-- dump date 20140618_191006 -- class Genbank::misc_feature -- table misc_feature_note -- id note 436717000001 DnaA N-terminal domain; Region: DnaA_N; pfam11638 436717000002 chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362 436717000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 436717000004 Walker A motif; other site 436717000005 ATP binding site [chemical binding]; other site 436717000006 Walker B motif; other site 436717000007 arginine finger; other site 436717000008 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 436717000009 DnaA box-binding interface [nucleotide binding]; other site 436717000010 DNA polymerase III subunit beta; Validated; Region: PRK05643 436717000011 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 436717000012 putative DNA binding surface [nucleotide binding]; other site 436717000013 dimer interface [polypeptide binding]; other site 436717000014 beta-clamp/clamp loader binding surface; other site 436717000015 beta-clamp/translesion DNA polymerase binding surface; other site 436717000016 recombination protein F; Reviewed; Region: recF; PRK00064 436717000017 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 436717000018 Walker A/P-loop; other site 436717000019 ATP binding site [chemical binding]; other site 436717000020 Q-loop/lid; other site 436717000021 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 436717000022 ABC transporter signature motif; other site 436717000023 Walker B; other site 436717000024 D-loop; other site 436717000025 H-loop/switch region; other site 436717000026 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 436717000027 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 436717000028 Mg2+ binding site [ion binding]; other site 436717000029 G-X-G motif; other site 436717000030 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 436717000031 anchoring element; other site 436717000032 dimer interface [polypeptide binding]; other site 436717000033 ATP binding site [chemical binding]; other site 436717000034 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 436717000035 active site 436717000036 putative metal-binding site [ion binding]; other site 436717000037 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 436717000038 Cytochrome b562; Region: Cytochrom_B562; cl01546 436717000039 Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823 436717000040 putative ABC transporter ATP-binding protein; Provisional; Region: PRK10636 436717000041 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 436717000042 ABC transporter; Region: ABC_tran_2; pfam12848 436717000043 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 436717000044 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 436717000045 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 436717000046 iron-sulfur cluster insertion protein ErpA; Provisional; Region: PRK13623 436717000047 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 436717000048 anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585 436717000049 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 436717000050 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 436717000051 active site 436717000052 HIGH motif; other site 436717000053 dimer interface [polypeptide binding]; other site 436717000054 KMSKS motif; other site 436717000055 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 436717000056 GST_N family, unknown subfamily 4; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_4; cd03056 436717000057 putative C-terminal domain interface [polypeptide binding]; other site 436717000058 putative GSH binding site (G-site) [chemical binding]; other site 436717000059 putative dimer interface [polypeptide binding]; other site 436717000060 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 436717000061 dimer interface [polypeptide binding]; other site 436717000062 N-terminal domain interface [polypeptide binding]; other site 436717000063 substrate binding pocket (H-site) [chemical binding]; other site 436717000064 outer membrane protein; Region: OMP_w_GlyGly; TIGR04219 436717000065 uncharacterized bacterial and archaeal solute carrier 6 subfamily; solute-binding domain; Region: SLC6sbd_u1; cd10334 436717000066 Na2 binding site [ion binding]; other site 436717000067 putative substrate binding site 1 [chemical binding]; other site 436717000068 Na binding site 1 [ion binding]; other site 436717000069 putative substrate binding site 2 [chemical binding]; other site 436717000070 16S rRNA methyltransferase B; Provisional; Region: PRK10901 436717000071 NusB family; Region: NusB; pfam01029 436717000072 putative RNA binding site [nucleotide binding]; other site 436717000073 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 436717000074 S-adenosylmethionine binding site [chemical binding]; other site 436717000075 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 436717000076 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 436717000077 putative active site [active] 436717000078 substrate binding site [chemical binding]; other site 436717000079 putative cosubstrate binding site; other site 436717000080 catalytic site [active] 436717000081 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 436717000082 substrate binding site [chemical binding]; other site 436717000083 dihydroxy-acid dehydratase; Provisional; Region: PRK12448 436717000084 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 436717000085 Transcriptional regulator [Transcription]; Region: LysR; COG0583 436717000086 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 436717000087 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 436717000088 dimerization interface [polypeptide binding]; other site 436717000089 pyrimidine utilization transport protein G; Region: RutG; TIGR03616 436717000090 phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009 436717000091 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 436717000092 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 436717000093 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 436717000094 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 436717000095 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 436717000096 HlyD family secretion protein; Region: HlyD_3; pfam13437 436717000097 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 436717000098 Inorganic H+ pyrophosphatase; Region: H_PPase; pfam03030 436717000099 chaperone protein DnaJ; Provisional; Region: PRK10767 436717000100 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 436717000101 HSP70 interaction site [polypeptide binding]; other site 436717000102 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 436717000103 substrate binding site [polypeptide binding]; other site 436717000104 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 436717000105 Zn binding sites [ion binding]; other site 436717000106 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 436717000107 dimer interface [polypeptide binding]; other site 436717000108 dihydrodipicolinate reductase; Provisional; Region: PRK00048 436717000109 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 436717000110 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 436717000111 Uncharacterized subgroup of the steroidogenic acute regulatory protein (StAR)-related lipid transfer (START) domain family; Region: START_1; cd08876 436717000112 putative lipid binding site [chemical binding]; other site 436717000113 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 436717000114 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 436717000115 putative substrate translocation pore; other site 436717000116 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 436717000117 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 436717000118 active site 436717000119 catalytic tetrad [active] 436717000120 Transcriptional regulator [Transcription]; Region: LysR; COG0583 436717000121 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 436717000122 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA; cd08478 436717000123 putative effector binding pocket; other site 436717000124 dimerization interface [polypeptide binding]; other site 436717000125 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 436717000126 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 436717000127 DNA-binding site [nucleotide binding]; DNA binding site 436717000128 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 436717000129 pyridoxal 5'-phosphate binding site [chemical binding]; other site 436717000130 homodimer interface [polypeptide binding]; other site 436717000131 catalytic residue [active] 436717000132 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 436717000133 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 436717000134 putative NAD(P) binding site [chemical binding]; other site 436717000135 putative substrate binding site [chemical binding]; other site 436717000136 catalytic Zn binding site [ion binding]; other site 436717000137 structural Zn binding site [ion binding]; other site 436717000138 dimer interface [polypeptide binding]; other site 436717000139 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 436717000140 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 436717000141 Peptidase family M23; Region: Peptidase_M23; pfam01551 436717000142 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 436717000143 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 436717000144 minor groove reading motif; other site 436717000145 helix-hairpin-helix signature motif; other site 436717000146 substrate binding pocket [chemical binding]; other site 436717000147 active site 436717000148 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 436717000149 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 436717000150 DNA binding and oxoG recognition site [nucleotide binding] 436717000151 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 436717000152 nucleotide binding site/active site [active] 436717000153 HIT family signature motif; other site 436717000154 catalytic residue [active] 436717000155 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 436717000156 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 436717000157 Small integral membrane protein [Function unknown]; Region: COG5487; cl17674 436717000158 hypothetical protein; Provisional; Region: PRK05170 436717000159 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 436717000160 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 436717000161 recombination factor protein RarA; Reviewed; Region: PRK13342 436717000162 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 436717000163 Walker A motif; other site 436717000164 ATP binding site [chemical binding]; other site 436717000165 Walker B motif; other site 436717000166 arginine finger; other site 436717000167 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 436717000168 Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226 436717000169 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 436717000170 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 436717000171 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 436717000172 ATP binding site [chemical binding]; other site 436717000173 active site 436717000174 substrate binding site [chemical binding]; other site 436717000175 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 436717000176 dihydrodipicolinate synthase; Region: dapA; TIGR00674 436717000177 dimer interface [polypeptide binding]; other site 436717000178 active site 436717000179 catalytic residue [active] 436717000180 Isochorismatase family; Region: Isochorismatase; pfam00857 436717000181 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 436717000182 catalytic triad [active] 436717000183 metal binding site [ion binding]; metal-binding site 436717000184 conserved cis-peptide bond; other site 436717000185 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 436717000186 Sodium Bile acid symporter family; Region: SBF; pfam01758 436717000187 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 436717000188 putative efflux protein, MATE family; Region: matE; TIGR00797 436717000189 cation binding site [ion binding]; other site 436717000190 Uncharacterized conserved protein [Function unknown]; Region: COG1683 436717000191 4-hydroxyphenylpyruvate dioxygenase and related hemolysins [Amino acid transport and metabolism / General function prediction only]; Region: COG3185 436717000192 N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342 436717000193 dimer interface [polypeptide binding]; other site 436717000194 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250 436717000195 active site 436717000196 Fe binding site [ion binding]; other site 436717000197 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 436717000198 Transcriptional regulator [Transcription]; Region: IclR; COG1414 436717000199 Bacterial transcriptional regulator; Region: IclR; pfam01614 436717000200 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 436717000201 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 436717000202 Zn binding site [ion binding]; other site 436717000203 GST_N family, Class Zeta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Zeta; cd03042 436717000204 maleylacetoacetate isomerase; Region: maiA; TIGR01262 436717000205 C-terminal domain interface [polypeptide binding]; other site 436717000206 GSH binding site (G-site) [chemical binding]; other site 436717000207 putative dimer interface [polypeptide binding]; other site 436717000208 C-terminal, alpha helical domain of Class Zeta Glutathione S-transferases; Region: GST_C_Zeta; cd03191 436717000209 dimer interface [polypeptide binding]; other site 436717000210 N-terminal domain interface [polypeptide binding]; other site 436717000211 maleylacetoacetate (MAA) substrate binding site (H site) [chemical binding]; other site 436717000212 fumarylacetoacetase; Region: PLN02856 436717000213 Domain of unknown function (DUF1969); Region: DUF1969; pfam09298 436717000214 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 436717000215 aromatic amino acid transporter; Provisional; Region: PRK10238 436717000216 Peptidase M15; Region: Peptidase_M15_3; cl01194 436717000217 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 436717000218 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 436717000219 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 436717000220 Acyltransferase family; Region: Acyl_transf_3; pfam01757 436717000221 histidine utilization repressor, proteobacterial; Region: his_ut_repres; TIGR02018 436717000222 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 436717000223 DNA-binding site [nucleotide binding]; DNA binding site 436717000224 UTRA domain; Region: UTRA; pfam07702 436717000225 HutD; Region: HutD; pfam05962 436717000226 urocanate hydratase; Provisional; Region: PRK05414 436717000227 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 436717000228 active sites [active] 436717000229 tetramer interface [polypeptide binding]; other site 436717000230 putative proline-specific permease; Provisional; Region: proY; PRK10580 436717000231 imidazolonepropionase; Validated; Region: PRK09356 436717000232 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296 436717000233 active site 436717000234 agmatinase; Region: agmatinase; TIGR01230 436717000235 Formimidoylglutamase or HutE; Region: Formimidoylglutamase; cd09988 436717000236 putative active site [active] 436717000237 putative metal binding site [ion binding]; other site 436717000238 Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960 436717000239 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 436717000240 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 436717000241 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 436717000242 motif II; other site 436717000243 glutamate racemase; Provisional; Region: PRK00865 436717000244 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 436717000245 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 436717000246 glutaminase active site [active] 436717000247 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 436717000248 dimer interface [polypeptide binding]; other site 436717000249 active site 436717000250 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 436717000251 dimer interface [polypeptide binding]; other site 436717000252 active site 436717000253 N-acetylglucosamine-1-phosphate uridyltransferase (contains nucleotidyltransferase and I-patch acetyltransferase domains) [Cell envelope biogenesis, outer membrane]; Region: GlmU; COG1207 436717000254 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 436717000255 Substrate binding site; other site 436717000256 Mg++ binding site; other site 436717000257 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 436717000258 active site 436717000259 substrate binding site [chemical binding]; other site 436717000260 CoA binding site [chemical binding]; other site 436717000261 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 436717000262 tetramer interfaces [polypeptide binding]; other site 436717000263 binuclear metal-binding site [ion binding]; other site 436717000264 thiamine monophosphate kinase; Provisional; Region: PRK05731 436717000265 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 436717000266 ATP binding site [chemical binding]; other site 436717000267 dimerization interface [polypeptide binding]; other site 436717000268 transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202 436717000269 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 436717000270 homopentamer interface [polypeptide binding]; other site 436717000271 active site 436717000272 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II-like protein; Provisional; Region: PRK14019 436717000273 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 436717000274 GTP cyclohydrolase II; Region: GTP_cyclohydro2; pfam00925 436717000275 dimerization interface [polypeptide binding]; other site 436717000276 active site 436717000277 Domain of unknown function (DUF4175); Region: DUF4175; pfam13779 436717000278 CT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_1; cd04870 436717000279 ACT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_2; cd04871 436717000280 phosphoserine phosphatase SerB; Region: serB; TIGR00338 436717000281 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 436717000282 motif II; other site 436717000283 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 436717000284 putative active site [active] 436717000285 dimerization interface [polypeptide binding]; other site 436717000286 putative tRNAtyr binding site [nucleotide binding]; other site 436717000287 nicotinate phosphoribosyltransferase; Region: NAPRTase; TIGR01514 436717000288 Nicotinate phosphoribosyltransferase (NAPRTase), related to PncB. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting; Region: PncB_like; cd01401 436717000289 active site 436717000290 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 436717000291 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 436717000292 active site residue [active] 436717000293 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 436717000294 active site residue [active] 436717000295 phosphatidylserine decarboxylase; Reviewed; Region: psd; PRK00044 436717000296 Predicted acetamidase/formamidase [Energy production and conversion]; Region: COG2421 436717000297 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 436717000298 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 436717000299 Secretory lipase; Region: LIP; pfam03583 436717000300 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 436717000301 Domain of unknown function (DUF3329); Region: DUF3329; pfam11808 436717000302 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 436717000303 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 436717000304 putative active site [active] 436717000305 heme pocket [chemical binding]; other site 436717000306 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 436717000307 dimer interface [polypeptide binding]; other site 436717000308 phosphorylation site [posttranslational modification] 436717000309 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 436717000310 ATP binding site [chemical binding]; other site 436717000311 Mg2+ binding site [ion binding]; other site 436717000312 G-X-G motif; other site 436717000313 phosphate regulon transcriptional regulatory protein PhoB; Region: PhoB; TIGR02154 436717000314 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 436717000315 active site 436717000316 phosphorylation site [posttranslational modification] 436717000317 intermolecular recognition site; other site 436717000318 dimerization interface [polypeptide binding]; other site 436717000319 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 436717000320 DNA binding site [nucleotide binding] 436717000321 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 436717000322 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 436717000323 short chain dehydrogenase; Provisional; Region: PRK07832 436717000324 NAD(P) binding site [chemical binding]; other site 436717000325 active site 436717000326 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 436717000327 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138 436717000328 methionine aminotransferase; Validated; Region: PRK09082 436717000329 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 436717000330 pyridoxal 5'-phosphate binding site [chemical binding]; other site 436717000331 homodimer interface [polypeptide binding]; other site 436717000332 catalytic residue [active] 436717000333 Protein of unknown function (DUF445); Region: DUF445; pfam04286 436717000334 Bacterial protein of unknown function (DUF924); Region: DUF924; pfam06041 436717000335 Glutamate-cysteine ligase; Region: Glu_cys_ligase; cl17352 436717000336 Disulfide bond formation protein DsbB; Region: DsbB; pfam02600 436717000337 Uncharacterized protein conserved in bacteria [Function unknown]; Region: VgrG; COG3501 436717000338 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 436717000339 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 436717000340 Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296 436717000341 Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; pfam10106 436717000342 Protein of unknown function (DUF1311); Region: DUF1311; pfam07007 436717000343 PGAP1-like protein; Region: PGAP1; pfam07819 436717000344 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 436717000345 Uncharacterized protein family (UPF0227); Region: UPF0227; cl14886 436717000346 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 436717000347 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 436717000348 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 436717000349 ATP binding site [chemical binding]; other site 436717000350 Mg2+ binding site [ion binding]; other site 436717000351 G-X-G motif; other site 436717000352 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 436717000353 anchoring element; other site 436717000354 dimer interface [polypeptide binding]; other site 436717000355 ATP binding site [chemical binding]; other site 436717000356 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 436717000357 active site 436717000358 metal binding site [ion binding]; metal-binding site 436717000359 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 436717000360 ureidoglycolate hydrolase; Provisional; Region: PRK03606 436717000361 Ureidoglycolate hydrolase [Nucleotide transport and metabolism]; Region: DAL3; COG3194 436717000362 allantoicase; Region: allantoicase; TIGR02961 436717000363 Allantoicase repeat; Region: Allantoicase; pfam03561 436717000364 Allantoicase repeat; Region: Allantoicase; pfam03561 436717000365 hypothetical protein; Provisional; Region: PRK07236 436717000366 FAD binding domain; Region: FAD_binding_3; pfam01494 436717000367 Nucleoside-specific channel-forming protein, Tsx; Region: Channel_Tsx; cl04114 436717000368 xanthine permease; Region: pbuX; TIGR03173 436717000369 HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822 436717000370 active site 436717000371 homotetramer interface [polypeptide binding]; other site 436717000372 putative OHCU decarboxylase; Provisional; Region: PRK13798 436717000373 putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212 436717000374 Catalytic domain of bacterial PuuE allantoinases, Schizosaccharomyces pombe chitin deacetylase 1 (SpCDA1), and similar proteins; Region: CE4_PuuE_SpCDA1; cd10977 436717000375 active site 436717000376 catalytic site [active] 436717000377 tetramer interface [polypeptide binding]; other site 436717000378 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cl00250 436717000379 30S subunit binding site; other site 436717000380 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 436717000381 Ankyrin repeats (many copies); Region: Ank_5; pfam13857 436717000382 Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; pfam13557 436717000383 thiol:disulfide interchange protein precursor; Provisional; Region: dipZ; PRK00293 436717000384 Disulphide bond corrector protein DsbC; Region: DsbC; pfam11412 436717000385 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 436717000386 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 436717000387 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 436717000388 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 436717000389 metal binding site [ion binding]; metal-binding site 436717000390 active site 436717000391 I-site; other site 436717000392 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 436717000393 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 436717000394 Glutathionylspermidine synthase preATP-grasp; Region: GSP_synth; cl00503 436717000395 Uncharacterized protein conserved in bacteria (DUF2147); Region: DUF2147; pfam09917 436717000396 Arsenate Reductase (ArsC) family, Yffb subfamily; Yffb is an uncharacterized bacterial protein encoded by the yffb gene, related to the thioredoxin-fold arsenic reductases, ArsC. The structure of Yffb and the conservation of the catalytic cysteine...; Region: ArsC_Yffb; cd03035 436717000397 ArsC family; Region: ArsC; pfam03960 436717000398 putative catalytic residues [active] 436717000399 Neisseria meningitides Nape-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Nape_like_AP-endo; cd10281 436717000400 putative active site [active] 436717000401 putative catalytic site [active] 436717000402 putative DNA binding site [nucleotide binding]; other site 436717000403 putative phosphate binding site [ion binding]; other site 436717000404 metal binding site A [ion binding]; metal-binding site 436717000405 putative AP binding site [nucleotide binding]; other site 436717000406 putative metal binding site B [ion binding]; other site 436717000407 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 436717000408 active site 436717000409 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 436717000410 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 436717000411 N-terminal plug; other site 436717000412 ligand-binding site [chemical binding]; other site 436717000413 Domain of unknown function (DUF1737); Region: DUF1737; pfam08410 436717000414 glutathione synthetase; Provisional; Region: PRK05246 436717000415 Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951 436717000416 Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955 436717000417 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 436717000418 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 436717000419 active site 436717000420 homodimer interface [polypeptide binding]; other site 436717000421 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 436717000422 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 436717000423 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 436717000424 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 436717000425 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 436717000426 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 436717000427 ATP-grasp domain; Region: ATP-grasp_4; cl17255 436717000428 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 436717000429 Cell division protein FtsQ; Region: FtsQ; pfam03799 436717000430 cell division protein FtsA; Region: ftsA; TIGR01174 436717000431 Cell division protein FtsA; Region: FtsA; smart00842 436717000432 Cell division protein FtsA; Region: FtsA; pfam14450 436717000433 cell division protein FtsZ; Validated; Region: PRK09330 436717000434 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 436717000435 nucleotide binding site [chemical binding]; other site 436717000436 SulA interaction site; other site 436717000437 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186 436717000438 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 436717000439 Protein of unknown function (DUF721); Region: DUF721; cl02324 436717000440 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 436717000441 Peptidase family M23; Region: Peptidase_M23; pfam01551 436717000442 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 436717000443 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 436717000444 dimer interface [polypeptide binding]; other site 436717000445 TPP-binding site [chemical binding]; other site 436717000446 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 436717000447 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 436717000448 pyruvate dehydrogenase dihydrolipoyltransacetylase; Validated; Region: aceF; PRK11854 436717000449 E3 interaction surface; other site 436717000450 lipoyl attachment site [posttranslational modification]; other site 436717000451 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 436717000452 E3 interaction surface; other site 436717000453 lipoyl attachment site [posttranslational modification]; other site 436717000454 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 436717000455 E3 interaction surface; other site 436717000456 lipoyl attachment site [posttranslational modification]; other site 436717000457 e3 binding domain; Region: E3_binding; pfam02817 436717000458 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 436717000459 Predicted membrane protein [Function unknown]; Region: COG2119 436717000460 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 436717000461 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 436717000462 ferrichrome receptor precursor protein; Provisional; Region: PRK14050 436717000463 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 436717000464 N-terminal plug; other site 436717000465 ligand-binding site [chemical binding]; other site 436717000466 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 436717000467 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 436717000468 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 436717000469 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 436717000470 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 436717000471 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 436717000472 active site 436717000473 phosphoglucosamine mutase; Provisional; Region: glmM; PRK10887 436717000474 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 436717000475 active site 436717000476 substrate binding site [chemical binding]; other site 436717000477 metal binding site [ion binding]; metal-binding site 436717000478 pyridoxamine-phosphate oxidase; Region: pdxH; TIGR00558 436717000479 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 436717000480 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 436717000481 ssDNA exonuclease RecJ; Provisional; Region: PRK11070 436717000482 DHH family; Region: DHH; pfam01368 436717000483 DHHA1 domain; Region: DHHA1; pfam02272 436717000484 peptide chain release factor 2; Provisional; Region: PRK08787 436717000485 This domain is found in peptide chain release factors; Region: PCRF; smart00937 436717000486 RF-1 domain; Region: RF-1; pfam00472 436717000487 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 436717000488 putative DNA binding site [nucleotide binding]; other site 436717000489 dimerization interface [polypeptide binding]; other site 436717000490 putative Zn2+ binding site [ion binding]; other site 436717000491 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 436717000492 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 436717000493 FMN binding site [chemical binding]; other site 436717000494 active site 436717000495 substrate binding site [chemical binding]; other site 436717000496 catalytic residue [active] 436717000497 3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749 436717000498 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 436717000499 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 436717000500 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 436717000501 RNA methyltransferase, RsmE family; Region: TIGR00046 436717000502 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 436717000503 Mechanosensitive ion channel; Region: MS_channel; pfam00924 436717000504 Protein of unknown function (DUF805); Region: DUF805; pfam05656 436717000505 acetyl-CoA synthetase; Provisional; Region: PRK00174 436717000506 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 436717000507 active site 436717000508 CoA binding site [chemical binding]; other site 436717000509 acyl-activating enzyme (AAE) consensus motif; other site 436717000510 AMP binding site [chemical binding]; other site 436717000511 acetate binding site [chemical binding]; other site 436717000512 Isochorismatase family; Region: Isochorismatase; pfam00857 436717000513 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 436717000514 catalytic triad [active] 436717000515 conserved cis-peptide bond; other site 436717000516 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 436717000517 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 436717000518 putative DNA binding site [nucleotide binding]; other site 436717000519 putative Zn2+ binding site [ion binding]; other site 436717000520 AsnC family; Region: AsnC_trans_reg; pfam01037 436717000521 dimethyl sulfone monooxygenase SfnG; Region: LLM_DMSO2_sfnG; TIGR04021 436717000522 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 436717000523 active site 436717000524 dimer interface [polypeptide binding]; other site 436717000525 non-prolyl cis peptide bond; other site 436717000526 insertion regions; other site 436717000527 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 436717000528 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 436717000529 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 436717000530 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 436717000531 active site 436717000532 phosphorylation site [posttranslational modification] 436717000533 intermolecular recognition site; other site 436717000534 dimerization interface [polypeptide binding]; other site 436717000535 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 436717000536 DNA binding residues [nucleotide binding] 436717000537 dimerization interface [polypeptide binding]; other site 436717000538 Na+/proline symporter [Amino acid transport and metabolism / General function prediction only]; Region: PutP; COG0591 436717000539 Na binding site [ion binding]; other site 436717000540 PAS fold; Region: PAS_7; pfam12860 436717000541 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 436717000542 putative active site [active] 436717000543 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 436717000544 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 436717000545 dimer interface [polypeptide binding]; other site 436717000546 phosphorylation site [posttranslational modification] 436717000547 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 436717000548 ATP binding site [chemical binding]; other site 436717000549 Mg2+ binding site [ion binding]; other site 436717000550 G-X-G motif; other site 436717000551 Response regulator receiver domain; Region: Response_reg; pfam00072 436717000552 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 436717000553 active site 436717000554 phosphorylation site [posttranslational modification] 436717000555 intermolecular recognition site; other site 436717000556 dimerization interface [polypeptide binding]; other site 436717000557 Protein of unknown function, DUF485; Region: DUF485; pfam04341 436717000558 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 436717000559 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 436717000560 Na binding site [ion binding]; other site 436717000561 BCCT family transporter; Region: BCCT; pfam02028 436717000562 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 436717000563 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 436717000564 metal binding site [ion binding]; metal-binding site 436717000565 active site 436717000566 I-site; other site 436717000567 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 436717000568 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 436717000569 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 436717000570 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 436717000571 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 436717000572 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 436717000573 2-enoyl thioester reductase (ETR) like proteins, child 2; Region: ETR_like_2; cd08292 436717000574 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 436717000575 putative NAD(P) binding site [chemical binding]; other site 436717000576 putative dimer interface [polypeptide binding]; other site 436717000577 Protein of unknown function (DUF1304); Region: DUF1304; pfam06993 436717000578 GlpM protein; Region: GlpM; pfam06942 436717000579 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 436717000580 classical (c) SDRs; Region: SDR_c; cd05233 436717000581 NAD(P) binding site [chemical binding]; other site 436717000582 active site 436717000583 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 436717000584 DNA binding residues [nucleotide binding] 436717000585 Putative transcription activator [Transcription]; Region: TenA; COG0819 436717000586 hypothetical protein; Provisional; Region: PRK14013 436717000587 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 436717000588 Major Facilitator Superfamily; Region: MFS_1; pfam07690 436717000589 putative substrate translocation pore; other site 436717000590 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 436717000591 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 436717000592 dimer interface [polypeptide binding]; other site 436717000593 ssDNA binding site [nucleotide binding]; other site 436717000594 tetramer (dimer of dimers) interface [polypeptide binding]; other site 436717000595 AzlC protein; Region: AzlC; cl00570 436717000596 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 436717000597 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 436717000598 non-specific DNA binding site [nucleotide binding]; other site 436717000599 salt bridge; other site 436717000600 sequence-specific DNA binding site [nucleotide binding]; other site 436717000601 Cupin domain; Region: Cupin_2; pfam07883 436717000602 gamma-aminobutyrate permease; Region: GABAperm; TIGR01773 436717000603 Spore germination protein; Region: Spore_permease; cl17796 436717000604 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 436717000605 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 436717000606 DNA-binding site [nucleotide binding]; DNA binding site 436717000607 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 436717000608 pyridoxal 5'-phosphate binding site [chemical binding]; other site 436717000609 homodimer interface [polypeptide binding]; other site 436717000610 catalytic residue [active] 436717000611 4-aminobutyrate aminotransferase; Provisional; Region: PRK06777 436717000612 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 436717000613 inhibitor-cofactor binding pocket; inhibition site 436717000614 pyridoxal 5'-phosphate binding site [chemical binding]; other site 436717000615 catalytic residue [active] 436717000616 succinic semialdehyde dehydrogenase; Region: PLN02278 436717000617 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 436717000618 tetramerization interface [polypeptide binding]; other site 436717000619 NAD(P) binding site [chemical binding]; other site 436717000620 catalytic residues [active] 436717000621 LysR family transcriptional regulator; Provisional; Region: PRK14997 436717000622 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 436717000623 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 436717000624 dimerization interface [polypeptide binding]; other site 436717000625 Isochorismatase family; Region: Isochorismatase; pfam00857 436717000626 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 436717000627 catalytic triad [active] 436717000628 dimer interface [polypeptide binding]; other site 436717000629 conserved cis-peptide bond; other site 436717000630 Pirin-related protein [General function prediction only]; Region: COG1741 436717000631 Pirin; Region: Pirin; pfam02678 436717000632 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 436717000633 Predicted NAD/FAD-binding protein [General function prediction only]; Region: COG2907 436717000634 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 436717000635 Methyltransferase domain; Region: Methyltransf_31; pfam13847 436717000636 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 436717000637 S-adenosylmethionine binding site [chemical binding]; other site 436717000638 Uncharacterized conserved protein [Function unknown]; Region: COG3791 436717000639 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 436717000640 putative active site pocket [active] 436717000641 dimerization interface [polypeptide binding]; other site 436717000642 putative catalytic residue [active] 436717000643 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 436717000644 Major Facilitator Superfamily; Region: MFS_1; pfam07690 436717000645 putative substrate translocation pore; other site 436717000646 Major Facilitator Superfamily; Region: MFS_1; pfam07690 436717000647 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 436717000648 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 436717000649 The C-terminal substrate binding domain of LysR-type transcrptional regulator BudR, which is responsible for activation of the expression of the butanediol operon genes; contains the type 2 periplasmic binding fold; Region: PBP2_BudR; cd08451 436717000650 putative dimerization interface [polypeptide binding]; other site 436717000651 putative substrate binding pocket [chemical binding]; other site 436717000652 Pyoverdine/dityrosine biosynthesis protein [Secondary metabolites biosynthesis, transport, and catabolism]; Region: DIT1; COG3207 436717000653 Pyoverdine/dityrosine biosynthesis protein; Region: DIT1_PvcA; pfam05141 436717000654 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 436717000655 Taurine catabolism dioxygenase TauD, TfdA family; Region: TauD; pfam02668 436717000656 substrate binding pocket [chemical binding]; other site 436717000657 active site 436717000658 iron coordination sites [ion binding]; other site 436717000659 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 436717000660 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 436717000661 HlyD family secretion protein; Region: HlyD_3; pfam13437 436717000662 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 436717000663 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 436717000664 EamA-like transporter family; Region: EamA; pfam00892 436717000665 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 436717000666 catalytic loop [active] 436717000667 iron binding site [ion binding]; other site 436717000668 Oxidoreductase FAD-binding domain; Region: FAD_binding_6; pfam00970 436717000669 hypothetical protein; Provisional; Region: PRK07206 436717000670 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 436717000671 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 436717000672 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 436717000673 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 436717000674 active site 436717000675 catalytic tetrad [active] 436717000676 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 436717000677 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 436717000678 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 436717000679 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 436717000680 Predicted transcriptional regulators [Transcription]; Region: COG1733 436717000681 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 436717000682 Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525 436717000683 isoprenoid biosynthesis protein with amidotransferase-like domain; Provisional; Region: PRK11780 436717000684 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 436717000685 conserved cys residue [active] 436717000686 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 436717000687 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 436717000688 K+ transporter [Inorganic ion transport and metabolism]; Region: Kup; COG3158 436717000689 potassium uptake protein; Region: kup; TIGR00794 436717000690 DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases. They exists as monomers and homodimers; Region: NUC; cd00091 436717000691 DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892 436717000692 active site 436717000693 substrate binding site [chemical binding]; other site 436717000694 Mg2+ binding site [ion binding]; other site 436717000695 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 436717000696 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 436717000697 amphipathic channel; other site 436717000698 Asn-Pro-Ala signature motifs; other site 436717000699 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 436717000700 Helix-turn-helix domain; Region: HTH_18; pfam12833 436717000701 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 436717000702 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 436717000703 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 436717000704 substrate binding site [chemical binding]; other site 436717000705 glutamase interaction surface [polypeptide binding]; other site 436717000706 Homoserine Kinase, type II. Homoserine kinase is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and...; Region: HomoserineK_II; cd05153 436717000707 Phosphotransferase enzyme family; Region: APH; pfam01636 436717000708 putative active site [active] 436717000709 putative substrate binding site [chemical binding]; other site 436717000710 ATP binding site [chemical binding]; other site 436717000711 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 436717000712 DNA-binding site [nucleotide binding]; DNA binding site 436717000713 RNA-binding motif; other site 436717000714 Protein of unknown function (DUF1294); Region: DUF1294; pfam06961 436717000715 Predicted membrane protein [Function unknown]; Region: COG3671 436717000716 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 436717000717 EamA-like transporter family; Region: EamA; pfam00892 436717000718 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 436717000719 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 436717000720 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 436717000721 non-specific DNA binding site [nucleotide binding]; other site 436717000722 salt bridge; other site 436717000723 sequence-specific DNA binding site [nucleotide binding]; other site 436717000724 Cupin domain; Region: Cupin_2; pfam07883 436717000725 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 436717000726 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 436717000727 Walker A/P-loop; other site 436717000728 ATP binding site [chemical binding]; other site 436717000729 Q-loop/lid; other site 436717000730 ABC transporter signature motif; other site 436717000731 Walker B; other site 436717000732 D-loop; other site 436717000733 H-loop/switch region; other site 436717000734 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 436717000735 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 436717000736 catalytic residues [active] 436717000737 DEDDy 3'-5' exonuclease domain of WRN and similar proteins; Region: WRN_exo; cd06141 436717000738 catalytic site [active] 436717000739 putative active site [active] 436717000740 putative substrate binding site [chemical binding]; other site 436717000741 Protein of unknown function (DUF805); Region: DUF805; pfam05656 436717000742 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141 436717000743 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 436717000744 putative active site [active] 436717000745 oxyanion strand; other site 436717000746 catalytic triad [active] 436717000747 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 436717000748 putative active site pocket [active] 436717000749 4-fold oligomerization interface [polypeptide binding]; other site 436717000750 metal binding residues [ion binding]; metal-binding site 436717000751 3-fold/trimer interface [polypeptide binding]; other site 436717000752 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 436717000753 Coenzyme A binding pocket [chemical binding]; other site 436717000754 putative acetyltransferase; Provisional; Region: PRK03624 436717000755 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 436717000756 Coenzyme A binding pocket [chemical binding]; other site 436717000757 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 436717000758 succinate CoA transferase; Region: YgfH_subfam; TIGR03458 436717000759 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 436717000760 osmolarity sensor protein; Provisional; Region: envZ; PRK09467 436717000761 HAMP domain; Region: HAMP; pfam00672 436717000762 dimerization interface [polypeptide binding]; other site 436717000763 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 436717000764 dimer interface [polypeptide binding]; other site 436717000765 phosphorylation site [posttranslational modification] 436717000766 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 436717000767 ATP binding site [chemical binding]; other site 436717000768 Mg2+ binding site [ion binding]; other site 436717000769 G-X-G motif; other site 436717000770 osmolarity response regulator; Provisional; Region: ompR; PRK09468 436717000771 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 436717000772 active site 436717000773 phosphorylation site [posttranslational modification] 436717000774 intermolecular recognition site; other site 436717000775 dimerization interface [polypeptide binding]; other site 436717000776 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 436717000777 DNA binding site [nucleotide binding] 436717000778 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 436717000779 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 436717000780 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 436717000781 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 436717000782 RNA binding site [nucleotide binding]; other site 436717000783 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 436717000784 Sulfate transporter family; Region: Sulfate_transp; pfam00916 436717000785 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 436717000786 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378 436717000787 active site clefts [active] 436717000788 zinc binding site [ion binding]; other site 436717000789 dimer interface [polypeptide binding]; other site 436717000790 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 436717000791 classical (c) SDRs; Region: SDR_c; cd05233 436717000792 NAD(P) binding site [chemical binding]; other site 436717000793 active site 436717000794 Uncharacterized protein family (UPF0093); Region: UPF0093; cl00863 436717000795 Domain of unknown function (DUF3817); Region: DUF3817; pfam12823 436717000796 transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393 436717000797 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 436717000798 conserved cys residue [active] 436717000799 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 436717000800 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 436717000801 O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK06084 436717000802 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 436717000803 homodimer interface [polypeptide binding]; other site 436717000804 substrate-cofactor binding pocket; other site 436717000805 pyridoxal 5'-phosphate binding site [chemical binding]; other site 436717000806 catalytic residue [active] 436717000807 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 436717000808 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 436717000809 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 436717000810 ABC transporter; Region: ABC_tran_2; pfam12848 436717000811 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 436717000812 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 436717000813 Sel1-like repeats; Region: SEL1; smart00671 436717000814 hypothetical protein; Provisional; Region: PRK10215 436717000815 Outer membrane efflux protein; Region: OEP; pfam02321 436717000816 Outer membrane efflux protein; Region: OEP; pfam02321 436717000817 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 436717000818 Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999 436717000819 HlyD family secretion protein; Region: HlyD_3; pfam13437 436717000820 heavy metal efflux pump, CzcA family; Region: 2A0601; TIGR00914 436717000821 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 436717000822 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 436717000823 PGAP1-like protein; Region: PGAP1; pfam07819 436717000824 S-methylmethionine transporter; Provisional; Region: PRK11387 436717000825 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 436717000826 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 436717000827 active site 436717000828 HIGH motif; other site 436717000829 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 436717000830 active site 436717000831 KMSKS motif; other site 436717000832 ABC-type sulfate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: Sbp; COG1613 436717000833 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 436717000834 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 436717000835 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 436717000836 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 436717000837 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 436717000838 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 436717000839 MraW methylase family; Region: Methyltransf_5; cl17771 436717000840 Cell division protein FtsL; Region: FtsL; pfam04999 436717000841 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 436717000842 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 436717000843 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 436717000844 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 436717000845 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 436717000846 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 436717000847 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 436717000848 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 436717000849 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 436717000850 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 436717000851 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 436717000852 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 436717000853 Mg++ binding site [ion binding]; other site 436717000854 putative catalytic motif [active] 436717000855 putative substrate binding site [chemical binding]; other site 436717000856 23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088 436717000857 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 436717000858 S-adenosylmethionine binding site [chemical binding]; other site 436717000859 penicillin-binding protein 1a; Provisional; Region: mrcA; PRK11636 436717000860 Transglycosylase; Region: Transgly; pfam00912 436717000861 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 436717000862 Competence protein A; Region: Competence_A; pfam11104 436717000863 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 436717000864 Tfp pilus assembly protein PilN [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilN; COG3166 436717000865 Fimbrial assembly protein (PilN); Region: PilN; pfam05137 436717000866 Pilus assembly protein, PilO; Region: PilO; pfam04350 436717000867 Tfp pilus assembly protein PilP [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilP; COG3168 436717000868 Pilus assembly protein, PilP; Region: PilP; pfam04351 436717000869 type IV pilus secretin (or competence protein) PilQ; Region: IV_pilus_PilQ; TIGR02515 436717000870 Secretin and TonB N terminus short domain; Region: STN; smart00965 436717000871 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 436717000872 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 436717000873 shikimate kinase; Reviewed; Region: aroK; PRK00131 436717000874 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 436717000875 ADP binding site [chemical binding]; other site 436717000876 magnesium binding site [ion binding]; other site 436717000877 putative shikimate binding site; other site 436717000878 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 436717000879 active site 436717000880 dimer interface [polypeptide binding]; other site 436717000881 metal binding site [ion binding]; metal-binding site 436717000882 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 436717000883 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 436717000884 active site 436717000885 dimer interface [polypeptide binding]; other site 436717000886 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 436717000887 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 436717000888 active site 436717000889 FMN binding site [chemical binding]; other site 436717000890 substrate binding site [chemical binding]; other site 436717000891 3Fe-4S cluster binding site [ion binding]; other site 436717000892 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 436717000893 domain interface; other site 436717000894 glutamate synthase small subunit family protein, proteobacterial; Region: gltD_gamma_fam; TIGR01318 436717000895 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 436717000896 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 436717000897 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687 436717000898 Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118 436717000899 LemA family; Region: LemA; pfam04011 436717000900 Repair protein; Region: Repair_PSII; pfam04536 436717000901 Repair protein; Region: Repair_PSII; pfam04536 436717000902 Tfp pilus assembly protein, major pilin PilA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilA; COG4969 436717000903 Pilin (bacterial filament); Region: Pilin; pfam00114 436717000904 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 436717000905 O-Antigen ligase; Region: Wzy_C; pfam04932 436717000906 Domain of unknown function (DUF3366); Region: DUF3366; pfam11846 436717000907 Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193 436717000908 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 436717000909 heme binding site [chemical binding]; other site 436717000910 ferroxidase pore; other site 436717000911 ferroxidase diiron center [ion binding]; other site 436717000912 Bacterioferritin-associated ferredoxin [Inorganic ion transport and metabolism]; Region: Bfd; COG2906 436717000913 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 436717000914 homotrimer interaction site [polypeptide binding]; other site 436717000915 putative active site [active] 436717000916 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 436717000917 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 436717000918 Zn2+ binding site [ion binding]; other site 436717000919 Mg2+ binding site [ion binding]; other site 436717000920 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 436717000921 synthetase active site [active] 436717000922 NTP binding site [chemical binding]; other site 436717000923 metal binding site [ion binding]; metal-binding site 436717000924 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 436717000925 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 436717000926 ACT domain; Region: ACT_4; pfam13291 436717000927 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 436717000928 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 436717000929 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 436717000930 catalytic site [active] 436717000931 G-X2-G-X-G-K; other site 436717000932 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 436717000933 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 436717000934 Tfp pilus assembly protein FimT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimT; COG4970 436717000935 type IV pilus modification protein PilV; Region: type_IV_pilV; TIGR02523 436717000936 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 436717000937 Type IV pilus assembly protein PilX C-term; Region: PilX; pfam13681 436717000938 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 436717000939 metal ion-dependent adhesion site (MIDAS); other site 436717000940 Neisseria PilC beta-propeller domain; Region: Neisseria_PilC; pfam05567 436717000941 Tfp pilus assembly protein PilE [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilE; COG4968 436717000942 Tfp pilus assembly protein PilE [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilE; COG4968 436717000943 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 436717000944 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 436717000945 RimM N-terminal domain; Region: RimM; pfam01782 436717000946 PRC-barrel domain; Region: PRC; pfam05239 436717000947 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 436717000948 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 436717000949 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 436717000950 Putative serine esterase (DUF676); Region: DUF676; pfam05057 436717000951 lipase chaperone; Provisional; Region: PRK01294 436717000952 Proteobacterial lipase chaperone protein; Region: Lipase_chap; pfam03280 436717000953 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05033 436717000954 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 436717000955 RNA binding site [nucleotide binding]; other site 436717000956 active site 436717000957 Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157 436717000958 hypothetical protein; Provisional; Region: PRK10621 436717000959 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 436717000960 Hemerythrin-like domain; Region: Hr-like; cd12108 436717000961 Threonine/homoserine efflux transporter [Amino acid transport and metabolism]; Region: rhtA; COG5006 436717000962 threonine and homoserine efflux system; Provisional; Region: PRK10532 436717000963 EamA-like transporter family; Region: EamA; pfam00892 436717000964 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790 436717000965 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_3; cd12176 436717000966 ligand binding site [chemical binding]; other site 436717000967 NAD binding site [chemical binding]; other site 436717000968 tetramer interface [polypeptide binding]; other site 436717000969 catalytic site [active] 436717000970 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 436717000971 L-serine binding site [chemical binding]; other site 436717000972 ACT domain interface; other site 436717000973 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 436717000974 FAD binding domain; Region: FAD_binding_4; pfam01565 436717000975 Uncharacterized conserved protein [Function unknown]; Region: COG1359 436717000976 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 436717000977 Beta-propeller domains of methanol dehydrogenase type [General function prediction only]; Region: COG1512 436717000978 multidrug efflux system translocase MdfA; Provisional; Region: PRK15402 436717000979 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 436717000980 putative substrate translocation pore; other site 436717000981 FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805 436717000982 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 436717000983 Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032 436717000984 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 436717000985 E-class dimer interface [polypeptide binding]; other site 436717000986 P-class dimer interface [polypeptide binding]; other site 436717000987 active site 436717000988 Cu2+ binding site [ion binding]; other site 436717000989 Zn2+ binding site [ion binding]; other site 436717000990 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 436717000991 Domain of unknown function DUF20; Region: UPF0118; pfam01594 436717000992 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 436717000993 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 436717000994 P-loop; other site 436717000995 Magnesium ion binding site [ion binding]; other site 436717000996 Endonuclease related to archaeal Holliday junction resolvase; Region: Endonuc_Holl; pfam10107 436717000997 Methyltransferase domain; Region: Methyltransf_23; pfam13489 436717000998 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 436717000999 S-adenosylmethionine binding site [chemical binding]; other site 436717001000 S-methylmethionine transporter; Provisional; Region: PRK11387 436717001001 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 436717001002 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 436717001003 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 436717001004 NAD(P) binding site [chemical binding]; other site 436717001005 bifunctional succinylornithine transaminase/acetylornithine transaminase; Provisional; Region: PRK12381 436717001006 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 436717001007 inhibitor-cofactor binding pocket; inhibition site 436717001008 pyridoxal 5'-phosphate binding site [chemical binding]; other site 436717001009 catalytic residue [active] 436717001010 Arginine N-succinyltransferase beta subunit; Region: AstA; cl11440 436717001011 Arginine/ornithine N-succinyltransferase beta subunit [Amino acid transport and metabolism]; Region: AstA; COG3138 436717001012 succinylglutamic semialdehyde dehydrogenase; Reviewed; Region: astD; PRK09457 436717001013 N-succinylglutamate 5-semialdehyde dehydrogenase, AstD-like; Region: ALDH_SGSD_AstD; cd07095 436717001014 NAD(P) binding site [chemical binding]; other site 436717001015 catalytic residues [active] 436717001016 succinylarginine dihydrolase; Provisional; Region: PRK13281 436717001017 Peptidase M14 Succinylglutamate desuccinylase (ASTE) subfamily; Region: M14_ASTE; cd03855 436717001018 Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952 436717001019 putative active site [active] 436717001020 Zn binding site [ion binding]; other site 436717001021 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 436717001022 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 436717001023 active site 436717001024 catalytic residues [active] 436717001025 Transcriptional regulator [Transcription]; Region: LysR; COG0583 436717001026 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 436717001027 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 436717001028 dimerization interface [polypeptide binding]; other site 436717001029 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 436717001030 EamA-like transporter family; Region: EamA; pfam00892 436717001031 EamA-like transporter family; Region: EamA; pfam00892 436717001032 YCII-related domain; Region: YCII; cl00999 436717001033 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 436717001034 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 436717001035 dimer interface [polypeptide binding]; other site 436717001036 motif 1; other site 436717001037 active site 436717001038 motif 2; other site 436717001039 motif 3; other site 436717001040 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 436717001041 Sel1-like repeats; Region: SEL1; smart00671 436717001042 Sel1 repeat; Region: Sel1; cl02723 436717001043 Protein of unknown function (DUF1311); Region: DUF1311; pfam07007 436717001044 putative DNA modification/repair radical SAM protein; Region: rSAM_link_UDG; TIGR03916 436717001045 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 436717001046 FeS/SAM binding site; other site 436717001047 probable DNA metabolism protein; Region: SAM_7_link_chp; TIGR03915 436717001048 CBS-domain-containing membrane protein [Signal transduction mechanisms]; Region: COG3448 436717001049 HPP family; Region: HPP; pfam04982 436717001050 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the HPP motif domain. These proteins are integral membrane proteins with four transmembrane spanning helices. The function of these proteins is...; Region: CBS_pair_HPP_assoc; cd04600 436717001051 PspC domain; Region: PspC; pfam04024 436717001052 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 436717001053 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 436717001054 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 436717001055 active site 436717001056 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 436717001057 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 436717001058 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 436717001059 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 436717001060 shikimate binding site; other site 436717001061 NAD(P) binding site [chemical binding]; other site 436717001062 coproporphyrinogen III oxidase; Provisional; Region: PRK05330 436717001063 Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; pfam01218 436717001064 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 436717001065 dimerization interface [polypeptide binding]; other site 436717001066 active site 436717001067 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 436717001068 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 436717001069 TPP-binding site; other site 436717001070 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 436717001071 PYR/PP interface [polypeptide binding]; other site 436717001072 dimer interface [polypeptide binding]; other site 436717001073 TPP binding site [chemical binding]; other site 436717001074 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 436717001075 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 436717001076 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 436717001077 active site 436717001078 dimerization interface [polypeptide binding]; other site 436717001079 ATP-dependent RNA helicase RhlB; Provisional; Region: PRK04837 436717001080 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 436717001081 ATP binding site [chemical binding]; other site 436717001082 Mg++ binding site [ion binding]; other site 436717001083 motif III; other site 436717001084 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 436717001085 nucleotide binding region [chemical binding]; other site 436717001086 ATP-binding site [chemical binding]; other site 436717001087 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 436717001088 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 436717001089 Walker A/P-loop; other site 436717001090 ATP binding site [chemical binding]; other site 436717001091 Q-loop/lid; other site 436717001092 ABC transporter signature motif; other site 436717001093 Walker B; other site 436717001094 D-loop; other site 436717001095 H-loop/switch region; other site 436717001096 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 436717001097 Permease; Region: Permease; cl00510 436717001098 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 436717001099 mce related protein; Region: MCE; pfam02470 436717001100 Toluene tolerance, Ttg2; Region: Tol_Tol_Ttg2; pfam05494 436717001101 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 436717001102 anti sigma factor interaction site; other site 436717001103 regulatory phosphorylation site [posttranslational modification]; other site 436717001104 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 436717001105 metal ion transporter CorA-like divalent cation transporter superfamily; Region: MIT_CorA-like; cl00459 436717001106 oligomer interface [polypeptide binding]; other site 436717001107 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 436717001108 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_31; cd04690 436717001109 nudix motif; other site 436717001110 comF family protein; Region: comF; TIGR00201 436717001111 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 436717001112 active site 436717001113 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 436717001114 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 436717001115 ssDNA binding site; other site 436717001116 generic binding surface II; other site 436717001117 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 436717001118 ATP binding site [chemical binding]; other site 436717001119 putative Mg++ binding site [ion binding]; other site 436717001120 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 436717001121 nucleotide binding region [chemical binding]; other site 436717001122 ATP-binding site [chemical binding]; other site 436717001123 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 436717001124 NADH(P)-binding; Region: NAD_binding_10; pfam13460 436717001125 NAD(P) binding site [chemical binding]; other site 436717001126 active site 436717001127 NMT1/THI5 like; Region: NMT1; pfam09084 436717001128 potential frameshift: common BLAST hit: gi|169632340|ref|YP_001706076.1| glycerol-3-phosphate acyltransferase 436717001129 Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946 436717001130 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 436717001131 active site 436717001132 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 436717001133 catalytic triad [active] 436717001134 dimer interface [polypeptide binding]; other site 436717001135 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 436717001136 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 436717001137 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687 436717001138 Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118 436717001139 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 436717001140 G1 box; other site 436717001141 GTP/Mg2+ binding site [chemical binding]; other site 436717001142 Switch I region; other site 436717001143 G2 box; other site 436717001144 G3 box; other site 436717001145 Switch II region; other site 436717001146 G4 box; other site 436717001147 G5 box; other site 436717001148 Transcriptional regulator; Region: Rrf2; cl17282 436717001149 Rrf2 family protein; Region: rrf2_super; TIGR00738 436717001150 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 436717001151 heme-binding site [chemical binding]; other site 436717001152 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 436717001153 FAD binding pocket [chemical binding]; other site 436717001154 conserved FAD binding motif [chemical binding]; other site 436717001155 phosphate binding motif [ion binding]; other site 436717001156 Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872 436717001157 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 436717001158 Walker A motif; other site 436717001159 ATP binding site [chemical binding]; other site 436717001160 Walker B motif; other site 436717001161 Zonular occludens toxin (Zot); Region: Zot; cl17485 436717001162 cystathionine beta-lyase; Provisional; Region: PRK07050 436717001163 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 436717001164 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 436717001165 catalytic residue [active] 436717001166 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 436717001167 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 436717001168 catalytic triad [active] 436717001169 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 436717001170 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 436717001171 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 436717001172 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 436717001173 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 436717001174 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 436717001175 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 436717001176 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 436717001177 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 436717001178 putative translocon binding site; other site 436717001179 protein-rRNA interface [nucleotide binding]; other site 436717001180 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 436717001181 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 436717001182 G-X-X-G motif; other site 436717001183 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 436717001184 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 436717001185 23S rRNA interface [nucleotide binding]; other site 436717001186 5S rRNA interface [nucleotide binding]; other site 436717001187 putative antibiotic binding site [chemical binding]; other site 436717001188 L25 interface [polypeptide binding]; other site 436717001189 L27 interface [polypeptide binding]; other site 436717001190 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 436717001191 23S rRNA interface [nucleotide binding]; other site 436717001192 putative translocon interaction site; other site 436717001193 signal recognition particle (SRP54) interaction site; other site 436717001194 L23 interface [polypeptide binding]; other site 436717001195 trigger factor interaction site; other site 436717001196 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 436717001197 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 436717001198 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 436717001199 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 436717001200 RNA binding site [nucleotide binding]; other site 436717001201 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 436717001202 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 436717001203 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 436717001204 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 436717001205 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 436717001206 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 436717001207 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 436717001208 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 436717001209 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 436717001210 5S rRNA interface [nucleotide binding]; other site 436717001211 23S rRNA interface [nucleotide binding]; other site 436717001212 L5 interface [polypeptide binding]; other site 436717001213 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 436717001214 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 436717001215 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 436717001216 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 436717001217 23S rRNA binding site [nucleotide binding]; other site 436717001218 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 436717001219 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 436717001220 SecY translocase; Region: SecY; pfam00344 436717001221 Ribosomal protein L36; Region: Ribosomal_L36; pfam00444 436717001222 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 436717001223 30S ribosomal protein S13; Region: bact_S13; TIGR03631 436717001224 30S ribosomal protein S11; Validated; Region: PRK05309 436717001225 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 436717001226 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 436717001227 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 436717001228 RNA binding surface [nucleotide binding]; other site 436717001229 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 436717001230 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 436717001231 alphaNTD homodimer interface [polypeptide binding]; other site 436717001232 alphaNTD - beta interaction site [polypeptide binding]; other site 436717001233 alphaNTD - beta' interaction site [polypeptide binding]; other site 436717001234 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 436717001235 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 436717001236 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 436717001237 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 436717001238 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 436717001239 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 436717001240 active site 436717001241 Flavinator of succinate dehydrogenase; Region: Sdh5; pfam03937 436717001242 rhomboid family GlyGly-CTERM serine protease; Region: rhom_GG_sort; TIGR03902 436717001243 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274 436717001244 Probable metal-binding protein (DUF2387); Region: DUF2387; pfam09526 436717001245 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 436717001246 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 436717001247 active site 436717001248 Zn binding site [ion binding]; other site 436717001249 ribonuclease R; Region: RNase_R; TIGR02063 436717001250 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 436717001251 RNB domain; Region: RNB; pfam00773 436717001252 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 436717001253 RNA binding site [nucleotide binding]; other site 436717001254 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 436717001255 Nitroreductase-like family 4. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_4; cd02140 436717001256 dimer interface [polypeptide binding]; other site 436717001257 FMN binding site [chemical binding]; other site 436717001258 YcxB-like protein; Region: YcxB; pfam14317 436717001259 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 436717001260 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 436717001261 ribonuclease BN/unknown domain fusion protein; Reviewed; Region: rbn; PRK04214 436717001262 Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918 436717001263 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 436717001264 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 436717001265 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 436717001266 active site 436717001267 Protein of unknown function (DUF3108); Region: DUF3108; pfam11306 436717001268 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 436717001269 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 436717001270 metal-binding heat shock protein; Provisional; Region: PRK00016 436717001271 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 436717001272 PhoH-like protein; Region: PhoH; pfam02562 436717001273 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325 436717001274 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 436717001275 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 436717001276 FeS/SAM binding site; other site 436717001277 TRAM domain; Region: TRAM; pfam01938 436717001278 lytic murein transglycosylase; Provisional; Region: PRK11619 436717001279 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 436717001280 N-acetyl-D-glucosamine binding site [chemical binding]; other site 436717001281 catalytic residue [active] 436717001282 Ribonuclease T2 (RNase T2) is a widespread family of secreted RNases found in every organism examined thus far. This family includes RNase Rh, RNase MC1, RNase LE, and self-incompatibility RNases (S-RNases). Plant T2 RNases are expressed during leaf...; Region: RNase_T2_prok; cd01062 436717001283 B1 nucleotide binding pocket [chemical binding]; other site 436717001284 B2 nucleotide binding pocket [chemical binding]; other site 436717001285 CAS motifs; other site 436717001286 active site 436717001287 malate dehydrogenase; Provisional; Region: PRK05442 436717001288 Chloroplast-like malate dehydrogenases; Region: MDH_choloroplast_like; cd01338 436717001289 NAD(P) binding site [chemical binding]; other site 436717001290 dimer interface [polypeptide binding]; other site 436717001291 malate binding site [chemical binding]; other site 436717001292 Protein of unknown function (DUF2789); Region: DUF2789; pfam10982 436717001293 Predicted proline hydroxylase [Posttranslational modification, protein turnover, chaperones]; Region: EGL-9; COG3751 436717001294 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; pfam13640 436717001295 Protein involved in catabolism of external DNA [General function prediction only]; Region: ComJ; COG2961 436717001296 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 436717001297 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 436717001298 Uncharacterized conserved protein [Function unknown]; Region: COG3791 436717001299 Protein of unknown function (DUF4256); Region: DUF4256; pfam14066 436717001300 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 436717001301 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 436717001302 active site 436717001303 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 436717001304 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 436717001305 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 436717001306 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 436717001307 Protein of unknown function (DUF1446); Region: DUF1446; pfam07287 436717001308 Trans-2-enoyl-CoA reductase (TER) and 2,4-dienoyl-CoA reductase (DECR), atypical (a) SDR; Region: TER_DECR_SDR_a; cd05369 436717001309 NAD(P) binding site [chemical binding]; other site 436717001310 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 436717001311 substrate binding site [chemical binding]; other site 436717001312 homotetramer interface [polypeptide binding]; other site 436717001313 active site 436717001314 homodimer interface [polypeptide binding]; other site 436717001315 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 436717001316 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 436717001317 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 436717001318 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 436717001319 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 436717001320 active site 436717001321 enoyl-CoA hydratase; Provisional; Region: PRK05995 436717001322 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 436717001323 substrate binding site [chemical binding]; other site 436717001324 oxyanion hole (OAH) forming residues; other site 436717001325 trimer interface [polypeptide binding]; other site 436717001326 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 436717001327 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 436717001328 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 436717001329 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785 436717001330 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 436717001331 carboxyltransferase (CT) interaction site; other site 436717001332 biotinylation site [posttranslational modification]; other site 436717001333 Roadblock/LC7 domain; Region: Robl_LC7; smart00960 436717001334 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 436717001335 G1 box; other site 436717001336 GTP/Mg2+ binding site [chemical binding]; other site 436717001337 G2 box; other site 436717001338 Switch I region; other site 436717001339 G3 box; other site 436717001340 Switch II region; other site 436717001341 G4 box; other site 436717001342 G5 box; other site 436717001343 ClpXP protease specificity-enhancing factor; Provisional; Region: PRK11798 436717001344 stringent starvation protein A; Provisional; Region: sspA; PRK09481 436717001345 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 436717001346 C-terminal, alpha helical domain of Stringent starvation protein A; Region: GST_C_SspA; cd03186 436717001347 dimer interface [polypeptide binding]; other site 436717001348 N-terminal domain interface [polypeptide binding]; other site 436717001349 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 436717001350 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 436717001351 23S rRNA interface [nucleotide binding]; other site 436717001352 L3 interface [polypeptide binding]; other site 436717001353 4-hydroxythreonine-4-phosphate dehydrogenase; Region: pdxA; TIGR00557 436717001354 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 436717001355 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 436717001356 Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030 436717001357 diadenosine tetraphosphatase; Reviewed; Region: apaH; PRK00166 436717001358 Escherichia coli ApaH and related proteins, metallophosphatase domain; Region: MPP_ApaH; cd07422 436717001359 active site 436717001360 metal binding site [ion binding]; metal-binding site 436717001361 Uncharacterized protein conserved in bacteria (DUF2147); Region: DUF2147; pfam09917 436717001362 LrgB-like family; Region: LrgB; cl00596 436717001363 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 436717001364 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 436717001365 HflX GTPase family; Region: HflX; cd01878 436717001366 G1 box; other site 436717001367 GTP/Mg2+ binding site [chemical binding]; other site 436717001368 Switch I region; other site 436717001369 G2 box; other site 436717001370 G3 box; other site 436717001371 Switch II region; other site 436717001372 G4 box; other site 436717001373 G5 box; other site 436717001374 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 436717001375 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 436717001376 putative acyl-acceptor binding pocket; other site 436717001377 Putative catalytic domain, repeat 1, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_1; cd09111 436717001378 putative active site [active] 436717001379 catalytic site [active] 436717001380 Putative catalytic domain, repeat 2, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_2; cd09113 436717001381 PLD-like domain; Region: PLDc_2; pfam13091 436717001382 putative active site [active] 436717001383 catalytic site [active] 436717001384 phosphodiesterase YaeI; Provisional; Region: PRK11340 436717001385 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 436717001386 putative active site [active] 436717001387 putative metal binding site [ion binding]; other site 436717001388 putative outer membrane lipoprotein; Provisional; Region: PRK09967 436717001389 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 436717001390 ligand binding site [chemical binding]; other site 436717001391 putative inner membrane diguanylate cyclase; Provisional; Region: PRK09966 436717001392 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 436717001393 metal binding site [ion binding]; metal-binding site 436717001394 active site 436717001395 I-site; other site 436717001396 Domain of unknown function (DUF4154); Region: DUF4154; pfam13689 436717001397 dihydrolipoamide dehydrogenase; Validated; Region: PRK06292 436717001398 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 436717001399 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 436717001400 Putative phosphatase (DUF442); Region: DUF442; cl17385 436717001401 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 436717001402 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 436717001403 thioredoxin 2; Provisional; Region: PRK10996 436717001404 zinc-ribbon domain; Region: zinc_ribbon_5; cl11777 436717001405 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 436717001406 catalytic residues [active] 436717001407 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 436717001408 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 436717001409 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 436717001410 CoenzymeA binding site [chemical binding]; other site 436717001411 subunit interaction site [polypeptide binding]; other site 436717001412 PHB binding site; other site 436717001413 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 436717001414 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 436717001415 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 436717001416 active site residue [active] 436717001417 bifunctional tRNA (mnm(5)s(2)U34)-methyltransferase/FAD-dependent cmnm(5)s(2)U34 oxidoreductase; Reviewed; Region: mnmC; PRK01747 436717001418 Uncharacterized conserved protein [Function unknown]; Region: COG4121 436717001419 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 436717001420 YciI-like protein; Reviewed; Region: PRK11370 436717001421 Intracellular septation protein A; Region: IspA; pfam04279 436717001422 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 436717001423 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 436717001424 active site 436717001425 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 436717001426 Bestrophin, RFP-TM, chloride channel; Region: Bestrophin; pfam01062 436717001427 hypothetical protein; Reviewed; Region: PRK00024 436717001428 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 436717001429 MPN+ (JAMM) motif; other site 436717001430 Zinc-binding site [ion binding]; other site 436717001431 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 436717001432 Flavoprotein; Region: Flavoprotein; pfam02441 436717001433 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 436717001434 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 436717001435 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 436717001436 Protein export membrane protein; Region: SecD_SecF; pfam02355 436717001437 SecD export protein N-terminal TM region; Region: SecD-TM1; pfam13721 436717001438 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 436717001439 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 436717001440 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 436717001441 preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585 436717001442 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 436717001443 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 436717001444 LemA family; Region: LemA; cl00742 436717001445 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 436717001446 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 436717001447 Protein of unknown function (DUF2939); Region: DUF2939; pfam11159 436717001448 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 436717001449 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 436717001450 dimer interface [polypeptide binding]; other site 436717001451 phosphorylation site [posttranslational modification] 436717001452 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 436717001453 ATP binding site [chemical binding]; other site 436717001454 Mg2+ binding site [ion binding]; other site 436717001455 G-X-G motif; other site 436717001456 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Reviewed; Region: PRK11072 436717001457 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 436717001458 metal binding triad; other site 436717001459 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 436717001460 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 436717001461 metal binding triad; other site 436717001462 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 436717001463 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 436717001464 homodimer interface [polypeptide binding]; other site 436717001465 substrate-cofactor binding pocket; other site 436717001466 catalytic residue [active] 436717001467 Predicted nucleoside-diphosphate-sugar epimerase [Cell envelope biogenesis, outer membrane]; Region: COG3660 436717001468 Mitochondrial fission ELM1; Region: Mito_fiss_Elm1; pfam06258 436717001469 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 436717001470 phosphorylation site [posttranslational modification] 436717001471 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 436717001472 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 436717001473 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 436717001474 putative active site [active] 436717001475 putative metal binding site [ion binding]; other site 436717001476 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 436717001477 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 436717001478 putative metal binding site; other site 436717001479 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 436717001480 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 436717001481 putative ADP-binding pocket [chemical binding]; other site 436717001482 Glycosyltransferase family 25 [lipooligosaccharide (LOS) biosynthesis protein] is a family of glycosyltransferases involved in LOS biosynthesis. The members include the beta(1,4) galactosyltransferases: Lgt2 of Moraxella catarrhalis, LgtB and LgtE of...; Region: Glyco_transf_25; cd06532 436717001483 Protein of unknown function (DUF3184); Region: DUF3184; pfam11380 436717001484 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 436717001485 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 436717001486 dimer interface [polypeptide binding]; other site 436717001487 anticodon binding site; other site 436717001488 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 436717001489 homodimer interface [polypeptide binding]; other site 436717001490 motif 1; other site 436717001491 active site 436717001492 motif 2; other site 436717001493 GAD domain; Region: GAD; pfam02938 436717001494 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 436717001495 active site 436717001496 motif 3; other site 436717001497 Domain of unknown function (DUF4184); Region: DUF4184; pfam13803 436717001498 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 436717001499 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 436717001500 N-terminal plug; other site 436717001501 ligand-binding site [chemical binding]; other site 436717001502 Putative catalytic domain, repeat 1, of uncharacterized phospholipase D-like proteins; Region: PLDc_unchar2_1; cd09129 436717001503 putative active site [active] 436717001504 putative catalytic site [active] 436717001505 Putative catalytic domain, repeat 2, of uncharacterized phospholipase D-like proteins; Region: PLDc_unchar2_2; cd09130 436717001506 PLD-like domain; Region: PLDc_2; pfam13091 436717001507 putative active site [active] 436717001508 putative catalytic site [active] 436717001509 Domain of unknown function (DUF3315); Region: DUF3315; pfam11776 436717001510 Predicted membrane protein [Function unknown]; Region: COG3223 436717001511 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 436717001512 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 436717001513 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 436717001514 active site 436717001515 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 436717001516 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 436717001517 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 436717001518 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 436717001519 active site 436717001520 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 436717001521 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 436717001522 dimerization interface [polypeptide binding]; other site 436717001523 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 436717001524 dimer interface [polypeptide binding]; other site 436717001525 phosphorylation site [posttranslational modification] 436717001526 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 436717001527 ATP binding site [chemical binding]; other site 436717001528 Mg2+ binding site [ion binding]; other site 436717001529 G-X-G motif; other site 436717001530 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 436717001531 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 436717001532 active site 436717001533 phosphorylation site [posttranslational modification] 436717001534 intermolecular recognition site; other site 436717001535 dimerization interface [polypeptide binding]; other site 436717001536 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 436717001537 DNA binding site [nucleotide binding] 436717001538 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 436717001539 Uncharacterized conserved protein [Function unknown]; Region: COG0397 436717001540 hypothetical protein; Validated; Region: PRK00029 436717001541 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 436717001542 Fatty acid desaturase; Region: FA_desaturase; pfam00487 436717001543 Di-iron ligands [ion binding]; other site 436717001544 META domain; Region: META; pfam03724 436717001545 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 436717001546 Glycerophosphodiester phosphodiesterase domain as found in prokaryota and eukaryota, and similar proteins; Region: GDPD; cd08556 436717001547 active site 436717001548 catalytic site [active] 436717001549 metal binding site [ion binding]; metal-binding site 436717001550 Cobalamin adenosyltransferase; Region: Cob_adeno_trans; pfam01923 436717001551 Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206 436717001552 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 436717001553 N-terminal plug; other site 436717001554 ligand-binding site [chemical binding]; other site 436717001555 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 436717001556 active site 436717001557 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 436717001558 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 436717001559 pyridoxal 5'-phosphate binding site [chemical binding]; other site 436717001560 catalytic residue [active] 436717001561 Domain of Unknown Function (DUF1543); Region: DUF1543; pfam07566 436717001562 Protein of unknown function (DUF2804); Region: DUF2804; pfam10974 436717001563 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687 436717001564 Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118 436717001565 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 436717001566 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 436717001567 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 436717001568 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 436717001569 substrate binding site [chemical binding]; other site 436717001570 active site 436717001571 catalytic residues [active] 436717001572 heterodimer interface [polypeptide binding]; other site 436717001573 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 436717001574 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 436717001575 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 436717001576 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 436717001577 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 436717001578 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 436717001579 active site 436717001580 catalytic residues [active] 436717001581 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 436717001582 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 436717001583 Peroxiredoxin (PRX) family, 1-cys PRX subfamily; composed of PRXs containing only one conserved cysteine, which serves as the peroxidatic cysteine. They are homodimeric thiol-specific antioxidant (TSA) proteins that confer a protective role in cells by...; Region: PRX_1cys; cd03016 436717001584 dimer interface [polypeptide binding]; other site 436717001585 decamer (pentamer of dimers) interface [polypeptide binding]; other site 436717001586 catalytic triad [active] 436717001587 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 436717001588 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 436717001589 SEC-C motif; Region: SEC-C; pfam02810 436717001590 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 436717001591 metabolite-proton symporter; Region: 2A0106; TIGR00883 436717001592 putative substrate translocation pore; other site 436717001593 Haemolysin-III related; Region: HlyIII; cl03831 436717001594 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 436717001595 Methyltransferase domain; Region: Methyltransf_31; pfam13847 436717001596 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 436717001597 S-adenosylmethionine binding site [chemical binding]; other site 436717001598 Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; cl17496 436717001599 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 436717001600 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 436717001601 Coenzyme A binding pocket [chemical binding]; other site 436717001602 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667 436717001603 Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208 436717001604 active site 436717001605 nucleophile elbow; other site 436717001606 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 436717001607 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 436717001608 substrate binding site [chemical binding]; other site 436717001609 oxyanion hole (OAH) forming residues; other site 436717001610 trimer interface [polypeptide binding]; other site 436717001611 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 436717001612 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 436717001613 acetyl-CoA acetyltransferase; Validated; Region: PRK08242 436717001614 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 436717001615 dimer interface [polypeptide binding]; other site 436717001616 active site 436717001617 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 436717001618 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 436717001619 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 436717001620 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 436717001621 CoA-transferase family III; Region: CoA_transf_3; pfam02515 436717001622 Carbohydrate-selective porin, OprB family; Region: OprB; cl17816 436717001623 membrane-bound PQQ-dependent dehydrogenase, glucose/quinate/shikimate family; Region: PQQ_membr_DH; TIGR03074 436717001624 Membrane-bound PQQ-dependent glucose dehydrogenase; Region: PQQ_mGDH; cd10280 436717001625 Trp docking motif [polypeptide binding]; other site 436717001626 putative active site [active] 436717001627 Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155 436717001628 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 436717001629 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 436717001630 Bacterial protein of unknown function (DUF934); Region: DUF934; pfam06073 436717001631 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 436717001632 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 436717001633 dimer interface [polypeptide binding]; other site 436717001634 acetyl-CoA acetyltransferase; Provisional; Region: PRK06954 436717001635 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 436717001636 dimer interface [polypeptide binding]; other site 436717001637 active site 436717001638 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830 436717001639 Type II transport protein GspH; Region: GspH; pfam12019 436717001640 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 436717001641 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 436717001642 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 436717001643 ligand binding site [chemical binding]; other site 436717001644 Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139 436717001645 hypothetical protein; Reviewed; Region: PRK09588 436717001646 lysine transporter; Provisional; Region: PRK10836 436717001647 16S ribosomal RNA m2G1207 methyltransferase; Provisional; Region: rsmC; PRK09489 436717001648 Methyltransferase small domain N-terminal; Region: MTS_N; pfam08468 436717001649 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 436717001650 S-adenosylmethionine binding site [chemical binding]; other site 436717001651 Xanthine/uracil permeases [Nucleotide transport and metabolism]; Region: UraA; COG2233 436717001652 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 436717001653 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 436717001654 G1 box; other site 436717001655 putative GEF interaction site [polypeptide binding]; other site 436717001656 GTP/Mg2+ binding site [chemical binding]; other site 436717001657 Switch I region; other site 436717001658 G2 box; other site 436717001659 G3 box; other site 436717001660 Switch II region; other site 436717001661 G4 box; other site 436717001662 G5 box; other site 436717001663 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 436717001664 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 436717001665 large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13952 436717001666 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 436717001667 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 436717001668 putative active site pocket [active] 436717001669 dimerization interface [polypeptide binding]; other site 436717001670 putative catalytic residue [active] 436717001671 PPIC-type PPIASE domain; Region: Rotamase_2; cl08278 436717001672 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 436717001673 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 436717001674 DNA binding site [nucleotide binding] 436717001675 catalytic residue [active] 436717001676 H2TH interface [polypeptide binding]; other site 436717001677 putative catalytic residues [active] 436717001678 turnover-facilitating residue; other site 436717001679 intercalation triad [nucleotide binding]; other site 436717001680 8OG recognition residue [nucleotide binding]; other site 436717001681 putative reading head residues; other site 436717001682 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 436717001683 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 436717001684 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 436717001685 active site 436717001686 DNA binding site [nucleotide binding] 436717001687 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 436717001688 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 436717001689 N-terminal plug; other site 436717001690 ligand-binding site [chemical binding]; other site 436717001691 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 436717001692 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 436717001693 active site 436717001694 FMN binding site [chemical binding]; other site 436717001695 substrate binding site [chemical binding]; other site 436717001696 homotetramer interface [polypeptide binding]; other site 436717001697 catalytic residue [active] 436717001698 Predicted permeases [General function prediction only]; Region: COG0679 436717001699 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 436717001700 Sel1-like repeats; Region: SEL1; smart00671 436717001701 protein disulfide isomerase II DsbC; Provisional; Region: PRK10877 436717001702 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020 436717001703 dimerization domain [polypeptide binding]; other site 436717001704 dimer interface [polypeptide binding]; other site 436717001705 catalytic residues [active] 436717001706 Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354 436717001707 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 436717001708 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_2; cd08895 436717001709 putative hydrophobic ligand binding site [chemical binding]; other site 436717001710 Uncharacterized conserved protein [Function unknown]; Region: COG3189 436717001711 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 436717001712 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 436717001713 PhnA protein; Region: PhnA; pfam03831 436717001714 Uncharacterized conserved protein [Function unknown]; Region: COG3422 436717001715 Domain of unknown function (DUF1508); Region: DUF1508; pfam07411 436717001716 prolyl-tRNA synthetase; Provisional; Region: PRK09194 436717001717 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 436717001718 dimer interface [polypeptide binding]; other site 436717001719 motif 1; other site 436717001720 active site 436717001721 motif 2; other site 436717001722 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 436717001723 putative deacylase active site [active] 436717001724 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 436717001725 active site 436717001726 motif 3; other site 436717001727 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 436717001728 anticodon binding site; other site 436717001729 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 436717001730 Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999 436717001731 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 436717001732 E3 interaction surface; other site 436717001733 lipoyl attachment site [posttranslational modification]; other site 436717001734 Response regulator receiver domain; Region: Response_reg; pfam00072 436717001735 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 436717001736 active site 436717001737 phosphorylation site [posttranslational modification] 436717001738 intermolecular recognition site; other site 436717001739 dimerization interface [polypeptide binding]; other site 436717001740 Response regulator receiver domain; Region: Response_reg; pfam00072 436717001741 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 436717001742 active site 436717001743 phosphorylation site [posttranslational modification] 436717001744 intermolecular recognition site; other site 436717001745 dimerization interface [polypeptide binding]; other site 436717001746 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 436717001747 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 436717001748 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 436717001749 dimer interface [polypeptide binding]; other site 436717001750 putative CheW interface [polypeptide binding]; other site 436717001751 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086 436717001752 putative binding surface; other site 436717001753 active site 436717001754 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 436717001755 putative binding surface; other site 436717001756 active site 436717001757 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 436717001758 putative binding surface; other site 436717001759 active site 436717001760 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 436717001761 putative binding surface; other site 436717001762 active site 436717001763 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 436717001764 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 436717001765 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 436717001766 ATP binding site [chemical binding]; other site 436717001767 Mg2+ binding site [ion binding]; other site 436717001768 G-X-G motif; other site 436717001769 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 436717001770 Response regulator receiver domain; Region: Response_reg; pfam00072 436717001771 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 436717001772 active site 436717001773 phosphorylation site [posttranslational modification] 436717001774 intermolecular recognition site; other site 436717001775 dimerization interface [polypeptide binding]; other site 436717001776 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009 436717001777 M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891 436717001778 metal binding site [ion binding]; metal-binding site 436717001779 dimer interface [polypeptide binding]; other site 436717001780 Predicted small secreted protein [Function unknown]; Region: COG5510 436717001781 Domain of unknown function (DUF1853); Region: DUF1853; cl01545 436717001782 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2832 436717001783 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 436717001784 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 436717001785 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 436717001786 putative active site [active] 436717001787 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 436717001788 PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172 436717001789 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 436717001790 Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; Region: CysJ; COG0369 436717001791 Flavodoxin; Region: Flavodoxin_1; pfam00258 436717001792 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR_like1; cd06200 436717001793 FAD binding pocket [chemical binding]; other site 436717001794 FAD binding motif [chemical binding]; other site 436717001795 catalytic residues [active] 436717001796 NAD binding pocket [chemical binding]; other site 436717001797 phosphate binding motif [ion binding]; other site 436717001798 beta-alpha-beta structure motif; other site 436717001799 SdpI/YhfL protein family; Region: SdpI; pfam13630 436717001800 TIGR01666 family membrane protein; Region: YCCS 436717001801 FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805 436717001802 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 436717001803 bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102 436717001804 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 436717001805 putative substrate translocation pore; other site 436717001806 Nitroreductase family. Members of this family utilize FMN as a cofactor and catalyze reduction of a variety of nitroaromatic compounds, including nitrofurans, nitrobenzens, nitrophenol, nitrobenzoate and quinones by using either NADH or NADPH as a source...; Region: Nitroreductase; cd02136 436717001807 putative FMN binding site [chemical binding]; other site 436717001808 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 436717001809 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 436717001810 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 436717001811 Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205 436717001812 active site 436717001813 nucleophile elbow; other site 436717001814 threonine dehydratase; Provisional; Region: PRK07334 436717001815 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 436717001816 tetramer interface [polypeptide binding]; other site 436717001817 pyridoxal 5'-phosphate binding site [chemical binding]; other site 436717001818 catalytic residue [active] 436717001819 C-terminal ACT domain of biodegradative (catabolic) threonine dehydratase II (ThrD-II) and other related ACT domains; Region: ACT_ThrD-II-like; cd04886 436717001820 microcin B17 transporter; Reviewed; Region: PRK11098 436717001821 Protein of unknown function (DUF1176); Region: DUF1176; pfam06674 436717001822 intracellular protease, PfpI family; Region: PfpI; TIGR01382 436717001823 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_1; cd03169 436717001824 conserved cys residue [active] 436717001825 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 436717001826 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 436717001827 GatB domain; Region: GatB_Yqey; smart00845 436717001828 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 436717001829 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 436717001830 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 436717001831 rod shape-determining protein MreB; Provisional; Region: PRK13927 436717001832 MreB and similar proteins; Region: MreB_like; cd10225 436717001833 nucleotide binding site [chemical binding]; other site 436717001834 Mg binding site [ion binding]; other site 436717001835 putative protofilament interaction site [polypeptide binding]; other site 436717001836 RodZ interaction site [polypeptide binding]; other site 436717001837 rod shape-determining protein MreC; Provisional; Region: PRK13922 436717001838 rod shape-determining protein MreC; Region: MreC; pfam04085 436717001839 rod shape-determining protein MreD; Region: shape_MreD; TIGR03426 436717001840 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 436717001841 active site 436717001842 dimer interface [polypeptide binding]; other site 436717001843 ribonuclease G; Provisional; Region: PRK11712 436717001844 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 436717001845 homodimer interface [polypeptide binding]; other site 436717001846 oligonucleotide binding site [chemical binding]; other site 436717001847 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 436717001848 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 436717001849 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 436717001850 Active Sites [active] 436717001851 phosphoserine phosphatase; Provisional; Region: thrH; PRK13582 436717001852 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 436717001853 Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; cl17479 436717001854 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 436717001855 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 436717001856 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 436717001857 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 436717001858 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 436717001859 potential frameshift: common BLAST hit: gi|184159340|ref|YP_001847679.1| Fatty acid desaturase 436717001860 PaaX-like protein C-terminal domain; Region: PaaX_C; pfam08223 436717001861 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 436717001862 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 436717001863 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 436717001864 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 436717001865 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 436717001866 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 436717001867 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 436717001868 NAD(P) binding site [chemical binding]; other site 436717001869 chaperone protein HchA; Provisional; Region: PRK04155 436717001870 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 436717001871 conserved cys residue [active] 436717001872 Protein of unknown function (DUF2805); Region: DUF2805; pfam10985 436717001873 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 436717001874 probable AcnD-accessory protein PrpF; Region: prpF; TIGR02334 436717001875 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 436717001876 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 436717001877 substrate binding pocket [chemical binding]; other site 436717001878 chain length determination region; other site 436717001879 substrate-Mg2+ binding site; other site 436717001880 catalytic residues [active] 436717001881 aspartate-rich region 1; other site 436717001882 active site lid residues [active] 436717001883 aspartate-rich region 2; other site 436717001884 Protein of unknown function (DUF419); Region: DUF419; cl15265 436717001885 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 436717001886 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 436717001887 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 436717001888 hypothetical protein; Provisional; Region: PRK10279 436717001889 Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205 436717001890 nucleophile elbow; other site 436717001891 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 436717001892 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown ABO13168; Region: LPLAT_ABO13168-like; cd07988 436717001893 putative acyl-acceptor binding pocket; other site 436717001894 muropeptide transporter; Validated; Region: ampG; cl17669 436717001895 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 436717001896 putative metal dependent hydrolase; Provisional; Region: PRK11598 436717001897 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 436717001898 Sulfatase; Region: Sulfatase; pfam00884 436717001899 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 436717001900 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 436717001901 active site 436717001902 phosphorylation site [posttranslational modification] 436717001903 intermolecular recognition site; other site 436717001904 dimerization interface [polypeptide binding]; other site 436717001905 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 436717001906 DNA binding site [nucleotide binding] 436717001907 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 436717001908 dimer interface [polypeptide binding]; other site 436717001909 phosphorylation site [posttranslational modification] 436717001910 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 436717001911 ATP binding site [chemical binding]; other site 436717001912 Mg2+ binding site [ion binding]; other site 436717001913 G-X-G motif; other site 436717001914 PAP2_like_6 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which mainly contains bacterial proteins, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_6; cd03396 436717001915 active site 436717001916 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 436717001917 Transcriptional regulator [Transcription]; Region: LysR; COG0583 436717001918 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 436717001919 putative DNA binding site [nucleotide binding]; other site 436717001920 putative Zn2+ binding site [ion binding]; other site 436717001921 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 436717001922 dimerization interface [polypeptide binding]; other site 436717001923 Predicted permeases [General function prediction only]; Region: COG0679 436717001924 Protein of unknown function DUF262; Region: DUF262; pfam03235 436717001925 Uncharacterized conserved protein [Function unknown]; Region: COG1479 436717001926 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 436717001927 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 436717001928 HIGH motif; other site 436717001929 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 436717001930 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 436717001931 active site 436717001932 KMSKS motif; other site 436717001933 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 436717001934 tRNA binding surface [nucleotide binding]; other site 436717001935 anticodon binding site; other site 436717001936 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 436717001937 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 436717001938 short chain dehydrogenase; Provisional; Region: PRK06181 436717001939 NAD(P) binding site [chemical binding]; other site 436717001940 active site 436717001941 SnoaL-like domain; Region: SnoaL_4; pfam13577 436717001942 Uncharacterized conserved protein [Function unknown]; Region: COG0393 436717001943 Putative heavy-metal-binding; Region: YbjQ_1; cl00426 436717001944 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 436717001945 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 436717001946 Protein export membrane protein; Region: SecD_SecF; cl14618 436717001947 multidrug efflux system transporter AcrA; Provisional; Region: PRK15030 436717001948 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 436717001949 HlyD family secretion protein; Region: HlyD_3; pfam13437 436717001950 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 436717001951 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 436717001952 active site 436717001953 Site-specific recombinase; Region: SpecificRecomb; pfam10136 436717001954 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 436717001955 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 436717001956 substrate binding pocket [chemical binding]; other site 436717001957 chain length determination region; other site 436717001958 substrate-Mg2+ binding site; other site 436717001959 catalytic residues [active] 436717001960 aspartate-rich region 1; other site 436717001961 active site lid residues [active] 436717001962 aspartate-rich region 2; other site 436717001963 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 436717001964 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 436717001965 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 436717001966 lipoprotein chaperone; Reviewed; Region: lolA; PRK00031 436717001967 Outer membrane lipoprotein carrier protein LolA; Region: LolA; pfam03548 436717001968 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 436717001969 seryl-tRNA synthetase; Provisional; Region: PRK05431 436717001970 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 436717001971 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 436717001972 dimer interface [polypeptide binding]; other site 436717001973 active site 436717001974 motif 1; other site 436717001975 motif 2; other site 436717001976 motif 3; other site 436717001977 siroheme synthase; Provisional; Region: cysG; PRK10637 436717001978 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 436717001979 Sirohaem synthase dimerisation region; Region: CysG_dimeriser; pfam10414 436717001980 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 436717001981 active site 436717001982 SAM binding site [chemical binding]; other site 436717001983 homodimer interface [polypeptide binding]; other site 436717001984 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 436717001985 Cupin-like domain; Region: Cupin_8; pfam13621 436717001986 Predicted transcriptional regulators [Transcription]; Region: COG1733 436717001987 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 436717001988 dimerization interface [polypeptide binding]; other site 436717001989 putative DNA binding site [nucleotide binding]; other site 436717001990 putative Zn2+ binding site [ion binding]; other site 436717001991 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 436717001992 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 436717001993 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 436717001994 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 436717001995 Iron-containing alcohol dehydrogenases-like; Region: Fe-ADH5; cd08189 436717001996 putative active site [active] 436717001997 metal binding site [ion binding]; metal-binding site 436717001998 lipoate-protein ligase B; Provisional; Region: PRK14342 436717001999 Protein of unknown function (DUF493); Region: DUF493; pfam04359 436717002000 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 436717002001 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 436717002002 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 436717002003 Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546 436717002004 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 436717002005 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 436717002006 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 436717002007 DNA binding residues [nucleotide binding] 436717002008 Uncharacterized protein family (UPF0149); Region: UPF0149; pfam03695 436717002009 Predicted sulfurtransferase [General function prediction only]; Region: COG1054 436717002010 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 436717002011 active site residue [active] 436717002012 Protein of unknown function (DUF1289); Region: DUF1289; pfam06945 436717002013 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 436717002014 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 436717002015 dimer interface [polypeptide binding]; other site 436717002016 active site 436717002017 citrylCoA binding site [chemical binding]; other site 436717002018 NADH binding [chemical binding]; other site 436717002019 cationic pore residues; other site 436717002020 oxalacetate/citrate binding site [chemical binding]; other site 436717002021 coenzyme A binding site [chemical binding]; other site 436717002022 catalytic triad [active] 436717002023 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499 436717002024 proximal quinone binding site [chemical binding]; other site 436717002025 SdhD (CybS) interface [polypeptide binding]; other site 436717002026 proximal heme binding site [chemical binding]; other site 436717002027 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. E. coli SQR, a member of this subfamily, reduces the...; Region: SQR_TypeC_SdhD; cd03494 436717002028 SdhC subunit interface [polypeptide binding]; other site 436717002029 proximal heme binding site [chemical binding]; other site 436717002030 cardiolipin binding site; other site 436717002031 Iron-sulfur protein interface; other site 436717002032 proximal quinone binding site [chemical binding]; other site 436717002033 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07057 436717002034 L-aspartate oxidase; Provisional; Region: PRK06175 436717002035 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 436717002036 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 436717002037 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 436717002038 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 436717002039 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 436717002040 TPP-binding site [chemical binding]; other site 436717002041 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 436717002042 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 436717002043 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 436717002044 E3 interaction surface; other site 436717002045 lipoyl attachment site [posttranslational modification]; other site 436717002046 e3 binding domain; Region: E3_binding; pfam02817 436717002047 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 436717002048 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06467 436717002049 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 436717002050 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 436717002051 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 436717002052 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 436717002053 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 436717002054 CoA-ligase; Region: Ligase_CoA; pfam00549 436717002055 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 436717002056 CoA binding domain; Region: CoA_binding; smart00881 436717002057 CoA-ligase; Region: Ligase_CoA; pfam00549 436717002058 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 436717002059 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 436717002060 active site 436717002061 HIGH motif; other site 436717002062 dimer interface [polypeptide binding]; other site 436717002063 KMSKS motif; other site 436717002064 Protein of unknown function (DUF808); Region: DUF808; pfam05661 436717002065 Predicted metalloprotease [General function prediction only]; Region: COG2321 436717002066 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 436717002067 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 436717002068 potential frameshift: common BLAST hit: gi|213157636|ref|YP_002320434.1| biofilm-associated protein 436717002069 type 2 lantibiotic biosynthesis protein LanM; Region: lanti_2_LanM; TIGR03897 436717002070 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 436717002071 putative active site [active] 436717002072 putative metal binding site [ion binding]; other site 436717002073 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 436717002074 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 436717002075 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 436717002076 active site 436717002077 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 436717002078 DNA binding site [nucleotide binding] 436717002079 active site 436717002080 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 436717002081 Ligand Binding Site [chemical binding]; other site 436717002082 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 436717002083 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 436717002084 trimer interface [polypeptide binding]; other site 436717002085 active site 436717002086 substrate binding site [chemical binding]; other site 436717002087 CoA binding site [chemical binding]; other site 436717002088 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 436717002089 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 436717002090 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 436717002091 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 436717002092 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 436717002093 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 436717002094 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 436717002095 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 436717002096 ATP-grasp domain; Region: ATP-grasp_4; cl17255 436717002097 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 436717002098 IMP binding site; other site 436717002099 dimer interface [polypeptide binding]; other site 436717002100 interdomain contacts; other site 436717002101 partial ornithine binding site; other site 436717002102 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 436717002103 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 436717002104 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 436717002105 catalytic site [active] 436717002106 subunit interface [polypeptide binding]; other site 436717002107 Domon-like domain of UDP-N-acetylenolpyruvoylglucosamine reductase; Region: DOMON_murB_like; cd09627 436717002108 putative heme binding site [chemical binding]; other site 436717002109 CRS1 / YhbY (CRM) domain; Region: CRS1_YhbY; pfam01985 436717002110 FtsJ-like methyltransferase; Region: FtsJ; cl17430 436717002111 23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293 436717002112 FtsH Extracellular; Region: FtsH_ext; pfam06480 436717002113 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 436717002114 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 436717002115 Walker A motif; other site 436717002116 ATP binding site [chemical binding]; other site 436717002117 Walker B motif; other site 436717002118 arginine finger; other site 436717002119 Peptidase family M41; Region: Peptidase_M41; pfam01434 436717002120 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 436717002121 dihydropteroate synthase; Region: DHPS; TIGR01496 436717002122 substrate binding pocket [chemical binding]; other site 436717002123 dimer interface [polypeptide binding]; other site 436717002124 inhibitor binding site; inhibition site 436717002125 PhoD-like phosphatase; Region: PhoD; pfam09423 436717002126 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 436717002127 putative active site [active] 436717002128 putative metal binding site [ion binding]; other site 436717002129 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 436717002130 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14192 436717002131 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 436717002132 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 436717002133 homodimer interface [polypeptide binding]; other site 436717002134 NADP binding site [chemical binding]; other site 436717002135 substrate binding site [chemical binding]; other site 436717002136 Predicted methyltransferase [General function prediction only]; Region: COG3897 436717002137 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 436717002138 S-adenosylmethionine binding site [chemical binding]; other site 436717002139 alpha-ketoglutarate transporter; Provisional; Region: PRK10406 436717002140 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 436717002141 putative substrate translocation pore; other site 436717002142 glycerol kinase; Provisional; Region: glpK; PRK00047 436717002143 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 436717002144 N- and C-terminal domain interface [polypeptide binding]; other site 436717002145 active site 436717002146 MgATP binding site [chemical binding]; other site 436717002147 catalytic site [active] 436717002148 metal binding site [ion binding]; metal-binding site 436717002149 glycerol binding site [chemical binding]; other site 436717002150 homotetramer interface [polypeptide binding]; other site 436717002151 homodimer interface [polypeptide binding]; other site 436717002152 FBP binding site [chemical binding]; other site 436717002153 protein IIAGlc interface [polypeptide binding]; other site 436717002154 glycerol-3-phosphate dehydrogenase; Reviewed; Region: glpD; PRK12266 436717002155 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819 436717002156 active site 436717002157 substrate-binding site [chemical binding]; other site 436717002158 metal-binding site [ion binding] 436717002159 GTP binding site [chemical binding]; other site 436717002160 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 436717002161 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 436717002162 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 436717002163 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 436717002164 active site 436717002165 metal binding site [ion binding]; metal-binding site 436717002166 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 436717002167 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 436717002168 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 436717002169 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 436717002170 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 436717002171 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 436717002172 type I secretion C-terminal target domain (VC_A0849 subclass); Region: T1SS_VCA0849; TIGR03661 436717002173 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 436717002174 oligomerisation interface [polypeptide binding]; other site 436717002175 mobile loop; other site 436717002176 roof hairpin; other site 436717002177 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 436717002178 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 436717002179 ring oligomerisation interface [polypeptide binding]; other site 436717002180 ATP/Mg binding site [chemical binding]; other site 436717002181 stacking interactions; other site 436717002182 hinge regions; other site 436717002183 Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818 436717002184 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 436717002185 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 436717002186 Glycerophosphodiester phosphodiesterase domain of Streptomycin coelicolor (GlpQ1) and similar proteins; Region: GDPD_ScGlpQ1_like; cd08602 436717002187 putative active site [active] 436717002188 catalytic site [active] 436717002189 putative metal binding site [ion binding]; other site 436717002190 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 436717002191 Domain of unknown function (DUF4112); Region: DUF4112; pfam13430 436717002192 heat shock protein HtpX; Provisional; Region: PRK05457 436717002193 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 436717002194 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 436717002195 N-acetyl-D-glucosamine binding site [chemical binding]; other site 436717002196 catalytic residue [active] 436717002197 tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696 436717002198 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 436717002199 Ligand Binding Site [chemical binding]; other site 436717002200 SCP-2 sterol transfer family; Region: SCP2; pfam02036 436717002201 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 436717002202 N-acetyl-D-glucosamine binding site [chemical binding]; other site 436717002203 catalytic residue [active] 436717002204 transcription elongation factor GreB; Reviewed; Region: greB; PRK01885 436717002205 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 436717002206 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 436717002207 short chain dehydrogenase; Provisional; Region: PRK06523 436717002208 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 436717002209 NAD(P) binding site [chemical binding]; other site 436717002210 active site 436717002211 SnoaL-like domain; Region: SnoaL_2; pfam12680 436717002212 Transcriptional regulator [Transcription]; Region: LysR; COG0583 436717002213 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 436717002214 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 436717002215 putative effector binding pocket; other site 436717002216 putative dimerization interface [polypeptide binding]; other site 436717002217 The adenylation (A) domain of siderophore-synthesizing nonribosomal peptide synthetases (NRPS); Region: A_NRPS_SidN3_like; cd05918 436717002218 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 436717002219 acyl-activating enzyme (AAE) consensus motif; other site 436717002220 AMP binding site [chemical binding]; other site 436717002221 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 436717002222 non-ribosomal peptide synthetase terminal domain of unknown function; Region: NRPS_term_dom; TIGR02353 436717002223 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 436717002224 putative trimer interface [polypeptide binding]; other site 436717002225 putative CoA binding site [chemical binding]; other site 436717002226 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 436717002227 putative CoA binding site [chemical binding]; other site 436717002228 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 436717002229 putative trimer interface [polypeptide binding]; other site 436717002230 putative CoA binding site [chemical binding]; other site 436717002231 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 436717002232 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 436717002233 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 436717002234 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 436717002235 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687 436717002236 Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118 436717002237 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 436717002238 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 436717002239 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 436717002240 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 436717002241 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 436717002242 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 436717002243 FMN binding site [chemical binding]; other site 436717002244 active site 436717002245 substrate binding site [chemical binding]; other site 436717002246 catalytic residue [active] 436717002247 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 436717002248 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 436717002249 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 436717002250 Alpha/beta hydrolase of unknown function (DUF1057); Region: DUF1057; pfam06342 436717002251 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 436717002252 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 436717002253 AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246 436717002254 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 436717002255 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 436717002256 HlyD family secretion protein; Region: HlyD_3; pfam13437 436717002257 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 436717002258 Protein export membrane protein; Region: SecD_SecF; cl14618 436717002259 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 436717002260 dimer interface [polypeptide binding]; other site 436717002261 FMN binding site [chemical binding]; other site 436717002262 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 436717002263 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 436717002264 NAD(P) binding site [chemical binding]; other site 436717002265 active site 436717002266 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 436717002267 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 436717002268 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 436717002269 oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701 436717002270 The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767 436717002271 putative molybdopterin cofactor binding site [chemical binding]; other site 436717002272 The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787 436717002273 putative molybdopterin cofactor binding site; other site 436717002274 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 436717002275 erythronate-4-phosphate dehydrogenase; Validated; Region: PRK00257 436717002276 D-Erythronate-4-Phosphate Dehydrogenase NAD-binding and catalytic domains; Region: ErythrP_dh; cd12158 436717002277 ligand binding site [chemical binding]; other site 436717002278 NAD binding site [chemical binding]; other site 436717002279 catalytic site [active] 436717002280 homodimer interface [polypeptide binding]; other site 436717002281 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 436717002282 EF-P lysine aminoacylase GenX; Region: genX; TIGR00462 436717002283 motif 1; other site 436717002284 dimer interface [polypeptide binding]; other site 436717002285 active site 436717002286 motif 2; other site 436717002287 motif 3; other site 436717002288 Tim44 is an essential component of the machinery that mediates the translocation of nuclear-encoded proteins across the mitochondrial inner membrane; Region: Tim44; smart00978 436717002289 DNA repair protein RadA; Provisional; Region: PRK11823 436717002290 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 436717002291 Walker A motif/ATP binding site; other site 436717002292 ATP binding site [chemical binding]; other site 436717002293 Walker B motif; other site 436717002294 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 436717002295 D-alanine/D-serine/glycine permease; Provisional; Region: PRK11049 436717002296 diaminopimelate decarboxylase; Region: lysA; TIGR01048 436717002297 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 436717002298 active site 436717002299 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 436717002300 substrate binding site [chemical binding]; other site 436717002301 catalytic residues [active] 436717002302 dimer interface [polypeptide binding]; other site 436717002303 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 436717002304 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 436717002305 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 436717002306 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 436717002307 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 436717002308 catalytic site [active] 436717002309 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 436717002310 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 436717002311 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 436717002312 active site 436717002313 DNA binding site [nucleotide binding] 436717002314 Int/Topo IB signature motif; other site 436717002315 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 436717002316 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 436717002317 Ligand binding site [chemical binding]; other site 436717002318 Electron transfer flavoprotein domain; Region: ETF; pfam01012 436717002319 electron transfer flavoprotein subunit alpha; Provisional; Region: PLN00022 436717002320 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 436717002321 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 436717002322 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 436717002323 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 436717002324 DNA gyrase subunit A; Validated; Region: PRK05560 436717002325 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 436717002326 CAP-like domain; other site 436717002327 active site 436717002328 primary dimer interface [polypeptide binding]; other site 436717002329 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 436717002330 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 436717002331 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 436717002332 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 436717002333 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 436717002334 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 436717002335 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 436717002336 GtrA-like protein; Region: GtrA; pfam04138 436717002337 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 436717002338 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 436717002339 Ligand binding site; other site 436717002340 Putative Catalytic site; other site 436717002341 DXD motif; other site 436717002342 uncharacterized YdjC-like family proteins from bacteria; Region: YdjC_like_3; cd10807 436717002343 putative active site [active] 436717002344 YdjC motif; other site 436717002345 Mg binding site [ion binding]; other site 436717002346 putative homodimer interface [polypeptide binding]; other site 436717002347 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 436717002348 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 436717002349 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 436717002350 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 436717002351 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 436717002352 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 436717002353 HlyD family secretion protein; Region: HlyD_3; pfam13437 436717002354 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 436717002355 Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT). PSAT is active as...; Region: PSAT_like; cd00611 436717002356 homodimer interface [polypeptide binding]; other site 436717002357 substrate-cofactor binding pocket; other site 436717002358 pyridoxal 5'-phosphate binding site [chemical binding]; other site 436717002359 catalytic residue [active] 436717002360 Uncharacterized BCR, YaiI/YqxD family COG1671; Region: DUF188; pfam02639 436717002361 putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272 436717002362 EamA-like transporter family; Region: EamA; pfam00892 436717002363 EamA-like transporter family; Region: EamA; pfam00892 436717002364 lipoprotein releasing system, transmembrane protein, LolC/E family; Region: lolCE; TIGR02212 436717002365 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 436717002366 FtsX-like permease family; Region: FtsX; pfam02687 436717002367 lipoprotein releasing system, ATP-binding protein; Region: LolD_lipo_ex; TIGR02211 436717002368 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 436717002369 Walker A/P-loop; other site 436717002370 ATP binding site [chemical binding]; other site 436717002371 Q-loop/lid; other site 436717002372 ABC transporter signature motif; other site 436717002373 Walker B; other site 436717002374 D-loop; other site 436717002375 H-loop/switch region; other site 436717002376 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 436717002377 DNA internalization-related competence protein ComEC/Rec2; Region: ComEC_Rec2; TIGR00361 436717002378 Competence protein; Region: Competence; pfam03772 436717002379 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 436717002380 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 436717002381 putative acyl-acceptor binding pocket; other site 436717002382 Periplasmic serine proteases (ClpP class) [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: SppA; COG0616 436717002383 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 436717002384 tandem repeat interface [polypeptide binding]; other site 436717002385 oligomer interface [polypeptide binding]; other site 436717002386 active site residues [active] 436717002387 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 436717002388 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 436717002389 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 436717002390 active site 436717002391 substrate binding site [chemical binding]; other site 436717002392 cosubstrate binding site; other site 436717002393 catalytic site [active] 436717002394 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 436717002395 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 436717002396 dimerization interface [polypeptide binding]; other site 436717002397 putative ATP binding site [chemical binding]; other site 436717002398 Domain of unknown function DUF20; Region: UPF0118; pfam01594 436717002399 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 436717002400 ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593 436717002401 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 436717002402 Walker A motif; other site 436717002403 ATP binding site [chemical binding]; other site 436717002404 Walker B motif; other site 436717002405 arginine finger; other site 436717002406 Acinetobacter rhombotarget A; Region: GlyGly_RbtA; TIGR04212 436717002407 Acinetobacter rhombotarget A; Region: GlyGly_RbtA; TIGR04212 436717002408 CSLREA domain; Region: CSLREA_Nterm; TIGR04214 436717002409 Protein of unknown function (DUF3106); Region: DUF3106; pfam11304 436717002410 RNA polymerase factor sigma-70; Validated; Region: PRK09047 436717002411 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 436717002412 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 436717002413 DNA binding residues [nucleotide binding] 436717002414 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 436717002415 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 436717002416 fructose-1,6-bisphosphatase family protein; Region: PLN02628 436717002417 Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354 436717002418 AMP binding site [chemical binding]; other site 436717002419 metal binding site [ion binding]; metal-binding site 436717002420 active site 436717002421 peptidoglycan-associated outer membrane lipoprotein; Provisional; Region: PRK10802 436717002422 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 436717002423 ligand binding site [chemical binding]; other site 436717002424 translocation protein TolB; Provisional; Region: tolB; PRK04922 436717002425 TolB amino-terminal domain; Region: TolB_N; pfam04052 436717002426 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 436717002427 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 436717002428 TolA protein; Region: tolA_full; TIGR02794 436717002429 TonB C terminal; Region: TonB_2; pfam13103 436717002430 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 436717002431 TolR protein; Region: tolR; TIGR02801 436717002432 TolQ protein; Region: tolQ; TIGR02796 436717002433 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 436717002434 active site 436717002435 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like2; cd05667 436717002436 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 436717002437 metal binding site [ion binding]; metal-binding site 436717002438 putative dimer interface [polypeptide binding]; other site 436717002439 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 436717002440 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 436717002441 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 436717002442 Walker A motif; other site 436717002443 ATP binding site [chemical binding]; other site 436717002444 Walker B motif; other site 436717002445 arginine finger; other site 436717002446 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 436717002447 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 436717002448 RuvA N terminal domain; Region: RuvA_N; pfam01330 436717002449 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 436717002450 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01096 436717002451 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 436717002452 Zn2+ binding site [ion binding]; other site 436717002453 Mg2+ binding site [ion binding]; other site 436717002454 phosphoribosylformylglycinamidine synthase; Provisional; Region: PRK05297 436717002455 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 436717002456 dimerization interface [polypeptide binding]; other site 436717002457 ATP binding site [chemical binding]; other site 436717002458 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 436717002459 dimerization interface [polypeptide binding]; other site 436717002460 ATP binding site [chemical binding]; other site 436717002461 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 436717002462 putative active site [active] 436717002463 catalytic triad [active] 436717002464 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 436717002465 putative substrate translocation pore; other site 436717002466 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 436717002467 enoyl-CoA hydratase; Provisional; Region: PRK06688 436717002468 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 436717002469 substrate binding site [chemical binding]; other site 436717002470 oxyanion hole (OAH) forming residues; other site 436717002471 trimer interface [polypeptide binding]; other site 436717002472 nicotinamide-nucleotide adenylyltransferase; Provisional; Region: PRK13793 436717002473 Cytidylyltransferase; Region: CTP_transf_2; pfam01467 436717002474 active site 436717002475 nucleotide binding site [chemical binding]; other site 436717002476 HIGH motif; other site 436717002477 KMSKS motif; other site 436717002478 Putative lumazine-binding; Region: Lumazine_bd_2; pfam12893 436717002479 Bleomycin binding protein (BLMA) and similar proteins; BLMA confers bleomycin (Bm) resistance by directly binding to Bm; Region: BLMA_like; cd08349 436717002480 dimer interface [polypeptide binding]; other site 436717002481 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 436717002482 ligand binding site [chemical binding]; other site 436717002483 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 436717002484 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 436717002485 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 436717002486 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 436717002487 catalytic triad [active] 436717002488 Predicted ATPases of PP-loop superfamily [General function prediction only]; Region: COG2102 436717002489 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_IV; cd01994 436717002490 Ligand Binding Site [chemical binding]; other site 436717002491 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 436717002492 Ligand Binding Site [chemical binding]; other site 436717002493 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE, gammaproteobacterial type; Region: rSAM_QueE_gams; TIGR04349 436717002494 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 436717002495 FeS/SAM binding site; other site 436717002496 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830 436717002497 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 436717002498 active site 436717002499 substrate binding site [chemical binding]; other site 436717002500 trimer interface [polypeptide binding]; other site 436717002501 CoA binding site [chemical binding]; other site 436717002502 transcriptional regulator CysB-like protein; Reviewed; Region: PRK12683 436717002503 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 436717002504 The C-terminal substrate domain of LysR-type transcriptional regulators CysB-like contains type 2 periplasmic binding fold; Region: PBP2_CysB_like; cd08413 436717002505 substrate binding site [chemical binding]; other site 436717002506 dimerization interface [polypeptide binding]; other site 436717002507 ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118 436717002508 ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296 436717002509 Walker A/P-loop; other site 436717002510 ATP binding site [chemical binding]; other site 436717002511 Q-loop/lid; other site 436717002512 ABC transporter signature motif; other site 436717002513 Walker B; other site 436717002514 D-loop; other site 436717002515 H-loop/switch region; other site 436717002516 TOBE-like domain; Region: TOBE_3; pfam12857 436717002517 sulfate transport protein; Provisional; Region: cysT; CHL00187 436717002518 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 436717002519 dimer interface [polypeptide binding]; other site 436717002520 conserved gate region; other site 436717002521 putative PBP binding loops; other site 436717002522 ABC-ATPase subunit interface; other site 436717002523 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 436717002524 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 436717002525 dimer interface [polypeptide binding]; other site 436717002526 conserved gate region; other site 436717002527 putative PBP binding loops; other site 436717002528 ABC-ATPase subunit interface; other site 436717002529 Serine hydrolase; Region: Ser_hydrolase; pfam06821 436717002530 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 436717002531 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 436717002532 substrate binding pocket [chemical binding]; other site 436717002533 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 436717002534 membrane-bound complex binding site; other site 436717002535 hinge residues; other site 436717002536 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 436717002537 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 436717002538 pyridoxal 5'-phosphate binding site [chemical binding]; other site 436717002539 catalytic residue [active] 436717002540 YceG-like family; Region: YceG; pfam02618 436717002541 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 436717002542 dimerization interface [polypeptide binding]; other site 436717002543 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 436717002544 thymidylate kinase; Validated; Region: tmk; PRK00698 436717002545 TMP-binding site; other site 436717002546 ATP-binding site [chemical binding]; other site 436717002547 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 436717002548 CoenzymeA binding site [chemical binding]; other site 436717002549 subunit interaction site [polypeptide binding]; other site 436717002550 PHB binding site; other site 436717002551 L-aspartate oxidase; Provisional; Region: PRK09077 436717002552 L-aspartate oxidase; Provisional; Region: PRK06175 436717002553 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 436717002554 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 436717002555 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 436717002556 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 436717002557 protein binding site [polypeptide binding]; other site 436717002558 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 436717002559 protein binding site [polypeptide binding]; other site 436717002560 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 436717002561 active site 436717002562 GTP-binding protein LepA; Provisional; Region: PRK05433 436717002563 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 436717002564 G1 box; other site 436717002565 putative GEF interaction site [polypeptide binding]; other site 436717002566 GTP/Mg2+ binding site [chemical binding]; other site 436717002567 Switch I region; other site 436717002568 G2 box; other site 436717002569 G3 box; other site 436717002570 Switch II region; other site 436717002571 G4 box; other site 436717002572 G5 box; other site 436717002573 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 436717002574 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 436717002575 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 436717002576 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 436717002577 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 436717002578 Catalytic site [active] 436717002579 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 436717002580 ribonuclease III; Reviewed; Region: rnc; PRK00102 436717002581 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 436717002582 dimerization interface [polypeptide binding]; other site 436717002583 active site 436717002584 metal binding site [ion binding]; metal-binding site 436717002585 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 436717002586 dsRNA binding site [nucleotide binding]; other site 436717002587 GTPase Era; Reviewed; Region: era; PRK00089 436717002588 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 436717002589 G1 box; other site 436717002590 GTP/Mg2+ binding site [chemical binding]; other site 436717002591 Switch I region; other site 436717002592 G2 box; other site 436717002593 Switch II region; other site 436717002594 G3 box; other site 436717002595 G4 box; other site 436717002596 G5 box; other site 436717002597 KH domain; Region: KH_2; pfam07650 436717002598 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 436717002599 Recombination protein O N terminal; Region: RecO_N; pfam11967 436717002600 Recombination protein O C terminal; Region: RecO_C; pfam02565 436717002601 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003 436717002602 active site 436717002603 hydrophilic channel; other site 436717002604 dimerization interface [polypeptide binding]; other site 436717002605 catalytic residues [active] 436717002606 active site lid [active] 436717002607 MiaE tRNA-modifying nonheme diiron monooxygenase, ferritin-like diiron-binding domain; Region: MiaE; cd07910 436717002608 active site 436717002609 dinuclear metal binding site [ion binding]; other site 436717002610 dimerization interface [polypeptide binding]; other site 436717002611 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 436717002612 malonic semialdehyde reductase; Provisional; Region: PRK10538 436717002613 NAD(P) binding site [chemical binding]; other site 436717002614 active site 436717002615 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 436717002616 CoenzymeA binding site [chemical binding]; other site 436717002617 subunit interaction site [polypeptide binding]; other site 436717002618 PHB binding site; other site 436717002619 Uncharacterized conserved protein [Function unknown]; Region: COG3791 436717002620 aspartate aminotransferase; Provisional; Region: PRK05764 436717002621 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 436717002622 pyridoxal 5'-phosphate binding site [chemical binding]; other site 436717002623 homodimer interface [polypeptide binding]; other site 436717002624 catalytic residue [active] 436717002625 PAS domain; Region: PAS_9; pfam13426 436717002626 PAS domain; Region: PAS_9; pfam13426 436717002627 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 436717002628 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 436717002629 metal binding site [ion binding]; metal-binding site 436717002630 active site 436717002631 I-site; other site 436717002632 hypothetical protein; Region: PHA00684 436717002633 excinuclease ABC subunit B; Provisional; Region: PRK05298 436717002634 Myosin and Kinesin motor domain. These ATPases belong to the P-loop NTPase family and provide the driving force in myosin and kinesin mediated processes; Region: Motor_domain; cl00286 436717002635 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 436717002636 ATP-binding site [chemical binding]; other site 436717002637 ATP binding site [chemical binding]; other site 436717002638 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 436717002639 nucleotide binding region [chemical binding]; other site 436717002640 ATP-binding site [chemical binding]; other site 436717002641 Ultra-violet resistance protein B; Region: UvrB; pfam12344 436717002642 UvrB/uvrC motif; Region: UVR; pfam02151 436717002643 Lipocalin-like domain; Region: Lipocalin_2; pfam08212 436717002644 Predicted permeases [General function prediction only]; Region: RarD; COG2962 436717002645 glyceraldehyde-3-phosphate dehydrogenase; Reviewed; Region: PRK08289 436717002646 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 436717002647 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 436717002648 GTPase CgtA; Reviewed; Region: obgE; PRK12298 436717002649 GTP1/OBG; Region: GTP1_OBG; pfam01018 436717002650 Obg GTPase; Region: Obg; cd01898 436717002651 G1 box; other site 436717002652 GTP/Mg2+ binding site [chemical binding]; other site 436717002653 Switch I region; other site 436717002654 G2 box; other site 436717002655 G3 box; other site 436717002656 Switch II region; other site 436717002657 G4 box; other site 436717002658 G5 box; other site 436717002659 gamma-glutamyl kinase; Provisional; Region: PRK05429 436717002660 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 436717002661 nucleotide binding site [chemical binding]; other site 436717002662 homotetrameric interface [polypeptide binding]; other site 436717002663 putative phosphate binding site [ion binding]; other site 436717002664 putative allosteric binding site; other site 436717002665 PUA domain; Region: PUA; pfam01472 436717002666 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 436717002667 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 436717002668 Protein of unknown function (DUF1615); Region: DUF1615; pfam07759 436717002669 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 436717002670 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 436717002671 FMN binding site [chemical binding]; other site 436717002672 active site 436717002673 catalytic residues [active] 436717002674 substrate binding site [chemical binding]; other site 436717002675 Nitronate monooxygenase; Region: NMO; pfam03060 436717002676 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 436717002677 FMN binding site [chemical binding]; other site 436717002678 substrate binding site [chemical binding]; other site 436717002679 putative catalytic residue [active] 436717002680 Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_1; cd02432 436717002681 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 436717002682 TPR motif; other site 436717002683 binding surface 436717002684 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 436717002685 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 436717002686 DXD motif; other site 436717002687 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 436717002688 DNA photolyase; Region: DNA_photolyase; pfam00875 436717002689 FKBP-type peptidyl-prolyl cis-trans isomerases 2 [Posttranslational modification, protein turnover, chaperones]; Region: SlpA; COG1047 436717002690 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 436717002691 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 436717002692 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 436717002693 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 436717002694 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 436717002695 Predicted protease with the C-terminal PDZ domain [General function prediction only]; Region: COG3975 436717002696 M61 glycyl aminopeptidase; Region: Peptidase_M61; pfam05299 436717002697 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 436717002698 protein binding site [polypeptide binding]; other site 436717002699 Monomeric isocitrate dehydrogenase [Energy production and conversion]; Region: Icd; COG2838 436717002700 Monomeric isocitrate dehydrogenase; Region: IDH; cl15383 436717002701 Pseudouridine synthase, Escherichia coli RluE; Region: PseudoU_synth_RluE; cd02566 436717002702 pseudouridine synthase; Region: TIGR00093 436717002703 probable active site [active] 436717002704 isocitrate dehydrogenase; Validated; Region: PRK07362 436717002705 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 436717002706 Major Facilitator Superfamily; Region: MFS_1; pfam07690 436717002707 Protein of unknown function (DUF1228); Region: DUF1228; pfam06779 436717002708 Transcriptional regulator [Transcription]; Region: LysR; COG0583 436717002709 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 436717002710 The C-terminal substrate binding domain of LysR-type transcriptional regulators, YofA and SoxR, contains the type 2 periplasmic binding fold; Region: PBP2_YofA_SoxR_like; cd08442 436717002711 putative dimerization interface [polypeptide binding]; other site 436717002712 Predicted Na+/dicarboxylate symporter [General function prediction only]; Region: COG1823 436717002713 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 436717002714 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 436717002715 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 436717002716 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 436717002717 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 436717002718 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 436717002719 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 436717002720 Protein of unknown function (DUF3144); Region: DUF3144; pfam11342 436717002721 Uncharacterized conserved protein [Function unknown]; Region: COG3025 436717002722 Uncharacterized subgroup of the CYTH-like superfamily having an associated CHAD domain; Region: CYTH-like_Pase_CHAD; cd07756 436717002723 putative active site [active] 436717002724 putative metal binding residues [ion binding]; other site 436717002725 signature motif; other site 436717002726 putative triphosphate binding site [ion binding]; other site 436717002727 CHAD domain; Region: CHAD; pfam05235 436717002728 Protein of unknown function (DUF962); Region: DUF962; pfam06127 436717002729 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 436717002730 thiamine phosphate binding site [chemical binding]; other site 436717002731 active site 436717002732 pyrophosphate binding site [ion binding]; other site 436717002733 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 436717002734 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 436717002735 inhibitor-cofactor binding pocket; inhibition site 436717002736 pyridoxal 5'-phosphate binding site [chemical binding]; other site 436717002737 catalytic residue [active] 436717002738 Predicted transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: COG1548; cl00668 436717002739 Phosphopantetheine attachment site; Region: PP-binding; cl09936 436717002740 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 436717002741 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 436717002742 active site 436717002743 ATP-dependent helicase HepA; Validated; Region: PRK04914 436717002744 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 436717002745 ATP binding site [chemical binding]; other site 436717002746 putative Mg++ binding site [ion binding]; other site 436717002747 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 436717002748 nucleotide binding region [chemical binding]; other site 436717002749 ATP-binding site [chemical binding]; other site 436717002750 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465 436717002751 DNA-binding transcriptional repressor FabR; Provisional; Region: PRK11202 436717002752 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 436717002753 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_2; cd06216 436717002754 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 436717002755 FAD binding pocket [chemical binding]; other site 436717002756 FAD binding motif [chemical binding]; other site 436717002757 phosphate binding motif [ion binding]; other site 436717002758 beta-alpha-beta structure motif; other site 436717002759 NAD binding pocket [chemical binding]; other site 436717002760 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 436717002761 catalytic loop [active] 436717002762 iron binding site [ion binding]; other site 436717002763 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 436717002764 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 436717002765 putative di-iron ligands [ion binding]; other site 436717002766 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 436717002767 CoenzymeA binding site [chemical binding]; other site 436717002768 subunit interaction site [polypeptide binding]; other site 436717002769 PHB binding site; other site 436717002770 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 436717002771 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 436717002772 Protein of unknown function (DUF541); Region: SIMPL; cl01077 436717002773 diaminobutyrate--2-oxoglutarate aminotransferase; Provisional; Region: PRK06931 436717002774 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 436717002775 inhibitor-cofactor binding pocket; inhibition site 436717002776 pyridoxal 5'-phosphate binding site [chemical binding]; other site 436717002777 catalytic residue [active] 436717002778 DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450 436717002779 pyridoxal 5'-phosphate binding site [chemical binding]; other site 436717002780 catalytic residue [active] 436717002781 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 436717002782 Streptomyces aureofaciens putative aldehyde dehydrogenase AldA (AAD23400)-like; Region: ALDH_AldA-AAD23400; cd07106 436717002783 NAD(P) binding site [chemical binding]; other site 436717002784 catalytic residues [active] 436717002785 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 436717002786 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 436717002787 AsnC family; Region: AsnC_trans_reg; pfam01037 436717002788 Pyruvate decarboxylase and related thiamine pyrophosphate-requiring enzymes [Carbohydrate transport and metabolism / Coenzyme metabolism / General function prediction only]; Region: COG3961 436717002789 Pyrimidine (PYR) binding domain of pyruvate decarboxylase (PDC), indolepyruvate decarboxylase (IPDC) and related proteins; Region: TPP_PYR_PDC_IPDC_like; cd07038 436717002790 dimer interface [polypeptide binding]; other site 436717002791 PYR/PP interface [polypeptide binding]; other site 436717002792 TPP binding site [chemical binding]; other site 436717002793 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 436717002794 Thiamine pyrophosphate (TPP) family, PDC_IPDC subfamily, TPP-binding module; composed of proteins similar to pyruvate decarboxylase (PDC) and indolepyruvate decarboxylase (IPDC). PDC, a key enzyme in alcoholic fermentation, catalyzes the conversion of...; Region: TPP_PDC_IPDC; cd02005 436717002795 TPP-binding site [chemical binding]; other site 436717002796 dimer interface [polypeptide binding]; other site 436717002797 aromatic amino acid transporter; Provisional; Region: PRK10238 436717002798 ABC-type phosphate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PstS; COG0226 436717002799 Phosphate ATP-binding cassette transporter; Region: DUF3708; pfam12501 436717002800 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 436717002801 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 436717002802 dimer interface [polypeptide binding]; other site 436717002803 conserved gate region; other site 436717002804 putative PBP binding loops; other site 436717002805 ABC-ATPase subunit interface; other site 436717002806 Domain of unknown function (DUF3333); Region: DUF3333; pfam11812 436717002807 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 436717002808 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 436717002809 dimer interface [polypeptide binding]; other site 436717002810 conserved gate region; other site 436717002811 putative PBP binding loops; other site 436717002812 ABC-ATPase subunit interface; other site 436717002813 phosphate transporter ATP-binding protein; Provisional; Region: PRK14235 436717002814 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 436717002815 Walker A/P-loop; other site 436717002816 ATP binding site [chemical binding]; other site 436717002817 Q-loop/lid; other site 436717002818 ABC transporter signature motif; other site 436717002819 Walker B; other site 436717002820 D-loop; other site 436717002821 H-loop/switch region; other site 436717002822 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 436717002823 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 436717002824 tandem repeat interface [polypeptide binding]; other site 436717002825 oligomer interface [polypeptide binding]; other site 436717002826 active site residues [active] 436717002827 Predicted membrane protein (DUF2238); Region: DUF2238; pfam09997 436717002828 adenylosuccinate lyase; Provisional; Region: PRK09285 436717002829 PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598 436717002830 tetramer interface [polypeptide binding]; other site 436717002831 active site 436717002832 putative lysogenization regulator; Reviewed; Region: PRK00218 436717002833 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 436717002834 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 436717002835 Contains a crystal structure of the Nudix hydrolase from Nitrosomonas europaea, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_2; cd03675 436717002836 nudix motif; other site 436717002837 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 436717002838 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 436717002839 trimer interface [polypeptide binding]; other site 436717002840 putative metal binding site [ion binding]; other site 436717002841 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 436717002842 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 436717002843 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 436717002844 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 436717002845 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 436717002846 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 436717002847 Peptidase family M23; Region: Peptidase_M23; pfam01551 436717002848 transcriptional regulator; Provisional; Region: PRK10632 436717002849 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 436717002850 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 436717002851 putative effector binding pocket; other site 436717002852 dimerization interface [polypeptide binding]; other site 436717002853 AAA domain; Region: AAA_32; pfam13654 436717002854 lon-related putative ATP-dependent protease; Region: lon_rel; TIGR00764 436717002855 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 436717002856 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 436717002857 putative substrate translocation pore; other site 436717002858 muropeptide transporter; Validated; Region: ampG; cl17669 436717002859 muropeptide transporter; Validated; Region: ampG; cl17669 436717002860 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 436717002861 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 436717002862 dimer interface [polypeptide binding]; other site 436717002863 active site 436717002864 metal binding site [ion binding]; metal-binding site 436717002865 glutathione binding site [chemical binding]; other site 436717002866 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 436717002867 SBF-like CPA transporter family (DUF4137); Region: DUF4137; pfam13593 436717002868 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 436717002869 PAS domain S-box; Region: sensory_box; TIGR00229 436717002870 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 436717002871 Lysine 2,3-aminomutase [Amino acid transport and metabolism]; Region: KamA; COG1509 436717002872 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 436717002873 FeS/SAM binding site; other site 436717002874 elongation factor P; Validated; Region: PRK00529 436717002875 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 436717002876 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 436717002877 RNA binding site [nucleotide binding]; other site 436717002878 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 436717002879 RNA binding site [nucleotide binding]; other site 436717002880 carbon starvation protein A; Provisional; Region: PRK15015 436717002881 Carbon starvation protein CstA; Region: CstA; pfam02554 436717002882 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 436717002883 Protein of unknown function (DUF466); Region: DUF466; pfam04328 436717002884 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 436717002885 AAA domain; Region: AAA_21; pfam13304 436717002886 Walker A/P-loop; other site 436717002887 ATP binding site [chemical binding]; other site 436717002888 Predicted ATP-binding protein involved in virulence [General function prediction only]; Region: COG3950 436717002889 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 436717002890 active site 436717002891 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 436717002892 DNA-binding site [nucleotide binding]; DNA binding site 436717002893 RNA-binding motif; other site 436717002894 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 436717002895 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 436717002896 Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059 436717002897 chromate transporter, chromate ion transporter (CHR) family; Region: 2A51; TIGR00937 436717002898 Chromate transporter; Region: Chromate_transp; pfam02417 436717002899 Chromate resistance exported protein; Region: Chrome_Resist; pfam09828 436717002900 Transcriptional regulator [Transcription]; Region: LysR; COG0583 436717002901 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 436717002902 dimerization interface [polypeptide binding]; other site 436717002903 Predicted membrane protein [Function unknown]; Region: COG2259 436717002904 Domain of unknown function (DUF4104); Region: DUF4104; pfam13372 436717002905 Cytosol aminopeptidase family, N-terminal domain; Region: Peptidase_M17_N; pfam02789 436717002906 Predicted ornithine cyclodeaminase, mu-crystallin homolog [Amino acid transport and metabolism]; Region: COG2423 436717002907 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 436717002908 NAD(P) binding site [chemical binding]; other site 436717002909 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 436717002910 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 436717002911 tetramer interface [polypeptide binding]; other site 436717002912 pyridoxal 5'-phosphate binding site [chemical binding]; other site 436717002913 catalytic residue [active] 436717002914 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964 436717002915 YheO-like PAS domain; Region: PAS_6; pfam08348 436717002916 HTH domain; Region: HTH_22; pfam13309 436717002917 Pirin-related protein [General function prediction only]; Region: COG1741 436717002918 Pirin; Region: Pirin; pfam02678 436717002919 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 436717002920 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 436717002921 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 436717002922 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 436717002923 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 436717002924 substrate binding site [chemical binding]; other site 436717002925 active site 436717002926 Protein of unknown function (DUF817); Region: DUF817; cl01520 436717002927 Protein of unknown function (DUF3015); Region: DUF3015; pfam11220 436717002928 Domain of unknown function (DUF4105); Region: DUF4105; pfam13387 436717002929 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 436717002930 beta-lactamase/D-alanine carboxypeptidase; Provisional; Region: ampC; PRK11289 436717002931 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 436717002932 homodecamer interface [polypeptide binding]; other site 436717002933 GTP cyclohydrolase I; Provisional; Region: PLN03044 436717002934 active site 436717002935 putative catalytic site residues [active] 436717002936 zinc binding site [ion binding]; other site 436717002937 GTP-CH-I/GFRP interaction surface; other site 436717002938 xanthine dehydrogenase, small subunit; Region: xanthine_xdhA; TIGR02963 436717002939 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 436717002940 catalytic loop [active] 436717002941 iron binding site [ion binding]; other site 436717002942 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 436717002943 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450 436717002944 xanthine dehydrogenase, molybdopterin binding subunit; Region: xanthine_xdhB; TIGR02965 436717002945 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 436717002946 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 436717002947 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 436717002948 xanthine dehydrogenase accessory protein XdhC; Region: xanthine_xdhC; TIGR02964 436717002949 XdhC Rossmann domain; Region: XdhC_C; pfam13478 436717002950 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2840 436717002951 Smr domain; Region: Smr; pfam01713 436717002952 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 436717002953 active site 436717002954 ribulose/triose binding site [chemical binding]; other site 436717002955 phosphate binding site [ion binding]; other site 436717002956 substrate (anthranilate) binding pocket [chemical binding]; other site 436717002957 product (indole) binding pocket [chemical binding]; other site 436717002958 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 436717002959 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 436717002960 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 436717002961 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 436717002962 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 436717002963 glutamine binding [chemical binding]; other site 436717002964 catalytic triad [active] 436717002965 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 436717002966 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 436717002967 X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP; cd01085 436717002968 active site 436717002969 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 436717002970 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 436717002971 putative substrate translocation pore; other site 436717002972 POT family; Region: PTR2; cl17359 436717002973 glutamine synthetase; Provisional; Region: glnA; PRK09469 436717002974 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 436717002975 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 436717002976 Chorismate lyase; Region: Chor_lyase; cl01230 436717002977 4-hydroxybenzoate octaprenyltransferase; Reviewed; Region: ubiA; PRK12848 436717002978 UbiA prenyltransferase family; Region: UbiA; pfam01040 436717002979 Secretory lipase; Region: LIP; pfam03583 436717002980 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 436717002981 Protein of unknown function (DUF2726); Region: DUF2726; pfam10881 436717002982 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 436717002983 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 436717002984 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 436717002985 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371 436717002986 Uncharacterized conserved protein [Function unknown]; Region: COG0327 436717002987 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 436717002988 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 436717002989 protein binding site [polypeptide binding]; other site 436717002990 multifunctional tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase; Reviewed; Region: cca; PRK10885 436717002991 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 436717002992 active site 436717002993 NTP binding site [chemical binding]; other site 436717002994 metal binding triad [ion binding]; metal-binding site 436717002995 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 436717002996 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 436717002997 Zn2+ binding site [ion binding]; other site 436717002998 Mg2+ binding site [ion binding]; other site 436717002999 bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed; Region: PRK07232 436717003000 Malic enzyme, N-terminal domain; Region: malic; pfam00390 436717003001 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 436717003002 putative NAD(P) binding site [chemical binding]; other site 436717003003 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 436717003004 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 436717003005 heme pocket [chemical binding]; other site 436717003006 putative active site [active] 436717003007 RNase II stability modulator; Provisional; Region: PRK10060 436717003008 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 436717003009 putative active site [active] 436717003010 heme pocket [chemical binding]; other site 436717003011 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 436717003012 metal binding site [ion binding]; metal-binding site 436717003013 active site 436717003014 I-site; other site 436717003015 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 436717003016 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 436717003017 RNA methyltransferase, RsmE family; Region: TIGR00046 436717003018 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 436717003019 FAD binding site [chemical binding]; other site 436717003020 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 436717003021 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 436717003022 homotetramer interface [polypeptide binding]; other site 436717003023 ligand binding site [chemical binding]; other site 436717003024 catalytic site [active] 436717003025 NAD binding site [chemical binding]; other site 436717003026 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 436717003027 putative active site [active] 436717003028 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 436717003029 acyl-CoA dehydrogenase; Reviewed; Region: fadE; PRK09463 436717003030 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 436717003031 active site 436717003032 Domain of unknown function (DUF1974); Region: DUF1974; pfam09317 436717003033 lipoyl synthase; Provisional; Region: PRK05481 436717003034 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 436717003035 FeS/SAM binding site; other site 436717003036 soluble pyridine nucleotide transhydrogenase; Provisional; Region: PRK05249 436717003037 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 436717003038 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 436717003039 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 436717003040 Major Facilitator Superfamily; Region: MFS_1; pfam07690 436717003041 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 436717003042 nitrite extrusion protein (nitrite facilitator); Region: 2A0108; TIGR00886 436717003043 Outer membrane protein W [Cell envelope biogenesis, outer membrane]; Region: OmpW; COG3047 436717003044 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 436717003045 active site 436717003046 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 436717003047 rRNA interaction site [nucleotide binding]; other site 436717003048 S8 interaction site; other site 436717003049 putative laminin-1 binding site; other site 436717003050 elongation factor Ts; Provisional; Region: tsf; PRK09377 436717003051 UBA/TS-N domain; Region: UBA; pfam00627 436717003052 Elongation factor TS; Region: EF_TS; pfam00889 436717003053 Elongation factor TS; Region: EF_TS; pfam00889 436717003054 Protein of unknown function (DUF3465); Region: DUF3465; pfam11948 436717003055 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 436717003056 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 436717003057 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 436717003058 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 436717003059 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 436717003060 Branched-chain amino acid transport protein (AzlD); Region: AzlD; pfam05437 436717003061 Protein of unknown function (DUF962); Region: DUF962; pfam06127 436717003062 Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797 436717003063 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 436717003064 Transglycosylase SLT domain; Region: SLT_2; pfam13406 436717003065 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 436717003066 N-acetyl-D-glucosamine binding site [chemical binding]; other site 436717003067 catalytic residue [active] 436717003068 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 436717003069 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2904 436717003070 7-cyano-7-deazaguanine reductase; Provisional; Region: queF; PRK11792 436717003071 Enzyme related to GTP cyclohydrolase I [General function prediction only]; Region: COG0780 436717003072 inner membrane transport permease; Provisional; Region: PRK15066 436717003073 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 436717003074 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 436717003075 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 436717003076 Walker A/P-loop; other site 436717003077 ATP binding site [chemical binding]; other site 436717003078 Q-loop/lid; other site 436717003079 ABC transporter signature motif; other site 436717003080 Walker B; other site 436717003081 D-loop; other site 436717003082 H-loop/switch region; other site 436717003083 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 436717003084 exodeoxyribonuclease X; Provisional; Region: PRK07983 436717003085 active site 436717003086 catalytic site [active] 436717003087 substrate binding site [chemical binding]; other site 436717003088 Protein of unknown function (DUF3820); Region: DUF3820; cl01411 436717003089 Secretory lipase; Region: LIP; pfam03583 436717003090 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 436717003091 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 436717003092 dimer interface [polypeptide binding]; other site 436717003093 active site 436717003094 glycine-pyridoxal phosphate binding site [chemical binding]; other site 436717003095 folate binding site [chemical binding]; other site 436717003096 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 436717003097 AcrB/AcrD/AcrF family; Region: ACR_tran; pfam00873 436717003098 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 436717003099 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 436717003100 HlyD family secretion protein; Region: HlyD_3; pfam13437 436717003101 Transcriptional regulator [Transcription]; Region: LysR; COG0583 436717003102 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 436717003103 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 436717003104 putative effector binding pocket; other site 436717003105 putative dimerization interface [polypeptide binding]; other site 436717003106 lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096 436717003107 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 436717003108 substrate binding pocket [chemical binding]; other site 436717003109 membrane-bound complex binding site; other site 436717003110 hinge residues; other site 436717003111 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 436717003112 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 436717003113 dimer interface [polypeptide binding]; other site 436717003114 conserved gate region; other site 436717003115 putative PBP binding loops; other site 436717003116 ABC-ATPase subunit interface; other site 436717003117 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 436717003118 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 436717003119 dimer interface [polypeptide binding]; other site 436717003120 conserved gate region; other site 436717003121 putative PBP binding loops; other site 436717003122 ABC-ATPase subunit interface; other site 436717003123 ABC-type histidine transport system, ATPase component [Amino acid transport and metabolism]; Region: HisP; COG4598 436717003124 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 436717003125 Walker A/P-loop; other site 436717003126 ATP binding site [chemical binding]; other site 436717003127 Q-loop/lid; other site 436717003128 ABC transporter signature motif; other site 436717003129 Walker B; other site 436717003130 D-loop; other site 436717003131 H-loop/switch region; other site 436717003132 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 436717003133 archaeoflavoprotein, MJ0208 family; Region: flavo_MJ0208; TIGR02700 436717003134 putative protease; Provisional; Region: PRK15452 436717003135 Peptidase family U32; Region: Peptidase_U32; pfam01136 436717003136 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 436717003137 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 436717003138 DNA-binding site [nucleotide binding]; DNA binding site 436717003139 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 436717003140 pyridoxal 5'-phosphate binding site [chemical binding]; other site 436717003141 homodimer interface [polypeptide binding]; other site 436717003142 catalytic residue [active] 436717003143 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 436717003144 hydroxyproline-2-epimerase; Provisional; Region: PRK13971 436717003145 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 436717003146 Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195 436717003147 FAD binding pocket [chemical binding]; other site 436717003148 FAD binding motif [chemical binding]; other site 436717003149 phosphate binding motif [ion binding]; other site 436717003150 beta-alpha-beta structure motif; other site 436717003151 NAD binding pocket [chemical binding]; other site 436717003152 Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281 436717003153 homodimer interaction site [polypeptide binding]; other site 436717003154 cofactor binding site; other site 436717003155 Predicted membrane protein [Function unknown]; Region: COG3174 436717003156 Domain of unknown function (DUF4010); Region: DUF4010; pfam13194 436717003157 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 436717003158 Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804 436717003159 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 436717003160 Walker A motif; other site 436717003161 ATP binding site [chemical binding]; other site 436717003162 Walker B motif; other site 436717003163 Bacterial OB fold (BOF) protein; Region: BOF; cl01196 436717003164 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 436717003165 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 436717003166 active site 436717003167 phosphorylation site [posttranslational modification] 436717003168 intermolecular recognition site; other site 436717003169 dimerization interface [polypeptide binding]; other site 436717003170 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 436717003171 DNA binding site [nucleotide binding] 436717003172 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 436717003173 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 436717003174 dimer interface [polypeptide binding]; other site 436717003175 phosphorylation site [posttranslational modification] 436717003176 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 436717003177 ATP binding site [chemical binding]; other site 436717003178 Mg2+ binding site [ion binding]; other site 436717003179 G-X-G motif; other site 436717003180 Hemin uptake protein hemP; Region: hemP; cl10043 436717003181 hypothetical protein; Provisional; Region: PRK08999 436717003182 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 436717003183 active site 436717003184 8-oxo-dGMP binding site [chemical binding]; other site 436717003185 nudix motif; other site 436717003186 metal binding site [ion binding]; metal-binding site 436717003187 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 436717003188 thiamine phosphate binding site [chemical binding]; other site 436717003189 active site 436717003190 penicillin-binding protein 1B; Region: PBP_1b; TIGR02071 436717003191 Transglycosylase; Region: Transgly; pfam00912 436717003192 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 436717003193 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK01231 436717003194 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02231 436717003195 Protein of unknown function (DUF1315); Region: DUF1315; pfam07023 436717003196 hypothetical protein; Validated; Region: PRK09071 436717003197 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 436717003198 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 436717003199 C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663 436717003200 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 436717003201 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 436717003202 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 436717003203 active site 436717003204 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 436717003205 Chorismate mutase type II; Region: CM_2; cl00693 436717003206 Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077 436717003207 Prephenate dehydratase; Region: PDT; pfam00800 436717003208 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 436717003209 putative L-Phe binding site [chemical binding]; other site 436717003210 bifunctional cyclohexadienyl dehydrogenase/ 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK14806 436717003211 prephenate dehydrogenase; Validated; Region: PRK08507 436717003212 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 436717003213 hinge; other site 436717003214 active site 436717003215 Xaa-His dipeptidase; Region: aa-his-dipept; TIGR01893 436717003216 M20 Peptidase D has specificity for beta-alanyl-L-histidine dipeptide; Region: M20_pepD; cd03890 436717003217 metal binding site [ion binding]; metal-binding site 436717003218 dimer interface [polypeptide binding]; other site 436717003219 RNA 3'-terminal-phosphate cyclase; Provisional; Region: PRK04204 436717003220 This domain family includes the Enolpyruvate transferase (EPT) family and the RNA 3' phosphate cyclase family (RTPC). These 2 families differ in that EPT is formed by 3 repeats of an alpha-beta structural domain while RTPC has 3 similar repeats...; Region: EPT_RTPC-like; cl00288 436717003221 putative active site [active] 436717003222 potential frameshift: common BLAST hit: gi|260414702|ref|YP_003208314.1| septicolysin 436717003223 Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139 436717003224 hypothetical protein; Reviewed; Region: PRK09588 436717003225 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 436717003226 Sigma54-dependent transcription regulator containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: RtcR; COG4650 436717003227 Regulator of RNA terminal phosphate cyclase; Region: RtcR; pfam06956 436717003228 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 436717003229 Walker A motif; other site 436717003230 ATP binding site [chemical binding]; other site 436717003231 Walker B motif; other site 436717003232 arginine finger; other site 436717003233 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2945 436717003234 hypothetical protein; Validated; Region: PRK02101 436717003235 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4339 436717003236 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 436717003237 ThiS interaction site; other site 436717003238 putative active site [active] 436717003239 tetramer interface [polypeptide binding]; other site 436717003240 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 436717003241 thiS-thiF/thiG interaction site; other site 436717003242 Uncharacterized small membrane protein [Function unknown]; Region: COG2363 436717003243 RNA polymerase factor sigma-32; Reviewed; Region: PRK06596 436717003244 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 436717003245 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 436717003246 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 436717003247 DNA binding residues [nucleotide binding] 436717003248 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 436717003249 CPxP motif; other site 436717003250 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 436717003251 DNA-binding site [nucleotide binding]; DNA binding site 436717003252 RNA-binding motif; other site 436717003253 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 436717003254 DEAD-like helicases superfamily; Region: DEXDc; smart00487 436717003255 ATP binding site [chemical binding]; other site 436717003256 Mg++ binding site [ion binding]; other site 436717003257 motif III; other site 436717003258 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 436717003259 nucleotide binding region [chemical binding]; other site 436717003260 ATP-binding site [chemical binding]; other site 436717003261 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 436717003262 putative FMN binding site [chemical binding]; other site 436717003263 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 436717003264 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 436717003265 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 436717003266 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 436717003267 catalytic core [active] 436717003268 Type II secretion system (T2SS), protein L; Region: T2SL; pfam05134 436717003269 GspL periplasmic domain; Region: GspL_C; cl14909 436717003270 Type II secretion system (T2SS), protein M; Region: T2SM; cl01222 436717003271 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 436717003272 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 436717003273 quinone interaction residues [chemical binding]; other site 436717003274 active site 436717003275 catalytic residues [active] 436717003276 FMN binding site [chemical binding]; other site 436717003277 substrate binding site [chemical binding]; other site 436717003278 Colicin V production protein; Region: Colicin_V; pfam02674 436717003279 amidophosphoribosyltransferase; Provisional; Region: PRK09246 436717003280 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 436717003281 active site 436717003282 tetramer interface [polypeptide binding]; other site 436717003283 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 436717003284 active site 436717003285 Peptidase family M48; Region: Peptidase_M48; cl12018 436717003286 bifunctional glyoxylate/hydroxypyruvate reductase B; Provisional; Region: PRK15409 436717003287 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 436717003288 dimerization interface [polypeptide binding]; other site 436717003289 ligand binding site [chemical binding]; other site 436717003290 NADP binding site [chemical binding]; other site 436717003291 catalytic site [active] 436717003292 Putative Zn-dependent protease, contains TPR repeats [General function prediction only]; Region: COG4783 436717003293 Peptidase family M48; Region: Peptidase_M48; cl12018 436717003294 Yqey-like protein; Region: YqeY; pfam09424 436717003295 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 436717003296 UGMP family protein; Validated; Region: PRK09604 436717003297 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 436717003298 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG2607 436717003299 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 436717003300 Walker A motif; other site 436717003301 ATP binding site [chemical binding]; other site 436717003302 Walker B motif; other site 436717003303 Domain of unknown function (DUF3336); Region: DUF3336; pfam11815 436717003304 Triacylglycerol lipase 3, 4, and 5 and Sugar-Dependent 1 lipase; Region: Pat_TGL3-4-5_SDP1; cd07206 436717003305 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 436717003306 active site 436717003307 nucleophile elbow; other site 436717003308 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 436717003309 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 436717003310 substrate binding site [chemical binding]; other site 436717003311 activation loop (A-loop); other site 436717003312 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 436717003313 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 436717003314 DNA-binding site [nucleotide binding]; DNA binding site 436717003315 RNA-binding motif; other site 436717003316 Sensors of blue-light using FAD; Region: BLUF; pfam04940 436717003317 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 436717003318 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 436717003319 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 436717003320 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 436717003321 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 436717003322 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_3; cd13148 436717003323 putative efflux protein, MATE family; Region: matE; TIGR00797 436717003324 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 436717003325 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 436717003326 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 436717003327 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 436717003328 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 436717003329 HlyD family secretion protein; Region: HlyD_3; pfam13437 436717003330 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 436717003331 short chain dehydrogenase; Provisional; Region: PRK06179 436717003332 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 436717003333 NADP binding site [chemical binding]; other site 436717003334 active site 436717003335 steroid binding site; other site 436717003336 Predicted transcriptional regulators [Transcription]; Region: COG1733 436717003337 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 436717003338 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 436717003339 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 436717003340 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 436717003341 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 436717003342 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 436717003343 WHG domain; Region: WHG; pfam13305 436717003344 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 436717003345 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 436717003346 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 436717003347 Fatty acid desaturase; Region: FA_desaturase; pfam00487 436717003348 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 436717003349 putative di-iron ligands [ion binding]; other site 436717003350 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 436717003351 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 436717003352 FAD binding pocket [chemical binding]; other site 436717003353 conserved FAD binding motif [chemical binding]; other site 436717003354 phosphate binding motif [ion binding]; other site 436717003355 beta-alpha-beta structure motif; other site 436717003356 NAD binding pocket [chemical binding]; other site 436717003357 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 436717003358 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 436717003359 catalytic loop [active] 436717003360 iron binding site [ion binding]; other site 436717003361 Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167 436717003362 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 436717003363 Na+/glutamate symporter [Amino acid transport and metabolism]; Region: GltS; COG0786 436717003364 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 436717003365 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 436717003366 Kef-type K+ transport systems, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: Kch; COG1226 436717003367 TrkA-N domain; Region: TrkA_N; pfam02254 436717003368 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 436717003369 classical (c) SDRs; Region: SDR_c; cd05233 436717003370 NAD(P) binding site [chemical binding]; other site 436717003371 active site 436717003372 DoxX-like family; Region: DoxX_3; pfam13781 436717003373 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 436717003374 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 436717003375 aspartate 4-decarboxylase; Region: asp_4_decarbox; TIGR03801 436717003376 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 436717003377 pyridoxal 5'-phosphate binding site [chemical binding]; other site 436717003378 homodimer interface [polypeptide binding]; other site 436717003379 catalytic residue [active] 436717003380 aspartate-alanine antiporter; Region: Asp_Ala_antiprt; TIGR03802 436717003381 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 436717003382 TrkA-C domain; Region: TrkA_C; pfam02080 436717003383 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 436717003384 Paraquat-inducible protein A; Region: PqiA; pfam04403 436717003385 Uncharacterized paraquat-inducible protein A [Function unknown]; Region: PqiA; COG2995 436717003386 Paraquat-inducible protein A; Region: PqiA; pfam04403 436717003387 Paraquat-inducible protein B [General function prediction only]; Region: PqiB; COG3008 436717003388 mce related protein; Region: MCE; pfam02470 436717003389 mce related protein; Region: MCE; pfam02470 436717003390 mce related protein; Region: MCE; pfam02470 436717003391 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3009 436717003392 Protein of unknown function (DUF330); Region: DUF330; pfam03886 436717003393 HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822 436717003394 active site 436717003395 homotetramer interface [polypeptide binding]; other site 436717003396 Domain of unknown function (DUF336); Region: DUF336; cl01249 436717003397 heavy metal response regulator; Region: cztR_silR_copR; TIGR01387 436717003398 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 436717003399 active site 436717003400 phosphorylation site [posttranslational modification] 436717003401 intermolecular recognition site; other site 436717003402 dimerization interface [polypeptide binding]; other site 436717003403 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 436717003404 DNA binding site [nucleotide binding] 436717003405 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 436717003406 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 436717003407 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 436717003408 dimer interface [polypeptide binding]; other site 436717003409 phosphorylation site [posttranslational modification] 436717003410 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 436717003411 ATP binding site [chemical binding]; other site 436717003412 Mg2+ binding site [ion binding]; other site 436717003413 G-X-G motif; other site 436717003414 Bacterial lipocalin [Cell envelope biogenesis, outer membrane]; Region: Blc; COG3040 436717003415 Lipocalin-like domain; Region: Lipocalin_2; pfam08212 436717003416 Fatty acid desaturase; Region: FA_desaturase; pfam00487 436717003417 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 436717003418 Di-iron ligands [ion binding]; other site 436717003419 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 436717003420 Predicted NAD/FAD-binding protein [General function prediction only]; Region: COG2907 436717003421 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 436717003422 Protein of unknown function (DUF1365); Region: DUF1365; pfam07103 436717003423 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 436717003424 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 436717003425 S-adenosylmethionine binding site [chemical binding]; other site 436717003426 Protein of unknown function (DUF1295); Region: DUF1295; cl17837 436717003427 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 436717003428 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 436717003429 S-adenosylmethionine binding site [chemical binding]; other site 436717003430 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 436717003431 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 436717003432 dimer interface [polypeptide binding]; other site 436717003433 phosphorylation site [posttranslational modification] 436717003434 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 436717003435 ATP binding site [chemical binding]; other site 436717003436 Mg2+ binding site [ion binding]; other site 436717003437 G-X-G motif; other site 436717003438 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 436717003439 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 436717003440 active site 436717003441 phosphorylation site [posttranslational modification] 436717003442 intermolecular recognition site; other site 436717003443 dimerization interface [polypeptide binding]; other site 436717003444 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 436717003445 DNA binding site [nucleotide binding] 436717003446 SnoaL-like domain; Region: SnoaL_2; pfam12680 436717003447 aspartate racemase; Region: asp_race; TIGR00035 436717003448 Aspartate racemase [Cell envelope biogenesis, outer membrane]; Region: RacX; COG1794 436717003449 quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754 436717003450 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 436717003451 NADP binding site [chemical binding]; other site 436717003452 dimer interface [polypeptide binding]; other site 436717003453 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 436717003454 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 436717003455 Prokaryotic protein of unknown function (DUF849); Region: DUF849; pfam05853 436717003456 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 436717003457 Major Facilitator Superfamily; Region: MFS_1; pfam07690 436717003458 putative substrate translocation pore; other site 436717003459 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 436717003460 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 436717003461 catalytic residues [active] 436717003462 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 436717003463 iron-sulfur cluster [ion binding]; other site 436717003464 [2Fe-2S] cluster binding site [ion binding]; other site 436717003465 Predicted membrane protein [Function unknown]; Region: COG2855 436717003466 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 436717003467 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 436717003468 Serine hydrolase; Region: Ser_hydrolase; pfam06821 436717003469 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 436717003470 Protein of unknown function (DUF1302); Region: DUF1302; pfam06980 436717003471 Domain of unknown function (DUF1200); Region: DUF1200; pfam06713 436717003472 Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133 436717003473 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 436717003474 benzoate transport; Region: 2A0115; TIGR00895 436717003475 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 436717003476 putative substrate translocation pore; other site 436717003477 Transcriptional regulator [Transcription]; Region: LysR; COG0583 436717003478 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 436717003479 The C-terminal substrate binding domain of LysR-type transcriptional regulators that are involved in the catabolism of dinitrotoluene, naphthalene and gamma-hexachlorohexane; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_NahR_LinR_like; cd08459 436717003480 substrate binding pocket [chemical binding]; other site 436717003481 dimerization interface [polypeptide binding]; other site 436717003482 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 436717003483 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 436717003484 GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046 436717003485 putative C-terminal domain interface [polypeptide binding]; other site 436717003486 putative GSH binding site (G-site) [chemical binding]; other site 436717003487 maleylacetoacetate isomerase; Region: maiA; TIGR01262 436717003488 putative dimer interface [polypeptide binding]; other site 436717003489 C-terminal, alpha helical domain of an unknown subfamily 8 of Glutathione S-transferases; Region: GST_C_8; cd03207 436717003490 dimer interface [polypeptide binding]; other site 436717003491 N-terminal domain interface [polypeptide binding]; other site 436717003492 putative substrate binding pocket (H-site) [chemical binding]; other site 436717003493 Major Facilitator Superfamily; Region: MFS_1; pfam07690 436717003494 putative substrate translocation pore; other site 436717003495 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl17904 436717003496 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 436717003497 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 436717003498 C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663 436717003499 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 436717003500 hydroxyacylglutathione hydrolase; Region: GSH_gloB; TIGR03413 436717003501 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 436717003502 dimer interface [polypeptide binding]; other site 436717003503 conserved gate region; other site 436717003504 ABC-ATPase subunit interface; other site 436717003505 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 436717003506 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 436717003507 Walker A/P-loop; other site 436717003508 ATP binding site [chemical binding]; other site 436717003509 Q-loop/lid; other site 436717003510 ABC transporter signature motif; other site 436717003511 Walker B; other site 436717003512 D-loop; other site 436717003513 H-loop/switch region; other site 436717003514 NIL domain; Region: NIL; pfam09383 436717003515 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 436717003516 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 436717003517 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 436717003518 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 436717003519 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 436717003520 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 436717003521 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 436717003522 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 436717003523 purine monophosphate binding site [chemical binding]; other site 436717003524 dimer interface [polypeptide binding]; other site 436717003525 putative catalytic residues [active] 436717003526 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 436717003527 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 436717003528 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 436717003529 MJ0042 family finger-like domain; Region: MJ0042_CXXC; TIGR02098 436717003530 Protein of unknown function (DUF3426); Region: DUF3426; pfam11906 436717003531 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 436717003532 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 436717003533 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 436717003534 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 436717003535 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 436717003536 Predicted transcriptional regulator [Transcription]; Region: COG2378 436717003537 WYL domain; Region: WYL; pfam13280 436717003538 DnaQ family exonuclease/DinG family helicase, putative; Region: dinG_rel; TIGR01407 436717003539 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 436717003540 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 436717003541 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 436717003542 Predicted proteasome-type protease [Posttranslational modification, protein turnover, chaperones]; Region: COG3484 436717003543 Bacterial proteasome, beta subunit. The 20S proteasome, multisubunit proteolytic complex, is the central enzyme of nonlysosomal protein degradation in both the cytosol and nucleus. It is composed of 28 subunits arranged as four homoheptameric rings that...; Region: proteasome_beta_bacterial; cd03765 436717003544 Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787 436717003545 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827 436717003546 active site 436717003547 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 436717003548 substrate binding site [chemical binding]; other site 436717003549 catalytic residues [active] 436717003550 dimer interface [polypeptide binding]; other site 436717003551 replicative DNA helicase; Region: DnaB; TIGR00665 436717003552 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 436717003553 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 436717003554 Walker A motif; other site 436717003555 ATP binding site [chemical binding]; other site 436717003556 Walker B motif; other site 436717003557 DNA binding loops [nucleotide binding] 436717003558 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 436717003559 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 436717003560 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 436717003561 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 436717003562 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 436717003563 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 436717003564 UbiA prenyltransferase family; Region: UbiA; pfam01040 436717003565 cytochrome o ubiquinol oxidase subunit IV; Provisional; Region: PRK10582 436717003566 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 436717003567 Subunit I/III interface [polypeptide binding]; other site 436717003568 Subunit III/IV interface [polypeptide binding]; other site 436717003569 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 436717003570 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 436717003571 D-pathway; other site 436717003572 Putative ubiquinol binding site [chemical binding]; other site 436717003573 Low-spin heme (heme b) binding site [chemical binding]; other site 436717003574 Putative water exit pathway; other site 436717003575 Binuclear center (heme o3/CuB) [ion binding]; other site 436717003576 K-pathway; other site 436717003577 Putative proton exit pathway; other site 436717003578 cytochrome o ubiquinol oxidase subunit II; Region: CyoA; TIGR01433 436717003579 COX Aromatic Rich Motif; Region: COX_ARM; pfam06481 436717003580 Domain of unknown function (DUF4339); Region: DUF4339; pfam14237 436717003581 RDD family; Region: RDD; pfam06271 436717003582 phosphoenolpyruvate synthase; Validated; Region: PRK06464 436717003583 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 436717003584 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 436717003585 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 436717003586 PEP synthetase regulatory protein; Provisional; Region: PRK05339 436717003587 poly-beta-1,6 N-acetyl-D-glucosamine export porin PgaA; Region: PGA_TPR_OMP; TIGR03939 436717003588 poly-beta-1,6-N-acetyl-D-glucosamine N-deacetylase PgaB; Region: deacetyl_PgaB; TIGR03938 436717003589 N-terminal putative catalytic polysaccharide deacetylase domain of bacterial poly-beta-1,6-N-acetyl-D-glucosamine N-deacetylase PgaB, and similar proteins; Region: CE4_PgaB_5s; cd10964 436717003590 putative active site [active] 436717003591 putative metal binding site [ion binding]; other site 436717003592 N-glycosyltransferase; Provisional; Region: PRK11204 436717003593 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 436717003594 DXD motif; other site 436717003595 PgaD-like protein; Region: PgaD; pfam13994 436717003596 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 436717003597 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 436717003598 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 436717003599 peptide chain release factor 1; Validated; Region: prfA; PRK00591 436717003600 This domain is found in peptide chain release factors; Region: PCRF; smart00937 436717003601 RF-1 domain; Region: RF-1; pfam00472 436717003602 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 436717003603 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 436717003604 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 436717003605 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 436717003606 ABC-ATPase subunit interface; other site 436717003607 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 436717003608 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 436717003609 substrate binding pocket [chemical binding]; other site 436717003610 ABC transporter periplasmic binding protein, urea carboxylase region; Region: ABC_peri_uca; TIGR03427 436717003611 membrane-bound complex binding site; other site 436717003612 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 436717003613 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 436717003614 SurA N-terminal domain; Region: SurA_N; pfam09312 436717003615 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 436717003616 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08217 436717003617 17hydroxysteroid dehydrogenase type 10 (HSD10)-like, classical (c) SDRs; Region: HSD10-like_SDR_c; cd05371 436717003618 NAD binding site [chemical binding]; other site 436717003619 homodimer interface [polypeptide binding]; other site 436717003620 homotetramer interface [polypeptide binding]; other site 436717003621 active site 436717003622 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 436717003623 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 436717003624 active site 436717003625 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 436717003626 molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690 436717003627 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 436717003628 ATP binding site [chemical binding]; other site 436717003629 substrate interface [chemical binding]; other site 436717003630 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 436717003631 ABC1 family; Region: ABC1; cl17513 436717003632 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 436717003633 homooctamer interface [polypeptide binding]; other site 436717003634 active site 436717003635 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cl00233 436717003636 catalytic center binding site [active] 436717003637 ATP binding site [chemical binding]; other site 436717003638 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 436717003639 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 436717003640 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 436717003641 Soluble P-type ATPase [General function prediction only]; Region: COG4087 436717003642 potassium-transporting ATPase subunit C; Reviewed; Region: PRK00315 436717003643 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 436717003644 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 436717003645 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 436717003646 Ligand Binding Site [chemical binding]; other site 436717003647 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 436717003648 dimer interface [polypeptide binding]; other site 436717003649 phosphorylation site [posttranslational modification] 436717003650 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 436717003651 ATP binding site [chemical binding]; other site 436717003652 Mg2+ binding site [ion binding]; other site 436717003653 G-X-G motif; other site 436717003654 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 436717003655 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 436717003656 active site 436717003657 phosphorylation site [posttranslational modification] 436717003658 intermolecular recognition site; other site 436717003659 dimerization interface [polypeptide binding]; other site 436717003660 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 436717003661 DNA binding site [nucleotide binding] 436717003662 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 436717003663 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 436717003664 Protein of unknown function (DUF2799); Region: DUF2799; pfam10973 436717003665 Demethoxyubiquinone hydroxylase, ferritin-like diiron-binding domain; Region: DMQH; cd01042 436717003666 diiron binding motif [ion binding]; other site 436717003667 lysophospholipid transporter LplT; Provisional; Region: PRK11195 436717003668 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 436717003669 Surface antigen; Region: Bac_surface_Ag; pfam01103 436717003670 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911 436717003671 Family of unknown function (DUF490); Region: DUF490; pfam04357 436717003672 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 436717003673 bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238 436717003674 Aconitase B swivel domain. Aconitate hydratase B is involved in energy metabolism as part of the TCA cycle. It catalyses the formation of cis-aconitate from citrate. This is the aconitase swivel domain, which undergoes swivelling conformational change in...; Region: AcnB_Swivel; cd01576 436717003675 substrate binding site [chemical binding]; other site 436717003676 Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle; Region: AcnB; cd01581 436717003677 substrate binding site [chemical binding]; other site 436717003678 ligand binding site [chemical binding]; other site 436717003679 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 436717003680 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 436717003681 transmembrane helices; other site 436717003682 Ion transport protein; Region: Ion_trans; pfam00520 436717003683 Ion channel; Region: Ion_trans_2; pfam07885 436717003684 CCC1-related family of proteins; Region: CCC1_like; cl00278 436717003685 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 436717003686 putative substrate translocation pore; other site 436717003687 Major Facilitator Superfamily; Region: MFS_1; pfam07690 436717003688 Domain of unknown function (DUF4198); Region: DUF4198; pfam10670 436717003689 Transcriptional regulator [Transcription]; Region: LysR; COG0583 436717003690 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 436717003691 The C-terminal substrate binding domain of LysR-type transcriptional regulator metR, which regulates the expression of methionine biosynthetic genes, contains type 2 periplasmic binding fold; Region: PBP2_MetR; cd08441 436717003692 putative dimerization interface [polypeptide binding]; other site 436717003693 Protein of unknown function (DUF441); Region: DUF441; pfam04284 436717003694 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 436717003695 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 436717003696 RNA binding surface [nucleotide binding]; other site 436717003697 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 436717003698 active site 436717003699 uracil binding [chemical binding]; other site 436717003700 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 436717003701 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 436717003702 Coenzyme A binding pocket [chemical binding]; other site 436717003703 RelB antitoxin; Region: RelB; cl01171 436717003704 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 436717003705 Pseudouridine synthase, a subgroup of the RluA family; Region: PSRA_1; cd02558 436717003706 probable active site [active] 436717003707 Uncharacterized P-loop hydrolase UPF0079; Region: UPF0079; cl00520 436717003708 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 436717003709 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 436717003710 ATP binding site [chemical binding]; other site 436717003711 Mg2+ binding site [ion binding]; other site 436717003712 G-X-G motif; other site 436717003713 MutL_Trans_MutL: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to Escherichia coli MutL. EcMutL belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second...; Region: MutL_Trans_MutL; cd03482 436717003714 ATP binding site [chemical binding]; other site 436717003715 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 436717003716 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 436717003717 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 436717003718 bacterial Hfq-like; Region: Hfq; cd01716 436717003719 hexamer interface [polypeptide binding]; other site 436717003720 Sm1 motif; other site 436717003721 RNA binding site [nucleotide binding]; other site 436717003722 Sm2 motif; other site 436717003723 NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149 436717003724 dimer interface [polypeptide binding]; other site 436717003725 FMN binding site [chemical binding]; other site 436717003726 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 436717003727 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 436717003728 putative active site [active] 436717003729 putative metal binding site [ion binding]; other site 436717003730 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 436717003731 substrate binding site [chemical binding]; other site 436717003732 glutaminyl-tRNA synthetase; Provisional; Region: PRK05347 436717003733 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 436717003734 active site 436717003735 HIGH motif; other site 436717003736 nucleotide binding site [chemical binding]; other site 436717003737 catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807 436717003738 KMSKS motif; other site 436717003739 tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950 436717003740 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 436717003741 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 436717003742 catalytic triad [active] 436717003743 ethanolamine ammonia-lyase small subunit; Provisional; Region: PRK05465 436717003744 ethanolamine ammonia lyase large subunit; Provisional; Region: PRK15067 436717003745 Ethanolamine ammonia lyase large subunit (EutB); Region: EutB; pfam06751 436717003746 ethanolamine permease; Region: 2A0305; TIGR00908 436717003747 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 436717003748 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 436717003749 NAD(P) binding site [chemical binding]; other site 436717003750 catalytic residues [active] 436717003751 DNA-binding transcriptional activator of the SARP family [Signal transduction mechanisms]; Region: DnrI; COG3629 436717003752 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 436717003753 DNA binding site [nucleotide binding] 436717003754 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 436717003755 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 436717003756 Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176 436717003757 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 436717003758 dimer interface [polypeptide binding]; other site 436717003759 active site 436717003760 metal binding site [ion binding]; metal-binding site 436717003761 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 436717003762 PIF1-like helicase; Region: PIF1; pfam05970 436717003763 Walker A motif; other site 436717003764 ATP binding site [chemical binding]; other site 436717003765 Walker B motif; other site 436717003766 5-carboxymethyl-2-hydroxymuconate isomerase (CHMI) is a trimeric enzyme catalyzing the isomerization of the unsaturated ketone 5-(carboxymethyl)-2-hydroxymuconate to 5-(carboxymethyl)-2-oxo-3-hexene-1,6-dionate. This is one step in the...; Region: CHMI; cd00580 436717003767 putative substrate binding pocket [chemical binding]; other site 436717003768 trimer interface [polypeptide binding]; other site 436717003769 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 436717003770 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 436717003771 DNA gyrase inhibitor [DNA replication, recombination, and repair]; Region: COG3449 436717003772 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 436717003773 substrate binding site [chemical binding]; other site 436717003774 multimerization interface [polypeptide binding]; other site 436717003775 ATP binding site [chemical binding]; other site 436717003776 aminopeptidase N; Provisional; Region: pepN; PRK14015 436717003777 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_1; cd09600 436717003778 active site 436717003779 Zn binding site [ion binding]; other site 436717003780 Spore Coat Protein U domain; Region: SCPU; pfam05229 436717003781 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 436717003782 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 436717003783 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 436717003784 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 436717003785 PapC C-terminal domain; Region: PapC_C; pfam13953 436717003786 Spore Coat Protein U domain; Region: SCPU; pfam05229 436717003787 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 436717003788 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 436717003789 C-terminal domain interface [polypeptide binding]; other site 436717003790 GSH binding site (G-site) [chemical binding]; other site 436717003791 dimer interface [polypeptide binding]; other site 436717003792 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299 436717003793 N-terminal domain interface [polypeptide binding]; other site 436717003794 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 436717003795 NAD(P) binding site [chemical binding]; other site 436717003796 active site 436717003797 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 436717003798 active site 436717003799 chorismate mutase; Provisional; Region: PRK08055 436717003800 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 436717003801 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 436717003802 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 436717003803 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 436717003804 catalytic triad [active] 436717003805 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 436717003806 Gram-negative bacterial tonB protein; Region: TonB; cl10048 436717003807 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 436717003808 CoenzymeA binding site [chemical binding]; other site 436717003809 subunit interaction site [polypeptide binding]; other site 436717003810 PHB binding site; other site 436717003811 Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737 436717003812 catalytic residues [active] 436717003813 Uncharacterized conserved protein [Function unknown]; Region: COG2128 436717003814 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 436717003815 Predicted transcriptional regulators [Transcription]; Region: COG1733 436717003816 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 436717003817 putative DNA binding site [nucleotide binding]; other site 436717003818 dimerization interface [polypeptide binding]; other site 436717003819 putative Zn2+ binding site [ion binding]; other site 436717003820 Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072 436717003821 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 436717003822 EamA-like transporter family; Region: EamA; pfam00892 436717003823 Transcriptional regulator [Transcription]; Region: LysR; COG0583 436717003824 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 436717003825 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 436717003826 dimerization interface [polypeptide binding]; other site 436717003827 Bacterial OB fold (BOF) protein; Region: BOF; cl01196 436717003828 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 436717003829 Coenzyme A binding pocket [chemical binding]; other site 436717003830 Outer membrane protein W [Cell envelope biogenesis, outer membrane]; Region: OmpW; COG3047 436717003831 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 436717003832 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 436717003833 Walker A/P-loop; other site 436717003834 ATP binding site [chemical binding]; other site 436717003835 Q-loop/lid; other site 436717003836 ABC transporter signature motif; other site 436717003837 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 436717003838 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 436717003839 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 436717003840 Ligand Binding Site [chemical binding]; other site 436717003841 RDD family; Region: RDD; pfam06271 436717003842 Benzoate membrane transport protein; Region: BenE; pfam03594 436717003843 benzoate transporter; Region: benE; TIGR00843 436717003844 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 436717003845 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 436717003846 putative DNA binding site [nucleotide binding]; other site 436717003847 putative Zn2+ binding site [ion binding]; other site 436717003848 AsnC family; Region: AsnC_trans_reg; pfam01037 436717003849 leucine export protein LeuE; Provisional; Region: PRK10958 436717003850 transaldolase-like protein; Provisional; Region: PTZ00411 436717003851 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 436717003852 active site 436717003853 dimer interface [polypeptide binding]; other site 436717003854 catalytic residue [active] 436717003855 Transcriptional regulator [Transcription]; Region: LysR; COG0583 436717003856 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 436717003857 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 436717003858 dimerization interface [polypeptide binding]; other site 436717003859 Bacterial Transmembrane Pair family; Region: BTP; pfam05232 436717003860 Bacterial Transmembrane Pair family; Region: BTP; pfam05232 436717003861 acetyl-CoA acetyltransferase; Provisional; Region: PRK09268 436717003862 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 436717003863 dimer interface [polypeptide binding]; other site 436717003864 active site 436717003865 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08261 436717003866 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 436717003867 NAD(P) binding site [chemical binding]; other site 436717003868 active site 436717003869 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 436717003870 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 436717003871 active site 2 [active] 436717003872 active site 1 [active] 436717003873 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 436717003874 Beta-lactamase; Region: Beta-lactamase; pfam00144 436717003875 TetR family transcriptional regulator; Provisional; Region: PRK14996 436717003876 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 436717003877 methyl viologen resistance protein SmvA; Provisional; Region: PRK14995 436717003878 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 436717003879 Metallo-peptidase family M12B Reprolysin-like; Region: Reprolysin_3; pfam13582 436717003880 active site 436717003881 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14960 436717003882 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 436717003883 Walker A motif; other site 436717003884 ATP binding site [chemical binding]; other site 436717003885 Walker B motif; other site 436717003886 arginine finger; other site 436717003887 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 436717003888 phospholipase C, phosphocholine-specific, Pseudomonas-type; Region: PC_PLC; TIGR03396 436717003889 Phosphoesterase family; Region: Phosphoesterase; pfam04185 436717003890 Domain of unknown function (DUF756); Region: DUF756; pfam05506 436717003891 Domain of unknown function (DUF756); Region: DUF756; pfam05506 436717003892 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 436717003893 active site 436717003894 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 436717003895 5-hydroxyvalerate dehydrogenase (HVD) catalyzes the oxidation of 5-hydroxyvalerate to 5-oxovalerate with NAD+ as cofactor; Region: HVD; cd08193 436717003896 putative active site [active] 436717003897 metal binding site [ion binding]; metal-binding site 436717003898 Fels-1 Prophage Protein-like; Region: Fels1; pfam05666 436717003899 Fels-1 Prophage Protein-like; Region: Fels1; pfam05666 436717003900 Predicted transcriptional regulators [Transcription]; Region: COG1733 436717003901 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 436717003902 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 436717003903 active site 1 [active] 436717003904 dimer interface [polypeptide binding]; other site 436717003905 hexamer interface [polypeptide binding]; other site 436717003906 active site 2 [active] 436717003907 Low molecular weight phosphatase family; Region: LMWPc; cd00115 436717003908 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 436717003909 active site 436717003910 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK00046 436717003911 FAD binding domain; Region: FAD_binding_4; pfam01565 436717003912 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 436717003913 Uncharacterized conserved protein [Function unknown]; Region: COG1434 436717003914 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 436717003915 putative active site [active] 436717003916 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 436717003917 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 436717003918 Choloylglycine hydrolase (CGH) is a bile salt-modifying enzyme that hydrolyzes non-peptide carbon-nitrogen bonds in choloylglycine and choloyltaurine, both of which are present in bile. CGH is present in a number of probiotic microbial organisms that...; Region: Ntn_CGH; cd01902 436717003919 Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275 436717003920 Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069 436717003921 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 436717003922 active site 436717003923 FMN binding site [chemical binding]; other site 436717003924 substrate binding site [chemical binding]; other site 436717003925 3Fe-4S cluster binding site [ion binding]; other site 436717003926 DNA-binding transcriptional regulator AraC; Provisional; Region: PRK10572 436717003927 Spore Coat Protein U domain; Region: SCPU; pfam05229 436717003928 long polar fimbrial chaperone LpfB; Provisional; Region: PRK15208 436717003929 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 436717003930 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 436717003931 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 436717003932 PapC C-terminal domain; Region: PapC_C; pfam13953 436717003933 Spore Coat Protein U domain; Region: SCPU; pfam05229 436717003934 putative 3-phenylpropionic acid transporter; Provisional; Region: PRK11128 436717003935 MFS_1 like family; Region: MFS_1_like; pfam12832 436717003936 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 436717003937 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 436717003938 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 436717003939 ATP-grasp domain; Region: ATP-grasp_4; cl17255 436717003940 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 436717003941 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 436717003942 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 436717003943 carboxyltransferase (CT) interaction site; other site 436717003944 biotinylation site [posttranslational modification]; other site 436717003945 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 436717003946 Dehydroquinase class II; Region: DHquinase_II; pfam01220 436717003947 trimer interface [polypeptide binding]; other site 436717003948 active site 436717003949 dimer interface [polypeptide binding]; other site 436717003950 DNA polymerase V subunit UmuC; Reviewed; Region: umuC; PRK03609 436717003951 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 436717003952 active site 436717003953 DNA binding site [nucleotide binding] 436717003954 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 436717003955 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 436717003956 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 436717003957 N-terminal plug; other site 436717003958 ligand-binding site [chemical binding]; other site 436717003959 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase [Carbohydrate transport and metabolism]; Region: HpcH; COG3836 436717003960 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 436717003961 IucA / IucC family; Region: IucA_IucC; pfam04183 436717003962 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 436717003963 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 436717003964 IucA / IucC family; Region: IucA_IucC; pfam04183 436717003965 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 436717003966 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 436717003967 drug efflux system protein MdtG; Provisional; Region: PRK09874 436717003968 putative substrate translocation pore; other site 436717003969 IucA / IucC family; Region: IucA_IucC; pfam04183 436717003970 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 436717003971 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 436717003972 2,3-diaminopropionate biosynthesis protein SbnB; Region: dehyd_SbnB_fam; TIGR03944 436717003973 2,3-diaminopropionate biosynthesis protein SbnA; Region: PLP_SbnA_fam; TIGR03945 436717003974 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 436717003975 dimer interface [polypeptide binding]; other site 436717003976 pyridoxal 5'-phosphate binding site [chemical binding]; other site 436717003977 catalytic residue [active] 436717003978 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 436717003979 NMT1-like family; Region: NMT1_2; pfam13379 436717003980 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 436717003981 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 436717003982 active site 436717003983 phosphorylation site [posttranslational modification] 436717003984 intermolecular recognition site; other site 436717003985 dimerization interface [polypeptide binding]; other site 436717003986 ANTAR domain; Region: ANTAR; pfam03861 436717003987 nitrite reductase subunit NirD; Provisional; Region: PRK14989 436717003988 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 436717003989 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 436717003990 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 436717003991 Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529 436717003992 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 436717003993 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 436717003994 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 436717003995 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 436717003996 [4Fe-4S] binding site [ion binding]; other site 436717003997 molybdopterin cofactor binding site; other site 436717003998 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 436717003999 molybdopterin cofactor binding site; other site 436717004000 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 436717004001 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 436717004002 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 436717004003 GTP binding site; other site 436717004004 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 436717004005 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 436717004006 molybdopterin cofactor binding site; other site 436717004007 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 436717004008 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 436717004009 molybdopterin cofactor binding site; other site 436717004010 molybdenum cofactor biosynthesis protein A, bacterial; Region: moaA; TIGR02666 436717004011 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 436717004012 FeS/SAM binding site; other site 436717004013 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 436717004014 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 436717004015 MoaE homodimer interface [polypeptide binding]; other site 436717004016 MoaD interaction [polypeptide binding]; other site 436717004017 active site residues [active] 436717004018 bifunctional molybdenum cofactor biosynthesis protein MoaC/MogA; Provisional; Region: moaC; PRK03604 436717004019 MoaC family. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine derivative to the precursor...; Region: MoaC; cl00242 436717004020 trimer interface [polypeptide binding]; other site 436717004021 dimer interface [polypeptide binding]; other site 436717004022 putative active site [active] 436717004023 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 436717004024 MPT binding site; other site 436717004025 trimer interface [polypeptide binding]; other site 436717004026 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 436717004027 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 436717004028 dimer interface [polypeptide binding]; other site 436717004029 putative functional site; other site 436717004030 putative MPT binding site; other site 436717004031 Predicted transcriptional regulators [Transcription]; Region: COG1733 436717004032 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 436717004033 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 436717004034 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 436717004035 DNA-binding site [nucleotide binding]; DNA binding site 436717004036 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 436717004037 pyridoxal 5'-phosphate binding site [chemical binding]; other site 436717004038 homodimer interface [polypeptide binding]; other site 436717004039 catalytic residue [active] 436717004040 EamA-like transporter family; Region: EamA; pfam00892 436717004041 Dissimilatory sulfite reductase (desulfoviridin), gamma subunit [Inorganic ion transport and metabolism]; Region: DsrC; COG2920 436717004042 DsrC like protein; Region: DsrC; pfam04358 436717004043 DsrH like protein; Region: DsrH; cl17347 436717004044 sulfur relay protein TusD/DsrE; Region: sulf_tusD_dsrE; TIGR03012 436717004045 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 436717004046 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 436717004047 NAD(P) binding site [chemical binding]; other site 436717004048 active site 436717004049 fumarate hydratase; Reviewed; Region: fumC; PRK00485 436717004050 Class II fumarases; Region: Fumarase_classII; cd01362 436717004051 active site 436717004052 tetramer interface [polypeptide binding]; other site 436717004053 Isochorismatase family; Region: Isochorismatase; pfam00857 436717004054 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 436717004055 catalytic triad [active] 436717004056 conserved cis-peptide bond; other site 436717004057 D-amino acid dehydrogenase small subunit; Provisional; Region: PRK12409 436717004058 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 436717004059 hydroxyglutarate oxidase; Provisional; Region: PRK11728 436717004060 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 436717004061 homotrimer interaction site [polypeptide binding]; other site 436717004062 zinc binding site [ion binding]; other site 436717004063 CDP-binding sites; other site 436717004064 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 436717004065 active site 436717004066 catalytic residues [active] 436717004067 ornithine carbamoyltransferase; Provisional; Region: PRK00779 436717004068 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 436717004069 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 436717004070 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 436717004071 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 436717004072 AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246 436717004073 nitrogen regulation protein NR(I); Region: ntrC; TIGR01818 436717004074 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 436717004075 active site 436717004076 phosphorylation site [posttranslational modification] 436717004077 intermolecular recognition site; other site 436717004078 dimerization interface [polypeptide binding]; other site 436717004079 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 436717004080 Walker A motif; other site 436717004081 ATP binding site [chemical binding]; other site 436717004082 Walker B motif; other site 436717004083 arginine finger; other site 436717004084 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 436717004085 potential frameshift: common BLAST hit: gi|215483165|ref|YP_002325372.1| Nitrogen regulation protein ntrB 436717004086 ribosomal protein S12 methylthiotransferase; Provisional; Region: rimO; PRK14862 436717004087 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 436717004088 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 436717004089 FeS/SAM binding site; other site 436717004090 TRAM domain; Region: TRAM; cl01282 436717004091 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 436717004092 putative nucleotide binding site [chemical binding]; other site 436717004093 uridine monophosphate binding site [chemical binding]; other site 436717004094 homohexameric interface [polypeptide binding]; other site 436717004095 ribosome recycling factor; Reviewed; Region: frr; PRK00083 436717004096 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 436717004097 hinge region; other site 436717004098 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 436717004099 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 436717004100 catalytic residue [active] 436717004101 putative FPP diphosphate binding site; other site 436717004102 putative FPP binding hydrophobic cleft; other site 436717004103 dimer interface [polypeptide binding]; other site 436717004104 putative IPP diphosphate binding site; other site 436717004105 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 436717004106 CDP-diglyceride synthase; Provisional; Region: cdsA; PRK11624 436717004107 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 436717004108 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 436717004109 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 436717004110 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 436717004111 zinc metallopeptidase RseP; Provisional; Region: PRK10779 436717004112 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 436717004113 active site 436717004114 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 436717004115 protein binding site [polypeptide binding]; other site 436717004116 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 436717004117 protein binding site [polypeptide binding]; other site 436717004118 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 436717004119 putative substrate binding region [chemical binding]; other site 436717004120 outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303 436717004121 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 436717004122 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 436717004123 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 436717004124 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 436717004125 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 436717004126 Surface antigen; Region: Bac_surface_Ag; pfam01103 436717004127 Outer membrane protein (OmpH-like); Region: OmpH; pfam03938 436717004128 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 436717004129 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 436717004130 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 436717004131 trimer interface [polypeptide binding]; other site 436717004132 active site 436717004133 UDP-GlcNAc binding site [chemical binding]; other site 436717004134 lipid binding site [chemical binding]; lipid-binding site 436717004135 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 436717004136 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 436717004137 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 436717004138 active site 436717004139 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 436717004140 recombination regulator RecX; Reviewed; Region: recX; PRK00117 436717004141 recombinase A; Provisional; Region: recA; PRK09354 436717004142 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 436717004143 hexamer interface [polypeptide binding]; other site 436717004144 Walker A motif; other site 436717004145 ATP binding site [chemical binding]; other site 436717004146 Walker B motif; other site 436717004147 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 436717004148 RNA binding surface [nucleotide binding]; other site 436717004149 haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509 436717004150 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 436717004151 motif II; other site 436717004152 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 436717004153 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 436717004154 active site 436717004155 Int/Topo IB signature motif; other site 436717004156 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 436717004157 exodeoxyribonuclease X; Provisional; Region: PRK07983 436717004158 active site 436717004159 catalytic site [active] 436717004160 substrate binding site [chemical binding]; other site 436717004161 Protein of unknown function (DUF3820); Region: DUF3820; cl01411 436717004162 Uncharacterized conserved protein (DUF2303); Region: DUF2303; cl02338 436717004163 Cro/C1-type HTH DNA-binding domain; Region: HTH_26; pfam13443 436717004164 Predicted transcriptional regulator [Transcription]; Region: COG2932 436717004165 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 436717004166 Catalytic site [active] 436717004167 MarR family; Region: MarR_2; cl17246 436717004168 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 436717004169 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 436717004170 cofactor binding site; other site 436717004171 DNA binding site [nucleotide binding] 436717004172 substrate interaction site [chemical binding]; other site 436717004173 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 436717004174 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 436717004175 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 436717004176 Walker A motif; other site 436717004177 ATP binding site [chemical binding]; other site 436717004178 Walker B motif; other site 436717004179 arginine finger; other site 436717004180 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 436717004181 DNA methylase; Region: N6_N4_Mtase; pfam01555 436717004182 Endodeoxyribonuclease RusA; Region: RusA; pfam05866 436717004183 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 436717004184 non-specific DNA binding site [nucleotide binding]; other site 436717004185 salt bridge; other site 436717004186 sequence-specific DNA binding site [nucleotide binding]; other site 436717004187 Glycine zipper 2TM domain; Region: Rick_17kDa_Anti; pfam05433 436717004188 Arc-like DNA binding domain; Region: Arc; pfam03869 436717004189 P22_AR N-terminal domain; Region: P22_AR_N; pfam10547 436717004190 ORF6C domain; Region: ORF6C; pfam10552 436717004191 Tetratricopeptide repeat; Region: TPR_12; pfam13424 436717004192 Protein of unknown function (DUF2971); Region: DUF2971; pfam11185 436717004193 glutathione reductase; Validated; Region: PRK06116 436717004194 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 436717004195 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 436717004196 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 436717004197 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 436717004198 Major Facilitator Superfamily; Region: MFS_1; pfam07690 436717004199 putative substrate translocation pore; other site 436717004200 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 436717004201 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 436717004202 OsmC-like protein; Region: OsmC; pfam02566 436717004203 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 436717004204 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 436717004205 classical (c) SDRs; Region: SDR_c; cd05233 436717004206 NAD(P) binding site [chemical binding]; other site 436717004207 active site 436717004208 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 436717004209 catalytic residues [active] 436717004210 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 436717004211 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 436717004212 FMN binding site [chemical binding]; other site 436717004213 active site 436717004214 substrate binding site [chemical binding]; other site 436717004215 catalytic residue [active] 436717004216 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 436717004217 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 436717004218 catalytic residues [active] 436717004219 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 436717004220 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 436717004221 outer membrane porin L; Provisional; Region: ompL; PRK09980 436717004222 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 436717004223 Major Facilitator Superfamily; Region: MFS_1; pfam07690 436717004224 putative substrate translocation pore; other site 436717004225 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 436717004226 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 436717004227 transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393 436717004228 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 436717004229 conserved cys residue [active] 436717004230 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 436717004231 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 436717004232 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 436717004233 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 436717004234 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 436717004235 TonB dependent receptor; Region: TonB_dep_Rec; pfam00593 436717004236 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 436717004237 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 436717004238 N-terminal plug; other site 436717004239 ligand-binding site [chemical binding]; other site 436717004240 lipoprotein involved with copper homeostasis and adhesion; Provisional; Region: PRK10523 436717004241 Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; pfam09669 436717004242 Phage antirepressor protein KilAC domain; Region: ANT; pfam03374 436717004243 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 436717004244 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cl17442 436717004245 protein-splicing catalytic site; other site 436717004246 thioester formation/cholesterol transfer; other site 436717004247 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 436717004248 non-specific DNA binding site [nucleotide binding]; other site 436717004249 salt bridge; other site 436717004250 sequence-specific DNA binding site [nucleotide binding]; other site 436717004251 Toxin module HipA, protein kinase of phosphatidylinositol 3/4-kinase superfamily [General function prediction only]; Region: HipA; COG3550 436717004252 HipA-like N-terminal domain; Region: HipA_N; pfam07805 436717004253 HipA-like C-terminal domain; Region: HipA_C; pfam07804 436717004254 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 436717004255 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 436717004256 Domain of unknown function (DUF1983); Region: DUF1983; pfam09327 436717004257 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 436717004258 putative Mg++ binding site [ion binding]; other site 436717004259 Helicase_C-like; Region: Helicase_C_4; pfam13871 436717004260 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 436717004261 S-adenosylmethionine binding site [chemical binding]; other site 436717004262 TIGR02594 family protein; Region: TIGR02594 436717004263 extracellular lipase, Pla-1/cef family; Region: lipase_Pla1_cef; TIGR03502 436717004264 PAAR motif; Region: PAAR_motif; pfam05488 436717004265 DNA polymerase V subunit UmuC; Reviewed; Region: umuC; PRK03609 436717004266 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 436717004267 active site 436717004268 DNA binding site [nucleotide binding] 436717004269 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 436717004270 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 436717004271 Catalytic site [active] 436717004272 Bacteriophage abortive infection AbiH; Region: AbiH; pfam14253 436717004273 Uncharacterized ACR, COG2135; Region: DUF159; pfam02586 436717004274 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 436717004275 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 436717004276 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 436717004277 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 436717004278 putative DNA binding site [nucleotide binding]; other site 436717004279 putative Zn2+ binding site [ion binding]; other site 436717004280 AsnC family; Region: AsnC_trans_reg; pfam01037 436717004281 Kynureninase [Amino acid transport and metabolism]; Region: COG3844 436717004282 kynureninase; Region: kynureninase; TIGR01814 436717004283 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 436717004284 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 436717004285 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 436717004286 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 436717004287 Peptidase S8 family domain in ProteinaseK-like proteins; Region: Peptidases_S8_PCSK9_ProteinaseK_like; cd04077 436717004288 calcium binding site 2 [ion binding]; other site 436717004289 active site 436717004290 catalytic triad [active] 436717004291 calcium binding site 1 [ion binding]; other site 436717004292 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 436717004293 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 436717004294 Sulfate transporter family; Region: Sulfate_transp; pfam00916 436717004295 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 436717004296 Uncharacterized ACR, COG2135; Region: DUF159; pfam02586 436717004297 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 436717004298 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 436717004299 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 436717004300 Ligand Binding Site [chemical binding]; other site 436717004301 PAS fold; Region: PAS; pfam00989 436717004302 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 436717004303 putative active site [active] 436717004304 heme pocket [chemical binding]; other site 436717004305 PAS fold; Region: PAS_4; pfam08448 436717004306 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 436717004307 putative active site [active] 436717004308 heme pocket [chemical binding]; other site 436717004309 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 436717004310 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 436717004311 metal binding site [ion binding]; metal-binding site 436717004312 active site 436717004313 I-site; other site 436717004314 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 436717004315 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 436717004316 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 436717004317 putative DNA binding site [nucleotide binding]; other site 436717004318 putative Zn2+ binding site [ion binding]; other site 436717004319 PTS system fructose-specific transporter subunits IIBC; Provisional; Region: PRK10712 436717004320 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 436717004321 active site 436717004322 P-loop; other site 436717004323 phosphorylation site [posttranslational modification] 436717004324 PTS system, fructose subfamily, IIC component; Region: PTS_IIC_fructo; TIGR01427 436717004325 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 436717004326 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 436717004327 putative substrate binding site [chemical binding]; other site 436717004328 putative ATP binding site [chemical binding]; other site 436717004329 bifunctional PTS system fructose-specific transporter subunit IIA/HPr protein; Provisional; Region: PRK11109 436717004330 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 436717004331 active site 436717004332 phosphorylation site [posttranslational modification] 436717004333 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cl00163 436717004334 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 436717004335 dimerization domain swap beta strand [polypeptide binding]; other site 436717004336 regulatory protein interface [polypeptide binding]; other site 436717004337 active site 436717004338 regulatory phosphorylation site [posttranslational modification]; other site 436717004339 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 436717004340 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 436717004341 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 436717004342 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 436717004343 Predicted alpha/beta hydrolase [General function prediction only]; Region: COG4757 436717004344 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 436717004345 Domain of unknown function (DUF336); Region: DUF336; cl01249 436717004346 Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547 436717004347 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 436717004348 active site 436717004349 LysR family transcriptional regulator; Provisional; Region: PRK14997 436717004350 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 436717004351 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_4; cd08473 436717004352 putative effector binding pocket; other site 436717004353 putative dimerization interface [polypeptide binding]; other site 436717004354 Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028 436717004355 putative GSH binding site [chemical binding]; other site 436717004356 catalytic residues [active] 436717004357 acetylornithine aminotransferase; Provisional; Region: PRK02627 436717004358 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 436717004359 inhibitor-cofactor binding pocket; inhibition site 436717004360 pyridoxal 5'-phosphate binding site [chemical binding]; other site 436717004361 catalytic residue [active] 436717004362 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_10; cd04623 436717004363 FOG: CBS domain [General function prediction only]; Region: COG0517 436717004364 Protein of unknown function (DUF2750); Region: DUF2750; pfam11042 436717004365 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 436717004366 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 436717004367 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 436717004368 P loop; other site 436717004369 GTP binding site [chemical binding]; other site 436717004370 Nitroreductase-like family 4. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_4; cd02140 436717004371 dimer interface [polypeptide binding]; other site 436717004372 FMN binding site [chemical binding]; other site 436717004373 Uncharacterized protein conserved in bacteria (DUF2057); Region: DUF2057; pfam09829 436717004374 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 436717004375 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 436717004376 Coenzyme A binding pocket [chemical binding]; other site 436717004377 Cyd operon protein YbgE (Cyd_oper_YbgE); Region: Cyd_oper_YbgE; pfam09600 436717004378 Membrane bound YbgT-like protein; Region: YbgT_YccB; pfam08173 436717004379 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 436717004380 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 436717004381 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 436717004382 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562 436717004383 Protein of unknown function (DUF1449); Region: DUF1449; pfam07290 436717004384 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 436717004385 iron-sulfur cluster [ion binding]; other site 436717004386 [2Fe-2S] cluster binding site [ion binding]; other site 436717004387 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 436717004388 Adenosine kinase (AK) catalyzes the phosphorylation of ribofuranosyl-containing nucleoside analogues at the 5'-hydroxyl using ATP or GTP as the phosphate donor.The physiological function of AK is associated with the regulation of extracellular...; Region: adenosine_kinase; cd01168 436717004389 substrate binding site [chemical binding]; other site 436717004390 ATP binding site [chemical binding]; other site 436717004391 potential frameshift: common BLAST hit: gi|184158352|ref|YP_001846691.1| ferrichrome-iron receptor protein 436717004392 Predicted Zn-dependent peptidases, insulinase-like [General function prediction only]; Region: COG1026 436717004393 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 436717004394 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 436717004395 Peptidase M16C associated; Region: M16C_assoc; pfam08367 436717004396 Protein of unknown function (DUF3121); Region: DUF3121; cl11879 436717004397 The outer membrane phospholipase A (OMPLA) is an integral membrane enzyme that catalyses the hydrolysis of acylester bonds in phospholipids using calcium as a cofactor. The enzyme has a fold of transmembrane beta-barrels and is widespread among...; Region: OMPLA; cd00541 436717004398 dimerization interface [polypeptide binding]; other site 436717004399 substrate binding site [chemical binding]; other site 436717004400 active site 436717004401 calcium binding site [ion binding]; other site 436717004402 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 436717004403 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 436717004404 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 436717004405 TrkA-N domain; Region: TrkA_N; pfam02254 436717004406 threonine dehydratase; Reviewed; Region: PRK09224 436717004407 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 436717004408 tetramer interface [polypeptide binding]; other site 436717004409 pyridoxal 5'-phosphate binding site [chemical binding]; other site 436717004410 catalytic residue [active] 436717004411 First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906 436717004412 putative Ile/Val binding site [chemical binding]; other site 436717004413 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 436717004414 putative Ile/Val binding site [chemical binding]; other site 436717004415 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 436717004416 tetramer (dimer of dimers) interface [polypeptide binding]; other site 436717004417 active site 436717004418 dimer interface [polypeptide binding]; other site 436717004419 Protein of unknown function DUF45; Region: DUF45; pfam01863 436717004420 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 436717004421 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 436717004422 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 436717004423 Uncharacterized conserved protein [Function unknown]; Region: COG2127 436717004424 ATP-dependent Clp protease ATP-binding subunit clpA; Region: ClpA; TIGR02639 436717004425 Clp amino terminal domain; Region: Clp_N; pfam02861 436717004426 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 436717004427 Walker A motif; other site 436717004428 ATP binding site [chemical binding]; other site 436717004429 Walker B motif; other site 436717004430 arginine finger; other site 436717004431 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 436717004432 Walker A motif; other site 436717004433 ATP binding site [chemical binding]; other site 436717004434 Walker B motif; other site 436717004435 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 436717004436 hypothetical protein; Provisional; Region: PRK02237 436717004437 phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12755 436717004438 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 436717004439 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 436717004440 Predicted transcriptional regulators [Transcription]; Region: COG1695 436717004441 Transcriptional regulator PadR-like family; Region: PadR; cl17335 436717004442 Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400 436717004443 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 436717004444 2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930 436717004445 active site 436717004446 FMN binding site [chemical binding]; other site 436717004447 2,4-decadienoyl-CoA binding site; other site 436717004448 catalytic residue [active] 436717004449 4Fe-4S cluster binding site [ion binding]; other site 436717004450 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 436717004451 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 436717004452 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 436717004453 SnoaL-like domain; Region: SnoaL_2; pfam12680 436717004454 SGNH_hydrolase subfamily, FeeA, FeeB and similar esterases/lipases. FeeA and FeeB are part of a biosynthetic gene cluster and may participate in the biosynthesis of long-chain N-acyltyrosines by providing saturated and unsaturated fatty acids, which it...; Region: FeeA_FeeB_like; cd01836 436717004455 active site 436717004456 catalytic triad [active] 436717004457 oxyanion hole [active] 436717004458 Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; Region: COG0429 436717004459 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687 436717004460 Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118 436717004461 CTP synthetase; Validated; Region: pyrG; PRK05380 436717004462 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 436717004463 Catalytic site [active] 436717004464 active site 436717004465 UTP binding site [chemical binding]; other site 436717004466 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 436717004467 active site 436717004468 putative oxyanion hole; other site 436717004469 catalytic triad [active] 436717004470 2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198 436717004471 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 436717004472 enolase; Provisional; Region: eno; PRK00077 436717004473 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 436717004474 dimer interface [polypeptide binding]; other site 436717004475 metal binding site [ion binding]; metal-binding site 436717004476 substrate binding pocket [chemical binding]; other site 436717004477 Predicted membrane protein [Function unknown]; Region: COG2323 436717004478 Outer membrane receptor for ferric coprogen and ferric-rhodotorulic acid [Inorganic ion transport and metabolism]; Region: FhuE; COG4773 436717004479 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 436717004480 N-terminal plug; other site 436717004481 ligand-binding site [chemical binding]; other site 436717004482 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 436717004483 MarR family; Region: MarR_2; pfam12802 436717004484 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 436717004485 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 436717004486 Coenzyme A binding pocket [chemical binding]; other site 436717004487 Septum formation initiator; Region: DivIC; cl17659 436717004488 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 436717004489 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 436717004490 substrate binding site; other site 436717004491 dimer interface; other site 436717004492 3-oxoacid CoA-transferase, A subunit; Region: pcaI_scoA_fam; TIGR02429 436717004493 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 436717004494 beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050 436717004495 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 436717004496 dimer interface [polypeptide binding]; other site 436717004497 active site 436717004498 3-carboxy-cis,cis-muconate cycloisomerase; Provisional; Region: PRK09053 436717004499 prokaryotic 3-carboxy-cis,cis-muconate cycloisomerase (CMLE)_like; Region: pCLME; cd01597 436717004500 tetramer interface [polypeptide binding]; other site 436717004501 active site 436717004502 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 436717004503 TAP-like protein; Region: Abhydrolase_4; pfam08386 436717004504 benzoate transport; Region: 2A0115; TIGR00895 436717004505 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 436717004506 putative substrate translocation pore; other site 436717004507 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 436717004508 Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. This family contains catechol 1,2-dioxygenases and protocatechuate 3,4-dioxygenases which are mononuclear...; Region: intradiol_dioxygenase; cl17208 436717004509 protocatechuate 3,4-dioxygenase, beta subunit; Region: protocat_beta; TIGR02422 436717004510 active site 436717004511 Protocatechuate 3,4-dioxygenase beta subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PcaH; COG3485 436717004512 Protocatechuate 3,4-dioxygenase (3,4-PCD) , alpha subunit. 3,4-PCD catalyzes the oxidative ring cleavage of 3,4-dihydroxybenzoate to produce beta-carboxy-cis,cis-muconate. 3,4-PCDs are large aggregates of 12 protomers, each composed of an alpha- and...; Region: 3,4-PCD_alpha; cd03463 436717004513 heterodimer interface [polypeptide binding]; other site 436717004514 active site 436717004515 3-dehydroquinate dehydratase [Amino acid transport and metabolism]; Region: AroD; COG0710 436717004516 Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502 436717004517 active site 436717004518 catalytic residue [active] 436717004519 dimer interface [polypeptide binding]; other site 436717004520 Right handed beta helix region; Region: Beta_helix; pfam13229 436717004521 Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966 436717004522 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 436717004523 membrane-bound PQQ-dependent dehydrogenase, glucose/quinate/shikimate family; Region: PQQ_membr_DH; TIGR03074 436717004524 Membrane-bound PQQ-dependent glucose dehydrogenase; Region: PQQ_mGDH; cd10280 436717004525 Trp docking motif [polypeptide binding]; other site 436717004526 putative active site [active] 436717004527 Predicted transporter component [General function prediction only]; Region: COG2391 436717004528 Domain of unknown function (DUF4341); Region: DUF4341; pfam14241 436717004529 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 436717004530 beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Region: pcaR_pcaU; TIGR02431 436717004531 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 436717004532 Bacterial transcriptional regulator; Region: IclR; pfam01614 436717004533 Transcriptional regulator [Transcription]; Region: LysR; COG0583 436717004534 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 436717004535 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 436717004536 substrate binding pocket [chemical binding]; other site 436717004537 dimerization interface [polypeptide binding]; other site 436717004538 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 436717004539 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 436717004540 active site 436717004541 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 436717004542 putative active site [active] 436717004543 putative substrate binding site [chemical binding]; other site 436717004544 ATP binding site [chemical binding]; other site 436717004545 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 436717004546 catalytic core [active] 436717004547 short chain dehydrogenase; Provisional; Region: PRK08251 436717004548 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 436717004549 NAD(P) binding site [chemical binding]; other site 436717004550 active site 436717004551 outer membrane porin, OprD family; Region: OprD; pfam03573 436717004552 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 436717004553 Major Facilitator Superfamily; Region: MFS_1; pfam07690 436717004554 putative substrate translocation pore; other site 436717004555 Transcriptional regulators [Transcription]; Region: MarR; COG1846 436717004556 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 436717004557 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 436717004558 Amidase; Region: Amidase; cl11426 436717004559 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 436717004560 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 436717004561 active site 436717004562 SnoaL-like domain; Region: SnoaL_4; pfam13577 436717004563 benzoate 1,2-dioxygenase, large subunit; Region: benzo_1_2_benA; TIGR03229 436717004564 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 436717004565 [2Fe-2S] cluster binding site [ion binding]; other site 436717004566 C-terminal catalytic domain of the oxygenase alpha subunit of Pseudomonas resinovorans strain CA10 anthranilate 1,2-dioxygenase and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_AntDO-like; cd08879 436717004567 putative alpha subunit interface [polypeptide binding]; other site 436717004568 putative active site [active] 436717004569 putative substrate binding site [chemical binding]; other site 436717004570 Fe binding site [ion binding]; other site 436717004571 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 436717004572 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 436717004573 classical (c) SDRs; Region: SDR_c; cd05233 436717004574 NAD(P) binding site [chemical binding]; other site 436717004575 active site 436717004576 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 436717004577 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 436717004578 FMN-binding pocket [chemical binding]; other site 436717004579 flavin binding motif; other site 436717004580 phosphate binding motif [ion binding]; other site 436717004581 beta-alpha-beta structure motif; other site 436717004582 NAD binding pocket [chemical binding]; other site 436717004583 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 436717004584 catalytic loop [active] 436717004585 iron binding site [ion binding]; other site 436717004586 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 436717004587 DNA-binding transcriptional activator FeaR; Provisional; Region: PRK09685 436717004588 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 436717004589 tyramine oxidase; Provisional; Region: tynA; PRK14696 436717004590 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 436717004591 Copper amine oxidase, N3 domain; Region: Cu_amine_oxidN3; pfam02728 436717004592 Copper amine oxidase, enzyme domain; Region: Cu_amine_oxid; pfam01179 436717004593 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 436717004594 choline dehydrogenase; Validated; Region: PRK02106 436717004595 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 436717004596 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 436717004597 Escherichia coli NAD+-dependent phenylacetaldehyde dehydrogenase PadA-like; Region: ALDH_PADH_NahF; cd07113 436717004598 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 436717004599 NAD(P) binding site [chemical binding]; other site 436717004600 catalytic residues [active] 436717004601 Protein related to penicillin acylase [General function prediction only]; Region: COG2366 436717004602 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 436717004603 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 436717004604 active site 436717004605 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 436717004606 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 436717004607 beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050 436717004608 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 436717004609 dimer interface [polypeptide binding]; other site 436717004610 active site 436717004611 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 436717004612 3-oxoacid CoA-transferase, A subunit; Region: pcaI_scoA_fam; TIGR02429 436717004613 catechol 1,2-dioxygenase, proteobacterial; Region: catechol_proteo; TIGR02439 436717004614 Catechol 1,2 dioxygenase (1,2-CTD) catalyzes an intradiol cleavage reaction of catechol to form cis,cis-muconate. 1,2-CTDs is homodimers with one catalytic non-heme ferric ion per monomer. They belong to the aromatic dioxygenase family, a family of...; Region: 1,2-CTD; cd03460 436717004615 dimer interface [polypeptide binding]; other site 436717004616 active site 436717004617 muconolactone delta-isomerase; Region: muco_delta; TIGR03221 436717004618 muconate and chloromuconate cycloisomerases; Region: mucon_cyclo; TIGR02534 436717004619 Muconate Lactonizing Enzyme (MLE), an homooctameric enzyme, catalyses the conversion of cis,cis-muconate (CCM) to muconolactone (ML) in the catechol branch of the beta-ketoadipate pathway. This pathway is used in soil microbes to breakdown lignin-derived...; Region: MLE; cd03318 436717004620 octamer interface [polypeptide binding]; other site 436717004621 active site 436717004622 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 436717004623 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 436717004624 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 436717004625 dimerization interface [polypeptide binding]; other site 436717004626 Bacterial protein of unknown function (Gcw_chp); Region: Gcw_chp; pfam09694 436717004627 Transcriptional regulator [Transcription]; Region: LysR; COG0583 436717004628 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 436717004629 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 436717004630 dimerization interface [polypeptide binding]; other site 436717004631 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 436717004632 alkanesulfonate monooxygenase, FMNH(2)-dependent; Region: alk_sulf_monoox; TIGR03565 436717004633 dimer interface [polypeptide binding]; other site 436717004634 active site 436717004635 non-prolyl cis peptide bond; other site 436717004636 insertion regions; other site 436717004637 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 436717004638 substrate binding pocket [chemical binding]; other site 436717004639 membrane-bound complex binding site; other site 436717004640 hinge residues; other site 436717004641 Predicted metal-dependent enzyme of the double-stranded beta helix superfamily [General function prediction only]; Region: COG5553 436717004642 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 436717004643 active site residue [active] 436717004644 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 436717004645 active site residue [active] 436717004646 Member of the Rhodanese Homology Domain superfamily, repeat 3. This CD includes putative rhodanese-related sulfurtransferases which contain 4 copies of the Rhodanese Homology Domain. This CD aligns the 3rd repeat which does not contain the putative...; Region: 4RHOD_Repeat_3; cd01534 436717004647 active site residue [active] 436717004648 Member of the Rhodanese Homology Domain superfamily, repeat 4. This CD includes putative rhodanese-related sulfurtransferases which contain 4 copies of the Rhodanese Homology Domain. This CD aligns the 4th repeat which, in general, contains the putative...; Region: 4RHOD_Repeat_4; cd01535 436717004649 active site residue [active] 436717004650 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 436717004651 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 436717004652 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 436717004653 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 436717004654 Walker A/P-loop; other site 436717004655 ATP binding site [chemical binding]; other site 436717004656 Q-loop/lid; other site 436717004657 ABC transporter signature motif; other site 436717004658 Walker B; other site 436717004659 D-loop; other site 436717004660 H-loop/switch region; other site 436717004661 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 436717004662 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 436717004663 TM-ABC transporter signature motif; other site 436717004664 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 436717004665 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 436717004666 TM-ABC transporter signature motif; other site 436717004667 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_1; cd06334 436717004668 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 436717004669 putative ligand binding site [chemical binding]; other site 436717004670 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 436717004671 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 436717004672 Walker A/P-loop; other site 436717004673 ATP binding site [chemical binding]; other site 436717004674 Q-loop/lid; other site 436717004675 ABC transporter signature motif; other site 436717004676 Walker B; other site 436717004677 D-loop; other site 436717004678 H-loop/switch region; other site 436717004679 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 436717004680 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 436717004681 Walker A motif; other site 436717004682 ATP binding site [chemical binding]; other site 436717004683 Walker B motif; other site 436717004684 arginine finger; other site 436717004685 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 436717004686 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 436717004687 Dibenzothiophene (DBT) desulfurization enzyme C; Region: DszC; cd01163 436717004688 Flavin binding site [chemical binding]; other site 436717004689 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 436717004690 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 436717004691 Walker A motif; other site 436717004692 ATP binding site [chemical binding]; other site 436717004693 Walker B motif; other site 436717004694 arginine finger; other site 436717004695 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 436717004696 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 436717004697 classical (c) SDRs; Region: SDR_c; cd05233 436717004698 NAD(P) binding site [chemical binding]; other site 436717004699 active site 436717004700 beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Region: pcaR_pcaU; TIGR02431 436717004701 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 436717004702 Bacterial transcriptional regulator; Region: IclR; pfam01614 436717004703 putative succinate dehydrogenase; Reviewed; Region: PRK12842 436717004704 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 436717004705 Predicted oxidoreductase [General function prediction only]; Region: COG3573 436717004706 NIPSNAP; Region: NIPSNAP; pfam07978 436717004707 benzoate transport; Region: 2A0115; TIGR00895 436717004708 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 436717004709 putative substrate translocation pore; other site 436717004710 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 436717004711 putative substrate translocation pore; other site 436717004712 Carbohydrate-selective porin, OprB family; Region: OprB; cl17816 436717004713 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 436717004714 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 436717004715 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 436717004716 Major Facilitator Superfamily; Region: MFS_1; pfam07690 436717004717 Transcriptional regulator [Transcription]; Region: IclR; COG1414 436717004718 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 436717004719 Bacterial transcriptional regulator; Region: IclR; pfam01614 436717004720 benzoate transport; Region: 2A0115; TIGR00895 436717004721 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 436717004722 putative substrate translocation pore; other site 436717004723 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 436717004724 shikimate 5-dehydrogenase; Provisional; Region: PRK12548 436717004725 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 436717004726 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 436717004727 shikimate binding site; other site 436717004728 NAD(P) binding site [chemical binding]; other site 436717004729 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 436717004730 putative FAD-binding dehydrogenase; Reviewed; Region: PRK06134 436717004731 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 436717004732 Predicted oxidoreductase [General function prediction only]; Region: COG3573 436717004733 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12843 436717004734 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 436717004735 NIPSNAP; Region: NIPSNAP; pfam07978 436717004736 NIPSNAP; Region: NIPSNAP; pfam07978 436717004737 Acetoacetate decarboxylase (ADC); Region: ADC; cl01919 436717004738 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 436717004739 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 436717004740 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 436717004741 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 436717004742 Old yellow enzyme (OYE)-related FMN binding domain, group 2. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_2_FMN; cd04733 436717004743 putative active site [active] 436717004744 putative FMN binding site [chemical binding]; other site 436717004745 putative substrate binding site [chemical binding]; other site 436717004746 putative catalytic residue [active] 436717004747 Uncharacterized conserved protein [Function unknown]; Region: COG3268 436717004748 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 436717004749 NAD(P) binding site [chemical binding]; other site 436717004750 RibD C-terminal domain; Region: RibD_C; cl17279 436717004751 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 436717004752 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 436717004753 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 436717004754 potential catalytic triad [active] 436717004755 conserved cys residue [active] 436717004756 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 436717004757 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 436717004758 DNA binding residues [nucleotide binding] 436717004759 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 436717004760 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 436717004761 potential catalytic triad [active] 436717004762 conserved cys residue [active] 436717004763 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 436717004764 Predicted transcriptional regulator [Transcription]; Region: COG1959 436717004765 Transcriptional regulator; Region: Rrf2; pfam02082 436717004766 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 436717004767 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 436717004768 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 436717004769 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 436717004770 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 436717004771 Helix-turn-helix domain; Region: HTH_18; pfam12833 436717004772 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 436717004773 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 436717004774 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 436717004775 NAD(P) binding site [chemical binding]; other site 436717004776 active site 436717004777 Acetoacetate decarboxylase (ADC); Region: ADC; pfam06314 436717004778 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687 436717004779 Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118 436717004780 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 436717004781 Old yellow enzyme (OYE)-related FMN binding domain, group 2. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_2_FMN; cd04733 436717004782 putative active site [active] 436717004783 putative FMN binding site [chemical binding]; other site 436717004784 putative substrate binding site [chemical binding]; other site 436717004785 putative catalytic residue [active] 436717004786 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687 436717004787 Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118 436717004788 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 436717004789 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 436717004790 putative NAD(P) binding site [chemical binding]; other site 436717004791 short chain dehydrogenase; Provisional; Region: PRK06179 436717004792 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 436717004793 NADP binding site [chemical binding]; other site 436717004794 active site 436717004795 steroid binding site; other site 436717004796 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 436717004797 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 436717004798 WHG domain; Region: WHG; pfam13305 436717004799 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 436717004800 substrate binding site [chemical binding]; other site 436717004801 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 436717004802 oxyanion hole (OAH) forming residues; other site 436717004803 trimer interface [polypeptide binding]; other site 436717004804 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 436717004805 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 436717004806 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 436717004807 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 436717004808 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 436717004809 acyl-activating enzyme (AAE) consensus motif; other site 436717004810 putative AMP binding site [chemical binding]; other site 436717004811 putative active site [active] 436717004812 putative CoA binding site [chemical binding]; other site 436717004813 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 436717004814 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 436717004815 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 436717004816 TAP-like protein; Region: Abhydrolase_4; pfam08386 436717004817 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 436717004818 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 436717004819 TAP-like protein; Region: Abhydrolase_4; pfam08386 436717004820 Old yellow enzyme (OYE)-related FMN binding domain, group 2. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_2_FMN; cd04733 436717004821 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 436717004822 putative active site [active] 436717004823 putative FMN binding site [chemical binding]; other site 436717004824 putative substrate binding site [chemical binding]; other site 436717004825 putative catalytic residue [active] 436717004826 Predicted transcriptional regulators [Transcription]; Region: COG1733 436717004827 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 436717004828 Predicted transcriptional regulators [Transcription]; Region: COG1733 436717004829 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 436717004830 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 436717004831 triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269 436717004832 NADP binding site [chemical binding]; other site 436717004833 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 436717004834 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 436717004835 Gram-negative bacterial tonB protein; Region: TonB; cl10048 436717004836 Outer membrane protein W [Cell envelope biogenesis, outer membrane]; Region: OmpW; COG3047 436717004837 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 436717004838 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 436717004839 WHG domain; Region: WHG; pfam13305 436717004840 Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670 436717004841 Retinal pigment epithelial membrane protein; Region: RPE65; pfam03055 436717004842 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 436717004843 Transcriptional regulator [Transcription]; Region: IclR; COG1414 436717004844 Bacterial transcriptional regulator; Region: IclR; pfam01614 436717004845 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 436717004846 Major Facilitator Superfamily; Region: MFS_1; pfam07690 436717004847 putative substrate translocation pore; other site 436717004848 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 436717004849 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 436717004850 ligand binding site [chemical binding]; other site 436717004851 NAD binding site [chemical binding]; other site 436717004852 dimerization interface [polypeptide binding]; other site 436717004853 catalytic site [active] 436717004854 hypothetical protein; Validated; Region: PRK06201 436717004855 Demethylmenaquinone methyltransferase [Coenzyme metabolism]; Region: MenG; COG0684 436717004856 Antitoxin of toxin-antitoxin stability system N-terminal; Region: RelB_N; pfam12910 436717004857 RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931 436717004858 type I secretion C-terminal target domain (VC_A0849 subclass); Region: T1SS_VCA0849; TIGR03661 436717004859 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 436717004860 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 436717004861 Haemolysin secretion/activation protein ShlB/FhaC/HecB; Region: ShlB; pfam03865 436717004862 haemagglutination activity domain; Region: Haemagg_act; pfam05860 436717004863 Possible hemagglutinin (DUF637); Region: DUF637; pfam04830 436717004864 Pre-toxin domain with VENN motif; Region: PT-VENN; pfam04829 436717004865 DNase/tRNase domain of colicin-like bacteriocin; Region: Colicin-DNase; pfam12639 436717004866 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 436717004867 Transcriptional regulator [Transcription]; Region: LysR; COG0583 436717004868 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 436717004869 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 436717004870 dimerization interface [polypeptide binding]; other site 436717004871 beta alanine--pyruvate transaminase; Provisional; Region: PRK09221 436717004872 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 436717004873 inhibitor-cofactor binding pocket; inhibition site 436717004874 pyridoxal 5'-phosphate binding site [chemical binding]; other site 436717004875 catalytic residue [active] 436717004876 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 436717004877 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 436717004878 tetrameric interface [polypeptide binding]; other site 436717004879 NAD binding site [chemical binding]; other site 436717004880 catalytic residues [active] 436717004881 gamma-aminobutyrate permease; Region: GABAperm; TIGR01773 436717004882 Transcriptional regulator [Transcription]; Region: LysR; COG0583 436717004883 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 436717004884 The C-terminal substrate binding domain of LysR-type transcriptional regulators that are involved in the catabolism of dinitrotoluene, naphthalene and gamma-hexachlorohexane; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_NahR_LinR_like; cd08459 436717004885 substrate binding pocket [chemical binding]; other site 436717004886 dimerization interface [polypeptide binding]; other site 436717004887 Gentisate 1,2-dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3435 436717004888 Cupin domain; Region: Cupin_2; pfam07883 436717004889 salicylate hydroxylase; Provisional; Region: PRK08163 436717004890 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 436717004891 GST_N family, Class Zeta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Zeta; cd03042 436717004892 maleylacetoacetate isomerase; Region: maiA; TIGR01262 436717004893 C-terminal domain interface [polypeptide binding]; other site 436717004894 GSH binding site (G-site) [chemical binding]; other site 436717004895 putative dimer interface [polypeptide binding]; other site 436717004896 C-terminal, alpha helical domain of Class Zeta Glutathione S-transferases; Region: GST_C_Zeta; cd03191 436717004897 dimer interface [polypeptide binding]; other site 436717004898 N-terminal domain interface [polypeptide binding]; other site 436717004899 maleylacetoacetate (MAA) substrate binding site (H site) [chemical binding]; other site 436717004900 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 436717004901 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 436717004902 benzoate transport; Region: 2A0115; TIGR00895 436717004903 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 436717004904 putative substrate translocation pore; other site 436717004905 outer membrane porin, OprD family; Region: OprD; pfam03573 436717004906 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 436717004907 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 436717004908 E3 interaction surface; other site 436717004909 lipoyl attachment site [posttranslational modification]; other site 436717004910 HlyD family secretion protein; Region: HlyD_3; pfam13437 436717004911 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 436717004912 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 436717004913 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 436717004914 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 436717004915 AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246 436717004916 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 436717004917 Alpha-Ketoglutaric Semialdehyde Dehydrogenase; Region: ALDH_KGSADH; cd07129 436717004918 dimer interface [polypeptide binding]; other site 436717004919 NADP binding site [chemical binding]; other site 436717004920 catalytic residues [active] 436717004921 dihydroxy-acid dehydratase; Provisional; Region: PRK13017 436717004922 Fumarylacetoacetate (FAA) hydrolase family protein [General function prediction only]; Region: COG3970 436717004923 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 436717004924 Transcriptional regulator [Transcription]; Region: LysR; COG0583 436717004925 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 436717004926 The C-terminal substrate binding domain of galactose-binding protein regulator contains the type 2 periplasmic binding fold; Region: PBP2_GbpR; cd08435 436717004927 putative dimerization interface [polypeptide binding]; other site 436717004928 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 436717004929 Escherichia coli Gne (a nucleoside-diphosphate-sugar 4-epimerase)-like, extended (e) SDRs; Region: Gne_like_SDR_e; cd05238 436717004930 putative NAD(P) binding site [chemical binding]; other site 436717004931 active site 436717004932 putative substrate binding site [chemical binding]; other site 436717004933 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 436717004934 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 436717004935 putative substrate translocation pore; other site 436717004936 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 436717004937 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 436717004938 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 436717004939 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 436717004940 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 436717004941 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 436717004942 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 436717004943 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 436717004944 putative NAD(P) binding site [chemical binding]; other site 436717004945 putative substrate binding site [chemical binding]; other site 436717004946 catalytic Zn binding site [ion binding]; other site 436717004947 structural Zn binding site [ion binding]; other site 436717004948 dimer interface [polypeptide binding]; other site 436717004949 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 436717004950 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 436717004951 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 436717004952 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 436717004953 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 436717004954 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 436717004955 intersubunit interface [polypeptide binding]; other site 436717004956 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 436717004957 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 436717004958 ABC-ATPase subunit interface; other site 436717004959 dimer interface [polypeptide binding]; other site 436717004960 putative PBP binding regions; other site 436717004961 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 436717004962 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 436717004963 Walker A/P-loop; other site 436717004964 ATP binding site [chemical binding]; other site 436717004965 Q-loop/lid; other site 436717004966 ABC transporter signature motif; other site 436717004967 Walker B; other site 436717004968 D-loop; other site 436717004969 H-loop/switch region; other site 436717004970 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 436717004971 Coenzyme A binding pocket [chemical binding]; other site 436717004972 Cupin domain; Region: Cupin_2; cl17218 436717004973 Helix-turn-helix domain; Region: HTH_18; pfam12833 436717004974 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 436717004975 Phosphoribosylpyrophosphate synthetase [Nucleotide transport and metabolism / Amino acid transport and metabolism]; Region: PrsA; COG0462 436717004976 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 436717004977 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 436717004978 active site 436717004979 putative nicotinate phosphoribosyltransferase; Provisional; Region: PRK09198 436717004980 pre-B-cell colony-enhancing factor (PBEF)-like. The mammalian members of this group of nicotinate phosphoribosyltransferases (NAPRTases) were originally identified as genes whose expression is upregulated upon activation in lymphoid cells. In general; Region: PBEF_like; cd01569 436717004981 active site 436717004982 ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051 436717004983 nudix motif; other site 436717004984 Uncharacterized conserved protein [General function prediction only]; Region: COG4111 436717004985 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cl00246 436717004986 FAD binding site [chemical binding]; other site 436717004987 Methylene-tetrahydrofolate reductase C terminal; Region: MTHFR_C; pfam12225 436717004988 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 436717004989 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 436717004990 DNA binding residues [nucleotide binding] 436717004991 dimerization interface [polypeptide binding]; other site 436717004992 indole acetimide hydrolase; Validated; Region: PRK07488 436717004993 Amidase; Region: Amidase; pfam01425 436717004994 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 436717004995 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 436717004996 HlyD family secretion protein; Region: HlyD_3; pfam13437 436717004997 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 436717004998 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 436717004999 putative substrate translocation pore; other site 436717005000 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 436717005001 GH3 auxin-responsive promoter; Region: GH3; pfam03321 436717005002 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 436717005003 Survival protein SurE; Region: SurE; pfam01975 436717005004 HD domain; Region: HD_4; pfam13328 436717005005 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 436717005006 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 436717005007 PAAR motif; Region: PAAR_motif; pfam05488 436717005008 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 436717005009 Transcriptional regulator [Transcription]; Region: IclR; COG1414 436717005010 Bacterial transcriptional regulator; Region: IclR; pfam01614 436717005011 H+/citrate symporter [Energy production and conversion]; Region: CitM; COG2851 436717005012 Citrate transporter; Region: CitMHS; pfam03600 436717005013 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 436717005014 active site 436717005015 catalytic residues [active] 436717005016 metal binding site [ion binding]; metal-binding site 436717005017 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 436717005018 CoA-transferase family III; Region: CoA_transf_3; pfam02515 436717005019 HipA-like N-terminal domain; Region: HipA_N; pfam07805 436717005020 HipA-like C-terminal domain; Region: HipA_C; pfam07804 436717005021 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 436717005022 non-specific DNA binding site [nucleotide binding]; other site 436717005023 salt bridge; other site 436717005024 sequence-specific DNA binding site [nucleotide binding]; other site 436717005025 Isochorismatase family; Region: Isochorismatase; pfam00857 436717005026 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 436717005027 catalytic triad [active] 436717005028 dimer interface [polypeptide binding]; other site 436717005029 conserved cis-peptide bond; other site 436717005030 Phospholipase/Carboxylesterase; Region: Abhydrolase_2; pfam02230 436717005031 putative hydrolase; Provisional; Region: PRK11460 436717005032 Predicted membrane protein [Function unknown]; Region: COG2259 436717005033 Transcriptional regulator [Transcription]; Region: LysR; COG0583 436717005034 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 436717005035 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 436717005036 putative effector binding pocket; other site 436717005037 dimerization interface [polypeptide binding]; other site 436717005038 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 436717005039 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 436717005040 dimerization interface [polypeptide binding]; other site 436717005041 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 436717005042 dimer interface [polypeptide binding]; other site 436717005043 phosphorylation site [posttranslational modification] 436717005044 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 436717005045 ATP binding site [chemical binding]; other site 436717005046 Mg2+ binding site [ion binding]; other site 436717005047 G-X-G motif; other site 436717005048 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 436717005049 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 436717005050 active site 436717005051 phosphorylation site [posttranslational modification] 436717005052 intermolecular recognition site; other site 436717005053 dimerization interface [polypeptide binding]; other site 436717005054 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 436717005055 DNA binding site [nucleotide binding] 436717005056 multidrug efflux system transporter AcrA; Provisional; Region: PRK15030 436717005057 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 436717005058 HlyD family secretion protein; Region: HlyD_3; pfam13437 436717005059 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 436717005060 Protein export membrane protein; Region: SecD_SecF; cl14618 436717005061 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 436717005062 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 436717005063 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 436717005064 benzoate transport; Region: 2A0115; TIGR00895 436717005065 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 436717005066 putative substrate translocation pore; other site 436717005067 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 436717005068 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 436717005069 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 436717005070 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 436717005071 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 436717005072 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 436717005073 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 436717005074 NAD(P) binding pocket [chemical binding]; other site 436717005075 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 436717005076 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 436717005077 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 436717005078 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 436717005079 Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; cl17479 436717005080 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 436717005081 Walker A/P-loop; other site 436717005082 ATP binding site [chemical binding]; other site 436717005083 Q-loop/lid; other site 436717005084 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 436717005085 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 436717005086 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 436717005087 Walker A/P-loop; other site 436717005088 ATP binding site [chemical binding]; other site 436717005089 Q-loop/lid; other site 436717005090 ABC transporter signature motif; other site 436717005091 Walker B; other site 436717005092 D-loop; other site 436717005093 H-loop/switch region; other site 436717005094 Uncharacterized conserved protein (DUF2132); Region: DUF2132; pfam09905 436717005095 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 436717005096 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 436717005097 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 436717005098 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 436717005099 active site 436717005100 iron coordination sites [ion binding]; other site 436717005101 substrate binding pocket [chemical binding]; other site 436717005102 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 436717005103 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 436717005104 ligand binding site [chemical binding]; other site 436717005105 flexible hinge region; other site 436717005106 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 436717005107 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 436717005108 Sulfatase; Region: Sulfatase; pfam00884 436717005109 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 436717005110 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 436717005111 N-terminal plug; other site 436717005112 ligand-binding site [chemical binding]; other site 436717005113 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 436717005114 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 436717005115 active site 436717005116 catalytic tetrad [active] 436717005117 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 436717005118 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 436717005119 active site 436717005120 non-prolyl cis peptide bond; other site 436717005121 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 436717005122 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 436717005123 N-terminal plug; other site 436717005124 ligand-binding site [chemical binding]; other site 436717005125 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 436717005126 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 436717005127 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 436717005128 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 436717005129 active site 436717005130 iron coordination sites [ion binding]; other site 436717005131 substrate binding pocket [chemical binding]; other site 436717005132 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 436717005133 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 436717005134 ligand binding site [chemical binding]; other site 436717005135 flexible hinge region; other site 436717005136 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 436717005137 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 436717005138 TolR protein; Region: tolR; TIGR02801 436717005139 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 436717005140 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 436717005141 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 436717005142 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 436717005143 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 436717005144 Walker A/P-loop; other site 436717005145 ATP binding site [chemical binding]; other site 436717005146 Q-loop/lid; other site 436717005147 ABC transporter signature motif; other site 436717005148 Walker B; other site 436717005149 D-loop; other site 436717005150 H-loop/switch region; other site 436717005151 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 436717005152 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 436717005153 dimer interface [polypeptide binding]; other site 436717005154 conserved gate region; other site 436717005155 putative PBP binding loops; other site 436717005156 ABC-ATPase subunit interface; other site 436717005157 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 436717005158 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 436717005159 alkanesulfonate monooxygenase, FMNH(2)-dependent; Region: alk_sulf_monoox; TIGR03565 436717005160 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 436717005161 active site 436717005162 dimer interface [polypeptide binding]; other site 436717005163 non-prolyl cis peptide bond; other site 436717005164 insertion regions; other site 436717005165 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 436717005166 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 436717005167 N-terminal plug; other site 436717005168 ligand-binding site [chemical binding]; other site 436717005169 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 436717005170 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 436717005171 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_17; cd08503 436717005172 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 436717005173 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 436717005174 TolR protein; Region: tolR; TIGR02801 436717005175 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 436717005176 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 436717005177 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 436717005178 alkanesulfonate monooxygenase, FMNH(2)-dependent; Region: alk_sulf_monoox; TIGR03565 436717005179 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 436717005180 active site 436717005181 dimer interface [polypeptide binding]; other site 436717005182 non-prolyl cis peptide bond; other site 436717005183 insertion regions; other site 436717005184 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 436717005185 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 436717005186 membrane-bound complex binding site; other site 436717005187 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 436717005188 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 436717005189 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 436717005190 dimer interface [polypeptide binding]; other site 436717005191 conserved gate region; other site 436717005192 ABC-ATPase subunit interface; other site 436717005193 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 436717005194 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 436717005195 Walker A/P-loop; other site 436717005196 ATP binding site [chemical binding]; other site 436717005197 Q-loop/lid; other site 436717005198 ABC transporter signature motif; other site 436717005199 Walker B; other site 436717005200 D-loop; other site 436717005201 H-loop/switch region; other site 436717005202 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 436717005203 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 436717005204 Sec-independent protein translocase protein (TatC); Region: TatC; cl00521 436717005205 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 436717005206 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 436717005207 Walker A motif; other site 436717005208 ATP binding site [chemical binding]; other site 436717005209 Walker B motif; other site 436717005210 arginine finger; other site 436717005211 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 436717005212 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 436717005213 dimer interface [polypeptide binding]; other site 436717005214 active site 436717005215 non-prolyl cis peptide bond; other site 436717005216 insertion regions; other site 436717005217 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 436717005218 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 436717005219 N-terminal plug; other site 436717005220 ligand-binding site [chemical binding]; other site 436717005221 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 436717005222 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 436717005223 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 436717005224 Walker A/P-loop; other site 436717005225 ATP binding site [chemical binding]; other site 436717005226 Q-loop/lid; other site 436717005227 ABC transporter signature motif; other site 436717005228 Walker B; other site 436717005229 D-loop; other site 436717005230 H-loop/switch region; other site 436717005231 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 436717005232 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 436717005233 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 436717005234 Walker A/P-loop; other site 436717005235 ATP binding site [chemical binding]; other site 436717005236 Q-loop/lid; other site 436717005237 ABC transporter signature motif; other site 436717005238 Walker B; other site 436717005239 D-loop; other site 436717005240 H-loop/switch region; other site 436717005241 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 436717005242 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 436717005243 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 436717005244 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 436717005245 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 436717005246 active site 436717005247 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 436717005248 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 436717005249 Walker A/P-loop; other site 436717005250 ATP binding site [chemical binding]; other site 436717005251 Q-loop/lid; other site 436717005252 ABC transporter signature motif; other site 436717005253 Walker B; other site 436717005254 D-loop; other site 436717005255 H-loop/switch region; other site 436717005256 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 436717005257 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 436717005258 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 436717005259 Walker A/P-loop; other site 436717005260 ATP binding site [chemical binding]; other site 436717005261 Q-loop/lid; other site 436717005262 ABC transporter signature motif; other site 436717005263 Walker B; other site 436717005264 D-loop; other site 436717005265 H-loop/switch region; other site 436717005266 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 436717005267 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 436717005268 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 436717005269 dimer interface [polypeptide binding]; other site 436717005270 conserved gate region; other site 436717005271 putative PBP binding loops; other site 436717005272 ABC-ATPase subunit interface; other site 436717005273 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 436717005274 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 436717005275 dimer interface [polypeptide binding]; other site 436717005276 conserved gate region; other site 436717005277 putative PBP binding loops; other site 436717005278 ABC-ATPase subunit interface; other site 436717005279 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_17; cd08503 436717005280 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 436717005281 alkanesulfonate monooxygenase; Provisional; Region: PRK00719 436717005282 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 436717005283 active site 436717005284 dimer interface [polypeptide binding]; other site 436717005285 non-prolyl cis peptide bond; other site 436717005286 insertion regions; other site 436717005287 active site 436717005288 Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; smart01007 436717005289 Zn2+ binding site [ion binding]; other site 436717005290 intersubunit interface [polypeptide binding]; other site 436717005291 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 436717005292 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 436717005293 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 436717005294 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 436717005295 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 436717005296 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 436717005297 PapC N-terminal domain; Region: PapC_N; pfam13954 436717005298 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 436717005299 PapC C-terminal domain; Region: PapC_C; pfam13953 436717005300 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 436717005301 class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300 436717005302 S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase; Region: adh_III_F_hyde; TIGR02818 436717005303 substrate binding site [chemical binding]; other site 436717005304 catalytic Zn binding site [ion binding]; other site 436717005305 NAD binding site [chemical binding]; other site 436717005306 structural Zn binding site [ion binding]; other site 436717005307 dimer interface [polypeptide binding]; other site 436717005308 Catalase-like heme-binding proteins similar to the uncharacterized y4iL; Region: y4iL_like; cd08152 436717005309 putative heme binding pocket [chemical binding]; other site 436717005310 Uncharacterized conserved protein [Function unknown]; Region: COG3791 436717005311 Putative catalytic domain, repeat 1, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_1; cd09111 436717005312 PLD-like domain; Region: PLDc_2; pfam13091 436717005313 putative active site [active] 436717005314 catalytic site [active] 436717005315 Putative catalytic domain, repeat 2, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_2; cd09113 436717005316 PLD-like domain; Region: PLDc_2; pfam13091 436717005317 putative active site [active] 436717005318 catalytic site [active] 436717005319 MUG-like Uracil-DNA glycosylase enzyme family; Region: UDG_MUG_like; cd10032 436717005320 putative active site [active] 436717005321 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 436717005322 renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301 436717005323 active site 436717005324 dimer interface [polypeptide binding]; other site 436717005325 pyrroloquinoline quinone biosynthesis protein PqqE; Provisional; Region: PRK05301 436717005326 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 436717005327 FeS/SAM binding site; other site 436717005328 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 436717005329 pyrroloquinoline quinone biosynthesis protein PqqD; Provisional; Region: PRK02079 436717005330 pyrroloquinoline quinone biosynthesis protein PqqC; Provisional; Region: PRK05157 436717005331 pyrroloquinoline quinone biosynthesis protein PqqB; Provisional; Region: PRK05184 436717005332 coenzyme PQQ biosynthesis protein B; Region: PQQ_syn_pqqB; TIGR02108 436717005333 coenzyme PQQ synthesis protein PqqA; Provisional; Region: pqqA; PRK00284 436717005334 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 436717005335 Bacillus subtilis YhcR endonuclease and related proteins, N-terminal metallophosphatase domain; Region: MPP_YhcR_N; cd07412 436717005336 putative active site [active] 436717005337 putative metal binding site [ion binding]; other site 436717005338 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 436717005339 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cl17326 436717005340 metal binding site 2 [ion binding]; metal-binding site 436717005341 putative DNA binding helix; other site 436717005342 metal binding site 1 [ion binding]; metal-binding site 436717005343 dimer interface [polypeptide binding]; other site 436717005344 structural Zn2+ binding site [ion binding]; other site 436717005345 Outer membrane receptor for ferrienterochelin and colicins [Inorganic ion transport and metabolism]; Region: FepA; COG4771 436717005346 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 436717005347 N-terminal plug; other site 436717005348 ligand-binding site [chemical binding]; other site 436717005349 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 436717005350 Protein export membrane protein; Region: SecD_SecF; cl14618 436717005351 Isochorismatase, also known as 2,3 dihydro-2,3 dihydroxybenzoate synthase, catalyses the conversion of isochorismate, in the presence of water, to 2,3-dihydroxybenzoate and pyruvate, via the hydrolysis of a vinyl ether, an uncommon reaction in biological...; Region: isochorismatase; cd01013 436717005352 hydrophobic substrate binding pocket; other site 436717005353 Isochorismatase family; Region: Isochorismatase; pfam00857 436717005354 active site 436717005355 conserved cis-peptide bond; other site 436717005356 Aryl carrier domain [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3433 436717005357 Peptide arylation enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntE; COG1021 436717005358 2,3-dihydroxybenzoate-AMP ligase; Region: 23DHB-AMP_lg; cd05920 436717005359 acyl-activating enzyme (AAE) consensus motif; other site 436717005360 active site 436717005361 AMP binding site [chemical binding]; other site 436717005362 substrate binding site [chemical binding]; other site 436717005363 isochorismate synthase DhbC; Validated; Region: PRK06923 436717005364 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 436717005365 2,3-dihydroxybenzoate-2,3-dehydrogenase; Validated; Region: PRK08220 436717005366 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 436717005367 NAD(P) binding site [chemical binding]; other site 436717005368 active site 436717005369 enterobactin/ferric enterobactin esterase; Provisional; Region: PRK10439 436717005370 Domain of unknown function (DUF3327); Region: DUF3327; pfam11806 436717005371 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 436717005372 MbtH-like protein; Region: MbtH; cl01279 436717005373 Condensation domain; Region: Condensation; pfam00668 436717005374 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 436717005375 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 436717005376 acyl-activating enzyme (AAE) consensus motif; other site 436717005377 AMP binding site [chemical binding]; other site 436717005378 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 436717005379 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 436717005380 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 436717005381 acyl-activating enzyme (AAE) consensus motif; other site 436717005382 AMP binding site [chemical binding]; other site 436717005383 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 436717005384 enterobactin exporter EntS; Provisional; Region: PRK10489 436717005385 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 436717005386 putative substrate translocation pore; other site 436717005387 Phosphopantetheinyl transferase component of siderophore synthetase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntD; COG2977 436717005388 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 436717005389 PepSY-associated TM helix; Region: PepSY_TM_3; pfam13706 436717005390 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 436717005391 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 436717005392 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 436717005393 Walker A/P-loop; other site 436717005394 ATP binding site [chemical binding]; other site 436717005395 Q-loop/lid; other site 436717005396 ABC transporter signature motif; other site 436717005397 Walker B; other site 436717005398 D-loop; other site 436717005399 H-loop/switch region; other site 436717005400 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 436717005401 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 436717005402 dimer interface [polypeptide binding]; other site 436717005403 conserved gate region; other site 436717005404 putative PBP binding loops; other site 436717005405 ABC-ATPase subunit interface; other site 436717005406 molybdate transporter periplasmic protein; Provisional; Region: modA; PRK10677 436717005407 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 436717005408 N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; cl17549 436717005409 anthranilate 1,2-dioxygenase, large subunit; Region: anthran_1_2_A; TIGR03228 436717005410 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 436717005411 [2Fe-2S] cluster binding site [ion binding]; other site 436717005412 C-terminal catalytic domain of the oxygenase alpha subunit of Pseudomonas resinovorans strain CA10 anthranilate 1,2-dioxygenase and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_AntDO-like; cd08879 436717005413 putative alpha subunit interface [polypeptide binding]; other site 436717005414 putative active site [active] 436717005415 putative substrate binding site [chemical binding]; other site 436717005416 Fe binding site [ion binding]; other site 436717005417 Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667 436717005418 inter-subunit interface; other site 436717005419 anthranilate dioxygenase reductase; Provisional; Region: antC; PRK11872 436717005420 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 436717005421 catalytic loop [active] 436717005422 iron binding site [ion binding]; other site 436717005423 Benzoate dioxygenase reductase (BenDO) FAD/NAD binding domain. Oxygenases oxidize hydrocarbons using dioxygen as the oxidant. As a Class I bacterial dioxygenases, benzoate dioxygenase like proteins combine an [2Fe-2S] cluster containing N-terminal...; Region: BenDO_FAD_NAD; cd06209 436717005424 FAD binding pocket [chemical binding]; other site 436717005425 FAD binding motif [chemical binding]; other site 436717005426 phosphate binding motif [ion binding]; other site 436717005427 beta-alpha-beta structure motif; other site 436717005428 NAD binding pocket [chemical binding]; other site 436717005429 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 436717005430 Helix-turn-helix domain; Region: HTH_18; pfam12833 436717005431 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 436717005432 Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; cl01768 436717005433 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 436717005434 short chain dehydrogenase; Provisional; Region: PRK08265 436717005435 classical (c) SDRs; Region: SDR_c; cd05233 436717005436 NAD(P) binding site [chemical binding]; other site 436717005437 active site 436717005438 Dienelactone hydrolase family; Region: DLH; pfam01738 436717005439 SnoaL-like domain; Region: SnoaL_2; pfam12680 436717005440 outer membrane porin, OprD family; Region: OprD; pfam03573 436717005441 benzoate transport; Region: 2A0115; TIGR00895 436717005442 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 436717005443 putative substrate translocation pore; other site 436717005444 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 436717005445 Helix-turn-helix domain; Region: HTH_18; pfam12833 436717005446 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 436717005447 3-hydroxybutyrate dehydrogenase; Provisional; Region: PRK12429 436717005448 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 436717005449 NAD(P) binding site [chemical binding]; other site 436717005450 active site 436717005451 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 436717005452 fructuronate transporter; Provisional; Region: PRK10034; cl15264 436717005453 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 436717005454 Sensors of blue-light using FAD; Region: BLUF; pfam04940 436717005455 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 436717005456 active site 436717005457 Helix-turn-helix domain; Region: HTH_18; pfam12833 436717005458 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 436717005459 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 436717005460 Major Facilitator Superfamily; Region: MFS_1; pfam07690 436717005461 putative substrate translocation pore; other site 436717005462 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 436717005463 Protein of unknown function (DUF2846); Region: DUF2846; pfam11008 436717005464 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 436717005465 Transcriptional regulator [Transcription]; Region: LysR; COG0583 436717005466 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 436717005467 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 436717005468 putative dimerization interface [polypeptide binding]; other site 436717005469 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 436717005470 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 436717005471 Short chain fatty acids transporter [Lipid metabolism]; Region: AtoE; COG2031 436717005472 acetyl-CoA acetyltransferase; Provisional; Region: PRK06954 436717005473 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 436717005474 dimer interface [polypeptide binding]; other site 436717005475 active site 436717005476 Transcriptional regulator [Transcription]; Region: LysR; COG0583 436717005477 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 436717005478 The C-terminal substrate binding domain of LysR-type transcriptional regulators that are involved in the catabolism of dinitrotoluene, naphthalene and gamma-hexachlorohexane; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_NahR_LinR_like; cd08459 436717005479 substrate binding pocket [chemical binding]; other site 436717005480 dimerization interface [polypeptide binding]; other site 436717005481 cell density-dependent motility repressor; Provisional; Region: PRK10082 436717005482 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 436717005483 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 436717005484 dimerization interface [polypeptide binding]; other site 436717005485 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 436717005486 Aspartase; Region: Aspartase; cd01357 436717005487 active sites [active] 436717005488 tetramer interface [polypeptide binding]; other site 436717005489 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 436717005490 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 436717005491 N-terminal plug; other site 436717005492 ligand-binding site [chemical binding]; other site 436717005493 alpha-ketoglutarate transporter; Provisional; Region: PRK10406 436717005494 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 436717005495 putative substrate translocation pore; other site 436717005496 Protein of unknown function (DUF971); Region: DUF971; pfam06155 436717005497 FOG: HEAT repeat [Energy production and conversion]; Region: COG1413 436717005498 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 436717005499 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 436717005500 Walker A/P-loop; other site 436717005501 ATP binding site [chemical binding]; other site 436717005502 Q-loop/lid; other site 436717005503 ABC transporter signature motif; other site 436717005504 Walker B; other site 436717005505 D-loop; other site 436717005506 H-loop/switch region; other site 436717005507 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 436717005508 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 436717005509 dimer interface [polypeptide binding]; other site 436717005510 conserved gate region; other site 436717005511 putative PBP binding loops; other site 436717005512 ABC-ATPase subunit interface; other site 436717005513 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 436717005514 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 436717005515 substrate binding pocket [chemical binding]; other site 436717005516 membrane-bound complex binding site; other site 436717005517 Ferredoxin [Energy production and conversion]; Region: COG1146 436717005518 putative oxidoreductase; Provisional; Region: PRK08275 436717005519 L-aspartate oxidase; Provisional; Region: PRK06175 436717005520 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 436717005521 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 436717005522 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 436717005523 DNA-binding site [nucleotide binding]; DNA binding site 436717005524 UTRA domain; Region: UTRA; pfam07702 436717005525 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 436717005526 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 436717005527 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 436717005528 EamA-like transporter family; Region: EamA; pfam00892 436717005529 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 436717005530 EamA-like transporter family; Region: EamA; pfam00892 436717005531 homoserine dehydrogenase; Provisional; Region: PRK06270 436717005532 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 436717005533 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 436717005534 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 436717005535 Putative phosphatase (DUF442); Region: DUF442; cl17385 436717005536 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 436717005537 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 436717005538 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 436717005539 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 436717005540 Walker A motif; other site 436717005541 ATP binding site [chemical binding]; other site 436717005542 Walker B motif; other site 436717005543 arginine finger; other site 436717005544 Bestrophin, RFP-TM, chloride channel; Region: Bestrophin; pfam01062 436717005545 (2R,3R)-2,3-butanediol dehydrogenase; Region: butanediol_DH_like; cd08233 436717005546 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 436717005547 putative NAD(P) binding site [chemical binding]; other site 436717005548 catalytic Zn binding site [ion binding]; other site 436717005549 acetoin reductases; Region: 23BDH; TIGR02415 436717005550 meso-2,3-butanediol dehydrogenase-like, classical (c) SDRs; Region: meso-BDH-like_SDR_c; cd05366 436717005551 NAD binding site [chemical binding]; other site 436717005552 homotetramer interface [polypeptide binding]; other site 436717005553 homodimer interface [polypeptide binding]; other site 436717005554 active site 436717005555 substrate binding site [chemical binding]; other site 436717005556 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 436717005557 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 436717005558 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 436717005559 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 436717005560 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 436717005561 E3 interaction surface; other site 436717005562 lipoyl attachment site [posttranslational modification]; other site 436717005563 dihydrolipoamide acetyltransferase; Provisional; Region: PRK14843 436717005564 e3 binding domain; Region: E3_binding; pfam02817 436717005565 e3 binding domain; Region: E3_binding; pfam02817 436717005566 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 436717005567 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 436717005568 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 436717005569 alpha subunit interface [polypeptide binding]; other site 436717005570 TPP binding site [chemical binding]; other site 436717005571 heterodimer interface [polypeptide binding]; other site 436717005572 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 436717005573 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182 436717005574 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 436717005575 tetramer interface [polypeptide binding]; other site 436717005576 TPP-binding site [chemical binding]; other site 436717005577 heterodimer interface [polypeptide binding]; other site 436717005578 phosphorylation loop region [posttranslational modification] 436717005579 lipoyl synthase; Provisional; Region: PRK12928 436717005580 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 436717005581 FeS/SAM binding site; other site 436717005582 DNA-binding transcriptional regulator DhaR; Provisional; Region: PRK11388 436717005583 TENA/THI-4/PQQC family; Region: TENA_THI-4; cl15243 436717005584 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 436717005585 metal binding site [ion binding]; metal-binding site 436717005586 active site 436717005587 I-site; other site 436717005588 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 436717005589 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 436717005590 Tetramer interface [polypeptide binding]; other site 436717005591 active site 436717005592 FMN-binding site [chemical binding]; other site 436717005593 HemK family putative methylases; Region: hemK_fam; TIGR00536 436717005594 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 436717005595 S-adenosylmethionine binding site [chemical binding]; other site 436717005596 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 436717005597 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 436717005598 pyridoxal 5'-phosphate binding site [chemical binding]; other site 436717005599 catalytic residue [active] 436717005600 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3825 436717005601 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 436717005602 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 436717005603 Walker A motif; other site 436717005604 ATP binding site [chemical binding]; other site 436717005605 Walker B motif; other site 436717005606 arginine finger; other site 436717005607 YcgL domain; Region: YcgL; cl01189 436717005608 Transcriptional regulator [Transcription]; Region: LysR; COG0583 436717005609 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 436717005610 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 436717005611 dimerization interface [polypeptide binding]; other site 436717005612 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 436717005613 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 436717005614 ribonuclease D; Region: rnd; TIGR01388 436717005615 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 436717005616 catalytic site [active] 436717005617 putative active site [active] 436717005618 putative substrate binding site [chemical binding]; other site 436717005619 HRDC domain; Region: HRDC; pfam00570 436717005620 recombination protein RecR; Reviewed; Region: recR; PRK00076 436717005621 RecR protein; Region: RecR; pfam02132 436717005622 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 436717005623 putative active site [active] 436717005624 putative metal-binding site [ion binding]; other site 436717005625 tetramer interface [polypeptide binding]; other site 436717005626 hypothetical protein; Validated; Region: PRK00153 436717005627 O-succinylhomoserine sulfhydrylase; Validated; Region: PRK08133 436717005628 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 436717005629 homodimer interface [polypeptide binding]; other site 436717005630 substrate-cofactor binding pocket; other site 436717005631 pyridoxal 5'-phosphate binding site [chemical binding]; other site 436717005632 catalytic residue [active] 436717005633 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 436717005634 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 436717005635 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 436717005636 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 436717005637 HIT family signature motif; other site 436717005638 catalytic residue [active] 436717005639 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 436717005640 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 436717005641 eyelet of channel; other site 436717005642 trimer interface [polypeptide binding]; other site 436717005643 Bacterial protein of unknown function (DUF937); Region: DUF937; cl01528 436717005644 Protein of unknown function (DUF2797); Region: DUF2797; pfam10977 436717005645 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 436717005646 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 436717005647 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 436717005648 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 436717005649 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 436717005650 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 436717005651 Walker A/P-loop; other site 436717005652 ATP binding site [chemical binding]; other site 436717005653 Q-loop/lid; other site 436717005654 ABC transporter signature motif; other site 436717005655 Walker B; other site 436717005656 D-loop; other site 436717005657 H-loop/switch region; other site 436717005658 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 436717005659 ATP-binding cassette domain of the lipid transporters, subfamily A; Region: ABC_subfamily_A; cd03263 436717005660 Walker A/P-loop; other site 436717005661 ATP binding site [chemical binding]; other site 436717005662 Q-loop/lid; other site 436717005663 ABC transporter signature motif; other site 436717005664 Walker B; other site 436717005665 D-loop; other site 436717005666 H-loop/switch region; other site 436717005667 putative efflux pump membrane fusion protein; Provisional; Region: PRK03598 436717005668 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 436717005669 HlyD family secretion protein; Region: HlyD_3; pfam13437 436717005670 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 436717005671 Domain of unknown function (DUF1956); Region: DUF1956; pfam09209 436717005672 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 436717005673 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 436717005674 Outer membrane receptor for ferric coprogen and ferric-rhodotorulic acid [Inorganic ion transport and metabolism]; Region: FhuE; COG4773 436717005675 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 436717005676 N-terminal plug; other site 436717005677 ligand-binding site [chemical binding]; other site 436717005678 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 436717005679 PepSY-associated TM helix; Region: PepSY_TM_3; pfam13706 436717005680 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 436717005681 Undecaprenyl-phosphate glucose phosphotransferase; Region: WcaJ_sugtrans; TIGR03023 436717005682 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 436717005683 phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261 436717005684 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 436717005685 cobalamin synthase; Reviewed; Region: cobS; PRK00235 436717005686 Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061 436717005687 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 436717005688 catalytic core [active] 436717005689 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 436717005690 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 436717005691 putative dimer interface [polypeptide binding]; other site 436717005692 active site pocket [active] 436717005693 putative cataytic base [active] 436717005694 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 436717005695 homotrimer interface [polypeptide binding]; other site 436717005696 Walker A motif; other site 436717005697 GTP binding site [chemical binding]; other site 436717005698 Walker B motif; other site 436717005699 2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563 436717005700 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 436717005701 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 436717005702 motif II; other site 436717005703 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 436717005704 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 436717005705 putative deacylase active site [active] 436717005706 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 436717005707 ABC1 family; Region: ABC1; cl17513 436717005708 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 436717005709 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 436717005710 active site 436717005711 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 436717005712 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 436717005713 active site 436717005714 Alkane hydroxylase is a bacterial, integral-membrane di-iron enzyme that shares a requirement for iron and oxygen for activity similar to that of the non-heme integral-membrane acyl coenzyme A (CoA) desaturases and acyl lipid desaturases. The alk genes...; Region: Alkane-hydroxylase; cd03512 436717005715 Fatty acid desaturase; Region: FA_desaturase; pfam00487 436717005716 Di-iron ligands [ion binding]; other site 436717005717 Cupin; Region: Cupin_6; pfam12852 436717005718 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 436717005719 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 436717005720 periplasmic folding chaperone; Provisional; Region: PRK10788 436717005721 SurA N-terminal domain; Region: SurA_N_3; cl07813 436717005722 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 436717005723 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 436717005724 IHF dimer interface [polypeptide binding]; other site 436717005725 IHF - DNA interface [nucleotide binding]; other site 436717005726 Poly(hydroxyalcanoate) granule associated protein (phasin); Region: Phasin; pfam05597 436717005727 Transcriptional regulator; Region: Rrf2; cl17282 436717005728 Rrf2 family protein; Region: rrf2_super; TIGR00738 436717005729 cysteine desulfurase; Provisional; Region: PRK14012 436717005730 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 436717005731 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 436717005732 catalytic residue [active] 436717005733 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 436717005734 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 436717005735 trimerization site [polypeptide binding]; other site 436717005736 active site 436717005737 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 436717005738 co-chaperone HscB; Provisional; Region: hscB; PRK05014 436717005739 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 436717005740 HSP70 interaction site [polypeptide binding]; other site 436717005741 HSCB C-terminal oligomerisation domain; Region: HSCB_C; pfam07743 436717005742 chaperone protein HscA; Provisional; Region: hscA; PRK05183 436717005743 Nucleotide-binding domain of HscA and similar proteins; Region: HscA_like_NBD; cd10236 436717005744 nucleotide binding site [chemical binding]; other site 436717005745 putative NEF/HSP70 interaction site [polypeptide binding]; other site 436717005746 SBD interface [polypeptide binding]; other site 436717005747 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 436717005748 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 436717005749 catalytic loop [active] 436717005750 iron binding site [ion binding]; other site 436717005751 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 436717005752 cyclase homology domain; Region: CHD; cd07302 436717005753 nucleotidyl binding site; other site 436717005754 metal binding site [ion binding]; metal-binding site 436717005755 dimer interface [polypeptide binding]; other site 436717005756 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 436717005757 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 436717005758 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 436717005759 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 436717005760 ATP binding site [chemical binding]; other site 436717005761 putative Mg++ binding site [ion binding]; other site 436717005762 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 436717005763 nucleotide binding region [chemical binding]; other site 436717005764 ATP-binding site [chemical binding]; other site 436717005765 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 436717005766 Dyp-type peroxidase family; Region: Dyp_perox; cl01067 436717005767 GST_N family, 2 repeats of the N-terminal domain of soluble GSTs (2 GST_N) subfamily; composed of uncharacterized proteins. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a...; Region: GST_N_2GST_N; cd03041 436717005768 putative C-terminal domain interface [polypeptide binding]; other site 436717005769 putative GSH binding site (G-site) [chemical binding]; other site 436717005770 putative dimer interface [polypeptide binding]; other site 436717005771 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 436717005772 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 436717005773 ribonuclease activity regulator protein RraA; Provisional; Region: PRK09372 436717005774 CC3(TIP30)-like, atypical (a) SDRs; Region: CC3_like_SDR_a; cd05250 436717005775 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 436717005776 NAD binding site [chemical binding]; other site 436717005777 active site 436717005778 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 436717005779 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 436717005780 catalytic core [active] 436717005781 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 436717005782 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 436717005783 active site 436717005784 Uncharacterized ACR, COG2135; Region: DUF159; pfam02586 436717005785 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 436717005786 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 436717005787 Walker A/P-loop; other site 436717005788 ATP binding site [chemical binding]; other site 436717005789 Q-loop/lid; other site 436717005790 ABC transporter signature motif; other site 436717005791 Walker B; other site 436717005792 D-loop; other site 436717005793 H-loop/switch region; other site 436717005794 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 436717005795 Walker A/P-loop; other site 436717005796 ATP binding site [chemical binding]; other site 436717005797 Q-loop/lid; other site 436717005798 ABC transporter signature motif; other site 436717005799 Walker B; other site 436717005800 D-loop; other site 436717005801 H-loop/switch region; other site 436717005802 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 436717005803 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 436717005804 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 436717005805 dimer interface [polypeptide binding]; other site 436717005806 conserved gate region; other site 436717005807 putative PBP binding loops; other site 436717005808 ABC-ATPase subunit interface; other site 436717005809 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 436717005810 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 436717005811 dimer interface [polypeptide binding]; other site 436717005812 conserved gate region; other site 436717005813 putative PBP binding loops; other site 436717005814 ABC-ATPase subunit interface; other site 436717005815 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 436717005816 Peptidase M3 Thimet oligopeptidase (TOP) also includes neurolysin; Region: M3A_TOP; cd06455 436717005817 active site 436717005818 Zn binding site [ion binding]; other site 436717005819 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_18; cd08505 436717005820 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 436717005821 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_18; cd08505 436717005822 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 436717005823 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 436717005824 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 436717005825 N-terminal plug; other site 436717005826 ligand-binding site [chemical binding]; other site 436717005827 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 436717005828 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 436717005829 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 436717005830 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 436717005831 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 436717005832 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 436717005833 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 436717005834 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 436717005835 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 436717005836 Coenzyme A binding pocket [chemical binding]; other site 436717005837 malate synthase G; Provisional; Region: PRK02999 436717005838 active site 436717005839 Predicted ATPase [General function prediction only]; Region: COG1485 436717005840 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 436717005841 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 436717005842 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 436717005843 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 436717005844 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 436717005845 Membrane protein of unknown function (DUF340); Region: DUF340; cl01028 436717005846 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 436717005847 active site 436717005848 dimer interface [polypeptide binding]; other site 436717005849 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 436717005850 IHF dimer interface [polypeptide binding]; other site 436717005851 IHF - DNA interface [nucleotide binding]; other site 436717005852 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 436717005853 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 436717005854 RNA binding site [nucleotide binding]; other site 436717005855 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 436717005856 RNA binding site [nucleotide binding]; other site 436717005857 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 436717005858 RNA binding site [nucleotide binding]; other site 436717005859 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 436717005860 RNA binding site [nucleotide binding]; other site 436717005861 S1_RPS1_repeat_ec5: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec5; cd05690 436717005862 RNA binding site [nucleotide binding]; other site 436717005863 S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec6; cd05691 436717005864 RNA binding site [nucleotide binding]; other site 436717005865 cytidylate kinase; Provisional; Region: cmk; PRK00023 436717005866 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 436717005867 CMP-binding site; other site 436717005868 The sites determining sugar specificity; other site 436717005869 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 436717005870 putative hydrophobic ligand binding site [chemical binding]; other site 436717005871 protein interface [polypeptide binding]; other site 436717005872 gate; other site 436717005873 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 436717005874 nucleoside/Zn binding site; other site 436717005875 dimer interface [polypeptide binding]; other site 436717005876 catalytic motif [active] 436717005877 3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617 436717005878 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 436717005879 substrate binding site [chemical binding]; other site 436717005880 oxyanion hole (OAH) forming residues; other site 436717005881 trimer interface [polypeptide binding]; other site 436717005882 2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766 436717005883 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 436717005884 ligand binding site [chemical binding]; other site 436717005885 active site 436717005886 UGI interface [polypeptide binding]; other site 436717005887 catalytic site [active] 436717005888 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 436717005889 Type II secretion system (T2SS), protein K; Region: T2SK; pfam03934 436717005890 type II secretion system protein J; Region: gspJ; TIGR01711 436717005891 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 436717005892 Type II secretion system (T2SS), protein J; Region: T2SJ; pfam11612 436717005893 Type II secretion system (T2SS), protein I; Region: T2SI; pfam02501 436717005894 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 436717005895 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 436717005896 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 436717005897 active site 436717005898 PilZ domain; Region: PilZ; cl01260 436717005899 DNA polymerase III subunit delta'; Validated; Region: PRK05707 436717005900 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 436717005901 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 436717005902 Ligand binding site; other site 436717005903 oligomer interface; other site 436717005904 tetraacyldisaccharide 4'-kinase; Reviewed; Region: lpxK; PRK00652 436717005905 Tetraacyldisaccharide-1-P 4'-kinase [Cell envelope biogenesis, outer membrane]; Region: LpxK; COG1663 436717005906 lipid A export permease/ATP-binding protein MsbA; Region: MsbA_lipidA; TIGR02203 436717005907 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 436717005908 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 436717005909 Walker A/P-loop; other site 436717005910 ATP binding site [chemical binding]; other site 436717005911 Q-loop/lid; other site 436717005912 ABC transporter signature motif; other site 436717005913 Walker B; other site 436717005914 D-loop; other site 436717005915 H-loop/switch region; other site 436717005916 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 436717005917 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 436717005918 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 436717005919 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 436717005920 ParB-like nuclease domain; Region: ParB; smart00470 436717005921 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 436717005922 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 436717005923 P-loop; other site 436717005924 Magnesium ion binding site [ion binding]; other site 436717005925 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 436717005926 Magnesium ion binding site [ion binding]; other site 436717005927 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 436717005928 rRNA small subunit methyltransferase G; Region: GidB; pfam02527 436717005929 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 436717005930 NTP_transferase_like_1 is a member of the nucleotidyl transferase family; Region: NTP_transferase_like_1; cd06422 436717005931 Substrate binding site; other site 436717005932 metal-binding site 436717005933 Predicted phosphotransferase related to Ser/Thr protein kinases [General function prediction only]; Region: COG3178 436717005934 Phosphotransferase enzyme family; Region: APH; pfam01636 436717005935 Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452 436717005936 Organic solvent tolerance protein; Region: OstA_C; pfam04453 436717005937 peptidyl-prolyl cis-trans isomerase SurA; Provisional; Region: PRK10770 436717005938 SurA N-terminal domain; Region: SurA_N; pfam09312 436717005939 PPIC-type PPIASE domain; Region: Rotamase_2; cl08278 436717005940 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 436717005941 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 436717005942 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 436717005943 intersubunit interface [polypeptide binding]; other site 436717005944 active site 436717005945 zinc binding site [ion binding]; other site 436717005946 Na+ binding site [ion binding]; other site 436717005947 phosphoglycerate kinase; Provisional; Region: pgk; PRK00073 436717005948 Phosphoglycerate kinase; Region: PGK; pfam00162 436717005949 substrate binding site [chemical binding]; other site 436717005950 hinge regions; other site 436717005951 ADP binding site [chemical binding]; other site 436717005952 catalytic site [active] 436717005953 Uncharacterized protein conserved in bacteria (DUF2237); Region: DUF2237; pfam09996 436717005954 Maf-like protein; Region: Maf; pfam02545 436717005955 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 436717005956 active site 436717005957 dimer interface [polypeptide binding]; other site 436717005958 Cupin superfamily protein; Region: Cupin_4; pfam08007 436717005959 A domain family that is part of the cupin metalloenzyme superfamily; Region: JmjC; smart00558 436717005960 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 436717005961 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 436717005962 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 436717005963 dimerization interface [polypeptide binding]; other site 436717005964 putative DNA binding site [nucleotide binding]; other site 436717005965 putative Zn2+ binding site [ion binding]; other site 436717005966 serine/threonine transporter SstT; Provisional; Region: PRK13628 436717005967 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 436717005968 Protein of unknown function (DUF1275); Region: DUF1275; pfam06912 436717005969 Uncharacterized protein conserved in bacteria (DUF2058); Region: DUF2058; pfam09831 436717005970 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 436717005971 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 436717005972 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 436717005973 Walker A/P-loop; other site 436717005974 ATP binding site [chemical binding]; other site 436717005975 Q-loop/lid; other site 436717005976 ABC transporter signature motif; other site 436717005977 Walker B; other site 436717005978 D-loop; other site 436717005979 H-loop/switch region; other site 436717005980 YdeM is a Bacillus subtilis protein that belongs to a family of prokaryotic proteins of unkown function. YdeM has sequence similarity to the hot-dog fold of (R)-specific enoyl-CoA hydratase. Other enzymes with this fold include the peroxisomal...; Region: YdeM; cd03454 436717005981 putative active site [active] 436717005982 putative catalytic site [active] 436717005983 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 436717005984 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 436717005985 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 436717005986 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 436717005987 lipoyl attachment site [posttranslational modification]; other site 436717005988 NAD-dependent deacetylase; Provisional; Region: PRK00481 436717005989 SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412 436717005990 NAD+ binding site [chemical binding]; other site 436717005991 substrate binding site [chemical binding]; other site 436717005992 Zn binding site [ion binding]; other site 436717005993 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 436717005994 Na binding site [ion binding]; other site 436717005995 leucine-responsive transcriptional regulator; Provisional; Region: PRK11169 436717005996 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 436717005997 dimerization interface [polypeptide binding]; other site 436717005998 putative DNA binding site [nucleotide binding]; other site 436717005999 putative Zn2+ binding site [ion binding]; other site 436717006000 AsnC family; Region: AsnC_trans_reg; pfam01037 436717006001 bifunctional proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: PRK11905 436717006002 Proline dehydrogenase [Amino acid transport and metabolism]; Region: PutA; COG0506 436717006003 Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125 436717006004 Glutamate binding site [chemical binding]; other site 436717006005 NAD binding site [chemical binding]; other site 436717006006 catalytic residues [active] 436717006007 Uncharacterized protein family (UPF0157); Region: UPF0157; cl00987 436717006008 tRNA (uracil-5-)-methyltransferase; Validated; Region: PRK05031 436717006009 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 436717006010 S-adenosylmethionine binding site [chemical binding]; other site 436717006011 Predicted periplasmic protein [Function unknown]; Region: COG3698 436717006012 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 436717006013 Lecithin retinol acyltransferase; Region: LRAT; pfam04970 436717006014 Uncharacterized conserved protein [Function unknown]; Region: COG2353 436717006015 OsmC-like protein; Region: OsmC; pfam02566 436717006016 transketolase; Reviewed; Region: PRK12753 436717006017 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 436717006018 TPP-binding site [chemical binding]; other site 436717006019 dimer interface [polypeptide binding]; other site 436717006020 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 436717006021 PYR/PP interface [polypeptide binding]; other site 436717006022 dimer interface [polypeptide binding]; other site 436717006023 TPP binding site [chemical binding]; other site 436717006024 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 436717006025 S-adenosylmethionine synthetase; Validated; Region: PRK05250 436717006026 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 436717006027 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 436717006028 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 436717006029 N2,N2-dimethylguanosine tRNA methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TRM1; COG1867 436717006030 FxsA cytoplasmic membrane protein; Region: FxsA; pfam04186 436717006031 Beta-lactamase class D [Defense mechanisms]; Region: COG2602 436717006032 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 436717006033 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 436717006034 Coenzyme A binding pocket [chemical binding]; other site 436717006035 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 436717006036 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 436717006037 non-specific DNA binding site [nucleotide binding]; other site 436717006038 salt bridge; other site 436717006039 sequence-specific DNA binding site [nucleotide binding]; other site 436717006040 Cupin domain; Region: Cupin_2; cl17218 436717006041 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 436717006042 active site 436717006043 putative DNA-binding cleft [nucleotide binding]; other site 436717006044 dimer interface [polypeptide binding]; other site 436717006045 Uncharacterized conserved protein [Function unknown]; Region: COG0062 436717006046 putative carbohydrate kinase; Provisional; Region: PRK10565 436717006047 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 436717006048 putative substrate binding site [chemical binding]; other site 436717006049 putative ATP binding site [chemical binding]; other site 436717006050 epoxyqueuosine reductase; Region: TIGR00276 436717006051 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 436717006052 biotin synthase; Provisional; Region: PRK15108 436717006053 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 436717006054 FeS/SAM binding site; other site 436717006055 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 436717006056 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 436717006057 putative chaperone protein EcpD; Provisional; Region: PRK09926 436717006058 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 436717006059 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 436717006060 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 436717006061 PapC N-terminal domain; Region: PapC_N; pfam13954 436717006062 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 436717006063 PapC C-terminal domain; Region: PapC_C; pfam13953 436717006064 putative major fimbrial protein SthE; Provisional; Region: PRK15292 436717006065 Fimbrial protein; Region: Fimbrial; pfam00419 436717006066 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 436717006067 Helix-turn-helix domain; Region: HTH_18; pfam12833 436717006068 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 436717006069 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 436717006070 Transcriptional regulator [Transcription]; Region: LysR; COG0583 436717006071 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 436717006072 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 436717006073 dimerization interface [polypeptide binding]; other site 436717006074 EamA-like transporter family; Region: EamA; pfam00892 436717006075 Purine-cytosine permease and related proteins [Nucleotide transport and metabolism]; Region: CodB; COG1457 436717006076 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 436717006077 Na binding site [ion binding]; other site 436717006078 Predicted membrane protein [Function unknown]; Region: COG4125 436717006079 Bacterial Transmembrane Pair family; Region: BTP; pfam05232 436717006080 Bacterial Transmembrane Pair family; Region: BTP; pfam05232 436717006081 Transcriptional regulator [Transcription]; Region: LysR; COG0583 436717006082 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 436717006083 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 436717006084 dimerization interface [polypeptide binding]; other site 436717006085 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 436717006086 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 436717006087 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown ABO13168; Region: LPLAT_ABO13168-like; cd07988 436717006088 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 436717006089 putative acyl-acceptor binding pocket; other site 436717006090 hypothetical protein; Validated; Region: PRK00110 436717006091 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 436717006092 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 436717006093 putative DNA binding site [nucleotide binding]; other site 436717006094 putative Zn2+ binding site [ion binding]; other site 436717006095 AsnC family; Region: AsnC_trans_reg; pfam01037 436717006096 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 436717006097 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 436717006098 Walker A/P-loop; other site 436717006099 ATP binding site [chemical binding]; other site 436717006100 Q-loop/lid; other site 436717006101 ABC transporter signature motif; other site 436717006102 Walker B; other site 436717006103 D-loop; other site 436717006104 H-loop/switch region; other site 436717006105 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 436717006106 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 436717006107 dimer interface [polypeptide binding]; other site 436717006108 conserved gate region; other site 436717006109 putative PBP binding loops; other site 436717006110 ABC-ATPase subunit interface; other site 436717006111 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 436717006112 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 436717006113 dimer interface [polypeptide binding]; other site 436717006114 conserved gate region; other site 436717006115 putative PBP binding loops; other site 436717006116 ABC-ATPase subunit interface; other site 436717006117 glutamate and aspartate transporter subunit; Provisional; Region: PRK10797 436717006118 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 436717006119 substrate binding pocket [chemical binding]; other site 436717006120 membrane-bound complex binding site; other site 436717006121 hinge residues; other site 436717006122 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 436717006123 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 436717006124 C-terminal domain interface [polypeptide binding]; other site 436717006125 GSH binding site (G-site) [chemical binding]; other site 436717006126 dimer interface [polypeptide binding]; other site 436717006127 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 436717006128 N-terminal domain interface [polypeptide binding]; other site 436717006129 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 436717006130 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 436717006131 active site 436717006132 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 436717006133 Dibenzothiophene (DBT) desulfurization enzyme C; Region: DszC; cd01163 436717006134 Flavin binding site [chemical binding]; other site 436717006135 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 436717006136 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 436717006137 active site 436717006138 non-prolyl cis peptide bond; other site 436717006139 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 436717006140 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 436717006141 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 436717006142 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 436717006143 Walker A/P-loop; other site 436717006144 ATP binding site [chemical binding]; other site 436717006145 Q-loop/lid; other site 436717006146 ABC transporter signature motif; other site 436717006147 Walker B; other site 436717006148 D-loop; other site 436717006149 H-loop/switch region; other site 436717006150 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 436717006151 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 436717006152 dimer interface [polypeptide binding]; other site 436717006153 conserved gate region; other site 436717006154 ABC-ATPase subunit interface; other site 436717006155 GTP-binding protein YchF; Reviewed; Region: PRK09601 436717006156 YchF GTPase; Region: YchF; cd01900 436717006157 G1 box; other site 436717006158 GTP/Mg2+ binding site [chemical binding]; other site 436717006159 Switch I region; other site 436717006160 G2 box; other site 436717006161 Switch II region; other site 436717006162 G3 box; other site 436717006163 G4 box; other site 436717006164 G5 box; other site 436717006165 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 436717006166 Protein of unknown function (DUF962); Region: DUF962; cl01879 436717006167 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 436717006168 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 436717006169 ligand binding site [chemical binding]; other site 436717006170 flexible hinge region; other site 436717006171 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 436717006172 putative switch regulator; other site 436717006173 non-specific DNA interactions [nucleotide binding]; other site 436717006174 DNA binding site [nucleotide binding] 436717006175 sequence specific DNA binding site [nucleotide binding]; other site 436717006176 putative cAMP binding site [chemical binding]; other site 436717006177 AzlC protein; Region: AzlC; cl00570 436717006178 putative L-valine exporter; Provisional; Region: PRK10408 436717006179 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 436717006180 active site 1 [active] 436717006181 dimer interface [polypeptide binding]; other site 436717006182 hexamer interface [polypeptide binding]; other site 436717006183 active site 2 [active] 436717006184 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 436717006185 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 436717006186 ATP-grasp domain; Region: ATP-grasp; pfam02222 436717006187 PII uridylyl-transferase; Provisional; Region: glnD; PRK00275 436717006188 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 436717006189 metal binding triad; other site 436717006190 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 436717006191 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 436717006192 Zn2+ binding site [ion binding]; other site 436717006193 Mg2+ binding site [ion binding]; other site 436717006194 ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900 436717006195 C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899 436717006196 succinyldiaminopimelate transaminase; Provisional; Region: PRK09147 436717006197 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 436717006198 pyridoxal 5'-phosphate binding site [chemical binding]; other site 436717006199 homodimer interface [polypeptide binding]; other site 436717006200 catalytic residue [active] 436717006201 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 436717006202 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 436717006203 HTH domain; Region: HTH_11; cl17392 436717006204 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 436717006205 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 436717006206 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 436717006207 catalytic residues [active] 436717006208 dimer interface [polypeptide binding]; other site 436717006209 methionine sulfoxide reductase B; Provisional; Region: PRK00222 436717006210 SelR domain; Region: SelR; pfam01641 436717006211 aminotransferase AlaT; Validated; Region: PRK09265 436717006212 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 436717006213 pyridoxal 5'-phosphate binding site [chemical binding]; other site 436717006214 homodimer interface [polypeptide binding]; other site 436717006215 catalytic residue [active] 436717006216 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 436717006217 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 436717006218 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 436717006219 active site 436717006220 homodimer interface [polypeptide binding]; other site 436717006221 homotetramer interface [polypeptide binding]; other site 436717006222 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433 436717006223 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 436717006224 putative active site [active] 436717006225 putative PHP Thumb interface [polypeptide binding]; other site 436717006226 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 436717006227 generic binding surface I; other site 436717006228 generic binding surface II; other site 436717006229 rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565 436717006230 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 436717006231 serine O-acetyltransferase; Region: cysE; TIGR01172 436717006232 Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762 436717006233 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 436717006234 trimer interface [polypeptide binding]; other site 436717006235 active site 436717006236 substrate binding site [chemical binding]; other site 436717006237 CoA binding site [chemical binding]; other site 436717006238 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 436717006239 PGAP1-like protein; Region: PGAP1; pfam07819 436717006240 alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317 436717006241 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974 436717006242 catalytic residue [active] 436717006243 TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026 436717006244 catalytic residues [active] 436717006245 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 436717006246 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 436717006247 Chromate transporter; Region: Chromate_transp; pfam02417 436717006248 Chromate transporter; Region: Chromate_transp; pfam02417 436717006249 Transcriptional regulator [Transcription]; Region: LysR; COG0583 436717006250 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 436717006251 The C-terminal substrate binding domain of LysR-type transcrptional regulator BudR, which is responsible for activation of the expression of the butanediol operon genes; contains the type 2 periplasmic binding fold; Region: PBP2_BudR; cd08451 436717006252 putative dimerization interface [polypeptide binding]; other site 436717006253 putative substrate binding pocket [chemical binding]; other site 436717006254 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 436717006255 arsenical-resistance protein; Region: acr3; TIGR00832 436717006256 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 436717006257 dimerization interface [polypeptide binding]; other site 436717006258 putative DNA binding site [nucleotide binding]; other site 436717006259 putative Zn2+ binding site [ion binding]; other site 436717006260 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 436717006261 ArsC family; Region: ArsC; pfam03960 436717006262 catalytic residues [active] 436717006263 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 436717006264 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 436717006265 active site 436717006266 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 436717006267 Isochorismatase family; Region: Isochorismatase; pfam00857 436717006268 catalytic triad [active] 436717006269 dimer interface [polypeptide binding]; other site 436717006270 conserved cis-peptide bond; other site 436717006271 Transcriptional regulator [Transcription]; Region: LysR; COG0583 436717006272 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 436717006273 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 436717006274 putative effector binding pocket; other site 436717006275 dimerization interface [polypeptide binding]; other site 436717006276 Transcriptional regulators [Transcription]; Region: GntR; COG1802 436717006277 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 436717006278 DNA-binding site [nucleotide binding]; DNA binding site 436717006279 FCD domain; Region: FCD; pfam07729 436717006280 uncharacterized nucleobase-cation-symport-1 (NCS1) transporter subfamily; solute-binding domain; Region: SLC-NCS1sbd_u1; cd11555 436717006281 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 436717006282 Na binding site [ion binding]; other site 436717006283 putative substrate binding site [chemical binding]; other site 436717006284 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 436717006285 taurine dioxygenase; Reviewed; Region: tauD; PRK09553 436717006286 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 436717006287 active site 436717006288 iron coordination sites [ion binding]; other site 436717006289 substrate binding pocket [chemical binding]; other site 436717006290 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 436717006291 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 436717006292 dimer interface [polypeptide binding]; other site 436717006293 conserved gate region; other site 436717006294 putative PBP binding loops; other site 436717006295 ABC-ATPase subunit interface; other site 436717006296 taurine transporter ATP-binding subunit; Provisional; Region: tauB; PRK11248 436717006297 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 436717006298 Walker A/P-loop; other site 436717006299 ATP binding site [chemical binding]; other site 436717006300 Q-loop/lid; other site 436717006301 ABC transporter signature motif; other site 436717006302 Walker B; other site 436717006303 D-loop; other site 436717006304 H-loop/switch region; other site 436717006305 taurine ABC transporter, periplasmic binding protein; Region: taurine_ABC_bnd; TIGR01729 436717006306 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 436717006307 substrate binding pocket [chemical binding]; other site 436717006308 membrane-bound complex binding site; other site 436717006309 hinge residues; other site 436717006310 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 436717006311 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 436717006312 putative substrate translocation pore; other site 436717006313 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 436717006314 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 436717006315 active site 436717006316 non-prolyl cis peptide bond; other site 436717006317 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 436717006318 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 436717006319 active site 436717006320 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 436717006321 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 436717006322 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 436717006323 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 436717006324 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 436717006325 DNA-binding site [nucleotide binding]; DNA binding site 436717006326 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 436717006327 pyridoxal 5'-phosphate binding site [chemical binding]; other site 436717006328 homodimer interface [polypeptide binding]; other site 436717006329 catalytic residue [active] 436717006330 Transcriptional regulator [Transcription]; Region: LysR; COG0583 436717006331 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 436717006332 The C-terminal substrate-binding domian of LysR-type transcriptional regulator MdcR, which involved in the malonate catabolism contains the type 2 periplasmic binding fold; Region: PBP2_MdcR; cd08416 436717006333 putative dimerization interface [polypeptide binding]; other site 436717006334 malonate transporter, MadM subunit; Region: malonate_madM; TIGR00808 436717006335 Malonate transporter MadL subunit; Region: MadL; cl04273 436717006336 malonate decarboxylase, epsilon subunit; Region: malonate_mdcH; TIGR03131 436717006337 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 436717006338 phosphoribosyl-dephospho-CoA transferase; Provisional; Region: PRK01293 436717006339 Phosphoribosyl-dephospho-CoA transferase MdcG; Region: MdcG; pfam10620 436717006340 malonate decarboxylase, gamma subunit; Region: malonate_gamma; TIGR03134 436717006341 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189 436717006342 malonate decarboxylase subunit delta; Provisional; Region: PRK01220 436717006343 triphosphoribosyl-dephospho-CoA synthase; Validated; Region: PRK01237 436717006344 malonate decarboxylase, alpha subunit; Region: mdcA; TIGR01110 436717006345 Major Facilitator Superfamily; Region: MFS_1; pfam07690 436717006346 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 436717006347 putative substrate translocation pore; other site 436717006348 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 436717006349 Transcriptional regulator [Transcription]; Region: PaiB; COG2808 436717006350 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 436717006351 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 436717006352 DNA-binding site [nucleotide binding]; DNA binding site 436717006353 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 436717006354 pyridoxal 5'-phosphate binding site [chemical binding]; other site 436717006355 homodimer interface [polypeptide binding]; other site 436717006356 catalytic residue [active] 436717006357 Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346 436717006358 LrgA family; Region: LrgA; cl00608 436717006359 Transcriptional regulator [Transcription]; Region: LysR; COG0583 436717006360 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 436717006361 The C-terminal substrate binding domain of LysR-like transcriptional regulator CidR, contains the type 2 periplasmic binding fold; Region: PBP2_CidR; cd08438 436717006362 putative dimerization interface [polypeptide binding]; other site 436717006363 glutathione S-transferase; Provisional; Region: PRK15113 436717006364 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 436717006365 C-terminal domain interface [polypeptide binding]; other site 436717006366 GSH binding site (G-site) [chemical binding]; other site 436717006367 dimer interface [polypeptide binding]; other site 436717006368 C-terminal, alpha helical domain of an unknown subfamily 4 of Glutathione S-transferases; Region: GST_C_4; cd03195 436717006369 putative dimer interface [polypeptide binding]; other site 436717006370 N-terminal domain interface [polypeptide binding]; other site 436717006371 putative substrate binding pocket (H-site) [chemical binding]; other site 436717006372 putative S-transferase; Provisional; Region: PRK11752 436717006373 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 436717006374 C-terminal domain interface [polypeptide binding]; other site 436717006375 GSH binding site (G-site) [chemical binding]; other site 436717006376 dimer interface [polypeptide binding]; other site 436717006377 C-terminal, alpha helical domain of Escherichia coli Yghu Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YghU_like; cd10292 436717006378 dimer interface [polypeptide binding]; other site 436717006379 N-terminal domain interface [polypeptide binding]; other site 436717006380 active site 436717006381 Protein of unknown function (DUF2000); Region: DUF2000; pfam09391 436717006382 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 436717006383 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 436717006384 Helix-turn-helix domain; Region: HTH_18; pfam12833 436717006385 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 436717006386 Transcriptional regulator [Transcription]; Region: LysR; COG0583 436717006387 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 436717006388 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 436717006389 putative effector binding pocket; other site 436717006390 putative dimerization interface [polypeptide binding]; other site 436717006391 short chain dehydrogenase; Provisional; Region: PRK12937 436717006392 tetrahydroxynaphthalene/trihydroxynaphthalene reductase-like, classical (c) SDRs; Region: THN_reductase-like_SDR_c; cd05362 436717006393 NADP binding site [chemical binding]; other site 436717006394 homodimer interface [polypeptide binding]; other site 436717006395 active site 436717006396 substrate binding site [chemical binding]; other site 436717006397 Member of the Rhodanese Homology Domain superfamily, subgroup 1. This CD includes the putative rhodanese-related sulfurtransferases of several uncharacterized proteins; Region: RHOD_1; cd01522 436717006398 active site residue [active] 436717006399 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 436717006400 trimer interface [polypeptide binding]; other site 436717006401 active site 436717006402 substrate binding site [chemical binding]; other site 436717006403 CoA binding site [chemical binding]; other site 436717006404 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 436717006405 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 436717006406 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 436717006407 catalytic residue [active] 436717006408 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 436717006409 Transcriptional regulator [Transcription]; Region: LysR; COG0583 436717006410 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 436717006411 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 436717006412 putative effector binding pocket; other site 436717006413 dimerization interface [polypeptide binding]; other site 436717006414 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 436717006415 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 436717006416 substrate binding pocket [chemical binding]; other site 436717006417 membrane-bound complex binding site; other site 436717006418 hinge residues; other site 436717006419 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 436717006420 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 436717006421 substrate binding pocket [chemical binding]; other site 436717006422 membrane-bound complex binding site; other site 436717006423 hinge residues; other site 436717006424 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 436717006425 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 436717006426 Walker A/P-loop; other site 436717006427 ATP binding site [chemical binding]; other site 436717006428 Q-loop/lid; other site 436717006429 ABC transporter signature motif; other site 436717006430 Walker B; other site 436717006431 D-loop; other site 436717006432 H-loop/switch region; other site 436717006433 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 436717006434 dimer interface [polypeptide binding]; other site 436717006435 conserved gate region; other site 436717006436 putative PBP binding loops; other site 436717006437 ABC-ATPase subunit interface; other site 436717006438 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 436717006439 dimer interface [polypeptide binding]; other site 436717006440 conserved gate region; other site 436717006441 putative PBP binding loops; other site 436717006442 ABC-ATPase subunit interface; other site 436717006443 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 436717006444 Coenzyme A binding pocket [chemical binding]; other site 436717006445 ribonucleoside transporter; Reviewed; Region: nepI; PRK10213 436717006446 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 436717006447 putative substrate translocation pore; other site 436717006448 Transcriptional regulator [Transcription]; Region: LysR; COG0583 436717006449 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 436717006450 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 436717006451 putative effector binding pocket; other site 436717006452 putative dimerization interface [polypeptide binding]; other site 436717006453 Uncharacterized conserved protein [Function unknown]; Region: COG4925 436717006454 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 436717006455 Response regulator receiver domain; Region: Response_reg; pfam00072 436717006456 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 436717006457 active site 436717006458 phosphorylation site [posttranslational modification] 436717006459 intermolecular recognition site; other site 436717006460 dimerization interface [polypeptide binding]; other site 436717006461 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 436717006462 DNA binding residues [nucleotide binding] 436717006463 dimerization interface [polypeptide binding]; other site 436717006464 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 436717006465 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 436717006466 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 436717006467 dimer interface [polypeptide binding]; other site 436717006468 phosphorylation site [posttranslational modification] 436717006469 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 436717006470 ATP binding site [chemical binding]; other site 436717006471 Mg2+ binding site [ion binding]; other site 436717006472 G-X-G motif; other site 436717006473 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 436717006474 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 436717006475 active site 436717006476 phosphorylation site [posttranslational modification] 436717006477 intermolecular recognition site; other site 436717006478 dimerization interface [polypeptide binding]; other site 436717006479 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 436717006480 Na binding site [ion binding]; other site 436717006481 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 436717006482 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 436717006483 putative DNA binding site [nucleotide binding]; other site 436717006484 putative Zn2+ binding site [ion binding]; other site 436717006485 AsnC family; Region: AsnC_trans_reg; pfam01037 436717006486 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 436717006487 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 436717006488 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 436717006489 Catalytic site [active] 436717006490 Stress-induced bacterial acidophilic repeat motif; Region: KGG; pfam10685 436717006491 short chain dehydrogenase; Provisional; Region: PRK06701 436717006492 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 436717006493 NAD binding site [chemical binding]; other site 436717006494 metal binding site [ion binding]; metal-binding site 436717006495 active site 436717006496 hydroperoxidase II; Provisional; Region: katE; PRK11249 436717006497 Clade 2 of the heme-binding enzyme catalase; Region: catalase_clade_2; cd08155 436717006498 tetramer interface [polypeptide binding]; other site 436717006499 heme binding pocket [chemical binding]; other site 436717006500 Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132 436717006501 domain interactions; other site 436717006502 Competence-damaged protein; Region: CinA; pfam02464 436717006503 Transcriptional regulator [Transcription]; Region: LysR; COG0583 436717006504 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 436717006505 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 436717006506 putative effector binding pocket; other site 436717006507 dimerization interface [polypeptide binding]; other site 436717006508 SGNH_hydrolase subfamily, similar to the putative arylesterase/acylhydrolase from the rumen anaerobe Prevotella bryantii XynE. The P. bryantii XynE gene is located in a xylanase gene cluster. SGNH hydrolases are a diverse family of lipases and esterases; Region: XynE_like; cd01830 436717006509 active site 436717006510 catalytic triad [active] 436717006511 oxyanion hole [active] 436717006512 benzoate transport; Region: 2A0115; TIGR00895 436717006513 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 436717006514 putative substrate translocation pore; other site 436717006515 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 436717006516 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 436717006517 S-adenosylmethionine binding site [chemical binding]; other site 436717006518 AMP-binding domain protein; Validated; Region: PRK08315 436717006519 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 436717006520 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917 436717006521 acyl-activating enzyme (AAE) consensus motif; other site 436717006522 putative AMP binding site [chemical binding]; other site 436717006523 putative active site [active] 436717006524 putative CoA binding site [chemical binding]; other site 436717006525 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 436717006526 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 436717006527 isovaleryl-CoA dehydrogenase; Region: PLN02519 436717006528 Isovaleryl-CoA dehydrogenase; Region: IVD; cd01156 436717006529 substrate binding site [chemical binding]; other site 436717006530 FAD binding site [chemical binding]; other site 436717006531 catalytic base [active] 436717006532 3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820 436717006533 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 436717006534 enoyl-CoA hydratase; Provisional; Region: PRK05995 436717006535 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 436717006536 substrate binding site [chemical binding]; other site 436717006537 oxyanion hole (OAH) forming residues; other site 436717006538 trimer interface [polypeptide binding]; other site 436717006539 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 436717006540 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 436717006541 ATP-grasp domain; Region: ATP-grasp_4; cl17255 436717006542 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 436717006543 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 436717006544 carboxyltransferase (CT) interaction site; other site 436717006545 biotinylation site [posttranslational modification]; other site 436717006546 Isopropylmalate/homocitrate/citramalate synthases [Amino acid transport and metabolism]; Region: LeuA; COG0119 436717006547 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 436717006548 active site 436717006549 catalytic residues [active] 436717006550 metal binding site [ion binding]; metal-binding site 436717006551 Transcriptional regulator [Transcription]; Region: LysR; COG0583 436717006552 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 436717006553 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 436717006554 putative effector binding pocket; other site 436717006555 dimerization interface [polypeptide binding]; other site 436717006556 indolepyruvate ferredoxin oxidoreductase; Validated; Region: PRK09193 436717006557 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 436717006558 dimer interface [polypeptide binding]; other site 436717006559 PYR/PP interface [polypeptide binding]; other site 436717006560 TPP binding site [chemical binding]; other site 436717006561 substrate binding site [chemical binding]; other site 436717006562 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 436717006563 TPP-binding site [chemical binding]; other site 436717006564 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 436717006565 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 436717006566 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 436717006567 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 436717006568 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 436717006569 active site 436717006570 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 436717006571 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 436717006572 CoenzymeA binding site [chemical binding]; other site 436717006573 subunit interaction site [polypeptide binding]; other site 436717006574 PHB binding site; other site 436717006575 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 436717006576 Major Facilitator Superfamily; Region: MFS_1; pfam07690 436717006577 putative substrate translocation pore; other site 436717006578 Maltoporin periplasmic N-terminal extension; Region: Sugarporin_N; pfam11471 436717006579 Coenzyme A transferase; Region: CoA_trans; cl17247 436717006580 3-oxoacid CoA-transferase, A subunit; Region: pcaI_scoA_fam; TIGR02429 436717006581 benzoate transport; Region: 2A0115; TIGR00895 436717006582 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 436717006583 putative substrate translocation pore; other site 436717006584 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 436717006585 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 436717006586 active site 436717006587 enoyl-CoA hydratase; Provisional; Region: PRK08138 436717006588 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 436717006589 substrate binding site [chemical binding]; other site 436717006590 oxyanion hole (OAH) forming residues; other site 436717006591 trimer interface [polypeptide binding]; other site 436717006592 3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826 436717006593 classical (c) SDRs; Region: SDR_c; cd05233 436717006594 NAD(P) binding site [chemical binding]; other site 436717006595 active site 436717006596 3-hydroxy-acyl-CoA dehydrogenase; Validated; Region: PRK08268 436717006597 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 436717006598 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 436717006599 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 436717006600 acetyl-CoA acetyltransferase; Provisional; Region: PRK08131 436717006601 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 436717006602 dimer interface [polypeptide binding]; other site 436717006603 active site 436717006604 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 436717006605 Transcriptional regulator [Transcription]; Region: IclR; COG1414 436717006606 Bacterial transcriptional regulator; Region: IclR; pfam01614 436717006607 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 436717006608 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 436717006609 putative substrate translocation pore; other site 436717006610 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 436717006611 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 436717006612 FMN binding site [chemical binding]; other site 436717006613 substrate binding site [chemical binding]; other site 436717006614 putative catalytic residue [active] 436717006615 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 436717006616 enoyl-CoA hydratase; Provisional; Region: PRK06688 436717006617 substrate binding site [chemical binding]; other site 436717006618 oxyanion hole (OAH) forming residues; other site 436717006619 trimer interface [polypeptide binding]; other site 436717006620 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 436717006621 Transcriptional regulator [Transcription]; Region: IclR; COG1414 436717006622 Bacterial transcriptional regulator; Region: IclR; pfam01614 436717006623 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 436717006624 CoA-transferase family III; Region: CoA_transf_3; pfam02515 436717006625 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 436717006626 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 436717006627 active site 436717006628 benzoate transport; Region: 2A0115; TIGR00895 436717006629 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 436717006630 putative substrate translocation pore; other site 436717006631 phosphonoacetaldehyde hydrolase; Provisional; Region: PRK13478 436717006632 2-aminoethylphosphonate--pyruvate transaminase; Provisional; Region: PRK13479 436717006633 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 436717006634 catalytic residue [active] 436717006635 FAD dependent oxidoreductase TIGR03364; Region: HpnW_proposed 436717006636 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 436717006637 potential frameshift: common BLAST hit: gi|126641408|ref|YP_001084392.1| ABC-type Fe3+ transport system permease component 436717006638 putative 2-aminoethylphosphonate ABC transporter, ATP-binding protein; Region: PhnT2; TIGR03265 436717006639 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 436717006640 Walker A/P-loop; other site 436717006641 ATP binding site [chemical binding]; other site 436717006642 Q-loop/lid; other site 436717006643 ABC transporter signature motif; other site 436717006644 Walker B; other site 436717006645 D-loop; other site 436717006646 H-loop/switch region; other site 436717006647 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 436717006648 ABC-type thiamine transport system, periplasmic component [Coenzyme metabolism]; Region: TbpA; COG4143 436717006649 transcriptional regulator protein; Region: phnR; TIGR03337 436717006650 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 436717006651 DNA-binding site [nucleotide binding]; DNA binding site 436717006652 UTRA domain; Region: UTRA; pfam07702 436717006653 4-hydroxybenzoate 3-monooxygenase; Validated; Region: PRK08243 436717006654 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 436717006655 NAD(P) binding site [chemical binding]; other site 436717006656 beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Region: pcaR_pcaU; TIGR02431 436717006657 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 436717006658 Bacterial transcriptional regulator; Region: IclR; pfam01614 436717006659 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 436717006660 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 436717006661 Transcriptional regulator [Transcription]; Region: LysR; COG0583 436717006662 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 436717006663 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_6; cd08475 436717006664 putative effector binding pocket; other site 436717006665 putative dimerization interface [polypeptide binding]; other site 436717006666 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 436717006667 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 436717006668 putative GTP cyclohydrolase; Provisional; Region: PRK13674 436717006669 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 436717006670 Gamma carbonic anhydrases (CA): Carbonic anhydrases are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism, involving the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide, followed...; Region: LbH_gamma_CA; cd00710 436717006671 trimer interface [polypeptide binding]; other site 436717006672 active site 436717006673 dihydroorotase; Reviewed; Region: PRK09236 436717006674 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 436717006675 Dihydroorotase (DHOase), subgroup IIb; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This group contains the archeal members of the DHOase family; Region: DHOase_IIb; cd01318 436717006676 active site 436717006677 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 436717006678 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 436717006679 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 436717006680 amino acid transporter; Region: 2A0306; TIGR00909 436717006681 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 436717006682 Alpha-Ketoglutaric Semialdehyde Dehydrogenase; Region: ALDH_KGSADH; cd07129 436717006683 dimer interface [polypeptide binding]; other site 436717006684 NADP binding site [chemical binding]; other site 436717006685 catalytic residues [active] 436717006686 metabolite-proton symporter; Region: 2A0106; TIGR00883 436717006687 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 436717006688 putative substrate translocation pore; other site 436717006689 PAS fold; Region: PAS_4; pfam08448 436717006690 Helix-turn-helix domain; Region: HTH_18; pfam12833 436717006691 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 436717006692 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 436717006693 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 436717006694 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510 436717006695 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 436717006696 hydroxyglutarate oxidase; Provisional; Region: PRK11728 436717006697 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 436717006698 hydroxyproline-2-epimerase; Provisional; Region: PRK13970 436717006699 hydroxyproline-2-epimerase; Provisional; Region: PRK13971 436717006700 Transcriptional regulators [Transcription]; Region: GntR; COG1802 436717006701 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 436717006702 DNA-binding site [nucleotide binding]; DNA binding site 436717006703 FCD domain; Region: FCD; pfam07729 436717006704 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 436717006705 EamA-like transporter family; Region: EamA; cl17759 436717006706 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 436717006707 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 436717006708 inhibitor site; inhibition site 436717006709 active site 436717006710 dimer interface [polypeptide binding]; other site 436717006711 catalytic residue [active] 436717006712 Putative hemolysin [General function prediction only]; Region: Hlx; COG3042 436717006713 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 436717006714 Domain of unknown function (DUF333); Region: DUF333; pfam03891 436717006715 Peptidase inhibitor I78 family; Region: Inhibitor_I78; pfam11720 436717006716 redox-sensitive transcriptional activator SoxR; Region: SoxR; TIGR01950 436717006717 Helix-Turn-Helix DNA binding domain of the SoxR transcription regulator; Region: HTH_SoxR; cd01110 436717006718 DNA binding residues [nucleotide binding] 436717006719 dimer interface [polypeptide binding]; other site 436717006720 [2Fe-2S] cluster binding site [ion binding]; other site 436717006721 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1636 436717006722 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 436717006723 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 436717006724 DNA-binding site [nucleotide binding]; DNA binding site 436717006725 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 436717006726 pyridoxal 5'-phosphate binding site [chemical binding]; other site 436717006727 homodimer interface [polypeptide binding]; other site 436717006728 catalytic residue [active] 436717006729 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 436717006730 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 436717006731 Coenzyme A binding pocket [chemical binding]; other site 436717006732 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214 436717006733 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 436717006734 putative cyanate transporter; Provisional; Region: cynX; PRK09705 436717006735 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 436717006736 nucleoside/Zn binding site; other site 436717006737 dimer interface [polypeptide binding]; other site 436717006738 catalytic motif [active] 436717006739 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 436717006740 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 436717006741 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 436717006742 Transcriptional regulator [Transcription]; Region: LysR; COG0583 436717006743 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 436717006744 LysR substrate binding domain; Region: LysR_substrate; pfam03466 436717006745 dimerization interface [polypeptide binding]; other site 436717006746 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 436717006747 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_M15_4; pfam13539 436717006748 type IV / VI secretion system protein, DotU family; Region: IV_VI_DotU; TIGR03349 436717006749 type VI secretion protein, VC_A0114 family; Region: VI_chp_4; TIGR03353 436717006750 Bacterial protein of unknown function (DUF876); Region: DUF876; pfam05936 436717006751 type VI secretion-associated protein, ImpA family; Region: VI_chp_8; TIGR03363 436717006752 ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812 436717006753 type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345 436717006754 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 436717006755 Walker A motif; other site 436717006756 ATP binding site [chemical binding]; other site 436717006757 Walker B motif; other site 436717006758 arginine finger; other site 436717006759 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 436717006760 Walker A motif; other site 436717006761 ATP binding site [chemical binding]; other site 436717006762 Walker B motif; other site 436717006763 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 436717006764 PAAR motif; Region: PAAR_motif; pfam05488 436717006765 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 436717006766 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 436717006767 ligand binding site [chemical binding]; other site 436717006768 Uncharacterized protein conserved in bacteria (DUF2094); Region: DUF2094; cl01611 436717006769 Type VI protein secretion system component VasK [Intracellular trafficking, secretion, and vesicular transport]; Region: IcmF; COG3523 436717006770 Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761 436717006771 Protein of unknown function (DUF1215); Region: DUF1215; pfam06744 436717006772 Protein of unknown function (DUF1305); Region: DUF1305; pfam06996 436717006773 Type VI protein secretion system component VasA [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3519 436717006774 Bacterial protein of unknown function (DUF879); Region: DUF879; cl15462 436717006775 type VI secretion system lysozyme-like protein; Region: VI_zyme; TIGR03357 436717006776 Protein of unknown function (DUF796); Region: DUF796; pfam05638 436717006777 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3517; cl05484 436717006778 Protein of unknown function (DUF877); Region: DUF877; pfam05943 436717006779 Protein of unknown function (DUF770); Region: DUF770; pfam05591 436717006780 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 436717006781 Sel1-like repeats; Region: SEL1; smart00671 436717006782 Sel1-like repeats; Region: SEL1; smart00671 436717006783 Sel1-like repeats; Region: SEL1; smart00671 436717006784 Sel1 repeat; Region: Sel1; pfam08238 436717006785 Sel1-like repeats; Region: SEL1; smart00671 436717006786 Sel1-like repeats; Region: SEL1; smart00671 436717006787 Uncharacterized protein conserved in bacteria [Function unknown]; Region: VgrG; COG3501 436717006788 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 436717006789 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 436717006790 Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296 436717006791 Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; pfam10106 436717006792 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 436717006793 RHS protein; Region: RHS; pfam03527 436717006794 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 436717006795 Domain of unknown function (DUF1910); Region: DUF1910; pfam08928 436717006796 Domain of unknown function (DUF1911); Region: DUF1911; pfam08929 436717006797 Uncharacterized protein conserved in bacteria [Function unknown]; Region: VgrG; COG3501 436717006798 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 436717006799 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 436717006800 Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296 436717006801 Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; pfam10106 436717006802 Transcriptional regulator [Transcription]; Region: LysR; COG0583 436717006803 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 436717006804 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 436717006805 putative effector binding pocket; other site 436717006806 dimerization interface [polypeptide binding]; other site 436717006807 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 436717006808 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 436717006809 putative substrate translocation pore; other site 436717006810 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4460 436717006811 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 436717006812 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 436717006813 dimer interface [polypeptide binding]; other site 436717006814 conserved gate region; other site 436717006815 putative PBP binding loops; other site 436717006816 ABC-ATPase subunit interface; other site 436717006817 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 436717006818 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 436717006819 Walker A/P-loop; other site 436717006820 ATP binding site [chemical binding]; other site 436717006821 Q-loop/lid; other site 436717006822 ABC transporter signature motif; other site 436717006823 Walker B; other site 436717006824 D-loop; other site 436717006825 H-loop/switch region; other site 436717006826 ABC transporter periplasmic binding protein, urea carboxylase region; Region: ABC_peri_uca; TIGR03427 436717006827 allophanate hydrolase; Provisional; Region: PRK08186 436717006828 Amidase; Region: Amidase; cl11426 436717006829 nickel responsive regulator; Provisional; Region: PRK04460 436717006830 NikR C terminal nickel binding domain; Region: NikR_C; pfam08753 436717006831 Predicted transcriptional regulators [Transcription]; Region: COG1733 436717006832 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 436717006833 dimerization interface [polypeptide binding]; other site 436717006834 putative Zn2+ binding site [ion binding]; other site 436717006835 putative DNA binding site [nucleotide binding]; other site 436717006836 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 436717006837 urea carboxylase; Region: urea_carbox; TIGR02712 436717006838 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 436717006839 ATP-grasp domain; Region: ATP-grasp_4; cl17255 436717006840 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 436717006841 Allophanate hydrolase subunit 2; Region: AHS2; smart00797 436717006842 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896 436717006843 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 436717006844 carboxyltransferase (CT) interaction site; other site 436717006845 biotinylation site [posttranslational modification]; other site 436717006846 urea carboxylase-associated protein 1; Region: urea_degr_1; TIGR03424 436717006847 Domain of unknown function (DUF1989); Region: DUF1989; pfam09347 436717006848 urea carboxylase-associated protein 1; Region: urea_degr_1; TIGR03424 436717006849 urea carboxylase-associated protein 2; Region: urea_degr_2; TIGR03425 436717006850 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 436717006851 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 436717006852 NAD binding site [chemical binding]; other site 436717006853 catalytic Zn binding site [ion binding]; other site 436717006854 structural Zn binding site [ion binding]; other site 436717006855 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07066 436717006856 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 436717006857 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 436717006858 aromatic amino acid exporter; Provisional; Region: PRK11689 436717006859 EamA-like transporter family; Region: EamA; pfam00892 436717006860 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 436717006861 putative hydrophobic ligand binding site [chemical binding]; other site 436717006862 protein interface [polypeptide binding]; other site 436717006863 gate; other site 436717006864 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 436717006865 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 436717006866 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 436717006867 ClC sycA-like chloride channel proteins. This ClC family presents in bacteria, where it facilitates acid resistance in acidic soil. Mutation of this gene (sycA) in Rhizobium tropici CIAT899 causes serious deficiencies in nodule development, nodulation...; Region: ClC_sycA_like; cd03682 436717006868 putative Cl- selectivity filter; other site 436717006869 putative pore gating glutamate residue; other site 436717006870 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 436717006871 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 436717006872 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 436717006873 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 436717006874 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 436717006875 carboxyltransferase (CT) interaction site; other site 436717006876 biotinylation site [posttranslational modification]; other site 436717006877 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 436717006878 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049 436717006879 Allophanate hydrolase subunit 2; Region: AHS2; pfam02626 436717006880 hypothetical protein; Provisional; Region: PRK05463 436717006881 LamB/YcsF family of lactam utilization protein; Region: LamB_YcsF_like; cd10787 436717006882 putative active site [active] 436717006883 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 436717006884 transcriptional regulator, ArgP family; Region: argP; TIGR03298 436717006885 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 436717006886 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 436717006887 dimerization interface [polypeptide binding]; other site 436717006888 Putative zinc-finger; Region: zf-HC2; pfam13490 436717006889 RNA polymerase sigma factor; Provisional; Region: PRK12544 436717006890 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 436717006891 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 436717006892 DNA binding residues [nucleotide binding] 436717006893 Uncharacterized protein conserved in bacteria (DUF2063); Region: DUF2063; cl01262 436717006894 hypothetical protein; Provisional; Region: PRK05409 436717006895 Predicted membrane protein [Function unknown]; Region: COG2259 436717006896 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 436717006897 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 436717006898 NAD(P) binding site [chemical binding]; other site 436717006899 active site 436717006900 Domain of unknown function (DUF4424); Region: DUF4424; pfam14415 436717006901 Beta-lactamase; Region: Beta-lactamase; pfam00144 436717006902 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 436717006903 Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966 436717006904 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 436717006905 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 436717006906 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 436717006907 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 436717006908 Transcriptional regulator [Transcription]; Region: LysR; COG0583 436717006909 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 436717006910 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 436717006911 putative effector binding pocket; other site 436717006912 putative dimerization interface [polypeptide binding]; other site 436717006913 Hydrolase of X-linked nucleoside diphosphate N terminal; Region: Nudix_N; pfam12535 436717006914 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_14; cd04672 436717006915 nudix motif; other site 436717006916 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 436717006917 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 436717006918 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 436717006919 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 436717006920 Metal-binding active site; metal-binding site 436717006921 AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582 436717006922 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 436717006923 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 436717006924 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 436717006925 PAP2, bacterial acid phosphatase or class A non-specific acid phosphatases. These enzymes catalyze phosphomonoester hydrolysis, with optimal activity in low pH conditions. They are secreted into the periplasmic space, and their physiological role remains...; Region: PAP2_acid_phosphatase; cd03397 436717006926 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 436717006927 active site 436717006928 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951 436717006929 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 436717006930 RNA polymerase sigma factor; Provisional; Region: PRK12528 436717006931 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 436717006932 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 436717006933 DNA binding residues [nucleotide binding] 436717006934 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 436717006935 FecR protein; Region: FecR; pfam04773 436717006936 Secretin and TonB N terminus short domain; Region: STN; smart00965 436717006937 Outer membrane receptor for ferric coprogen and ferric-rhodotorulic acid [Inorganic ion transport and metabolism]; Region: FhuE; COG4773 436717006938 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 436717006939 N-terminal plug; other site 436717006940 ligand-binding site [chemical binding]; other site 436717006941 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 436717006942 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 436717006943 tetramer interface [polypeptide binding]; other site 436717006944 active site 436717006945 Mg2+/Mn2+ binding site [ion binding]; other site 436717006946 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 436717006947 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 436717006948 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 436717006949 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 436717006950 N-terminal plug; other site 436717006951 ligand-binding site [chemical binding]; other site 436717006952 Uncharacterized protein family (UPF0180); Region: UPF0180; cl04214 436717006953 Uncharacterized secreted protein [Function unknown]; Region: COG5430 436717006954 Uncharacterized protein conserved in bacteria (DUF2147); Region: DUF2147; pfam09917 436717006955 taurine ABC transporter, periplasmic binding protein; Region: taurine_ABC_bnd; TIGR01729 436717006956 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 436717006957 substrate binding pocket [chemical binding]; other site 436717006958 membrane-bound complex binding site; other site 436717006959 hinge residues; other site 436717006960 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 436717006961 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 436717006962 dimer interface [polypeptide binding]; other site 436717006963 conserved gate region; other site 436717006964 putative PBP binding loops; other site 436717006965 ABC-ATPase subunit interface; other site 436717006966 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 436717006967 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 436717006968 Walker A/P-loop; other site 436717006969 ATP binding site [chemical binding]; other site 436717006970 Q-loop/lid; other site 436717006971 ABC transporter signature motif; other site 436717006972 Walker B; other site 436717006973 D-loop; other site 436717006974 H-loop/switch region; other site 436717006975 D-cysteine desulfhydrase; Validated; Region: PRK03910 436717006976 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 436717006977 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 436717006978 catalytic residue [active] 436717006979 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 436717006980 aspartate racemase; Region: asp_race; TIGR00035 436717006981 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 436717006982 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 436717006983 putative substrate translocation pore; other site 436717006984 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 436717006985 active site 436717006986 catalytic residues [active] 436717006987 metal binding site [ion binding]; metal-binding site 436717006988 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 436717006989 CoA-transferase family III; Region: CoA_transf_3; pfam02515 436717006990 Transcriptional regulator [Transcription]; Region: LysR; COG0583 436717006991 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 436717006992 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_1; cd08421 436717006993 putative dimerization interface [polypeptide binding]; other site 436717006994 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 436717006995 Catalase-like heme-binding proteins similar to the uncharacterized srpA; Region: srpA_like; cd08153 436717006996 putative heme binding pocket [chemical binding]; other site 436717006997 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 436717006998 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 436717006999 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 436717007000 DNA-binding site [nucleotide binding]; DNA binding site 436717007001 RNA-binding motif; other site 436717007002 Threonine/homoserine efflux transporter [Amino acid transport and metabolism]; Region: rhtA; COG5006 436717007003 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 436717007004 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 436717007005 putative DNA binding site [nucleotide binding]; other site 436717007006 putative Zn2+ binding site [ion binding]; other site 436717007007 AsnC family; Region: AsnC_trans_reg; pfam01037 436717007008 ethanolamine permease; Region: 2A0305; TIGR00908 436717007009 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 436717007010 active site 436717007011 substrate binding site [chemical binding]; other site 436717007012 Phosphotransferase enzyme family; Region: APH; pfam01636 436717007013 ATP binding site [chemical binding]; other site 436717007014 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 436717007015 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 436717007016 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 436717007017 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 436717007018 4-aminobutyrate aminotransferase and related aminotransferases [Amino acid transport and metabolism]; Region: GabT; COG0160 436717007019 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 436717007020 inhibitor-cofactor binding pocket; inhibition site 436717007021 pyridoxal 5'-phosphate binding site [chemical binding]; other site 436717007022 catalytic residue [active] 436717007023 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 436717007024 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 436717007025 Ribosomally synthesized peptide prototyped by Frankia Franean1_4349; Region: Frankia_peptide; pfam14407 436717007026 S-AdoMet dependent tetrapyrrole methylases; Region: TP_methylase; cl00304 436717007027 active site 436717007028 SAM binding site [chemical binding]; other site 436717007029 homodimer interface [polypeptide binding]; other site 436717007030 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312 436717007031 H+ Antiporter protein; Region: 2A0121; TIGR00900 436717007032 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 436717007033 CoenzymeA binding site [chemical binding]; other site 436717007034 subunit interaction site [polypeptide binding]; other site 436717007035 PHB binding site; other site 436717007036 phenylacetic acid degradation protein PaaY; Region: PaaY; TIGR02287 436717007037 paaY-like: This group is composed by uncharacterized proteins with similarity to the protein product of the E. coli paaY gene, which is part of the paa gene cluster responsible for phenylacetic acid degradation. Proteins in this group are expected to...; Region: LbH_paaY_like; cd04745 436717007038 putative trimer interface [polypeptide binding]; other site 436717007039 putative metal binding site [ion binding]; other site 436717007040 PaaX-like protein; Region: PaaX; pfam07848 436717007041 phenylacetic acid degradation operon negative regulatory protein PaaX; Region: PaaX_trns_reg; TIGR02277 436717007042 PaaX-like protein C-terminal domain; Region: PaaX_C; pfam08223 436717007043 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 436717007044 phenylacetate-CoA ligase; Region: PA_CoA_ligase; TIGR02155 436717007045 acyl-activating enzyme (AAE) consensus motif; other site 436717007046 AMP binding site [chemical binding]; other site 436717007047 active site 436717007048 CoA binding site [chemical binding]; other site 436717007049 beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050 436717007050 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 436717007051 dimer interface [polypeptide binding]; other site 436717007052 active site 436717007053 3-hydroxy-acyl-CoA dehydrogenase; Validated; Region: PRK08268 436717007054 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 436717007055 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 436717007056 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 436717007057 enoyl-CoA hydratase; Provisional; Region: PRK08140 436717007058 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 436717007059 substrate binding site [chemical binding]; other site 436717007060 oxyanion hole (OAH) forming residues; other site 436717007061 trimer interface [polypeptide binding]; other site 436717007062 enoyl-CoA hydratase-isomerase; Provisional; Region: PRK09674 436717007063 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 436717007064 substrate binding site [chemical binding]; other site 436717007065 oxyanion hole (OAH) forming residues; other site 436717007066 trimer interface [polypeptide binding]; other site 436717007067 phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160 436717007068 NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214 436717007069 FAD binding pocket [chemical binding]; other site 436717007070 FAD binding motif [chemical binding]; other site 436717007071 phosphate binding motif [ion binding]; other site 436717007072 beta-alpha-beta structure motif; other site 436717007073 NAD(p) ribose binding residues [chemical binding]; other site 436717007074 NAD binding pocket [chemical binding]; other site 436717007075 NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site 436717007076 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 436717007077 catalytic loop [active] 436717007078 iron binding site [ion binding]; other site 436717007079 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 436717007080 phenylacetate-CoA oxygenase, PaaJ subunit; Region: PA_CoA_Oxy4; TIGR02159 436717007081 Phenylacetic acid catabolic protein; Region: PaaA_PaaC; pfam05138 436717007082 phenylacetate-CoA oxygenase subunit PaaB; Provisional; Region: paaB; PRK13781 436717007083 phenylacetate-CoA oxygenase subunit PaaA; Provisional; Region: paaA; PRK13778 436717007084 phenylacetate-CoA oxygenase, PaaG subunit; Region: PA_CoA_Oxy1; TIGR02156 436717007085 bifunctional aldehyde dehydrogenase/enoyl-CoA hydratase; Provisional; Region: PRK11563 436717007086 N-terminal domain of the monoamine oxidase C dehydratase; Region: ALDH_MaoC-N; cd07128 436717007087 substrate binding site [chemical binding]; other site 436717007088 dimer interface [polypeptide binding]; other site 436717007089 NADP binding site [chemical binding]; other site 436717007090 catalytic residues [active] 436717007091 MaoC_C The C-terminal hot dog fold of the MaoC (monoamine oxidase C) dehydratase regulatory protein. Orthologs of MaoC include PaaZ [Escherichia coli] and PaaN [Pseudomonas putida], which are putative ring-opening enzymes involved in phenylacetic acid...; Region: MaoC_C; cd03452 436717007092 substrate binding site [chemical binding]; other site 436717007093 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 436717007094 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 436717007095 putative substrate translocation pore; other site 436717007096 Transcriptional regulator [Transcription]; Region: LysR; COG0583 436717007097 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 436717007098 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 436717007099 putative effector binding pocket; other site 436717007100 dimerization interface [polypeptide binding]; other site 436717007101 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 436717007102 MutS domain I; Region: MutS_I; pfam01624 436717007103 MutS domain II; Region: MutS_II; pfam05188 436717007104 MutS domain III; Region: MutS_III; pfam05192 436717007105 MutS domain V; Region: MutS_V; pfam00488 436717007106 Walker A/P-loop; other site 436717007107 ATP binding site [chemical binding]; other site 436717007108 Q-loop/lid; other site 436717007109 ABC transporter signature motif; other site 436717007110 Walker B; other site 436717007111 D-loop; other site 436717007112 H-loop/switch region; other site 436717007113 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 436717007114 Coenzyme A binding pocket [chemical binding]; other site 436717007115 Ferredoxin [Energy production and conversion]; Region: COG1146 436717007116 4Fe-4S binding domain; Region: Fer4; cl02805 436717007117 Domain of unknown function (DUF3470); Region: DUF3470; pfam11953 436717007118 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3108 436717007119 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 436717007120 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 436717007121 S-adenosylmethionine binding site [chemical binding]; other site 436717007122 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 436717007123 Ligand Binding Site [chemical binding]; other site 436717007124 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cd00208 436717007125 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 436717007126 putative trimer interface [polypeptide binding]; other site 436717007127 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 436717007128 trimer interface [polypeptide binding]; other site 436717007129 active site 436717007130 substrate binding site [chemical binding]; other site 436717007131 putative CoA binding site [chemical binding]; other site 436717007132 CoA binding site [chemical binding]; other site 436717007133 Uncharacterized conserved protein [Function unknown]; Region: COG1739 436717007134 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 436717007135 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 436717007136 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 436717007137 HlyD family secretion protein; Region: HlyD_3; pfam13437 436717007138 type I secretion system ATPase, LssB family; Region: type_I_sec_LssB; TIGR03375 436717007139 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 436717007140 ATP-binding cassette domain of bacteriocin exporters, subfamily C; Region: ABCC_bacteriocin_exporters; cd03245 436717007141 Walker A/P-loop; other site 436717007142 ATP binding site [chemical binding]; other site 436717007143 Q-loop/lid; other site 436717007144 ABC transporter signature motif; other site 436717007145 Walker B; other site 436717007146 D-loop; other site 436717007147 H-loop/switch region; other site 436717007148 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 436717007149 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 436717007150 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 436717007151 Walker A/P-loop; other site 436717007152 ATP binding site [chemical binding]; other site 436717007153 Q-loop/lid; other site 436717007154 ABC transporter signature motif; other site 436717007155 Walker B; other site 436717007156 D-loop; other site 436717007157 H-loop/switch region; other site 436717007158 lipopolysaccharide transport periplasmic protein LptA; Region: outer_YhbN_LptA; TIGR03002 436717007159 OstA-like protein; Region: OstA; pfam03968 436717007160 Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835 436717007161 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3117; cl01200 436717007162 HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662 436717007163 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 436717007164 active site 436717007165 motif I; other site 436717007166 motif II; other site 436717007167 D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892 436717007168 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 436717007169 putative active site [active] 436717007170 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 436717007171 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 436717007172 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 436717007173 active site 436717007174 HIGH motif; other site 436717007175 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 436717007176 KMSKS motif; other site 436717007177 Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963 436717007178 tRNA binding surface [nucleotide binding]; other site 436717007179 anticodon binding site; other site 436717007180 Preprotein translocase subunit SecB. SecB is a cytoplasmic component of the multisubunit membrane-bound enzyme termed Sec protein translocase, which is the main constituent of the General Secretory (type II) Pathway involved in translocation of nascent...; Region: Translocase_SecB; cl00251 436717007181 Predicted transcriptional regulators [Transcription]; Region: COG1733 436717007182 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 436717007183 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 436717007184 Major Facilitator Superfamily; Region: MFS_1; pfam07690 436717007185 putative substrate translocation pore; other site 436717007186 Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4705 436717007187 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 436717007188 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 436717007189 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 436717007190 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 436717007191 Old yellow enzyme (OYE)-related FMN binding domain, group 2. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_2_FMN; cd04733 436717007192 putative active site [active] 436717007193 putative FMN binding site [chemical binding]; other site 436717007194 putative substrate binding site [chemical binding]; other site 436717007195 putative catalytic residue [active] 436717007196 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 436717007197 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 436717007198 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687 436717007199 Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118 436717007200 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 436717007201 Mechanosensitive ion channel; Region: MS_channel; pfam00924 436717007202 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 436717007203 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 436717007204 active site 436717007205 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 436717007206 Methyltransferase domain; Region: Methyltransf_31; pfam13847 436717007207 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 436717007208 S-adenosylmethionine binding site [chemical binding]; other site 436717007209 GlcNAc-PI de-N-acetylase; Region: PIG-L; pfam02585 436717007210 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 436717007211 active site 436717007212 Uncharacterized protein conserved in bacteria (DUF2171); Region: DUF2171; pfam09939 436717007213 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 436717007214 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 436717007215 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687 436717007216 Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118 436717007217 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 436717007218 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 436717007219 Methyltransferase domain; Region: Methyltransf_23; pfam13489 436717007220 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 436717007221 S-adenosylmethionine binding site [chemical binding]; other site 436717007222 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 436717007223 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 436717007224 putative DNA binding site [nucleotide binding]; other site 436717007225 putative Zn2+ binding site [ion binding]; other site 436717007226 AsnC family; Region: AsnC_trans_reg; pfam01037 436717007227 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 436717007228 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 436717007229 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 436717007230 DNA-binding site [nucleotide binding]; DNA binding site 436717007231 RNA-binding motif; other site 436717007232 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 436717007233 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 436717007234 putative acyl-acceptor binding pocket; other site 436717007235 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 436717007236 Glycosyl hydrolase 108; Region: Glyco_hydro_108; pfam05838 436717007237 Predicted Peptidoglycan domain; Region: PG_binding_3; pfam09374 436717007238 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 436717007239 Predicted transcriptional regulator [Transcription]; Region: COG2932 436717007240 non-specific DNA binding site [nucleotide binding]; other site 436717007241 salt bridge; other site 436717007242 sequence-specific DNA binding site [nucleotide binding]; other site 436717007243 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 436717007244 Catalytic site [active] 436717007245 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 436717007246 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 436717007247 generic binding surface II; other site 436717007248 generic binding surface I; other site 436717007249 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 436717007250 Cysteine-rich 4 helical bundle widely conserved in bacteria; Region: DUF326; cd08026 436717007251 dimerization interface [polypeptide binding]; other site 436717007252 Uncharacterized conserved protein [Function unknown]; Region: COG3791 436717007253 Cu(I)-responsive transcriptional regulator; Region: CueR; TIGR02044 436717007254 Helix-Turn-Helix DNA binding domain of CueR-like transcription regulators; Region: HTH_CueR; cd01108 436717007255 DNA binding residues [nucleotide binding] 436717007256 dimer interface [polypeptide binding]; other site 436717007257 copper binding site [ion binding]; other site 436717007258 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 436717007259 metal-binding site [ion binding] 436717007260 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 436717007261 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 436717007262 metal-binding site [ion binding] 436717007263 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 436717007264 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 436717007265 motif II; other site 436717007266 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 436717007267 metal-binding site [ion binding] 436717007268 Activator of aromatic catabolism; Region: XylR_N; pfam06505 436717007269 V4R domain; Region: V4R; pfam02830 436717007270 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 436717007271 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 436717007272 Walker A motif; other site 436717007273 ATP binding site [chemical binding]; other site 436717007274 Walker B motif; other site 436717007275 arginine finger; other site 436717007276 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 436717007277 Phenol hydroxylase subunit; Region: Phenol_hyd_sub; pfam06099 436717007278 Aromatic and Alkene Monooxygenase Hydroxylase, subunit B, ferritin-like diiron-binding domain; Region: AAMH_B; cd01058 436717007279 dimerization interface [polypeptide binding]; other site 436717007280 MmoB/DmpM family; Region: MmoB_DmpM; pfam02406 436717007281 Aromatic and Alkene Monooxygenase Hydroxylase, subunit A, ferritin-like diiron-binding domain; Region: AAMH_A; cd01057 436717007282 dimerization interface [polypeptide binding]; other site 436717007283 putative path to active site cavity [active] 436717007284 diiron center [ion binding]; other site 436717007285 Phenol hydroxylase conserved region; Region: Phenol_monoox; pfam04663 436717007286 CDP-6-deoxy-delta-3,4-glucoseen reductase; Validated; Region: PRK07609 436717007287 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 436717007288 catalytic loop [active] 436717007289 iron binding site [ion binding]; other site 436717007290 Phenol 2-monooxygenase (phenol hydroxylase) is a flavoprotein monooxygenase, able to use molecular oxygen as a substrate in the microbial degredation of phenol. This protein is encoded by a single gene and uses a tightly bound FAD cofactor in the NAD(P)H...; Region: phenol_2-monooxygenase_like; cd06211 436717007291 FAD binding pocket [chemical binding]; other site 436717007292 FAD binding motif [chemical binding]; other site 436717007293 phosphate binding motif [ion binding]; other site 436717007294 beta-alpha-beta structure motif; other site 436717007295 NAD binding pocket [chemical binding]; other site 436717007296 Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; cl01768 436717007297 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 436717007298 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 436717007299 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 436717007300 dimerization interface [polypeptide binding]; other site 436717007301 benzoate 1,2-dioxygenase, large subunit; Region: benzo_1_2_benA; TIGR03229 436717007302 Rieske non-heme iron oxygenase (RO) family, 2-Halobenzoate 1,2-dioxygenase (HBDO) subfamily, N-terminal Rieske domain of the oxygenase alpha subunit; ROs comprise a large class of aromatic ring-hydroxylating dioxygenases that enable microorganisms to...; Region: Rieske_RO_Alpha_HBDO; cd03542 436717007303 C-terminal catalytic domain of the oxygenase alpha subunit of Pseudomonas resinovorans strain CA10 anthranilate 1,2-dioxygenase and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_AntDO-like; cd08879 436717007304 putative alpha subunit interface [polypeptide binding]; other site 436717007305 putative active site [active] 436717007306 putative substrate binding site [chemical binding]; other site 436717007307 Fe binding site [ion binding]; other site 436717007308 Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667 436717007309 inter-subunit interface; other site 436717007310 anthranilate dioxygenase reductase; Provisional; Region: antC; PRK11872 436717007311 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 436717007312 catalytic loop [active] 436717007313 iron binding site [ion binding]; other site 436717007314 Benzoate dioxygenase reductase (BenDO) FAD/NAD binding domain. Oxygenases oxidize hydrocarbons using dioxygen as the oxidant. As a Class I bacterial dioxygenases, benzoate dioxygenase like proteins combine an [2Fe-2S] cluster containing N-terminal...; Region: BenDO_FAD_NAD; cd06209 436717007315 FAD binding pocket [chemical binding]; other site 436717007316 FAD binding motif [chemical binding]; other site 436717007317 phosphate binding motif [ion binding]; other site 436717007318 beta-alpha-beta structure motif; other site 436717007319 NAD binding pocket [chemical binding]; other site 436717007320 1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate dehydrogenase; Provisional; Region: benD; PRK12823 436717007321 1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate dehydrogenase (DHB DH)-like, classical (c) SDR; Region: DHB_DH-like_SDR_c; cd08937 436717007322 putative NAD(P) binding site [chemical binding]; other site 436717007323 active site 436717007324 benzoate transporter; Region: benE; TIGR00843 436717007325 Benzoate membrane transport protein; Region: BenE; pfam03594 436717007326 benzoate transport; Region: 2A0115; TIGR00895 436717007327 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 436717007328 putative substrate translocation pore; other site 436717007329 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 436717007330 putative substrate translocation pore; other site 436717007331 outer membrane porin, OprD family; Region: OprD; pfam03573 436717007332 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK07515 436717007333 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 436717007334 dimer interface [polypeptide binding]; other site 436717007335 active site 436717007336 CoA binding pocket [chemical binding]; other site 436717007337 ATP-dependent helicase HrpA; Region: DEAH_box_HrpA; TIGR01967 436717007338 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 436717007339 ATP binding site [chemical binding]; other site 436717007340 putative Mg++ binding site [ion binding]; other site 436717007341 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 436717007342 nucleotide binding region [chemical binding]; other site 436717007343 ATP-binding site [chemical binding]; other site 436717007344 Helicase associated domain (HA2); Region: HA2; pfam04408 436717007345 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 436717007346 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 436717007347 peroxiredoxin; Region: AhpC; TIGR03137 436717007348 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 436717007349 dimer interface [polypeptide binding]; other site 436717007350 decamer (pentamer of dimers) interface [polypeptide binding]; other site 436717007351 catalytic triad [active] 436717007352 peroxidatic and resolving cysteines [active] 436717007353 KTSC domain; Region: KTSC; pfam13619 436717007354 Alkane hydroxylase is a bacterial, integral-membrane di-iron enzyme that shares a requirement for iron and oxygen for activity similar to that of the non-heme integral-membrane acyl coenzyme A (CoA) desaturases and acyl lipid desaturases. The alk genes...; Region: Alkane-hydroxylase; cd03512 436717007355 Fatty acid desaturase; Region: FA_desaturase; pfam00487 436717007356 Di-iron ligands [ion binding]; other site 436717007357 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 436717007358 Helix-turn-helix domain; Region: HTH_18; pfam12833 436717007359 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 436717007360 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 436717007361 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 436717007362 S-adenosylmethionine binding site [chemical binding]; other site 436717007363 Protein of unknown function (DUF1653); Region: DUF1653; pfam07866 436717007364 alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317 436717007365 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974 436717007366 catalytic residue [active] 436717007367 TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026 436717007368 catalytic residues [active] 436717007369 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 436717007370 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 436717007371 glutathionine S-transferase; Provisional; Region: PRK10542 436717007372 GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057 436717007373 C-terminal domain interface [polypeptide binding]; other site 436717007374 GSH binding site (G-site) [chemical binding]; other site 436717007375 dimer interface [polypeptide binding]; other site 436717007376 C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188 436717007377 dimer interface [polypeptide binding]; other site 436717007378 N-terminal domain interface [polypeptide binding]; other site 436717007379 substrate binding pocket (H-site) [chemical binding]; other site 436717007380 Predicted extracellular nuclease [General function prediction only]; Region: COG2374 436717007381 YhcR_OBF_like: A subfamily of OB-fold domains similar to the OB folds of Bacillus subtilis YhcR. YhcR is a sugar-nonspecific nuclease, which is active in the presence of Ca2+ and Mn2+. It cleaves RNA endonucleolytically, producing 3'-monophosphate...; Region: YhcR_OBF_like; cd04486 436717007382 generic binding surface II; other site 436717007383 generic binding surface I; other site 436717007384 Mycoplasma pulmonis MnuA nuclease-like; Region: MnuA_DNase1-like; cd10283 436717007385 putative active site [active] 436717007386 putative catalytic site [active] 436717007387 putative Mg binding site IVb [ion binding]; other site 436717007388 putative phosphate binding site [ion binding]; other site 436717007389 putative DNA binding site [nucleotide binding]; other site 436717007390 putative Mg binding site IVa [ion binding]; other site 436717007391 tRNA (guanine-N(7)-)-methyltransferase; Reviewed; Region: trmB; PRK00121 436717007392 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747 436717007393 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 436717007394 GST_N family, unknown subfamily 2; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_2; cd03047 436717007395 putative C-terminal domain interface [polypeptide binding]; other site 436717007396 putative GSH binding site (G-site) [chemical binding]; other site 436717007397 putative dimer interface [polypeptide binding]; other site 436717007398 C-terminal, alpha helical domain of an unknown subfamily 2 of Glutathione S-transferases; Region: GST_C_2; cd03180 436717007399 putative N-terminal domain interface [polypeptide binding]; other site 436717007400 putative dimer interface [polypeptide binding]; other site 436717007401 putative substrate binding pocket (H-site) [chemical binding]; other site 436717007402 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 436717007403 Domain of unknown function (DUF2520); Region: DUF2520; pfam10728 436717007404 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 436717007405 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 436717007406 ligand binding site [chemical binding]; other site 436717007407 dihydroorotase; Validated; Region: pyrC; PRK09357 436717007408 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 436717007409 active site 436717007410 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 436717007411 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 436717007412 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 436717007413 23S rRNA m(2)G2445 methyltransferase; Provisional; Region: rlmL; PRK11783 436717007414 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 436717007415 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 436717007416 DNA methylase; Region: N6_N4_Mtase; cl17433 436717007417 Competence-damaged protein; Region: CinA; pfam02464 436717007418 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 436717007419 Clp amino terminal domain; Region: Clp_N; pfam02861 436717007420 Clp amino terminal domain; Region: Clp_N; pfam02861 436717007421 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 436717007422 Walker A motif; other site 436717007423 ATP binding site [chemical binding]; other site 436717007424 Walker B motif; other site 436717007425 arginine finger; other site 436717007426 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 436717007427 Walker A motif; other site 436717007428 ATP binding site [chemical binding]; other site 436717007429 Walker B motif; other site 436717007430 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 436717007431 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 436717007432 Peptidase family M23; Region: Peptidase_M23; pfam01551 436717007433 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 436717007434 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 436717007435 Coenzyme A binding pocket [chemical binding]; other site 436717007436 OsmC-like protein; Region: OsmC; cl00767 436717007437 DNA-binding transcriptional dual regulator Crp; Provisional; Region: PRK11753 436717007438 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 436717007439 ligand binding site [chemical binding]; other site 436717007440 flexible hinge region; other site 436717007441 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 436717007442 putative switch regulator; other site 436717007443 non-specific DNA interactions [nucleotide binding]; other site 436717007444 DNA binding site [nucleotide binding] 436717007445 sequence specific DNA binding site [nucleotide binding]; other site 436717007446 putative cAMP binding site [chemical binding]; other site 436717007447 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 436717007448 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 436717007449 active site 436717007450 catalytic tetrad [active] 436717007451 Peptidase family M48; Region: Peptidase_M48; pfam01435 436717007452 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 436717007453 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 436717007454 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 436717007455 ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: PRK12421 436717007456 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 436717007457 dimer interface [polypeptide binding]; other site 436717007458 motif 1; other site 436717007459 active site 436717007460 motif 2; other site 436717007461 motif 3; other site 436717007462 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 436717007463 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 436717007464 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 436717007465 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 436717007466 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 436717007467 motif 1; other site 436717007468 active site 436717007469 motif 2; other site 436717007470 motif 3; other site 436717007471 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 436717007472 DHHA1 domain; Region: DHHA1; pfam02272 436717007473 aspartate kinase; Reviewed; Region: PRK06635 436717007474 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 436717007475 putative nucleotide binding site [chemical binding]; other site 436717007476 putative catalytic residues [active] 436717007477 putative Mg ion binding site [ion binding]; other site 436717007478 putative aspartate binding site [chemical binding]; other site 436717007479 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 436717007480 putative allosteric regulatory site; other site 436717007481 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 436717007482 carbon storage regulator; Provisional; Region: PRK01712 436717007483 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 436717007484 RNA/DNA hybrid binding site [nucleotide binding]; other site 436717007485 active site 436717007486 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 436717007487 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 436717007488 Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320 436717007489 active site 436717007490 purine riboside binding site [chemical binding]; other site 436717007491 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 436717007492 Pirin-related protein [General function prediction only]; Region: COG1741 436717007493 Pirin; Region: Pirin; pfam02678 436717007494 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 436717007495 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 436717007496 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687 436717007497 Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118 436717007498 classical (c) SDRs; Region: SDR_c; cd05233 436717007499 short chain dehydrogenase; Provisional; Region: PRK05650 436717007500 NAD(P) binding site [chemical binding]; other site 436717007501 active site 436717007502 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 436717007503 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 436717007504 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 436717007505 Leucine carboxyl methyltransferase; Region: LCM; pfam04072 436717007506 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 436717007507 transcriptional activator TtdR; Provisional; Region: PRK09801 436717007508 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_9; cd08479 436717007509 putative effector binding pocket; other site 436717007510 putative dimerization interface [polypeptide binding]; other site 436717007511 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 436717007512 D-galactonate transporter; Region: 2A0114; TIGR00893 436717007513 putative substrate translocation pore; other site 436717007514 tartrate dehydratase subunit alpha; Validated; Region: PRK08230 436717007515 L(+)-tartrate dehydratase subunit beta; Validated; Region: PRK08228 436717007516 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 436717007517 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 436717007518 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 436717007519 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 436717007520 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 436717007521 short chain dehydrogenase; Provisional; Region: PRK06181 436717007522 classical (c) SDRs; Region: SDR_c; cd05233 436717007523 NAD(P) binding site [chemical binding]; other site 436717007524 active site 436717007525 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 436717007526 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 436717007527 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 436717007528 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 436717007529 YcaO domain protein; Region: TIGR03549 436717007530 OsmC-like protein; Region: OsmC; pfam02566 436717007531 YcaO-like family; Region: YcaO; pfam02624 436717007532 outer membrane porin, OprD family; Region: OprD; pfam03573 436717007533 benzoate transport; Region: 2A0115; TIGR00895 436717007534 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 436717007535 putative substrate translocation pore; other site 436717007536 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 436717007537 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 436717007538 Sulfatase; Region: Sulfatase; pfam00884 436717007539 Uncharacterized conserved protein [Function unknown]; Region: COG1262 436717007540 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 436717007541 outer membrane porin, OprD family; Region: OprD; pfam03573 436717007542 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 436717007543 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 436717007544 iron-sulfur cluster [ion binding]; other site 436717007545 [2Fe-2S] cluster binding site [ion binding]; other site 436717007546 C-terminal catalytic domain of the oxygenase alpha subunit of dicamba O-demethylase and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_DMO-like; cd08878 436717007547 alpha subunit interface [polypeptide binding]; other site 436717007548 active site 436717007549 substrate binding site [chemical binding]; other site 436717007550 Fe binding site [ion binding]; other site 436717007551 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 436717007552 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 436717007553 FMN-binding pocket [chemical binding]; other site 436717007554 flavin binding motif; other site 436717007555 phosphate binding motif [ion binding]; other site 436717007556 beta-alpha-beta structure motif; other site 436717007557 NAD binding pocket [chemical binding]; other site 436717007558 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 436717007559 catalytic loop [active] 436717007560 iron binding site [ion binding]; other site 436717007561 Transcriptional regulators [Transcription]; Region: GntR; COG1802 436717007562 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 436717007563 DNA-binding site [nucleotide binding]; DNA binding site 436717007564 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 436717007565 MarR family; Region: MarR_2; pfam12802 436717007566 putative 3-hydroxyphenylpropionic transporter MhpT; Provisional; Region: PRK11551 436717007567 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 436717007568 putative substrate translocation pore; other site 436717007569 p-hydroxycinnamoyl CoA hydratase/lyase; Validated; Region: PRK09120 436717007570 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 436717007571 substrate binding site [chemical binding]; other site 436717007572 oxyanion hole (OAH) forming residues; other site 436717007573 trimer interface [polypeptide binding]; other site 436717007574 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 436717007575 Salicylaldehyde dehydrogenase, DoxF-like; Region: ALDH_SaliADH; cd07105 436717007576 NAD(P) binding site [chemical binding]; other site 436717007577 catalytic residues [active] 436717007578 feruloyl-CoA synthase; Reviewed; Region: PRK08180 436717007579 Feruloyl-CoA synthetase (FCS); Region: FCS; cd05921 436717007580 acyl-activating enzyme (AAE) consensus motif; other site 436717007581 putative AMP binding site [chemical binding]; other site 436717007582 putative active site [active] 436717007583 putative CoA binding site [chemical binding]; other site 436717007584 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 436717007585 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 436717007586 active site 436717007587 outer membrane porin, OprD family; Region: OprD; pfam03573 436717007588 Protein of unknown function (DUF3237); Region: DUF3237; pfam11578 436717007589 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 436717007590 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 436717007591 CoenzymeA binding site [chemical binding]; other site 436717007592 subunit interaction site [polypeptide binding]; other site 436717007593 PHB binding site; other site 436717007594 Tannase and feruloyl esterase; Region: Tannase; pfam07519 436717007595 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 436717007596 Transcriptional regulators [Transcription]; Region: FadR; COG2186 436717007597 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 436717007598 DNA-binding site [nucleotide binding]; DNA binding site 436717007599 FCD domain; Region: FCD; pfam07729 436717007600 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 436717007601 Alpha-Ketoglutaric Semialdehyde Dehydrogenase; Region: ALDH_KGSADH; cd07129 436717007602 dimer interface [polypeptide binding]; other site 436717007603 NADP binding site [chemical binding]; other site 436717007604 catalytic residues [active] 436717007605 5-dehydro-4-deoxyglucarate dehydratase, also called 5-keto-4-deoxy-glucarate dehydratase (KDGDH); Region: KDGDH; cd00951 436717007606 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 436717007607 putative active site [active] 436717007608 catalytic residue [active] 436717007609 glucarate dehydratase; Region: glucar-dehydr; TIGR03247 436717007610 D-Glucarate dehydratase (GlucD) catalyzes the dehydration of both D-glucarate and L-idarate to form 5-keto-4-deoxy-D-glucarate (5-KDG) , the initial reaction of the catabolic pathway for (D)-glucarate. GlucD belongs to the enolase superfamily of enzymes; Region: D-glucarate_dehydratase; cd03323 436717007611 active site 436717007612 tetramer interface [polypeptide binding]; other site 436717007613 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 436717007614 D-galactonate transporter; Region: 2A0114; TIGR00893 436717007615 putative substrate translocation pore; other site 436717007616 galactarate dehydratase; Region: galactar-dH20; TIGR03248 436717007617 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 436717007618 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 436717007619 EamA-like transporter family; Region: EamA; pfam00892 436717007620 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 436717007621 EamA-like transporter family; Region: EamA; pfam00892 436717007622 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 436717007623 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 436717007624 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 436717007625 aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381 436717007626 Coniferyl aldehyde dehydrogenase-like; Region: ALDH_CALDH_CalB; cd07133 436717007627 NAD(P) binding site [chemical binding]; other site 436717007628 catalytic residues [active] 436717007629 A nuclease family of the HNH/ENDO VII superfamily with conserved AHH; Region: AHH; pfam14412 436717007630 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 436717007631 LytTr DNA-binding domain; Region: LytTR; cl04498 436717007632 haemagglutination activity domain; Region: Haemagg_act; pfam05860 436717007633 Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; cl01733 436717007634 Possible hemagglutinin (DUF637); Region: DUF637; pfam04830 436717007635 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 436717007636 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 436717007637 Haemolysin secretion/activation protein ShlB/FhaC/HecB; Region: ShlB; pfam03865 436717007638 D-alanine/D-serine/glycine permease; Provisional; Region: PRK11049 436717007639 Arginine/ornithine N-succinyltransferase beta subunit [Amino acid transport and metabolism]; Region: AstA; COG3138 436717007640 Arginine N-succinyltransferase beta subunit; Region: AstA; cl11440 436717007641 bifunctional succinylornithine transaminase/acetylornithine transaminase; Provisional; Region: PRK12381 436717007642 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 436717007643 inhibitor-cofactor binding pocket; inhibition site 436717007644 pyridoxal 5'-phosphate binding site [chemical binding]; other site 436717007645 catalytic residue [active] 436717007646 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 436717007647 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 436717007648 AsnC family; Region: AsnC_trans_reg; pfam01037 436717007649 gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK13473 436717007650 Escherichia coli NAD+-dependent gamma-aminobutyraldehyde dehydrogenase YdcW-like; Region: ALDH_ABALDH-YdcW; cd07092 436717007651 tetrameric interface [polypeptide binding]; other site 436717007652 NAD binding site [chemical binding]; other site 436717007653 catalytic residues [active] 436717007654 substrate binding site [chemical binding]; other site 436717007655 SnoaL-like domain; Region: SnoaL_2; pfam12680 436717007656 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 436717007657 Transcriptional regulators [Transcription]; Region: FadR; COG2186 436717007658 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 436717007659 DNA-binding site [nucleotide binding]; DNA binding site 436717007660 FCD domain; Region: FCD; pfam07729 436717007661 Cache domain; Region: Cache_1; pfam02743 436717007662 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 436717007663 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 436717007664 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 436717007665 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 436717007666 Uncharacterized conserved protein (DUF2235); Region: DUF2235; pfam09994 436717007667 Domain of unknown function (DUF4123); Region: DUF4123; pfam13503 436717007668 Uncharacterized protein conserved in bacteria [Function unknown]; Region: VgrG; COG3501 436717007669 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 436717007670 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 436717007671 Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296 436717007672 Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; pfam10106 436717007673 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 436717007674 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 436717007675 Bacterial protein of unknown function (DUF898); Region: DUF898; pfam05987 436717007676 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 436717007677 FAD binding domain; Region: FAD_binding_3; pfam01494 436717007678 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 436717007679 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 436717007680 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 436717007681 2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930 436717007682 active site 436717007683 FMN binding site [chemical binding]; other site 436717007684 2,4-decadienoyl-CoA binding site; other site 436717007685 catalytic residue [active] 436717007686 4Fe-4S cluster binding site [ion binding]; other site 436717007687 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 436717007688 argininosuccinate synthase; Provisional; Region: PRK13820 436717007689 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 436717007690 ANP binding site [chemical binding]; other site 436717007691 Substrate Binding Site II [chemical binding]; other site 436717007692 Substrate Binding Site I [chemical binding]; other site 436717007693 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 436717007694 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 436717007695 metal binding site [ion binding]; metal-binding site 436717007696 active site 436717007697 I-site; other site 436717007698 Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294 436717007699 active site 436717007700 substrate binding pocket [chemical binding]; other site 436717007701 dimer interface [polypeptide binding]; other site 436717007702 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 436717007703 DEDDh 3'-5' exonuclease domain of RNase T; Region: RNaseT; cd06134 436717007704 dimer interface [polypeptide binding]; other site 436717007705 catalytic site [active] 436717007706 putative active site [active] 436717007707 putative substrate binding site [chemical binding]; other site 436717007708 Protein of unknown function (DUF2726); Region: DUF2726; pfam10881 436717007709 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 436717007710 Old yellow enzyme (OYE)-related FMN binding domain, group 2. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_2_FMN; cd04733 436717007711 putative active site [active] 436717007712 putative FMN binding site [chemical binding]; other site 436717007713 putative substrate binding site [chemical binding]; other site 436717007714 putative catalytic residue [active] 436717007715 ABC-type uncharacterized transport system, duplicated ATPase component [General function prediction only]; Region: COG4172 436717007716 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 436717007717 Walker A/P-loop; other site 436717007718 ATP binding site [chemical binding]; other site 436717007719 Q-loop/lid; other site 436717007720 ABC transporter signature motif; other site 436717007721 Walker B; other site 436717007722 D-loop; other site 436717007723 H-loop/switch region; other site 436717007724 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 436717007725 Walker A/P-loop; other site 436717007726 ATP binding site [chemical binding]; other site 436717007727 Q-loop/lid; other site 436717007728 ABC transporter signature motif; other site 436717007729 Walker B; other site 436717007730 D-loop; other site 436717007731 H-loop/switch region; other site 436717007732 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4239 436717007733 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 436717007734 dimer interface [polypeptide binding]; other site 436717007735 conserved gate region; other site 436717007736 putative PBP binding loops; other site 436717007737 ABC-ATPase subunit interface; other site 436717007738 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4174 436717007739 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 436717007740 dimer interface [polypeptide binding]; other site 436717007741 conserved gate region; other site 436717007742 putative PBP binding loops; other site 436717007743 ABC-ATPase subunit interface; other site 436717007744 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497 436717007745 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 436717007746 membrane-bound lytic murein transglycosylase D; Provisional; Region: mltD; PRK10783 436717007747 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 436717007748 N-acetyl-D-glucosamine binding site [chemical binding]; other site 436717007749 catalytic residue [active] 436717007750 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 436717007751 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 436717007752 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 436717007753 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 436717007754 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 436717007755 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 436717007756 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 436717007757 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 436717007758 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 436717007759 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 436717007760 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 436717007761 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 436717007762 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 436717007763 RNA/DNA hybrid binding site [nucleotide binding]; other site 436717007764 active site 436717007765 DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406 436717007766 DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131 436717007767 active site 436717007768 catalytic site [active] 436717007769 substrate binding site [chemical binding]; other site 436717007770 NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296 436717007771 NADH pyrophosphatase; Reviewed; Region: nudC; PRK00241 436717007772 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 436717007773 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 436717007774 putative NADH binding site [chemical binding]; other site 436717007775 putative active site [active] 436717007776 nudix motif; other site 436717007777 putative metal binding site [ion binding]; other site 436717007778 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 436717007779 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 436717007780 Predicted periplasmic or secreted lipoprotein [General function prediction only]; Region: OsmY; COG2823 436717007781 BON domain; Region: BON; pfam04972 436717007782 hypothetical protein; Provisional; Region: PRK14674 436717007783 Predicted methyltransferases [General function prediction only]; Region: COG0313 436717007784 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 436717007785 putative SAM binding site [chemical binding]; other site 436717007786 putative homodimer interface [polypeptide binding]; other site 436717007787 chromosome replication initiation inhibitor protein; Validated; Region: PRK03635 436717007788 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 436717007789 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 436717007790 dimerization interface [polypeptide binding]; other site 436717007791 Lysine efflux permease [General function prediction only]; Region: COG1279 436717007792 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 436717007793 Cd(II)/Pb(II)-responsive transcriptional regulator; Region: CadR-PbrR; TIGR02047 436717007794 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 436717007795 DNA binding residues [nucleotide binding] 436717007796 Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988 436717007797 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 436717007798 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 436717007799 Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988 436717007800 Aminopeptidase P, N-terminal domain; Region: AMP_N; pfam05195 436717007801 proline aminopeptidase P II; Provisional; Region: PRK10879 436717007802 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 436717007803 active site 436717007804 Uncharacterized protein family (UPF0149); Region: UPF0149; pfam03695 436717007805 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 436717007806 Cell division protein ZapA; Region: ZapA; pfam05164 436717007807 serine hydroxymethyltransferase; Reviewed; Region: PRK13034 436717007808 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 436717007809 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 436717007810 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 436717007811 Found in ATP-dependent protease La (LON); Region: LON; smart00464 436717007812 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 436717007813 Walker A motif; other site 436717007814 ATP binding site [chemical binding]; other site 436717007815 Walker B motif; other site 436717007816 arginine finger; other site 436717007817 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 436717007818 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 436717007819 The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363 436717007820 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 436717007821 putative active site [active] 436717007822 metal binding site [ion binding]; metal-binding site 436717007823 META domain; Region: META; pfam03724 436717007824 META domain; Region: META; pfam03724 436717007825 Domain of unknown function (DUF4377); Region: DUF4377; pfam14302 436717007826 glutamate dehydrogenase; Provisional; Region: PRK09414 436717007827 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 436717007828 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 436717007829 NAD(P) binding site [chemical binding]; other site 436717007830 ferredoxin; Provisional; Region: PRK08764 436717007831 Putative Fe-S cluster; Region: FeS; cl17515 436717007832 4Fe-4S binding domain; Region: Fer4; pfam00037 436717007833 endonuclease III; Provisional; Region: PRK10702 436717007834 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 436717007835 minor groove reading motif; other site 436717007836 helix-hairpin-helix signature motif; other site 436717007837 substrate binding pocket [chemical binding]; other site 436717007838 active site 436717007839 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 436717007840 adenylate kinase; Reviewed; Region: adk; PRK00279 436717007841 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 436717007842 AMP-binding site [chemical binding]; other site 436717007843 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 436717007844 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399 436717007845 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 436717007846 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 436717007847 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 436717007848 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 436717007849 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 436717007850 S-adenosylmethionine binding site [chemical binding]; other site 436717007851 HupE / UreJ protein; Region: HupE_UreJ; pfam04955 436717007852 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 436717007853 G1 box; other site 436717007854 GTP/Mg2+ binding site [chemical binding]; other site 436717007855 G2 box; other site 436717007856 Switch I region; other site 436717007857 G3 box; other site 436717007858 Switch II region; other site 436717007859 G4 box; other site 436717007860 G5 box; other site 436717007861 Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830 436717007862 UreF; Region: UreF; pfam01730 436717007863 urease accessory protein UreE; Provisional; Region: ureE; PRK13261 436717007864 UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571 436717007865 dimer interface [polypeptide binding]; other site 436717007866 catalytic residues [active] 436717007867 urease subunit alpha; Reviewed; Region: ureC; PRK13207 436717007868 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 436717007869 subunit interactions [polypeptide binding]; other site 436717007870 active site 436717007871 flap region; other site 436717007872 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 436717007873 gamma-beta subunit interface [polypeptide binding]; other site 436717007874 alpha-beta subunit interface [polypeptide binding]; other site 436717007875 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 436717007876 alpha-gamma subunit interface [polypeptide binding]; other site 436717007877 beta-gamma subunit interface [polypeptide binding]; other site 436717007878 UreD urease accessory protein; Region: UreD; pfam01774 436717007879 NlpE N-terminal domain; Region: NlpE; pfam04170 436717007880 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 436717007881 tetramer interface [polypeptide binding]; other site 436717007882 active site 436717007883 Mg2+/Mn2+ binding site [ion binding]; other site 436717007884 isocitrate lyase; Region: PLN02892 436717007885 Transcriptional regulator [Transcription]; Region: LysR; COG0583 436717007886 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 436717007887 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 436717007888 substrate binding pocket [chemical binding]; other site 436717007889 dimerization interface [polypeptide binding]; other site 436717007890 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 436717007891 Domain of unknown function DUF21; Region: DUF21; pfam01595 436717007892 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 436717007893 Transporter associated domain; Region: CorC_HlyC; smart01091 436717007894 H+/citrate symporter [Energy production and conversion]; Region: CitM; COG2851 436717007895 Citrate transporter; Region: CitMHS; pfam03600 436717007896 Uncharacterized protein conserved in bacteria (DUF2239); Region: DUF2239; pfam09998 436717007897 sulfate adenylyltransferase subunit 1; Provisional; Region: cysN; PRK05124 436717007898 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 436717007899 CysD dimerization site [polypeptide binding]; other site 436717007900 G1 box; other site 436717007901 putative GEF interaction site [polypeptide binding]; other site 436717007902 GTP/Mg2+ binding site [chemical binding]; other site 436717007903 Switch I region; other site 436717007904 G2 box; other site 436717007905 G3 box; other site 436717007906 Switch II region; other site 436717007907 G4 box; other site 436717007908 G5 box; other site 436717007909 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 436717007910 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 436717007911 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 436717007912 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 436717007913 Active Sites [active] 436717007914 Capsule assembly protein Wzi; Region: Caps_assemb_Wzi; pfam14052 436717007915 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 436717007916 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 436717007917 dimer interface [polypeptide binding]; other site 436717007918 putative anticodon binding site; other site 436717007919 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 436717007920 motif 1; other site 436717007921 active site 436717007922 motif 2; other site 436717007923 motif 3; other site 436717007924 Uncharacterized protein family (UPF0227); Region: UPF0227; cl14886 436717007925 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 436717007926 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 436717007927 Rubredoxin [Energy production and conversion]; Region: COG1773 436717007928 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 436717007929 iron binding site [ion binding]; other site 436717007930 NADH:flavorubredoxin oxidoreductase; Provisional; Region: PRK04965 436717007931 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 436717007932 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 436717007933 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 436717007934 DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151 436717007935 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 436717007936 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 436717007937 dimerization interface [polypeptide binding]; other site 436717007938 Sporulation related domain; Region: SPOR; cl10051 436717007939 polyphosphate kinase; Provisional; Region: PRK05443 436717007940 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 436717007941 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 436717007942 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 436717007943 putative active site [active] 436717007944 catalytic site [active] 436717007945 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 436717007946 putative active site [active] 436717007947 putative domain interface [polypeptide binding]; other site 436717007948 catalytic site [active] 436717007949 monofunctional biosynthetic peptidoglycan transglycosylase; Provisional; Region: mtgA; PRK00056 436717007950 Transglycosylase; Region: Transgly; cl17702 436717007951 Rhomboid family; Region: Rhomboid; pfam01694 436717007952 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127 436717007953 FtsX-like permease family; Region: FtsX; pfam02687 436717007954 FtsX-like permease family; Region: FtsX; pfam02687 436717007955 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG4181 436717007956 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 436717007957 Walker A/P-loop; other site 436717007958 ATP binding site [chemical binding]; other site 436717007959 Q-loop/lid; other site 436717007960 ABC transporter signature motif; other site 436717007961 Walker B; other site 436717007962 D-loop; other site 436717007963 H-loop/switch region; other site 436717007964 Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822 436717007965 active site 436717007966 catalytic triad [active] 436717007967 oxyanion hole [active] 436717007968 switch loop; other site 436717007969 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378 436717007970 active site clefts [active] 436717007971 zinc binding site [ion binding]; other site 436717007972 dimer interface [polypeptide binding]; other site 436717007973 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 436717007974 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 436717007975 nucleophilic elbow; other site 436717007976 catalytic triad; other site 436717007977 outer membrane receptor FepA; Provisional; Region: PRK13524 436717007978 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 436717007979 N-terminal plug; other site 436717007980 ligand-binding site [chemical binding]; other site 436717007981 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 436717007982 IscR-regulated protein YhgI; Region: YhgI_GntY; TIGR03341 436717007983 Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694 436717007984 Rhomboid family; Region: Rhomboid; cl11446 436717007985 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 436717007986 Sulfatase; Region: Sulfatase; pfam00884 436717007987 Uncharacterized conserved protein [Function unknown]; Region: COG1262 436717007988 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 436717007989 D-Serine dehydratase is a pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of L- or D-serine to pyruvate and ammonia. D-serine dehydratase serves as a detoxifying enzyme in most E. coli strains where D-serine is a competitive...; Region: D-Ser-dehyd; cd06447 436717007990 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 436717007991 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 436717007992 catalytic residue [active] 436717007993 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 436717007994 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 436717007995 B12-dependent methionine synthase; Provisional; Region: metH; PRK09490 436717007996 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 436717007997 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 436717007998 substrate binding pocket [chemical binding]; other site 436717007999 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 436717008000 B12 binding site [chemical binding]; other site 436717008001 cobalt ligand [ion binding]; other site 436717008002 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 436717008003 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 436717008004 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 436717008005 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 436717008006 PYR/PP interface [polypeptide binding]; other site 436717008007 dimer interface [polypeptide binding]; other site 436717008008 TPP binding site [chemical binding]; other site 436717008009 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 436717008010 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 436717008011 TPP-binding site [chemical binding]; other site 436717008012 dimer interface [polypeptide binding]; other site 436717008013 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 436717008014 D-galactonate transporter; Region: 2A0114; TIGR00893 436717008015 putative substrate translocation pore; other site 436717008016 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 436717008017 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 436717008018 NAD(P) binding site [chemical binding]; other site 436717008019 active site 436717008020 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 436717008021 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 436717008022 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 436717008023 dimerization interface [polypeptide binding]; other site 436717008024 substrate binding pocket [chemical binding]; other site 436717008025 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 436717008026 active site 436717008027 catalytic residues [active] 436717008028 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 436717008029 putative substrate translocation pore; other site 436717008030 Major Facilitator Superfamily; Region: MFS_1; pfam07690 436717008031 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 436717008032 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 436717008033 glutaminase; Provisional; Region: PRK00971 436717008034 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 436717008035 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 436717008036 active site 436717008037 catalytic residues [active] 436717008038 metal binding site [ion binding]; metal-binding site 436717008039 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 436717008040 metabolite-proton symporter; Region: 2A0106; TIGR00883 436717008041 putative substrate translocation pore; other site 436717008042 hypothetical protein; Provisional; Region: PRK07064 436717008043 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 436717008044 PYR/PP interface [polypeptide binding]; other site 436717008045 dimer interface [polypeptide binding]; other site 436717008046 TPP binding site [chemical binding]; other site 436717008047 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 436717008048 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 436717008049 TPP-binding site [chemical binding]; other site 436717008050 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 436717008051 Uncharacterized Candidatus pelagibacter aldehyde dehydrogenase, DhaS-like; Region: ALDH_DhaS; cd07114 436717008052 NAD(P) binding site [chemical binding]; other site 436717008053 catalytic residues [active] 436717008054 L-aspartate dehydrogenase; Provisional; Region: PRK13303 436717008055 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 436717008056 Domain of unknown function DUF108; Region: DUF108; pfam01958 436717008057 short chain dehydrogenase; Provisional; Region: PRK07062 436717008058 putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344 436717008059 putative NAD(P) binding site [chemical binding]; other site 436717008060 putative active site [active] 436717008061 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 436717008062 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 436717008063 Cupin domain; Region: Cupin_2; pfam07883 436717008064 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 436717008065 D-galactonate transporter; Region: 2A0114; TIGR00893 436717008066 putative substrate translocation pore; other site 436717008067 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 436717008068 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 436717008069 2,3-dihydroxybiphenyl 1,2-dioxygenase; Region: 23dbph12diox; TIGR03213 436717008070 C-terminal domain of Burkholderia sp. NF100 MhqB and similar proteins; MhqB is a type I extradiol dioxygenase involved in the catabolism of methylhydroquinone, an intermediate in the degradation of fenitrothion; Region: MhqB_like_C; cd08360 436717008071 putative active site [active] 436717008072 putative metal binding site [ion binding]; other site 436717008073 short chain dehydrogenase; Provisional; Region: PRK12939 436717008074 classical (c) SDRs; Region: SDR_c; cd05233 436717008075 NAD(P) binding site [chemical binding]; other site 436717008076 active site 436717008077 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 436717008078 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 436717008079 [2Fe-2S] cluster binding site [ion binding]; other site 436717008080 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 436717008081 hydrophobic ligand binding site; other site 436717008082 Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528 436717008083 [2Fe-2S] cluster binding site [ion binding]; other site 436717008084 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 436717008085 Transcriptional regulator [Transcription]; Region: IclR; COG1414 436717008086 Bacterial transcriptional regulator; Region: IclR; pfam01614 436717008087 Nicotinamide mononucleotide transporter; Region: NMN_transporter; pfam04973 436717008088 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 436717008089 EamA-like transporter family; Region: EamA; pfam00892 436717008090 enoyl-CoA hydratase; Provisional; Region: PRK06563 436717008091 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 436717008092 substrate binding site [chemical binding]; other site 436717008093 oxyanion hole (OAH) forming residues; other site 436717008094 trimer interface [polypeptide binding]; other site 436717008095 Predicted alpha/beta hydrolase [General function prediction only]; Region: COG4757 436717008096 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 436717008097 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 436717008098 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 436717008099 PgaD-like protein; Region: PgaD; pfam13994 436717008100 N-glycosyltransferase; Provisional; Region: PRK11204 436717008101 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 436717008102 DXD motif; other site 436717008103 poly-beta-1,6-N-acetyl-D-glucosamine N-deacetylase PgaB; Region: deacetyl_PgaB; TIGR03938 436717008104 N-terminal putative catalytic polysaccharide deacetylase domain of bacterial poly-beta-1,6-N-acetyl-D-glucosamine N-deacetylase PgaB, and similar proteins; Region: CE4_PgaB_5s; cd10964 436717008105 putative active site [active] 436717008106 putative metal binding site [ion binding]; other site 436717008107 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 436717008108 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 436717008109 YaeQ protein; Region: YaeQ; pfam07152 436717008110 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 436717008111 C4-dicarboxylate transporter DctA; Reviewed; Region: PRK13027 436717008112 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 436717008113 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 436717008114 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; cl08458 436717008115 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 436717008116 Multiple antibiotic transporter [Intracellular trafficking and secretion]; Region: MarC; COG2095 436717008117 choline transport protein BetT; Provisional; Region: PRK09928 436717008118 BCCT family transporter; Region: BCCT; pfam02028 436717008119 transcriptional regulator BetI; Validated; Region: PRK00767 436717008120 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 436717008121 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 436717008122 betaine aldehyde dehydrogenase; Provisional; Region: PRK13252 436717008123 NAD+-dependent 4-trimethylaminobutyraldehyde dehydrogenase, ALDH family 9A1; Region: ALDH_F9_TMBADH; cd07090 436717008124 tetrameric interface [polypeptide binding]; other site 436717008125 NAD binding site [chemical binding]; other site 436717008126 catalytic residues [active] 436717008127 choline dehydrogenase; Validated; Region: PRK02106 436717008128 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 436717008129 malate:quinone oxidoreductase; Validated; Region: PRK05257 436717008130 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 436717008131 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 436717008132 Homocysteine/selenocysteine methylase (S-methylmethionine-dependent) [Amino acid transport and metabolism]; Region: MHT1; COG2040 436717008133 arginine-ornithine antiporter; Region: arg_ornith_anti; TIGR03810 436717008134 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 436717008135 PGAP1-like protein; Region: PGAP1; pfam07819 436717008136 Protein of unknown function (DUF1275); Region: DUF1275; pfam06912 436717008137 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2832 436717008138 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cd00232 436717008139 heme binding pocket [chemical binding]; other site 436717008140 heme ligand [chemical binding]; other site 436717008141 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 436717008142 TPR repeat; Region: TPR_11; pfam13414 436717008143 Protein of unknown function (DUF560); Region: DUF560; pfam04575 436717008144 Secretin and TonB N terminus short domain; Region: STN; pfam07660 436717008145 TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786 436717008146 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 436717008147 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 436717008148 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 436717008149 FecR protein; Region: FecR; pfam04773 436717008150 RNA polymerase sigma factor; Reviewed; Region: PRK12523 436717008151 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 436717008152 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 436717008153 DNA binding residues [nucleotide binding] 436717008154 Transcriptional regulator [Transcription]; Region: LysR; COG0583 436717008155 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 436717008156 The C-teminal substrate binding domain of LysR-like nitrogen assimilation control (NAC) protein, contains the type 2 periplasmic binding fold; Region: PBP2_Nac; cd08433 436717008157 putative dimerization interface [polypeptide binding]; other site 436717008158 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 436717008159 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 436717008160 inhibitor site; inhibition site 436717008161 active site 436717008162 dimer interface [polypeptide binding]; other site 436717008163 catalytic residue [active] 436717008164 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 436717008165 benzoate transport; Region: 2A0115; TIGR00895 436717008166 putative substrate translocation pore; other site 436717008167 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 436717008168 outer membrane porin, OprD family; Region: OprD; pfam03573 436717008169 Mrr N-terminal domain; Region: Mrr_N; pfam14338 436717008170 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 436717008171 active site 436717008172 Domain of unknown function DUF87; Region: DUF87; pfam01935 436717008173 HerA helicase [Replication, recombination, and repair]; Region: COG0433 436717008174 D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; cl17344 436717008175 Uncharacterized ACR, COG2135; Region: DUF159; pfam02586 436717008176 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 436717008177 Catalytic site [active] 436717008178 DNA polymerase V subunit UmuC; Reviewed; Region: umuC; PRK03609 436717008179 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 436717008180 active site 436717008181 DNA binding site [nucleotide binding] 436717008182 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 436717008183 Glycosyl hydrolase 108; Region: Glyco_hydro_108; pfam05838 436717008184 Predicted Peptidoglycan domain; Region: PG_binding_3; pfam09374 436717008185 Lysis protein S; Region: Lysis_S; pfam04971 436717008186 Putative phage tail protein; Region: Phage-tail_3; pfam13550 436717008187 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cl00065 436717008188 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 436717008189 NlpC/P60 family; Region: NLPC_P60; cl17555 436717008190 Uncharacterized conserved protein (DUF2163); Region: DUF2163; pfam09931 436717008191 Phage conserved hypothetical protein BR0599; Region: Phage_BR0599; pfam09356 436717008192 Conserved hypothetical protein 2217 (DUF2460); Region: DUF2460; pfam09343 436717008193 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 436717008194 1-deoxy-D-xylulose 5-phosphate reductoisomerase [Lipid metabolism]; Region: Dxr; COG0743 436717008195 Protein of unknown function (DUF4054); Region: DUF4054; pfam13262 436717008196 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4834 436717008197 Uncharacterized protein conserved in bacteria (DUF2184); Region: DUF2184; pfam09950 436717008198 Uncharacterized protein conserved in bacteria (DUF2213); Region: DUF2213; pfam09979 436717008199 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3566 436717008200 Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072 436717008201 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3567 436717008202 phage-related protein, HI1409 family; Region: phge_rel_HI1409; TIGR01555 436717008203 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5410 436717008204 Terminase-like family; Region: Terminase_6; pfam03237 436717008205 Phage-related terminase [General function prediction only]; Region: COG5362; cl02216 436717008206 Uncharacterized conserved protein (DUF2280); Region: DUF2280; pfam10045 436717008207 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dam; COG0338 436717008208 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 436717008209 putative active site [active] 436717008210 Helix-turn-helix domain; Region: HTH_36; pfam13730 436717008211 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 436717008212 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 436717008213 cofactor binding site; other site 436717008214 DNA binding site [nucleotide binding] 436717008215 substrate interaction site [chemical binding]; other site 436717008216 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 436717008217 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 436717008218 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 436717008219 non-specific DNA binding site [nucleotide binding]; other site 436717008220 salt bridge; other site 436717008221 sequence-specific DNA binding site [nucleotide binding]; other site 436717008222 Predicted transcriptional regulator [Transcription]; Region: COG2932 436717008223 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 436717008224 Catalytic site [active] 436717008225 AAA domain; Region: AAA_24; pfam13479 436717008226 phage nucleotide-binding protein; Region: phage_P_loop; TIGR01618 436717008227 This domain directs oriented DNA translocation and forms a winged helix structure; Region: Ftsk_gamma; smart00843 436717008228 bifunctional UDP-glucuronic acid decarboxylase/UDP-4-amino-4-deoxy-L-arabinose formyltransferase; Validated; Region: PRK08125 436717008229 integrase; Provisional; Region: PRK09692 436717008230 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 436717008231 active site 436717008232 Int/Topo IB signature motif; other site 436717008233 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 436717008234 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 436717008235 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 436717008236 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 436717008237 putative substrate translocation pore; other site 436717008238 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 436717008239 efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998 436717008240 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 436717008241 HlyD family secretion protein; Region: HlyD_3; pfam13437 436717008242 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 436717008243 CoenzymeA binding site [chemical binding]; other site 436717008244 subunit interaction site [polypeptide binding]; other site 436717008245 PHB binding site; other site 436717008246 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823 436717008247 dimer interface [polypeptide binding]; other site 436717008248 allosteric magnesium binding site [ion binding]; other site 436717008249 active site 436717008250 aspartate-rich active site metal binding site; other site 436717008251 Schiff base residues; other site 436717008252 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 436717008253 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 436717008254 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 436717008255 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 436717008256 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 436717008257 NAD(P) binding site [chemical binding]; other site 436717008258 active site 436717008259 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 436717008260 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 436717008261 OsmC-like protein; Region: OsmC; cl00767 436717008262 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 436717008263 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 436717008264 active site 436717008265 metal binding site [ion binding]; metal-binding site 436717008266 DNA binding site [nucleotide binding] 436717008267 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 436717008268 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 436717008269 AAA domain; Region: AAA_23; pfam13476 436717008270 Walker A/P-loop; other site 436717008271 ATP binding site [chemical binding]; other site 436717008272 Q-loop/lid; other site 436717008273 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 436717008274 ABC transporter signature motif; other site 436717008275 Walker B; other site 436717008276 D-loop; other site 436717008277 H-loop/switch region; other site 436717008278 Bacitracin resistance protein BacA; Region: BacA; pfam02673 436717008279 Pyridoxal 5-phosphate (PLP)-binding TIM barrel domain of Type III PLP-Dependent Enzymes, Yggs-like proteins; Region: PLPDE_III_Yggs_like; cd06824 436717008280 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 436717008281 catalytic residue [active] 436717008282 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 436717008283 Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131 436717008284 Walker A motif; other site 436717008285 ATP binding site [chemical binding]; other site 436717008286 Walker B motif; other site 436717008287 Tfp pilus assembly protein, ATPase PilU [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilU; COG5008 436717008288 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 436717008289 Walker A motif; other site 436717008290 ATP binding site [chemical binding]; other site 436717008291 Walker B motif; other site 436717008292 ferric uptake regulator; Provisional; Region: fur; PRK09462 436717008293 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 436717008294 metal binding site 2 [ion binding]; metal-binding site 436717008295 putative DNA binding helix; other site 436717008296 metal binding site 1 [ion binding]; metal-binding site 436717008297 dimer interface [polypeptide binding]; other site 436717008298 structural Zn2+ binding site [ion binding]; other site 436717008299 Outer membrane lipoprotein OmlA (small protein A) [Cell envelope biogenesis, outer membrane]; Region: OlmA; COG2913 436717008300 SmpA / OmlA family; Region: SmpA_OmlA; pfam04355 436717008301 RnfH family Ubiquitin; Region: Ub-RnfH; cl17382 436717008302 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 436717008303 Hemerythrin; Region: Hemerythrin; cd12107 436717008304 Fe binding site [ion binding]; other site 436717008305 Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121 436717008306 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 436717008307 putative active site [active] 436717008308 putative dimer interface [polypeptide binding]; other site 436717008309 Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; pfam13444 436717008310 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 436717008311 feedback inhibition sensing region; other site 436717008312 homohexameric interface [polypeptide binding]; other site 436717008313 nucleotide binding site [chemical binding]; other site 436717008314 N-acetyl-L-glutamate binding site [chemical binding]; other site 436717008315 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 436717008316 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 436717008317 active site 436717008318 substrate binding site [chemical binding]; other site 436717008319 metal binding site [ion binding]; metal-binding site 436717008320 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 436717008321 trimer interface [polypeptide binding]; other site 436717008322 active site 436717008323 ATP-dependent DNA helicase Rep; Region: rep; TIGR01074 436717008324 Part of AAA domain; Region: AAA_19; pfam13245 436717008325 Family description; Region: UvrD_C_2; pfam13538 436717008326 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 436717008327 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 436717008328 ligand binding site [chemical binding]; other site 436717008329 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 436717008330 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; Region: LPLAT_LCLAT1-like; cd07990 436717008331 putative acyl-acceptor binding pocket; other site 436717008332 Septum formation inhibitor [Cell division and chromosome partitioning]; Region: MinC; COG0850 436717008333 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 436717008334 Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894 436717008335 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 436717008336 Switch I; other site 436717008337 Switch II; other site 436717008338 Septum formation topological specificity factor MinE; Region: MinE; pfam03776 436717008339 threonine efflux system; Provisional; Region: PRK10229 436717008340 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 436717008341 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 436717008342 This domain directs oriented DNA translocation and forms a winged helix structure; Region: Ftsk_gamma; smart00843 436717008343 thioredoxin reductase; Provisional; Region: PRK10262 436717008344 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 436717008345 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 436717008346 leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301 436717008347 arginyl-tRNA-protein transferase; Provisional; Region: PRK01305 436717008348 Arginine-tRNA-protein transferase, N terminus; Region: ATE_N; pfam04376 436717008349 Arginine-tRNA-protein transferase, C terminus; Region: ATE_C; pfam04377 436717008350 ribosomal-protein-alanine N-acetyltransferase; Provisional; Region: rimI; PRK09491 436717008351 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 436717008352 Coenzyme A binding pocket [chemical binding]; other site 436717008353 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687 436717008354 Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118 436717008355 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687 436717008356 Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118 436717008357 elongation factor Tu; Reviewed; Region: PRK00049 436717008358 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 436717008359 G1 box; other site 436717008360 GEF interaction site [polypeptide binding]; other site 436717008361 GTP/Mg2+ binding site [chemical binding]; other site 436717008362 Switch I region; other site 436717008363 G2 box; other site 436717008364 G3 box; other site 436717008365 Switch II region; other site 436717008366 G4 box; other site 436717008367 G5 box; other site 436717008368 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 436717008369 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 436717008370 Antibiotic Binding Site [chemical binding]; other site 436717008371 elongation factor G; Reviewed; Region: PRK00007 436717008372 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 436717008373 G1 box; other site 436717008374 putative GEF interaction site [polypeptide binding]; other site 436717008375 GTP/Mg2+ binding site [chemical binding]; other site 436717008376 Switch I region; other site 436717008377 G2 box; other site 436717008378 G3 box; other site 436717008379 Switch II region; other site 436717008380 G4 box; other site 436717008381 G5 box; other site 436717008382 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 436717008383 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 436717008384 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 436717008385 30S ribosomal protein S7; Validated; Region: PRK05302 436717008386 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 436717008387 S17 interaction site [polypeptide binding]; other site 436717008388 S8 interaction site; other site 436717008389 16S rRNA interaction site [nucleotide binding]; other site 436717008390 streptomycin interaction site [chemical binding]; other site 436717008391 23S rRNA interaction site [nucleotide binding]; other site 436717008392 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 436717008393 EcsC protein family; Region: EcsC; pfam12787 436717008394 3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK07967 436717008395 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 436717008396 dimer interface [polypeptide binding]; other site 436717008397 active site 436717008398 Uncharacterized protein family (UPF0093); Region: UPF0093; pfam03653 436717008399 NAD synthetase; Provisional; Region: PRK13981 436717008400 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 436717008401 multimer interface [polypeptide binding]; other site 436717008402 active site 436717008403 catalytic triad [active] 436717008404 protein interface 1 [polypeptide binding]; other site 436717008405 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 436717008406 homodimer interface [polypeptide binding]; other site 436717008407 NAD binding pocket [chemical binding]; other site 436717008408 ATP binding pocket [chemical binding]; other site 436717008409 Mg binding site [ion binding]; other site 436717008410 active-site loop [active] 436717008411 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 436717008412 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 436717008413 FMN-binding pocket [chemical binding]; other site 436717008414 flavin binding motif; other site 436717008415 phosphate binding motif [ion binding]; other site 436717008416 beta-alpha-beta structure motif; other site 436717008417 NAD binding pocket [chemical binding]; other site 436717008418 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 436717008419 catalytic loop [active] 436717008420 iron binding site [ion binding]; other site 436717008421 succinic semialdehyde dehydrogenase; Region: PLN02278 436717008422 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 436717008423 tetramerization interface [polypeptide binding]; other site 436717008424 NAD(P) binding site [chemical binding]; other site 436717008425 catalytic residues [active] 436717008426 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 436717008427 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 436717008428 [2Fe-2S] cluster binding site [ion binding]; other site 436717008429 C-terminal catalytic domain of the oxygenase alpha subunit of an uncharacterized subgroup of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C_2; cd08886 436717008430 putative alpha subunit interface [polypeptide binding]; other site 436717008431 putative active site [active] 436717008432 putative substrate binding site [chemical binding]; other site 436717008433 Fe binding site [ion binding]; other site 436717008434 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 436717008435 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 436717008436 substrate binding pocket [chemical binding]; other site 436717008437 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 436717008438 putative transporter; Provisional; Region: PRK09950 436717008439 Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473 436717008440 tartrate dehydrogenase; Region: TTC; TIGR02089 436717008441 transcriptional activator TtdR; Provisional; Region: PRK09801 436717008442 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 436717008443 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_9; cd08479 436717008444 putative effector binding pocket; other site 436717008445 putative dimerization interface [polypeptide binding]; other site 436717008446 Phosphate-selective porin O and P; Region: Porin_O_P; pfam07396 436717008447 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 436717008448 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 436717008449 active site 436717008450 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 436717008451 SmpB-tmRNA interface; other site 436717008452 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 436717008453 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 436717008454 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 436717008455 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 436717008456 23S rRNA pseudouridine synthase D; Provisional; Region: rluD; PRK11180 436717008457 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 436717008458 RNA binding surface [nucleotide binding]; other site 436717008459 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 436717008460 active site 436717008461 Outer membrane lipoprotein; Region: YfiO; pfam13525 436717008462 DNA primase, catalytic core; Region: dnaG; TIGR01391 436717008463 CHC2 zinc finger; Region: zf-CHC2; pfam01807 436717008464 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 436717008465 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 436717008466 active site 436717008467 metal binding site [ion binding]; metal-binding site 436717008468 interdomain interaction site; other site 436717008469 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 436717008470 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 436717008471 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 436717008472 tRNA; other site 436717008473 putative tRNA binding site [nucleotide binding]; other site 436717008474 putative NADP binding site [chemical binding]; other site 436717008475 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 436717008476 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 436717008477 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 436717008478 binding surface 436717008479 TPR motif; other site 436717008480 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 436717008481 binding surface 436717008482 TPR motif; other site 436717008483 outer membrane lipoprotein LolB; Provisional; Region: lolB; PRK00022 436717008484 Outer membrane lipoprotein LolB; Region: LolB; pfam03550 436717008485 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00343 436717008486 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 436717008487 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 436717008488 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 436717008489 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 436717008490 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 436717008491 active site 436717008492 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 436717008493 5S rRNA interface [nucleotide binding]; other site 436717008494 CTC domain interface [polypeptide binding]; other site 436717008495 L16 interface [polypeptide binding]; other site 436717008496 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 436717008497 putative active site [active] 436717008498 catalytic residue [active] 436717008499 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 436717008500 tetramerization interface [polypeptide binding]; other site 436717008501 active site 436717008502 GDYXXLXY protein; Region: GDYXXLXY; pfam14345 436717008503 Predicted membrane protein (DUF2157); Region: DUF2157; cl10480 436717008504 Domain of unknown function (DUF4401); Region: DUF4401; pfam14351 436717008505 3,4-dihydroxy-2-butanone 4-phosphate synthase; Provisional; Region: ribB; PRK03353 436717008506 3,4-dihydroxy-2-butanone 4-phosphate synthase [Coenzyme metabolism]; Region: RibB; COG0108 436717008507 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 436717008508 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 436717008509 motif II; other site 436717008510 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 436717008511 dimer interface [polypeptide binding]; other site 436717008512 substrate binding site [chemical binding]; other site 436717008513 ATP binding site [chemical binding]; other site 436717008514 LysM domain/BON superfamily protein; Provisional; Region: PRK11198 436717008515 BON domain; Region: BON; pfam04972 436717008516 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 436717008517 acyl carrier protein; Provisional; Region: acpP; PRK00982 436717008518 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 436717008519 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 436717008520 NAD(P) binding site [chemical binding]; other site 436717008521 homotetramer interface [polypeptide binding]; other site 436717008522 homodimer interface [polypeptide binding]; other site 436717008523 active site 436717008524 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 436717008525 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 436717008526 50S ribosomal protein L32; Validated; Region: rpmF; PRK01110 436717008527 Uncharacterized ACR, COG1399; Region: DUF177; pfam02620 436717008528 Protein of unknown function, DUF462; Region: DUF462; pfam04315 436717008529 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 436717008530 ScpA/B protein; Region: ScpA_ScpB; cl00598 436717008531 Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079 436717008532 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 436717008533 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 436717008534 RNA binding surface [nucleotide binding]; other site 436717008535 Pseudouridine synthase, Escherichia coli RluB like; Region: PseudoU_synth_RluB; cd02556 436717008536 probable active site [active] 436717008537 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 436717008538 AAA domain; Region: AAA_26; pfam13500 436717008539 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 436717008540 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 436717008541 S-adenosylmethionine binding site [chemical binding]; other site 436717008542 8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958 436717008543 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 436717008544 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 436717008545 catalytic residue [active] 436717008546 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 436717008547 adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK06173 436717008548 inhibitor-cofactor binding pocket; inhibition site 436717008549 pyridoxal 5'-phosphate binding site [chemical binding]; other site 436717008550 catalytic residue [active] 436717008551 pimelyl-[acyl-carrier protein] methyl ester esterase; Region: bioH; TIGR01738 436717008552 Trehalose-6-phosphatase [Carbohydrate transport and metabolism]; Region: OtsB; COG1877 436717008553 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 436717008554 active site 436717008555 motif I; other site 436717008556 motif II; other site 436717008557 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 436717008558 alpha,alpha-trehalose-phosphate synthase [UDP-forming]; Region: trehalose_OtsA; TIGR02400 436717008559 active site 436717008560 homotetramer interface [polypeptide binding]; other site 436717008561 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 436717008562 Major Facilitator Superfamily; Region: MFS_1; pfam07690 436717008563 putative substrate translocation pore; other site 436717008564 Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193 436717008565 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 436717008566 heme binding site [chemical binding]; other site 436717008567 ferroxidase pore; other site 436717008568 ferroxidase diiron center [ion binding]; other site 436717008569 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 436717008570 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 436717008571 nucleotide binding pocket [chemical binding]; other site 436717008572 K-X-D-G motif; other site 436717008573 catalytic site [active] 436717008574 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 436717008575 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 436717008576 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 436717008577 Dimer interface [polypeptide binding]; other site 436717008578 BRCT sequence motif; other site 436717008579 ZipA, C-terminal FtsZ-binding domain; Region: ZipA_C; pfam04354 436717008580 FtsZ protein binding site [polypeptide binding]; other site 436717008581 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 436717008582 AAA domain; Region: AAA_23; pfam13476 436717008583 Walker A/P-loop; other site 436717008584 ATP binding site [chemical binding]; other site 436717008585 Q-loop/lid; other site 436717008586 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 436717008587 ABC transporter signature motif; other site 436717008588 Walker B; other site 436717008589 D-loop; other site 436717008590 H-loop/switch region; other site 436717008591 Transcriptional regulators [Transcription]; Region: GntR; COG1802 436717008592 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 436717008593 DNA-binding site [nucleotide binding]; DNA binding site 436717008594 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 436717008595 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 436717008596 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 436717008597 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 436717008598 pantothenate kinase; Reviewed; Region: PRK13322 436717008599 signal recognition particle protein; Provisional; Region: PRK10867 436717008600 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 436717008601 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 436717008602 GTP binding site [chemical binding]; other site 436717008603 Signal peptide binding domain; Region: SRP_SPB; pfam02978 436717008604 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 436717008605 tRNA-dihydrouridine synthase C; Provisional; Region: PRK10550 436717008606 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 436717008607 FMN binding site [chemical binding]; other site 436717008608 active site 436717008609 catalytic residues [active] 436717008610 substrate binding site [chemical binding]; other site 436717008611 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 436717008612 trimer interface [polypeptide binding]; other site 436717008613 active site 436717008614 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 436717008615 Uncharacterized protein conserved in bacteria (DUF2062); Region: DUF2062; pfam09835 436717008616 Phosphorylase superfamily; Region: PNP_UDP_1; pfam01048 436717008617 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 436717008618 methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133 436717008619 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 436717008620 active site 436717008621 HIGH motif; other site 436717008622 KMSKS motif; other site 436717008623 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 436717008624 tRNA binding surface [nucleotide binding]; other site 436717008625 anticodon binding site; other site 436717008626 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 436717008627 dimer interface [polypeptide binding]; other site 436717008628 putative tRNA-binding site [nucleotide binding]; other site 436717008629 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 436717008630 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 436717008631 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 436717008632 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 436717008633 Major Facilitator Superfamily; Region: MFS_1; pfam07690 436717008634 putative substrate translocation pore; other site 436717008635 efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998 436717008636 HlyD family secretion protein; Region: HlyD_3; pfam13437 436717008637 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 436717008638 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 436717008639 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 436717008640 catalytic residue [active] 436717008641 HI0933-like protein; Region: HI0933_like; pfam03486 436717008642 Conserved TM helix; Region: TM_helix; pfam05552 436717008643 Conserved TM helix; Region: TM_helix; pfam05552 436717008644 Conserved TM helix; Region: TM_helix; pfam05552 436717008645 Conserved TM helix; Region: TM_helix; pfam05552 436717008646 ferredoxin-NADP reductase; Provisional; Region: PRK10926 436717008647 Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195 436717008648 FAD binding pocket [chemical binding]; other site 436717008649 FAD binding motif [chemical binding]; other site 436717008650 phosphate binding motif [ion binding]; other site 436717008651 beta-alpha-beta structure motif; other site 436717008652 NAD binding pocket [chemical binding]; other site 436717008653 putative DNA-binding transcriptional regulator; Provisional; Region: PRK10837 436717008654 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 436717008655 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 436717008656 putative dimerization interface [polypeptide binding]; other site 436717008657 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 436717008658 DNA-binding site [nucleotide binding]; DNA binding site 436717008659 RNA-binding motif; other site 436717008660 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 436717008661 active site 436717008662 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 436717008663 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 436717008664 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 436717008665 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 436717008666 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 436717008667 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 436717008668 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 436717008669 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 436717008670 NADH:ubiquinone oxidoreductase subunit 6 (chain J) [Energy production and conversion]; Region: NuoJ; COG0839 436717008671 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 436717008672 NADH-quinone oxidoreductase, chain I; Region: NuoI; TIGR01971 436717008673 4Fe-4S binding domain; Region: Fer4; pfam00037 436717008674 4Fe-4S binding domain; Region: Fer4; pfam00037 436717008675 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 436717008676 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 436717008677 NADH dehydrogenase subunit G; Validated; Region: PRK08166 436717008678 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 436717008679 catalytic loop [active] 436717008680 iron binding site [ion binding]; other site 436717008681 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 436717008682 MopB_NDH-1_NuoG2-N7: The second domain of the NuoG subunit (with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex in the respiratory...; Region: MopB_NDH-1_NuoG2-N7; cd02771 436717008683 [4Fe-4S] binding site [ion binding]; other site 436717008684 MopB_CT_NDH-1_NuoG2-N7: C-terminal region of the NuoG-like subunit (of the variant with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex...; Region: MopB_CT_NDH-1_NuoG2-N7; cd02788 436717008685 NADH dehydrogenase I subunit F; Provisional; Region: PRK11278 436717008686 SLBB domain; Region: SLBB; pfam10531 436717008687 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928 436717008688 NADH dehydrogenase subunit E; Validated; Region: PRK07539 436717008689 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 436717008690 putative dimer interface [polypeptide binding]; other site 436717008691 [2Fe-2S] cluster binding site [ion binding]; other site 436717008692 bifunctional NADH:ubiquinone oxidoreductase subunit C/D; Provisional; Region: PRK11742 436717008693 NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961 436717008694 NADH dehydrogenase subunit D; Validated; Region: PRK06075 436717008695 NADH dehydrogenase subunit B; Validated; Region: PRK06411 436717008696 NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602 436717008697 MASE1; Region: MASE1; cl17823 436717008698 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 436717008699 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 436717008700 metal binding site [ion binding]; metal-binding site 436717008701 active site 436717008702 I-site; other site 436717008703 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 436717008704 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 436717008705 dimerization interface [polypeptide binding]; other site 436717008706 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 436717008707 dimer interface [polypeptide binding]; other site 436717008708 phosphorylation site [posttranslational modification] 436717008709 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 436717008710 ATP binding site [chemical binding]; other site 436717008711 Mg2+ binding site [ion binding]; other site 436717008712 G-X-G motif; other site 436717008713 DNA-binding transcriptional regulator RstA; Provisional; Region: PRK10701 436717008714 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 436717008715 active site 436717008716 phosphorylation site [posttranslational modification] 436717008717 intermolecular recognition site; other site 436717008718 dimerization interface [polypeptide binding]; other site 436717008719 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 436717008720 DNA binding site [nucleotide binding] 436717008721 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07207 436717008722 ATP cone domain; Region: ATP-cone; pfam03477 436717008723 Class I ribonucleotide reductase; Region: RNR_I; cd01679 436717008724 active site 436717008725 dimer interface [polypeptide binding]; other site 436717008726 catalytic residues [active] 436717008727 effector binding site; other site 436717008728 R2 peptide binding site; other site 436717008729 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 436717008730 dimer interface [polypeptide binding]; other site 436717008731 putative radical transfer pathway; other site 436717008732 diiron center [ion binding]; other site 436717008733 tyrosyl radical; other site 436717008734 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 436717008735 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 436717008736 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 436717008737 pyridoxal 5'-phosphate binding site [chemical binding]; other site 436717008738 homodimer interface [polypeptide binding]; other site 436717008739 catalytic residue [active] 436717008740 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454 436717008741 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 436717008742 Predicted ATPase [General function prediction only]; Region: COG1485 436717008743 chromosome replication initiation inhibitor protein; Validated; Region: PRK03635 436717008744 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 436717008745 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 436717008746 dimerization interface [polypeptide binding]; other site 436717008747 hypothetical protein; Provisional; Region: PRK10281 436717008748 VirE N-terminal domain; Region: VirE_N; pfam08800 436717008749 Transcriptional regulator [Transcription]; Region: LysR; COG0583 436717008750 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 436717008751 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 436717008752 dimerization interface [polypeptide binding]; other site 436717008753 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 436717008754 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 436717008755 Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; cl01733 436717008756 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 436717008757 Sel1-like repeats; Region: SEL1; smart00671 436717008758 Sel1-like repeats; Region: SEL1; smart00671 436717008759 Sel1-like repeats; Region: SEL1; smart00671 436717008760 Sel1-like repeats; Region: SEL1; smart00671 436717008761 Sel1-like repeats; Region: SEL1; smart00671 436717008762 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 436717008763 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 436717008764 Flavin Reductases; Region: FlaRed; cl00801 436717008765 methionine synthase; Provisional; Region: PRK01207 436717008766 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 436717008767 substrate binding site [chemical binding]; other site 436717008768 THF binding site; other site 436717008769 zinc-binding site [ion binding]; other site 436717008770 Domain of unknown function (DUF1852); Region: DUF1852; pfam08908 436717008771 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 436717008772 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 436717008773 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 436717008774 dimerization interface [polypeptide binding]; other site 436717008775 LysE type translocator; Region: LysE; cl00565 436717008776 Fatty acid desaturase; Region: FA_desaturase; pfam00487 436717008777 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 436717008778 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 436717008779 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 436717008780 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 436717008781 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like6; cd05664 436717008782 metal binding site [ion binding]; metal-binding site 436717008783 putative dimer interface [polypeptide binding]; other site 436717008784 Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; cl17479 436717008785 Transcriptional regulator [Transcription]; Region: LysR; COG0583 436717008786 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 436717008787 The C-teminal substrate binding domain of LysR-like nitrogen assimilation control (NAC) protein, contains the type 2 periplasmic binding fold; Region: PBP2_Nac; cd08433 436717008788 putative dimerization interface [polypeptide binding]; other site 436717008789 citrate-proton symporter; Provisional; Region: PRK15075 436717008790 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 436717008791 putative substrate translocation pore; other site 436717008792 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 436717008793 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 436717008794 nitrogen assimilation transcriptional regulator; Provisional; Region: PRK11233 436717008795 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 436717008796 The C-teminal substrate binding domain of LysR-like nitrogen assimilation control (NAC) protein, contains the type 2 periplasmic binding fold; Region: PBP2_Nac; cd08433 436717008797 putative dimerization interface [polypeptide binding]; other site 436717008798 tricarballylate dehydrogenase; Validated; Region: PRK08274 436717008799 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 436717008800 tricarballylate utilization protein B; Provisional; Region: PRK15033 436717008801 HPP family; Region: HPP; pfam04982 436717008802 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 436717008803 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 436717008804 Glyoxalase-like domain; Region: Glyoxalase_3; pfam13468 436717008805 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 436717008806 nitrobindin heme-binding domain; Region: nitrobindin; cl10502 436717008807 CoA-transferase family III; Region: CoA_transf_3; pfam02515 436717008808 benzoate transport; Region: 2A0115; TIGR00895 436717008809 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 436717008810 putative substrate translocation pore; other site 436717008811 Glutaryl-CoA dehydrogenase; Region: GCD; cd01151 436717008812 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 436717008813 FAD binding site [chemical binding]; other site 436717008814 substrate binding pocket [chemical binding]; other site 436717008815 catalytic base [active] 436717008816 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 436717008817 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 436717008818 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 436717008819 dimerization interface [polypeptide binding]; other site 436717008820 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 436717008821 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH8; cd08262 436717008822 putative NAD(P) binding site [chemical binding]; other site 436717008823 catalytic Zn binding site [ion binding]; other site 436717008824 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 436717008825 Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320 436717008826 active site 436717008827 purine riboside binding site [chemical binding]; other site 436717008828 quinolinate synthetase; Provisional; Region: PRK09375 436717008829 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 436717008830 heterotetramer interface [polypeptide binding]; other site 436717008831 active site pocket [active] 436717008832 cleavage site 436717008833 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 436717008834 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 436717008835 DNA binding site [nucleotide binding] 436717008836 active site 436717008837 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 436717008838 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 436717008839 Copper resistance protein B precursor (CopB); Region: CopB; pfam05275 436717008840 copper-resistance protein, CopA family; Region: copper_res_A; TIGR01480 436717008841 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 436717008842 Multicopper oxidase; Region: Cu-oxidase; pfam00394 436717008843 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 436717008844 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 436717008845 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 436717008846 active site 436717008847 motif I; other site 436717008848 motif II; other site 436717008849 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 436717008850 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 436717008851 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 436717008852 substrate binding site [chemical binding]; other site 436717008853 hexamer interface [polypeptide binding]; other site 436717008854 metal binding site [ion binding]; metal-binding site 436717008855 Uncharacterized protein conserved in bacteria (DUF2218); Region: DUF2218; pfam09981 436717008856 S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821 436717008857 S-formylglutathione hydrolase; Region: PLN02442 436717008858 Peptidase C13 family; Region: Peptidase_C13; pfam01650 436717008859 Putative SAM-dependent methyltransferase; Region: SAM_MT; cl17517 436717008860 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 436717008861 Glycoprotease family; Region: Peptidase_M22; pfam00814 436717008862 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 436717008863 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 436717008864 trimer interface [polypeptide binding]; other site 436717008865 putative metal binding site [ion binding]; other site 436717008866 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 436717008867 putative active site [active] 436717008868 putative CoA binding site [chemical binding]; other site 436717008869 nudix motif; other site 436717008870 metal binding site [ion binding]; metal-binding site 436717008871 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 436717008872 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_4; cd04511 436717008873 nudix motif; other site 436717008874 Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; cl17479 436717008875 bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase precursor protein; Reviewed; Region: PRK11907 436717008876 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39G; cd02423 436717008877 putative active site [active] 436717008878 anthranilate synthase component I; Reviewed; Region: PRK06404 436717008879 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 436717008880 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 436717008881 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 436717008882 pyridoxal 5'-phosphate binding site [chemical binding]; other site 436717008883 homodimer interface [polypeptide binding]; other site 436717008884 catalytic residue [active] 436717008885 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 436717008886 histidinol dehydrogenase; Region: hisD; TIGR00069 436717008887 NAD binding site [chemical binding]; other site 436717008888 dimerization interface [polypeptide binding]; other site 436717008889 product binding site; other site 436717008890 substrate binding site [chemical binding]; other site 436717008891 zinc binding site [ion binding]; other site 436717008892 catalytic residues [active] 436717008893 ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040 436717008894 ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686 436717008895 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 436717008896 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 436717008897 hinge; other site 436717008898 active site 436717008899 BolA-like protein; Region: BolA; cl00386 436717008900 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 436717008901 30S subunit binding site; other site 436717008902 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 436717008903 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 436717008904 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 436717008905 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 436717008906 VacJ like lipoprotein; Region: VacJ; cl01073 436717008907 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 436717008908 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 436717008909 anti sigma factor interaction site; other site 436717008910 regulatory phosphorylation site [posttranslational modification]; other site 436717008911 Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases); Region: nit; cd07572 436717008912 nitrilase; Region: PLN02798 436717008913 putative active site [active] 436717008914 catalytic triad [active] 436717008915 dimer interface [polypeptide binding]; other site 436717008916 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 436717008917 MarR family; Region: MarR; pfam01047 436717008918 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 436717008919 type II secretion system protein E; Region: type_II_gspE; TIGR02533 436717008920 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 436717008921 Walker A motif; other site 436717008922 ATP binding site [chemical binding]; other site 436717008923 Walker B motif; other site 436717008924 Protein of unknown function (DUF432); Region: DUF432; cl01027 436717008925 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 436717008926 Mechanosensitive ion channel; Region: MS_channel; pfam00924 436717008927 Predicted membrane protein (DUF2339); Region: DUF2339; pfam10101 436717008928 DNA polymerase I; Provisional; Region: PRK05755 436717008929 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 436717008930 active site 436717008931 metal binding site 1 [ion binding]; metal-binding site 436717008932 putative 5' ssDNA interaction site; other site 436717008933 metal binding site 3; metal-binding site 436717008934 metal binding site 2 [ion binding]; metal-binding site 436717008935 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 436717008936 putative DNA binding site [nucleotide binding]; other site 436717008937 putative metal binding site [ion binding]; other site 436717008938 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 436717008939 active site 436717008940 catalytic site [active] 436717008941 substrate binding site [chemical binding]; other site 436717008942 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 436717008943 active site 436717008944 DNA binding site [nucleotide binding] 436717008945 catalytic site [active] 436717008946 YGGT family; Region: YGGT; pfam02325 436717008947 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 436717008948 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 436717008949 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 436717008950 TilS substrate binding domain; Region: TilS; pfam09179 436717008951 TilS substrate C-terminal domain; Region: TilS_C; pfam11734 436717008952 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 436717008953 guanosine pentaphosphate phosphohydrolase; Provisional; Region: PRK11031 436717008954 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 436717008955 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 436717008956 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 436717008957 catalytic residues [active] 436717008958 transcription termination factor Rho; Provisional; Region: rho; PRK09376 436717008959 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 436717008960 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 436717008961 RNA binding site [nucleotide binding]; other site 436717008962 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 436717008963 multimer interface [polypeptide binding]; other site 436717008964 Walker A motif; other site 436717008965 ATP binding site [chemical binding]; other site 436717008966 Walker B motif; other site 436717008967 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 436717008968 IHF dimer interface [polypeptide binding]; other site 436717008969 IHF - DNA interface [nucleotide binding]; other site 436717008970 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 436717008971 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 436717008972 putative tRNA-binding site [nucleotide binding]; other site 436717008973 B3/4 domain; Region: B3_4; pfam03483 436717008974 tRNA synthetase B5 domain; Region: B5; smart00874 436717008975 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 436717008976 dimer interface [polypeptide binding]; other site 436717008977 motif 1; other site 436717008978 motif 3; other site 436717008979 motif 2; other site 436717008980 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 436717008981 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 436717008982 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 436717008983 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 436717008984 dimer interface [polypeptide binding]; other site 436717008985 motif 1; other site 436717008986 active site 436717008987 motif 2; other site 436717008988 motif 3; other site 436717008989 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 436717008990 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 436717008991 Coenzyme A binding pocket [chemical binding]; other site 436717008992 Domain of unknown function (DUF1768); Region: DUF1768; pfam08719 436717008993 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 436717008994 23S rRNA binding site [nucleotide binding]; other site 436717008995 L21 binding site [polypeptide binding]; other site 436717008996 L13 binding site [polypeptide binding]; other site 436717008997 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 436717008998 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 436717008999 putative substrate translocation pore; other site 436717009000 H+ Antiporter protein; Region: 2A0121; TIGR00900 436717009001 Predicted membrane protein [Function unknown]; Region: COG1238 436717009002 GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972 436717009003 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 436717009004 C-terminal domain interface [polypeptide binding]; other site 436717009005 GSH binding site (G-site) [chemical binding]; other site 436717009006 dimer interface [polypeptide binding]; other site 436717009007 C-terminal, alpha helical domain of Escherichia coli YfcG Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YfcG_like; cd10291 436717009008 N-terminal domain interface [polypeptide binding]; other site 436717009009 putative dimer interface [polypeptide binding]; other site 436717009010 active site 436717009011 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 436717009012 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 436717009013 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 436717009014 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 436717009015 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 436717009016 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 436717009017 active site 436717009018 dimer interface [polypeptide binding]; other site 436717009019 motif 1; other site 436717009020 motif 2; other site 436717009021 motif 3; other site 436717009022 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 436717009023 anticodon binding site; other site 436717009024 acyl-CoA synthetase; Validated; Region: PRK08162 436717009025 Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles and Arabidopsis; Region: ttLC_FACS_AEE21_like; cd12118 436717009026 acyl-activating enzyme (AAE) consensus motif; other site 436717009027 putative active site [active] 436717009028 AMP binding site [chemical binding]; other site 436717009029 putative CoA binding site [chemical binding]; other site 436717009030 hypothetical protein; Provisional; Region: PRK05255 436717009031 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 436717009032 dimerization domain swap beta strand [polypeptide binding]; other site 436717009033 regulatory protein interface [polypeptide binding]; other site 436717009034 active site 436717009035 regulatory phosphorylation site [posttranslational modification]; other site 436717009036 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 436717009037 pantoate--beta-alanine ligase; Region: panC; TIGR00018 436717009038 Pantoate-beta-alanine ligase; Region: PanC; cd00560 436717009039 active site 436717009040 ATP-binding site [chemical binding]; other site 436717009041 pantoate-binding site; other site 436717009042 HXXH motif; other site 436717009043 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 436717009044 oligomerization interface [polypeptide binding]; other site 436717009045 active site 436717009046 metal binding site [ion binding]; metal-binding site 436717009047 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 436717009048 catalytic center binding site [active] 436717009049 ATP binding site [chemical binding]; other site 436717009050 poly(A) polymerase; Region: pcnB; TIGR01942 436717009051 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 436717009052 active site 436717009053 NTP binding site [chemical binding]; other site 436717009054 metal binding triad [ion binding]; metal-binding site 436717009055 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 436717009056 Polymerase A arginine-rich C-terminus; Region: PolyA_pol_arg_C; pfam12626 436717009057 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 436717009058 Helix-hairpin-helix motif; Region: HHH; pfam00633 436717009059 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 436717009060 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 436717009061 homodimer interface [polypeptide binding]; other site 436717009062 metal binding site [ion binding]; metal-binding site 436717009063 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 436717009064 homodimer interface [polypeptide binding]; other site 436717009065 active site 436717009066 putative chemical substrate binding site [chemical binding]; other site 436717009067 metal binding site [ion binding]; metal-binding site 436717009068 short chain dehydrogenase; Provisional; Region: PRK08267 436717009069 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 436717009070 NAD(P) binding site [chemical binding]; other site 436717009071 active site 436717009072 HD domain; Region: HD_4; pfam13328 436717009073 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 436717009074 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 436717009075 synthetase active site [active] 436717009076 NTP binding site [chemical binding]; other site 436717009077 metal binding site [ion binding]; metal-binding site 436717009078 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 436717009079 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 436717009080 23S rRNA m(5)U1939 methyltransferase; Reviewed; Region: rumA; PRK13168 436717009081 TRAM domain; Region: TRAM; pfam01938 436717009082 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 436717009083 S-adenosylmethionine binding site [chemical binding]; other site 436717009084 Uncharacterized bacterial subgroup of the DEDDy 3'-5' exonuclease domain of family-B DNA polymerases; Region: DNA_polB_like1_exo; cd05782 436717009085 active site 436717009086 catalytic site [active] 436717009087 substrate binding site [chemical binding]; other site 436717009088 Predicted 3'-5' exonuclease related to the exonuclease domain of PolB; Region: DNA_pol_B_exo2; pfam10108 436717009089 cysteine synthase B; Region: cysM; TIGR01138 436717009090 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 436717009091 dimer interface [polypeptide binding]; other site 436717009092 pyridoxal 5'-phosphate binding site [chemical binding]; other site 436717009093 catalytic residue [active] 436717009094 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 436717009095 dimer interface [polypeptide binding]; other site 436717009096 phosphorylation site [posttranslational modification] 436717009097 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 436717009098 ATP binding site [chemical binding]; other site 436717009099 Mg2+ binding site [ion binding]; other site 436717009100 G-X-G motif; other site 436717009101 Response regulator receiver domain; Region: Response_reg; pfam00072 436717009102 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 436717009103 active site 436717009104 phosphorylation site [posttranslational modification] 436717009105 intermolecular recognition site; other site 436717009106 dimerization interface [polypeptide binding]; other site 436717009107 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 436717009108 putative binding surface; other site 436717009109 active site 436717009110 enoyl-CoA hydratase; Provisional; Region: PRK07509 436717009111 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 436717009112 substrate binding site [chemical binding]; other site 436717009113 oxyanion hole (OAH) forming residues; other site 436717009114 trimer interface [polypeptide binding]; other site 436717009115 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 436717009116 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 436717009117 hydroxypyruvate isomerase; Region: OH-pyruv-isom; TIGR03234 436717009118 iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090 436717009119 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 436717009120 acetoacetyl-CoA reductase; Provisional; Region: PRK12935 436717009121 putative NAD(P) binding site [chemical binding]; other site 436717009122 active site 436717009123 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 436717009124 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; COG1282 436717009125 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 436717009126 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 436717009127 NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288 436717009128 ligand binding site [chemical binding]; other site 436717009129 homodimer interface [polypeptide binding]; other site 436717009130 NAD(P) binding site [chemical binding]; other site 436717009131 trimer interface B [polypeptide binding]; other site 436717009132 trimer interface A [polypeptide binding]; other site 436717009133 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 436717009134 EamA-like transporter family; Region: EamA; pfam00892 436717009135 EamA-like transporter family; Region: EamA; pfam00892 436717009136 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 436717009137 homotrimer interaction site [polypeptide binding]; other site 436717009138 putative active site [active] 436717009139 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 436717009140 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 436717009141 putative substrate translocation pore; other site 436717009142 tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815 436717009143 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 436717009144 FMN binding site [chemical binding]; other site 436717009145 active site 436717009146 catalytic residues [active] 436717009147 substrate binding site [chemical binding]; other site 436717009148 Transcriptional regulator [Transcription]; Region: LysR; COG0583 436717009149 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 436717009150 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 436717009151 dimerization interface [polypeptide binding]; other site 436717009152 substrate binding pocket [chemical binding]; other site 436717009153 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179 436717009154 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 436717009155 putative ATP binding site [chemical binding]; other site 436717009156 putative substrate interface [chemical binding]; other site 436717009157 aconitate hydratase; Validated; Region: PRK09277 436717009158 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 436717009159 substrate binding site [chemical binding]; other site 436717009160 ligand binding site [chemical binding]; other site 436717009161 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 436717009162 substrate binding site [chemical binding]; other site 436717009163 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 436717009164 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 436717009165 active site 436717009166 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 436717009167 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 436717009168 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 436717009169 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 436717009170 G1 box; other site 436717009171 putative GEF interaction site [polypeptide binding]; other site 436717009172 GTP/Mg2+ binding site [chemical binding]; other site 436717009173 Switch I region; other site 436717009174 G2 box; other site 436717009175 G3 box; other site 436717009176 Switch II region; other site 436717009177 G4 box; other site 436717009178 G5 box; other site 436717009179 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 436717009180 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 436717009181 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 436717009182 MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300 436717009183 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 436717009184 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 436717009185 metal binding site [ion binding]; metal-binding site 436717009186 active site 436717009187 I-site; other site 436717009188 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 436717009189 ketol-acid reductoisomerase; Provisional; Region: PRK05479 436717009190 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 436717009191 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 436717009192 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 436717009193 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 436717009194 putative valine binding site [chemical binding]; other site 436717009195 dimer interface [polypeptide binding]; other site 436717009196 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 436717009197 acetolactate synthase 3 catalytic subunit; Validated; Region: PRK06466 436717009198 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 436717009199 PYR/PP interface [polypeptide binding]; other site 436717009200 dimer interface [polypeptide binding]; other site 436717009201 TPP binding site [chemical binding]; other site 436717009202 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 436717009203 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 436717009204 TPP-binding site [chemical binding]; other site 436717009205 dimer interface [polypeptide binding]; other site 436717009206 Domain of unknown function (DUF4124); Region: DUF4124; pfam13511 436717009207 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 436717009208 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 436717009209 HIGH motif; other site 436717009210 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 436717009211 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 436717009212 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 436717009213 active site 436717009214 KMSKS motif; other site 436717009215 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 436717009216 tRNA binding surface [nucleotide binding]; other site 436717009217 Lipopolysaccharide-assembly; Region: LptE; pfam04390 436717009218 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 436717009219 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 436717009220 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 436717009221 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 436717009222 HlyD family secretion protein; Region: HlyD_3; pfam13437 436717009223 macrolide transporter ATP-binding /permease protein; Provisional; Region: PRK10535 436717009224 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 436717009225 Walker A/P-loop; other site 436717009226 ATP binding site [chemical binding]; other site 436717009227 Q-loop/lid; other site 436717009228 ABC transporter signature motif; other site 436717009229 Walker B; other site 436717009230 D-loop; other site 436717009231 H-loop/switch region; other site 436717009232 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 436717009233 FtsX-like permease family; Region: FtsX; pfam02687 436717009234 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 436717009235 Enoyl-[acyl-carrier-protein]; Region: FabI; COG0623 436717009236 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 436717009237 NAD binding site [chemical binding]; other site 436717009238 homotetramer interface [polypeptide binding]; other site 436717009239 homodimer interface [polypeptide binding]; other site 436717009240 substrate binding site [chemical binding]; other site 436717009241 active site 436717009242 Bax inhibitor 1 like; Region: BaxI_1; cl17691 436717009243 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 436717009244 catalytic site [active] 436717009245 putative active site [active] 436717009246 putative substrate binding site [chemical binding]; other site 436717009247 dimer interface [polypeptide binding]; other site 436717009248 GTPase RsgA; Reviewed; Region: PRK12288 436717009249 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 436717009250 RNA binding site [nucleotide binding]; other site 436717009251 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 436717009252 GTPase/Zn-binding domain interface [polypeptide binding]; other site 436717009253 GTP/Mg2+ binding site [chemical binding]; other site 436717009254 G4 box; other site 436717009255 G5 box; other site 436717009256 G1 box; other site 436717009257 Switch I region; other site 436717009258 G2 box; other site 436717009259 G3 box; other site 436717009260 Switch II region; other site 436717009261 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 436717009262 active site residue [active] 436717009263 Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418 436717009264 GSH binding site [chemical binding]; other site 436717009265 catalytic residues [active] 436717009266 preprotein translocase subunit SecB; Validated; Region: PRK05751 436717009267 SecA binding site; other site 436717009268 Preprotein binding site; other site 436717009269 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 436717009270 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 436717009271 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK09116 436717009272 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 436717009273 dimer interface [polypeptide binding]; other site 436717009274 active site 436717009275 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 436717009276 3-oxoacyl-(acyl-carrier-protein) reductase, putative; Region: fabG_rel; TIGR01831 436717009277 NAD(P) binding site [chemical binding]; other site 436717009278 homotetramer interface [polypeptide binding]; other site 436717009279 homodimer interface [polypeptide binding]; other site 436717009280 active site 436717009281 Domain of unknown function, appears to be related to a diverse group of beta-hydroxydecanoyl ACP dehydratases (FabA) and beta-hydroxyacyl ACP dehydratases (FabZ). This group appears to lack the conserved active site histidine of FabA and FabZ; Region: FabA_like; cd01289 436717009282 putative active site 1 [active] 436717009283 3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK09185 436717009284 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 436717009285 dimer interface [polypeptide binding]; other site 436717009286 active site 436717009287 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 436717009288 Predicted exporter [General function prediction only]; Region: COG4258 436717009289 Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl17548 436717009290 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 436717009291 active site 436717009292 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 436717009293 active sites [active] 436717009294 tetramer interface [polypeptide binding]; other site 436717009295 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 436717009296 putative acyl-acceptor binding pocket; other site 436717009297 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 436717009298 Ligand binding site; other site 436717009299 Putative Catalytic site; other site 436717009300 DXD motif; other site 436717009301 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 436717009302 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 436717009303 acyl-activating enzyme (AAE) consensus motif; other site 436717009304 active site 436717009305 AMP binding site [chemical binding]; other site 436717009306 CoA binding site [chemical binding]; other site 436717009307 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 436717009308 active site 2 [active] 436717009309 active site 1 [active] 436717009310 Predicted membrane protein [Function unknown]; Region: COG4648 436717009311 acyl carrier protein; Provisional; Region: PRK05350 436717009312 Phosphopantetheine attachment site; Region: PP-binding; cl09936 436717009313 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 436717009314 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 436717009315 putative acyl-acceptor binding pocket; other site 436717009316 Beta-ketoacyl synthase, N-terminal domain; Region: Ketoacyl-synt_2; pfam13723 436717009317 GTP-binding protein Der; Reviewed; Region: PRK00093 436717009318 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 436717009319 G1 box; other site 436717009320 GTP/Mg2+ binding site [chemical binding]; other site 436717009321 Switch I region; other site 436717009322 G2 box; other site 436717009323 Switch II region; other site 436717009324 G3 box; other site 436717009325 G4 box; other site 436717009326 G5 box; other site 436717009327 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 436717009328 G1 box; other site 436717009329 GTP/Mg2+ binding site [chemical binding]; other site 436717009330 Switch I region; other site 436717009331 G2 box; other site 436717009332 G3 box; other site 436717009333 Switch II region; other site 436717009334 G4 box; other site 436717009335 G5 box; other site 436717009336 outer membrane assembly lipoprotein YfgL; Region: assembly_YfgL; TIGR03300 436717009337 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 436717009338 Trp docking motif [polypeptide binding]; other site 436717009339 active site 436717009340 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2976 436717009341 Uncharacterized protein conserved in bacteria (DUF2133); Region: DUF2133; pfam09976 436717009342 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 436717009343 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 436717009344 dimer interface [polypeptide binding]; other site 436717009345 motif 1; other site 436717009346 active site 436717009347 motif 2; other site 436717009348 motif 3; other site 436717009349 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 436717009350 anticodon binding site; other site 436717009351 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 436717009352 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 436717009353 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 436717009354 Helix-turn-helix domain; Region: HTH_25; pfam13413 436717009355 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 436717009356 type IV pilus biogenesis/stability protein PilW; Region: type_IV_pilW; TIGR02521 436717009357 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 436717009358 binding surface 436717009359 TPR motif; other site 436717009360 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 436717009361 TPR motif; other site 436717009362 binding surface 436717009363 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 436717009364 binding surface 436717009365 TPR motif; other site 436717009366 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK11194 436717009367 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 436717009368 FeS/SAM binding site; other site 436717009369 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 436717009370 active site 436717009371 multimer interface [polypeptide binding]; other site 436717009372 Iron-sulphur cluster assembly; Region: Fe-S_assembly; pfam04384 436717009373 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 436717009374 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 436717009375 active site 436717009376 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 436717009377 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 436717009378 carboxy-terminal protease; Provisional; Region: PRK11186 436717009379 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 436717009380 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 436717009381 protein binding site [polypeptide binding]; other site 436717009382 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 436717009383 Catalytic dyad [active] 436717009384 C-terminal domain of tail specific protease (DUF3340); Region: DUF3340; pfam11818 436717009385 beta-hexosaminidase; Provisional; Region: PRK05337 436717009386 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 436717009387 Leucine carboxyl methyltransferase; Region: LCM; pfam04072 436717009388 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 436717009389 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 436717009390 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 436717009391 putative catalytic cysteine [active] 436717009392 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 436717009393 ATP-binding site [chemical binding]; other site 436717009394 Gluconate-6-phosphate binding site [chemical binding]; other site 436717009395 Shikimate kinase; Region: SKI; pfam01202 436717009396 GntP family permease; Region: GntP_permease; pfam02447 436717009397 fructuronate transporter; Provisional; Region: PRK10034; cl15264 436717009398 keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718 436717009399 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 436717009400 active site 436717009401 intersubunit interface [polypeptide binding]; other site 436717009402 catalytic residue [active] 436717009403 phosphogluconate dehydratase; Validated; Region: PRK09054 436717009404 6-phosphogluconate dehydratase; Region: edd; TIGR01196 436717009405 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 436717009406 propionate/acetate kinase; Provisional; Region: PRK12379 436717009407 phosphate acetyltransferase; Reviewed; Region: PRK05632 436717009408 DRTGG domain; Region: DRTGG; pfam07085 436717009409 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 436717009410 Fumarate hydratase (Fumerase); Region: Fumerase; pfam05681 436717009411 Fumarase C-terminus; Region: Fumerase_C; pfam05683 436717009412 Uncharacterized protein conserved in bacteria (DUF2059); Region: DUF2059; pfam09832 436717009413 Protein of unknown function (DUF2846); Region: DUF2846; pfam11008 436717009414 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 436717009415 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 436717009416 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 436717009417 Walker A motif; other site 436717009418 ATP binding site [chemical binding]; other site 436717009419 Walker B motif; other site 436717009420 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 436717009421 Clp protease; Region: CLP_protease; pfam00574 436717009422 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 436717009423 oligomer interface [polypeptide binding]; other site 436717009424 active site residues [active] 436717009425 trigger factor; Provisional; Region: tig; PRK01490 436717009426 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 436717009427 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 436717009428 Outer membrane receptor for monomeric catechols [Inorganic ion transport and metabolism]; Region: Fiu; COG4774 436717009429 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 436717009430 N-terminal plug; other site 436717009431 ligand-binding site [chemical binding]; other site 436717009432 Fe(II)-dependent oxygenase superfamily protein; Provisional; Region: PRK05467 436717009433 2-isopropylmalate synthase; Validated; Region: PRK03739 436717009434 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 436717009435 active site 436717009436 catalytic residues [active] 436717009437 metal binding site [ion binding]; metal-binding site 436717009438 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 436717009439 homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175 436717009440 homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392 436717009441 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 436717009442 S-adenosylmethionine binding site [chemical binding]; other site 436717009443 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 436717009444 Sel1-like repeats; Region: SEL1; smart00671 436717009445 Sel1-like repeats; Region: SEL1; smart00671 436717009446 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 436717009447 active site 436717009448 dimerization interface [polypeptide binding]; other site 436717009449 potential frameshift: common BLAST hit: gi|169634435|ref|YP_001708171.1| putative permease 436717009450 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 436717009451 sec-independent translocase; Provisional; Region: tatB; PRK00404 436717009452 twin arginine-targeting protein translocase TatB; Region: tatB; TIGR01410 436717009453 Sec-independent protein translocase protein (TatC); Region: TatC; cl00521 436717009454 Bacterial protein of unknown function (DUF839); Region: DUF839; pfam05787 436717009455 Predicted phosphatase [General function prediction only]; Region: PhoX; COG3211 436717009456 NRDE protein; Region: NRDE; cl01315 436717009457 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK12437 436717009458 thymidylate synthase; Reviewed; Region: thyA; PRK01827 436717009459 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 436717009460 dimerization interface [polypeptide binding]; other site 436717009461 active site 436717009462 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 436717009463 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 436717009464 folate binding site [chemical binding]; other site 436717009465 NADP+ binding site [chemical binding]; other site 436717009466 Domain of unknown function (DUF4105); Region: DUF4105; pfam13387 436717009467 methionine sulfoxide reductase A; Provisional; Region: PRK14054 436717009468 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 436717009469 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 436717009470 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 436717009471 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 436717009472 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 436717009473 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 436717009474 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 436717009475 putative active site [active] 436717009476 putative substrate binding site [chemical binding]; other site 436717009477 putative cosubstrate binding site; other site 436717009478 catalytic site [active] 436717009479 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 436717009480 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 436717009481 Bacterial transcriptional repressor; Region: TetR; pfam13972 436717009482 Coniferyl aldehyde dehydrogenase-like; Region: ALDH_CALDH_CalB; cd07133 436717009483 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 436717009484 NAD(P) binding site [chemical binding]; other site 436717009485 catalytic residues [active] 436717009486 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 436717009487 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 436717009488 putative cation:proton antiport protein; Provisional; Region: PRK10669 436717009489 Kef-type K+ transport system, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: RosB; COG4651 436717009490 TrkA-N domain; Region: TrkA_N; pfam02254 436717009491 ASCH domain; Region: ASCH; pfam04266 436717009492 RNA-binding proteins (RRM domain) [General function prediction only]; Region: COG0724 436717009493 RNA recognition motif; Region: RRM; smart00360 436717009494 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 436717009495 Part of AAA domain; Region: AAA_19; pfam13245 436717009496 Family description; Region: UvrD_C_2; pfam13538 436717009497 Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247 436717009498 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 436717009499 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 436717009500 active site 436717009501 interdomain interaction site; other site 436717009502 putative metal-binding site [ion binding]; other site 436717009503 nucleotide binding site [chemical binding]; other site 436717009504 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 436717009505 domain I; other site 436717009506 DNA binding groove [nucleotide binding] 436717009507 phosphate binding site [ion binding]; other site 436717009508 domain II; other site 436717009509 domain III; other site 436717009510 nucleotide binding site [chemical binding]; other site 436717009511 catalytic site [active] 436717009512 domain IV; other site 436717009513 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 436717009514 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 436717009515 Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272 436717009516 Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272 436717009517 Predicted transcriptional regulators [Transcription]; Region: COG1733 436717009518 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 436717009519 Arginate lyase and other MDR family members; Region: AL_MDR; cd08252 436717009520 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817 436717009521 putative NAD(P) binding site [chemical binding]; other site 436717009522 dimer interface [polypeptide binding]; other site 436717009523 SlyX; Region: SlyX; pfam04102 436717009524 ABC transporter ATPase component; Reviewed; Region: PRK11147 436717009525 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 436717009526 Walker A/P-loop; other site 436717009527 ATP binding site [chemical binding]; other site 436717009528 ABC transporter signature motif; other site 436717009529 Walker B; other site 436717009530 D-loop; other site 436717009531 H-loop/switch region; other site 436717009532 ABC transporter; Region: ABC_tran_2; pfam12848 436717009533 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 436717009534 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 436717009535 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 436717009536 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 436717009537 putative acyl-acceptor binding pocket; other site 436717009538 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 436717009539 This family is most closely related to the GT1 family of glycosyltransferases. WavL in Vibrio cholerae has been shown to be involved in the biosynthesis of the lipopolysaccharide core; Region: GT1_WavL_like; cd03819 436717009540 putative ADP-binding pocket [chemical binding]; other site 436717009541 glutamate/aspartate:proton symporter; Provisional; Region: gltP; PRK11283 436717009542 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 436717009543 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 436717009544 putative catalytic site [active] 436717009545 putative metal binding site [ion binding]; other site 436717009546 putative phosphate binding site [ion binding]; other site 436717009547 aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK06598 436717009548 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 436717009549 FimV N-terminal domain; Region: FimV_core; TIGR03505 436717009550 Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963 436717009551 active site 436717009552 homodimer interface [polypeptide binding]; other site 436717009553 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 436717009554 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 436717009555 dimerization interface 3.5A [polypeptide binding]; other site 436717009556 active site 436717009557 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 436717009558 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 436717009559 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 436717009560 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 436717009561 rRNA binding site [nucleotide binding]; other site 436717009562 predicted 30S ribosome binding site; other site 436717009563 Protein of unknown function (DUF1311); Region: DUF1311; cl01530 436717009564 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 436717009565 tartrate dehydrogenase; Region: TTC; TIGR02089 436717009566 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 436717009567 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 436717009568 substrate binding site [chemical binding]; other site 436717009569 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 436717009570 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 436717009571 substrate binding site [chemical binding]; other site 436717009572 ligand binding site [chemical binding]; other site 436717009573 Predicted membrane protein (DUF2061); Region: DUF2061; pfam09834 436717009574 Transcriptional regulator [Transcription]; Region: LysR; COG0583 436717009575 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 436717009576 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 436717009577 dimerization interface [polypeptide binding]; other site 436717009578 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 436717009579 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 436717009580 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671 436717009581 putative active site [active] 436717009582 Ap4A binding site [chemical binding]; other site 436717009583 nudix motif; other site 436717009584 putative metal binding site [ion binding]; other site 436717009585 Signal transduction protein containing GAF and PtsI domains [Signal transduction mechanisms]; Region: PtsP; COG3605 436717009586 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 436717009587 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 436717009588 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 436717009589 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 436717009590 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 436717009591 Heme-dependent peroxidases similar to plant peroxidases; Region: plant_peroxidase_like; cl00196 436717009592 heme binding site [chemical binding]; other site 436717009593 Heme-dependent peroxidases similar to plant peroxidases; Region: plant_peroxidase_like; cl00196 436717009594 heme binding site [chemical binding]; other site 436717009595 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 436717009596 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 436717009597 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 436717009598 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 436717009599 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 436717009600 dimerization interface [polypeptide binding]; other site 436717009601 Protein of unknown function (DUF1345); Region: DUF1345; pfam07077 436717009602 GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972 436717009603 GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046 436717009604 putative C-terminal domain interface [polypeptide binding]; other site 436717009605 putative GSH binding site (G-site) [chemical binding]; other site 436717009606 putative dimer interface [polypeptide binding]; other site 436717009607 C-terminal, alpha helical domain of an unknown subfamily 8 of Glutathione S-transferases; Region: GST_C_8; cd03207 436717009608 dimer interface [polypeptide binding]; other site 436717009609 N-terminal domain interface [polypeptide binding]; other site 436717009610 putative substrate binding pocket (H-site) [chemical binding]; other site 436717009611 Predicted transcriptional regulator [Transcription]; Region: COG2378 436717009612 HTH domain; Region: HTH_11; pfam08279 436717009613 WYL domain; Region: WYL; pfam13280 436717009614 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 436717009615 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 436717009616 motif II; other site 436717009617 23S rRNA pseudouridylate synthase C; Provisional; Region: PRK11025 436717009618 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 436717009619 RNA binding surface [nucleotide binding]; other site 436717009620 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 436717009621 active site 436717009622 Ribonucleases G and E [Translation, ribosomal structure and biogenesis]; Region: CafA; COG1530 436717009623 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 436717009624 homodimer interface [polypeptide binding]; other site 436717009625 oligonucleotide binding site [chemical binding]; other site 436717009626 long-chain-acyl-CoA synthetase; Validated; Region: PRK08279 436717009627 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 436717009628 Fatty acid transport proteins (FATP) play dual roles as fatty acid transporters and its activation enzymes; Region: FATP_FACS; cd05940 436717009629 acyl-activating enzyme (AAE) consensus motif; other site 436717009630 putative AMP binding site [chemical binding]; other site 436717009631 putative active site [active] 436717009632 putative CoA binding site [chemical binding]; other site 436717009633 Transcriptional regulator [Transcription]; Region: LysR; COG0583 436717009634 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 436717009635 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 436717009636 putative effector binding pocket; other site 436717009637 putative dimerization interface [polypeptide binding]; other site 436717009638 short chain dehydrogenase; Provisional; Region: PRK12744 436717009639 tetrahydroxynaphthalene/trihydroxynaphthalene reductase-like, classical (c) SDRs; Region: THN_reductase-like_SDR_c; cd05362 436717009640 NADP binding site [chemical binding]; other site 436717009641 homodimer interface [polypeptide binding]; other site 436717009642 active site 436717009643 substrate binding site [chemical binding]; other site 436717009644 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 436717009645 HemN family oxidoreductase; Provisional; Region: PRK05660 436717009646 FeS/SAM binding site; other site 436717009647 HemN C-terminal domain; Region: HemN_C; pfam06969 436717009648 Protein of unknown function, DUF606; Region: DUF606; pfam04657 436717009649 multidrug efflux protein; Reviewed; Region: PRK01766 436717009650 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 436717009651 cation binding site [ion binding]; other site 436717009652 Dibenzothiophene (DBT) desulfurization enzyme C; Region: DszC; cd01163 436717009653 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 436717009654 Flavin binding site [chemical binding]; other site 436717009655 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 436717009656 Dibenzothiophene (DBT) desulfurization enzyme C; Region: DszC; cd01163 436717009657 Flavin binding site [chemical binding]; other site 436717009658 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 436717009659 ABC1 family; Region: ABC1; cl17513 436717009660 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 436717009661 HopJ type III effector protein; Region: HopJ; pfam08888 436717009662 chromosome condensation membrane protein; Provisional; Region: PRK14196 436717009663 Glutathione-dependent formaldehyde-activating enzyme; Region: GFA; pfam04828 436717009664 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 436717009665 uncharacterized flavoprotein, PP_4765 family; Region: flavo_PP4765; TIGR03862 436717009666 Putative methyltransferase; Region: Methyltransf_4; cl17290 436717009667 Domain of unknown function (DUF329); Region: DUF329; pfam03884 436717009668 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 436717009669 ferrochelatase; Reviewed; Region: hemH; PRK00035 436717009670 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 436717009671 C-terminal domain interface [polypeptide binding]; other site 436717009672 active site 436717009673 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 436717009674 active site 436717009675 N-terminal domain interface [polypeptide binding]; other site 436717009676 Domain of unknown function (DUF4062); Region: DUF4062; pfam13271 436717009677 glutamate racemase; Provisional; Region: PRK00865 436717009678 aspartate racemase; Region: asp_race; TIGR00035 436717009679 Protein of unknown function (DUF1285); Region: DUF1285; pfam06938 436717009680 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 436717009681 hydroxyglutarate oxidase; Provisional; Region: PRK11728 436717009682 Electron transfer flavoprotein-ubiquinone oxidoreductase; Region: ETF_QO; pfam05187 436717009683 Ferredoxin-like protein [Energy production and conversion]; Region: FixX; COG2440 436717009684 SirA (also known as UvrY, and YhhP) belongs to a family of two-component response regulators that controls secondary metabolism and virulence. The other member of this two-component system is a sensor kinase called BarA which phosphorylates SirA. A...; Region: SirA; cd03423 436717009685 CPxP motif; other site 436717009686 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 436717009687 Transporter associated domain; Region: CorC_HlyC; smart01091 436717009688 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 436717009689 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 436717009690 putative active site [active] 436717009691 catalytic triad [active] 436717009692 putative dimer interface [polypeptide binding]; other site 436717009693 tRNA-binding-domain-containing CsaA-like proteins. CsaA is a molecular chaperone with export related activities. CsaA has a putative tRNA binding activity. The functional unit of CsaA is a homodimer and this domain acts as a dimerization domain; Region: tRNA_bind_CsaA; cd02798 436717009694 dimer interface [polypeptide binding]; other site 436717009695 putative tRNA-binding site [nucleotide binding]; other site 436717009696 Protein of unknown function (DUF2798); Region: DUF2798; pfam11391 436717009697 type II secretion system protein G; Region: typeII_sec_gspG; TIGR01710 436717009698 Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334 436717009699 type II secretion system protein F; Region: GspF; TIGR02120 436717009700 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 436717009701 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 436717009702 primosome assembly protein PriA; Validated; Region: PRK05580 436717009703 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 436717009704 ATP binding site [chemical binding]; other site 436717009705 putative Mg++ binding site [ion binding]; other site 436717009706 helicase superfamily c-terminal domain; Region: HELICc; smart00490 436717009707 ATP-binding site [chemical binding]; other site 436717009708 glutathione-regulated potassium-efflux system protein KefC; Provisional; Region: PRK03562 436717009709 transporter, monovalent cation:proton antiporter-2 (CPA2) family; Region: 2a37; TIGR00932 436717009710 TrkA-N domain; Region: TrkA_N; pfam02254 436717009711 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 436717009712 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 436717009713 dimerization interface [polypeptide binding]; other site 436717009714 domain crossover interface; other site 436717009715 redox-dependent activation switch; other site 436717009716 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 436717009717 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 436717009718 chaperone protein DnaJ; Region: DnaJ_bact; TIGR02349 436717009719 HSP70 interaction site [polypeptide binding]; other site 436717009720 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 436717009721 substrate binding site [polypeptide binding]; other site 436717009722 dimer interface [polypeptide binding]; other site 436717009723 MerR HTH family regulatory protein; Region: MerR_2; pfam13591 436717009724 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 436717009725 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 436717009726 Thermotoga maritima CorA-like family; Region: TmCorA-like; cd12822 436717009727 oligomer interface [polypeptide binding]; other site 436717009728 metal binding site [ion binding]; metal-binding site 436717009729 metal binding site [ion binding]; metal-binding site 436717009730 putative Cl binding site [ion binding]; other site 436717009731 aspartate ring; other site 436717009732 basic sphincter; other site 436717009733 hydrophobic gate; other site 436717009734 periplasmic entrance; other site 436717009735 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 436717009736 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 436717009737 RNase E interface [polypeptide binding]; other site 436717009738 trimer interface [polypeptide binding]; other site 436717009739 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 436717009740 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 436717009741 RNase E interface [polypeptide binding]; other site 436717009742 trimer interface [polypeptide binding]; other site 436717009743 active site 436717009744 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 436717009745 putative nucleic acid binding region [nucleotide binding]; other site 436717009746 G-X-X-G motif; other site 436717009747 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 436717009748 RNA binding site [nucleotide binding]; other site 436717009749 domain interface; other site 436717009750 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 436717009751 16S/18S rRNA binding site [nucleotide binding]; other site 436717009752 S13e-L30e interaction site [polypeptide binding]; other site 436717009753 25S rRNA binding site [nucleotide binding]; other site 436717009754 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 436717009755 Beta-lactamase; Region: Beta-lactamase; pfam00144 436717009756 AAA domain; Region: AAA_30; pfam13604 436717009757 Family description; Region: UvrD_C_2; pfam13538 436717009758 Part of AAA domain; Region: AAA_19; pfam13245 436717009759 ATP-dependent exoDNAse (exonuclease V) beta subunit (contains helicase and exonuclease domains) [DNA replication, recombination, and repair]; Region: RecB; COG1074 436717009760 Family description; Region: UvrD_C_2; pfam13538 436717009761 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 436717009762 exodeoxyribonuclease V, gamma subunit; Region: recC; TIGR01450 436717009763 exonuclease V subunit gamma; Provisional; Region: recC; PRK11069 436717009764 Uncharacterized protein/domain associated with GTPases [Function unknown]; Region: COG3597 436717009765 Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971 436717009766 polyphosphate:AMP phosphotransferase; Region: poly_P_AMP_trns; TIGR03708 436717009767 Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971 436717009768 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 436717009769 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 436717009770 S-adenosylmethionine binding site [chemical binding]; other site 436717009771 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4627 436717009772 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3165 436717009773 ABC1 family; Region: ABC1; cl17513 436717009774 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 436717009775 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 436717009776 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 436717009777 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 436717009778 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_2; cd07253 436717009779 dimer interface [polypeptide binding]; other site 436717009780 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 436717009781 metal binding site [ion binding]; metal-binding site 436717009782 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 436717009783 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 436717009784 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 436717009785 metal binding site [ion binding]; metal-binding site 436717009786 Family description; Region: UvrD_C_2; pfam13538 436717009787 AAA domain; Region: AAA_23; pfam13476 436717009788 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 436717009789 ABC transporter signature motif; other site 436717009790 Walker B; other site 436717009791 D-loop; other site 436717009792 H-loop/switch region; other site 436717009793 putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12648 436717009794 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 436717009795 Domain of unknown function (DUF4040); Region: DUF4040; pfam13244 436717009796 Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111 436717009797 putative monovalent cation/H+ antiporter subunit B; Reviewed; Region: PRK12573 436717009798 putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK09094 436717009799 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12666 436717009800 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 436717009801 putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK08965 436717009802 Multiple resistance and pH regulation protein F (MrpF / PhaF); Region: MrpF_PhaF; cl09154 436717009803 putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12674 436717009804 ribosome-binding factor A; Provisional; Region: PRK13816 436717009805 translation initiation factor IF-2; Region: IF-2; TIGR00487 436717009806 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 436717009807 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 436717009808 G1 box; other site 436717009809 putative GEF interaction site [polypeptide binding]; other site 436717009810 GTP/Mg2+ binding site [chemical binding]; other site 436717009811 Switch I region; other site 436717009812 G2 box; other site 436717009813 G3 box; other site 436717009814 Switch II region; other site 436717009815 G4 box; other site 436717009816 G5 box; other site 436717009817 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 436717009818 Translation-initiation factor 2; Region: IF-2; pfam11987 436717009819 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 436717009820 transcription elongation factor NusA; Validated; Region: nusA; PRK09202 436717009821 NusA N-terminal domain; Region: NusA_N; pfam08529 436717009822 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 436717009823 RNA binding site [nucleotide binding]; other site 436717009824 homodimer interface [polypeptide binding]; other site 436717009825 NusA-like KH domain; Region: KH_5; pfam13184 436717009826 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 436717009827 G-X-X-G motif; other site 436717009828 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 436717009829 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 436717009830 Sm and related proteins; Region: Sm_like; cl00259 436717009831 ribosome maturation protein RimP; Reviewed; Region: PRK00092 436717009832 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 436717009833 putative oligomer interface [polypeptide binding]; other site 436717009834 putative RNA binding site [nucleotide binding]; other site 436717009835 potential protein location (hypothetical protein AOLE_17765 [Acinetobacter sp. DR1]) that overlaps RNA (tRNA-L and tRNAM) 436717009836 preprotein translocase subunit SecG; Reviewed; Region: secG; PRK06870 436717009837 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 436717009838 triosephosphate isomerase; Provisional; Region: PRK14567 436717009839 substrate binding site [chemical binding]; other site 436717009840 dimer interface [polypeptide binding]; other site 436717009841 catalytic triad [active] 436717009842 type IV-A pilus assembly ATPase PilB; Region: type_IV_pilB; TIGR02538 436717009843 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 436717009844 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 436717009845 Walker A motif; other site 436717009846 ATP binding site [chemical binding]; other site 436717009847 Walker B motif; other site 436717009848 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 436717009849 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 436717009850 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 436717009851 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 436717009852 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 436717009853 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 436717009854 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 436717009855 dephospho-CoA kinase; Region: TIGR00152 436717009856 CoA-binding site [chemical binding]; other site 436717009857 ATP-binding [chemical binding]; other site 436717009858 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 436717009859 EamA-like transporter family; Region: EamA; pfam00892 436717009860 23S rRNA (guanosine-2'-O-)-methyltransferase; Provisional; Region: PRK11181 436717009861 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 436717009862 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 436717009863 Protein of unknown function (DUF1255); Region: DUF1255; pfam06865 436717009864 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 436717009865 binding surface 436717009866 Tetratricopeptide repeat; Region: TPR_16; pfam13432 436717009867 TPR motif; other site 436717009868 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 436717009869 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 436717009870 Walker A/P-loop; other site 436717009871 ATP binding site [chemical binding]; other site 436717009872 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 436717009873 ABC transporter signature motif; other site 436717009874 Walker B; other site 436717009875 D-loop; other site 436717009876 H-loop/switch region; other site 436717009877 Uncharacterized ACR, COG1678; Region: DUF179; pfam02622 436717009878 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 436717009879 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 436717009880 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 436717009881 HlyD family secretion protein; Region: HlyD_3; pfam13437 436717009882 Protein of unknown function (DUF1656); Region: DUF1656; pfam07869 436717009883 Fusaric acid resistance protein family; Region: FUSC; pfam04632 436717009884 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 436717009885 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 436717009886 Transcriptional regulator [Transcription]; Region: IclR; COG1414 436717009887 Bacterial transcriptional regulator; Region: IclR; pfam01614 436717009888 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_2; pfam13532 436717009889 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 436717009890 Helix-turn-helix domain; Region: HTH_18; pfam12833 436717009891 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 436717009892 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 436717009893 DNA binding site [nucleotide binding] 436717009894 active site 436717009895 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 436717009896 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 436717009897 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 436717009898 active site 436717009899 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II; cd00556 436717009900 active site 436717009901 dimer interface [polypeptide binding]; other site 436717009902 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 436717009903 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 436717009904 GIY-YIG motif/motif A; other site 436717009905 active site 436717009906 catalytic site [active] 436717009907 putative DNA binding site [nucleotide binding]; other site 436717009908 metal binding site [ion binding]; metal-binding site 436717009909 UvrB/uvrC motif; Region: UVR; pfam02151 436717009910 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 436717009911 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 436717009912 Aspartyl/asparaginyl beta-hydroxylase and related dioxygenases [Posttranslational modification, protein turnover, chaperones]; Region: COG3555 436717009913 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadB; PRK11730 436717009914 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 436717009915 substrate binding site [chemical binding]; other site 436717009916 oxyanion hole (OAH) forming residues; other site 436717009917 trimer interface [polypeptide binding]; other site 436717009918 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 436717009919 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 436717009920 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 436717009921 3-ketoacyl-CoA thiolase; Reviewed; Region: fadA; PRK08947 436717009922 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 436717009923 dimer interface [polypeptide binding]; other site 436717009924 active site 436717009925 Predicted esterase of the alpha/beta hydrolase fold [General function prediction only]; Region: COG3545 436717009926 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 436717009927 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 436717009928 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 436717009929 DNA binding residues [nucleotide binding] 436717009930 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 436717009931 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 436717009932 catalytic residues [active] 436717009933 heat shock protein 90; Provisional; Region: PRK05218 436717009934 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 436717009935 ATP binding site [chemical binding]; other site 436717009936 Mg2+ binding site [ion binding]; other site 436717009937 G-X-G motif; other site 436717009938 Protein of unknown function (DUF1311); Region: DUF1311; pfam07007 436717009939 Outer membrane protein W [Cell envelope biogenesis, outer membrane]; Region: OmpW; COG3047 436717009940 Predicted permease [General function prediction only]; Region: COG2056 436717009941 Na+-H+ antiporter family; Region: Na_H_antiport_2; pfam13726 436717009942 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 436717009943 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 436717009944 active site 2 [active] 436717009945 active site 1 [active] 436717009946 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 436717009947 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 436717009948 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 436717009949 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 436717009950 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 436717009951 RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998 436717009952 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 436717009953 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 436717009954 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 436717009955 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 436717009956 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 436717009957 DNA binding site [nucleotide binding] 436717009958 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 436717009959 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 436717009960 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 436717009961 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 436717009962 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 436717009963 RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562 436717009964 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 436717009965 RPB1 interaction site [polypeptide binding]; other site 436717009966 RPB11 interaction site [polypeptide binding]; other site 436717009967 RPB10 interaction site [polypeptide binding]; other site 436717009968 RPB3 interaction site [polypeptide binding]; other site 436717009969 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 436717009970 core dimer interface [polypeptide binding]; other site 436717009971 peripheral dimer interface [polypeptide binding]; other site 436717009972 L10 interface [polypeptide binding]; other site 436717009973 L11 interface [polypeptide binding]; other site 436717009974 putative EF-Tu interaction site [polypeptide binding]; other site 436717009975 putative EF-G interaction site [polypeptide binding]; other site 436717009976 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 436717009977 23S rRNA interface [nucleotide binding]; other site 436717009978 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 436717009979 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 436717009980 mRNA/rRNA interface [nucleotide binding]; other site 436717009981 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 436717009982 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 436717009983 23S rRNA interface [nucleotide binding]; other site 436717009984 L7/L12 interface [polypeptide binding]; other site 436717009985 putative thiostrepton binding site; other site 436717009986 L25 interface [polypeptide binding]; other site 436717009987 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 436717009988 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 436717009989 putative homodimer interface [polypeptide binding]; other site 436717009990 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 436717009991 heterodimer interface [polypeptide binding]; other site 436717009992 homodimer interface [polypeptide binding]; other site 436717009993 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK05740 436717009994 elongation factor Tu; Reviewed; Region: PRK00049 436717009995 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 436717009996 G1 box; other site 436717009997 GEF interaction site [polypeptide binding]; other site 436717009998 GTP/Mg2+ binding site [chemical binding]; other site 436717009999 Switch I region; other site 436717010000 G2 box; other site 436717010001 G3 box; other site 436717010002 Switch II region; other site 436717010003 G4 box; other site 436717010004 G5 box; other site 436717010005 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 436717010006 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 436717010007 Antibiotic Binding Site [chemical binding]; other site 436717010008 anthranilate synthase component I; Provisional; Region: PRK13565 436717010009 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 436717010010 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 436717010011 phosphoglycolate phosphatase; Provisional; Region: PRK13222 436717010012 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 436717010013 motif II; other site 436717010014 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 436717010015 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 436717010016 phosphopeptide binding site; other site 436717010017 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 436717010018 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 436717010019 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 436717010020 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 436717010021 type II secretion system protein C; Region: typeII_sec_gspC; TIGR01713 436717010022 Type IV pilus biogenesis; Region: Pilus_PilP; pfam11356 436717010023 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 436717010024 Type II secretion system (T2SS), protein N; Region: T2SN; pfam01203 436717010025 H-NS histone family; Region: Histone_HNS; pfam00816 436717010026 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 436717010027 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 436717010028 active site 436717010029 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 436717010030 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 436717010031 active site 436717010032 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 436717010033 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 436717010034 domain interfaces; other site 436717010035 active site 436717010036 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 436717010037 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 436717010038 active site 436717010039 phosphorylation site [posttranslational modification] 436717010040 intermolecular recognition site; other site 436717010041 dimerization interface [polypeptide binding]; other site 436717010042 LytTr DNA-binding domain; Region: LytTR; smart00850 436717010043 Histidine kinase; Region: His_kinase; pfam06580 436717010044 argininosuccinate lyase; Provisional; Region: PRK00855 436717010045 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 436717010046 active sites [active] 436717010047 tetramer interface [polypeptide binding]; other site 436717010048 oxidative damage protection protein; Provisional; Region: PRK05408 436717010049 transcriptional regulator PhoU; Provisional; Region: PRK11115 436717010050 PhoU domain; Region: PhoU; pfam01895 436717010051 PhoU domain; Region: PhoU; pfam01895 436717010052 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 436717010053 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 436717010054 EamA-like transporter family; Region: EamA; pfam00892 436717010055 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 436717010056 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 436717010057 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 436717010058 ThiC-associated domain; Region: ThiC-associated; pfam13667 436717010059 Thiamine biosynthesis protein ThiC [Coenzyme metabolism]; Region: ThiC; COG0422 436717010060 ADP-ribose pyrophosphatase NudF; Provisional; Region: nudF; PRK10729 436717010061 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 436717010062 dimer interface [polypeptide binding]; other site 436717010063 ADP-ribose binding site [chemical binding]; other site 436717010064 active site 436717010065 nudix motif; other site 436717010066 metal binding site [ion binding]; metal-binding site 436717010067 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 436717010068 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 436717010069 active site 436717010070 metal binding site [ion binding]; metal-binding site 436717010071 hexamer interface [polypeptide binding]; other site 436717010072 RNA polymerase-binding protein DksA; Region: dksA; TIGR02420 436717010073 glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710 436717010074 active site 436717010075 HIGH motif; other site 436717010076 nucleotide binding site [chemical binding]; other site 436717010077 cell division protein FtsW; Region: ftsW; TIGR02614 436717010078 potential frameshift: common BLAST hit: gi|184156588|ref|YP_001844927.1| UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase 436717010079 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 436717010080 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 436717010081 G1 box; other site 436717010082 GTP/Mg2+ binding site [chemical binding]; other site 436717010083 Switch I region; other site 436717010084 G2 box; other site 436717010085 G3 box; other site 436717010086 Switch II region; other site 436717010087 G4 box; other site 436717010088 G5 box; other site 436717010089 Nucleoside recognition; Region: Gate; pfam07670 436717010090 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 436717010091 Nucleoside recognition; Region: Gate; pfam07670 436717010092 FeoA domain; Region: FeoA; pfam04023 436717010093 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 436717010094 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 436717010095 active site 436717010096 Int/Topo IB signature motif; other site 436717010097 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 436717010098 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020 436717010099 dimerization domain [polypeptide binding]; other site 436717010100 dimer interface [polypeptide binding]; other site 436717010101 catalytic residues [active] 436717010102 homoserine dehydrogenase; Provisional; Region: PRK06349 436717010103 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 436717010104 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 436717010105 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 436717010106 threonine synthase; Reviewed; Region: PRK06721 436717010107 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 436717010108 homodimer interface [polypeptide binding]; other site 436717010109 pyridoxal 5'-phosphate binding site [chemical binding]; other site 436717010110 catalytic residue [active] 436717010111 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 436717010112 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 436717010113 response regulator; Provisional; Region: PRK09483 436717010114 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 436717010115 active site 436717010116 phosphorylation site [posttranslational modification] 436717010117 intermolecular recognition site; other site 436717010118 dimerization interface [polypeptide binding]; other site 436717010119 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 436717010120 DNA binding residues [nucleotide binding] 436717010121 dimerization interface [polypeptide binding]; other site 436717010122 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 436717010123 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 436717010124 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 436717010125 dimer interface [polypeptide binding]; other site 436717010126 phosphorylation site [posttranslational modification] 436717010127 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 436717010128 ATP binding site [chemical binding]; other site 436717010129 Mg2+ binding site [ion binding]; other site 436717010130 G-X-G motif; other site 436717010131 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 436717010132 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 436717010133 active site 436717010134 phosphorylation site [posttranslational modification] 436717010135 intermolecular recognition site; other site 436717010136 dimerization interface [polypeptide binding]; other site 436717010137 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 436717010138 Walker A motif; other site 436717010139 ATP binding site [chemical binding]; other site 436717010140 Walker B motif; other site 436717010141 arginine finger; other site 436717010142 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 436717010143 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 436717010144 C-terminal peptidase (prc); Region: prc; TIGR00225 436717010145 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cd00136 436717010146 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 436717010147 Catalytic dyad [active] 436717010148 phosphoglyceromutase; Provisional; Region: PRK05434 436717010149 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 436717010150 Predicted permeases [General function prediction only]; Region: COG0795; cl12074 436717010151 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 436717010152 Predicted permeases [General function prediction only]; Region: COG0795; cl12074 436717010153 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 436717010154 multifunctional aminopeptidase A; Provisional; Region: PRK00913 436717010155 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 436717010156 interface (dimer of trimers) [polypeptide binding]; other site 436717010157 Substrate-binding/catalytic site; other site 436717010158 Zn-binding sites [ion binding]; other site 436717010159 DNA polymerase III chi subunit, HolC; Region: DNA_pol3_chi; pfam04364 436717010160 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 436717010161 Lumazine binding domain; Region: Lum_binding; pfam00677 436717010162 Lumazine binding domain; Region: Lum_binding; pfam00677 436717010163 Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG3392 436717010164 D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; cl17344 436717010165 bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase; Provisional; Region: ribD; PRK10786 436717010166 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 436717010167 catalytic motif [active] 436717010168 Zn binding site [ion binding]; other site 436717010169 RibD C-terminal domain; Region: RibD_C; cl17279 436717010170 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 436717010171 ATP cone domain; Region: ATP-cone; pfam03477 436717010172 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 436717010173 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 436717010174 Nitrogen regulatory protein P-II; Region: P-II; smart00938 436717010175 Membrane fusogenic activity; Region: BMFP; pfam04380 436717010176 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 436717010177 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 436717010178 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 436717010179 Walker A motif; other site 436717010180 ATP binding site [chemical binding]; other site 436717010181 Walker B motif; other site 436717010182 arginine finger; other site 436717010183 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 436717010184 Predicted flavoprotein [General function prediction only]; Region: COG0431 436717010185 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 436717010186 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 436717010187 DNA-binding site [nucleotide binding]; DNA binding site 436717010188 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 436717010189 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 436717010190 pyridoxal 5'-phosphate binding site [chemical binding]; other site 436717010191 homodimer interface [polypeptide binding]; other site 436717010192 catalytic residue [active] 436717010193 class II aldolase/adducin domain protein; Provisional; Region: PRK07090 436717010194 intersubunit interface [polypeptide binding]; other site 436717010195 active site 436717010196 Zn2+ binding site [ion binding]; other site 436717010197 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 436717010198 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 436717010199 inhibitor site; inhibition site 436717010200 active site 436717010201 dimer interface [polypeptide binding]; other site 436717010202 catalytic residue [active] 436717010203 Bacterial protein of unknown function (Gcw_chp); Region: Gcw_chp; cl09901 436717010204 outer membrane porin, OprD family; Region: OprD; pfam03573 436717010205 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 436717010206 dimer interface [polypeptide binding]; other site 436717010207 substrate binding site [chemical binding]; other site 436717010208 metal binding sites [ion binding]; metal-binding site 436717010209 Predicted membrane protein [Function unknown]; Region: COG3686 436717010210 Long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07059 436717010211 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 436717010212 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 436717010213 acyl-activating enzyme (AAE) consensus motif; other site 436717010214 putative AMP binding site [chemical binding]; other site 436717010215 putative active site [active] 436717010216 putative CoA binding site [chemical binding]; other site 436717010217 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 436717010218 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 436717010219 CAP-like domain; other site 436717010220 active site 436717010221 primary dimer interface [polypeptide binding]; other site 436717010222 benzoate transport; Region: 2A0115; TIGR00895 436717010223 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 436717010224 putative substrate translocation pore; other site 436717010225 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 436717010226 Predicted membrane protein [Function unknown]; Region: COG2860 436717010227 UPF0126 domain; Region: UPF0126; pfam03458 436717010228 UPF0126 domain; Region: UPF0126; pfam03458 436717010229 hypothetical protein; Provisional; Region: PRK01752 436717010230 SEC-C motif; Region: SEC-C; pfam02810 436717010231 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 436717010232 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 436717010233 Transporter associated domain; Region: CorC_HlyC; smart01091 436717010234 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 436717010235 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 436717010236 putative transporter; Provisional; Region: PRK10504 436717010237 putative substrate translocation pore; other site 436717010238 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 436717010239 Uncharacterized bacterial muramidase containing a glycosyl hydrolase family 25 (GH25) catalytic domain. Endo-N-acetylmuramidases are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis...; Region: GH25_muramidase_1; cd06413 436717010240 active site 436717010241 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 436717010242 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 436717010243 active site 436717010244 DNA polymerase IV; Validated; Region: PRK02406 436717010245 DNA binding site [nucleotide binding] 436717010246 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150 436717010247 homotrimer interaction site [polypeptide binding]; other site 436717010248 putative active site [active] 436717010249 Protein of unknown function (DUF2726); Region: DUF2726; pfam10881 436717010250 hypothetical protein; Provisional; Region: PRK01254 436717010251 Radical SAM N-terminal; Region: Radical_SAM_N; pfam08497 436717010252 Radical SAM N-terminal; Region: Radical_SAM_N; pfam08497 436717010253 Domain of unknown function (DUF3362); Region: DUF3362; pfam11842 436717010254 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4222 436717010255 Cu(I)-responsive transcriptional regulator; Region: CueR; TIGR02044 436717010256 Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg6; cd04781 436717010257 DNA binding residues [nucleotide binding] 436717010258 putative dimer interface [polypeptide binding]; other site 436717010259 putative metal binding residues [ion binding]; other site 436717010260 Protein of unknown function (DUF2938); Region: DUF2938; pfam11158 436717010261 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 436717010262 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 436717010263 Protein of unknown function (DUF2798); Region: DUF2798; pfam11391 436717010264 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 436717010265 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 436717010266 N-acetyl-D-glucosamine binding site [chemical binding]; other site 436717010267 catalytic residue [active] 436717010268 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 436717010269 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 436717010270 dimer interface [polypeptide binding]; other site 436717010271 pyridoxal 5'-phosphate binding site [chemical binding]; other site 436717010272 catalytic residue [active] 436717010273 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 436717010274 Coenzyme A binding pocket [chemical binding]; other site 436717010275 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 436717010276 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 436717010277 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; pfam09995 436717010278 TonB-dependent copper receptor; Region: TonB-copper; TIGR01778 436717010279 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 436717010280 N-terminal plug; other site 436717010281 ligand-binding site [chemical binding]; other site 436717010282 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 436717010283 active site 436717010284 catalytic residues [active] 436717010285 metal binding site [ion binding]; metal-binding site 436717010286 Uncharacterized protein containing LysM domain [Function unknown]; Region: XkdP; COG1652 436717010287 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 436717010288 DNA protecting protein DprA; Region: dprA; TIGR00732 436717010289 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 436717010290 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 436717010291 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 436717010292 EamA-like transporter family; Region: EamA; pfam00892 436717010293 EamA-like transporter family; Region: EamA; pfam00892 436717010294 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 436717010295 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 436717010296 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 436717010297 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 436717010298 putative substrate translocation pore; other site 436717010299 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 436717010300 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 436717010301 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 436717010302 catalytic residues [active] 436717010303 dimer interface [polypeptide binding]; other site 436717010304 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 436717010305 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 436717010306 gamma subunit interface [polypeptide binding]; other site 436717010307 epsilon subunit interface [polypeptide binding]; other site 436717010308 LBP interface [polypeptide binding]; other site 436717010309 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 436717010310 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 436717010311 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 436717010312 alpha subunit interaction interface [polypeptide binding]; other site 436717010313 Walker A motif; other site 436717010314 ATP binding site [chemical binding]; other site 436717010315 Walker B motif; other site 436717010316 inhibitor binding site; inhibition site 436717010317 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 436717010318 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 436717010319 core domain interface [polypeptide binding]; other site 436717010320 delta subunit interface [polypeptide binding]; other site 436717010321 epsilon subunit interface [polypeptide binding]; other site 436717010322 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 436717010323 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 436717010324 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 436717010325 Walker A motif; other site 436717010326 ATP binding site [chemical binding]; other site 436717010327 Walker B motif; other site 436717010328 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 436717010329 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 436717010330 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 436717010331 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 436717010332 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 436717010333 F0F1 ATP synthase subunit C; Validated; Region: PRK06876 436717010334 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 436717010335 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 436717010336 ATP synthase I chain; Region: ATP_synt_I; cl09170 436717010337 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 436717010338 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 436717010339 intersubunit interface [polypeptide binding]; other site 436717010340 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 436717010341 metal binding site 2 [ion binding]; metal-binding site 436717010342 putative DNA binding helix; other site 436717010343 metal binding site 1 [ion binding]; metal-binding site 436717010344 dimer interface [polypeptide binding]; other site 436717010345 structural Zn2+ binding site [ion binding]; other site 436717010346 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 436717010347 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 436717010348 Walker A/P-loop; other site 436717010349 ATP binding site [chemical binding]; other site 436717010350 Q-loop/lid; other site 436717010351 ABC transporter signature motif; other site 436717010352 Walker B; other site 436717010353 D-loop; other site 436717010354 H-loop/switch region; other site 436717010355 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 436717010356 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 436717010357 ABC-ATPase subunit interface; other site 436717010358 dimer interface [polypeptide binding]; other site 436717010359 putative PBP binding regions; other site 436717010360 LysE type translocator; Region: LysE; cl00565 436717010361 Dyp-type peroxidase family; Region: Dyp_perox; cl01067 436717010362 malate dehydrogenase; Provisional; Region: PRK13529 436717010363 Malic enzyme, N-terminal domain; Region: malic; pfam00390 436717010364 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 436717010365 NAD(P) binding site [chemical binding]; other site 436717010366 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 436717010367 Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018 436717010368 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 436717010369 active site 436717010370 HIGH motif; other site 436717010371 nucleotide binding site [chemical binding]; other site 436717010372 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 436717010373 KMSK motif region; other site 436717010374 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 436717010375 tRNA binding surface [nucleotide binding]; other site 436717010376 anticodon binding site; other site 436717010377 Sporulation related domain; Region: SPOR; pfam05036 436717010378 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 436717010379 GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046 436717010380 putative C-terminal domain interface [polypeptide binding]; other site 436717010381 putative GSH binding site (G-site) [chemical binding]; other site 436717010382 putative dimer interface [polypeptide binding]; other site 436717010383 C-terminal, alpha helical domain of GTT1-like Glutathione S-transferases; Region: GST_C_GTT1_like; cd03189 436717010384 putative N-terminal domain interface [polypeptide binding]; other site 436717010385 putative dimer interface [polypeptide binding]; other site 436717010386 putative substrate binding pocket (H-site) [chemical binding]; other site 436717010387 OsmC-like protein; Region: OsmC; pfam02566 436717010388 Pirin; Region: Pirin; pfam02678 436717010389 Pirin-related protein [General function prediction only]; Region: COG1741 436717010390 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 436717010391 Domain of Unknown Function with PDB structure (DUF3861); Region: DUF3861; pfam12977 436717010392 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cl17326 436717010393 putative DNA binding helix; other site 436717010394 Predicted transcriptional regulators [Transcription]; Region: COG1695 436717010395 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 436717010396 GMP synthase; Reviewed; Region: guaA; PRK00074 436717010397 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 436717010398 AMP/PPi binding site [chemical binding]; other site 436717010399 candidate oxyanion hole; other site 436717010400 catalytic triad [active] 436717010401 potential glutamine specificity residues [chemical binding]; other site 436717010402 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 436717010403 ATP Binding subdomain [chemical binding]; other site 436717010404 Ligand Binding sites [chemical binding]; other site 436717010405 Dimerization subdomain; other site 436717010406 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399 436717010407 Predicted membrane protein [Function unknown]; Region: COG2259 436717010408 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 436717010409 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 436717010410 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 436717010411 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 436717010412 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 436717010413 P-loop; other site 436717010414 Magnesium ion binding site [ion binding]; other site 436717010415 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 436717010416 Magnesium ion binding site [ion binding]; other site 436717010417 Invasion gene expression up-regulator, SirB; Region: SirB; cl01184 436717010418 Stress-induced morphogen (activity unknown) [Signal transduction mechanisms]; Region: BolA; COG0271 436717010419 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 436717010420 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 436717010421 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 436717010422 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 436717010423 NAD(P) binding site [chemical binding]; other site 436717010424 active site 436717010425 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 436717010426 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 436717010427 catalytic site [active] 436717010428 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 436717010429 hydrophobic ligand binding site; other site 436717010430 Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033 436717010431 Protein of unknown function (DUF1329); Region: DUF1329; pfam07044 436717010432 Condensation domain; Region: Condensation; pfam00668 436717010433 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 436717010434 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 436717010435 The adenylation domain of nonribosomal peptide synthetases (NRPS), including salinosporamide A polyketide synthase; Region: A_NRPS_Ta1_like; cd12116 436717010436 acyl-activating enzyme (AAE) consensus motif; other site 436717010437 AMP binding site [chemical binding]; other site 436717010438 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 436717010439 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 436717010440 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 436717010441 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 436717010442 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 436717010443 active site 436717010444 acyl-CoA synthetase; Validated; Region: PRK05850 436717010445 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 436717010446 acyl-activating enzyme (AAE) consensus motif; other site 436717010447 active site 436717010448 DNA-binding transcriptional activator SdiA; Provisional; Region: PRK10188 436717010449 Autoinducer binding domain; Region: Autoind_bind; pfam03472 436717010450 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 436717010451 DNA binding residues [nucleotide binding] 436717010452 dimerization interface [polypeptide binding]; other site 436717010453 Autoinducer synthetase; Region: Autoind_synth; cl17404 436717010454 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 436717010455 metabolite-proton symporter; Region: 2A0106; TIGR00883 436717010456 putative substrate translocation pore; other site 436717010457 3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617 436717010458 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 436717010459 substrate binding site [chemical binding]; other site 436717010460 oxyanion hole (OAH) forming residues; other site 436717010461 trimer interface [polypeptide binding]; other site 436717010462 2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766 436717010463 enoyl-CoA hydratase; Provisional; Region: PRK05862 436717010464 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 436717010465 substrate binding site [chemical binding]; other site 436717010466 oxyanion hole (OAH) forming residues; other site 436717010467 trimer interface [polypeptide binding]; other site 436717010468 RNA recognition motif (RRM) superfamily; Region: RRM_SF; cl17169 436717010469 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 436717010470 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 436717010471 active site 436717010472 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 436717010473 Domain of unknown function (DUF3448); Region: DUF3448; pfam11930 436717010474 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 436717010475 acyl-activating enzyme (AAE) consensus motif; other site 436717010476 AMP binding site [chemical binding]; other site 436717010477 active site 436717010478 CoA binding site [chemical binding]; other site 436717010479 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 436717010480 3-hydroxyisobutyrate dehydrogenase; Region: HIBADH; TIGR01692 436717010481 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 436717010482 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 436717010483 tetrameric interface [polypeptide binding]; other site 436717010484 NAD binding site [chemical binding]; other site 436717010485 catalytic residues [active] 436717010486 Transcriptional regulator [Transcription]; Region: LysR; COG0583 436717010487 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 436717010488 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 436717010489 dimerization interface [polypeptide binding]; other site 436717010490 D-alanine/D-serine/glycine permease; Provisional; Region: PRK11049 436717010491 D-alanine/D-serine/glycine permease; Provisional; Region: PRK11049 436717010492 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150 436717010493 homotrimer interaction site [polypeptide binding]; other site 436717010494 putative active site [active] 436717010495 alanine racemase; Reviewed; Region: dadX; PRK03646 436717010496 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827 436717010497 active site 436717010498 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 436717010499 substrate binding site [chemical binding]; other site 436717010500 catalytic residues [active] 436717010501 dimer interface [polypeptide binding]; other site 436717010502 D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711 436717010503 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 436717010504 mRNA stabilisation; Region: mRNA_stabil; pfam13929 436717010505 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 436717010506 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 436717010507 putative DNA binding site [nucleotide binding]; other site 436717010508 putative Zn2+ binding site [ion binding]; other site 436717010509 AsnC family; Region: AsnC_trans_reg; pfam01037 436717010510 Predicted membrane protein [Function unknown]; Region: COG3503 436717010511 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 436717010512 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 436717010513 N-terminal plug; other site 436717010514 ligand-binding site [chemical binding]; other site 436717010515 SnoaL-like domain; Region: SnoaL_2; pfam12680 436717010516 Protein of unknown function (DUF1260); Region: DUF1260; pfam06877 436717010517 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 436717010518 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 436717010519 active site 436717010520 Predicted membrane protein [Function unknown]; Region: COG4420 436717010521 Protein of unknown function (DUF2867); Region: DUF2867; pfam11066 436717010522 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 436717010523 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 436717010524 putative substrate translocation pore; other site 436717010525 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 436717010526 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 436717010527 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 436717010528 NAD(P) binding site [chemical binding]; other site 436717010529 active site 436717010530 Uncharacterized protein conserved in bacteria [Function unknown]; Region: VgrG; COG3501 436717010531 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 436717010532 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 436717010533 Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296 436717010534 Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; pfam10106 436717010535 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 436717010536 Sel1-like repeats; Region: SEL1; smart00671 436717010537 Sel1-like repeats; Region: SEL1; smart00671 436717010538 Sel1-like repeats; Region: SEL1; smart00671 436717010539 Sel1-like repeats; Region: SEL1; smart00671 436717010540 Sel1-like repeats; Region: SEL1; smart00671 436717010541 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 436717010542 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 436717010543 Coenzyme A binding pocket [chemical binding]; other site 436717010544 Domain of unknown function (DUF4126); Region: DUF4126; pfam13548 436717010545 Protein of unknown function (DUF1451); Region: DUF1451; pfam07295 436717010546 2-methylisocitrate dehydratase, Fe/S-dependent; Region: 2met_isocit_dHY; TIGR02333 436717010547 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 436717010548 substrate binding site [chemical binding]; other site 436717010549 ligand binding site [chemical binding]; other site 436717010550 Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215 436717010551 substrate binding site [chemical binding]; other site 436717010552 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 436717010553 methylcitrate synthase; Provisional; Region: PRK12351 436717010554 oxalacetate binding site [chemical binding]; other site 436717010555 citrylCoA binding site [chemical binding]; other site 436717010556 coenzyme A binding site [chemical binding]; other site 436717010557 catalytic triad [active] 436717010558 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 436717010559 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 436717010560 tetramer interface [polypeptide binding]; other site 436717010561 active site 436717010562 Mg2+/Mn2+ binding site [ion binding]; other site 436717010563 Transcriptional regulators [Transcription]; Region: GntR; COG1802 436717010564 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 436717010565 DNA-binding site [nucleotide binding]; DNA binding site 436717010566 FCD domain; Region: FCD; pfam07729 436717010567 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 436717010568 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 436717010569 pyridoxal 5'-phosphate binding site [chemical binding]; other site 436717010570 homodimer interface [polypeptide binding]; other site 436717010571 catalytic residue [active] 436717010572 D-lactate dehydrogenase; Provisional; Region: PRK11183 436717010573 FAD binding domain; Region: FAD_binding_4; pfam01565 436717010574 D-lactate dehydrogenase, membrane binding; Region: Lact-deh-memb; pfam09330 436717010575 L-lactate dehydrogenase; Provisional; Region: lldD; PRK11197 436717010576 Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809 436717010577 active site 436717010578 substrate binding site [chemical binding]; other site 436717010579 FMN binding site [chemical binding]; other site 436717010580 putative catalytic residues [active] 436717010581 DNA-binding transcriptional repressor LldR; Provisional; Region: PRK10421 436717010582 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 436717010583 DNA-binding site [nucleotide binding]; DNA binding site 436717010584 FCD domain; Region: FCD; pfam07729 436717010585 L-lactate permease; Provisional; Region: PRK10420 436717010586 glycolate transporter; Provisional; Region: PRK09695 436717010587 phosphomannomutase CpsG; Provisional; Region: PRK15414 436717010588 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 436717010589 active site 436717010590 substrate binding site [chemical binding]; other site 436717010591 metal binding site [ion binding]; metal-binding site 436717010592 Sulfatase; Region: Sulfatase; pfam00884 436717010593 Acyltransferase family; Region: Acyl_transf_3; pfam01757 436717010594 Fucose 4-O-acetylase and related acetyltransferases [Carbohydrate transport and metabolism]; Region: NolL; COG3594 436717010595 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 436717010596 UDP-glucose 4-epimerase; Region: PLN02240 436717010597 NAD binding site [chemical binding]; other site 436717010598 homodimer interface [polypeptide binding]; other site 436717010599 active site 436717010600 substrate binding site [chemical binding]; other site 436717010601 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 436717010602 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 436717010603 active site 436717010604 dimer interface [polypeptide binding]; other site 436717010605 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 436717010606 dimer interface [polypeptide binding]; other site 436717010607 active site 436717010608 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 436717010609 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 436717010610 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 436717010611 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 436717010612 active site 436717010613 tetramer interface; other site 436717010614 Bacterial sugar transferase; Region: Bac_transf; pfam02397 436717010615 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 436717010616 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 436717010617 active site 436717010618 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 436717010619 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 436717010620 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 436717010621 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 436717010622 active site 436717010623 homodimer interface [polypeptide binding]; other site 436717010624 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 436717010625 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 436717010626 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 436717010627 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 436717010628 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 436717010629 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 436717010630 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 436717010631 trimer interface [polypeptide binding]; other site 436717010632 active site 436717010633 substrate binding site [chemical binding]; other site 436717010634 CoA binding site [chemical binding]; other site 436717010635 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 436717010636 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 436717010637 inhibitor-cofactor binding pocket; inhibition site 436717010638 pyridoxal 5'-phosphate binding site [chemical binding]; other site 436717010639 catalytic residue [active] 436717010640 putative trimer interface [polypeptide binding]; other site 436717010641 Bacterial transferase hexapeptide (six repeats); Region: Hexapep; pfam00132 436717010642 putative CoA binding site [chemical binding]; other site 436717010643 WcxM-like, Left-handed parallel beta-Helix (LbH) N-terminal domain: This group is composed of Xanthomonas campestris WcxM and proteins with similarity to the WcxM N-terminal domain. WcxM is thought to be bifunctional, catalyzing both the isomerization...; Region: LbH_WxcM_N_like; cd03358 436717010644 putative trimer interface [polypeptide binding]; other site 436717010645 putative active site [active] 436717010646 putative substrate binding site [chemical binding]; other site 436717010647 putative CoA binding site [chemical binding]; other site 436717010648 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 436717010649 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 436717010650 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 436717010651 Vi polysaccharide biosynthesis protein TviB; Provisional; Region: PRK15182 436717010652 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 436717010653 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 436717010654 Periplasmic protein involved in polysaccharide export, contains SLBB domain of b-grasp fold [Cell wall/membrane/envelope biogenesis]; Region: Wza; COG1596 436717010655 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 436717010656 Low molecular weight phosphatase family; Region: LMWPc; cd00115 436717010657 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 436717010658 active site 436717010659 tyrosine kinase; Provisional; Region: PRK11519 436717010660 Chain length determinant protein; Region: Wzz; pfam02706 436717010661 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 436717010662 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 436717010663 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 436717010664 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 436717010665 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 436717010666 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 436717010667 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 436717010668 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 436717010669 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 436717010670 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 436717010671 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 436717010672 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 436717010673 amidase catalytic site [active] 436717010674 Zn binding residues [ion binding]; other site 436717010675 substrate binding site [chemical binding]; other site 436717010676 quinolinate phosphoribosyltransferase; Validated; Region: PRK09016 436717010677 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 436717010678 dimerization interface [polypeptide binding]; other site 436717010679 active site 436717010680 phospholipase C, phosphocholine-specific, Pseudomonas-type; Region: PC_PLC; TIGR03396 436717010681 Phosphoesterase family; Region: Phosphoesterase; pfam04185 436717010682 Domain of unknown function (DUF756); Region: DUF756; pfam05506 436717010683 Domain of unknown function (DUF756); Region: DUF756; pfam05506 436717010684 ribonuclease PH; Reviewed; Region: rph; PRK00173 436717010685 Ribonuclease PH; Region: RNase_PH_bact; cd11362 436717010686 hexamer interface [polypeptide binding]; other site 436717010687 active site 436717010688 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 436717010689 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 436717010690 putative di-iron ligands [ion binding]; other site 436717010691 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_2; cd06216 436717010692 phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160 436717010693 FAD binding pocket [chemical binding]; other site 436717010694 FAD binding motif [chemical binding]; other site 436717010695 phosphate binding motif [ion binding]; other site 436717010696 beta-alpha-beta structure motif; other site 436717010697 NAD binding pocket [chemical binding]; other site 436717010698 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 436717010699 catalytic loop [active] 436717010700 iron binding site [ion binding]; other site 436717010701 DNA-binding transcriptional repressor FabR; Provisional; Region: PRK11202 436717010702 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 436717010703 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 436717010704 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 436717010705 DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019 436717010706 catalytic residues [active] 436717010707 hinge region; other site 436717010708 alpha helical domain; other site 436717010709 bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134 436717010710 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 436717010711 S-adenosylmethionine binding site [chemical binding]; other site 436717010712 phosphoglycolate phosphatase; Provisional; Region: PRK13222 436717010713 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 436717010714 active site 436717010715 motif I; other site 436717010716 motif II; other site 436717010717 putative oxoacyl-(acyl carrier protein) reductase; Provisional; Region: PRK08945 436717010718 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 436717010719 NAD(P) binding site [chemical binding]; other site 436717010720 active site 436717010721 Domain of unknown function (DUF3315); Region: DUF3315; pfam11776 436717010722 Domain of unknown function (DUF3315); Region: DUF3315; pfam11776 436717010723 N-acetylglutamate synthase; Validated; Region: PRK05279 436717010724 AAK_NAGS-ABP: N-acetylglutamate (NAG) kinase-like domain of the NAG Synthase (NAGS) of the arginine-biosynthesis pathway (ABP) found in gamma- and beta-proteobacteria and higher plant chloroplasts. Domain architecture of these NAGS consisted of an...; Region: AAK_NAGS-ABP; cd04237 436717010725 putative feedback inhibition sensing region; other site 436717010726 putative nucleotide binding site [chemical binding]; other site 436717010727 putative substrate binding site [chemical binding]; other site 436717010728 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 436717010729 Coenzyme A binding pocket [chemical binding]; other site 436717010730 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 436717010731 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 436717010732 substrate binding pocket [chemical binding]; other site 436717010733 membrane-bound complex binding site; other site 436717010734 hinge residues; other site 436717010735 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 436717010736 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 436717010737 substrate binding pocket [chemical binding]; other site 436717010738 membrane-bound complex binding site; other site 436717010739 hinge residues; other site 436717010740 alkanesulfonate monooxygenase; Provisional; Region: PRK00719 436717010741 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 436717010742 active site 436717010743 dimer interface [polypeptide binding]; other site 436717010744 non-prolyl cis peptide bond; other site 436717010745 insertion regions; other site 436717010746 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 436717010747 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 436717010748 putative PBP binding loops; other site 436717010749 dimer interface [polypeptide binding]; other site 436717010750 ABC-ATPase subunit interface; other site 436717010751 aliphatic sulfonates transport ATP-binding subunit; Provisional; Region: ssuB; PRK11247 436717010752 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 436717010753 Walker A/P-loop; other site 436717010754 ATP binding site [chemical binding]; other site 436717010755 Q-loop/lid; other site 436717010756 ABC transporter signature motif; other site 436717010757 Walker B; other site 436717010758 D-loop; other site 436717010759 H-loop/switch region; other site 436717010760 pyrimidine utilization regulatory protein R; Region: RutR; TIGR03613 436717010761 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 436717010762 YcdC-like protein, C-terminal region; Region: TetR_C_3; pfam08362 436717010763 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 436717010764 Tellurite resistance protein and related permeases [Inorganic ion transport and metabolism]; Region: TehA; COG1275 436717010765 Tellurite-resistance/Dicarboxylate Transporter (TDT) family includes sulfite sensitivity protein (sulfite efflux pump; SSU1); Region: TDT_SSU1; cd09318 436717010766 gating phenylalanine in ion channel; other site 436717010767 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 436717010768 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 436717010769 active site 436717010770 Riboflavin kinase; Region: Flavokinase; smart00904 436717010771 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 436717010772 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 436717010773 active site 436717010774 HIGH motif; other site 436717010775 nucleotide binding site [chemical binding]; other site 436717010776 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 436717010777 active site 436717010778 KMSKS motif; other site 436717010779 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 436717010780 tRNA binding surface [nucleotide binding]; other site 436717010781 anticodon binding site; other site 436717010782 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 436717010783 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 436717010784 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095 436717010785 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 436717010786 Predicted flavoprotein [General function prediction only]; Region: COG0431 436717010787 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 436717010788 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 436717010789 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 436717010790 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 436717010791 substrate binding site [chemical binding]; other site 436717010792 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 436717010793 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 436717010794 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 436717010795 Transcriptional regulator [Transcription]; Region: LysR; COG0583 436717010796 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 436717010797 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 436717010798 putative effector binding pocket; other site 436717010799 dimerization interface [polypeptide binding]; other site 436717010800 GrpE; Region: GrpE; pfam01025 436717010801 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 436717010802 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 436717010803 dimer interface [polypeptide binding]; other site 436717010804 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 436717010805 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 436717010806 nucleotide binding site [chemical binding]; other site 436717010807 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 436717010808 active site 436717010809 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 436717010810 active site 436717010811 Transglycosylase SLT domain; Region: SLT_2; pfam13406 436717010812 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 436717010813 N-acetyl-D-glucosamine binding site [chemical binding]; other site 436717010814 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 436717010815 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 436717010816 ATP-grasp domain; Region: ATP-grasp; pfam02222 436717010817 AIR carboxylase; Region: AIRC; pfam00731 436717010818 Protein of unknown function, DUF486; Region: DUF486; cl01236 436717010819 UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase; Region: mpl; TIGR01081 436717010820 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 436717010821 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 436717010822 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 436717010823 Bacterial low temperature requirement A protein (LtrA); Region: LtrA; cl01754 436717010824 PAP2_like proteins, BcrC_like subfamily. Several members of this family have been annotated as bacitracin transport permeases, as it was suspected that they form the permease component of an ABC transporter system. It was shown, however, that BcrC from...; Region: PAP2_BcrC_like; cd03385 436717010825 active site 436717010826 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 436717010827 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 436717010828 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 436717010829 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 436717010830 [2Fe-2S] cluster binding site [ion binding]; other site 436717010831 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 436717010832 hydrophobic ligand binding site; other site 436717010833 guanine deaminase; Provisional; Region: PRK09228 436717010834 Guanine deaminase (GDEase). Guanine deaminase is an aminohydrolase responsible for the conversion of guanine to xanthine and ammonia, the first step to utilize guanine as a nitrogen source. This reaction also removes the guanine base from the pool and...; Region: GDEase; cd01303 436717010835 active site 436717010836 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 436717010837 active site 436717010838 Predicted membrane protein [Function unknown]; Region: COG2261 436717010839 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 436717010840 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020 436717010841 dimerization domain [polypeptide binding]; other site 436717010842 dimer interface [polypeptide binding]; other site 436717010843 catalytic residues [active] 436717010844 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 436717010845 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 436717010846 Transcriptional regulators RcnR and FrmR, and related domains; this domain family was previously known as part of DUF156; Region: RcnR-FrmR-like_DUF156; cd10153 436717010847 putative metal binding site [ion binding]; other site 436717010848 putative homodimer interface [polypeptide binding]; other site 436717010849 putative homotetramer interface [polypeptide binding]; other site 436717010850 putative homodimer-homodimer interface [polypeptide binding]; other site 436717010851 putative allosteric switch controlling residues; other site 436717010852 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 436717010853 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 436717010854 trmE is a tRNA modification GTPase; Region: trmE; cd04164 436717010855 G1 box; other site 436717010856 GTP/Mg2+ binding site [chemical binding]; other site 436717010857 Switch I region; other site 436717010858 G2 box; other site 436717010859 Switch II region; other site 436717010860 G3 box; other site 436717010861 G4 box; other site 436717010862 G5 box; other site 436717010863 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 436717010864 membrane protein insertase; Provisional; Region: PRK01318 436717010865 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 436717010866 hypothetical protein; Provisional; Region: PRK14386 436717010867 Ribonuclease P; Region: Ribonuclease_P; cl00457 436717010868 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399