 1 [active] 871585009263 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 871585009264 Predicted permease [General function prediction only]; Region: COG2056 871585009265 Na+-H+ antiporter family; Region: Na_H_antiport_2; pfam13726 871585009266 Outer membrane protein W [Cell envelope biogenesis, outer membrane]; Region: OmpW; COG3047 871585009267 Protein of unknown function (DUF1311); Region: DUF1311; pfam07007 871585009268 heat shock protein 90; Provisional; Region: PRK05218 871585009269 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 871585009270 ATP binding site [chemical binding]; other site 871585009271 Mg2+ binding site [ion binding]; other site 871585009272 G-X-G motif; other site 871585009273 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 871585009274 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 871585009275 catalytic residues [active] 871585009276 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 871585009277 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 871585009278 DNA binding residues [nucleotide binding] 871585009279 Predicted esterase of the alpha/beta hydrolase fold [General function prediction only]; Region: COG3545 871585009280 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 871585009281 Molecular chaperone, HSP90 family [Posttranslational modification, protein turnover, chaperones]; Region: HtpG; COG0326 871585009282 3-ketoacyl-CoA thiolase; Reviewed; Region: fadA; PRK08947 871585009283 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 871585009284 dimer interface [polypeptide binding]; other site 871585009285 active site 871585009286 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadB; PRK11730 871585009287 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 871585009288 substrate binding site [chemical binding]; other site 871585009289 oxyanion hole (OAH) forming residues; other site 871585009290 trimer interface [polypeptide binding]; other site 871585009291 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 871585009292 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 871585009293 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 871585009294 Aspartyl/asparaginyl beta-hydroxylase and related dioxygenases [Posttranslational modification, protein turnover, chaperones]; Region: COG3555 871585009295 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 871585009296 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 871585009297 GIY-YIG motif/motif A; other site 871585009298 active site 871585009299 catalytic site [active] 871585009300 putative DNA binding site [nucleotide binding]; other site 871585009301 metal binding site [ion binding]; metal-binding site 871585009302 UvrB/uvrC motif; Region: UVR; pfam02151 871585009303 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 871585009304 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 871585009305 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 871585009306 active site 871585009307 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II; cd00556 871585009308 active site 871585009309 dimer interface [polypeptide binding]; other site 871585009310 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 871585009311 Helix-turn-helix domain; Region: HTH_18; pfam12833 871585009312 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 871585009313 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 871585009314 DNA binding site [nucleotide binding] 871585009315 active site 871585009316 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_2; pfam13532 871585009317 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 871585009318 Transcriptional regulator [Transcription]; Region: IclR; COG1414 871585009319 Bacterial transcriptional regulator; Region: IclR; pfam01614 871585009320 Fusaric acid resistance protein family; Region: FUSC; pfam04632 871585009321 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 871585009322 Protein of unknown function (DUF1656); Region: DUF1656; pfam07869 871585009323 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 871585009324 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 871585009325 HlyD family secretion protein; Region: HlyD_3; pfam13437 871585009326 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 871585009327 Uncharacterized ACR, COG1678; Region: DUF179; pfam02622 871585009328 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 871585009329 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 871585009330 Walker A/P-loop; other site 871585009331 ATP binding site [chemical binding]; other site 871585009332 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 871585009333 ABC transporter signature motif; other site 871585009334 Walker B; other site 871585009335 D-loop; other site 871585009336 H-loop/switch region; other site 871585009337 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 871585009338 binding surface 871585009339 Tetratricopeptide repeat; Region: TPR_16; pfam13432 871585009340 TPR motif; other site 871585009341 Protein of unknown function (DUF1255); Region: DUF1255; pfam06865 871585009342 23S rRNA (guanosine-2'-O-)-methyltransferase; Provisional; Region: PRK11181 871585009343 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 871585009344 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 871585009345 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 871585009346 EamA-like transporter family; Region: EamA; pfam00892 871585009347 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 871585009348 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 871585009349 CoA-binding site [chemical binding]; other site 871585009350 ATP-binding [chemical binding]; other site 871585009351 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 871585009352 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 871585009353 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 871585009354 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 871585009355 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 871585009356 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 871585009357 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 871585009358 type IV-A pilus assembly ATPase PilB; Region: type_IV_pilB; TIGR02538 871585009359 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 871585009360 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 871585009361 Walker A motif; other site 871585009362 ATP binding site [chemical binding]; other site 871585009363 Walker B motif; other site 871585009364 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 871585009365 triosephosphate isomerase; Provisional; Region: PRK14567 871585009366 substrate binding site [chemical binding]; other site 871585009367 dimer interface [polypeptide binding]; other site 871585009368 catalytic triad [active] 871585009369 Preprotein translocase SecG subunit; Region: SecG; pfam03840 871585009370 Sm and related proteins; Region: Sm_like; cl00259 871585009371 ribosome maturation protein RimP; Reviewed; Region: PRK00092 871585009372 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 871585009373 putative oligomer interface [polypeptide binding]; other site 871585009374 putative RNA binding site [nucleotide binding]; other site 871585009375 transcription elongation factor NusA; Validated; Region: nusA; PRK09202 871585009376 NusA N-terminal domain; Region: NusA_N; pfam08529 871585009377 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 871585009378 RNA binding site [nucleotide binding]; other site 871585009379 homodimer interface [polypeptide binding]; other site 871585009380 NusA-like KH domain; Region: KH_5; pfam13184 871585009381 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 871585009382 G-X-X-G motif; other site 871585009383 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 871585009384 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 871585009385 translation initiation factor IF-2; Region: IF-2; TIGR00487 871585009386 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 871585009387 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 871585009388 G1 box; other site 871585009389 putative GEF interaction site [polypeptide binding]; other site 871585009390 GTP/Mg2+ binding site [chemical binding]; other site 871585009391 Switch I region; other site 871585009392 G2 box; other site 871585009393 G3 box; other site 871585009394 Switch II region; other site 871585009395 G4 box; other site 871585009396 G5 box; other site 871585009397 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 871585009398 Translation-initiation factor 2; Region: IF-2; pfam11987 871585009399 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 871585009400 ribosome-binding factor A; Provisional; Region: PRK13816 871585009401 putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12674 871585009402 Multiple resistance and pH regulation protein F (MrpF / PhaF); Region: MrpF_PhaF; cl09154 871585009403 putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK08965 871585009404 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12666 871585009405 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 871585009406 putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK09094 871585009407 putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12648 871585009408 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 871585009409 Domain of unknown function (DUF4040); Region: DUF4040; pfam13244 871585009410 Domain of unknown function (DUF4040); Region: DUF4040; cl00676 871585009411 Domain of unknown function (DUF4040); Region: DUF4040; cl00676 871585009412 potential frameshift: common BLAST hit: gi|299771774|ref|YP_003733800.1| ATP-binding protein 871585009413 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 871585009414 ABC transporter signature motif; other site 871585009415 Walker B; other site 871585009416 D-loop; other site 871585009417 H-loop/switch region; other site 871585009418 AAA domain; Region: AAA_23; pfam13476 871585009419 Family description; Region: UvrD_C_2; pfam13538 871585009420 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 871585009421 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 871585009422 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 871585009423 metal binding site [ion binding]; metal-binding site 871585009424 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_2; cd07253 871585009425 dimer interface [polypeptide binding]; other site 871585009426 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 871585009427 metal binding site [ion binding]; metal-binding site 871585009428 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 871585009429 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 871585009430 ABC1 family; Region: ABC1; cl17513 871585009431 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 871585009432 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3165 871585009433 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 871585009434 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 871585009435 S-adenosylmethionine binding site [chemical binding]; other site 871585009436 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4627 871585009437 Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971 871585009438 polyphosphate:AMP phosphotransferase; Region: poly_P_AMP_trns; TIGR03708 871585009439 Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971 871585009440 Uncharacterized protein/domain associated with GTPases [Function unknown]; Region: COG3597 871585009441 potential frameshift: common BLAST hit: gi|299771762|ref|YP_003733788.1| exonuclease V, gamma chain 871585009442 exonuclease V subunit gamma; Provisional; Region: recC; PRK11069 871585009443 Exodeoxyribonuclease V, gamma subunit; Region: Exonuc_V_gamma; pfam04257 871585009444 Part of AAA domain; Region: AAA_19; pfam13245 871585009445 ATP-dependent exoDNAse (exonuclease V) beta subunit (contains helicase and exonuclease domains) [DNA replication, recombination, and repair]; Region: RecB; COG1074 871585009446 Family description; Region: UvrD_C_2; pfam13538 871585009447 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 871585009448 AAA domain; Region: AAA_30; pfam13604 871585009449 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 871585009450 Family description; Region: UvrD_C_2; pfam13538 871585009451 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 871585009452 Beta-lactamase; Region: Beta-lactamase; pfam00144 871585009453 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 871585009454 16S/18S rRNA binding site [nucleotide binding]; other site 871585009455 S13e-L30e interaction site [polypeptide binding]; other site 871585009456 25S rRNA binding site [nucleotide binding]; other site 871585009457 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 871585009458 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 871585009459 RNase E interface [polypeptide binding]; other site 871585009460 trimer interface [polypeptide binding]; other site 871585009461 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 871585009462 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 871585009463 RNase E interface [polypeptide binding]; other site 871585009464 trimer interface [polypeptide binding]; other site 871585009465 active site 871585009466 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 871585009467 putative nucleic acid binding region [nucleotide binding]; other site 871585009468 G-X-X-G motif; other site 871585009469 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 871585009470 RNA binding site [nucleotide binding]; other site 871585009471 domain interface; other site 871585009472 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 871585009473 Thermotoga maritima CorA-like family; Region: TmCorA-like; cd12822 871585009474 oligomer interface [polypeptide binding]; other site 871585009475 metal binding site [ion binding]; metal-binding site 871585009476 metal binding site [ion binding]; metal-binding site 871585009477 putative Cl binding site [ion binding]; other site 871585009478 aspartate ring; other site 871585009479 basic sphincter; other site 871585009480 hydrophobic gate; other site 871585009481 periplasmic entrance; other site 871585009482 chaperone-modulator protein CbpM; Provisional; Region: PRK10265 871585009483 MerR HTH family regulatory protein; Region: MerR_2; pfam13591 871585009484 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 871585009485 chaperone protein DnaJ; Region: DnaJ_bact; TIGR02349 871585009486 HSP70 interaction site [polypeptide binding]; other site 871585009487 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 871585009488 substrate binding site [polypeptide binding]; other site 871585009489 dimer interface [polypeptide binding]; other site 871585009490 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 871585009491 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 871585009492 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 871585009493 dimerization interface [polypeptide binding]; other site 871585009494 domain crossover interface; other site 871585009495 redox-dependent activation switch; other site 871585009496 glutathione-regulated potassium-efflux system protein KefC; Provisional; Region: PRK03562 871585009497 transporter, monovalent cation:proton antiporter-2 (CPA2) family; Region: 2a37; TIGR00932 871585009498 TrkA-N domain; Region: TrkA_N; pfam02254 871585009499 primosome assembly protein PriA; Validated; Region: PRK05580 871585009500 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 871585009501 ATP binding site [chemical binding]; other site 871585009502 putative Mg++ binding site [ion binding]; other site 871585009503 helicase superfamily c-terminal domain; Region: HELICc; smart00490 871585009504 nucleotide binding region [chemical binding]; other site 871585009505 ATP-binding site [chemical binding]; other site 871585009506 type II secretion system protein F; Region: GspF; TIGR02120 871585009507 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 871585009508 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 871585009509 type II secretion system protein G; Region: typeII_sec_gspG; TIGR01710 871585009510 Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334 871585009511 tRNA-binding-domain-containing CsaA-like proteins. CsaA is a molecular chaperone with export related activities. CsaA has a putative tRNA binding activity. The functional unit of CsaA is a homodimer and this domain acts as a dimerization domain; Region: tRNA_bind_CsaA; cd02798 871585009512 dimer interface [polypeptide binding]; other site 871585009513 putative tRNA-binding site [nucleotide binding]; other site 871585009514 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 871585009515 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 871585009516 putative active site [active] 871585009517 catalytic triad [active] 871585009518 putative dimer interface [polypeptide binding]; other site 871585009519 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 871585009520 Transporter associated domain; Region: CorC_HlyC; smart01091 871585009521 SirA (also known as UvrY, and YhhP) belongs to a family of two-component response regulators that controls secondary metabolism and virulence. The other member of this two-component system is a sensor kinase called BarA which phosphorylates SirA. A...; Region: SirA; cd03423 871585009522 CPxP motif; other site 871585009523 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 871585009524 hydroxyglutarate oxidase; Provisional; Region: PRK11728 871585009525 Electron transfer flavoprotein-ubiquinone oxidoreductase; Region: ETF_QO; pfam05187 871585009526 Ferredoxin-like protein [Energy production and conversion]; Region: FixX; COG2440 871585009527 Protein of unknown function (DUF1285); Region: DUF1285; pfam06938 871585009528 glutamate racemase; Provisional; Region: PRK00865 871585009529 aspartate racemase; Region: asp_race; TIGR00035 871585009530 Domain of unknown function (DUF4062); Region: DUF4062; pfam13271 871585009531 ferrochelatase; Reviewed; Region: hemH; PRK00035 871585009532 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 871585009533 C-terminal domain interface [polypeptide binding]; other site 871585009534 active site 871585009535 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 871585009536 active site 871585009537 N-terminal domain interface [polypeptide binding]; other site 871585009538 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 871585009539 Domain of unknown function (DUF329); Region: DUF329; pfam03884 871585009540 Putative methyltransferase; Region: Methyltransf_4; cl17290 871585009541 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 871585009542 uncharacterized flavoprotein, PP_4765 family; Region: flavo_PP4765; TIGR03862 871585009543 Glutathione-dependent formaldehyde-activating enzyme; Region: GFA; pfam04828 871585009544 chromosome condensation membrane protein; Provisional; Region: PRK14196 871585009545 HopJ type III effector protein; Region: HopJ; pfam08888 871585009546 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 871585009547 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 871585009548 ABC1 family; Region: ABC1; cl17513 871585009549 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 871585009550 Dibenzothiophene (DBT) desulfurization enzyme C; Region: DszC; cd01163 871585009551 Flavin binding site [chemical binding]; other site 871585009552 Dibenzothiophene (DBT) desulfurization enzyme C; Region: DszC; cd01163 871585009553 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 871585009554 Flavin binding site [chemical binding]; other site 871585009555 multidrug efflux protein; Reviewed; Region: PRK01766 871585009556 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 871585009557 cation binding site [ion binding]; other site 871585009558 Protein of unknown function, DUF606; Region: DUF606; pfam04657 871585009559 HemN family oxidoreductase; Provisional; Region: PRK05660 871585009560 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 871585009561 FeS/SAM binding site; other site 871585009562 HemN C-terminal domain; Region: HemN_C; pfam06969 871585009563 short chain dehydrogenase; Provisional; Region: PRK12744 871585009564 tetrahydroxynaphthalene/trihydroxynaphthalene reductase-like, classical (c) SDRs; Region: THN_reductase-like_SDR_c; cd05362 871585009565 NADP binding site [chemical binding]; other site 871585009566 homodimer interface [polypeptide binding]; other site 871585009567 active site 871585009568 substrate binding site [chemical binding]; other site 871585009569 Transcriptional regulator [Transcription]; Region: LysR; COG0583 871585009570 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 871585009571 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 871585009572 putative effector binding pocket; other site 871585009573 putative dimerization interface [polypeptide binding]; other site 871585009574 long-chain-acyl-CoA synthetase; Validated; Region: PRK08279 871585009575 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 871585009576 Fatty acid transport proteins (FATP) play dual roles as fatty acid transporters and its activation enzymes; Region: FATP_FACS; cd05940 871585009577 acyl-activating enzyme (AAE) consensus motif; other site 871585009578 putative AMP binding site [chemical binding]; other site 871585009579 putative active site [active] 871585009580 putative CoA binding site [chemical binding]; other site 871585009581 Ribonucleases G and E [Translation, ribosomal structure and biogenesis]; Region: CafA; COG1530 871585009582 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 871585009583 homodimer interface [polypeptide binding]; other site 871585009584 oligonucleotide binding site [chemical binding]; other site 871585009585 potential frameshift: common BLAST hit: gi|169634491|ref|YP_001708227.1| 23S rRNA pseudouridylate synthase 871585009586 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 871585009587 RNA binding surface [nucleotide binding]; other site 871585009588 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 871585009589 active site 871585009590 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 871585009591 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 871585009592 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 871585009593 motif II; other site 871585009594 Predicted transcriptional regulator [Transcription]; Region: COG2378 871585009595 HTH domain; Region: HTH_11; pfam08279 871585009596 WYL domain; Region: WYL; pfam13280 871585009597 GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972 871585009598 GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046 871585009599 putative C-terminal domain interface [polypeptide binding]; other site 871585009600 putative GSH binding site (G-site) [chemical binding]; other site 871585009601 putative dimer interface [polypeptide binding]; other site 871585009602 C-terminal, alpha helical domain of an unknown subfamily 8 of Glutathione S-transferases; Region: GST_C_8; cd03207 871585009603 dimer interface [polypeptide binding]; other site 871585009604 N-terminal domain interface [polypeptide binding]; other site 871585009605 putative substrate binding pocket (H-site) [chemical binding]; other site 871585009606 Protein of unknown function (DUF1345); Region: DUF1345; pfam07077 871585009607 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 871585009608 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 871585009609 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 871585009610 dimerization interface [polypeptide binding]; other site 871585009611 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 871585009612 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 871585009613 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 871585009614 Heme-dependent peroxidases similar to plant peroxidases; Region: plant_peroxidase_like; cl00196 871585009615 heme binding site [chemical binding]; other site 871585009616 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 871585009617 Signal transduction protein containing GAF and PtsI domains [Signal transduction mechanisms]; Region: PtsP; COG3605 871585009618 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 871585009619 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 871585009620 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 871585009621 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 871585009622 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671 871585009623 putative active site [active] 871585009624 Ap4A binding site [chemical binding]; other site 871585009625 nudix motif; other site 871585009626 putative metal binding site [ion binding]; other site 871585009627 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 871585009628 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 871585009629 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4320 871585009630 Uncharacterized protein conserved in bacteria (DUF2252); Region: DUF2252; pfam10009 871585009631 Sporulation control protein [General function prediction only]; Region: Spo0M; COG4326 871585009632 SpoOM protein; Region: Spo0M; pfam07070 871585009633 Transcriptional regulator [Transcription]; Region: LysR; COG0583 871585009634 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 871585009635 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 871585009636 dimerization interface [polypeptide binding]; other site 871585009637 Predicted membrane protein (DUF2061); Region: DUF2061; pfam09834 871585009638 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 871585009639 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 871585009640 substrate binding site [chemical binding]; other site 871585009641 ligand binding site [chemical binding]; other site 871585009642 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 871585009643 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 871585009644 substrate binding site [chemical binding]; other site 871585009645 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 871585009646 tartrate dehydrogenase; Region: TTC; TIGR02089 871585009647 Protein of unknown function (DUF1311); Region: DUF1311; cl01530 871585009648 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 871585009649 rRNA binding site [nucleotide binding]; other site 871585009650 predicted 30S ribosome binding site; other site 871585009651 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 871585009652 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 871585009653 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 871585009654 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 871585009655 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 871585009656 dimerization interface 3.5A [polypeptide binding]; other site 871585009657 active site 871585009658 Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963 871585009659 active site 871585009660 homodimer interface [polypeptide binding]; other site 871585009661 FimV N-terminal domain; Region: FimV_core; TIGR03505 871585009662 aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK06598 871585009663 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 871585009664 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 871585009665 putative catalytic site [active] 871585009666 putative metal binding site [ion binding]; other site 871585009667 putative phosphate binding site [ion binding]; other site 871585009668 glutamate/aspartate:proton symporter; Provisional; Region: gltP; PRK11283 871585009669 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 871585009670 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 871585009671 This family is most closely related to the GT1 family of glycosyltransferases. WavL in Vibrio cholerae has been shown to be involved in the biosynthesis of the lipopolysaccharide core; Region: GT1_WavL_like; cd03819 871585009672 putative ADP-binding pocket [chemical binding]; other site 871585009673 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 871585009674 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 871585009675 putative acyl-acceptor binding pocket; other site 871585009676 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 871585009677 ABC transporter ATPase component; Reviewed; Region: PRK11147 871585009678 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 871585009679 Walker A/P-loop; other site 871585009680 ATP binding site [chemical binding]; other site 871585009681 ABC transporter signature motif; other site 871585009682 Walker B; other site 871585009683 D-loop; other site 871585009684 H-loop/switch region; other site 871585009685 ABC transporter; Region: ABC_tran_2; pfam12848 871585009686 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 871585009687 SlyX; Region: SlyX; pfam04102 871585009688 Arginate lyase and other MDR family members; Region: AL_MDR; cd08252 871585009689 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817 871585009690 putative NAD(P) binding site [chemical binding]; other site 871585009691 dimer interface [polypeptide binding]; other site 871585009692 Predicted transcriptional regulators [Transcription]; Region: COG1733 871585009693 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 871585009694 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 871585009695 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 871585009696 active site 871585009697 interdomain interaction site; other site 871585009698 putative metal-binding site [ion binding]; other site 871585009699 nucleotide binding site [chemical binding]; other site 871585009700 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 871585009701 domain I; other site 871585009702 DNA binding groove [nucleotide binding] 871585009703 phosphate binding site [ion binding]; other site 871585009704 domain II; other site 871585009705 domain III; other site 871585009706 nucleotide binding site [chemical binding]; other site 871585009707 catalytic site [active] 871585009708 domain IV; other site 871585009709 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 871585009710 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 871585009711 Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272 871585009712 Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272 871585009713 Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247 871585009714 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 871585009715 Part of AAA domain; Region: AAA_19; pfam13245 871585009716 Family description; Region: UvrD_C_2; pfam13538 871585009717 RNA-binding proteins (RRM domain) [General function prediction only]; Region: COG0724 871585009718 RNA recognition motif; Region: RRM; smart00360 871585009719 ASCH domain; Region: ASCH; pfam04266 871585009720 putative cation:proton antiport protein; Provisional; Region: PRK10669 871585009721 Kef-type K+ transport system, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: RosB; COG4651 871585009722 TrkA-N domain; Region: TrkA_N; pfam02254 871585009723 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 871585009724 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 871585009725 Coniferyl aldehyde dehydrogenase-like; Region: ALDH_CALDH_CalB; cd07133 871585009726 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 871585009727 NAD(P) binding site [chemical binding]; other site 871585009728 catalytic residues [active] 871585009729 Bacterial transcriptional repressor; Region: TetR; pfam13972 871585009730 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 871585009731 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 871585009732 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 871585009733 putative active site [active] 871585009734 putative substrate binding site [chemical binding]; other site 871585009735 putative cosubstrate binding site; other site 871585009736 catalytic site [active] 871585009737 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 871585009738 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 871585009739 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 871585009740 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 871585009741 methionine sulfoxide reductase A; Provisional; Region: PRK14054 871585009742 Domain of unknown function (DUF4105); Region: DUF4105; pfam13387 871585009743 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 871585009744 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 871585009745 folate binding site [chemical binding]; other site 871585009746 NADP+ binding site [chemical binding]; other site 871585009747 thymidylate synthase; Reviewed; Region: thyA; PRK01827 871585009748 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 871585009749 dimerization interface [polypeptide binding]; other site 871585009750 active site 871585009751 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK12437 871585009752 NRDE protein; Region: NRDE; cl01315 871585009753 Predicted phosphatase [General function prediction only]; Region: PhoX; COG3211 871585009754 Bacterial protein of unknown function (DUF839); Region: DUF839; pfam05787 871585009755 Sec-independent protein translocase protein (TatC); Region: TatC; cl00521 871585009756 twin arginine translocase protein A; Provisional; Region: tatA; PRK00191 871585009757 twin arginine-targeting protein translocase TatB; Region: tatB; TIGR01410 871585009758 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 871585009759 Membrane transport protein; Region: Mem_trans; cl09117 871585009760 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 871585009761 active site 871585009762 dimerization interface [polypeptide binding]; other site 871585009763 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 871585009764 Sel1-like repeats; Region: SEL1; smart00671 871585009765 Sel1-like repeats; Region: SEL1; smart00671 871585009766 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 871585009767 S-adenosylmethionine binding site [chemical binding]; other site 871585009768 homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175 871585009769 homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392 871585009770 2-isopropylmalate synthase; Validated; Region: PRK03739 871585009771 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 871585009772 active site 871585009773 catalytic residues [active] 871585009774 metal binding site [ion binding]; metal-binding site 871585009775 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 871585009776 Fe(II)-dependent oxygenase superfamily protein; Provisional; Region: PRK05467 871585009777 Outer membrane receptor for monomeric catechols [Inorganic ion transport and metabolism]; Region: Fiu; COG4774 871585009778 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 871585009779 N-terminal plug; other site 871585009780 ligand-binding site [chemical binding]; other site 871585009781 trigger factor; Provisional; Region: tig; PRK01490 871585009782 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 871585009783 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 871585009784 Clp protease; Region: CLP_protease; pfam00574 871585009785 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 871585009786 oligomer interface [polypeptide binding]; other site 871585009787 active site residues [active] 871585009788 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 871585009789 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 871585009790 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 871585009791 Walker A motif; other site 871585009792 ATP binding site [chemical binding]; other site 871585009793 Walker B motif; other site 871585009794 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 871585009795 Protein of unknown function (DUF2846); Region: DUF2846; pfam11008 871585009796 Uncharacterized protein conserved in bacteria (DUF2059); Region: DUF2059; pfam09832 871585009797 Fumarate hydratase (Fumerase); Region: Fumerase; pfam05681 871585009798 Fumarase C-terminus; Region: Fumerase_C; pfam05683 871585009799 phosphate acetyltransferase; Reviewed; Region: PRK05632 871585009800 DRTGG domain; Region: DRTGG; pfam07085 871585009801 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 871585009802 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 871585009803 propionate/acetate kinase; Provisional; Region: PRK12379 871585009804 phosphogluconate dehydratase; Validated; Region: PRK09054 871585009805 6-phosphogluconate dehydratase; Region: edd; TIGR01196 871585009806 keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718 871585009807 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 871585009808 active site 871585009809 intersubunit interface [polypeptide binding]; other site 871585009810 catalytic residue [active] 871585009811 GntP family permease; Region: GntP_permease; pfam02447 871585009812 fructuronate transporter; Provisional; Region: PRK10034; cl15264 871585009813 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 871585009814 ATP-binding site [chemical binding]; other site 871585009815 Gluconate-6-phosphate binding site [chemical binding]; other site 871585009816 Shikimate kinase; Region: SKI; pfam01202 871585009817 NADP+-dependent non-phosphorylating glyceraldehyde 3-phosphate dehydrogenase and ALDH family 11; Region: ALDH_F11_NP-GAPDH; cd07082 871585009818 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 871585009819 tetrameric interface [polypeptide binding]; other site 871585009820 activator binding site; other site 871585009821 NADP binding site [chemical binding]; other site 871585009822 substrate binding site [chemical binding]; other site 871585009823 catalytic residues [active] 871585009824 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 871585009825 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 871585009826 putative catalytic cysteine [active] 871585009827 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 871585009828 Leucine carboxyl methyltransferase; Region: LCM; pfam04072 871585009829 beta-hexosaminidase; Provisional; Region: PRK05337 871585009830 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 871585009831 carboxy-terminal protease; Provisional; Region: PRK11186 871585009832 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 871585009833 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 871585009834 protein binding site [polypeptide binding]; other site 871585009835 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 871585009836 Catalytic dyad [active] 871585009837 C-terminal domain of tail specific protease (DUF3340); Region: DUF3340; pfam11818 871585009838 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 871585009839 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 871585009840 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 871585009841 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 871585009842 active site 871585009843 Iron-sulphur cluster assembly; Region: Fe-S_assembly; pfam04384 871585009844 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 871585009845 active site 871585009846 multimer interface [polypeptide binding]; other site 871585009847 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK11194 871585009848 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 871585009849 FeS/SAM binding site; other site 871585009850 type IV pilus biogenesis/stability protein PilW; Region: type_IV_pilW; TIGR02521 871585009851 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 871585009852 binding surface 871585009853 TPR motif; other site 871585009854 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 871585009855 TPR motif; other site 871585009856 binding surface 871585009857 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 871585009858 binding surface 871585009859 TPR motif; other site 871585009860 Helix-turn-helix domain; Region: HTH_25; pfam13413 871585009861 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 871585009862 potential frameshift: common BLAST hit: gi|215484684|ref|YP_002326919.1| 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase 871585009863 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 871585009864 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 871585009865 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 871585009866 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 871585009867 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 871585009868 dimer interface [polypeptide binding]; other site 871585009869 motif 1; other site 871585009870 active site 871585009871 motif 2; other site 871585009872 motif 3; other site 871585009873 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 871585009874 anticodon binding site; other site 871585009875 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2976 871585009876 Uncharacterized protein conserved in bacteria (DUF2133); Region: DUF2133; pfam09976 871585009877 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 871585009878 TPR motif; other site 871585009879 binding surface 871585009880 outer membrane assembly lipoprotein YfgL; Region: assembly_YfgL; TIGR03300 871585009881 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 871585009882 Trp docking motif [polypeptide binding]; other site 871585009883 active site 871585009884 GTP-binding protein Der; Reviewed; Region: PRK00093 871585009885 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 871585009886 G1 box; other site 871585009887 GTP/Mg2+ binding site [chemical binding]; other site 871585009888 Switch I region; other site 871585009889 G2 box; other site 871585009890 Switch II region; other site 871585009891 G3 box; other site 871585009892 G4 box; other site 871585009893 G5 box; other site 871585009894 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 871585009895 G1 box; other site 871585009896 GTP/Mg2+ binding site [chemical binding]; other site 871585009897 Switch I region; other site 871585009898 G2 box; other site 871585009899 G3 box; other site 871585009900 Switch II region; other site 871585009901 G4 box; other site 871585009902 G5 box; other site 871585009903 Beta-ketoacyl synthase, N-terminal domain; Region: Ketoacyl-synt_2; pfam13723 871585009904 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 871585009905 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 871585009906 putative acyl-acceptor binding pocket; other site 871585009907 Phosphopantetheine attachment site; Region: PP-binding; cl09936 871585009908 acyl carrier protein; Provisional; Region: PRK05350 871585009909 Predicted membrane protein [Function unknown]; Region: COG4648 871585009910 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 871585009911 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 871585009912 acyl-activating enzyme (AAE) consensus motif; other site 871585009913 active site 871585009914 AMP binding site [chemical binding]; other site 871585009915 CoA binding site [chemical binding]; other site 871585009916 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 871585009917 active site 2 [active] 871585009918 active site 1 [active] 871585009919 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 871585009920 Ligand binding site; other site 871585009921 Putative Catalytic site; other site 871585009922 DXD motif; other site 871585009923 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 871585009924 putative acyl-acceptor binding pocket; other site 871585009925 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 871585009926 active sites [active] 871585009927 tetramer interface [polypeptide binding]; other site 871585009928 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 871585009929 active site 871585009930 Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl17548 871585009931 Predicted exporter [General function prediction only]; Region: COG4258 871585009932 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 871585009933 3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK09185 871585009934 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 871585009935 dimer interface [polypeptide binding]; other site 871585009936 active site 871585009937 Domain of unknown function, appears to be related to a diverse group of beta-hydroxydecanoyl ACP dehydratases (FabA) and beta-hydroxyacyl ACP dehydratases (FabZ). This group appears to lack the conserved active site histidine of FabA and FabZ; Region: FabA_like; cd01289 871585009938 putative active site 1 [active] 871585009939 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 871585009940 3-oxoacyl-(acyl-carrier-protein) reductase, putative; Region: fabG_rel; TIGR01831 871585009941 NAD(P) binding site [chemical binding]; other site 871585009942 homotetramer interface [polypeptide binding]; other site 871585009943 homodimer interface [polypeptide binding]; other site 871585009944 active site 871585009945 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK09116 871585009946 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 871585009947 dimer interface [polypeptide binding]; other site 871585009948 active site 871585009949 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 871585009950 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 871585009951 preprotein translocase subunit SecB; Validated; Region: PRK05751 871585009952 SecA binding site; other site 871585009953 Preprotein binding site; other site 871585009954 Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418 871585009955 GSH binding site [chemical binding]; other site 871585009956 catalytic residues [active] 871585009957 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 871585009958 active site residue [active] 871585009959 GTPase RsgA; Reviewed; Region: PRK12288 871585009960 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 871585009961 RNA binding site [nucleotide binding]; other site 871585009962 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 871585009963 GTPase/Zn-binding domain interface [polypeptide binding]; other site 871585009964 GTP/Mg2+ binding site [chemical binding]; other site 871585009965 G4 box; other site 871585009966 G5 box; other site 871585009967 G1 box; other site 871585009968 Switch I region; other site 871585009969 G2 box; other site 871585009970 G3 box; other site 871585009971 Switch II region; other site 871585009972 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 871585009973 catalytic site [active] 871585009974 putative active site [active] 871585009975 putative substrate binding site [chemical binding]; other site 871585009976 dimer interface [polypeptide binding]; other site 871585009977 Bax inhibitor 1 like; Region: BaxI_1; cl17691 871585009978 Enoyl-[acyl-carrier-protein]; Region: FabI; COG0623 871585009979 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 871585009980 NAD binding site [chemical binding]; other site 871585009981 homotetramer interface [polypeptide binding]; other site 871585009982 homodimer interface [polypeptide binding]; other site 871585009983 substrate binding site [chemical binding]; other site 871585009984 active site 871585009985 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 871585009986 macrolide transporter ATP-binding /permease protein; Provisional; Region: PRK10535 871585009987 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 871585009988 Walker A/P-loop; other site 871585009989 ATP binding site [chemical binding]; other site 871585009990 Q-loop/lid; other site 871585009991 ABC transporter signature motif; other site 871585009992 Walker B; other site 871585009993 D-loop; other site 871585009994 H-loop/switch region; other site 871585009995 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 871585009996 FtsX-like permease family; Region: FtsX; pfam02687 871585009997 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 871585009998 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 871585009999 HlyD family secretion protein; Region: HlyD_3; pfam13437 871585010000 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 871585010001 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 871585010002 Lipopolysaccharide-assembly; Region: LptE; pfam04390 871585010003 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 871585010004 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 871585010005 HIGH motif; other site 871585010006 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 871585010007 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 871585010008 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 871585010009 active site 871585010010 KMSKS motif; other site 871585010011 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 871585010012 tRNA binding surface [nucleotide binding]; other site 871585010013 acetolactate synthase 3 catalytic subunit; Validated; Region: PRK06466 871585010014 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 871585010015 PYR/PP interface [polypeptide binding]; other site 871585010016 dimer interface [polypeptide binding]; other site 871585010017 TPP binding site [chemical binding]; other site 871585010018 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 871585010019 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 871585010020 TPP-binding site [chemical binding]; other site 871585010021 dimer interface [polypeptide binding]; other site 871585010022 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 871585010023 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 871585010024 putative valine binding site [chemical binding]; other site 871585010025 dimer interface [polypeptide binding]; other site 871585010026 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 871585010027 ketol-acid reductoisomerase; Provisional; Region: PRK05479 871585010028 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 871585010029 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 871585010030 MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300 871585010031 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 871585010032 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 871585010033 metal binding site [ion binding]; metal-binding site 871585010034 active site 871585010035 I-site; other site 871585010036 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 871585010037 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 871585010038 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 871585010039 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 871585010040 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 871585010041 G1 box; other site 871585010042 putative GEF interaction site [polypeptide binding]; other site 871585010043 GTP/Mg2+ binding site [chemical binding]; other site 871585010044 Switch I region; other site 871585010045 G2 box; other site 871585010046 G3 box; other site 871585010047 Switch II region; other site 871585010048 G4 box; other site 871585010049 G5 box; other site 871585010050 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 871585010051 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 871585010052 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 871585010053 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 871585010054 active site 871585010055 aconitate hydratase; Validated; Region: PRK09277 871585010056 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 871585010057 substrate binding site [chemical binding]; other site 871585010058 ligand binding site [chemical binding]; other site 871585010059 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 871585010060 substrate binding site [chemical binding]; other site 871585010061 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179 871585010062 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 871585010063 putative ATP binding site [chemical binding]; other site 871585010064 putative substrate interface [chemical binding]; other site 871585010065 Transcriptional regulator [Transcription]; Region: LysR; COG0583 871585010066 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 871585010067 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 871585010068 dimerization interface [polypeptide binding]; other site 871585010069 substrate binding pocket [chemical binding]; other site 871585010070 tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815 871585010071 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 871585010072 FMN binding site [chemical binding]; other site 871585010073 active site 871585010074 catalytic residues [active] 871585010075 substrate binding site [chemical binding]; other site 871585010076 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 871585010077 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 871585010078 putative substrate translocation pore; other site 871585010079 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 871585010080 homotrimer interaction site [polypeptide binding]; other site 871585010081 putative active site [active] 871585010082 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 871585010083 EamA-like transporter family; Region: EamA; pfam00892 871585010084 EamA-like transporter family; Region: EamA; pfam00892 871585010085 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 871585010086 NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288 871585010087 ligand binding site [chemical binding]; other site 871585010088 homodimer interface [polypeptide binding]; other site 871585010089 NAD(P) binding site [chemical binding]; other site 871585010090 trimer interface B [polypeptide binding]; other site 871585010091 trimer interface A [polypeptide binding]; other site 871585010092 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 871585010093 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 871585010094 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; COG1282 871585010095 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 871585010096 acetoacetyl-CoA reductase; Provisional; Region: PRK12935 871585010097 putative NAD(P) binding site [chemical binding]; other site 871585010098 active site 871585010099 iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090 871585010100 hydroxypyruvate isomerase; Region: OH-pyruv-isom; TIGR03234 871585010101 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 871585010102 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 871585010103 enoyl-CoA hydratase; Provisional; Region: PRK07509 871585010104 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 871585010105 substrate binding site [chemical binding]; other site 871585010106 oxyanion hole (OAH) forming residues; other site 871585010107 trimer interface [polypeptide binding]; other site 871585010108 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 871585010109 dimer interface [polypeptide binding]; other site 871585010110 phosphorylation site [posttranslational modification] 871585010111 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 871585010112 ATP binding site [chemical binding]; other site 871585010113 Mg2+ binding site [ion binding]; other site 871585010114 G-X-G motif; other site 871585010115 Response regulator receiver domain; Region: Response_reg; pfam00072 871585010116 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 871585010117 active site 871585010118 phosphorylation site [posttranslational modification] 871585010119 intermolecular recognition site; other site 871585010120 dimerization interface [polypeptide binding]; other site 871585010121 FOG: HPt domain [Signal transduction mechanisms]; Region: ArcB; COG2198 871585010122 putative binding surface; other site 871585010123 active site 871585010124 cysteine synthase B; Region: cysM; TIGR01138 871585010125 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 871585010126 dimer interface [polypeptide binding]; other site 871585010127 pyridoxal 5'-phosphate binding site [chemical binding]; other site 871585010128 catalytic residue [active] 871585010129 Uncharacterized bacterial subgroup of the DEDDy 3'-5' exonuclease domain of family-B DNA polymerases; Region: DNA_polB_like1_exo; cd05782 871585010130 active site 871585010131 catalytic site [active] 871585010132 substrate binding site [chemical binding]; other site 871585010133 Predicted 3'-5' exonuclease related to the exonuclease domain of PolB; Region: DNA_pol_B_exo2; pfam10108 871585010134 23S rRNA m(5)U1939 methyltransferase; Reviewed; Region: rumA; PRK13168 871585010135 TRAM domain; Region: TRAM; pfam01938 871585010136 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 871585010137 S-adenosylmethionine binding site [chemical binding]; other site 871585010138 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 871585010139 HD domain; Region: HD_4; pfam13328 871585010140 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 871585010141 synthetase active site [active] 871585010142 NTP binding site [chemical binding]; other site 871585010143 metal binding site [ion binding]; metal-binding site 871585010144 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 871585010145 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 871585010146 short chain dehydrogenase; Provisional; Region: PRK08267 871585010147 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 871585010148 NAD(P) binding site [chemical binding]; other site 871585010149 active site 871585010150 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 871585010151 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 871585010152 homodimer interface [polypeptide binding]; other site 871585010153 metal binding site [ion binding]; metal-binding site 871585010154 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 871585010155 homodimer interface [polypeptide binding]; other site 871585010156 active site 871585010157 putative chemical substrate binding site [chemical binding]; other site 871585010158 metal binding site [ion binding]; metal-binding site 871585010159 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 871585010160 Helix-hairpin-helix motif; Region: HHH; pfam00633 871585010161 poly(A) polymerase; Region: pcnB; TIGR01942 871585010162 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 871585010163 active site 871585010164 NTP binding site [chemical binding]; other site 871585010165 metal binding triad [ion binding]; metal-binding site 871585010166 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 871585010167 Polymerase A arginine-rich C-terminus; Region: PolyA_pol_arg_C; pfam12626 871585010168 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 871585010169 catalytic center binding site [active] 871585010170 ATP binding site [chemical binding]; other site 871585010171 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 871585010172 oligomerization interface [polypeptide binding]; other site 871585010173 active site 871585010174 metal binding site [ion binding]; metal-binding site 871585010175 pantoate--beta-alanine ligase; Region: panC; TIGR00018 871585010176 Pantoate-beta-alanine ligase; Region: PanC; cd00560 871585010177 active site 871585010178 ATP-binding site [chemical binding]; other site 871585010179 pantoate-binding site; other site 871585010180 HXXH motif; other site 871585010181 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 871585010182 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 871585010183 dimerization domain swap beta strand [polypeptide binding]; other site 871585010184 regulatory protein interface [polypeptide binding]; other site 871585010185 active site 871585010186 regulatory phosphorylation site [posttranslational modification]; other site 871585010187 hypothetical protein; Provisional; Region: PRK05255 871585010188 acyl-CoA synthetase; Validated; Region: PRK08162 871585010189 Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles and Arabidopsis; Region: ttLC_FACS_AEE21_like; cd12118 871585010190 acyl-activating enzyme (AAE) consensus motif; other site 871585010191 putative active site [active] 871585010192 AMP binding site [chemical binding]; other site 871585010193 putative CoA binding site [chemical binding]; other site 871585010194 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 871585010195 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 871585010196 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 871585010197 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 871585010198 active site 871585010199 dimer interface [polypeptide binding]; other site 871585010200 motif 1; other site 871585010201 motif 2; other site 871585010202 motif 3; other site 871585010203 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 871585010204 anticodon binding site; other site 871585010205 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 871585010206 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 871585010207 GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972 871585010208 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 871585010209 C-terminal domain interface [polypeptide binding]; other site 871585010210 GSH binding site (G-site) [chemical binding]; other site 871585010211 dimer interface [polypeptide binding]; other site 871585010212 C-terminal, alpha helical domain of Escherichia coli YfcG Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YfcG_like; cd10291 871585010213 N-terminal domain interface [polypeptide binding]; other site 871585010214 putative dimer interface [polypeptide binding]; other site 871585010215 active site 871585010216 Predicted membrane protein [Function unknown]; Region: COG1238 871585010217 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 871585010218 putative substrate translocation pore; other site 871585010219 H+ Antiporter protein; Region: 2A0121; TIGR00900 871585010220 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 871585010221 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 871585010222 23S rRNA binding site [nucleotide binding]; other site 871585010223 L21 binding site [polypeptide binding]; other site 871585010224 L13 binding site [polypeptide binding]; other site 871585010225 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 871585010226 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 871585010227 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 871585010228 dimer interface [polypeptide binding]; other site 871585010229 motif 1; other site 871585010230 active site 871585010231 motif 2; other site 871585010232 motif 3; other site 871585010233 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 871585010234 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 871585010235 putative tRNA-binding site [nucleotide binding]; other site 871585010236 B3/4 domain; Region: B3_4; pfam03483 871585010237 tRNA synthetase B5 domain; Region: B5; smart00874 871585010238 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 871585010239 dimer interface [polypeptide binding]; other site 871585010240 motif 1; other site 871585010241 motif 3; other site 871585010242 motif 2; other site 871585010243 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 871585010244 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 871585010245 IHF dimer interface [polypeptide binding]; other site 871585010246 IHF - DNA interface [nucleotide binding]; other site 871585010247 transcription termination factor Rho; Provisional; Region: rho; PRK09376 871585010248 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 871585010249 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 871585010250 RNA binding site [nucleotide binding]; other site 871585010251 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 871585010252 multimer interface [polypeptide binding]; other site 871585010253 Walker A motif; other site 871585010254 ATP binding site [chemical binding]; other site 871585010255 Walker B motif; other site 871585010256 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 871585010257 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 871585010258 catalytic residues [active] 871585010259 guanosine pentaphosphate phosphohydrolase; Provisional; Region: PRK11031 871585010260 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 871585010261 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 871585010262 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 871585010263 TilS substrate binding domain; Region: TilS; pfam09179 871585010264 TilS substrate C-terminal domain; Region: TilS_C; pfam11734 871585010265 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 871585010266 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 871585010267 YGGT family; Region: YGGT; pfam02325 871585010268 DNA polymerase I; Provisional; Region: PRK05755 871585010269 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 871585010270 active site 871585010271 metal binding site 1 [ion binding]; metal-binding site 871585010272 putative 5' ssDNA interaction site; other site 871585010273 metal binding site 3; metal-binding site 871585010274 metal binding site 2 [ion binding]; metal-binding site 871585010275 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 871585010276 putative DNA binding site [nucleotide binding]; other site 871585010277 putative metal binding site [ion binding]; other site 871585010278 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 871585010279 active site 871585010280 catalytic site [active] 871585010281 substrate binding site [chemical binding]; other site 871585010282 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 871585010283 active site 871585010284 DNA binding site [nucleotide binding] 871585010285 catalytic site [active] 871585010286 Predicted membrane protein (DUF2339); Region: DUF2339; pfam10101 871585010287 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 871585010288 Mechanosensitive ion channel; Region: MS_channel; pfam00924 871585010289 Protein of unknown function (DUF432); Region: DUF432; cl01027 871585010290 type II secretion system protein E; Region: type_II_gspE; TIGR02533 871585010291 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 871585010292 Walker A motif; other site 871585010293 ATP binding site [chemical binding]; other site 871585010294 Walker B motif; other site 871585010295 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 871585010296 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 871585010297 MarR family; Region: MarR; pfam01047 871585010298 Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases); Region: nit; cd07572 871585010299 nitrilase; Region: PLN02798 871585010300 putative active site [active] 871585010301 catalytic triad [active] 871585010302 dimer interface [polypeptide binding]; other site 871585010303 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 871585010304 anti sigma factor interaction site; other site 871585010305 regulatory phosphorylation site [posttranslational modification]; other site 871585010306 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 871585010307 VacJ like lipoprotein; Region: VacJ; cl01073 871585010308 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 871585010309 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 871585010310 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 871585010311 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 871585010312 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 871585010313 30S subunit binding site; other site 871585010314 BolA-like protein; Region: BolA; cl00386 871585010315 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 871585010316 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 871585010317 hinge; other site 871585010318 active site 871585010319 ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040 871585010320 ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686 871585010321 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 871585010322 histidinol dehydrogenase; Region: hisD; TIGR00069 871585010323 NAD binding site [chemical binding]; other site 871585010324 dimerization interface [polypeptide binding]; other site 871585010325 product binding site; other site 871585010326 substrate binding site [chemical binding]; other site 871585010327 zinc binding site [ion binding]; other site 871585010328 catalytic residues [active] 871585010329 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 871585010330 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 871585010331 pyridoxal 5'-phosphate binding site [chemical binding]; other site 871585010332 homodimer interface [polypeptide binding]; other site 871585010333 catalytic residue [active] 871585010334 anthranilate synthase component I; Provisional; Region: PRK13570 871585010335 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 871585010336 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39G; cd02423 871585010337 putative active site [active] 871585010338 Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; cl17479 871585010339 potential frameshift: common BLAST hit: gi|299771490|ref|YP_003733516.1| FilE 871585010340 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 871585010341 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_4; cd04511 871585010342 nudix motif; other site 871585010343 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 871585010344 putative active site [active] 871585010345 putative CoA binding site [chemical binding]; other site 871585010346 nudix motif; other site 871585010347 metal binding site [ion binding]; metal-binding site 871585010348 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 871585010349 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 871585010350 trimer interface [polypeptide binding]; other site 871585010351 putative metal binding site [ion binding]; other site 871585010352 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 871585010353 Glycoprotease family; Region: Peptidase_M22; pfam00814 871585010354 Putative SAM-dependent methyltransferase; Region: SAM_MT; cl17517 871585010355 Peptidase C13 family; Region: Peptidase_C13; pfam01650 871585010356 S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821 871585010357 S-formylglutathione hydrolase; Region: PLN02442 871585010358 Uncharacterized protein conserved in bacteria (DUF2218); Region: DUF2218; pfam09981 871585010359 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 871585010360 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 871585010361 substrate binding site [chemical binding]; other site 871585010362 hexamer interface [polypeptide binding]; other site 871585010363 metal binding site [ion binding]; metal-binding site 871585010364 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 871585010365 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 871585010366 active site 871585010367 motif I; other site 871585010368 motif II; other site 871585010369 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 871585010370 copper-resistance protein, CopA family; Region: copper_res_A; TIGR01480 871585010371 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 871585010372 Multicopper oxidase; Region: Cu-oxidase; pfam00394 871585010373 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 871585010374 Copper resistance protein B precursor (CopB); Region: CopB; pfam05275 871585010375 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 871585010376 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 871585010377 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 871585010378 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 871585010379 DNA binding site [nucleotide binding] 871585010380 active site 871585010381 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 871585010382 heterotetramer interface [polypeptide binding]; other site 871585010383 active site pocket [active] 871585010384 cleavage site 871585010385 quinolinate synthetase; Provisional; Region: PRK09375 871585010386 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 871585010387 adenosine deaminase; Provisional; Region: PRK09358 871585010388 active site 871585010389 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 871585010390 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH8; cd08262 871585010391 putative NAD(P) binding site [chemical binding]; other site 871585010392 catalytic Zn binding site [ion binding]; other site 871585010393 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 871585010394 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 871585010395 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 871585010396 dimerization interface [polypeptide binding]; other site 871585010397 Glutaryl-CoA dehydrogenase; Region: GCD; cd01151 871585010398 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 871585010399 FAD binding site [chemical binding]; other site 871585010400 substrate binding pocket [chemical binding]; other site 871585010401 catalytic base [active] 871585010402 benzoate transport; Region: 2A0115; TIGR00895 871585010403 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 871585010404 putative substrate translocation pore; other site 871585010405 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 871585010406 nitrobindin heme-binding domain; Region: nitrobindin; cl10502 871585010407 CoA-transferase family III; Region: CoA_transf_3; pfam02515 871585010408 Glyoxalase-like domain; Region: Glyoxalase_3; pfam13468 871585010409 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 871585010410 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 871585010411 HPP family; Region: HPP; pfam04982 871585010412 tricarballylate utilization protein B; Provisional; Region: PRK15033 871585010413 tricarballylate dehydrogenase; Validated; Region: PRK08274 871585010414 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 871585010415 nitrogen assimilation transcriptional regulator; Provisional; Region: PRK11233 871585010416 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 871585010417 The C-teminal substrate binding domain of LysR-like nitrogen assimilation control (NAC) protein, contains the type 2 periplasmic binding fold; Region: PBP2_Nac; cd08433 871585010418 putative dimerization interface [polypeptide binding]; other site 871585010419 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 871585010420 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 871585010421 citrate-proton symporter; Provisional; Region: PRK15075 871585010422 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 871585010423 putative substrate translocation pore; other site 871585010424 Transcriptional regulator [Transcription]; Region: LysR; COG0583 871585010425 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 871585010426 The C-teminal substrate binding domain of LysR-like nitrogen assimilation control (NAC) protein, contains the type 2 periplasmic binding fold; Region: PBP2_Nac; cd08433 871585010427 putative dimerization interface [polypeptide binding]; other site 871585010428 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 871585010429 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 871585010430 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3333 871585010431 Putative ammonia monooxygenase; Region: AmoA; pfam05145 871585010432 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 871585010433 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 871585010434 Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; cl17479 871585010435 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 871585010436 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like6; cd05664 871585010437 metal binding site [ion binding]; metal-binding site 871585010438 putative dimer interface [polypeptide binding]; other site 871585010439 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 871585010440 SurA N-terminal domain; Region: SurA_N; pfam09312 871585010441 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 871585010442 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 871585010443 Fatty acid desaturase; Region: FA_desaturase; pfam00487 871585010444 LysE type translocator; Region: LysE; cl00565 871585010445 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 871585010446 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 871585010447 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 871585010448 dimerization interface [polypeptide binding]; other site 871585010449 Domain of unknown function (DUF1852); Region: DUF1852; pfam08908 871585010450 methionine synthase; Provisional; Region: PRK01207 871585010451 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 871585010452 substrate binding site [chemical binding]; other site 871585010453 THF binding site; other site 871585010454 zinc-binding site [ion binding]; other site 871585010455 Flavin Reductases; Region: FlaRed; cl00801 871585010456 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 871585010457 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 871585010458 potential frameshift: common BLAST hit: gi|169632875|ref|YP_001706611.1| outer membrane efflux protein, type I secretion protein 871585010459 Outer membrane efflux protein; Region: OEP; pfam02321 871585010460 Outer membrane efflux protein; Region: OEP; pfam02321 871585010461 type I secretion system ATPase, LssB family; Region: type_I_sec_LssB; TIGR03375 871585010462 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 871585010463 putative active site [active] 871585010464 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 871585010465 ATP-binding cassette domain of bacteriocin exporters, subfamily C; Region: ABCC_bacteriocin_exporters; cd03245 871585010466 Walker A/P-loop; other site 871585010467 ATP binding site [chemical binding]; other site 871585010468 Q-loop/lid; other site 871585010469 ABC transporter signature motif; other site 871585010470 Walker B; other site 871585010471 D-loop; other site 871585010472 H-loop/switch region; other site 871585010473 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 871585010474 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 871585010475 HlyD family secretion protein; Region: HlyD_3; pfam13437 871585010476 Translation initiation factor 2 (IF-2; GTPase) [Translation, ribosomal structure and biogenesis]; Region: InfB; COG0532